keyword
https://read.qxmd.com/read/38523459/the-woundosome-concept-and-its-impact-on-procedural-outcomes-in-patients-with-chronic-limb-threatening-ischemia
#1
EDITORIAL
Lorenzo Patrone, Edoardo Pasqui, Michael S Conte, Alik Farber, Roberto Ferraresi, Matthew Menard, Joseph L Mills, John Rundback, Peter Schneider, August Ysa, Kumar Abhishek, George L Adams, Naseer Ahmad, Irfan Ahmed, Vlad A Alexandrescu, Max Amor, David Alper, Martin Andrassy, Christopher Attinger, Andy Baadh, Hashem Barakat, Lukla Biasi, Theodosios Bisdas, Zagum Bhatti, Erwin Blessing, Marc P Bonaca, Stefano Bonvini, Michel Bosiers, Andrew W Bradbury, Robert Beasley, Christian-Alexander Behrendt, Marianne Brodmann, Gonzalo Cabral, Roberto Cancellieri, Andrea Casini, Venita Chandra, Emiliano Chisci, Omar Chohan, Edward T C Choke, Patrick F S Chong, Giacomo Clerici, Raphael Coscas, Mary Costantino, Luca Dalla Paola, Sabeen Dand, Robert S M Davies, Mario D'Oria, Athanasios Diamantopoulos, Sebastian Debus, Koen Deloose, Costantino Del Giudice, Gianmarco de Donato, Brian De Rubertis, Jean Paul De Vries, Nuno V Dias, Larry Diaz-Sandoval, Florian Dick, Konstantinos Donas, Anahita Dua, Fabrizio Fanelli, Stefano Fazzini, Mazin Foteh, Roberto Gandini, Mauro Gargiulo, Luca Garriboli, Elizabeth A Genovese, Edward Gifford, Yann Goueffic, Peter Goverde, Prem Chand Gupta, Robert Hinchliffe, Andrew Holden, Kim C Houlind, Dominic Pj Howard, Bella Huasen, Giacomo Isernia, Konstantinos Katsanos, Barry Katzen, Philippe Kolh, Igor Koncar, Grigorios Korosoglou, Prakash Krishnan, Thomas Kroencke, Miltiadis Krokidis, Arun Kumarasamy, Paul Hayes, Osamu Iida, Enrique Alejandre Lafont, Ralf Langhoff, Alexandre Lecis, Mark Lessne, Hady Lichaa, Michael Lichtenberg, Marta Lobato, Alice Lopes, Giorgio Loreni, Pierleone Lucatelli, Sreekumar Madassery, Lieven Maene, Marco Manzi, Martin Maresch, Jay Santhosh Mathews, James McCaslin, Antonio Micari, Stefano Michelagnoli, Bruno Migliara, Robert Morgan, Luis Morelli, Daniele Morosetti, Nicolas Mouawad, Paul Moxey, Stefan Müller-Hülsbeck, Jihad Mustapha, Tatsuya Nakama, Bahaa Nasr, Zola N'dandu, Richard Neville, Elias Noory, Joakim Nordanstig, Katariina Noronen, Luis Mariano Palena, Gianbattista Parlani, Ashish S Patel, Parag Patel, Rafiuddin Patel, Sanjay Patel, Costantino Pena, Drazen Perkov, Mark Portou, Giovanni Pratesi, Christos Rammos, Jim Reekers, Vicente Riambau, Trisha Roy, Kenneth Rosenfield, Maria Antonella Ruffino, Fadi Saab, Athanasios Saratzis, Paolo Sbarzaglia, Andrej Schmidt, Eric Secemsky, Michael Siah, Henrik Sillesen, Gioele Simonte, Marc Sirvent, Jill Sommerset, Sabine Steiner, Ahmed Sakr, Dierk Scheinert, Mehdi Shishebor, Stavros Spiliopoulos, Alessio Spinelli, Konstantinos Stravoulakis, Gergana Taneva, Desarom Teso, Joerg Tessarek, Selva Theivacumar, Anish Thomas, Shannon Thomas, Narayan Thulasidasan, Giovanni Torsello, Ramesh Tripathi, Nicola Troisi, Srini Tummala, Venkat Tummala, Christopher Twine, Raman Uberoi, Alessandro Ucci, Domenico Valenti, Jos van den Berg, Daniel van den Heuvel, Isabelle Van Herzeele, Ramon Varcoe, Melina Vega de Ceniga, Frank J Veith, Maarit Venermo, Badri Vijaynagar, Sanjiv Virdee, Conrad Von Stempel, Michiel T Voûte, Kak Khee Yeung, Thomas Zeller, Hany Zayed, Miguel Montero Baker
No abstract text is available yet for this article.
March 25, 2024: Journal of Endovascular Therapy
https://read.qxmd.com/read/38500737/pulmonary-hypertension-intensification-and-personalization-of-combination-rx-phoenix-a-phase-iv-randomized-trial-for-the-evaluation-of-dose-response-and-clinical-efficacy-of-riociguat-and-selexipag-using-implanted-technologies
#2
JOURNAL ARTICLE
Frances Varian, Jennifer Dick, Christian Battersby, Stefan Roman, Jenna Ablott, Lisa Watson, Sarah Binmahfooz, Hamza Zafar, Gerry Colgan, John Cannon, Jay Suntharalingam, Jim Lordan, Luke Howard, Colm McCabe, John Wort, Laura Price, Colin Church, Neil Hamilton, Iain Armstrong, Abdul Hameed, Judith Hurdman, Charlie Elliot, Robin Condliffe, Martin Wilkins, Alastair Webb, David Adlam, Ray L Benza, Kazem Rahimi, Mohadeseh Shojaei-Shahrokhabadi, Nan X Lin, James M S Wason, Alasdair McIntosh, Alex McConnachie, Jennifer T Middleton, Roger Thompson, David G Kiely, Mark Toshner, Alexander Rothman
Approved therapies for the treatment of patients with pulmonary arterial hypertension (PAH) mediate pulmonary vascular vasodilatation by targeting distinct biological pathways. International guidelines recommend that patients with an inadequate response to dual therapy with a phosphodiesterase type-5 inhibitor (PDE5i) and endothelin receptor antagonist (ERA), are recommended to either intensify oral therapy by adding a selective prostacyclin receptor (IP) agonist (selexipag), or switching from PDE5i to a soluble guanylate-cyclase stimulator (sGCS; riociguat)...
January 2024: Pulmonary Circulation
https://read.qxmd.com/read/38442160/timed-receptor-tyrosine-kinase-signaling-couples-the-central-and-a-peripheral-circadian-clock-in-drosophila
#3
JOURNAL ARTICLE
Javier Cavieres-Lepe, Emad Amini, Maia Zabel, Dick R Nässel, Ralf Stanewsky, Christian Wegener, John Ewer
Circadian clocks impose daily periodicities to behavior, physiology, and metabolism. This control is mediated by a central clock and by peripheral clocks, which are synchronized to provide the organism with a unified time through mechanisms that are not fully understood. Here, we characterized in Drosophila the cellular and molecular mechanisms involved in coupling the central clock and the peripheral clock located in the prothoracic gland (PG), which together control the circadian rhythm of emergence of adult flies...
March 12, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38405959/clinical-genomic-and-neurophysiological-correlates-of-lifetime-suicide-attempts-among-individuals-with-alcohol-dependence
#4
Peter Barr, Zoe Neale, Chris Chatzinakos, Jessica Schulman, Niamh Mullins, Jian Zhang, David Chorlian, Chella Kamarajan, Sivan Kinreich, Ashwini Pandey, Gayathri Pandey, Stacey Saenz de Viteri, Laura Acion, Lance Bauer, Kathleen Bucholz, Grace Chan, Danielle Dick, Howard Edenberg, Tatiana Foroud, Alison Goate, Victor Hesselbrock, Emma Johnson, John Kramer, Dongbing Lai, Martin Plawecki, Jessica Salvatore, Leah Wetherill, Arpana Agrawal, Bernice Porjesz, Jacquelyn Meyers
Research has identified clinical, genomic, and neurophysiological markers associated with suicide attempts (SA) among individuals with psychiatric illness. However, there is limited research among those with an alcohol use disorder (AUD), despite their disproportionately higher rates of SA. We examined lifetime SA in 4,068 individuals with DSM-IV alcohol dependence from the Collaborative Study on the Genetics of Alcoholism (23% lifetime suicide attempt; 53% female; 17% Admixed African American ancestries; mean age: 38)...
February 9, 2024: Research Square
https://read.qxmd.com/read/38405837/metformin-reduces-the-clonal-fitness-of-dnmt3ar878h-hematopoietic-stem-and-progenitor-cells-by-reversing-their-aberrant-metabolic-and-epigenetic-state
#5
Steven Chan, Mohsen Hosseini, Veronique Voisin, Ali Chegini, Angelica Varesi, Severine Cathelin, Dhanoop Manikoth Ayyathan, Alex Liu, Yitong Yang, Vivian Wang, Abdula Maher, Eric Grignano, Julie Haines, Angelo D'Alessandro, Kira Young, Yiyan Wu, Martina Fiumara, Samuele Ferrari, Luigi Naldini, Federico Gaiti, Shraddha Pai, Aaron Schimmer, Gary Bader, John Dick, Stephanie Z Xie, Jennifer Trowbridge
Clonal hematopoiesis (CH) arises when a hematopoietic stem cell (HSC) acquires a mutation that confers a competitive advantage over wild-type (WT) HSCs, resulting in its clonal expansion. Individuals with CH are at an increased risk of developing hematologic neoplasms and a range of age-related inflammatory illnesses1-3. Therapeutic interventions that suppress the expansion of mutant HSCs have the potential to prevent these CH-related illnesses; however, such interventions have not yet been identified. The most common CH driver mutations are in the DNA methyltransferase 3 alpha (DNMT3A) gene with arginine 882 (R882) being a mutation hotspot...
February 6, 2024: Research Square
https://read.qxmd.com/read/38391841/quality-of-life-and-treatment-modalities-in-patients-with-interstitial-cystitis-the-patients-perspective
#6
JOURNAL ARTICLE
Charlotte van Ginkel, Frank Martens, Mathilde Scholtes, John Heesakkers, Dick A W Janssen
BACKGROUND: Quality of life (QoL)-based outcomes are hardly incorporated into interstitial cystitis/bladder pain syndrome (IC/BPS) guidelines, because studies are limited and outdated. Therefore, guidelines might not reflect the current clinical situation accurately. Secondly, guidelines suggest using a multimodal approach for BPS/IC management, but data on the patient-perceived efficacy of these therapies are limited. The aim of this study is to investigate the perception of IC/BPS patients of their QoL, to determine which treatments they have received, and to examine how they evaluate the efficacy of these various (alternative) therapies...
February 13, 2024: Healthcare (Basel, Switzerland)
https://read.qxmd.com/read/38351049/u-s-cereal-rye-winter-cover-crop-growth-database
#7
JOURNAL ARTICLE
Alexandra M Huddell, Resham Thapa, Guillermo S Marcillo, Lori J Abendroth, Victoria J Ackroyd, Shalamar D Armstrong, Gautam Asmita, Muthukumar V Bagavathiannan, Kipling S Balkcom, Andrea Basche, Shawn Beam, Kevin Bradley, Lucas Pecci Canisares, Heather Darby, Adam S Davis, Pratap Devkota, Warren A Dick, Jeffery A Evans, Wesley J Everman, Tauana Ferreira de Almeida, Michael L Flessner, Lisa M Fultz, Stefan Gailans, Masoud Hashemi, Joseph Haymaker, Matthew J Helmers, Nicholas Jordan, Thomas C Kaspar, Quirine M Ketterings, Eileen Kladivko, Alexandra Kravchenko, Eugene P Law, Lauren Lazaro, Ramon G Leon, Jeffrey Liebert, John Lindquist, Kristen Loria, Jodie M McVane, Jarrod O Miller, Michael J Mulvaney, Nsalambi V Nkongolo, Jason K Norsworthy, Binaya Parajuli, Christopher Pelzer, Cara Peterson, Hanna Poffenbarger, Pratima Poudel, Mark S Reiter, Matt Ruark, Matthew R Ryan, Spencer Samuelson, John E Sawyer, Sarah Seehaver, Lovreet S Shergill, Yogendra Raj Upadhyaya, Mark VanGessel, Ashley L Waggoner, John M Wallace, Samantha Wells, Charles White, Bethany Wolters, Alex Woodley, Rongzhong Ye, Eric Youngerman, Brian A Needelman, Steven B Mirsky
Winter cover crop performance metrics (i.e., vegetative biomass quantity and quality) affect ecosystem services provisions, but they vary widely due to differences in agronomic practices, soil properties, and climate. Cereal rye (Secale cereale) is the most common winter cover crop in the United States due to its winter hardiness, low seed cost, and high biomass production. We compiled data on cereal rye winter cover crop performance metrics, agronomic practices, and soil properties across the eastern half of the United States...
February 13, 2024: Scientific Data
https://read.qxmd.com/read/38321977/pelvic-pain-syndromes
#8
JOURNAL ARTICLE
John Heesakkers, Dick Janssen
No abstract text is available yet for this article.
March 1, 2024: Current Opinion in Urology
https://read.qxmd.com/read/38299059/ati-1777-a-topical-jak1-3-inhibitor-may-benefit-atopic-dermatitis-without-systemic-drug-exposure-results-from-preclinical-development-and-phase-2a-randomized-control-study-ati-1777-ad-201
#9
JOURNAL ARTICLE
Paul Changelian, Canxin Xu, Steve Mnich, Heidi Hope, Kourtney Kostecki, Jeff Hirsch, Chin-Yi Loh, David Anderson, James Blinn, Susan Hockerman, Evan Dick, Walter Smith, Joseph Monahan, Tooraj Raoof, Seth Forman, David Burt, Brad Barnes, David Gordon, Neal Walker, John Sudzina, Stephen Tucker, Jon Jacobsen
INTRODUCTION: Atopic dermatitis, a chronic, pruritic skin disease, affects 10-30% of children and up to 14% of adults in developed countries. ATI-1777, a potent and selective Jak1/3 inhibitor, was designed with multiple sites of metabolism to deliver local efficacy in the skin and limit systemic exposure. In preclinical studies, ATI-1777 selectively inhibited Jak1/3 with limited systemic exposure and without any adverse effects. PRIMARY OBJECTIVE: The primary goal of this study was to assess the preliminary clinical efficacy of ATI-1777 topical solution in adults with moderate or severe atopic dermatitis...
March 2024: JID innovations
https://read.qxmd.com/read/38234771/precise-single-cell-transcriptomic-mapping-of-normal-and-leukemic-cell-states-reveals-unconventional-lineage-priming-in-acute-myeloid-leukemia
#10
Andy G X Zeng, Ilaria Iacobucci, Sayyam Shah, Amanda Mitchell, Gordon Wong, Suraj Bansal, Qingsong Gao, Hyerin Kim, James A Kennedy, Mark D Minden, Torsten Haferlach, Charles G Mullighan, John E Dick
Initial classification of acute leukemia involves the assignment of blasts to cell states within the hematopoietic hierarchy based on morphological and immunophenotypic features. Yet, these traditional classification approaches lack precision, especially at the level of immature blasts. Single-cell RNA-sequencing (scRNA-seq) enables precise determination of cell state using thousands of markers, thus providing an opportunity to re-examine present-day classification schemes of acute leukemia. Here, we developed a detailed reference map of human bone marrow hematopoiesis from 263,519 single-cell transcriptomes spanning 55 cellular states...
December 27, 2023: bioRxiv
https://read.qxmd.com/read/38195980/smaller-total-and-subregional-cerebellar-volumes-in-posttraumatic-stress-disorder-a-mega-analysis-by-the-enigma-pgc-ptsd-workgroup
#11
JOURNAL ARTICLE
Ashley A Huggins, C Lexi Baird, Melvin Briggs, Sarah Laskowitz, Ahmed Hussain, Samar Fouda, Courtney Haswell, Delin Sun, Lauren E Salminen, Neda Jahanshad, Sophia I Thomopoulos, Dick J Veltman, Jessie L Frijling, Miranda Olff, Mirjam van Zuiden, Saskia B J Koch, Laura Nawjin, Li Wang, Ye Zhu, Gen Li, Dan J Stein, Jonathan Ipser, Soraya Seedat, Stefan du Plessis, Leigh L van den Heuvel, Benjamin Suarez-Jimenez, Xi Zhu, Yoojean Kim, Xiaofu He, Sigal Zilcha-Mano, Amit Lazarov, Yuval Neria, Jennifer S Stevens, Kerry J Ressler, Tanja Jovanovic, Sanne J H van Rooij, Negar Fani, Anna R Hudson, Sven C Mueller, Anika Sierk, Antje Manthey, Henrik Walter, Judith K Daniels, Christian Schmahl, Julia I Herzog, Pavel Říha, Ivan Rektor, Lauren A M Lebois, Milissa L Kaufman, Elizabeth A Olson, Justin T Baker, Isabelle M Rosso, Anthony P King, Isreal Liberzon, Mike Angstadt, Nicholas D Davenport, Scott R Sponheim, Seth G Disner, Thomas Straube, David Hofmann, Rongfeng Qi, Guang Ming Lu, Lee A Baugh, Gina L Forster, Raluca M Simons, Jeffrey S Simons, Vincent A Magnotta, Kelene A Fercho, Adi Maron-Katz, Amit Etkin, Andrew S Cotton, Erin N O'Leary, Hong Xie, Xin Wang, Yann Quidé, Wissam El-Hage, Shmuel Lissek, Hannah Berg, Steven Bruce, Josh Cisler, Marisa Ross, Ryan J Herringa, Daniel W Grupe, Jack B Nitschke, Richard J Davidson, Christine L Larson, Terri A deRoon-Cassini, Carissa W Tomas, Jacklynn M Fitzgerald, Jennifer Urbano Blackford, Bunmi O Olatunji, William S Kremen, Michael J Lyons, Carol E Franz, Evan M Gordon, Geoffrey May, Steven M Nelson, Chadi G Abdallah, Ifat Levy, Ilan Harpaz-Rotem, John H Krystal, Emily L Dennis, David F Tate, David X Cifu, William C Walker, Elizabeth A Wilde, Ian H Harding, Rebecca Kerestes, Paul M Thompson, Rajendra Morey
Although the cerebellum contributes to higher-order cognitive and emotional functions relevant to posttraumatic stress disorder (PTSD), prior research on cerebellar volume in PTSD is scant, particularly when considering subregions that differentially map on to motor, cognitive, and affective functions. In a sample of 4215 adults (PTSD n = 1642; Control n = 2573) across 40 sites from the ENIGMA-PGC PTSD working group, we employed a new state-of-the-art deep-learning based approach for automatic cerebellar parcellation to obtain volumetric estimates for the total cerebellum and 28 subregions...
January 10, 2024: Molecular Psychiatry
https://read.qxmd.com/read/38176652/high-efficacy-of-the-f-atp-synthase-inhibitor-tbaj-5307-against-non-tuberculous-mycobacteria-in-vitro-and-in-vivo
#12
JOURNAL ARTICLE
Priya Ragunathan, Patcharaporn Sae-Lao, Claire Hamela, Matthéo Alcaraz, Alexander Krah, Wee Han Poh, Carmen Jia Ern Pee, Albert Yick Hou Lim, Scott A Rice, Kevin Pethe, Peter John Bond, Thomas Dick, Laurent Kremer, Roderick W Bates, Gerhard Grüber
The F1 FO -ATP synthase engine is essential for viability and growth of non-tuberculous mycobacteria (NTM) by providing the biological energy ATP and keeping ATP homeostasis under hypoxic stress conditions. Here, we report the discovery of the diarylquinoline TBAJ-5307 as a broad spectrum anti-NTM inhibitor, targeting the FO -domain of the engine and preventing rotation and proton-translocation. TBAJ-5307 is active at low nanomolar concentrations against fast- and slow-growing NTM as well as clinical isolates by depleting intrabacterial ATP...
January 2, 2024: Journal of Biological Chemistry
https://read.qxmd.com/read/38142218/clinical-outcomes-associated-with-balloon-aortic-valvuloplasty-in-the-contemporary-era
#13
JOURNAL ARTICLE
Saadat Ali Saleemi, Samer Noaman, John Brookes, Ronald J L Dick
BACKGROUND: Severe aortic stenosis is the most common acquired valvular disorder. Balloon aortic valvuloplasty (BAV) is considered for patients who are not suitable for surgical aortic valve replacement (SAVR) and transcatheter aortic valve insertion (TAVI). The American Heart Association and European Society of Cardiology recommend BAV as a bridging procedure for SAVR and TAVI due to the significant morbidity and mortality associated with it. We aim to investigate the morbidity and mortality associated with BAV only, BAV bridged to TAVI and TAVI-only patients over 3 years in Epworth Richmond, a tertiary hospital in Victoria, Australia...
December 22, 2023: Heart, Lung & Circulation
https://read.qxmd.com/read/38108996/a-developmentally-informative-genome-wide-association-study-of-alcohol-use-frequency
#14
JOURNAL ARTICLE
Nathaniel S Thomas, Nathan A Gillespie, Grace Chan, Howard J Edenberg, Chella Kamarajan, Sally I-Chun Kuo, Alex P Miller, John I Nurnberger, Jay Tischfield, Danielle M Dick, Jessica E Salvatore
Contemporary genome-wide association study (GWAS) methods typically do not account for variability in genetic effects throughout development. We applied genomic structural equation modeling to combine developmentally-informative phenotype data and GWAS to create polygenic scores (PGS) for alcohol use frequency that are specific to developmental stage. Longitudinal cohort studies targeted for gene-identification analyses include the Collaborative Study on the Genetics of Alcoholism (adolescence n = 1,118, early adulthood n = 2,762, adulthood n = 5,255), the National Longitudinal Study of Adolescent to Adult Health (adolescence n = 3,089, early adulthood n = 3,993, adulthood n = 5,149), and the Avon Longitudinal Study of Parents and Children (ALSPAC; adolescence n = 5,382, early adulthood n = 3,613)...
December 18, 2023: Behavior Genetics
https://read.qxmd.com/read/38106088/single-cell-dissection-of-developmental-origins-and-transcriptional-heterogeneity-in-b-cell-acute-lymphoblastic-leukemia
#15
Ilaria Iacobucci, Andy G X Zeng, Qingsong Gao, Laura Garcia-Prat, Pradyumna Baviskar, Sayyam Shah, Alex Murison, Veronique Voisin, Michelle Chan-Seng-Yue, Cheng Cheng, Chunxu Qu, Colin Bailey, Matthew Lear, Matthew T Witkowski, Xin Zhou, Airen Zaldivar Peraza, Karishma Gangwani, Anjali S Advani, Selina M Luger, Mark R Litzow, Jacob M Rowe, Elisabeth M Paietta, Wendy Stock, John E Dick, Charles G Mullighan
Sequencing of bulk tumor populations has improved genetic classification and risk assessment of B-ALL, but does not directly examine intratumor heterogeneity or infer leukemia cellular origins. We profiled 89 B-ALL samples by single-cell RNA-seq (scRNA-seq) and compared them to a reference map of normal human B-cell development established using both functional and molecular assays. Intra-sample heterogeneity was driven by cell cycle, metabolism, differentiation, and inflammation transcriptional programs. By inference of B lineage developmental state composition, nearly all samples possessed a high abundance of pro-B cells, with variation between samples mainly driven by sub-populations...
December 9, 2023: bioRxiv
https://read.qxmd.com/read/38076938/normative-modeling-of-brain-morphometry-across-the-lifespan-using-centilebrain-algorithm-benchmarking-and-model-optimization
#16
Ruiyang Ge, Yuetong Yu, Yi Xuan Qi, Yunan Vera Fan, Shiyu Chen, Chuntong Gao, Shalaila S Haas, Amirhossein Modabbernia, Faye New, Ingrid Agartz, Philip Asherson, Rosa Ayesa-Arriola, Nerisa Banaj, Tobias Banaschewski, Sarah Baumeister, Alessandro Bertolino, Dorret I Boomsma, Stefan Borgwardt, Josiane Bourque, Daniel Brandeis, Alan Breier, Henry Brodaty, Rachel M Brouwer, Randy Buckner, Jan K Buitelaar, Dara M Cannon, Xavier Caseras, Simon Cervenka, Patricia J Conrod, Benedicto Crespo-Facorro, Fabrice Crivello, Eveline A Crone, Liewe de Haan, Greig I de Zubicaray, Annabella Di Giorgio, Susanne Erk, Simon E Fisher, Barbara Franke, Thomas Frodl, David C Glahn, Dominik Grotegerd, Oliver Gruber, Patricia Gruner, Raquel E Gur, Ruben C Gur, Ben J Harrison, Sean N Hatton, Ian Hickie, Fleur M Howells, Hilleke E Hulshoff Pol, Chaim Huyser, Terry L Jernigan, Jiyang Jiang, John A Joska, René S Kahn, Andrew J Kalnin, Nicole A Kochan, Sanne Koops, Jonna Kuntsi, Jim Lagopoulos, Luisa Lazaro, Irina S Lebedeva, Christine Lochner, Nicholas G Martin, Bernard Mazoyer, Brenna C McDonald, Colm McDonald, Katie L McMahon, Tomohiro Nakao, Lars Nyberg, Fabrizio Piras, Maria J Portella, Jiang Qiu, Joshua L Roffman, Perminder S Sachdev, Nicole Sanford, Theodore D Satterthwaite, Andrew J Saykin, Gunter Schumann, Carl M Sellgren, Kang Sim, Jordan W Smoller, Jair Soares, Iris E Sommer, Gianfranco Spalletta, Dan J Stein, Christian K Tamnes, Sophia I Thomopolous, Alexander S Tomyshev, Diana Tordesillas-Gutiérrez, Julian N Trollor, Dennis van 't Ent, Odile A van den Heuvel, Theo Gm van Erp, Neeltje Em van Haren, Daniela Vecchio, Dick J Veltman, Henrik Walter, Yang Wang, Bernd Weber, Dongtao Wei, Wei Wen, Lars T Westlye, Lara M Wierenga, Steven Cr Williams, Margaret J Wright, Sarah Medland, Mon-Ju Wu, Kevin Yu, Neda Jahanshad, Paul M Thompson, Sophia Frangou
We present an empirically benchmarked framework for sex-specific normative modeling of brain morphometry that can inform about the biological and behavioral significance of deviations from typical age-related neuroanatomical changes and support future study designs. This framework was developed using regional morphometric data from 37,407 healthy individuals (53% female; aged 3-90 years) following a comparative evaluation of eight algorithms and multiple covariate combinations pertaining to image acquisition and quality, parcellation software versions, global neuroimaging measures, and longitudinal stability...
December 2, 2023: bioRxiv
https://read.qxmd.com/read/38058956/polygenic-contributions-to-suicidal-thoughts-and-behaviors-in-a-sample-ascertained-for-alcohol-use-disorders
#17
JOURNAL ARTICLE
Sarah M C Colbert, Niamh Mullins, Grace Chan, Jacquelyn L Meyers, Jessica Schulman, Samuel Kuperman, Dongbing Lai, John Nurnberger, Martin H Plawecki, Chella Kamarajan, Andrey P Anokhin, Kathleen K Bucholz, Victor Hesselbrock, Howard J Edenberg, John Kramer, Danielle M Dick, Bernice Porjesz, Arpana Agrawal, Emma C Johnson
INTRODUCTION: Suicidal thoughts and behaviors have partially distinct genetic etiologies. METHODS: We used PRS-CS to create polygenic risk scores (PRSs) from GWAS of non-suicidal self-injury, broad-sense self-harm ideation, nonfatal suicide attempt, death by suicide, and depression. Using mixed-effect models, we estimated whether these PRSs were associated with a range of suicidal thoughts and behaviors in the Collaborative Study on the Genetics of Alcoholism ( N = 7,526)...
2023: Complex psychiatry
https://read.qxmd.com/read/38054532/associations-between-alcohol-use-disorder-polygenic-score-and-remission-in-participants-from-high-risk-families-and-indiana-biobank
#18
JOURNAL ARTICLE
Dongbing Lai, Sally I-Chun Kuo, Leah Wetherill, Fazil Aliev, Michael Zhang, Abreu Marco, Tae-Hwi Schwantes-An, Danielle Dick, Meredith W Francis, Emma C Johnson, Chella Kamarajan, Sivan Kinreich, Samuel Kuperman, Jacquelyn Meyers, John I Nurnberger, Yunlong Liu, Howard J Edenberg, Bernice Porjesz, Arpana Agrawal, Tatiana Foroud, Marc Schuckit, Martin H Plawecki, Kathleen K Bucholz, Vivia V McCutcheon
BACKGROUND: In the U.S., ~50% of those who meet criteria for alcohol use disorder (AUD) during their lifetimes do not remit. We previously reported that a polygenic score for AUD (PGSAUD ) was positively associated with AUD severity as measured by DSM-5 lifetime criteria count, and AUD severity was negatively associated with remission, therefore, we hypothesized that PGSAUD would be negatively associated with remission. METHODS: Individuals of European (EA) and African ancestry (AA) from the Collaborative Study on the Genetics of Alcoholism (COGA) who met lifetime criteria for AUD, and two EA cohorts ascertained for studying liver diseases and substance use disorders, respectively, from Indiana Biobank, were included...
December 6, 2023: Alcohol Clin Exp Res (Hoboken)
https://read.qxmd.com/read/38043569/quality-of-patch-testing-patient-s-own-material-in-patients-with-suspected-occupational-skin-diseases-throughout-germany-interim-results-of-the-german-social-accident-insurance-dguv-research-project-fb-317b
#19
JOURNAL ARTICLE
Cara Symanzik, Katja Dicke, Patricia Weinert, Elke Weisshaar, Richard Brans, Christoph Skudlik, Swen M John, Lara Obermeyer
BACKGROUND: Due to limited availability of commercial test preparations, patch testing patient's own material (POM) is of great importance to diagnose occupational allergic contact dermatitis. OBJECTIVES: To assess the quality of performance and documentation of patch testing with POM in patients with suspected occupational skin diseases (OSD) in Germany. METHODS: Retrospective-prospective analysis of protocols of patch tests with POM was conducted between 2013 and 2021 in patients with suspected OSD and submitted to statutory accident insurance institutions...
December 3, 2023: Contact Dermatitis
https://read.qxmd.com/read/38040538/cascade-testing-of-children-and-adolescents-for-elevated-lp-a-in-pedigrees-with-familial-hypercholesterolaemia
#20
JOURNAL ARTICLE
Wann Jia Loh, Jing Pang, Anindita Chakraborty, Natalie C Ward, Dick C Chan, Amanda J Hooper, Damon A Bell, John R Burnett, Andrew C Martin, Gerald F Watts
Elevated plasma lipoprotein(a) [Lp(a)] is a common, inherited condition independently causing cardiovascular disease. Recent expert recommendations suggest opportunistically testing for elevated Lp(a) during cascade testing for familial hypercholesterolaemia (FH). We investigated the effectiveness of detecting elevated Lp(a) in 103 children and adolescents who were first-degree relatives of 66 adult index FH cases as part of an established FH cascade screening program. The yield of detection of elevated Lp(a) using a threshold of ≥30 mg/dL in children and adolescents was assessed...
November 17, 2023: Journal of Clinical Lipidology
keyword
keyword
48643
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.