keyword
MENU ▼
Read by QxMD icon Read
search

sheng ding

keyword
https://www.readbyqxmd.com/read/28212342/a-review-on-the-phytochemistry-pharmacology-and-pharmacokinetics-of-amentoflavone-a-naturally-occurring-biflavonoid
#1
REVIEW
Sheng Yu, Hui Yan, Li Zhang, Mingqiu Shan, Peidong Chen, Anwei Ding, Sam Fong Yau Li
Amentoflavone (C30H18O10) is a well-known biflavonoid occurring in many natural plants. This polyphenolic compound has been discovered to have some important bioactivities, including anti-inflammation, anti-oxidation, anti-diabetes, and anti-senescence effects on many important reactions in the cardiovascular and central nervous system, etc. Over 120 plants have been found to contain this bioactive component, such as Selaginellaceae, Cupressaceae, Euphorbiaceae, Podocarpaceae, and Calophyllaceae plant families...
February 16, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28211804/comparison-of-elastography-based-on-transvaginal-ultrasound-and-mri-in-assessing-parametrial-invasion-of-cervical-cancer
#2
Xi Ma, Qi Li, Jian-Liang Wang, Jun Shao, Yu-Chun Zhu, Wei Ding, Hou-Sheng Zhang, Hong-Yan Wang, Jun-Kang Shen
OBJECTIVE: The purpose of this study was to evaluate the clinical value of transvaginal elastography (TVES) combined with high-resolution transvaginal ultrasound (TVS) in the detection of parametrial invasion in cervical cancer and to compare the diagnostic performance with magnetic resonance imaging (MRI). MATERIALS AND METHODS: 52 women with histologically confirmed cervical cancer over a 2-year period were staged using International Federation of Gynecology and Obstetrics (FIGO) criteria and underwent MRI and TVES combined with TVS according to a standardized protocol before treatment...
February 17, 2017: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/28197202/expression-changes-of-nerve-cell-adhesion-molecules-l1-and-semaphorin-3a-after-peripheral-nerve-injury
#3
Qian-Ru He, Meng Cong, Qing-Zhong Chen, Ya-Feng Sheng, Jian Li, Qi Zhang, Fei Ding, Yan-Pei Gong
The expression of nerve cell adhesion molecule L1 in the neuronal growth cone of the central nervous system is strongly associated with the direction of growth of the axon, but its role in the regeneration of the peripheral nerve is still unknown. This study explored the problem in a femoral nerve section model in rats. L1 and semaphorin 3A mRNA and protein expressions were measured over the 4-week recovery period. Quantitative polymerase chain reaction showed that nerve cell adhesion molecule L1 expression was higher in the sensory nerves than in motor nerves at 2 weeks after injury, but vice versa for the expression of semaphorin 3A...
December 2016: Neural Regeneration Research
https://www.readbyqxmd.com/read/28188414/a-potential-panel-of-four-long-noncoding-rna-signature-in-prostate-cancer-predicts-biochemical-recurrence-free-survival-and-disease-free-survival
#4
Tian-Bao Huang, Chuan-Peng Dong, Guang-Chen Zhou, Sheng-Ming Lu, Yang Luan, Xiao Gu, Lei Liu, Xue-Fei Ding
PURPOSES: Growing evidences showed that lncRNAs abnormally expressed in cancer tissues and played irreplaceable roles in tumorigenesis, progression and metastasis. In present study, we aimed to identify lncRNA expression signature that can predict biochemical recurrence-free (BCR-free) survival of prostate cancer (PCa) patients. METHODS: A total of 291 patients with pathologic confirmed PCa in The Cancer Genome Atlas dataset were recruited and included. With the specific risk score formula, patients were further classified into high-risk group and low-risk group...
February 10, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28178195/overexpression-of-skp2-inhibits-the-radiation-induced-bystander-effects-of-esophageal-carcinoma
#5
Xiao-Chun Wang, Tie-Jun Zhang, Zi-Jian Guo, Chang-Yan Xiao, Xiao-Wen Ding, Fang Fang, Wen-Tao Sheng, Xu Shu, Jue Li
BACKGROUND: To investigate the effects of S-phase kinase protein 2 (SKP2) expression on the radiation induced bystander effect (RIBE) in esophageal cancer (EC) cells. MATERIALS AND METHODS: Western blot was used to detect the levels of SKP2, Rad51, and Ku70 in EC cells. Positive transfection, RNAi, micronucleus (MN), and γ-H2AX focus formation assay were used to investigate the effects of SKP2 on RIBE induced by irradiated cells. RESULTS: We found a significant negative correlation between SKP2 expression and MN frequency (p < 0...
February 6, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28177914/statins-in-conditions-other-than-hypocholesterolemic-effects-for-chronic-subdural-hematoma-therapy-old-drug-new-tricks
#6
Hai Zou, Xing-Xing Zhu, Ya-Hui Ding, Guo-Bing Zhang, Yu Geng, Dong-Sheng Huang
Chronic subdural hematoma (CSDH) is one of the most common intracranial hematomas worldwide with a high incidence in the general population. However, the optimum treatment for CSDH is Burr-hole drainage with or without rinse Considering the poor outcomes of CSDH in aged patients, and ambiguous prediction of recurrence in many sides of recurrent CSDHs who have been analyzed, new effective therapies are needed for those CSDHs who are predicated to have poor prognosis for surgery and/or have a higher risk of recurrence...
January 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28177875/metabolomic-signature-associated-with-reproduction-regulated-aging-in-caenorhabditis-elegans
#7
Qin-Li Wan, Xiaohuo Shi, Jiangxin Liu, Ai-Jun Ding, Yuan-Zhu Pu, Zhigang Li, Gui-Sheng Wu, Huai-Rong Luo
In Caenorhabditis elegans (C. elegans), ablation of germline stem cells (GSCs) leads to infertility, which extends lifespan. It has been reported that aging and reproduction are both inextricably associated with metabolism. However, few studies have investigated the roles of polar small molecules metabolism in regulating longevity by reproduction. In this work, we combined the nuclear magnetic resonance (NMR) and ultra-performance liquid chromatography-mass spectrometry (UPLC-MS) to profile the water-soluble metabolome in C...
February 6, 2017: Aging
https://www.readbyqxmd.com/read/28165807/preparation-of-endostatin-loaded-chitosan-nanoparticles-and-evaluation-of-the-antitumor-effect-of-such-nanoparticles-on-the-lewis-lung-cancer-model
#8
Rui-Lin Ding, Fang Xie, Yue Hu, Shao-Zhi Fu, Jing-Bo Wu, Juan Fan, Wen-Feng He, Yu He, Ling-Lin Yang, Sheng Lin, Qing-Lian Wen
The purpose of this study was to prepare ES-loaded chitosan nanoparticles (ES-NPs) and evaluate the antitumor effect of these particles on the Lewis lung cancer model. ES-NPs were prepared by a simple ionic cross-linking method. The characterization of the ES-NPs, including size distribution, zeta potential, loading efficiency and encapsulation efficiency (EE), was performed. An in vitro release test was also used to determine the release behavior of the ES-NPs. Cell viability and cell migration were assayed to detect the in vitro antiangiogenic effect of ES-NPs...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28157629/the-epigenetically-regulated-mir-34a-targeting-c-src-suppresses-raf-mek-erk-signaling-pathway-in-k-562-cells
#9
Yang Yang, Li Ding, Zi-Kuan Guo, Xiao-Li Zheng, Li-Sheng Wang, Hui-Yan Sun, Zhan-Guo Jin, Heng-Xiang Wang
Previous reports show that miR-34a suppressed K-562 cell proliferation and contributed to megakaryocytic differentiation of K-562 cells. Here, we reported that miR-34a, a tumor suppressor gene, is down-regulated in the K-562 cells and chronic myeloid leukemia (CML) patients due to aberrant DNA hypermethylation. c-SRC is a target of miR-34a. Restoring miR-34a expression resulted in down-regulation of c-SRC and phosphorylated (Tyr416) c-SRC protein in K-562 cells, which consequently triggered suppression of the RAF/MEK/ERK signaling pathway to decrease cell proliferation...
January 22, 2017: Leukemia Research
https://www.readbyqxmd.com/read/28154007/loss-of-endothelial-cxcr7-impairs-vascular-homeostasis-and-cardiac-remodeling-after-myocardial-infarction-implications-for-cardiovascular-drug-discovery
#10
Huifeng Hao, Sheng Hu, Hong Chen, Dawei Bu, Liyuan Zhu, Chuansheng Xu, Fei Chu, Xingyu Huo, Yue Tang, Xiaogang Sun, Bisen Ding, Depei Liu, Shengshou Hu, Miao Wang
BACKGROUND: -Genome-wide association studies identified the association of the CXCL12 genetic locus (which encodes the chemokine CXCL12, also known as stromal cell-derived factor 1) with coronary artery disease (CAD) and myocardial infarction (MI). Unlike CXCR4, the classical receptor for CXCL12, the function of CXCR7 (the most recently identified receptor) in vascular responses to injury and in MI remains unclear. METHODS: -Tissue expression of CXCR7 was examined in arteries from mice and humans...
February 2, 2017: Circulation
https://www.readbyqxmd.com/read/28148899/regulation-of-hepatic-pyruvate-dehydrogenase-phosphorylation-in-offspring-glucose-intolerance-induced-by-intrauterine-hyperglycemia
#11
Yong Zhang, Ying Zhang, Guo-Lian Ding, Xin-Mei Liu, Jianping Ye, Jian-Zhong Sheng, Jianxia Fan, He-Feng Huang
AIM: Gestational diabetes mellitus (GDM) has been shown to be associated with a high risk of diabetes in offspring. In mitochondria, the inhibition of pyruvate dehydrogenase (PDH) activity by PDH phosphorylation is involved in the development of diabetes. We aimed to determine the role of PDH phosphorylation in the liver in GDM-induced offspring glucose intolerance. RESULTS: PDH phosphorylation was increased in lymphocytes from the umbilical cord blood of the GDM patients and in high glucose-treated hepatic cells...
January 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28144936/multiple-variants-in-5q31-1-are-associated-with-systemic-lupus-erythematosus-susceptibility-and-sub-phenotypes-in-the-han-chinese-population
#12
L Wen, Z Zhu, C Yang, L Liu, X Zuo, D L Morris, J Dou, L Ye, Y Cheng, H Guo, H Huang, Y Lin, C Zhu, L Tang, M Chen, Y Zhou, Y Ding, B Liang, F Zhou, J Gao, X Tang, X Zheng, W Wang, X Yin, H Tang, L Sun, S Yang, X Zhang, Y Sheng, Y Cui
BACKGROUND: A previous study provided evidence for genetic association between PPP2CA on 5q31.1 and systemic lupus erythematosus (SLE) across multi-ancestral cohorts, but failed to find significant evidence for association in the Chinese Han population. OBJECTIVE: To explore the association between this locus and SLE using data from our previously published genome-wide association study (GWAS) of SLE in Han Chinese population. METHODS: SNPs rs7726414 and rs244689 (near TCF7 and PPP2CA in 5q31...
February 1, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28131103/segmental-latissimus-dorsi-free-flap-attempting-to-preserve-function-at-the-donor-site-anatomical-and-clinical-experiences
#13
YiChun Ding, Dong Sheng Cao, XueYing Huang, Juan Xie, HongHong Li
Background The purpose of the present study was to evaluate arm and shoulder function prospectively after transfer of the lateral segment of the latissimus dorsi (LD) muscle. Methods In this study, 20 specimens of LD muscles from 10 cadavers were dissected to determine the relationship between the artery and the nerve. Twenty patients were recruited and functional disability was determined by the Disabilities of Arm, Shoulder, and Hand (DASH), and muscle strength by needle electromyography (EMG) before surgery and at five different time points postoperatively...
January 28, 2017: Journal of Reconstructive Microsurgery
https://www.readbyqxmd.com/read/28130125/histone-methyltransferase-setd2-is-critical-for-the-proliferation-and-differentiation-of-myoblasts
#14
Xin Yi, Ye Tao, Xi Lin, Yuan Dai, Tingli Yang, Xiaojing Yue, Xuejun Jiang, Xiaoyan Li, Ding-Sheng Jiang, Kelsey C Andrade, Jiang Chang
Skeletal muscle cell proliferation and differentiation are tightly regulated. Epigenetic regulation is a major component of the regulatory mechanism governing these processes. Histone modification is part of the epigenetic code used for transcriptional regulation of chromatin through the establishment of an active or repressive state for genes involved in myogenesis in a temporal manner. Here, we uncovered the function of SET domain containing 2 (Setd2), an essential histone 3 lysine 36 trimethyltransferase, in regulating the proliferation and differentiation of myoblasts...
January 24, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28128224/pyrintegrin-induces-soft-tissue-formation-by-transplanted-or-endogenous-cells
#15
Bhranti S Shah, Mo Chen, Takahiro Suzuki, Mildred Embree, Kimi Kong, Chang H Lee, Ling He, Lusai Xiang, Jeffrey A Ahn, Sheng Ding, Jeremy J Mao
Focal adipose deficiency, such as lipoatrophy, lumpectomy or facial trauma, is a formidable challenge in reconstructive medicine, and yet scarcely investigated in experimental studies. Here, we report that Pyrintegrin (Ptn), a 2,4-disubstituted pyrimidine known to promote embryonic stem cells survival, is robustly adipogenic and induces postnatal adipose tissue formation in vivo of transplanted adipose stem/progenitor cells (ASCs) and recruited endogenous cells. In vitro, Ptn stimulated human adipose tissue derived ASCs to differentiate into lipid-laden adipocytes by upregulating peroxisome proliferator-activated receptor (PPARγ) and CCAAT/enhancer-binding protein-α (C/EBPα), with differentiated cells increasingly secreting adiponectin, leptin, glycerol and total triglycerides...
January 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28123425/ankfy1-is-dispensable-for-neural-stem-precursor-cell-development
#16
Chao Weng, Man Ding, Lian-Sheng Chang, Ming-Xin Ren, Hong-Feng Zhang, Zu-Neng Lu, Hui Fu
There are few studies on the membrane protein Ankfy1. We have found Ankfy1 is specifically expressed in neural stem/precursor cells during early development in mice (murine). To further explore Ankfy1 function in neural development, we developed a gene knockout mouse with a mixed Balb/C and C57/BL6 genetic background. Using immunofluorescence and in situ hybridization, neural defects were absent in mixed genetic Ankfy1 null mice during development and in adults up to 2 months old. However, Ankfy1 gene knockout mice with a pure genetic background were found to be lethal in the C57/BL6 inbred mice embryos, even after seven generations of backcrossing...
November 2016: Neural Regeneration Research
https://www.readbyqxmd.com/read/28121120/facile-synthesis-of-carbon-coated-spinel-li4ti5o12-rutile-tio2-composites-as-an-improved-anode-material-in-full-lithium-ion-batteries-with-lifepo4-n-doped-carbon-cathode
#17
Ping Wang, Geng Zhang, Jian Cheng, Ya You, Yong-Ke Li, Cong Ding, Jiang-Jiang Gu, Xin-Sheng Zheng, Chao-Feng Zhang, Fei-Fei Cao
The spinel Li4Ti5O12/rutile-TiO2@carbon (LTO-RTO@C) composites were fabricated via hydrothermal method combined with calcination treatment employing glucose as carbon source. The carbon coating layer and the in-situ formed rutile-TiO2 can effectively enhance the electric conductivity and provide quick Li+ diffusion pathways for Li4Ti5O12. When used as anode material for lithium-ion batteries, the rate capability and cycling stability of LTO-RTO@C composites were improved in comparison with pure Li4Ti5O12 or Li4Ti5O12/rutile-TiO2...
January 25, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28119113/quantitative-proteomics-analysis-of-caenorhabditis-elegans-upon-germ-cell-loss
#18
Yuan-Zhu Pu, Qin-Li Wan, Ai-Jun Ding, Huai-Rong Luo, Gui-Sheng Wu
: The abrogation of the germ cells in Caenorhabditis elegans (C. elegans) by either genetic means or cell ablation results in about 60% increase of longevity. Upon the inhibition of germline stem cell proliferation, certain signaling molecules inhibit the target of rapamycin (TOR), activate the transcription factors including DAF-16, DAF-12, and PHA-4, leading to altered fatty acid lipolysis, autophagy, stress resistance, and the extended lifespan. But the exact cascades and interactions of those signaling pathways are still obscure...
January 21, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28119093/comparison-of-endoscopic-transcanal-myringoplasty-and-endoscopic-type-i-tympanoplasty-in-repairing-medium-sized-tympanic-perforations
#19
Chih-Chieh Tseng, Ming-Tang Lai, Chia-Che Wu, Sheng-Po Yuan, Yi-Fang Ding
OBJECTIVE: The tympanomeatal flap elevation technique has been used in tympanoplasty for decades; however, this procedure has disadvantages. In recent years, endoscopic transcanal myringoplasty (ETM) has been increasingly practiced and has yielded positive results.This study compares the efficacy of ETM and endoscopic type I tympanoplasty (ETT) in repairing medium-sized perforations of the tympanic membrane. METHODS: This retrospective medical record review included patients undergoing surgery for medium-sized perforations of the tympanic membrane from January 1, 2013 to August 1, 2015...
January 21, 2017: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/28111236/prevalence-of-prediabetes-risk-in-offspring-born-to-mothers-with-hyperandrogenism
#20
Shen Tian, Xian-Hua Lin, Yi-Meng Xiong, Miao-E Liu, Tian-Tian Yu, Min Lv, Wei Zhao, Gu-Feng Xu, Guo-Lian Ding, Chen-Ming Xu, Min Jin, Chun Feng, Yan-Ting Wu, Ya-Jing Tan, Qian Gao, Jian Zhang, Cheng Li, Jun Ren, Lu-Yang Jin, Bin Chen, Hong Zhu, Xue-Ying Zhang, Song-Chang Chen, Xin-Mei Liu, Ye Liu, Jun-Yu Zhang, Li Wang, Ping Zhang, Xiao-Jun Chen, Li Jin, Xi Chen, Yi-Cong Meng, Dan-Dan Wu, Hui Lin, Qian Yang, Cheng-Liang Zhou, Xin-Zhu Li, Yi-Yu Wang, Yu-Qian Xiang, Zhi-Wei Liu, Ling Gao, Lu-Ting Chen, Hong-Jie Pan, Rong Li, Fang-Hong Zhang, Lan-Feng Xing, Yi-Min Zhu, Christian Klausen, Peter C K Leung, Ju-Xue Li, Fei Sun, Jian-Zhong Sheng, He-Feng Huang
BACKGROUND: Excessive androgen exposure during pregnancy has been suggested to induce diabetic phenotypes in offspring in animal models. The aim of this study was to investigate whether pregestational maternal hyperandrogenism in human influenced the glucose metabolism in offspring via epigenetic memory from mother's oocyte to child's somatic cells. METHODS: Of 1782 reproductive-aged women detected pregestational serum androgen, 1406 were pregnant between 2005 and 2010...
January 11, 2017: EBioMedicine
keyword
keyword
48644
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"