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https://www.readbyqxmd.com/read/29338437/elderly-population-have-a-decreased-aneurysmal-subarachnoid-hemorrhage-incidence-rate-than-middle-aged-population-a-descriptive-analysis-of-8-144-cases-in-mainland-china
#1
Yì Xiáng J Wáng, Lihong Zhang, Lin Zhao, Jian He, Xian-Jun Zeng, Heng Liu, Yun-Jun Yang, Shang-Wei Ding, Zhong-Fei Xu, Yong-Ming He, Lin Yang, Lan Sun, Ke-Jie Mu, Bai-Song Wang, Xiao-Hong Xu, Zhong-You Ji, Jian-Hua Liu, Jin-Zhou Fang, Rui Hou, Feng Fan, Guang-Ming Peng, Yue-Qi Zhu, Sheng-Hong Ju, Wai S Poon
PURPOSE: Rupture of an intracranial aneurysm is a life-threatening acute cerebrovascular event. The purpose of this study was to investigate whether aneurysmal subarachnoid haemorrhage (SAH) incidence rate is higher or lower in elderly population than in middle aged population. MATERIALS AND METHODS: Aneurysmal SAH cases were collected retrospectively from the archives of 21 hospitals in Mainland China. All the cases were collected from September 2016 and backward consecutively for a period of time up to 8 years...
January 17, 2018: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/29338218/mimicking-the-key-functions-of-photosystem-ii-in-artificial-photosynthesis-for-photoelectrocatalytic-water-splitting
#2
Sheng Ye, Chunmei Ding, Ruotian Chen, Fengtao Fan, Ping Fu, Heng Yin, Xiuli Wang, Zhiliang Wang, Pingwu Du, Can Li
It has been anticipated that learning from nature photosynthesis is a rational and effective way to develop artificial photosynthesis system, but it is still a great challenge. Here, we assembled a photoelectrocatalytic system by mimicking the functions of photosystem II (PSII), with BiVO4 semiconductor as a light-harvester protected by a layered double hydroxide (NiFeLDH) as a hole storage layer, a partially oxidized graphene (pGO) as biomimetic tyrosine for charge transfer, and molecular Co cubane as oxygen evolution complex...
January 17, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29335843/study-on-the-clinical-features-and-prognosis-of-penicilliosis-marneffei-without-human-immunodeficiency-virus-infection
#3
Ying-Ge Wang, Jin-Mei Cheng, Hai-Bo Ding, Xi Lin, Guo-Hao Chen, Mei Zhou, Sheng-Nan Ye
OBJECTIVE: To improve the diagnosis and treatment of Penicilliosis marneffei without human immunodeficiency virus infection. METHODS: Analyze and review the clinical features, diagnosis and treatment of six cases of P. marneffei without human immunodeficiency virus infection at The First Affiliated Hospital of Fujian Medical University. RESULTS: Two cases were diagnosed in the ENT Department, three cases in the respiratory department and one case in the dermatological department...
January 15, 2018: Mycopathologia
https://www.readbyqxmd.com/read/29335085/-impact-of-transition-readiness-on-quality-of-life-in-children-with-chronic-diseases
#4
Jia-Li Ma, Nan Sheng, Wen-Wen Ding, Ying Zhang
OBJECTIVE: To investigate the current quality of life in children with chronic diseases, and to explore the impact of transition readiness on quality of life. METHODS: A total of 332 children with chronic diseases from two children's hospitals in Shanghai, China were enrolled. A self-designed demographic questionnaire, Pediatric Quality of Life Inventory 4.0 Generic Core Scales (PedsQLTM 4.0), and Self-Management and Transition to Adulthood with Rx=Treatment (STARx) Questionnaire were used to evaluate transition readiness and quality of life...
January 2018: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/29333671/selective-enrichment-of-n-linked-glycopeptides-and-glycans-by-using-a-dextran-modified-hydrophilic-material
#5
Linlin Chen, Di Ding, Qianying Sheng, Long Yu, Xiuping Liu, Xinmiao Liang
Glycosylation analysis of proteins from biological sources utilizing mass-spectrometry-based approaches is challenging due to the relatively low abundance of glycopeptides, the structural diversity of glycans as well as the co-existing matrices. In this study, a customized dextran-bonded silica-based stationary phase was introduced for selective enrichment of glycopeptides and glycans from complex biological samples. This material has exhibited superior selectivity and broader glycosylation site coverage over commercial Sepharose in glycoproteomic evaluation...
January 15, 2018: Journal of Separation Science
https://www.readbyqxmd.com/read/29333103/interleukin-35-level-is-elevated-in-patients-with-chronic-hepatitis-b-virus-infection
#6
Sheng-Tao Cheng, Ding Yuan, Yi Liu, Ying Huang, Xiang Chen, Hai-Bo Yu, Lin He, Hui Jiang, Ji-Hua Ren, Juan Chen
Backgrounds: As one of the major public health problems, the hepatitis B virus (HBV) infection would activate the immune system. The outcome of HBV infection was affect significantly by the interactions between HBV and host immune response. Interleukins play important role in anti-viral immunity. Here we investigated the role of interleukin-35 (IL-35) in chronic HBV infection patients. Methods/Results: Serum IL-35 in 72 chronic hepatitis B virus infection patients and 41 healthy control subjects were analyzed by ELISA assay...
2018: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29331305/tigar-inhibits-ischemia-reperfusion-induced-inflammatory-response-of-astrocytes
#7
Jieyu Chen, Ding-Mei Zhang, Xing Feng, Jian Wang, Yuan-Yuan Qin, Tian Zhang, Qiao Huang, Rui Sheng, Zhong Chen, Mei Li, Zheng-Hong Qin
The inflammatory response of glial cells contributes to neuronal damage or repair after brain ischemia/reperfusion insult. We previously demonstrated a protective role of TP53-induced glycolysis and apoptosis regulator (TIGAR) in ischemic neuronal injury through increasing the flow of pentose phosphate pathway (PPP). The present study investigated the possible role of TIGAR in ischemia/reperfusion-induced inflammatory response of astrocytes. Male ICR mice were subjected to middle cerebral artery occlusion for 2 h followed by 24 h reperfusion and cultured primary astrocytes were subjected to oxygen glucose deprivation for 9 h followed by 24 h reoxygenation (OGD/R)...
January 10, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29321334/mechanism-of-hiv-1-resistance-to-an-electronically-constrained-%C3%AE-helical-peptide-membrane-fusion-inhibitor
#8
Xiyuan Wu, Zixuan Liu, Xiaohui Ding, Danwei Yu, Huamian Wei, Bo Qin, Yuanmei Zhu, Huihui Chong, Sheng Cui, Yuxian He
SC29EK is an electronically constrained α-helical peptide HIV-1 fusion inhibitor highly effective against both wild-type and enfuvirtide (T20)-resistant viruses. In this study, we focused on investigating the mechanism of HIV-1 resistance to SC29EK by two approaches. First, SC29EK-escaping HIV-1 variants were selected and characterized. Three mutant viruses, which possessed two (E43K/E49A) or three (Q39R/N43K/N126K, N43K/E49A/N126K) amino acid substitutions in the N- and C-terminal repeat regions of gp41 were identified as conferring high resistance to SC29EK and cross-resistance to the first-generation (T20, C34) and newly-designed (sifuvirtide, MT-SC29EK, 2P23) fusion inhibitors...
January 10, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29304864/hypercapnia-induces-il-1%C3%AE-overproduction-via-activation-of-nlrp3-inflammasome-implication-in-cognitive-impairment-in-hypoxemic-adult-rats
#9
Hong-Guang Ding, Yi-Yu Deng, Ren-Qiang Yang, Qiao-Sheng Wang, Wen-Qiang Jiang, Yong-Li Han, Lin-Qiang Huang, Miao-Yun Wen, Wen-Hong Zhong, Xu-Sheng Li, Fan Yang, Hong-Ke Zeng
BACKGROUND: Cognitive impairment is one of common complications of acute respiratory distress syndrome (ARDS). Increasing evidence suggests that interleukin-1 beta (IL-1β) plays a role in inducing neuronal apoptosis in cognitive dysfunction. The lung protective ventilatory strategies, which serve to reduce pulmonary morbidity for ARDS patients, almost always lead to hypercapnia. Some studies have reported that hypercapnia contributes to the risk of cognitive impairment and IL-1β secretion outside the central nervous system (CNS)...
January 5, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29299204/downregulation-of-microrna-125a-is-involved-in-intervertebral-disc-degeneration-by-targeting-pro-apoptotic-bcl-2-antagonist-killer-1
#10
Ping Liu, Feng Chang, Ting Zhang, Gang Gao, Chen Yu, Sheng-Qiang Ding, Gen-Le Zuo, Xin-Hu Huang
Objectives: To investigate the role of the microRNA-125a (miR-125a) and BAK1 in intervertebral disc degeneration (IDD). Materials and Methods: Degenerative lumbar nucleus pulposus (NP) tissues were obtained from 193 patients who underwent resection, and normal controls consisted of normal NP tissues from 32 patients with traumatic lumbar fracture in our hospital. All patients were graded according to the Pfirrmann criteria. QRT-PCR was used to detect the expression of miR-125a and BAK1, and apoptosis of NP tissues detected by TUNEL staining...
November 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29290972/survival-benefits-of-gastrectomy-in-gastric-cancer-patients-with-stage-iv-a-population-based-study
#11
Xingkang He, Sanchuan Lai, Tingting Su, Yangyang Liu, Yue Ding, Sheng Quan, Jianmin Si, Leimin Sun
Objective: The aim of the current study is to investigate the role of gastrectomy for survival among metastatic gastric cancer patients. Results: We finally identified 12,986 eligible patients with stage IV GC between 2004 and 2012, including 1,981 (15.3%) patients with gastrectomy and 11,005 (84.7%) without surgery. The median overall survival time for patients with and without surgery were 9.0 (95%, 8.3-9.7) and 4.0 (95%, 3.9-4.1) months respectively. Patients who received gastrectomy had a significantly better survival outcome compared with those without surgery (P < 0...
December 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/29287705/cost-effectiveness-analysis-of-endoscopic-tympanoplasty-versus-microscopic-tympanoplasty-for-chronic-otitis-media-in-taiwan
#12
Chih-Chieh Tseng, Ming-Tang Lai, Chia-Che Wu, Sheng-Po Yuan, Yi-Fang Ding
BACKGROUND: Health care systems and physicians need to conform to budgets and streamline resources to provide cost-effective quality care. Although endoscopic tympanoplasty (ET) has been performed for decades, no studies on the cost-effectiveness of ET and microscopic tympanoplasty (MT) for treating chronic otitis media have been published. The present study aimed to compare the cost-effectiveness of ET and MT for treating chronic otitis media. METHODS: This study was performed using a Cohort-style Markov decision-tree economic model with a 30-year time horizon...
December 26, 2017: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/29283249/live-cell-visualization-of-multiple-protein-protein-interactions-with-bifc-rainbow
#13
Sheng Wang, Miao Ding, Boxin Xue, Yingping Hou, Yujie Sun
As one of the most powerful tools to visualize PPIs in living cells, bimolecular fluorescence complementation (BiFC) has gained great advancement during the recent years, including deep tissue imaging with far-red or near-infrared fluorescent proteins or super-resolution imaging with photochromic fluorescent proteins. However, little progress has been made towards simultaneous detection and visualization of multiple PPIs in the same cell, mainly due to the spectral crosstalk. In this report, we developed novel BiFC assays based on large-Stokes-shift fluorescent proteins (LSS-FPs) to detect and visualize multiple PPIs in living cells...
December 28, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/29282023/is-meat-consumption-associated-with-depression-a-meta-analysis-of-observational-studies
#14
Yi Zhang, Ye Yang, Ming-Sheng Xie, Xiang Ding, Hui Li, Zhi-Chen Liu, Shi-Fang Peng
BACKGROUND: A number of epidemiological studies have examined the effect of meat consumption on depression. However, no conclusion has been reached. The aim of this study was to examine the relationship between meat consumption and depression. METHODS: The electronic databases of PUBMED and EMBASE were searched up to March 2017, for observational studies that examined the relationship between meat consumption and depression. The pooled odds ratio (OR) for the prevalence of depression and the relative risk (RR) for the incidence of depression, as well as their corresponding 95% confidence interval (CI), were calculated respectively (the highest versus the lowest category of meat consumption)...
December 28, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/29280351/mir-27b-3p-regulation-in-browning-of-human-visceral-adipose-related-to-central-obesity
#15
Jing Yu, Yifan Lv, Wenjuan Di, Juan Liu, Xiaocen Kong, Yunlu Sheng, Min Huang, Shan Lv, Hanmei Qi, Mei Gao, Hui Liang, Sarah Kim, Zan Fu, Hong Zhou, Guoxian Ding
OBJECTIVE: Given the rising prevalence of central obesity and the discovery that beige cells appear within white adipose tissue, strategies to enhance these energy-expending adipocytes or "browning" within white adipose depots have become of therapeutic interest to combat obesity and its associated disorders. This study focused on, the role of microRNA (miRNA)-27b-3p in human visceral adipose tissue (VAT) browning. METHODS: Expression of miR-27b-3p and UCP1 in VAT and serum of humans was measured...
December 27, 2017: Obesity
https://www.readbyqxmd.com/read/29278390/aerobic-biodegradation-characteristic-of-different-water-soluble-azo-dyes
#16
Shixiong Sheng, Bo Liu, Xiangyu Hou, Bing Wu, Fang Yao, Xinchun Ding, Lin Huang
This study investigated the biodegradation performance and characteristics of Sudan I and Acid Orange 7 (AO7) to improve the biological dye removal efficiency in wastewater and optimize the treatment process. The dyes with different water-solubility and similar molecular structure were biologically treated under aerobic condition in parallel continuous-flow mixed stirred reactors. The biophase analysis using microscopic examination suggested that the removal process of the two azo dyes is different. Removal of Sudan I was through biosorption, since it easily assembled and adsorbed on the surface of zoogloea due to its insolubility, while AO7 was biodegraded incompletely and bioconverted, the AO7 molecule was decomposed to benzene series and inorganic ions, since it could reach the interior area of zoogloea due to the low oxidation-reduction potential conditions and corresponding anaerobic microorganisms...
December 26, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29277274/maternal-high-estradiol-exposure-alters-cdkn1c-and-igf2-expression-in-human-placenta
#17
Xi-Jing Chen, Feng Chen, Ping-Ping Lv, Dan Zhang, Guo-Lian Ding, Xiao-Ling Hu, Chun Feng, Jian-Zhong Sheng, He-Feng Huang
INTRODUCTION: The increased maternal estradiol (E2) concentrations induced by assisted reproductive technology (ART) result in lower birth weight of offspring, which is associated with increased risk of adult diseases. However, the exact mechanism remains unknown. The present study investigated the effect of high E2 exposure on the expression of imprinted genes CDKN1C and IGF2 in human placentas and the DNA methylation status of their differential methylation regions (DMRs). METHODS: The mRNA expression of CDKN1C and IGF2 in human placentas and the human trophoblast cells (HTR8) treated with E2 were investigated by reverse transcription-real time polymerase chain reaction (PCR)...
January 2018: Placenta
https://www.readbyqxmd.com/read/29259373/mesenchymal-stem-cells-rescue-acute-hepatic-failure-by-polarizing-m2-macrophages
#18
Yan-Wei Li, Chong Zhang, Qiu-Ju Sheng, Han Bai, Yang Ding, Xiao-Guang Dou
AIM: To investigate whether M1 or M2 polarization contributes to the therapeutic effects of mesenchymal stem cells (MSCs) in acute hepatic failure (AHF). METHODS: MSCs were transfused into rats with AHF induced by D-galactosamine (DGalN). The therapeutic effects of MSCs were evaluated based on survival rate and hepatocyte proliferation and apoptosis. Hepatocyte regeneration capacity was evaluated by the expression of the hepatic progenitor surface marker epithelial cell adhesion molecule (EpCAM)...
December 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29247195/prevalence-of-metabolic-syndrome-and-its-associated-factors-among-multi-ethnic-adults-in-rural-areas-in-xinjiang-china
#19
Heng Guo, Xiang Gao, Rulin Ma, Jiaming Liu, Yusong Ding, Mei Zhang, Jingyu Zhang, Lati Mu, Jia He, Yizhong Yan, Jiaolong Ma, Shuxia Guo, Sheng Wei
Metabolic syndrome (MetS) has become a global public health problem affecting all nations and races. Few studies on the epidemic of metabolic syndrome (MetS) examined multi-ethnic adults in rural areas in Xinjiang, China. We thus investigated the prevalence and risk factors of MetS there. A cross-sectional study was performed in a representative sample of 15020 rural multi-ethnic adults from 2009 to 2010. Four widely used criteria (ATPIII\IDF\JIS\CDS) were used to measure the prevalence of MetS. Multiple logistic regression analysis was used to explore the risk factors of MetS...
December 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29243095/ca2-camkk%C3%AE-pathway-is-required-for-adiponectin-induced-secretion-in-rat-submandibular-gland
#20
Chong Ding, Zhi-Hao Du, Sheng-Lin Li, Li-Ling Wu, Guang-Yan Yu
Adiponectin functions as a promoter of saliva secretion in rat submandibular gland via activation of adenosine monophosphate-activated protein kinase (AMPK) and increased paracellular permeability. Ca2+ mobilization is the primary signal for fluid secretion in salivary acinar cells. However, whether intracellular Ca2+ mobilization is involved in adiponectin-induced salivary secretion is unknown. Here, we found that full-length adiponectin (fAd) increased intracellular Ca2+ and saliva secretion in submandibular glands...
December 14, 2017: Journal of Molecular Histology
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