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https://www.readbyqxmd.com/read/28926394/armd-and-presumed-dangerous-commentary-on-an-article-by-gulraj-s-matharu-bsc-hons-mrcs-mres-et-al-blood-metal-ion-thresholds-to-identify-patients-with-metal-on-metal-hip-implants-at-risk-of-adverse-reactions-to-metal-debris-an-external-multicenter-validation
#1
COMMENT
https://www.readbyqxmd.com/read/28926383/mri-findings-in-patients-after-small-head-metal-on-metal-total-hip-arthroplasty-with-a-minimum-follow-up-of-10-years
#2
Tobias Reiner, Thuy D Do, Matthias C Klot, Fabian Hertzsch, Kirsten Seelmann, Matthias M Gaida, Marc-André Weber, Tobias Gotterbarm
BACKGROUND: Concern has been raised about the late onset of adverse reactions to metal debris (ARMD) in patients with a small-head metal-on-metal total hip replacement. The aims of this study were to assess the frequency and characteristic appearance of ARMD in patients with a small-head (28-mm) metal-on-metal total hip replacement and elevated blood ion levels (>1 μg/L) after a minimum follow-up of 10 years and to analyze the possible risk factors associated with the prevalence of these lesions...
September 20, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28926382/blood-metal-ion-thresholds-to-identify-patients-with-metal-on-metal-hip-implants-at-risk-of-adverse-reactions-to-metal-debris-an-external-multicenter-validation-study-of-birmingham-hip-resurfacing-and-corail-pinnacle-implants
#3
MULTICENTER STUDY
Gulraj S Matharu, Fiona Berryman, Andrew Judge, Aleksi Reito, Jamie McConnell, Olli Lainiala, Stephen Young, Antti Eskelinen, Hemant G Pandit, David W Murray
BACKGROUND: The authors of recent studies have reported newly devised implant-specific blood metal ion thresholds to predict adverse reactions to metal debris (ARMD) in patients who have undergone unilateral or bilateral metal-on-metal (MoM) hip arthroplasty. These thresholds were most effective for identifying patients at low risk of ARMD. We investigated whether these newly devised blood metal ion thresholds could effectively identify patients at risk of ARMD after MoM hip arthroplasty in an external cohort of patients...
September 20, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28887488/the-chemical-form-of-metal-species-released-from-corroded-taper-junctions-of-hip-implants-synchrotron-analysis-of-patient-tissue
#4
Anna Di Laura, Paul D Quinn, Vasiliki C Panagiotopoulou, Harry S Hothi, Johann Henckel, Jonathan J Powell, Fitim Berisha, Fernanda Amary, J Fred W Mosselmans, John A Skinner, Alister J Hart
The mechanisms of metal release from the articulation at the head cup bearing and the tapered junctions of orthopaedic hip implants are known to differ and the debris generated varies in size, shape and volume. Significantly less metal is lost from the taper junction between Cobalt-Chromium-Molybdenum (CoCrMo) and Titanium (Ti) components (fretting-corrosion dominant mechanism), when compared to the CoCrMo bearing surfaces (wear-corrosion dominant mechanism). Corrosion particles from the taper junction can lead to Adverse Reactions to Metal Debris (ARMD) similar to those seen with CoCrMo bearings...
September 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28790470/management-guidelines-for-metal-on-metal-hip-resurfacing-arthroplasty-a-strategy-on-followup
#5
Naoki Nakano, Andrea Volpin, Jonathan Bartlett, Vikas Khanduja
Despite the initial promise of metal-on-metal (MoM) implants as the ideal bearing surface for hip replacements and resurfacings, high short term failure rates due to an adverse reaction to metal debris (ARMD) have led to a dramatic reduction in the number of MoM implants used in the modern era. With over one million patients worldwide having undergone hip operations utilizing a MoM bearing surface, the long term outcomes for such patients remains unknown, and there is much debate as to the most effective management of these patients...
July 2017: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/28781016/blood-metal-ion-levels-have-limited-utility-in-the-surveillance-of-asymptomatic-large-head-metal-on-metal-total-hip-arthroplasties
#6
Manish Kiran, Catherine Armstrong, Deepak Shivarathre, Viju K Peter
BACKGROUND: Blood cobalt (Co) and chromium (Cr) ion levels have been used as surveillance tools for adverse reaction to metal debris (ARMD) in metal-on-metal (MoM) articulations with varying thresholds in different countries. The aim of our study is to present the serial 12-year blood Co and Cr levels in a cohort of MoM total hip arthroplasties (THAs) with femoral head size ≥36 mm and analyze their utility in asymptomatic patients at current thresholds. METHODS: A total of 256 patients with unilateral MoM THA with femoral head size ≥36 mm were included in this study with data collected prospectively...
July 20, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28768778/which-factors-influence-the-rate-of-failure-following-metal-on-metal-hip-arthroplasty-revision-surgery-performed-for-adverse-reactions-to-metal-debris-an-analysis-from-the-national-joint-registry-for-england-and-wales
#7
MULTICENTER STUDY
G S Matharu, A Judge, H G Pandit, D W Murray
AIMS: To determine the outcomes following revision surgery of metal-on-metal hip arthroplasties (MoMHA) performed for adverse reactions to metal debris (ARMD), and to identify factors predictive of re-revision. PATIENTS AND METHODS: We performed a retrospective observational study using National Joint Registry (NJR) data on 2535 MoMHAs undergoing revision surgery for ARMD between 2008 and 2014. The outcomes studied following revision were intra-operative complications, mortality and re-revision surgery...
August 2017: Bone & Joint Journal
https://www.readbyqxmd.com/read/28710154/outcomes-following-revision-surgery-performed-for-adverse-reactions-to-metal-debris-in-non-metal-on-metal-hip-arthroplasty-patients-analysis-of-185-revisions-from-the-national-joint-registry-for-england-and-wales
#8
G S Matharu, A Judge, D W Murray, H G Pandit
OBJECTIVES: Few studies have assessed outcomes following non-metal-on-metal hip arthroplasty (non-MoMHA) revision surgery performed for adverse reactions to metal debris (ARMD). We assessed outcomes following non-MoMHA revision surgery performed for ARMD, and identified predictors of re-revision. METHODS: We performed a retrospective observational study using data from the National Joint Registry for England and Wales. All non-MoMHAs undergoing revision surgery for ARMD between 2008 and 2014 were included (185 hips in 185 patients)...
July 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28707830/-patients-with-metal-on-metal-hip-arthroplasty-evaluation-and-management-of-complications
#9
Olivier Guyen, Christophe Tissot
The potentially severe complications related to metal-on-metal (MoM) hip replacements have led to a dramatic decrease of their use. Large diameter heads are more likely to fail than smaller diameters, but complications have been described even with « small » diameters. Therefore, monitoring of MoM arthroplasties is mandatory. This includes physical examination, X-Rays, metal ion levels, and potentially cross-sectional imaging. Despite pathophysiology of adverse reactions to metal debris (ARMD) is better understood, their evolution and the potential systemic complications remain unclear...
December 14, 2016: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28660477/correlation-of-serum-metal-ion-levels-with-pathological-changes-of-armd-in-failed-metal-on-metal-hip-resurfacing-arthroplasties
#10
George Grammatopoulos, Mitsuru Munemoto, Athanasios Pollalis, Nicholas A Athanasou
BACKGROUND: Metal-on-metal-hip-resurfacing arthroplasties (MoMHRAs) have been associated with an increased failure rates due to an adverse-response-to-metal-debris (ARMD) associated with a spectrum of pathological features. Serum levels of cobalt (Co) and chromium (Cr) are used to assess MoMHRAs, with regard to ARMD, but it is not certain whether ion levels correlate with pathological changes in periprosthetic tissues. METHODS: Serum Co and Cr levels were correlated with histological findings in 38 revised MoMHRAs (29 pseudotumour cases and 9 non-pseudotumour cases revised for pain)...
August 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/28616984/oh-stretching-overtone-induced-dynamics-in-hso3f-from-reactive-molecular-dynamics-simulations
#11
Sebastian Brickel, Markus Meuwly
The OH-stretch induced dynamics in fluorosulfonic acid (HSO3F) is characterized from a statistically significant number of trajectories using multisurface adiabatic reactive molecular dynamics (MS-ARMD) simulations. The global reactive potential energy surface, which describes H-transfer and HF-elimination, is parametrized at the MP2/6-311G++(2p,2d) level of theory with an accuracy of better than 1 kcal/mol. Excitation along the OH-local mode leads to H-transfer dynamics but elimination of HF is only observed for excitations with ν ≥ 6 for 1 out of 5000 trajectories...
June 29, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28613221/clinicopathologic-correlation-of-retinal-angiomatous-proliferation-treated-with-ranibizumab
#12
Alison H Skalet, Audra K Miller, Michael L Klein, Andreas K Lauer, David J Wilson
PURPOSE: To describe histopathologic features of an eye with retinal angiomatous proliferation (RAP) secondary to age-related macular degeneration treated with serial ranibizumab injections and to correlate these findings with spectral domain optical coherence tomography. METHODS: Histopathologic features from serial sections through the globe of a 93-year-old man with age-related macular degeneration were studied and compared with spectral domain optical coherence tomography images obtained 7 weeks before his death...
August 2017: Retina
https://www.readbyqxmd.com/read/28449645/24-month-clinical-outcomes-of-a-treat-and-extend-regimen-with-ranibizumab-for-wet-age-related-macular-degeneration-in-a-real-life-setting
#13
Athanasios Vardarinos, Nitin Gupta, Raazia Janjua, Abigail Iron, Theo Empeslidis, Konstantinos T Tsaousis
BACKGROUND: To evaluate the clinical effectiveness and analyze the outcomes of a treat-and-extend (T&E) treatment regimen with ranibizumab for wet age-related macular degeneration (ARMD) in real life clinical settings over the first 2 years (24 months) of treatment. METHODS: Retrospective analysis of visual acuity, spectral domain optical coherence tomography (SD-OCT) parameters and treatment burden data of 56 eyes of 54 unselected treatment naive patients diagnosed with exudative ARMD...
April 27, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28424788/fully-automated-robust-system-to-detect-retinal-edema-central-serous-chorioretinopathy-and-age-related-macular-degeneration-from-optical-coherence-tomography-images
#14
Samina Khalid, M Usman Akram, Taimur Hassan, Ammara Nasim, Amina Jameel
Maculopathy is the excessive damage to macula that leads to blindness. It mostly occurs due to retinal edema (RE), central serous chorioretinopathy (CSCR), or age related macular degeneration (ARMD). Optical coherence tomography (OCT) imaging is the latest eye testing technique that can detect these syndromes in early stages. Many researchers have used OCT images to detect retinal abnormalities. However, to the best of our knowledge, no research that presents a fully automated system to detect all of these macular syndromes is reported...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28378001/adverse-reaction-to-metal-debris-with-concomitant-incidental-crystalline-arthropathy-in-hip-arthroplasty
#15
Edward J Testa, Brian J McGrory
Adverse reaction to metal debris (ARMD) is a known cause of failed metal in hip arthroplasty. Diagnosis of this type of prosthesis failure may be difficult, and the hallmark is an abnormally elevated serum cobalt level. Concomitant diagnoses may also be present, such as infection, instability, and loosening, and this may confuse interpretation of abnormal laboratories. We present here, for the first time, 2 patients with ARMD and crystalline arthropathy. In each case, the patient chose surgery for ARMD, with resolution of symptoms and no recurrence of the crystalline arthropathy...
March 2017: Arthroplasty Today
https://www.readbyqxmd.com/read/28344888/pre-emptive-and-therapeutic-adoptive-immunotherapy-for-nasopharyngeal-carcinoma-phenotype-and-effector-function-of-t-cells-impact-on-clinical-response
#16
Corey Smith, Victor Lee, Andrea Schuessler, Leone Beagley, Sweera Rehan, Janice Tsang, Vivian Li, Randal Tiu, David Smith, Michelle A Neller, Katherine K Matthews, Emma Gostick, David A Price, Jacqueline Burrows, Glen M Boyle, Daniel Chua, Benedict Panizza, Sandro V Porceddu, John Nicholls, Dora Kwong, Rajiv Khanna
Adoptive T cell therapy has emerged as a powerful strategy to treat human cancers especially haematological malignancies. Extension of these therapies to solid cancers remains a significant challenge especially in the context of defining immunological correlates of clinical responses. Here we describe results from a clinical study investigating autologous Epstein-Barr virus (EBV)-specific T cells generated using a novel AdE1-LMPpoly vector to treat patients with nasopharyngeal carcinoma (NPC) either pre-emptively in at-risk patients with no or minimal residual disease (N/MRD) or therapeutically in patients with active recurrent/metastatic disease (ARMD)...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28320566/the-utility-of-metal-ion-trends-in-predicting-revision-in-metal-on-metal-total-hip-arthroplasty
#17
Bayard C Carlson, Andrew J Bryan, Nazly T Carrillo-Villamizar, Rafael J Sierra
BACKGROUND: There is a paucity of data examining metal ion levels over time. METHODS: We retrospectively reviewed 59 patients (69 hips) with an articular surface replacement total hip arthroplasty. We reviewed prerevision cobalt and chromium concentrations over time. RESULTS: Seventy-one percent of patients who were revised and had multiple ion measurements (12/17) demonstrated increasing cobalt ion levels or elevated ion levels over time...
February 20, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28298893/bis-retinoid-a2e-induces-an-increase-of-basic-fibroblast-growth-factor-via-inhibition-of-extracellular-signal-regulated-kinases-1-2-pathway-in-retinal-pigment-epithelium-cells-and-facilitates-phagocytosis
#18
Delphine Balmer, Linda Bapst-Wicht, Aswin Pyakurel, Martine Emery, Natacha Nanchen, Christian G Bochet, Raphael Roduit
Age-related macular degeneration (ARMD) is the leading cause of vision loss in developed countries. Hallmarks of the disease are well known; indeed, this pathology is characterized by lipofuscin accumulation, is principally composed of lipid-containing residues of lysosomal digestion. The N-retinyl-N-retinylidene ethanolamine (A2E) retinoid which is thought to be a cytotoxic component for RPE is the best-characterized component of lipofuscin so far. Even if no direct correlation between A2E spatial distribution and lipofuscin fluorescence has been established in aged human RPE, modified forms or metabolites of A2E could be involved in ARMD pathology...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28246095/explant-analysis-of-the-biomet-magnum-recap-metal-on-metal-hip-joint
#19
S C Scholes, B J Hunt, V M Richardson, D J Langton, E Smith, T J Joyce
OBJECTIVES: The high revision rates of the DePuy Articular Surface Replacement (ASR) and the DePuy ASR XL (the total hip arthroplasty (THA) version) have led to questions over the viability of metal-on-metal (MoM) hip joints. Some designs of MoM hip joint do, however, have reasonable mid-term performance when implanted in appropriate patients. Investigations into the reasons for implant failure are important to offer help with the choice of implants and direction for future implant designs...
February 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28225799/sf-6d-utility-values-for-the-better-and-worse-seeing-eye-for-health-states-based-on-the-snellen-equivalent-in-patients-with-age-related-macular-degeneration
#20
Martijn S Visser, Sankha Amarakoon, Tom Missotten, Reinier Timman, Jan J Busschbach
OBJECTIVE: Economic evaluations in wet age-related macular degeneration (ARMD) is hampered as often utility values for solely one eye are used, mostly the better-seeing eye (BSE). Moreover, frequently chosen methods rely on patient values and/or disease specific measures, while economic evaluations prefer generic quality of life (QoL) measures based on societal preferences. The generic QoL utility instrument EQ-5D has shown to be insensitive for differences in visual acuity. The aim of this study was therefore to provide societal utility values, using the generic SF-6D, for health states acknowledging both BSE and worse-seeing eye (WSE)...
2017: PloS One
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