keyword
https://read.qxmd.com/read/38200556/characteristics-of-the-synovial-microenvironment-and-synovial-mesenchymal-stem-cells-with-hip-osteoarthritis-of-different-bone-morphologies
#1
JOURNAL ARTICLE
Yang Yang, Hideyuki Koga, Yusuke Nakagawa, Tomomasa Nakamura, Hiroki Katagiri, Ryohei Takada, Mai Katakura, Kunikazu Tsuji, Ichiro Sekiya, Kazumasa Miyatake
BACKGROUND: Variations in bone morphology in patients with hip osteoarthritis (HOA) can be broadly categorized into three types: atrophic, normotrophic, and hypertrophic. Despite the investigations examining clinical elements, such as bone morphology, pain, and range of motion, our understanding of the pathogenesis of HOA remains limited. Previous studies have suggested that osteophytes typically originate at the interface of the joint cartilage, periosteum, and synovium, potentially implicating synovial mesenchymal stem cells (SMSCs) in the process...
January 10, 2024: Arthritis Research & Therapy
https://read.qxmd.com/read/38010488/exploring-orthopedic-stem-cell-approaches-for-osteoarthritis-management-current-trends-and-future-horizons
#2
REVIEW
Mark Ehioghae, Tarun K Vippa, Dorothy Askins, Sonia Slusarczyk, Elena Bobo, Alexis Montoya, Danyon Anderson, Christopher L Robinson, Alan D Kaye, Ivan Urits
PURPOSE OF REVIEW: Osteoarthritis (OA) is a prevalent and debilitating condition characterized by joint degeneration and pain. Current treatment options aim to alleviate symptoms and slow disease progression but lack curative potential. Stem cell therapies have emerged as a promising alternative. This article explores the epidemiology, pathophysiology, clinical manifestations of hip and knee OA, and the evolving role of stem cell therapies in their treatment. RECENT FINDINGS: The global prevalence of OA, with knee OA being the most common form, has fueled the demand for stem cell therapies...
November 27, 2023: Current Pain and Headache Reports
https://read.qxmd.com/read/37815635/management-of-chondral-and-osteochondral-lesions-of-the-hip-a%C3%A2-comprehensive-review
#3
JOURNAL ARTICLE
Rajesh Itha, Raju Vaishya, Abhishek Vaish, Filippo Migliorini
Chondral and osteochondral lesions encompass several acute or chronic defects of the articular cartilage and/or subchondral bone. These lesions can result from several different diseases and injuries, including osteochondritis dissecans, osteochondral defects, osteochondral fractures, subchondral bone osteonecrosis, and insufficiency fractures. As the cartilage has a low capacity for regeneration and self-repair, these lesions can progress to osteoarthritis. This study provides a comprehensive overview of the subject matter that it covers...
October 10, 2023: Orthopadie (Heidelb)
https://read.qxmd.com/read/37731506/causal-relationships-between-cd25-on-immune-cells-and-hip-osteoarthritis
#4
JOURNAL ARTICLE
Hao Luo, Yong Zhu, Bin Guo, Zhe Ruan, Zhi Liu, Zhihua Fan, Shushan Zhao
OBJECTIVES: Previous research has indicated a potential association between immune factors and osteoarthritis (OA), but the causal relationship between CD25 expression on immune cells and hip OA remains enigmatic. To shed light on this relationship, this study utilized the two-sample Mendelian Randomization (MR) method. METHODS: Leveraging genome-wide association studies (GWAS) data from the UK Biobank and arcOGEN, the investigation encompasses a substantial European cohort comprising 15,704 hip OA cases and 378,169 controls...
2023: Frontiers in Immunology
https://read.qxmd.com/read/37551027/clinical-and-radiological-comparison-of-single-and-double-intra-articular-injection-of-adipose-derived-stromal-vascular-fraction-for-knee-osteoarthritis
#5
JOURNAL ARTICLE
Masahiro Fujita, Tomoyuki Matsumoto, Satoshi Sobajima, Masanori Tsubosaka, Takehiko Matsushita, Hideki Iwaguro, Ryosuke Kuroda
The aim of the article is to compare the clinical and radiological outcomes between single and double stromal vascular fraction (SVF) cell injections in patients with knee osteoarthritis (OA). We included 54 patients treated for varus knee OA with intra-articular SVF cell injection. They were divided into two groups: those who received one injection and those who received two. The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score, knee range of motion, and knee muscle force were assessed at baseline and 3, 6, 12, and 24 months after the first injection...
2023: Cell Transplantation
https://read.qxmd.com/read/37496424/current-evidence-on-mesenchymal-stem-cells-for-hip-osteoarthritis-a-narrative-review
#6
REVIEW
Mina Entessari, Leonardo P Oliveira
There are limited data on the use of mesenchymal stem cell injections for hip osteoarthritis. The goal of this study was to evaluate the literature by analyzing outcomes and comparing methodologies. Online search of PubMed, SportsDiscus and Case Reports Keywords was completed using the keywords 'stem cells' and 'hip' and 'osteoarthritis'. Six studies met the inclusion and exclusion criteria. Five out the six studies had statistically significant improvement in patient reported outcomes after mesenchymal stem cell injections...
September 2023: Regenerative Medicine
https://read.qxmd.com/read/37394226/recommendations-for-the-management-of-hip-and-knee-osteoarthritis-a-systematic-review-of-clinical-practice-guidelines
#7
REVIEW
Alison J Gibbs, Bimbi Gray, Jason A Wallis, Nicholas F Taylor, Joanne L Kemp, David J Hunter, Christian J Barton
OBJECTIVES: Guideline adherence for hip and knee osteoarthritis management is often poor, possibly related to the quality and/or inconsistent recommendations. This systematic review of hip and knee osteoarthritis guidelines aimed to appraise the quality and consistency in recommendations across higher-quality guidelines. METHODS: Eight databases, guideline repositories, and professional associations websites were searched on 27/10/2022. Guideline quality was appraised using the Appraisal of Guidelines for Research and Evaluation II (AGREE II tool) (six domains)...
October 2023: Osteoarthritis and Cartilage
https://read.qxmd.com/read/37363753/clinical-use-of-autologous-adipose-derived-stromal-vascular-fraction-cell-injections-for-hip-osteoarthritis
#8
JOURNAL ARTICLE
Yuma Onoi, Tomoyuki Matsumoto, Satoshi Sobajima, Masanori Tsubosaka, Shinya Hayashi, Takehiko Matsushita, Hideki Iwaguro, Ryosuke Kuroda
INTRODUCTION: Currently, studies on adipose-derived stromal vascular fraction (SVF) cells are attracting increasing attention because they have the potential to differentiate into a subset of cell types, such as bone marrow-derived mesenchymal stromal cells (MSCs), and are easier to harvest than MSCs, thus making them easier to apply clinically. This study evaluated the short-term clinical outcomes of SVF cell therapy for hip osteoarthritis (OA). METHODS: Forty-two patients were enrolled in this study; these patients received a single injection comprising an average of 3...
December 2023: Regenerative Therapy
https://read.qxmd.com/read/37047377/knee-osteoarthritis-epidemiology-pathogenesis-and-mesenchymal-stem-cells-what-else-is-new-an-update
#9
REVIEW
Riccardo Giorgino, Domenico Albano, Stefano Fusco, Giuseppe M Peretti, Laura Mangiavini, Carmelo Messina
Osteoarthritis (OA) is a chronic disease and the most common orthopedic disorder. A vast majority of the social OA burden is related to hips and knees. The prevalence of knee OA varied across studies and such differences are reflected by the heterogeneity of data reported by studies conducted worldwide. A complete understanding of the pathogenetic mechanisms underlying this pathology is essential. The OA inflammatory process starts in the synovial membrane with the activation of the immune system, involving both humoral and cellular mediators...
March 29, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/36453641/paired-bone-marrow-and-peripheral-blood-samples-demonstrate-lack-of-widespread-dissemination-of-some-ch-clones
#10
JOURNAL ARTICLE
Afaf Osman, Nuria Mencia-Trinchant, Caner Saygin, Luke Moma, Aelin Kim, Genevieve Housman, Matthew J Pozsgai, Eti Sinha, Pooja Chandra, Duane C Hassane, Andrea Sboner, Kishan Sangani, Nick DiNardi, Christopher Johnson, Sara S Wallace, Bana Jabri, Hue Luu, Monica L Guzman, Pinkal Desai, Lucy A Godley
Clonal hematopoiesis (CH) represents clonal expansion of mutated hematopoietic stem cells detectable in the peripheral blood or bone marrow through next generation sequencing. The current prevailing model posits that CH mutations detected in the peripheral blood mirror bone marrow mutations with clones widely disseminated across hematopoietic compartments. We sought to test the hypothesis that all clones are disseminated throughout hematopoietic tissues by comparing CH in hip versus peripheral blood specimens collected at the time of hip replacement surgery...
December 1, 2022: Blood Advances
https://read.qxmd.com/read/36452339/intra-articular-injection-of-mesenchymal-stem-cells-after-high-tibial-osteotomy-a-systematic-review-and-meta-analysis
#11
REVIEW
Lingpeng Jin, Guang Yang, Xiaoqian Men, Jian Zhang, Zhen Chen, Zhongwei Li, Yusheng Li, Jun Ma, Jiangtao Dong
BACKGROUND: Multiple studies have investigated the use of mesenchymal stem cells (MSCs) for patients undergoing high tibial osteotomy (HTO), and the effectiveness thereof remains controversial. PURPOSE: To analyze the effectiveness of intra-articular MSC injection in patients who underwent HTO in terms of clinical outcomes, radiological outcomes, and cartilage repair by a meta-analysis of the available literature. STUDY DESIGN: Systematic review; Level of evidence, 3...
November 2022: Orthopaedic Journal of Sports Medicine
https://read.qxmd.com/read/36314003/immunomodulatory-potential-of-secretome-from-cartilage-cells-and-mesenchymal-stromal-cells-in-an-arthritic-context-from-predictive-fiction-toward-reality
#12
JOURNAL ARTICLE
Alessandra Colombini, Francesca Libonati, Silvia Lopa, Enrico Ragni, Paola De Luca, Luigi Zagra, Federico Sinigaglia, Matteo Moretti, Laura de Girolamo
The purpose of the present study is to predict by bioinformatics the activity of the extracellular vesicle (EV)-embedded micro RNA (miRNAs) secreted by cartilage cells (CCs), adipose tissue-derived- (ASCs), and bone marrow-derived stem cells (BMSCs) and verify their immunomodulatory potential supporting our bioinformatics findings to optimize the autologous cell-based therapeutic strategies for osteoarthritis (OA) management. Cells were isolated from surgical waste tissues of three patients who underwent total hip replacement, expanded and the EVs were collected...
2022: Frontiers in Medicine
https://read.qxmd.com/read/36310763/mesenchymal-stem-cells-for-subchondral-bone-marrow-lesions-from-bench-to-bedside
#13
JOURNAL ARTICLE
Rosa M Pasculli, Charles D Kenyon, William A Berrigan, Kenneth Mautner, Kyle Hammond, Prathap Jayaram
Subchondral bone marrow lesions (BMLs) are areas of disease within subchondral bone that appear as T1 hypointense and T2 hyperintense ill-defined areas of bone marrow on magnetic resonance imaging. The most common bone marrow lesions include subchondral lesions related to osteoarthritis, osteochondral defects, and avascular necrosis. Emerging therapies include autologous biologic therapeutics, in particular mesenchymal stem cells (MSCs), to maintain and improve cartilage health; MSCs have become a potential treatment option for BMLs given the unmet need for disease modification...
December 2022: Bone Reports
https://read.qxmd.com/read/36302901/is-intra-articular-injection-of-autologous-micro-fragmented-adipose-tissue-effective-in-hip-osteoarthritis-a-three-year-follow-up
#14
JOURNAL ARTICLE
Simone Natali, Daniele Screpis, Michele Romeo, Stefano Magnanelli, Giuseppe Rovere, Amarossi Andrea, Lawrence Camarda, Claudio Zorzi
BACKGROUND: Recently, increased attention on regenerative medicine and biological injective treatments have been proposed to restore native cartilage. Micro-fragmented adipose tissue (MFAT) has been studied for its anti-inflammatory, paracrine, and immunomodulatory effects. The long-term effects of MFAT are still poorly understood: the aim of the present study is to demonstrate how hip articular injections with autologous MFAT can have an impact on clinical outcomes. METHODS: Seventy-one consecutive patients affected by early hip osteoarthritis underwent an ultrasound-guided hip injection of autologous MFAT between June 2017 and December 2018...
October 28, 2022: International Orthopaedics
https://read.qxmd.com/read/36198051/equine-umbilical-cord-mesenchymal-stem-cells-demonstrate-safety-and-efficacy-in-the-treatment-of-canine-osteoarthritis-a-randomized-placebo-controlled-trial
#15
JOURNAL ARTICLE
Eva Punzón, Raquel Salgüero, Xavier Totusaus, Cristian Mesa-Sánchez, Llorenç Badiella, María García-Castillo, Almudena Pradera
OBJECTIVE: To demonstrate the efficacy and safety of mesenchymal stem cells (MSCs) for xenogeneic use with intra-articular administration in dogs with osteoarthritis. ANIMALS: 80 client-owned dogs with naturally occurring osteoarthritis in elbow or hip. PROCEDURES: A multicentric, double-blinded, parallel, randomized and placebo-controlled clinical trial was performed. After intra-articular injection of equine umbilical cord MSCs, dogs were reexamined at weeks 4, 8, and 12 using a force platform (gait analysis), orthopedic assessment, and validated owner questionnaire...
October 4, 2022: Journal of the American Veterinary Medical Association
https://read.qxmd.com/read/36012474/the-kinesin-gene-kif26b-modulates-the-severity-of-post-traumatic-heterotopic-ossification
#16
JOURNAL ARTICLE
George A E Pickering, Favour Felix-Ilemhenbhio, Matthew J Clark, Klaudia Kocsy, Jonathan Simpson, Ilaria Bellantuono, Alison Gartland, Jeremy Mark Wilkinson, Konstantinos Hatzikotoulas, Endre Kiss-Toth
The formation of pathological bone deposits within soft tissues, termed heterotopic ossification (HO), is common after trauma. However, the severity of HO formation varies substantially between individuals, from relatively isolated small bone islands through to extensive soft tissue replacement by bone giving rise to debilitating symptoms. The aim of this study was to identify novel candidate therapeutic molecular targets for severe HO. We conducted a genome-wide scan in men and women with HO of varying severity following hip replacement for osteoarthritis...
August 16, 2022: International Journal of Molecular Sciences
https://read.qxmd.com/read/35754551/manufacturing-mesenchymal-stromal-cells-for-the-treatment-of-osteoarthritis-in-canine-patients-challenges-and-recommendations
#17
REVIEW
Ana Ivanovska, Mengyu Wang, Tarlan Eslami Arshaghi, Georgina Shaw, Joel Alves, Andrew Byrne, Steven Butterworth, Russell Chandler, Laura Cuddy, James Dunne, Shane Guerin, Rob Harry, Aidan McAlindan, Ronan A Mullins, Frank Barry
The recent interest in advanced biologic therapies in veterinary medicine has opened up opportunities for new treatment modalities with considerable clinical potential. Studies with mesenchymal stromal cells (MSCs) from animal species have focused on in vitro characterization (mostly following protocols developed for human application), experimental testing in controlled studies and clinical use in veterinary patients. The ability of MSCs to interact with the inflammatory environment through immunomodulatory and paracrine mechanisms makes them a good candidate for treatment of inflammatory musculoskeletal conditions in canine species...
2022: Frontiers in Veterinary Science
https://read.qxmd.com/read/35743928/in-vitro-characterization-of-the-human-skeletal-stem-cell-like-properties-of-primary-bone-derived-mesenchymal-stem-stromal-cells-in-patients-with-late-and-early-hip-osteoarthritis
#18
JOURNAL ARTICLE
Lara Jasenc, Klemen Stražar, Anže Mihelič, Rene Mihalič, Rihard Trebše, Gregor Haring, Matjaž Jeras, Janja Zupan
Human skeletal stem cells (hSSCs) were recently identified as podoplanin (PDPN)/CD73/CD164-positive and CD146-negative cells that decline with age, and play a role in the pathogenesis of osteoarthritis (OA). The aim of this study was to identify the hSSC-like properties of bone-derived mesenchymal stem/stromal cells (MSCs) of patients with late and early OA. Methods : First, we performed gene expression profiling for the hSSC markers in 32 patients with late and early OA, and donors without OA. Having identified the low expression of hSSC markers in late OA patients, we further performed trilineage differentiation and immunophenotyping for hSSC makers in the selected subsets from each donor group...
June 15, 2022: Life
https://read.qxmd.com/read/35727364/identification-of-kansl1-as-a-novel-pathogenic-gene-for-developmental-dysplasia-of-the-hip
#19
JOURNAL ARTICLE
Xiaowen Xu, Xinying Bi, Jing Wang, Ronghua Gui, Tengyan Li, Lianyong Li, Binbin Wang
Developmental dysplasia of the hip (DDH) is a common anomaly leading to adult osteoarthritis. Environmental and genetic factors contribute to DDH, but its exact genetic mechanism is unclear. In this study, we used whole exome sequencing to identify the causative gene of a DDH pedigree. A rare missense variant in KANSL1 (c.C767T; p.S256F) was identified as the pathogenic cause of DDH. Subsequent mutation screening showed another missense variant in 1 of 200 sporadic patients. Kansl1-mutated mice showed reduced chondrocytes in the acetabulum and a decrease in the cartilage matrix, which may be DDH phenotype-related abnormalities...
June 21, 2022: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://read.qxmd.com/read/35638400/photoactivated-leucocyte-rich-platelet-rich-plasma-treatment-in-reduction-of-bone-marrow-edema-in-hip-osteoarthritis
#20
JOURNAL ARTICLE
Jeimylo C de Castro, Elvira L Henares-Esguerra, Maria Bida Olivia S Tamayo-Shih, Daniel Wang, George C Chang Chien
Aim: To describe the successful treatment of bone marrow edema in the setting of hip osteoarthritis using ultrasound-guided injection of photoactivated leukocyte-rich platelet-rich plasma (LR-PRP). Setting: Outpatient clinic. Patient: 65-year old female with antalgic and listing gait. Case description: The patient presented with a 2-week history of left hip pain. Exam revealed restriction and pain at end range of motion. Imaging showed extensive bone marrow edema and hip effusion. The patient underwent four weekly photoactivated LR-PRP treatments...
August 2022: Regenerative Medicine
keyword
keyword
48657
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.