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https://www.readbyqxmd.com/read/27877085/the-evolving-functions-of-autophagy-in-ocular-health-a-double-edged-sword
#1
REVIEW
Peiwei Chai, Hongyan Ni, He Zhang, Xianqun Fan
Autophagy plays an adaptive role in cell survival, development, differentiation and intracellular homeostasis. Autophagy is recognized as a 'self-cannibalizing' process that is active during stresses such as starvation, chemotherapy, infection, ageing, and oxygen shortage to protect organisms from various irritants and to regenerate materials and energy. However, autophagy can also lead to a form of programmed cell death distinct from apoptosis. Components of the autophagic pathway are constitutively expressed at a high level in the eye, including in the cornea, lens, retina, and orbit...
2016: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/27835611/effect-of-cobalt-mediated-toll-like-receptor-4-activation-on-inflammatory-responses-in-endothelial-cells
#2
Sami A Anjum, Helen Lawrence, James P Holland, John A Kirby, David J Deehan, Alison J Tyson-Capper
Cobalt-containing metal-on-metal hip replacements are associated with adverse reactions to metal debris (ARMD), including inflammatory pseudotumours, osteolysis, and aseptic implant loosening. The exact cellular and molecular mechanisms leading to these responses are unknown. Cobaltions (Co2+) activate human Toll-like receptor 4 (TLR4), an innate immune receptor responsible for inflammatory responses to Gram negative bacterial lipopolysaccharide (LPS).We investigated the effect of Co2+-mediated TLR4 activation on human microvascular endothelial cells (HMEC-1), focusing on the secretion of key inflammatory cytokines and expression of adhesion molecules...
November 9, 2016: Oncotarget
https://www.readbyqxmd.com/read/27829734/601-metal-on-metal-total-hip-replacements-with-36%C3%A2-mm-heads-a-5-minimum-year-follow-up-levels-of-armd-remain-low-despite-a-comprehensive-screening-program
#3
Amit Atrey, Alister Hart, Nasir Hussain, Jonathon Waite, Andrew J Shepherd, Steve Young
BACKGROUND: We conducted a retrospective study to assess the clinical outcome, failure rate, and reason for failure of a large consecutive series of 36 mm MoM Corail/Pinnacle total hip replacements (THRs). METHODS: Between 2006 and 2011, 601 consecutive 36 mm MoM THRs were performed (585 patients). Patients were followed according to the UK Medicines and Healthcare Products Regulatory Agency (MHRA) guidelines. All patients were accounted for and 469 patients (78%) were clinically and radiographically assessed...
March 2017: Journal of Orthopaedics
https://www.readbyqxmd.com/read/27803220/can-blood-metal-ion-levels-be-used-to-identify-patients-with-bilateral-birmingham-hip-resurfacings-who-are-at-risk-of-adverse-reactions-to-metal-debris
#4
G S Matharu, F Berryman, L Brash, P B Pynsent, D J Dunlop, R B C Treacy
AIMS: We investigated whether blood metal ion levels could effectively identify patients with bilateral Birmingham Hip Resurfacing (BHR) implants who have adverse reactions to metal debris (ARMD). PATIENTS AND METHODS: Metal ion levels in whole blood were measured in 185 patients with bilateral BHRs. Patients were divided into those with ARMD who either had undergone a revision for ARMD or had ARMD on imaging (n = 30), and those without ARMD (n = 155). Receiver operating characteristic analysis was used to determine the optimal thresholds of blood metal ion levels for identifying patients with ARMD...
November 2016: Bone & Joint Journal
https://www.readbyqxmd.com/read/27759474/poor-10-year-survivorship-of-hip-resurfacing-arthroplasty
#5
Matti Seppänen, Mikko Karvonen, Petri Virolainen, Ville Remes, Pekka Pulkkinen, Antti Eskelinen, Antti Liukas, Keijo T Mäkelä
Background and purpose - In a previous registry report, short-term implant survival of hip resurfacing arthroplasty (HRA) in Finland was found to be comparable to that of total hip arthroplasty (THA). Since then, it has become evident that adverse reactions to metal debris (ARMDs) may also be associated with HRA, not only with large-diameter head metal-on-metal THA. The aim of the study was to assess medium- to long-term survivorship of HRA based on the Finnish Arthroplasty Register (FAR). Patients and methods - 5,068 HRAs performed during the period 2001-2013 in Finland were included...
December 2016: Acta Orthopaedica
https://www.readbyqxmd.com/read/27748300/homocysteine-its-metabolite-homocysteine-thiolactone-deficiency-of-copper-in-patients-with-age-related-macular-degeneration-a-pilot-study
#6
Muthuvel Bharathselvi, Sayantan Biswas, Rajiv Raman, Radhakrishnan Selvi, Karunakaran Coral, Angayarkanni Narayanansamy, Sivaramakrishnan Ramakrishnan, Konerirajapuram N Sulochana
BACKGROUND & OBJECTIVES: Age related macular degeneration (ARMD) is a leading cause of blindness, particularly in persons above 60 yr of age. Homocysteine is implicated in many ocular diseases including ARMD. This study was undertaken to assess the status and relationship between plasma homocysteine, homocysteine - thiolactone, homocysteinylated protein and copper levels in patients with ARMD. METHODS: A total of 16 patients with ARMD and 16 age-matched controls were recruited for the study...
June 2016: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/27729758/the-relationship-between-neutrophil-to-lymphocyte-ratio-and-age-related-macular-degeneration
#7
Bengi Ece Kurtul, Pinar Altiaylik Ozer
PURPOSE: To investigate the possible associations of neutrophil-to-lymphocyte ratio (NLR) and high sensitivity C-reactive protein (hs-CRP) level with age-related macular degeneration (ARMD). METHODS: Patients were divided to three groups of 40 patients with non-neovascular ARMD (group 1), 40 patients with neovascular ARMD (group 2), and 40 healthy control subjects (group 3). The neutrophil and lymphocyte counts were evaluated using an ABX Pentra DF120/USA biochemical analyzer, and hs-CRP levels were measured using a Beckman Coulter Immage 800...
October 2016: Korean Journal of Ophthalmology: KJO
https://www.readbyqxmd.com/read/27704611/the-variation-in-taper-surface-roughness-for-a-single-design-effects-the-wear-rate-in-total-hip-arthroplasty
#8
Robert K Whittaker, Harry S Hothi, Antti Eskelinen, Gordon W Blunn, John A Skinner, Alister J Hart
Material loss from the head-stem taper junction of total hip arthroplasty (THA) is implicated in adverse reactions to metal debris (ARMD); the mechanisms for this are multi-factorial. We investigated the relationship between the roughness of the 'as manufactured' taper surface and the wear rate from this junction. 50 retrieved Pinnacle metal-on-metal (MOM) bearings paired with a Corail stem were included in the study. Multivariable statistical analysis was performed to determine the influence of taper roughness on material loss rate after controlling for other confounding surgical, implant and patient factors...
October 5, 2016: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/27612918/blood-metal-ion-levels-are-not-a-useful-test-for-adverse-reactions-to-metal-debris-a-systematic-review-and-meta-analysis
#9
M Pahuta, J M Smolders, J L van Susante, J Peck, P R Kim, P E Beaule
OBJECTIVES: Alarm over the reported high failure rates for metal-on-metal (MoM) hip implants as well as their potential for locally aggressive Adverse Reactions to Metal Debris (ARMDs) has prompted government agencies, internationally, to recommend the monitoring of patients with MoM hip implants. Some have advised that a blood ion level >7 µg/L indicates potential for ARMDs. We report a systematic review and meta-analysis of the performance of metal ion testing for ARMDs. METHODS: We searched MEDLINE and EMBASE to identify articles from which it was possible to reconstruct a 2 × 2 table...
September 2016: Bone & Joint Research
https://www.readbyqxmd.com/read/27580527/failure-rates-of-asian-type-anatomic-medullary-locking-stemmed-metal-on-metal-total-hip-replacement-a-cause-for-adverse-tissue-reactions-to-metal-debris-armd
#10
Masaru Nakamura, Tateaki Shimakawa, Shunji Nakano, Takashi Chikawa, Shinji Yoshioka, Masahiro Kashima, Shunichi Toki, Hidehisa Horiguchi, Koichi Sairyo
BACKGROUND: Adverse tissue reaction to metal debris (ARMD) as a secondary complication of Metal-on-metal total hip replacement (MoM THR) has been of concern. We have been performing cementless MoM THR using an Asian-type anatomic medullary locking (AML) stem. The purpose of this study is to examine the incident rate of ARMD, and the implant survival rate. METHODS: The study included 187 patients (211 hip joints) who underwent MoM THR between February 2007 and November 2009 at our hospital and who were followed up for a minimum of 6 years...
August 28, 2016: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/27498633/empirical-force-fields-for-mechanistic-studies-of-chemical-reactions-in-proteins
#11
A K Das, M Meuwly
Following chemical reactions in atomistic detail is one of the most challenging aspects of current computational approaches to chemistry. In this chapter the application of adiabatic reactive MD (ARMD) and its multistate version (MS-ARMD) are discussed. Both methods allow to study bond-breaking and bond-forming processes in chemical and biological processes. Particular emphasis is put on practical aspects for applying the methods to investigate the dynamics of chemical reactions. The chapter closes with an outlook of possible generalizations of the methods discussed...
2016: Methods in Enzymology
https://www.readbyqxmd.com/read/27433034/long-term-outcomes-of-combination-photodynamic-therapy-with-ranibizumab-or-bevacizumab-for-treatment-of-wet-age-related-macular-degeneration
#12
Ekta Rishi, Pukhraj Rishi, Vishal Sharma, Vikram Koundanya, Renu Athanikar
AIM: To evaluate and compare the efficacy of combination of ranibizumab or bevacizumab with photodynamic therapy (PDT) in treating choroidal neovascularization (CNV) secondary to age-related macular degeneration (ARMD) on long-term follow-up. MATERIALS AND METHODS: Of 42 eyes, 18 were treated with bevacizumab (Group A) and 24 with ranibizumab (Group B) in combination with verteporfin PDT. Treatment was initiated after informed consent. Complete ophthalmic examination including optical coherence tomography (OCT) was performed at presentation, 1 month, 3 months, and subsequent follow-up visits...
May 2016: Oman Journal of Ophthalmology
https://www.readbyqxmd.com/read/27428740/scarb1-rs5888-is-associated-with-the-risk-of-age-related-macular-degeneration-susceptibility-and-an-impaired-macular-area
#13
Daiva Stanislovaitiene, Dalia Zaliuniene, Algimantas Krisciukaitis, Robertas Petrolis, Alina Smalinskiene, Vita Lesauskaite, Abdonas Tamosiunas, Vaiva Lesauskaite
BACKGROUND: Age-related macular degeneration (ARMD), a progressive retinal disease, is responsible for an impaired central vision in about 180 million people worldwide. Current options for ARMD prevention and treatment are limited due to an incomplete understanding of disease etiopathogenesis. We aimed to test the hypothesis that the single nucleotide polymorphism rs5888 of SCARB1 gene reflecting lipid and antioxidant micronutrient metabolism pathways is associated with ARMD susceptibility and to evaluate if there is any relation between SCARB1 rs5888 and the macular lesion area...
July 18, 2016: Ophthalmic Genetics
https://www.readbyqxmd.com/read/27328169/eye-disease-in-patients-with-diabetes-screened-with-telemedicine
#14
Dong-Wouk Park, Steven L Mansberger
BACKGROUND: Telemedicine with nonmydriatic cameras can detect not only diabetic retinopathy but also other eye disease. OBJECTIVE: To determine the prevalence of eye diseases detected by telemedicine in a population with a high prevalence of minority and American Indian/Alaskan Native (AI/AN) ethnicities. SUBJECTS AND METHODS: We recruited diabetic patients 18 years and older and used telemedicine with nonmydriatic cameras to detect eye disease...
June 21, 2016: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
https://www.readbyqxmd.com/read/27293285/midterm-results-of-36-mm-metal-on-metal-total-hip-arthroplasty
#15
Hawar Akrawi, Fahad S Hossain, Stefan Niculescu, Zaid Hashim, Arron Biing Ng, Ajit Shetty
BACKGROUND: Despite the many perceived benefits of metal-on-metal (MoM) articulation in total hip arthroplasty (THA), there have been growing concerns about metallosis and adverse reaction to metal debris (ARMD). Analysis of size 36 mm MoM articulation THAs is presented. These patients were evaluated for patient characteristics, relationship between blood metal ions levels and the inclination as well as the version of acetabular component, cumulative survival probability at final followup and functional outcome at final followup...
May 2016: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/27254844/military-occupational-outcomes-in-canadian-armed-forces-personnel-with-and-without-deployment-related-mental-disorders
#16
David Boulos, Mark A Zamorski
OBJECTIVE: Mental disorders are common in military organizations, and these frequently lead to functional impairments that can interfere with duties and lead to costly attrition. In Canada, the military mental health system has received heavy investment to improve occupational outcomes. We investigated military occupational outcomes of diagnosed mental disorders in a cohort of 30,513 personnel who deployed on the Afghanistan mission. METHODS: Cohort members were military personnel who deployed on the Afghanistan mission from 2001 to 2008...
June 2016: Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie
https://www.readbyqxmd.com/read/27235513/pseudotumour-formation-and-subsequent-resolution-in-metal-on-metal-total-hip-arthroplasty-following-revision-instructional-review-and-an-illustrative-case-report-with-revision-using-a-dual-mobility-design
#17
REVIEW
A A Sassoon, R L Barrack
The use of large-diameter metal-on-metal (MoM) components in total hip arthroplasty (THA) is associated with an increased risk of early failure due to adverse local tissue reaction to metal debris (ARMD) in response to the release of metal ions from the bearing couple and/or head-neck taper corrosion. The aim of this paper was to present a review of the incidence and natural history of ARMD and the forms of treatment, with a focus on the need for and extent of resection or debulking of the pseudotumour. An illustrative case report is presented of a patient with an intra-pelvic pseudotumour associated with a large diameter MoM THA, which was treated successfully with revision of the bearing surface to a dual mobility couple and retention of the well-fixed acetabular and femoral components...
June 2016: Bone & Joint Journal
https://www.readbyqxmd.com/read/27227536/the-inflammatory-phenotype-in-failed-metal-on-metal-hip-arthroplasty-correlates-with-blood-metal-concentrations
#18
Erja-Leena Paukkeri, Riku Korhonen, Mari Hämäläinen, Marko Pesu, Antti Eskelinen, Teemu Moilanen, Eeva Moilanen
INTRODUCTION: Hip arthroplasty is the standard treatment of a painful hip destruction. The use of modern metal-on-metal (MOM) bearing surfaces gained popularity in total hip arthroplasties during the last decade. Recently, worrisome failures due to adverse reaction to metal debris (ARMD), including pseudotumor response, have been widely reported. However, the pathogenesis of this reaction remains poorly understood. The aim of the present study was to investigate the ARMD response by flow cytometry approach...
2016: PloS One
https://www.readbyqxmd.com/read/27225587/inhibition-of-phagocytic-activity-of-arpe-19-cells-by-free-radical-mediated-oxidative-stress
#19
Magdalena M Olchawa, Anna K Pilat, Grzegorz M Szewczyk, Tadeusz Jan Sarna
Oxidative stress is a main factor responsible for key changes leading to the onset of age-related macular degeneration (ARMD) that occur in the retinal pigment epithelium (RPE), which is involved in phagocytosis of photoreceptor outer segments (POS). In this study, hydrogen peroxide (H2O2), H2O2 and iron ions (Fe) or rose Bengal (RB) in the presence of NADH and Fe were used to model free radical mediated oxidative stress to test if free radicals and singlet oxygen have different efficiency to inhibit phagocytosis of ARPE-19 cells...
August 2016: Free Radical Research
https://www.readbyqxmd.com/read/27209084/immune-response-in-adverse-reactions-to-metal-debris-following-metal-on-metal-total-hip-arthroplasty
#20
Masahiro Hasegawa, Takahiro Iino, Akihiro Sudo
BACKGROUND: The purpose of the present study was to determine whether T cell-mediated type IV hypersensitivity reactions could be a major cause of adverse reaction to metal debris (ARMD) after metal-on-metal total hip arthroplasty (THA). METHODS: Thirteen patients (1 man and 12 women; mean age 68 years, age range 60 to 83 years) with ARMD underwent revision surgery following metal-on-metal THA (15 hips). Lymphocyte stimulation testing was conducted. Periprosthetic tissue specimens underwent immunohistochemical studies...
2016: BMC Musculoskeletal Disorders
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