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https://www.readbyqxmd.com/read/29150489/cumulative-burden-of-inflammation-predicts-colorectal-neoplasia-risk-in-ulcerative-colitis-a-large-single-centre-study
#1
Chang-Ho Ryan Choi, Ibrahim Al Bakir, Nik-Sheng John Ding, Gui-Han Lee, Alan Askari, Janindra Warusavitarne, Morgan Moorghen, Adam Humphries, Ana Ignjatovic-Wilson, Siwan Thomas-Gibson, Brian P Saunders, Matthew D Rutter, Trevor A Graham, Ailsa L Hart
OBJECTIVE: Ulcerative colitis (UC) is a dynamic disease with its severity continuously changing over time. We hypothesised that the risk of colorectal neoplasia (CRN) in UC closely follows an actuarial accumulative inflammatory burden, which is inadequately represented by current risk stratification strategies. DESIGN: This was a retrospective single-centre study. Patients with extensive UC who were under colonoscopic surveillance between 2003 and 2012 were studied...
November 17, 2017: Gut
https://www.readbyqxmd.com/read/29149157/full-endoscopic-procedures-versus-traditional-discectomy-surgery-for-discectomy-a-systematic-review-and-meta-analysis-of-current-global-clinical-trials
#2
Jun-Song Yang, Yong-Sheng Zeng, Tuan-Jiang Liu, Ding-Jun Hao
No abstract text is available yet for this article.
November 2017: Pain Physician
https://www.readbyqxmd.com/read/29148976/small-molecule-photoregulin3-prevents-retinal-degeneration-in-the-rho-p23h-mouse-model-of-retinitis-pigmentosa
#3
Paul A Nakamura, Andy A Shimchuk, Shibing Tang, Zhizhi Wang, Kole DeGolier, Sheng Ding, Thomas A Reh
Regulation of rod gene expression has emerged as a potential therapeutic strategy to treat retinal degenerative diseases like retinitis pigmentosa (RP). We previously reported on a small molecule modulator of the rod transcription factor Nr2e3, Photoregulin1 (PR1), that regulates the expression of photoreceptor-specific genes. Although PR1 slows the progression of retinal degeneration in models of RP in vitro, in vivo analyses were not possible with PR1. We now report a structurally unrelated compound, Photoregulin3 (PR3) that also inhibits rod photoreceptor gene expression, potentially though Nr2e3 modulation...
November 17, 2017: ELife
https://www.readbyqxmd.com/read/29148541/integrated-genomic-analysis-identifies-deregulated-jak-stat-myc-biosynthesis-axis-in-aggressive-nk-cell-leukemia
#4
Liang Huang, Dan Liu, Na Wang, Shaoping Ling, Yuting Tang, Jun Wu, Lingtong Hao, Hui Luo, Xuelian Hu, Lingshuang Sheng, Lijun Zhu, Di Wang, Yi Luo, Zhen Shang, Min Xiao, Xia Mao, Kuangguo Zhou, Lihua Cao, Lili Dong, Xinchang Zheng, Pinpin Sui, Jianlin He, Shanlan Mo, Jin Yan, Qilin Ao, Lugui Qiu, Hongsheng Zhou, Qifa Liu, Hongyu Zhang, Jianyong Li, Jie Jin, Li Fu, Weili Zhao, Jieping Chen, Xin Du, Guoliang Qing, Hudan Liu, Xin Liu, Gang Huang, Ding Ma, Jianfeng Zhou, Qian-Fei Wang
Aggressive NK-cell leukemia (ANKL) is a rare form of NK cell neoplasm that is more prevalent among people from Asia and Central and South America. Patients usually die within days to months, even after receiving prompt therapeutic management. Here we performed the first comprehensive study of ANKL by integrating whole genome, transcriptome and targeted sequencing, cytokine array as well as functional assays. Mutations in the JAK-STAT pathway were identified in 48% (14/29) of ANKL patients, while the extracellular STAT3 stimulator IL10 was elevated by an average of 56-fold (P < 0...
November 17, 2017: Cell Research
https://www.readbyqxmd.com/read/29148050/the-pharmacokinetics-of-morphine-and-codeine-in-human-plasma-and-urine-after-oral-administration-of-qiangli-pipa-syrup
#5
Bin-Bin Guo, Yu-Qiao Zhang, Sheng-Feng Wang, Jin-Song Ding, Wen-Hu Zhou
Papaveris pericarpium, a natural source of morphine and codeine, is the principal active component in many antitussive traditional Chinese medicines. We herein report the first PK study of papaveris pericarpium in human plasma and urine following oral administration of single (15, 30, 60 mL) and multiple dose (15 mL) of Qiangli Pipa Syrup (MOR 0.1 mg/mL, COD 0.028 mg/mL) by monitoring morphine and codeine using a HPLC-MS/MS method. Their Tmax and t1/2 values are independent of dosages, while the AUC0-t linearly increased with higher dosages, indicating linear PK characteristics...
November 17, 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/29140344/experimental-realization-of-narrowband-four-photon-greenberger-horne-zeilinger-state-in-a-single-cold-atomic-ensemble
#6
Ming-Xin Dong, Wei Zhang, Zhi-Bo Hou, Yi-Chen Yu, Shuai Shi, Dong-Sheng Ding, Bao-Sen Shi
Multi-photon entangled states not only play a crucial role in research on quantum physics but also have many applications in quantum information fields such as quantum computation, quantum communication, and quantum metrology. To fully exploit the multi-photon entangled states, it is important to establish the interaction between entangled photons and matter, which requires that photons have narrow bandwidth. Here, we report on the experimental generation of a narrowband four-photon Greenberger-Horne-Zeilinger state with a fidelity of 64...
November 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/29136404/galectin-3-expression-is-prognostic-in-diffuse-type-gastric-adenocarcinoma-confers-aggressive-phenotype-and-can-be-targeted-by-yap1-bet-inhibitors
#7
Jaffer A Ajani, Jeannelyn S Estrella, Qiongrong Chen, Arlene M Correa, Lang Ma, Ailing W Scott, Jiankang Jin, Bin Liu, Min Xie, Kazuki Sudo, Hironori Shiozaki, Brian Badgwell, Brian Weston, Jeffrey H Lee, Manoop S Bhutani, Hisashi Onodera, Koyu Suzuki, Akihiro Suzuki, Sheng Ding, Wayne L Hofstetter, Randy L Johnson, Robert S Bresalier, Shumei Song
BACKGROUND: Overexpression of Galectin-3 (Gal-3), a β-galactoside binding protein, has been noted in many tumour types but its functional significance and clinical utility in gastric adenocarcinoma (GAC) are not well known. METHODS: We studied 184 GAC patients characterised by histologic grade, sub-phenotypes (diffuse vs intestinal), and ethnicity (Asians vs North Americans). Immunohistochemistry was performed to assess the expression of Gal-3 in human GACs and we correlated it to the clinical outcomes...
November 14, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/29131125/splanchnic-cerebral-oxygenation-ratio-decreases-during-enteral-feedings-in-anemic-preterm-infants-observations-under-near-infrared-spectroscopy
#8
Katherine Braski, Kimberlee Weaver-Lewis, Manndi Loertscher, Qian Ding, Xiaoming Sheng, Mariana Baserga
BACKGROUND: Anemia is common in premature infants. Due to risks with red blood cell transfusions, many anemic infants are not transfused. The implications of this pathophysiologic status, especially at times of increased metabolic demand (enteral feedings), is not well understood. Near-infrared spectroscopy (NIRS) allows for the noninvasive determination of regional oxygen saturations (rSO2) in tissues such as the brain and mesentery, giving insight into their oxygen sufficiency. OBJECTIVE: We tested the hypothesis that during enteral feedings very low birth weight (VLBW) infants with a hematocrit ≤28% will experience a decrease in splanchnic rSO2 and splanchnic-cerebral oxygenation ratio (SCOR)...
November 8, 2017: Neonatology
https://www.readbyqxmd.com/read/29125460/nocardia-rhizosphaerihabitans-sp-nov-a-novel-actinomycete-isolated-from-a-coastal-soil
#9
Peng Ding, Juan-Luan Bai, Tian-Tian Wang, Yong Sun, Cheng-Liang Cao, Ji-Hong Jiang, Sheng Qin
An actinomycete strain, designated KLBMP S0039(T), was isolated from the rhizosphere soil of Lycium Linn., collected from the coastal region in Lianyungang, Jiangsu Province, eastern PR China, and was studied to determine its taxonomic position. The isolate showed a combination of morphological and chemotaxonomic properties typical of the members of the genus Nocardia. The cell wall contained meso-diaminopimelic acid as the diagnostic diamino acid and the whole-cell sugars were galactose, arabinose, glucose and ribose...
November 10, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/29125100/effects-of-force-and-inflammatory-factors-on-the-expressions-of-osteogenesis-regulators-in-human-periodontal-ligament-cells
#10
Hua-Jing Zhang, Sheng-Nan Li, Xiao-Nan Xu, Ding Zhang
Objective To observe the effects of force signals and inflammatory cytokines on the expressions of functional proteins during the differentiation of periodontal ligament cells(PDLCs) into osteoclasts. Methods The caries-free premolars that needed to be removed for orthodontic treatment were collected,human periodontal ligament cells were cultured in vitro.Human PDLCs were exposed to inflammatory cytokines including interleukin(IL)-1β,-6,-23,and tumor necrosis factor alpha(TNF-α). Cyclicmechanical tension with a maximum 5% elongation for different durations(0,2,4,8,12,and 24 hours) were applied...
October 30, 2017: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/29115572/talens-mediated-homozygous-ccr5%C3%AE-32-mutations-endow-cd4-u87-cells-with-resistance-against-hiv%C3%A2-1-infection
#11
Ai Qing Yu, Yan Ding, Zhi Yong Lu, Yan Zhe Hao, Zhi Ping Teng, Shi Rong Yan, Dong Sheng Li, Yi Zeng
Since evidence suggests that transplantation of bone marrow stem cells with the C‑C chemokine receptor type 5 (CCR5)Δ32/Δ32 genotype may cure patients infected with human immunodeficiency virus (HIV)‑1, the present study aimed to reproduce the CCR5Δ32 mutation in cluster of differentiation (CD)4+ U87 cells using genome engineering methods. A modified transcription activator‑like effector nucleases (TALENs) technique, combined with homologous recombination for site‑specific, size‑controlled and homozygous DNA deletions, was used to reproduce the homozygous CCR5Δ32 mutation in CD4+ U87 cells...
October 26, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29113338/mir-23a-modulates-x-linked-inhibitor-of-apoptosis-mediated-autophagy-in-human-luminal-breast-cancer-cell-lines
#12
Ping Chen, Yin-Huan He, Xing Huang, Si-Qi Tao, Xiao-Nan Wang, Hong Yan, Ke-Shuo Ding, Peter E Lobie, Wen-Yong Wu, Zheng-Sheng Wu
Autophagy is a conserved multi-step lysosomal process that is induced by diverse stimuli including cellular nutrient deficiency. X-linked inhibitor of apoptosis (XIAP) promotes cell survival and recently has been demonstrated to suppress autophagy. Herein, we examined regulation of XIAP-mediated autophagy in breast cancer cells and determined the underlying molecular mechanism. To investigate this process, autophagy of breast cancer cells was induced by Earle's balanced salt solution (EBSS). We observed discordant expression of XIAP mRNA and protein in the autophagic process induced by EBSS, suggesting XIAP may be regulated at a post-transcriptional level...
October 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/29113183/function-of-the-macrophage-capping-protein-in-colorectal-carcinoma
#13
Wei Wu, Jingdi Chen, Qianshan Ding, Sheng Yang, Jianping Wang, Honggang Yu, Jun Lin
To investigate the role of macrophage-capping protein (CapG) in the development and progression of colorectal carcinoma (CRC), immunohistochemistry (IHC), Kaplan-Meier survival analysis, wound healing and Transwell migration assays were performed. The IHC results demonstrated that CapG was relatively highly expressed in CRC tissue compared with non-tumor tissue (P<0.001), and that the expression of CapG was significantly associated with the tumor site, differentiation, lymph node metastasis and clinical stage (P=0...
November 2017: Oncology Letters
https://www.readbyqxmd.com/read/29107439/effects-of-exercise-improves-muscle-strength-and-fat-mass-in-patients-with-high-fracture-risk-a-randomized-control-trial
#14
Ding-Cheng Chan, Chirn-Bin Chang, Der-Sheng Han, Cian-Hui Hong, Jawl-Shan Hwang, Keh-Sung Tsai, Rong-Sen Yang
BACKGROUND: The deterioration of the musculoskeletal system imposes significant impact on physical activity. Exercise is an important strategy which minimizes these changes. It is not clear which type of exercise provides better improvement on low physical performance, low muscle mass and low strength of sarcopenia. We aim to develop an integrated care (IC) model and compare its relative efficacy in limb fat free mass, muscle strength, and physical performance with low extremities exercise (LEE) in community dwelling older adults with high risk of fractures (Fracture Risk Assessment Tool (FRAX(®))) ≧3% for hip fracture, ≧20% for major osteoporotic fracture or 1-min osteoporosis risk test (≧1 point) or fall (≧2 falls in previous year)...
October 26, 2017: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/29105463/-moxibustion-improves-learning-ability-by-regulating-hippocampal-neurotrophic-factor-expression-and-notch-signaling-in-vascular-dementia-rats
#15
Ying Wang, Sheng-Chao Cai, Xiao-Ge Song, Wan-Li Zhu, Kun Yang, Jian-Jian Qian, Nuo-Nuo Ding
OBJECTIVE: To observe the effect of moxibustion on the learning ability and expression of neurotrophic factors and Notch signaling in vascular dementia (VD) rats, so as to explore its neurogenesis mechanism underlying improvement of VD. METHODS: Sixty SD rats were equally and randomly divided into sham operation (sham), model, medication and moxibustion groups (n=15 rats/group). The VD model was established by occlusion of the bilateral cervical common arteries and reperfusion...
October 25, 2017: Zhen Ci Yan Jiu, Acupuncture Research
https://www.readbyqxmd.com/read/29104491/distinct-effects-of-ca-2-sparks-on-cerebral-artery-and-airway-smooth-muscle-cell-tone-in-mice-and-humans
#16
Qing-Yang Zhao, Yong-Bo Peng, Xiao-Jing Luo, Xi Luo, Hao Xu, Ming-Yu Wei, Qiu-Ju Jiang, Wen-Er Li, Li-Qun Ma, Jin-Chao Xu, Xiao-Cao Liu, Dun-An Zang, Yu-San She, He Zhu, Jinhua Shen, Ping Zhao, Lu Xue, Meng-Fei Yu, Weiwei Chen, Ping Zhang, Xiangning Fu, Jingyu Chen, Xiaowei Nie, Chenyou Shen, Shu Chen, Shanshan Chen, Jingcao Chen, Sheng Hu, Chunbin Zou, Gangjian Qin, Ying Fang, Jiuping Ding, Guangju Ji, Yun-Min Zheng, Tengyao Song, Yong-Xiao Wang, Qing-Hua Liu
The effects of Ca(2+) sparks on cerebral artery smooth muscle cells (CASMCs) and airway smooth muscle cells (ASMCs) tone, as well as the underlying mechanisms, are not clear. In this investigation, we elucidated the underlying mechanisms of the distinct effects of Ca(2+) sparks on cerebral artery smooth muscle cells (CASMCs) and airway smooth muscle cells (ASMCs) tone. In CASMCs, owing to the functional loss of Ca(2+)-activated Cl(-) (Clca) channels, Ca(2+) sparks activated large-conductance Ca(2+)-activated K(+) channels (BKs), resulting in a decreases in tone against a spontaneous depolarization-caused high tone in the resting state...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/29102607/prevalence-of-vision-impairment-in-older-adults-in-rural-china-in-2014-and-comparisons-with-the-2006-china-nine-province-survey
#17
Jialiang Zhao, Xiao Xu, Leon B Ellwein, Ning Cai, Huaijin Guan, Mingguang He, Ping Liu, Jianhua Lv, Xunlun Sheng, Peizeng Yang, Jinglin Yi, Mei Yang, Rui Zhang, Xiaohu Ding, Liping Du, Fengrong Li, Hong Lu, Wenqiang Shao, Junwei Wang, Yuansheng Yuan, Rui Zhou, Wenjuan Zhuang, Lei An
PURPOSE: Estimate the prevalence of vision impairment and blindness in 2014 among older adults in rural China with comparisons with the 2006 Nine-Province Survey. DESIGN: Population-based, cross-sectional study. METHODS: Geographical cluster sampling was used in randomly selecting residents from a rural county or semi-rural district within nine provinces: Beijing, Jiangsu, Guangdong, Heilongjiang, Jiangxi, Hebei, Ningxia, Chongqing and Yunnan...
November 1, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29102535/bisphenol-af-negatively-affects-oocyte-maturation-of-mouse-in-vitro-through-increasing-oxidative-stress-and-dna-damage
#18
Zhi-Ming Ding, Xiao-Fei Jiao, Di Wu, Jia-Yu Zhang, Fan Chen, Yong-Sheng Wang, Chun-Jie Huang, Shou-Xin Zhang, Xiang Li, Li-Jun Huo
Bisphenol AF (BPAF) is commonly used in industry production as a substitute for Bisphenol A (BPA). Many studies showed that BPAF negatively affect some physiological processes in humans and animals. However, the effects of BPAF on oocyte maturation and its possible mechanisms are sparsely understood. In the present study, we found that 100 μM BPAF exposure affect oocyte maturation with a decreased first polar body extrusion (PBE) rate. Immunofluorescence study displayed that BPAF exposure disrupt the spindle morphology through affecting the function of microtubule organizing centers (MTOCs), which was confirmed by the dysfunction of γ-tubulin and phosphorylated mitogen-activated protein kinase (p-MAPK)...
November 2, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29101032/p-q511l-mutation-of-hnf1%C3%AE-in-hepatocellular-carcinoma-suppresses-the-transcriptional-activity-and-the-anti-tumor-effect-of-hnf1%C3%AE
#19
Chen-Hong Ding, Long-Fei Deng, Fei Chen, Kai Ding, Wan-Sheng Chen, Wei-Fen Xie, Xin Zhang
Hepatocyte nuclear factor 1α (HNF1α) is a liver-enriched transcription factor that regulates many aspects of hepatocyte functions. Our previous studies have demonstrated that HNF1α has potent therapeutic effects on hepatocellular carcinoma (HCC). Mutations in HNF1α gene are frequently associated with maturity-onset diabetes of the young type 3 (MODY3) and hepatocellular adenomas. However, the association of HNF1α mutation and HCC remains elusive. In this study, the point mutation of HNF1α gene with c...
October 31, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29100798/benzo-c-1-2-5-thiadiazole-derivatives-a-new-class-of-potent-src-homology-2-domain-containing-protein-tyrosine-phosphatase-2-shp2-inhibitors
#20
Wen-Long Wang, Xiao-Yu Chen, Ya Gao, Li-Xin Gao, Li Sheng, Jingyu Zhu, Lei Xu, Zhen-Zhong Ding, Chao Zhang, Jing-Ya Li, Jia Li, Yu-Bo Zhou
The Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2) is an oncogenic phosphatase linked to various kinds of cancers. Consequently, SHP2 has emerged as a promising target for novel anti-cancer agents. Using scaffold-hopping strategy, a series of benzo[c][1,2,5]thiadiazole derivatives was designed from PTP1B inhibitors with 1H-2,3-Dihydroperimidine motif, synthesized and evaluated their biological activities against PTP1B and SHP2. Among them, the representative compound 11g displayed SHP2 inhibitory activity with IC50 of 2...
October 26, 2017: Bioorganic & Medicinal Chemistry Letters
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