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https://www.readbyqxmd.com/read/28225799/sf-6d-utility-values-for-the-better-and-worse-seeing-eye-for-health-states-based-on-the-snellen-equivalent-in-patients-with-age-related-macular-degeneration
#1
Martijn S Visser, Sankha Amarakoon, Tom Missotten, Reinier Timman, Jan J Busschbach
OBJECTIVE: Economic evaluations in wet age-related macular degeneration (ARMD) is hampered as often utility values for solely one eye are used, mostly the better-seeing eye (BSE). Moreover, frequently chosen methods rely on patient values and/or disease specific measures, while economic evaluations prefer generic quality of life (QoL) measures based on societal preferences. The generic QoL utility instrument EQ-5D has shown to be insensitive for differences in visual acuity. The aim of this study was therefore to provide societal utility values, using the generic SF-6D, for health states acknowledging both BSE and worse-seeing eye (WSE)...
2017: PloS One
https://www.readbyqxmd.com/read/28218371/adverse-reaction-to-metal-debris-in-a-consecutive-series-of-durom%C3%A2-hip-resurfacing-pseudotumour-incidence-and-metal-ion-concentration
#2
Albrecht Hartmann, Jan-Dirk Kieback, Jörg Lützner, Klaus-Peter Günther, Jens Goronzy
INTRODUCTION: The aim of this study was to evaluate the incidence of adverse reactions to metal debris (ARMD) in a consecutive series of DUROM™ Hip Resurfacing Arthroplasty (HRA) at mid-term follow-up. METHODS: Between October 2003 and March 2007 a total of 134 consecutive DUROM™ HRA in 121 patients were performed at our institution. Follow-up could be obtained in 101 unrevised patients (83%) at a mean time of 8.51 ± 0.97 years postoperatively and included patient-related outcome measurement, plain radiographs, MARS-MRI as well as whole blood metal ion assessment...
February 8, 2017: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/28165602/outcome-of-revision-arthroplasty-for-failed-metal-on-metal-total-hip-replacements-is-there-a-relation-with-metal-ions
#3
Hafiz J Iqbal, Waheeb A K Al-Azzani, Esther Jackson-Taylor, Elizabeth Clatworthy, Alun John
PURPOSE: We aimed to assess the early outcome following revision arthroplasty for failed metal-on-metal (MoM) total hip replacements (THR) due to adverse reaction to metal debris (ARMD). METHODS: We reviewed 106 consecutive revision arthroplasties. Case notes and radiological investigations were reviewed to assess the complications. Oxford Hip Score (OHS) and Euroqol (EQ-5D-3L) scores were used to assess the functional outcome and improvement of quality of life...
February 3, 2017: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/28122467/high-blood-metal-ion-levels-in-19-of-22-patients-with-metal-on-metal-hinge-knee-replacements
#4
Minna Laitinen, Jyrki Nieminen, Aleksi Reito, Toni-Karri Pakarinen, Piia Suomalainen, Konsta Pamilo, Jyrki Parkkinen, Tonis Lont, Antti Eskelinen
Background and purpose - There has been increasing alarm regarding metal-on-metal (MoM) joint replacements leading to elevated levels of metal ions and adverse reactions to metal debris (ARMDs). There is little information available concerning the prevalence of and risk factors for these adverse reactions, except with MoM hip joint replacements. We determined the levels of metal ions in blood and the rate of revision due to ARMDs in patients treated with MoM hinge total knee arthroplasty (TKA). Patients and methods - 22 patients with TKAs and MoM hinge connecting mechanisms were studied for whole-blood chromium and cobalt levels at 6 months, 1 year, and/or ≥2 years after surgery...
January 26, 2017: Acta Orthopaedica
https://www.readbyqxmd.com/read/27994182/identification-of-a-novel-15-5-kb-shox-deletion-associated-with-marked-intrafamilial-phenotypic-variability-and-analysis-of-its-molecular-origin
#5
Angelos Alexandrou, Ioannis Papaevripidou, Kyriakos Tsangaras, Ioanna Alexandrou, Marios Tryfonidis, Violetta Christophidou-Anastasiadou, Eleni Zamba-Papanicolaou, George Koumbaris, Vassos Neocleous, Leonidas A Phylactou, Nicos Skordis, George A Tanteles, Carolina Sismani
Haploinsufficiency of the short stature homeobox contaning SHOX gene has been shown to result in a spectrum of phenotypes ranging from Leri-Weill dyschondrosteosis (LWD) at the more severe end to SHOX-related short stature at the milder end of the spectrum. Most alterations are whole gene deletions, point mutations within the coding region, or microdeletions in its flanking sequences. Here, we present the clinical and molecular data as well as the potential molecular mechanism underlying a novel microdeletion, causing a variable SHOX-related haploinsufficiency disorder in a three-generation family...
December 2016: Journal of Genetics
https://www.readbyqxmd.com/read/27992643/recall-of-the-asr-xl-head-and-hip-resurfacing-systems
#6
Werner Maurer-Ertl, Joerg Friesenbichler, Lukas A Holzer, Lukas Leitner, Kathrin Ogris, Michael Maier, Andreas Leithner
At the beginning of the 21st century, use of large-diameter, metal-on-metal devices was a popular procedure for hip replacement in young and physically active patients; however, within a few years, the number of revisions increased, resulting in a worldwide recall for the articular surface replacement (ASR) system. Complication rates for the ASR devices implanted at the authors' department are reported, with revision rates of 32% and 30% in the ASR XL Head and ASR Resurfacing groups, respectively. Reasons for revision surgery were serum metal ion elevation, luxation or subluxation, aseptic loosening, soft tissue compromise (adverse reactions to metal debris [ARMD]), and infection...
December 19, 2016: Orthopedics
https://www.readbyqxmd.com/read/27988181/incidence-of-adverse-reactions-to-metal-debris-from-28-mm-metal-on-metal-total-hip-arthroplasties-with-minimum-10-years-of%C3%A2-follow-up-clinical-laboratory-and-ultrasound-assessment-of-44%C3%A2-cases
#7
Béchir Ayoub, Sophie Putman, Pierre Cholewinski, Amandine Paris, Henri Migaud, Julien Girard
BACKGROUND: Total hip arthroplasty with metal-on-metal (MoM) bearings has been suspected to cause adverse reactions to metal debris (ARMD), with the incidence varying greatly by implant type and patient gender. The prevalence of ARMD from small-diameter MoM bearings in women is unknown, especially after 10 years of follow-up (FU). METHODS: Cementless 28-mm MoM total hip arthroplasty bearings (Metasul) were implanted consecutively in 42 active women between 1996 and 2002...
November 15, 2016: Journal of Arthroplasty
https://www.readbyqxmd.com/read/27955657/adverse-reactions-to-metal-debris-occur-with-all-types-of-hip-replacement-not-just-metal-on-metal-hips-a-retrospective-observational-study-of-3340-revisions-for-adverse-reactions-to-metal-debris-from-the-national-joint-registry-for-england-wales-northern-ireland
#8
Gulraj S Matharu, Hemant G Pandit, David W Murray, Andrew Judge
BACKGROUND: Adverse reactions to metal debris (ARMD) have resulted in the high short-term failure rates observed with metal-on-metal hip replacements. ARMD has recently been reported in non-metal-on-metal total hip replacements (non-MoM THRs) in a number of small cohort studies. However the true magnitude of this complication in non-MoM THRs remains unknown. We used a nationwide database to determine the risk of ARMD revision in all non-MoM THRs, and compared patient and surgical factors associated with ARMD revision between non-MoM and MoM hips...
December 13, 2016: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/27918307/vegf-regulates-local-inhibitory-complement-proteins-in-the-eye-and-kidney
#9
Lindsay S Keir, Rachel Firth, Lyndsey Aponik, Daniel Feitelberg, Susumu Sakimoto, Edith Aguilar, Gavin I Welsh, Anna Richards, Yoshihiko Usui, Simon C Satchell, Valeryia Kuzmuk, Richard J Coward, Jonathan Goult, Katherine R Bull, Ruchi Sharma, Kapil Bharti, Peter D Westenskow, Iacovos P Michael, Moin A Saleem, Martin Friedlander
Outer retinal and renal glomerular functions rely on specialized vasculature maintained by VEGF that is produced by neighboring epithelial cells, the retinal pigment epithelium (RPE) and podocytes, respectively. Dysregulation of RPE- and podocyte-derived VEGF is associated with neovascularization in wet age-related macular degeneration (ARMD), choriocapillaris degeneration, and glomerular thrombotic microangiopathy (TMA). Since complement activation and genetic variants in inhibitory complement factor H (CFH) are also features of both ARMD and TMA, we hypothesized that VEGF and CFH interact...
January 3, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/27877085/the-evolving-functions-of-autophagy-in-ocular-health-a-double-edged-sword
#10
REVIEW
Peiwei Chai, Hongyan Ni, He Zhang, Xianqun Fan
Autophagy plays an adaptive role in cell survival, development, differentiation and intracellular homeostasis. Autophagy is recognized as a 'self-cannibalizing' process that is active during stresses such as starvation, chemotherapy, infection, ageing, and oxygen shortage to protect organisms from various irritants and to regenerate materials and energy. However, autophagy can also lead to a form of programmed cell death distinct from apoptosis. Components of the autophagic pathway are constitutively expressed at a high level in the eye, including in the cornea, lens, retina, and orbit...
2016: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/27835611/effect-of-cobalt-mediated-toll-like-receptor-4-activation-on-inflammatory-responses-in-endothelial-cells
#11
Sami A Anjum, Helen Lawrence, James P Holland, John A Kirby, David J Deehan, Alison J Tyson-Capper
Cobalt-containing metal-on-metal hip replacements are associated with adverse reactions to metal debris (ARMD), including inflammatory pseudotumours, osteolysis, and aseptic implant loosening. The exact cellular and molecular mechanisms leading to these responses are unknown. Cobaltions (Co2+) activate human Toll-like receptor 4 (TLR4), an innate immune receptor responsible for inflammatory responses to Gram negative bacterial lipopolysaccharide (LPS).We investigated the effect of Co2+-mediated TLR4 activation on human microvascular endothelial cells (HMEC-1), focusing on the secretion of key inflammatory cytokines and expression of adhesion molecules...
November 9, 2016: Oncotarget
https://www.readbyqxmd.com/read/27829734/601-metal-on-metal-total-hip-replacements-with-36%C3%A2-mm-heads-a-5-minimum-year-follow-up-levels-of-armd-remain-low-despite-a-comprehensive-screening-program
#12
Amit Atrey, Alister Hart, Nasir Hussain, Jonathon Waite, Andrew J Shepherd, Steve Young
BACKGROUND: We conducted a retrospective study to assess the clinical outcome, failure rate, and reason for failure of a large consecutive series of 36 mm MoM Corail/Pinnacle total hip replacements (THRs). METHODS: Between 2006 and 2011, 601 consecutive 36 mm MoM THRs were performed (585 patients). Patients were followed according to the UK Medicines and Healthcare Products Regulatory Agency (MHRA) guidelines. All patients were accounted for and 469 patients (78%) were clinically and radiographically assessed...
March 2017: Journal of Orthopaedics
https://www.readbyqxmd.com/read/27803220/can-blood-metal-ion-levels-be-used-to-identify-patients-with-bilateral-birmingham-hip-resurfacings-who-are-at-risk-of-adverse-reactions-to-metal-debris
#13
G S Matharu, F Berryman, L Brash, P B Pynsent, D J Dunlop, R B C Treacy
AIMS: We investigated whether blood metal ion levels could effectively identify patients with bilateral Birmingham Hip Resurfacing (BHR) implants who have adverse reactions to metal debris (ARMD). PATIENTS AND METHODS: Metal ion levels in whole blood were measured in 185 patients with bilateral BHRs. Patients were divided into those with ARMD who either had undergone a revision for ARMD or had ARMD on imaging (n = 30), and those without ARMD (n = 155). Receiver operating characteristic analysis was used to determine the optimal thresholds of blood metal ion levels for identifying patients with ARMD...
November 2016: Bone & Joint Journal
https://www.readbyqxmd.com/read/27759474/poor-10-year-survivorship-of-hip-resurfacing-arthroplasty
#14
MULTICENTER STUDY
Matti Seppänen, Mikko Karvonen, Petri Virolainen, Ville Remes, Pekka Pulkkinen, Antti Eskelinen, Antti Liukas, Keijo T Mäkelä
Background and purpose - In a previous registry report, short-term implant survival of hip resurfacing arthroplasty (HRA) in Finland was found to be comparable to that of total hip arthroplasty (THA). Since then, it has become evident that adverse reactions to metal debris (ARMDs) may also be associated with HRA, not only with large-diameter head metal-on-metal THA. The aim of the study was to assess medium- to long-term survivorship of HRA based on the Finnish Arthroplasty Register (FAR). Patients and methods - 5,068 HRAs performed during the period 2001-2013 in Finland were included...
December 2016: Acta Orthopaedica
https://www.readbyqxmd.com/read/27748300/homocysteine-its-metabolite-homocysteine-thiolactone-deficiency-of-copper-in-patients-with-age-related-macular-degeneration-a-pilot-study
#15
Muthuvel Bharathselvi, Sayantan Biswas, Rajiv Raman, Radhakrishnan Selvi, Karunakaran Coral, Angayarkanni Narayanansamy, Sivaramakrishnan Ramakrishnan, Konerirajapuram N Sulochana
BACKGROUND & OBJECTIVES: Age related macular degeneration (ARMD) is a leading cause of blindness, particularly in persons above 60 yr of age. Homocysteine is implicated in many ocular diseases including ARMD. This study was undertaken to assess the status and relationship between plasma homocysteine, homocysteine - thiolactone, homocysteinylated protein and copper levels in patients with ARMD. METHODS: A total of 16 patients with ARMD and 16 age-matched controls were recruited for the study...
June 2016: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/27729758/the-relationship-between-neutrophil-to-lymphocyte-ratio-and-age-related-macular-degeneration
#16
Bengi Ece Kurtul, Pinar Altiaylik Ozer
PURPOSE: To investigate the possible associations of neutrophil-to-lymphocyte ratio (NLR) and high sensitivity C-reactive protein (hs-CRP) level with age-related macular degeneration (ARMD). METHODS: Patients were divided to three groups of 40 patients with non-neovascular ARMD (group 1), 40 patients with neovascular ARMD (group 2), and 40 healthy control subjects (group 3). The neutrophil and lymphocyte counts were evaluated using an ABX Pentra DF120/USA biochemical analyzer, and hs-CRP levels were measured using a Beckman Coulter Immage 800...
October 2016: Korean Journal of Ophthalmology: KJO
https://www.readbyqxmd.com/read/27704611/variation-in-taper-surface-roughness-for-a-single-design-effects-the-wear-rate-in-total-hip-arthroplasty
#17
Robert K Whittaker, Harry S Hothi, Antti Eskelinen, Gordon W Blunn, John A Skinner, Alister J Hart
Material loss from the head-stem taper junction of total hip arthroplasty (THA) is implicated in adverse reactions to metal debris (ARMD); the mechanisms for this are multi-factorial. We investigated the relationship between the roughness of the "as manufactured" taper surface and the wear rate from this junction. Fifty retrieved Pinnacle metal-on-metal (MOM) bearings paired with a Corail stem were included in the study. Multivariable statistical analysis was performed to determine the influence of taper roughness on material loss rate after controlling for other confounding surgical, implant, and patient factors...
October 5, 2016: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/27612918/blood-metal-ion-levels-are-not-a-useful-test-for-adverse-reactions-to-metal-debris-a-systematic-review-and-meta-analysis
#18
M Pahuta, J M Smolders, J L van Susante, J Peck, P R Kim, P E Beaule
OBJECTIVES: Alarm over the reported high failure rates for metal-on-metal (MoM) hip implants as well as their potential for locally aggressive Adverse Reactions to Metal Debris (ARMDs) has prompted government agencies, internationally, to recommend the monitoring of patients with MoM hip implants. Some have advised that a blood ion level >7 µg/L indicates potential for ARMDs. We report a systematic review and meta-analysis of the performance of metal ion testing for ARMDs. METHODS: We searched MEDLINE and EMBASE to identify articles from which it was possible to reconstruct a 2 × 2 table...
September 2016: Bone & Joint Research
https://www.readbyqxmd.com/read/27580527/failure-rates-of-asian-type-anatomic-medullary-locking-stemmed-metal-on-metal-total-hip-replacement-a-cause-for-adverse-tissue-reactions-to-metal-debris-armd
#19
Masaru Nakamura, Tateaki Shimakawa, Shunji Nakano, Takashi Chikawa, Shinji Yoshioka, Masahiro Kashima, Shunichi Toki, Hidehisa Horiguchi, Koichi Sairyo
BACKGROUND: Adverse tissue reaction to metal debris (ARMD) as a secondary complication of Metal-on-metal total hip replacement (MoM THR) has been of concern. We have been performing cementless MoM THR using an Asian-type anatomic medullary locking (AML) stem. The purpose of this study is to examine the incident rate of ARMD, and the implant survival rate. METHODS: The study included 187 patients (211 hip joints) who underwent MoM THR between February 2007 and November 2009 at our hospital and who were followed up for a minimum of 6 years...
November 2016: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/27498633/empirical-force-fields-for-mechanistic-studies-of-chemical-reactions-in-proteins
#20
A K Das, M Meuwly
Following chemical reactions in atomistic detail is one of the most challenging aspects of current computational approaches to chemistry. In this chapter the application of adiabatic reactive MD (ARMD) and its multistate version (MS-ARMD) are discussed. Both methods allow to study bond-breaking and bond-forming processes in chemical and biological processes. Particular emphasis is put on practical aspects for applying the methods to investigate the dynamics of chemical reactions. The chapter closes with an outlook of possible generalizations of the methods discussed...
2016: Methods in Enzymology
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