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Yi Shen, Sheng Zhang, Xulin Wang, Yuanyuan Wang, Jian Zhang, Gang Qin, Wenchao Li, Kun Ding, Lei Zhang, Feng Liang
BACKGROUND: Because whether hepatitis B virus (HBV) infection increases the risk of type 2 diabetes mellitus (T2DM) has been a controversial topic, pair-wise and network meta-analyses of published literature were carried out to accurately evaluate the association between different phases of HBV infection and the risk of T2DM. METHODS: A comprehensive literature retrieval was conducted from the Pubmed, Embase, Cochrane Library, Chinese Database to identify epidemiological studies on the association between HBV infection and the risk of T2DM that were published from 1999 to 2015...
October 18, 2016: Liver International: Official Journal of the International Association for the Study of the Liver
Wen-Bin Ou, Minmin Lu, Grant Eilers, Hailong Li, Jiongyan Ding, Xuli Meng, Yuehong Wu, Quan He, Qing Sheng, Hai-Meng Zhou, Jonathan A Fletcher
BACKGROUND: Improved mesothelioma patient survival will require development of novel and more effective pharmacological interventions. TP53 genomic mutations are uncommon in mesothelioma, and recent data indicate that p53 remains functional, and therefore is a potential therapeutic target in these cancers. In addition, the tumour suppressor NF2 is inactivated by genomic mechanisms in more than 80% of mesothelioma, causing upregulation of FAK activity. Because FAK is a negative regulator of p53, NF2 regulation of FAK-p53-MDM2 signalling loops were evaluated...
October 13, 2016: British Journal of Cancer
Lv-Hui Sun, Ding-An Pi, Ling Zhao, Xiu-Ying Wang, Luo-Yi Zhu, De-Sheng Qi, Yu-Lan Liu
Circulating concentration of the essential trace element selenium (Se) was significantly lower in inflammatory disorders. Although Se plays physiological roles mainly through the function of 25 selenoproteins, the response of the selenogenome in immune tissues during inflammatory reactions remains unclear. The objective of this study was to determine the Se retention and selenogenome expression in immune tissues during the lipopolysaccharide (LPS)-induced inflammatory response in porcine. A total of 12 male pigs were randomly divided into two groups and injected with LPS or saline...
October 11, 2016: Biological Trace Element Research
Hua Li, Jia-Sheng Yu, Hua-Sheng Zhang, Yi-Qing Yang, Li-Tian Huang, Ding-Ding Zhang, Chun-Hua Hang
Convincing evidences have proved that apoptosis plays a vital role in the pathogenesis of early and delayed brain injury following subarachnoid hemorrhage (SAH). Recently, a novel caspase-12-mediated apoptotic pathway has been reported to be induced by excess endoplasmic reticulum (ER) stress. Extensive protein damage occurs after SAH, which may trigger ER stress-associated apoptotic pathway. Thus, we hypothesized that caspase-12, as the major molecular marker of this novel apoptotic pathway, may be activated and involved in the pathogenesis of apoptotic injury after SAH...
October 7, 2016: Neurochemical Research
Hao Ding, Qian Yang, Kun Shang, Hailian Lan, Jie Lv, Zhilin Liu, Yang Liu, Lixing Sheng, Yanjun Zeng
BACKGROUND: This study was aimed at developing a myocardial bridge-mural coronary artery simulative device and analyzing the relationship between shear stress on the mural coronary artery and atherosclerosis. METHODS: A myocardial bridge-mural coronary artery simulative device was used to simulate experiments in vitro. In the condition of maintaining any related parameters such as system temperature, average flow rate, and heart rate, we calculated and observed changes in proximal and distal mean values, and oscillatory value of shear stress on the mural coronary artery by regulating the compression level of the myocardial bridge to the mural coronary artery...
October 7, 2016: Cardiology Journal
You-Lin Deng, Shi Tang, Guo-Liang Ding, Ming-Wei Wang, Jie Li, Zeng-Zeng Li, Li Yuan, Rui-Long Sheng
A simple and efficient copper-controlled divergent cyclization of benzamides, which leads to perfluorinated or cyanated isoquinolinediones, is developed. In the presence of AIBN, methacryloyl benzamides with perfluoroalkyl iodides undergo cascade radical addition/cyclization to afford perfluoroinated isoquinolinediones as the major product under metal-free conditions, whereas the use of CuI (10 mol%) is able to redirect the cyclization to yield isoquinolinediones bearing an α-cyano quaternary carbon center...
October 4, 2016: Organic & Biomolecular Chemistry
Yu-Li Jia, Meng Xu, Chang-Wei Dou, Zhi-Kui Liu, Yu-Mo Xue, Bo-Wen Yao, Ling-Long Ding, Kang-Sheng Tu, Xin Zheng, Qing-Guang Liu
Aberrant autophagic processes have been found to have fundamental roles in the pathogenesis of different kinds of tumors, including hepatocellular carcinoma (HCC). P300/CBP-associated factor (PCAF), a histone acetyltransferase (HAT), performs its function by acetylating both histone and non-histone proteins. Our previous studies showed that PCAF was downregulated in HCC tissues and its high expression was significantly associated with patient survival after surgery, serving as a prognostic marker. In this study we found that overexpression of PCAF induced autophagy of HCC cells and its knockdown depressed autophagy...
October 6, 2016: Cell Death & Disease
Ping Sheng, Jiangli Huang, Zhihong Zhang, Dongsheng Wang, Xiaojuan Tian, Jiannan Ding
Degradation of rice straw by cooperative microbial activities is at present the most attractive alternative to fuels and provides a basis for biomass conversion. The use of microbial consortia in the biodegradation of lignocelluloses could reduce problems such as incomplete synergistic enzymes, end-product inhibition, and so on. In this study, a cellulolytic microbial consortium was enriched from the hindgut of Holotrichia parallela larvae via continuous subcultivation (20 subcultures in total) under static conditions...
September 30, 2016: International Journal of Molecular Sciences
Kai-Ting Li, Qing Chen, Da-Wu Wang, Qin-Qin Duan, Si Tian, Juan-Wen He, Yun-Sheng Ou, Ding-Qun Bai
Photodynamic therapy (PDT) is a promising treatment in cancer therapy, with a photosensitizer activated by visible light. Aloe-emodin (AE) is a promising photosensitive agent. In this study, the photosensitizing effects and possible mechanisms of AE-PDT in MG63 cells were evaluated. The efficiency of AE-PDT was analyzed by MTT assay. The mode of cell death was investigated by Hoechst 33,342 staining and flow cytometer. The intracellular distribution of AE was detected with confocal microscopy. The formation of reactive oxygen species (ROS) was detected by DCFH-DA...
October 3, 2016: Cancer Medicine
Lei Ding, Feng Zhang, Ming-Xia Zhao, Xing-Sheng Ren, Qi Chen, Yue-Hua Li, Yu-Ming Kang, Guo-Qing Zhu
Chemical stimulation of white adipose tissue (WAT) causes adipose afferent reflex (AAR) and sympathetic activation. This study is to investigate the effects of AAR on lipolysis and the mechanisms of attenuated lipolysis response to enhanced AAR in obesity. Obesity was caused by high-fat diet for 12 weeks in rats. AAR was induced by injection of capsaicin into inguinal WAT or electrical stimulation of epididymal WAT afferent nerve. AAR caused sympathetic activation, which was enhanced in obesity rats. AAR increased cAMP levels and PKA activity, promoted hormone sensitive lipase (HSL) and perilipin phosphorylation, and increased lipolysis in WAT, which were attenuated in obesity rats...
October 3, 2016: Scientific Reports
Zhi-Gang Huang, Hao-Wen Liu, Zhen-Zhen Yan, Sheng Wang, Lu-Yang Wang, Jiu-Ping Ding
Large-conductance Ca(2+)- and voltage- activated potassium (MaxiK or BK) channels are composed of a pore-forming α subunit (Slo) and four types of auxiliary β subunits or just a pore-forming α subunit. Although multiple N-linked glycosylation sites in the extracellular loop of β subunits have been identified, very little is known about how glycosylation influences the structure and function of BK channels. Using a combination of site-directed mutagenesis, western blot and patch-clamp recordings, we demonstrated that three sites in the extracellular loop of β2 subunit are N-glycosylated (N-X-T/S at N88, N96 and N119)...
October 3, 2016: Channels
Chuan-Xi Wang, Rong Ding, Shu-Tai Jiang, Jin-Shan Tang, Dan Hu, Guo-Dong Chen, Feng Lin, Kui Hong, Xin-Sheng Yao, Hao Gao
Six new 16-membered macrolides with a rare branched octose unit, aldgamycins J-O (1-6), along with two known compounds, swalpamycin B (7) and chalcomycin (8), were isolated from Streptomyces sp. HK-2006-1. Their structures were determined by detailed spectroscopic and X-ray crystallographic analysis. Natural products containing branched sugar units are rare. Aldgaropyranose and decarboxylated aldgaropyranose are branched octoses, specifically aldgarose-type branched octose. Until now, only 11 compounds have been reported to contain an aldgarose-type branched octose...
September 30, 2016: Journal of Natural Products
Hui Ding, Xianhua Gui, Xubo Lin, Ruhua Chen, Tieliang Ma, Yunlu Sheng, Hourong Cai, Yan Fen
The purpose of this study was to examine the MAC30 expression in non-small cell lung cancer and to evaluate its prognostic value on therapeutic response in patients with non-small cell lung cancer receiving postoperative chemotherapy. Among a total of 218 retrospective Chinese patients with non-small cell lung cancer, 164 patients receiving adjuvant chemotherapy were enrolled in this study. Real-time polymerase chain reaction was performed to confirm the expression of MAC30 messenger RNA in 32 cases of non-small cell lung cancer tumors with the corresponding nontumor lung tissues...
September 29, 2016: Technology in Cancer Research & Treatment
YaShu Kuang, Xiaolin Li, Xiaoli Chen, Huimin Sun, Brian Tomlinson, Paul Chan, Liang Zheng, Jinjiang Pi, Sheng Peng, Hong Wu, Xugang Ding, Dingguang Qian, Yixin Shen, Zuoren Yu, Lieying Fan, Ming Chen, Huimin Fan, Zhongmin Liu, Yuzhen Zhang
Lipid levels are increasing in all age groups in the Chinese population, but the use of statin treatment in the elderly is not well documented. We examined serum lipids, statin usage and achievement of lipid goals in 3950 subjects aged ≥65 years. Established CVD was present in 7.77% of participants and increased CVD risk was common. Elevated LDL-C according to CVD risk level was present in 46.70% of all subjects and was more frequent (p < 0.01) than elevated non-HDL-C at 32.58%. With increasing age, LDL-C was unchanged but triglycerides and non-HDL-C decreased and HDL-C increased...
September 30, 2016: Scientific Reports
Wenhui Zhu, Hua Xu, Jing Ma, Jianming Guo, Wei Xue, Baojun Gu, Lu Sheng, Xudong Yao, Fukang Sun, Jian Gong, Weiliang Qiu, Qiang Ding, Haowen Jiang
PURPOSE: The study aimed to evaluate the effects of metformin on insulin, C-peptide and body weight in Chinese men undergoing androgen deprivation therapy (ADT). METHODS: Between March 2013 and June 2014, 62 newly diagnosed patients of prostate cancer (PCa) due to receive ADT were recruited from 7 hospitals in Shanghai. Patients were randomized to respectively receive ADT (n = 31) and ADT + metformin (n = 31) for 6 months. Fasting and postprandial serum levels of insulin and C-peptide, blood glucose, prostate specific antigen, body mass index (BMI) and waist circumference (WC) were measured at the beginning and end of 6-month treatment...
September 30, 2016: Urologia Internationalis
Run-Wei Yang, Ying-Yue Zeng, Wen-Ting Wei, Yan-Mei Cui, Hui-Ying Sun, Yue-Long Cai, Xin-Xin Nian, Yun-Teng Hu, Yu-Ping Quan, Sheng-Lu Jiang, Meng Wang, Ya-Li Zhao, Jun-Feng Qiu, Ming-Xuan Li, Jia-Huan Zhang, Mei-Rong He, Li Liang, Yan-Qing Ding, Wen-Ting Liao
BACKGROUND: Transducin-like enhancer of Split3 (TLE3) serves as a transcriptional corepressor during cell differentiation and shows multiple roles in different kinds of cancers. Recently, TLE3 together with many other genes involved in Wnt/β-catenin pathway were detected hyper-methylated in colorectal cancer (CRC). However, the potential role and the underlying mechanism of TLE3 in CRC progression remain scarce. METHODS: Gene expression profiles were analyzed in The Cancer Genome Atlas (TCGA) microarray dataset of 41 normal colorectal intestine tissues and 465 CRC tissues...
September 27, 2016: Journal of Experimental & Clinical Cancer Research: CR
Tao Zhang, Yun-Long Zhao, Jian-Hua Zhao, Sheng Wang, Yun Jin, Zhong-Qi Chen, Yuan-Yuan Fang, Chen-Lei Hua, Shou-Wei Ding, Hui-Shan Guo
Plant pathogenic fungi represent the largest group of disease-causing agents on crop plants, and are a constant and major threat to agriculture worldwide. Recent studies have shown that engineered production of RNA interference (RNAi)-inducing dsRNA in host plants can trigger specific fungal gene silencing and confer resistance to fungal pathogens(1-7). Although these findings illustrate efficient uptake of host RNAi triggers by pathogenic fungi, it is unknown whether or not such an uptake mechanism has been evolved for a natural biological function in fungus-host interactions...
2016: Nature Plants
Lei Shi, Xiang-Qin Weng, Yan Sheng, Jing Wu, Ming Ding, Xun Cai
Although all-trans retinoic acid (ATRA) is regarded as a prominent example of differentiation therapy, it is not effective for the treatment of other subtypes of acute myeloid leukemia (AML) beyond acute promyelocytic leukemia (APL). Therefore, new strategies need to be explored to extend the efficacy of ATRA-based therapy to non-APL AML patients. In the present study, staurosporine, a protein kinase C (PKC) pan-inhibitor, exhibited synergism with ATRA to promote granulocytic differentiation in poorly ATRA-sensitive U937 cells but not in ATRA unresponsive K562 and Kasumi cells...
September 23, 2016: Oncology Reports
Junlu Sheng, Min Zhang, Yue Xu, Jianyong Yu, Bin Ding
The demand of water-resistant and breathable materials applied to a separation medium and protective garments is steadily increasing. Typical approaches to obtain these functional materials are based on hydrophobic agents and porous substrates with small fiber diameter, tiny pore, and high porosity. However, a fluorinated hydrophobic finishing agent usually employed in providing effective waterproofness is limited with respect to their environmental persistence and toxic potential. Herein, with the aim to keep a balance between the water-resistance and breathability as well as mechanical properties, we fabricate a novel fluoride-free functional membrane by electrospun polyacrylonitrile (PAN) nanofibers modified with polydimethylsiloxane (PDMS)...
October 12, 2016: ACS Applied Materials & Interfaces
Biao Si, Zhao-Sheng Luan, Tong-Jian Wang, Yan-Song Ning, Na Li, Meng Zhu, Zhong-Min Liu, Guang-Hong Ding, Bin Qiao
The aim of the present study was to determine the distribution of lung blood in a modified bilateral Glenn procedure designed in our institute with lung perfusion scintigraphy. Sixteen consecutive patients who underwent modified bilateral Glenn operation from 2011 to 2014 were enrolled in the study. The control group consisted of 7 patients who underwent bidirectional Glenn shunt. Radionuclide lung perfusion scintigraphy was performed using Tc-99m-macro aggregated albumin (MAA) in all patients. For the patients in modified bilateral Glenn group, the time at which the radioactivity accumulation peaked did not differ significantly between the right and left lung field (t = 0...
September 2016: Medicine (Baltimore)
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