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https://www.readbyqxmd.com/read/29780166/nudt21-negatively-regulates-psmb2-and-cxxc5-by-alternative-polyadenylation-and-contributes-to-hepatocellular-carcinoma-suppression
#1
Sheng Tan, Hua Li, Weijie Zhang, Yunying Shao, Yuan Liu, Haiyang Guan, Jun Wu, Yani Kang, Junsong Zhao, Qing Yu, Yunzhao Gu, Keshuo Ding, Min Zhang, Wenchang Qian, Yong Zhu, Huayong Cai, Changyu Chen, Peter E Lobie, Xiaodong Zhao, Jielin Sun, Tao Zhu
Alternative polyadenylation (APA) is an important post-transcriptional regulatory mechanism and involved in many diseases, including cancer. CFIm25, a subunit of the cleavage factor I encoded by NUDT21, is required for 3'RNA cleavage and polyadenylation. Although it has been recently reported to be involved in glioblastoma tumor suppression, its roles and the underlying functional mechanism remain unclear in other types of cancer. In this study, we characterized NUDT21 in hepatocellular carcinoma (HCC). Reduced expression of NUDT21 was observed in HCC tissue compared to adjacent non-tumorous compartment...
May 21, 2018: Oncogene
https://www.readbyqxmd.com/read/29777555/impact-of-nicu-oral-feeding-on-neuropsychomotor-outcomes-at-9-months-of-corrected-age-in-chinese-low-birth-weight-preterm-infants-a-retrospective-study
#2
Wenwen Ding, Lijin Zhao, Nan Sheng, Jiali Ma, Ying Zhang
AIMS AND OBJECTIVES: To examine the changes in neuropsychomotor development and investigate the effect of feeding progression in Neonatal Intensive Care Unit (NICU) on neuropsychomotor outcomes in low-birth-weight preterm infants within 9 months of corrected age. BACKGROUND: Low-birth-weight (LBW) preterm infants (<37 weeks of gestation and birth weight < 2500 g) are at a high risk for neuropsychomotor development delay. Therefore, exploring NICU practices related to neuropsychomotor development is important...
May 18, 2018: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29776962/shp-1-acts-as-a-tumor-suppressor-in-hepatocarcinogenesis-and-hcc-progression
#3
Liang-Zhi Wen, Kai Ding, Ze-Rui Wang, Chen-Hong Ding, Shu-Juan Lei, Jin-Pei Liu, Chuan Yin, Ping-Fang Hu, Jin Ding, Wan-Sheng Chen, Xin Zhang, Wei-Fen Xie
Src homology region 2 (SH2) domain-containing phosphatase 1 (SHP-1, also known as PTPN6), is a nonreceptor protein tyrosine phosphatase that acts as a negative regulator of inflammation. Emerging evidence indicates that SHP-1 plays a role in inhibiting the progression of hepatocellular carcinoma (HCC). However, the role of SHP-1 in hepatocarcinogenesis remains unknown. Here we find that levels of SHP-1 are significantly downregulated in human HCC tissues compared with those in noncancerous tissues (P &lt; 0...
May 18, 2018: Cancer Research
https://www.readbyqxmd.com/read/29775494/osa-mir164a-targets-osnac60-and-negatively-regulates-rice-immunity-against-the-blast-fungus-magnaporthe-oryzae
#4
Zhaoyun Wang, Yeqiang Xia, Siyuan Lin, Yanru Wang, Baohuan Guo, Xiaoning Song, Shaochen Ding, Liyu Zheng, Ruiying Feng, Shulin Chen, Yalin Bao, Cong Sheng, Xin Zhang, Jianguo Wu, Dongdong Niu, Hailing Jin, Hongwei Zhao
Exploring the regulatory mechanism played by endogenous rice miRNAs in defense responses against the blast disease is of great significance in both resistant variety breeding and disease control management. We identified rice defense-related miRNAs by comparing rice miRNA expression patterns before and after Magnaporthe oryzae strain Guy11 infection. We discovered that osa-miR164a expression reduced upon Guy11 infection at both early and late stages, which was perfectly associated with the induced expression of its target gene, OsNAC60...
May 18, 2018: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/29774144/effects-of-passage-and-cryopreservation-on-neurotrophic-factor-secretion-from-choroid-plexus-epithelial-cells
#5
Feng Zhao, Xiao-Yan Ding, Feng Wu, Xiao-Hui Li, Yu-Huan Li, Sheng-Li Huang
The aim of the present study was to evaluate the effects of passage and cryopreservation of choroid plexus epithelial cells on their secretion of neurotrophic factors. Choroid plexus epithelial cells were cryopreserved and thawed following primary culture or passage cultured for up to two passages. The supernatant of primary, first/second passage and cryopreserved-thawed choroid plexus epithelial cells was collected when cells reached 80-90% confluence. ELISA was used to quantify brain-derived neurotrophic factor (BDNF), glial cell-derived neurotrophic factor (GDNF), nerve growth factor (NGF) and ciliary neurotrophic factor (CNTF) levels in the cell supernatant...
June 2018: Biomedical Reports
https://www.readbyqxmd.com/read/29774121/mir-33-promotes-myocardial-fibrosis-by-inhibiting-mmp16-and-stimulating-p38-mapk-signaling
#6
Zhen Chen, Hua-Sheng Ding, Xin Guo, Jing-Jing Shen, Di Fan, Yan Huang, Cong-Xin Huang
Myocardial fibrosis occurs in the late stages of many cardiovascular diseases, and appears to be stimulated by various microRNAs (miRNAs). We previously found that miR-33 may stimulate cardiac remodeling. Here, we examined the involvement of miR-33 in myocardial fibrosis. Proximal left coronary descending artery occlusion was performed in rat, and antagomiR-33a was injected. Primary cardiac fibroblasts were cultured and transfected with miR-33a mimics and inhibitors. miR-33a levels were increased in the rat after surgery, and collagen deposition and heart fibrosis were observed in vivo ...
April 24, 2018: Oncotarget
https://www.readbyqxmd.com/read/29771118/escherichia-coli-fiber-sensors-using-concentrated-dielectrophoretic-force-with-optical-defocusing-method
#7
Yi-Hsin Tai, Chia-Wei Lee, Dao-Ming Chang, Yu-Sheng Lai, Ding-Wei Huang, Pei-Kuen Wei
A sensitive tapered optical fiber tip combined with dielectrophoretic (DEP) trapping was used to rapid and label-free detection of bacteria in water. The angular spectrum of optical field at the fiber tip was changed with surrounding refractive index (RI). By measuring far-field intensity change at the defocus plane, the intensity sensitivity was up to 95,200 %/RIU (RI unit) and the detection limit was 2.1 × 10-6 RIU at 0.2% intensity stability. By applying an AC voltage to a Ti/Al coated fiber tip and an indium-tin-oxide glass, the DEP force effectively trapped the Escherichia coli (E...
May 17, 2018: ACS Sensors
https://www.readbyqxmd.com/read/29768254/neuroprotection-against-hypoxic-ischemic-injury-%C3%AE-opioid-receptors-and-bdnf-trkb-pathway
#8
Shiying Sheng, Jingzhong Huang, Yi Ren, Feng Zhi, Xuansong Tian, Guoqiang Wen, Guanghong Ding, Terry C Xia, Fei Hua, Ying Xia
The delta-opioid receptor (DOR) is one of three classic opioid receptors in the opioid system. It was traditionally thought to be primarily involved in modulating the transmission of messages along pain signaling pathway. Although there were scattered studies on its other neural functions, inconsistent results and contradicting conclusions were found in past literatures, especially in terms of DOR's role in a hypoxic/ischemic brain. Taking inspiration from the finding that the turtle brain exhibits a higher DOR density and greater tolerance to hypoxic/ischemic insult than the mammalian brain, we clarified DOR's specific role in the brain against hypoxic/ischemic injury and reconciled previous controversies in this aspect...
May 11, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29767517/formation-of-zno-4-tetrahedra-and-zno-6-octahedra-in-tezno-3-synthesized-under-high-pressure
#9
Jianhong Dai, Xudong Shen, Zhehong Liu, Qing Zhao, Xiao Wang, Cheng Dong, Yuecheng Bian, Wei Ding, Zhigao Sheng, Masaki Azuma, Youwen Long
A new TeZnO3 phase was synthesized by high-pressure techniques. Different from the ambient-pressure orthorhombic phase composed of ZnO5 units, the current high-pressure one crystallizes to a monoclinic structure with space group P21 / n. Moreover, both ZnO4 tetrahedral and ZnO6 octahedral polyhedra are found to occur in this new phase, providing a unique Zn-based material system that simultaneously possesses two distinct coordinated units. Because the outermost orbitals are fully occupied for both Zn2+ and Te4+ , the compound exhibits diamagnetism and strong insulating behavior with a wide bandgap as large as 6...
May 16, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/29763751/integration-of-summary-data-from-gwas-and-eqtl-studies-identified-novel-causal-bmd-genes-with-functional-predictions
#10
Xiang-He Meng, Xiang-Ding Chen, Jonathan Greenbaum, Qin Zeng, Sheng-Lan You, Hong-Mei Xiao, Li-Jun Tan, Hong-Wen Deng
PURPOSE: Osteoporosis is a common global health problem characterized by low bone mineral density (BMD) and increased risk of fracture. Genome-wide association studies (GWAS) have identified >100 genetic loci associated with BMD. However, the functional genes responsible for most associations remain largely unknown. We conducted an innovative summary statistic data-based Mendelian randomization (SMR) analysis to identify novel causal genes associated with BMD and explored their potential functional significance...
May 12, 2018: Bone
https://www.readbyqxmd.com/read/29755345/analogous-%C3%AE-carboline-alkaloids-harmaline-and-harmine-ameliorate-scopolamine-induced-cognition-dysfunction-by-attenuating-acetylcholinesterase-activity-oxidative-stress-and-inflammation-in-mice
#11
Shu-Ping Li, Yu-Wen Wang, Sheng-Lan Qi, Yun-Peng Zhang, Gang Deng, Wen-Zheng Ding, Chao Ma, Qi-Yan Lin, Hui-Da Guan, Wei Liu, Xue-Mei Cheng, Chang-Hong Wang
The analogous β-carboline alkaloids, harmaline (HAL) and harmine (HAR), possess a variety of biological properties, including acetylcholinesterase (AChE) inhibitory activity, antioxidant, anti-inflammatory, and many others, and have great potential for treating Alzheimer's disease (AD). However, studies have showed that the two compounds have similar structures and in vitro AChE inhibitory activities but with significant difference in bioavailability. The objective of this study was to comparatively investigate the effects of HAL and HAR in memory deficits of scopolamine-induced mice...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29744291/poly-rc-binding-protein-2-pcbp2-promotes-the-viability-of-human-gastric-cancer-cells-by-regulating-cdk2
#12
Changyu Chen, Jun Lei, Qiang Zheng, Sheng Tan, Keshuo Ding, Changjun Yu
Survival rates for patients with gastric cancer, especially the advanced form, remain poor and the development of targeted treatments is hampered by a lack of efficient biological targets. Poly(rC) binding protein 2 (PCBP2) is an RNA-binding protein that contributes to mRNA stabilization, translational silencing and enhancement and it has been implicated as a promoter of gastric cancer growth. In the present study, we demonstrated that the expression level of PCBP2 was higher in human gastric cancer tissues compared to adjacent normal gastric tissues...
May 2018: FEBS Open Bio
https://www.readbyqxmd.com/read/29736306/lmo4-mediates-trastuzumab-resistance-in-her2-positive-breast-cancer-cells
#13
Keshuo Ding, Zhengsheng Wu, Xiaocan Li, Youjing Sheng, Xiaonan Wang, Sheng Tan
Breast cancer is the leading cause of cancer-related mortality in women worldwide. Trastuzumab (Herceptin) is an effective antibody drug for HER2 positive breast cancer; de novo or acquired trastuzumab resistance retarded the use of trastuzumab for at least 70% of HER2 positive breast cancers. In this study, we reported LMO4 (a member of LIM-only proteins) promoted trastuzumab resistance in human breast cancer cells. Over-expression of LMO4 was observed in acquired trastuzumab resistance breast cancer cells SKBR3 HR and BT474 HR...
2018: American Journal of Cancer Research
https://www.readbyqxmd.com/read/29734031/hydrogen-peroxide-biosensor-based-on-chitosan-2d-layered-double-hydroxide-composite-for-the-determination-of-h-2-o-2
#14
Jian Yuan, Sheng Xu, Hong-Yan Zeng, Xi Cao, A Dan Pan, Gao-Fei Xiao, Peng-Xuan Ding
The composites (LDH-CMC) composed of carboxymethyl chitosan (CMC) and 2D ZnAl layered double hydroxide (LDH) were successfully prepared using the one-step urea method; these composites were characterized by XRD, FT-IR, UV-vis DRS, SEM, BJH/BET, TG-DTG and pHzpc analyses, cyclic voltammetry, and electrochemical impedance spectroscopy. The use of CMC could impact the textural and surface chemical properties of the LDH-CMC composites, where the composites still maintained the 2D layered structure. Incorporating a moderate amount of CMC could increase both the surface area and the permanent charge density of the composites, leading to improved electrochemical performances...
April 23, 2018: Bioelectrochemistry
https://www.readbyqxmd.com/read/29729458/burr-hole-craniostomy-with-t-tube-drainageas-a-surgical-treatment-for-chronic-subdural-hematoma
#15
Wenchao Lu, Hui Wang, Tao Wu, Xudong Sheng, Zhibin Ding, Gangzhu Xu
OBJECTIVE: To investigate the effect of burr-hole craniostomy with T-tube drainage to treat chronic subdural hematoma(CSDH). METHODS: Eighty-seven patients with CSDH that were recruited from January 2012 to June 2017 at the Department of Neurosurgery, The First Affiliated Hospital of Xi'an Medical University, were divided into two groups according to the method of drainage: T-tube drainage system (n = 45)and conventional subdural drainage system (n = 42). Retrospective analysis of clinical data and efficacy was performed between the two groups...
May 2, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29728334/intracoronary-infusion-of-alprostadil-and-nitroglycerin-with-targeted-perfusion-microcatheter-in-stemi-patients-with-coronary-slow-flow-phenomenon
#16
Xincheng Sheng, Song Ding, Heng Ge, Yujun Sun, Lingcong Kong, Jie He, Jun Pu, Ben He
BACKGROUND: The treating aims of ST-segment elevation myocardial infarction (STEMI) are vessels recanalization and coronary flow restoration. Coronary slow flow phenomenon (CSFP) is one of the common complications in STEMI patients after percutaneous coronary intervention (PCI) and leads to a higher incidence of adverse clinical outcomes. Alprostadil is a kind of liposomal prostaglandin E1 with beneficial effects on vasodilation, platelet disaggregation and fibrinolysis. But it still remains unclear that whether alprostadil can improve the coronary perfusion in STEMI patients with CSFP after PCI...
April 25, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29726871/engineering-nanoporous-organic-frameworks-to-stabilize-naked-au-clusters-a-charge-modulation-approach
#17
Shunmin Ding, Chengcheng Tian, Xiang Zhu, Huize Wang, Hai Wang, Carter W Abney, Ning Zhang, Sheng Dai
A simple charge modulation approach has been developed to stabilize naked Au clusters on a nanoporous conjugated organic network. Through engineering pore walls with regulated charges, the controllable growth of Au nanoclusters has been realized. The resulting supported catalyst exhibits excellent performance in the aerobic oxidation of alcohols.
May 4, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29726643/-expressions-of-interleukin-17-and-interleukin-8-in-the-prostatic-tissue-of-the-patients-with-bph-or-bph-with-inflammation
#18
Rui Gao, Qi-Xiang Liu, Hui-Liang Zhou, Lin-Sheng Cao, Tao Jiang, Song-Xi Tang, Yi-Lang Ding
Objective: To investigate the expressions of interleukin-17 (IL-17) and interleukin-8 (IL-8) in benign prostatic hyperplasia (BPH) and BPH complicated with histological inflammation and their significance. METHODS: According to the results of HE staining, we divided 60 cases of BPH treated by transurethral resection of the prostate (TURP) into a BPH group (n = 23) and a BPH with inflammation group (n = 37). We analyzed the clinical data of the patients and determined the mRNA and protein expressions of IL-17 and IL-8 by immunohistochemistry, real-time fluorescence quantitative PCR, and Western blot, respectively...
August 2017: Zhonghua Nan Ke Xue, National Journal of Andrology
https://www.readbyqxmd.com/read/29723453/-erectile-dysfunction-and-psychological-status-in-infertile-males
#19
Jian-Xiong Ma, Bin Wang, Jin Dang, Xiang-Bin Li, Jin Ding, Yu-Tian Zhu, Ji-Sheng Wang, Hai-Song Li
Objective: To investigate the relationship of erectile dysfunction (ED) with psychological factors in male patients with infertility. METHODS: We conducted a questionnaire investigation among 252 male patients with infertility, which involved the general condition, results of semen routine examination, sexual life, and scores in IIEF-5, self-reported 9-item patient health questionnaire (PHQ-9) and 7-item generalized anxiety disorder scale (GAD-7). We analyzed the prevalence of ED, depression, and anxiety and their correlations among the patients in comparison with 100 fertile male controls...
July 2017: Zhonghua Nan Ke Xue, National Journal of Andrology
https://www.readbyqxmd.com/read/29722976/gmars-t-enables-multimodal-subdiffraction-structural-and-functional-fluorescence-imaging-in-live-cells
#20
Sheng Wang, Xuanze Chen, Lei Chang, Miao Ding, Ruiying Xue, Haifeng Duan, Yujie Sun
Fluorescent probes with multimodal and multilevel imaging capabilities are highly valuable as imaging with such probes not only can obtain new layers of information but also enable cross-validation of results under different experimental conditions. In recent years, the development of genetically-encoded reversibly photoswitchable fluorescent proteins (RSFPs) has greatly promoted the application of various kinds of live-cell nanoscopy approaches, including reversible saturable optical fluorescence transitions (RESOLFT) and stochastic optical fluctuation imaging (SOFI)...
May 3, 2018: Analytical Chemistry
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