Wei Song, Zhijie Ma, Xin Wang, Yifei Wang, Di Wu, Chongyang Wang, Dan He, Lingzhi Kong, Weilin Yu, Jiao Jiao Li, Haiyan Li, Yaohua He
Osteoporotic tendon-to-bone healing (TBH) after rotator cuff repair (RCR) is a significant orthopedic challenge. Considering the aligned architecture of the tendon, inflammatory microenvironment at the injury site, and the need for endogenous cell/tissue infiltration, there is an imminent need for an ideal scaffold to promote TBH that has aligned architecture, ability to modulate inflammation, and macroporous structure. Herein, a novel macroporous hydrogel comprising sodium alginate/hyaluronic acid/small extracellular vesicles from adipose-derived stem cells (sEVs) (MHA-sEVs) with aligned architecture and immunomodulatory ability is fabricated...
October 22, 2023: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)