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https://www.readbyqxmd.com/read/28528045/endovascular-fenestration-for-distal-aortic-sealing-after-frozen-elephant-trunk-with-thoraflex
#1
Randolph H L Wong, Peter S Y Yu, Micky W T Kwok, Simon C Y Chow, Jacky Y K Ho, Malcolm J Underwood, Simon C H Yu
We describe a case of total arch replacement with frozen elephant trunk for chronic type B aortic dissecting aneurysm, which resulted in inadvertent landing of the frozen elephant trunk into the false lumen. A radiofrequency puncture system-assisted controlled endovascular fenestration of the dissection flap was performed at the upper abdominal aorta and subsequent thoracic endovascular stenting, successfully redirecting the blood flow from the false to the true lumen. Our case illustrated a possible way to seal distal reentry in chronic type B aortic dissection...
June 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28513189/transcatheter-aortic-valve-implantation-the-transaortic-approach
#2
Simon Cy Chow, Gary Sh Cheung, Alex Pw Lee, Eugene B Wu, Jacky Yk Ho, Micky Wt Kwok, Peter Sy Yu, Innes Yp Wan, Malcolm J Underwood, Randolph Hl Wong
Background Transcatheter aortic valve implantation has been established as a safe and effective treatment option for patients at high or prohibitive surgical risk. However, some patients may not be suitable for the transfemoral approach due to severe iliofemoral disease or aneurysmal disease of the thoracoabdominal aorta. The aim of this case series was to evaluate the feasibility and clinical outcomes of the transaortic approach. Methods From May 2015 to June 2016, 5 patients (mean age 78.4 ± 3.9 years) with severe symptomatic aortic stenosis underwent transaortic transcatheter aortic valve implantation after a heart team discussion...
January 1, 2017: Asian Cardiovascular & Thoracic Annals
https://www.readbyqxmd.com/read/28479861/effects-of-dietary-carbohydrate-on-weight-gain-and-gonad-production-in-small-sea-urchins-lytechinus-variegatus
#3
Anna M Taylor, Laura E Heflin, Mickie L Powell, Addison L Lawrence, Stephen A Watts
In experiment 1, juvenile sea urchins (n = 80, 0.088 ± 0.001 g wet weight and 5.72 ± 0.04 mm diameter) were held individually and fed ad libitum one of three semi-purified formulated diets (n = 16 individuals treatment(-1)). In the diets, protein was held constant (310g kg(-1) dry, as fed) and carbohydrate level varied (190, 260, or 380 g kg(-1) dry, as fed). Wet weights were measured every 2 weeks. Total wet weight gain was inversely proportional to dietary carbohydrate level and energy content of the respective diet...
April 2017: Aquaculture Nutrition
https://www.readbyqxmd.com/read/28475316/pentafluorosulfanyl-substituted-benzopyran-analogues-as-new-cyclooxygenase-2-inhibitors-with-excellent-pharmacokinetics-and-efficacy-in-blocking-inflammation
#4
Yanmei Zhang, Yican Wang, Chuang He, Xiaorong Liu, Yongzhi Lu, Tingting Chen, Qiong Pan, Jingfang Xiong, Miaoqin She, Zhengchao Tu, Xiaochu Qin, Minke Li, Micky D Tortorella, John J Talley
In this report, we disclose the design and synthesis of a series of pentafluorosulfanyl (SF5) benzopyran derivatives as novel COX-2 inhibitors with improved pharmacokinetic and pharmacodynamic properties. The pentafluorosulfanyl compounds showed both potency and selectivity for COX-2 and demonstrated efficacy in several murine models of inflammation and pain. More interestingly, one of the compounds, R,S-3a, revealed exceptional efficacy in the adjuvant induced arthritis (AIA) model, achieving an ED50 as low as 0...
May 5, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28453843/inflammation-and-immune-activation-in-antiretroviral-treated-human-immunodeficiency-virus-type-1-infected-african-infants-and-rotavirus-vaccine-responses
#5
Priyanka Uprety, Jane C Lindsey, Myron J Levin, Kaitlin Rainwater-Lovett, Carrie Ziemniak, Mutsa Bwakura-Dangarembizix, Susan S Kaplan, Micki Nelson, Amanda Zadzilka, Adriana Weinberg, Deborah Persaud
00880698.
March 15, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28380358/lineage-specific-differentiation-is-influenced-by-state-of-human-pluripotency
#6
Jong-Hee Lee, Sarah Laronde, Tony J Collins, Zoya Shapovalova, Borko Tanasijevic, Jamie D McNicol, Aline Fiebig-Comyn, Yannick D Benoit, Jung Bok Lee, Ryan R Mitchell, Mickie Bhatia
Human pluripotent stem cells (hPSCs) have been reported in naive and primed states. However, the ability to generate mature cell types remains the imperative property for utility of hPSCs. Here, we reveal that the naive state enhances self-renewal while restricting lineage differentiation in vitro to neural default fate. Molecular analyses indicate expression of multiple lineage-associated transcripts in naive hPSCs that failed to predict biased functional differentiation capacity. Naive hPSCs can be converted to primed state over long-term serial passage that permits recovery of multi-germ layer differentiation...
April 4, 2017: Cell Reports
https://www.readbyqxmd.com/read/28287020/exploring-informal-workplace-learning-in-primary-healthcare-for-continuous-professional-development
#7
Viktoria Joynes, Micky Kerr, Tamsin Treasure-Jones
BACKGROUND AND OBJECTIVES: All health and social care professionals learn on the job through both formal and informal learning processes, which contributes to continuous professional development (CPD). This study explored workplace learning in General Practices, specifically looking at the role of informal learning and the workplace practices that appear to support or restrict that learning, as well as how technology was integrated into these learning processes. METHODS: Three focus groups with general practitioners, practice nurses, managerial and administrative staff were conducted followed by twelve individual semi-structured interviews with participants drawn from the focus groups...
March 12, 2017: Education for Primary Care
https://www.readbyqxmd.com/read/28245350/cardiovascular-safety-of-tocilizumab-versus-tumor-necrosis-factor-inhibitors-in-patients-with-rheumatoid-arthritis-a-multi-database-cohort-study
#8
Seoyoung C Kim, Daniel H Solomon, James R Rogers, Sara Gale, Micki Klearman, Khaled Sarsour, Sebastian Schneeweiss
OBJECTIVE: While tocilizumab (TCZ) is known to increase low-density lipoprotein (LDL) cholesterol levels, it is unclear whether TCZ increases cardiovascular risk in patients with rheumatoid arthritis (RA). This study was undertaken to compare the cardiovascular risk associated with receiving TCZ versus tumor necrosis factor inhibitors (TNFi). METHODS: To examine comparative cardiovascular safety, we conducted a cohort study of RA patients who newly started TCZ or TNFi using claims data from Medicare, IMS PharMetrics, and MarketScan...
February 28, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28235409/acetazolamide-potentiates-the-anti-tumor-potential-of-hdaci-ms-275-in-neuroblastoma
#9
Reza Bayat Mokhtari, Narges Baluch, Micky Ka Hon Tsui, Sushil Kumar, Tina S Homayouni, Karen Aitken, Bikul Das, Sylvain Baruchel, Herman Yeger
BACKGROUND: Neuroblastoma (NB), a tumor of the primitive neural crest, despite aggressive treatment portends a poor long-term survival for patients with advanced high stage NB. New treatment strategies are required. METHODS: We investigated coordinated targeting of essential homeostatic regulatory factors involved in cancer progression, histone deacetylases (HDACs) and carbonic anhydrases (CAs). RESULTS: We evaluated the antitumor potential of the HDAC inhibitor (HDACi), pyridylmethyl-N-{4-[(2-aminophenyl)-carbamoyl]-benzyl}-carbamate (MS-275) in combination with a pan CA inhibitor, acetazolamide (AZ) on NB SH-SY5Y, SK-N-SH and SK-N-BE(2) cells...
February 24, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28216254/cardiac-sarcoidosis-diagnostic-challenges-due-to-unusual-clinical-presentation
#10
Karolis Kluonaitis, Sigita Glaveckaite, Giedre Balciunaite, Austeja Juskaite, Darius Palionis, Nomeda Valeviciene, Ugnius Mickys, Rimgaudas Katkus, Ricardo Fontes-Carvalho, Jelena Celutkiene
No abstract text is available yet for this article.
February 16, 2017: Hellenic Journal of Cardiology: HJC, Hellēnikē Kardiologikē Epitheōrēsē
https://www.readbyqxmd.com/read/28168269/inflammation-and-immune-activation-in-antiretroviral-treated-hiv-1-infected-african-infants-and-rotavirus-vaccine-responses
#11
Priyanka Uprety, Jane C Lindsey, Myron J Levin, Kaitlin Rainwater-Lovett, Carrie Ziemniak, Mutsa Bwakura-Dangarembizix, Susan S Kaplan, Micki Nelson, Amanda Zadzilka, Adriana Weinberg, Deborah Persaud
No abstract text is available yet for this article.
February 7, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28167213/metagenomics-approach-to-the-study-of-the-gut-microbiome-structure-and-function-in-zebrafish-danio-rerio-fed-with-gluten-formulated-diet
#12
Hyunmin Koo, Joseph A Hakim, Mickie L Powell, Ranjit Kumar, Peter G Eipers, Casey D Morrow, Michael Crowley, Elliot J Lefkowitz, Stephen A Watts, Asim K Bej
In this study, we report the gut microbial composition and predictive functional profiles of zebrafish, Danio rerio, fed with a control formulated diet (CFD), and a gluten formulated diet (GFD) using a metagenomics approach and bioinformatics tools. The microbial communities of the GFD-fed D. rerio displayed heightened abundances of Legionellales, Rhizobiaceae, and Rhodobacter, as compared to the CFD-fed counterparts. Predicted metagenomics of microbial communities (PICRUSt) in GFD-fed D. rerio showed KEGG functional categories corresponding to bile secretion, secondary bile acid biosynthesis, and the metabolism of glycine, serine, and threonine...
February 3, 2017: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/28164422/effect-of-prophylactic-topical-hypotensive-medications-in-reducing-the-incidence-of-postoperative-ocular-hypertension-after-phacoemulsification-in-dogs
#13
D Dustin Dees, Kate J Spahn, Lynsey Smith Wagner, Andrew Greller, Danielle Paglia, Micki D Armour, Richard Madsen
OBJECTIVE: To determine whether topical hypotensive medications prevent postoperative ocular hypertension (POH) after phacoemulsification. ANIMALS STUDIED: 52 client-owned dogs (88 eyes). PROCEDURES: Diabetic and nondiabetic dogs having undergone phacoemulsification were included in this retrospective study. The control group received no ocular hypotensive medications. The treatment groups received latanoprost, dorzolamide, or dorzolamide/timolol, beginning immediately after surgery, for 2-week duration...
February 6, 2017: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/28040244/serious-adverse-effects-associated-with-glucocorticoid-therapy-in-patients-with-giant-cell-arteritis-gca-a-nested-case-control-analysis
#14
Jessica C Wilson, Khaled Sarsour, Neil Collinson, Katie Tuckwell, David Musselman, Micki Klearman, Pavel Napalkov, Susan S Jick, John H Stone, Christoph R Meier
OBJECTIVE: Giant cell arteritis (GCA) is an inflammatory vasculitis preferentially affecting large and medium-sized arteries. High-dose oral glucocorticoids (GCs) are the mainstay of GCA therapy. Using data from the UK Clinical Practice Research Datalink (CPRD), we examined the risk of oral GC-related serious adverse events (SAEs) in a UK population of patients with giant cell arteritis (GCA). METHODS: We conducted a series of nested case-control analyses in GCA patients to examine the effect of increasing dose of prednisolone on the risk of developing diabetes, glaucoma, osteoporosis, fractures, serious infection requiring hospitalization, and death...
November 28, 2016: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28011185/novel-rickettsia-and-emergent-tick-borne-pathogens-a-molecular-survey-of-ticks-and-tick-borne-pathogens-in-shimba-hills-national-reserve-kenya
#15
Micky M Mwamuye, Edward Kariuki, David Omondi, James Kabii, David Odongo, Daniel Masiga, Jandouwe Villinger
Ticks are important vectors of emerging and re-emerging zoonoses, the majority of which originate from wildlife. In recent times, this has become a global public health concern that necessitates surveillance of both known and unknown tick-borne pathogens likely to be future disease threats, as well as their tick vectors. We carried out a survey of the diversity of ticks and tick-borne pathogens in Kenya's Shimba Hills National Reserve (SHNR), an area with intensified human-livestock-wildlife interactions, where we collected 4297 questing ticks (209 adult ticks, 586 nymphs and 3502 larvae)...
September 5, 2016: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/28000522/targeting-the-interferon-pathway-with-sifalimumab-for-the-treatment-of-systemic-lupus-erythematosus
#16
Warren Greth, Gabriel J Robbie, Philip Brohawn, Micki Hultquist, Bing Yao
Dysregulation of the type I interferon (IFN) system is associated with various immunologic diseases, such as systemic lupus erythematosus (SLE). Targeting this dysregulation presents an attractive approach for SLE therapy. Sifalimumab, a fully human immunoglobulin G1 κ monoclonal antibody that binds to and neutralizes most IFN-α subtypes, has been recently evaluated in a Phase IIb study in patients with moderate to severe SLE. Insights gained from earlier studies were used to inform design of the Phase IIb study, to provide a more comprehensive evaluation of sifalimumab...
January 2017: Immunotherapy
https://www.readbyqxmd.com/read/27998620/newly-diagnosed-vs-relapsing-giant-cell-arteritis-baseline-data-from-the-giacta-trial
#17
Katie Tuckwell, Neil Collinson, Sophie Dimonaco, Micki Klearman, Daniel Blockmans, Elisabeth Brouwer, Maria C Cid, Bhaskar Dasgupta, Juergen Rech, Carlo Salvarani, Sebastian H Unizony, John H Stone
OBJECTIVE: To report entry criteria and clinical features of patients with newly diagnosed and relapsing giant cell arteritis (GCA) enrolled in a randomized trial of tocilizumab, an interleukin-6 receptor-alpha inhibitor. METHODS: Newly diagnosed GCA was defined as diagnosis ≤6 weeks before baseline. Relapsing GCA was defined as diagnosis >6 weeks before baseline with ≥2 consecutive weeks of prednisone ≥40mg/day. All patients had active GCA within 6 weeks of baseline...
April 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/27897128/defining-the-limits-of-endoscopic-access-to-internal-auditory-canal
#18
Adam Master, Mickie Hamiter, Maura Cosetti
OBJECTIVE: To quantify surgical access to the internal auditory canal (IAC) using an exclusively endoscopic transcanal approach (EETA) and investigate surgically relevant relationships with neurovascular and osseous landmarks of the temporal bone. MATERIALS AND METHODS: Anatomical dissection of two paired temporal bones and 15 unpaired temporal bones was performed using an exclusively endoscopic approach to IAC. The dissection proceeded until the cerebellopontine angle (CPA) could be accessed...
December 2016: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/27891482/treatment-emergent-agranulocytosis-with-skin-and-gingival-lesions-in-a-chronic-lymphocytic-leukemia-patient-a-case-report
#19
Ramesh Amirisetty, Varun Zade, Meenakshi Boddun, Rolly Gupta, Micky Kumari, Hema Suryawanshi
Chronic Lymphocytic Leukaemia (CLL) is a monoclonal lymphoid malignancy characterized by progressive accumulation of small, mature but functionally incompetent neoplastic lymphocytes in the peripheral blood, bone marrow and lymphoid organs. Patients present a variable course and may not require early intervention unlike other malignancies. Patients with rapidly deteriorating blood counts, and organomegaly need treatment. Alkylating agent live Bendamustine combined with Rituximab, anti-CD 20 monoclonal antibody have shown promising results in such patients...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27886705/the-commission-on-dietetic-registration-ahead-of-the-trends-for-a-competent-21st-century-workforce
#20
Karen Stein, Mickie Rops
No abstract text is available yet for this article.
December 2016: Journal of the Academy of Nutrition and Dietetics
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