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Xin-Xin Wen, Hai-Long Yu, Ya-Bo Yan, Chun-Lin Zong, Hai-Jiao Ding, Xiang-Yu Ma, Tian-Sheng Wang, Wei Lei
Assessing the biomechanical properties of trabecular bone is of major biological and clinical significance for the research of bone diseases, fractures and their treatments. Micro-finite element (µFE) models are becoming increasingly popular for investigating the biomechanical properties of trabecular bone. The shapes of µFE models typically include cube and cylinder. Whether there are differences between cubic and cylindrical µFE models has not yet been studied. In the present study, cubic and cylindrical µFE models of human vertebral trabecular bone were constructed...
August 2017: Experimental and Therapeutic Medicine
Ding-Sheng Jiang, Xin Yi, Rui Li, Yun-Shu Su, Jing Wang, Min-Lai Chen, Li-Gang Liu, Min Hu, Cai Cheng, Ping Zheng, Xue-Hai Zhu, Xiang Wei
Histone modifications play a critical role in the pathological processes of dilated cardiomyopathy (DCM). While the role and expression pattern of histone methyltransferases (HMTs), especially mixed lineage leukemia (MLL) families on DCM are unclear. To this end, twelve normal and fifteen DCM heart samples were included in the present study. A murine cardiac remodelling model was induced by transverse aortic constriction (TAC). Real-time PCR was performed to detect the expression levels of MLL families in the mouse and human left ventricles...
August 9, 2017: Molecular Medicine
Yuan Liu, Sheng Tan, Hao Zhang, Xiangjun Kong, Lili Ding, Jie Shen, Yan Lan, Cheng Cheng, Tao Zhu, Weidong Xia
Non-thermal atmospheric plasma (NTP) has shown its selective anticancer effects in many types of tumors in vitro and one of the main mechanisms is that the different increase of intracellular ROS in cancer and homologous normal cells. In this study, we report that NTP treatment reduces the proliferation in triple negative breast cancer (TNBC) and normal cell lines. Simultaneously, STAT3 pathway is inhibited by NTP effects. However, it is observed that normal cells MCF10A are more sensitive to ROS toxicity induced by NTP than cancer cells MDA-MB-231...
August 11, 2017: Scientific Reports
Yunlu Sheng, Shan Lv, Min Huang, Yifan Lv, Jing Yu, Juan Liu, Tingting Tang, Hanmei Qi, Wenjuan Di, Guoxian Ding
Calorie restriction (CR) increases average and maximum lifespan and exhibits an apparent beneficial impact on age-related diseases. Several studies have shown that CR initiated either in middle or old age could improve ischemic tolerance and rejuvenate the aging heart; however, the data are not uniform when initiated in young. The accurate time to initiate CR providing maximum benefits for cardiac remodeling and function during aging remains unclear. Thus, whether a similar degree of CR initiated in mice of different ages could exert a similar effect on myocardial protection was investigated in this study...
August 11, 2017: Aging Cell
Di Lu, Wei-Guo Ding, Hong-Feng Sheng, Xin-Wei Xu, Ying-Xiao Zhang, Weixing Xu
OBJECTIVE: The purpose of this systematic review and meta-analysis of randomized controlled trials (RCTs) and non-RCTs was to evaluate the effect of using a bipolar sealer to prevent surgical bleeding in spine surgery. METHODS: In June 2017, the PubMed, Embase, Cochrane controlled trials register, Web of Science, Google, and Chinese Wanfang databases were used to identify RCTs and non-RCTs comparing the effects of intraoperative placement of a bipolar sealer versus standard electrocautery with regard to blood loss and blood transfusion...
August 7, 2017: International Journal of Surgery
Jing Zhao, Yang Li, Junlu Sheng, Xianfeng Wang, Lifang Liu, Jianyong Yu, Bin Ding
Waterproof and breathable membranes which provide high level of protection and comfort are promising core materials to meet the pressing demand for future upscale protective clothing. However, creating such materials characterized with environmental protection, high performance and ease of fabrication has proven to be a great challenge. Herein, we report a novel strategy to synthesize fluorinated polyurethane (C6FPU) containing short perfluorohexyl (-C6F13) chains, and introduced it as hydrophobic agent into polyurethane (PU) solution for one-step electrospinning...
August 10, 2017: ACS Applied Materials & Interfaces
Geng Zhang, Ping Wang, Wang-Ting Lu, Cao-Yu Wang, Yong-Ke Li, Cong Ding, Jiangjiang Gu, Xin-Sheng Zheng, Fei-Fei Cao
The development of high-performance electrocatalyst with earth-abundant elements for water-splitting is a key factor to improve its cost efficiency. Here, a noble metal free bi-functional electrocatalyst was synthesized by a facile pyrolysis method using sucrose, urea, Co(NO3)2 and sulfur powder as raw materials. During the fabrication process, Co, S co-doped graphitic carbon nitride (g-C3N4) was firstly produced, and then this in-situ formed template further induced the generation of a Co, N, S tri-doped graphene coupled with Co nanoparticles...
August 10, 2017: ACS Applied Materials & Interfaces
Tao Xu, Kelly M Stewart, Xiaohu Wang, Kai Liu, Min Xie, Jae Kyu Ryu, Ke Li, Tianhua Ma, Haixia Wang, Lu Ni, Saiyong Zhu, Nan Cao, Dongwei Zhu, Yu Zhang, Katerina Akassoglou, Chen Dong, Edward M Driggers, Sheng Ding
Metabolism has been shown to integrate with epigenetics and transcription to modulate cell fate and function. Beyond meeting the bioenergetic and biosynthetic demands of T-cell differentiation, whether metabolism might control T-cell fate by an epigenetic mechanism is unclear. Here, through the discovery and mechanistic characterization of a small molecule, (aminooxy)acetic acid, that reprograms the differentiation of T helper 17 (TH17) cells towards induced regulatory T (iTreg) cells, we show that increased transamination, mainly catalysed by GOT1, leads to increased levels of 2-hydroxyglutarate in differentiating TH17 cells...
August 2, 2017: Nature
Ying-Fei Li, Jian-Wu Ding, Ling-Min Liao, Zhi-Lin Zhang, Shou-Sheng Liao, Ying Wu, Dan-Yang Zhou, An-Wen Liu, Long Huang
Programmed death ligand-1 (PD-L1) is a potentially important tumor immunotherapy target. However, whether PD-L1 expression is associated with survival in nasopharyngeal carcinoma (NPC) remains controversial. The aim of the present study was to investigate the association between PD-L1 expression and prognosis in NPC. The expression of PD-L1 was assessed in tumor specimens from 120 patients with NPC using immunohistochemistry. Staining was evaluated using the H-score method. The associations between PD-L1 expression and clinical characteristics and prognosis were analyzed...
September 2017: Molecular and Clinical Oncology
L Wang, Y X Fan, Y Ding, Q J Sheng, C Zhang, L R Zhao, T T Xia, Z Y An, H Bai, H Y Shi, X G Dou
Objective: To explore the difference of liver inflammation and fibrosis in patients with chronic hepatitis B virus (HBV) infection and chronic hepatitis C virus (HCV) infection, and to investigate the relationship between hepatic pathology and alanine aminotransferase (ALT). Methods: 57 patients with chronic HCV infection and 346 patients with chronic HBV infection who were hospitalized at Shengjing Hospital of China Medical University from January 2012 to September 2016 were enrolled. In chronic HBV infection, including 88 cases whose ALT were more than two times of upper limited of normal (ALT≥2×ULN) and 258 cases whose ALT were less than two times of upper limited of normal (ALT < 2×ULN)...
June 20, 2017: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
Ya-Hui Ding, Yuan Ma, Lin-Yan Qian, Qiang Xu, Li-Hong Wang, Dong-Sheng Huang, Hai Zou
Non-alcoholic fatty liver disease (NAFLD) and atrial fibrillation (AF) are common chronic non-infectious diseases with rising incidences. NAFLD is an independent risk factor for the onset of AF, after adjusting potentially related factors. The pathogenesis of these diseases share several mechanisms including reduced adiponectin level, insulin resistance, and renin angiotensin aldosterone system (RAAS) activation, in addition to activation of common disease pathways that promote inflammation, oxidative stress, and fibrosis...
July 24, 2017: Oncotarget
Lin-Sen Qing, Shu-Lin Peng, Jian Liang, Li-Sheng Ding
There is an urgent need for a water-soluble derivative of astragaloside IV for drug R&D. In the present study, a remarkably simple method for the preparation of such a water-soluble derivative of astragaloside IV has been developed. This protocol involves oxidative 2,2,6,6-tetramethylpiperidine-1-oxyl free radical (TEMPO)-mediated transformation of astragaloside IV to its carboxylic acid derivative, which is a new compound named astragalosidic acid. The structure of astragalosidic acid was elucidated by means of spectroscopic analysis...
July 31, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Ai Min Yang, Zhi Yuan Cheng, Hong Quan Pu, Ning Cheng, Hai Yan Li, Si Min Liu, Jiao Ding, Juan Sheng Li, Xiao Bin Hu, Xiao Wei Ren, Tong Zhang Zheng, Ya Na Bai
Environmental exposure to heavy metals has been linked to a wide range of human health hazards. We detected the levels of 15 metals in urine samples from 500 representative sub-samples in an ongoing occupational cohort study (Jinchang Cohort) to directly evaluate metal exposure levels. Fifteen metals, namely As, Ba, Be, Cd, Cs, Cr, Co, Cu, Pb, Mn, Ni, Se, Tl, U, and Zn, were detected by inductively coupled plasma quadruple mass spectrometry. The results showed that median creatinine adjustment and geometric mean urinary metal levels were higher in the heavy metal-exposed group, except Se and Zn, than other reported general or occupational populations...
July 2017: Biomedical and Environmental Sciences: BES
Nalini Yasoda Hirimuthugoda, Adeniyi C Adeola, Patthamesthrige Wimal Anthony Perera, Xing Chen, Weligalle Wedarallage Dewar Asoka Gunawardena, Humpita Gamaralalage Thilini Nisanka Gunawardana, Ting-Ting Yin, Ming-Shan Wang, Gui-Mei Li, Zhao-Li Ding, Wen-Zhi Wang, Hai-Bing Xie, Min-Sheng Peng, Ya-Ping Zhang
No abstract text is available yet for this article.
July 27, 2017: Animal Genetics
Jiwei Zhang, Zhe Li, Longzi Liu, Qifeng Wang, Shengli Li, Di Chen, Zhixiang Hu, Tao Yu, Jie Ding, Jinjun Li, Ming Yao, Shenglin Huang, Yingjun Zhao, Xianghuo He
Long noncoding RNAs (lncRNAs) can serve as oncogenes or tumor suppressors in human cancer; however, their biological functions and underlying mechanism in hepatocarcinogenesis are largely unknown. Here, we report a novel tumor suppressor lncRNA on chromosome 8p12 (termed TSLNC8) that is frequently deleted and downregulated in hepatocellular carcinoma (HCC) tissues. The loss of TSLNC8 is highly associated with the malignant features of HCC and serves as a prognostic indicator for HCC patients. TSLNC8 significantly suppresses the proliferation and metastasis of HCC cells in vitro and in vivo...
July 26, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
Chih-Chieh Tseng, Ming-Tang Lai, Chia-Che Wu, Sheng-Po Yuan, Yi-Fang Ding
OBJECTIVE: Since the 1950s, microscopic myringoplasty has been the standard surgery for repairing a perforated tympanic membrane. In addition to conventional microscopic myringoplasty, endoscopic myringoplasty has been an emerging technique since the late 1990s. This study evaluated the efficacy of endoscopic transcanal myringoplasty for repairing tympanic perforations and examined the minimally invasive feature of this technique (no postauricular incision, no canalplasty). METHODS: We retrospectively reviewed the medical records of patients who underwent endoscopic transcanal myringoplasty for perforations of the tympanic membrane...
July 21, 2017: Auris, Nasus, Larynx
Yi-Ming Zhong, Rui Yuan, Jian-Sheng Ding, Fang Yang, Wen-En Liu
OBJECTIVE: To investigate the staphylococcal cassette chromosome mec (SCCmec) genotype and molecular epidemiological characteristics of healthcare-associated methicillin-resistant Staphylococcus aureus (HA-MRSA) in a large teaching hospital in China. METHDOS: From January 2012 to December 2012, a total of 71 nonduplicate HA-MRSA were collected in a teaching hospital in Changsha, China. SCCmec types were determined by multiplex PCR, and Panton-Valentine leukocidin (PVL) gene was detected by PCR...
July 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
Wei-Xia Dong, Jin-Li Ding, Yang Gao, Yue-Jin Peng, Ming-Guang Feng, Sheng-Hua Ying
Alternative splicing (AS) regulates various biological processes in fungi by extending the cellular proteome. However, comprehensive studies investigating AS in entomopathogenic fungi are lacking. Based on transcriptome data obtained via dual RNA-seq, the first overview of AS events was developed for Beauveria bassiana growing in an insect hemocoel. The AS was demonstrated for 556 of 8,840 expressed genes, accounting for 5.4% of the total genes in B. bassiana. Intron retention was the most abundant type of AS, accounting for 87...
July 21, 2017: Environmental Microbiology
Liang Wu, Jinglong Liu, Hui Li, Chunfeng Ding, Ningning Xu, Xiaolei Zhao, Zongcheng Xu, Quan Sheng, Jianquan Yao, Jining Li, Xin Ding, Weili Zhang
The dielectric properties of an active KTaO3 hybrid metamaterial structure and its tunability under external electric fields are investigated at room temperature by means of terahertz time-domain spectroscopy. Application of the electric field leads to an appreciable tuning of the dielectric loss, which is up to 17%. Meanwhile, the refractive index also changes appreciably. These findings are attributed to the internal space charge field in the crystal caused by the excited free carriers.
July 20, 2017: Scientific Reports
Chenchen Dai, Yingli Cao, Yan Jia, Yuqin Ding, Ruofan Sheng, Mengsu Zeng, Jianjun Zhou
PURPOSE: To investigate the possibility of iodine quantification during a single nephrographic phase in characterizing renal cell carcinoma (RCC) subtypes and if there is a difference between areal and volumetric iodine quantification methods. MATERIALS AND METHODS: This retrospective study included 110 patients with 113 histopathologically confirmed RCCs scanned by dual-energy CT at the nephrographic phase before surgeries. For each lesion, an areal measurement of the iodine concentration with maximum enhancement (I max enhan) and the iodine concentration with maximum area among slices (I max area), as well as a volumetric iodine concentration of the whole-tumor (I volume), were evaluated by two independent radiologists...
July 18, 2017: Abdominal Radiology
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