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https://www.readbyqxmd.com/read/28938693/the-regulation-of-immune-cells-by-lactobacilli-a-potential-therapeutic-target-for-anti-atherosclerosis-therapy
#1
REVIEW
Ya-Hui Ding, Lin-Yan Qian, Jie Pang, Jing-Yang Lin, Qiang Xu, Li-Hong Wang, Dong-Sheng Huang, Hai Zou
Atherosclerosis is an inflammatory disease regulated by several immune cells including lymphocytes, macrophages and dendritic cells. Gut probiotic bacteria like Lactobacilli have been shown immunomodificatory effects in the progression of atherogenesis. Some Lactobacillus stains can upregulate the activity of regulatory T-lymphocytes, suppress T-lymphocyte helper (Th) cells Th1, Th17, alter the Th1/Th2 ratio, influence the subsets ratio of M1/M2 macrophages, inhibit foam cell formation by suppressing macrophage phagocytosis of oxidized low-density lipoprotein, block the activation of the immune system with dendritic cells, which are expected to suppress the atherosclerosis-related inflammation...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28937853/assessment-of-microvascular-invasion-of-hepatocellular-carcinoma-with-diffusion-kurtosis-imaging
#2
Wen-Tao Wang, Li Yang, Zhao-Xia Yang, Xin-Xing Hu, Ying Ding, Xu Yan, Cai-Xia Fu, Robert Grimm, Meng-Su Zeng, Sheng-Xiang Rao
Purpose To evaluate the potential role of diffusion kurtosis imaging and conventional magnetic resonance (MR) imaging findings including standard monoexponential model of diffusion-weighted imaging and morphologic features for preoperative prediction of microvascular invasion (MVI) of hepatocellular carcinoma (HCC). Materials and Methods Institutional review board approval and written informed consent were obtained. Between September 2015 and November 2016, 84 patients (median age, 54 years; range, 29-79 years) with 92 histopathologically confirmed HCCs (40 MVI-positive lesions and 52 MVI-negative lesions) were analyzed...
September 22, 2017: Radiology
https://www.readbyqxmd.com/read/28933203/in-vivo-antitumor-effect-of-endostatin-loaded-chitosan-nanoparticles-combined-with-paclitaxel-on-lewis-lung-carcinoma
#3
Fang Xie, Rui-Lin Ding, Wen-Feng He, Zong-Jun-Lin Liu, Shao-Zhi Fu, Jing-Bo Wu, Ling-Lin Yang, Sheng Lin, Qing-Lian Wen
The purpose of this study was to prepare endostatin-loaded chitosan nanoparticles (ES-NPs) and evaluate their antitumor effect when combined with paclitaxel (PTX) on Lewis lung carcinoma (LLC) mouse xenografts. ES-NPs were prepared by ionic cross-linking. Characterization of the ES-NPs included size distribution, drug-loading efficiency (DL), and encapsulation efficiency (EE). An in vitro release test was also used to determine the release behavior of the ES-NPs. A subcutaneous LC xenograft model of C57BL/6J mice was established...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28930552/microrna-181a-inhibits-autophagy-by-targeting-atg5-in-hepatocellular-carcinoma
#4
Jun Yang, Youzhao He, Niankuan Zhai, Sheng Ding, Jianping Li, Zhihai Peng
Available evidence suggests that autophagy may serve as a tumor suppressor in cases of chronic liver disease and liver cirrhosis and that autophagic deficiency may lead to hepatocellular carcinoma (HCC). Recent studies suggested that the development of several tumor types could be regulated by microRNA-181a. However, the role of miR-181a in the autophagy of HCC remains unclear. In this study, we aimed to investigate the role of miR-181a in the autophagy of HCC. We found that the mRNA expression of miR-181a is higher but the level of autophagy is lower in human HCC compared to normal liver tissue...
January 1, 2018: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/28929287/performance-evaluation-and-microbial-community-analysis-of-the-function-and-fate-of-ammonia-in-a-sulfate-reducing-egsb-reactor
#5
Depeng Wang, Bo Liu, Xinchun Ding, Xinbo Sun, Zi Liang, Shixiong Sheng, Lingfeng Du
Ammonia is widely distributed in sulfate-reducing bioreactor dealing with sulfate wastewater, which shows potential effect on the metabolic pathway of sulfate and ammonia. This study investigates the sulfate-reducing efficiency and microbial community composition in the sulfate-reducing EGSB reactor with the increasing ammonia loading. Results indicated that, compared with low ammonia loading (166-666 mg/L), the sulfate and organic matter removal efficiencies were improved gradually with the appropriate ammonia loading (1000-2000 mg/L), which increased from 63...
September 19, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28927469/genetic-diversity-of-haemonchus-contortus-isolated-from-sympatric-wild-blue-sheep-pseudois-nayaur-and-sheep-in-helan-mountains-china
#6
Dong-Dong Shen, Ji-Fei Wang, Dan-Yu Zhang, Zhi-Wei Peng, Tian-Yun Yang, Zhao-Ding Wang, Dwight D Bowman, Zhi-Jun Hou, Zhen-Sheng Liu
BACKGROUND: Haemonchus contortus is known among parasitic nematodes as one of the major veterinary pathogens of small ruminants and results in great economic losses worldwide. Human activities, such as the sympatric grazing of wild with domestic animals, may place susceptible wildlife hosts at risk of increased prevalence and infection intensity with this common small ruminant parasite. Studies on phylogenetic factors of H. contortus should assist in defining the amount of the impact of anthropogenic factors on the extent of sharing of agents such as this nematode between domestic animals and wildlife...
September 19, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28918321/extending-donor-size-in-d-a-%C3%AF-a-organic-dye-for-dye-sensitized-solar-cells-anti-aggregation-and-improving-electron-injection
#7
Yuan-Chun Hu, Wei-Lu Ding, Xing-Liang Peng, Ze-Sheng Li
We have theoretically designed two D-A-π-A dyes 3 and 4 based on the efficient references 1 and 2 by introducing an extra electron donor unit (D2). Via calculating the electronic structures of isolated dyes, we obtain that dyes 3 and 4 possess stronger light-harvesting efficiency imparted by the fluorescence energy transfer of D2 part, maintain comparable lifetime of excited states, and shorten the electron injection time significantly with regard to 1 and 2. Meanwhile, dye 3 positively shifts the edge of virtual states of TiO2 in a larger extent compared to its counterparts...
September 8, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/28902362/histone-lysine-methylation-and-congenital-heart-disease-from-bench-to-bedside-review
#8
Xin Yi, Xuejun Jiang, Xiaoyan Li, Ding-Sheng Jiang
Histone post-translational modifications (PTM) as one of the key epigenetic regulatory mechanisms that plays critical role in various biological processes, including regulating chromatin structure dynamics and gene expression. Histone lysine methyltransferase contributes to the establishment and maintenance of differential histone methylation status, which can recognize histone methylated sites and build an association between these modifications and their downstream processes. Recently, it was found that abnormalities in the histone lysine methylation level or pattern may lead to the occurrence of many types of cardiovascular diseases, such as congenital heart disease (CHD)...
October 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28888960/complete-genome-sequence-of-endophyte-bacillus-flexus-klbmp-4941-reveals-its-plant-growth-promotion-mechanism-and-genetic-basis-for-salt-tolerance
#9
Tian-Tian Wang, Peng Ding, Pan Chen, Ke Xing, Juan-Luan Bai, Wen Wan, Ji-Hong Jiang, Sheng Qin
Bacillus flexus KLBMP 4941 is a halotolerant endophyte isolated from the halophyte Limonium sinense. This strain can improve host seedling growth under salt stress conditions. We here report the complete genome information of endophyte KLBMP 4941. It has a circular chromosome and two plasmids for a total genome 4,104,242 bp in size with a G+C content of 38.09%. Genes related to plant growth promotion (PGP), such as those associated with nitrogen fixation, siderophore, spermidine, and acetoin synthesis were found in the KLBMP 4941 genome...
September 6, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/28884622/ex-vivo-and-in-vivo-noninvasive-imaging-of-epidermal-growth-factor-receptor-inhibition-on-colon-tumorigenesis-using-activatable-near-infrared-fluorescent-probes
#10
Shengli Ding, Randall E Blue, Emily Moorefield, Hong Yuan, Pauline K Lund
BACKGROUND: Near-infrared fluorescence (NIRF) imaging combined with enzyme-activatable NIRF probes has yielded promising results in cancer detection. OBJECTIVE: To test whether 3-dimensional (3-D) noninvasive in vivo NIRF imaging can detect effects of epidermal growth factor receptor (EGFR) inhibitor on both polypoid and flat tumor load in azoxymethane (AOM)-induced colon tumors or tumors in Apc(Min/+) mice. METHODS: The AOM-injected KK-HIJ mice received EGFR inhibitor diet or chow diet...
January 2017: Molecular Imaging
https://www.readbyqxmd.com/read/28882800/c1r-and-c1s-from-nile-tilapia-oreochromis-niloticus-molecular-characterization-transcriptional-profiling-upon-bacterial-and-ifn-%C3%AE-inductions-and-potential-role-in-response-to-bacterial-infection
#11
Xiaofang Zhong, Meng Chen, Mingmei Ding, Meiqi Zhong, Bingxi Li, Yuhong Wang, Shengli Fu, Xiaoxue Yin, Zheng Guo, Jianmin Ye
The complement components C1r and C1s play a vital role in immunity with the activation of C1 complex in the classical complement pathway against pathogen infection. In this study, Nile tilapia (Oreochromis niloticus) C1r and C1s orthologs (OnC1r and OnC1s) were identified and characterized. The cDNA of OnC1r and OnC1s ORFs consisted of 1902 bp and 2100 bp of nucleotide sequence encoding polypeptides of 633 and 699 amino acids, respectively. The deduced OnC1r and OnC1s proteins both possessed CUB, EGF, CCP and SP domains, which were significantly homology to teleost...
September 5, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28881850/transforming-growth-factor-%C3%AE-a-potential-biomarker-and-therapeutic-target-of-ventricular-remodeling
#12
REVIEW
Yuan Ma, Hai Zou, Xing-Xing Zhu, Jie Pang, Qiang Xu, Qin-Yang Jin, Ya-Hui Ding, Bing Zhou, Dong-Sheng Huang
Transforming growth factor β (TGF-β) is a multifunctional cytokine that is synthesized by many types of cells and regulates the cell cycle. Increasing evidence has led to TGF-β receiving increased and deserved attention in recent years because it may play a potentially novel and critical role in the development and progression of myocardial fibrosis and the subsequent progress of ventricular remodeling (VR). Numerous studies have highlighted a crucial role of TGF-β in VR and suggest potential therapeutic targets of the TGF-β signaling pathways for VR...
August 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28876197/the-impact-of-flt3-mutations-on-treatment-response-and-survival-in-chinese-de%C3%A2-novo-aml-patients
#13
Qiao-Cheng Qiu, Chao Wang, Xie-Bing Bao, Jing Yang, Hong-Jie Shen, Zi-Xuan Ding, Hong Liu, Jun He, Hong Yao, Su-Ning Chen, Zheng Li, Sheng-Li Xue, Song-Bai Liu
OBJECTIVE: Two distinct forms of FMS-like tyrosine kinase 3 (FLT3) mutations, internal tandem duplication (ITD) in the juxtamembrane domain and point mutation within the activation loop of the tyrosine kinase domain (TKD), have been identified in considerable number of patients with AML. This study was aimed to analyze the impacts of these mutations on clinical outcomes, and assess the efficacy of different therapeutic regimens (allo-HSCT, sorafenib, or conventional chemotherapy) for AML patients with FLT3 mutations after the standard induction therapy...
September 6, 2017: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/28874583/smad7-enables-stat3-activation-and-promotes-pluripotency-independent-of-tgf-%C3%AE-signaling
#14
Yi Yu, Shuchen Gu, Wenjian Li, Chuang Sun, Fenfang Chen, Mu Xiao, Lei Wang, Dewei Xu, Ye Li, Chen Ding, Zongping Xia, Yi Li, Sheng Ye, Pinglong Xu, Bin Zhao, Jun Qin, Ye-Guang Chen, Xia Lin, Xin-Hua Feng
Smad7 is a negative feedback product of TGF-β superfamily signaling and fine tunes a plethora of pleiotropic responses induced by TGF-β ligands. However, its noncanonical functions independent of TGF-β signaling remain to be elucidated. Here, we show that Smad7 activates signal transducers and activators of transcription 3 (STAT3) signaling in maintaining mouse embryonic stem cell pluripotency in a manner independent of the TGF-β receptors, yet dependent on the leukemia inhibitory factor (LIF) coreceptor glycoprotein 130 (gp130)...
September 5, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28871395/interactome-analysis-of-transcriptional-coactivator-multiprotein-bridging-factor-1-unveils-a-yeast-ap-1-like-transcription-factor-involved-in-oxidation-tolerance-of-mycopathogen-beauveria-bassiana
#15
Xin-Ling Chu, Wei-Xia Dong, Jin-Li Ding, Ming-Guang Feng, Sheng-Hua Ying
Oxidation tolerance is an important determinant to predict the virulence and biocontrol potential of Beauveria bassiana, a well-known entomopathogenic fungus. As a transcriptional coactivator, multiprotein bridging factor 1 mediates the activity of transcription factor in diverse physiological processes, and its homolog in B. bassiana (BbMBF1) contributes to fungal oxidation tolerance. In this study, the BbMBF1-interactomes under oxidative stress and normal growth condition were deciphered by mass spectrometry integrated with the immunoprecipitation...
September 4, 2017: Current Genetics
https://www.readbyqxmd.com/read/28870734/curcusone-c-induces-telomeric-dna-damage-response-in-cancer-cells-through-inhibition-of-telomeric-repeat-factor-2
#16
Mingxue Wang, Jiaojiao Cao, Jian-Yong Zhu, Jun Qiu, Yan Zhang, Bing Shu, Tian-Miao Ou, Jia-Heng Tan, Lian-Quan Gu, Zhi-Shu Huang, Sheng Yin, Ding Li
Telomeric repeat factor 2 (known as TRF2 or TERF2) is a key component of telomere protection protein complex named as Shelterin. TRF2 helps the folding of telomere to form T-loop structure and the suppression of ATM-dependent DNA damage response activation. TRF2 has been recognized as a potentially new therapeutic target for cancer treatment. In our routine screening of small molecule libraries, we found that Curcusone C had significant effect in disrupting the binding between TRF2 and telomeric DNA, with potent antitumor activity against cancer cells...
September 11, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28870649/lipopolysaccharide-impairs-permeability-of-pulmonary-microvascular-endothelial-cells-via-connexin40
#17
Hua-Song Zhou, Meng Li, Bing-Dong Sui, Lei Wei, Rui Hou, Wen-Sheng Chen, Qiang Li, Sheng-Hui Bi, Jin-Zhou Zhang, Ding-Hua Yi
The endotoxin lipopolysaccharide (LPS)-induced pulmonary endothelial barrier disruption is a key pathogenesis of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). However, the molecular mechanisms underlying LPS-impaired permeability of pulmonary microvascular endothelial cells (PMVECs) are not fully understood. Gap junctions, particularly Connexin40 (Cx40), are necessary for the maintenance of normal vascular function. In this study, we for the first time investigated the role of Cx40 in LPS-impaired permeability of PMVECs and provided potential therapeutic approaches based on mechanistic findings of Cx40 regulation by LPS stimuli...
September 1, 2017: Microvascular Research
https://www.readbyqxmd.com/read/28866877/occurrence-and-source-effect-of-novel-brominated-flame-retardants-nbfrs-in-soils-from-five-asian-countries-and-its-relationship-with-pbdes
#18
Wen-Long Li, Wan-Li Ma, Zifeng Zhang, Liyan Liu, Wei-Wei Song, Hongliang Jia, Yong-Sheng Ding, Haruhiko Nakata, Nguyen Hung Minh, Ravindra Kumar Sinha, Hyo-Bang Moon, Kurunthachalam Kannan, Ed Sverko, Yi-Fan Li
This paper presents the first comprehensive survey of 19 novel brominated flame retardants (NBFRs) in soil samples collected across five Asian countries. High variability in concentrations of all NBFRs was found in soils with the geometric mean (GM) values ranging from 0.50 ng/g dry weight (dw) in Vietnam to 540 ng/g dw in the vicinity of a BFR-manufactory in China. In urban/rural/background locations, the GM concentrations of ∑19NBFRs decreased in the order of Japan > South Korea > China > India > Vietnam...
September 3, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28866459/functional-modification-of-breathable-polyacrylonitrile-polyurethane-tio2-nanofibrous-membranes-with-robust-ultraviolet-resistant-and-waterproof-performance
#19
Yue Xu, Junlu Sheng, Xia Yin, Jianyong Yu, Bin Ding
Exploiting high-added-value textiles equipped with multiple functionalities like ultraviolet (UV) resistance, waterproofness, and thermal-moisture comfort is facing tremendous demand by a more discerning consumer market. However, the major challenge is to realize the equilibrium among the multifunction. Herein, a new attempt of fabricating superhydrophobic electrospun polyacrylonitrile (PAN)/polyurethane (PU)/titanium dioxide (TiO2) nanofibrous membranes has been tried, and the membranes exhibited multifunction of UV resistance, waterproofness and breathability by coating modification with 2-hydroxy-4-n-octoxybenzophenone (UV531) and fluorinated acrylic copolymer (FAC)...
August 18, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28865746/rapid-targeted-next-generation-sequencing-platform-for-molecular-screening-and-clinical-genotyping-in-subjects-with-hemoglobinopathies
#20
Xuan Shang, Zhiyu Peng, Yuhua Ye, Asan, Xinhua Zhang, Yan Chen, Baosheng Zhu, Wangwei Cai, Shaoke Chen, Ren Cai, Xiaoling Guo, Chonglin Zhang, Yuqiu Zhou, Shuodan Huang, Yanhui Liu, Biyan Chen, Shanhuo Yan, Yajun Chen, Hongmei Ding, Xiaolin Yin, Liusong Wu, Jing He, Dongai Huang, Sheng He, Tizhen Yan, Xin Fan, Yuehong Zhou, Xiaofeng Wei, Sumin Zhao, Decheng Cai, Fengyu Guo, Qianqian Zhang, Yun Li, Xuelian Zhang, Haorong Lu, Huajie Huang, Junfu Guo, Fei Zhu, Yuan Yuan, Li Zhang, Na Liu, Zhiming Li, Hui Jiang, Qiang Zhang, Yijia Zhang, Wan Khairunnisa Wan Juhari, Sarifah Hanafi, Wanjun Zhou, Fu Xiong, Huanming Yang, Jian Wang, Bin Alwi Zilfalil, Ming Qi, Yaping Yang, Ye Yin, Mao Mao, Xiangmin Xu
Hemoglobinopathies are among the most common autosomal-recessive disorders worldwide. A comprehensive next-generation sequencing (NGS) test would greatly facilitate screening and diagnosis of these disorders. An NGS panel targeting the coding regions of hemoglobin genes and four modifier genes was designed. We validated the assay by using 2522 subjects affected with hemoglobinopathies and applied it to carrier testing in a cohort of 10,111 couples who were also screened through traditional methods. In the clinical genotyping analysis of 1182 β-thalassemia subjects, we identified a group of additional variants that can be used for accurate diagnosis...
August 17, 2017: EBioMedicine
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