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https://www.readbyqxmd.com/read/29113101/effects-of-airborne-particulate-matter-on-respiratory-health-in-a-community-near-a-cement-factory-in-chilanga-zambia-results-from-a-panel-study
#1
Emmy Nkhama, Micky Ndhlovu, J Timothy Dvonch, Mary Lynam, Graciela Mentz, Seter Siziya, Kuku Voyi
We conducted a panel study to investigate seasonal variations in concentrations of airborne PM2.5 and PM10 and the effects on respiratory health in a community near a cement factory; in Chilanga; Zambia. A panel of 63 and 55 participants aged 21 to 59 years from a community located at the edge of the factory within 1 km and a control community located 18 km from the factory respectively; were followed up for three climatic seasons July 2015 to February 2016. Symptom diary questionnaires were completed and lung function measurements taken daily for 14 days in each of the three climatic seasons...
November 6, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29103738/a-pilot-study-of-merkel-cell-polyomavirus-in-squamous-cell-carcinoma-of-the-tongue
#2
Mickie Hamiter, Ameya Asarkar, Donna Rogers, Tara Moore-Medlin, Gloria McClure, Xiaohui Ma, John Vanchiere, Cherie-Ann O Nathan
No abstract text is available yet for this article.
November 2017: Oral Oncology
https://www.readbyqxmd.com/read/29097778/structural-insight-into-inhibition-of-csra-rna-interaction-revealed-by-docking-molecular-dynamics-and-free-energy-calculations
#3
Xiaodong Ren, Rui Zeng, Micky Tortorella, Jinming Wang, Changwei Wang
The carbon storage regulator A (CsrA) and its homologs play an important role in coordinating the expression of bacterial virulence factors required for successful host infection. In addition, bacterial pathogens with deficiency of CsrA are typically attenuated for virulence. In 2016, the first series of small-molecule inhibitors of CsrA-RNA interaction were identified, which were found to achieve the CsrA-RNA inhibition by binding to the CsrA, without interfering with the RNA. However, the binding mechanism of these inhibitors of CsrA is not known...
November 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29035359/acute-myeloid-leukaemia-disrupts-endogenous-myelo-erythropoiesis-by-compromising-the-adipocyte-bone-marrow-niche
#4
Allison L Boyd, Jennifer C Reid, Kyle R Salci, Lili Aslostovar, Yannick D Benoit, Zoya Shapovalova, Mio Nakanishi, Deanna P Porras, Mohammed Almakadi, Clinton J V Campbell, Michael F Jackson, Catherine A Ross, Ronan Foley, Brian Leber, David S Allan, Mitchell Sabloff, Anargyros Xenocostas, Tony J Collins, Mickie Bhatia
Acute myeloid leukaemia (AML) is distinguished by the generation of dysfunctional leukaemic blasts, and patients characteristically suffer from fatal infections and anaemia due to insufficient normal myelo-erythropoiesis. Direct physical crowding of bone marrow (BM) by accumulating leukaemic cells does not fully account for this haematopoietic failure. Here, analyses from AML patients were applied to both in vitro co-culture platforms and in vivo xenograft modelling, revealing that human AML disease specifically disrupts the adipocytic niche in BM...
November 2017: Nature Cell Biology
https://www.readbyqxmd.com/read/29020600/trial-of-tocilizumab-in-giant-cell-arteritis
#5
LETTER
John H Stone, Micki Klearman, Neil Collinson
New England Journal of Medicine, Volume 377, Issue 15, Page 1493-1495, October 2017.
October 12, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28958344/medical-nutrition-therapy-and-weight-loss-questions-for-the-evidence-analysis-library-prevention-of-type-2-diabetes-project-systematic-reviews
#6
REVIEW
Hollie A Raynor, Patricia G Davidson, Heather Burns, Micki D Hall Nadelson, Shelley Mesznik, Virginia Uhley, Lisa Moloney
BACKGROUND: Eleven recommendations, based on systematic reviews, were developed for the Evidence Analysis Library's prevention of type 2 diabetes project. Two recommendations, medical nutrition therapy (MNT) and weight loss, were rated strong. OBJECTIVE: Present the basis of systematic reviews for MNT and weight loss recommendations. METHODS: Literature searches using Medline were conducted to identify studies that met eligibility criteria...
October 2017: Journal of the Academy of Nutrition and Dietetics
https://www.readbyqxmd.com/read/28958299/the-commission-on-dietetic-registration-ahead-of-the-trends-for-a-competent-21st-century-workforce
#7
Karen Stein, Mickie Rops
No abstract text is available yet for this article.
October 2017: Journal of the Academy of Nutrition and Dietetics
https://www.readbyqxmd.com/read/28935470/efficacy-and-safety-of-a-pentavalent-live-human-bovine-reassortant-rotavirus-vaccine-rv5-in-healthy-chinese-infants-a-randomized-double-blind-placebo-controlled-trial
#8
Zhaojun Mo, Yi Mo, Mingqiang Li, Junhui Tao, Xu Yang, Jilian Kong, Dingkai Wei, Botao Fu, Xueyan Liao, Jianli Chu, Yuanzheng Qiu, Darcy A Hille, Micki Nelson, Susan S Kaplan
BACKGROUND: A randomized, double-blind, placebo-controlled multicenter trial was conducted in healthy Chinese infants to assess the efficacy and safety of a pentavalent live human-bovine reassortant rotavirus vaccine (RotaTeq™, RV5) against rotavirus gastroenteritis (RVGE). METHODS: 4040 participants aged 6-12weeks were enrolled and randomly assigned to either 3 oral doses of RV5 (n=2020) or placebo (n=2020), administered ∼4weeks apart. The participants also received OPV and DTaP in a concomitant or staggered fashion...
September 18, 2017: Vaccine
https://www.readbyqxmd.com/read/28902438/colony-level-behavioural-variation-correlates-with-differences-in-expression-of-the-foraging-gene-in-red-imported-fire-ants
#9
Alison A Bockoven, Craig J Coates, Micky D Eubanks
Among social insects, colony-level variation is likely to be widespread and has significant ecological consequences. Very few studies, however, have documented how genetic factors relate to behaviour at the colony level. Differences in expression of the foraging gene have been associated with differences in foraging and activity of a wide variety of organisms. We quantified expression of the red imported fire ant foraging gene (sifor) in workers from 21 colonies collected across the natural range of Texas fire ant populations, but maintained under standardized, environmentally controlled conditions...
September 13, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28877012/the-hitech-era-in-retrospect
#10
John D Halamka, Micky Tripathi
At a high level, the Health Information Technology for Economic and Clinical Health (HITECH) Act of 2009 accomplished something miraculous: the vast majority of U.S. hospitals and physicians are now active users of electronic health record (EHR) systems. No other sector of the U.S. economy of..
September 7, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28863773/down-regulation-of-mirna-148a-and-mirna-625-3p-in-colorectal-cancer-is-associated-with-tumor-budding
#11
Edita Baltruskeviciene, Diana Schveigert, Vaidotas Stankevicius, Ugnius Mickys, Tadas Zvirblis, Jaroslav Bublevic, Kestutis Suziedelis, Eduardas Aleknavicius
BACKGROUND: MiRNAs are often deregulated in colorectal cancer and might function as tumor suppressors or as oncogenes. They participate in controlling key signaling pathways involved in proliferation, invasion and apoptosis and may serve as prognostic and predictive markers. In this study we aimed to evaluate the role of miRNA-148a and miRNA-625-3p in metastatic colorectal cancer. METHODS: Fifty-four patients with a first-time diagnosed CRC receiving FOLFOX ± Bevacizumab were involved in the study...
September 1, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28758276/brief-report-human-acute-myeloid-leukemia-reprograming-to-pluripotency-is-a-rare-event-and-selects-for-patient-hematopoietic-cells-devoid-of-leukemic-mutations
#12
Jong-Hee Lee, Kyle R Salci, Jennifer C Reid, Luca Orlando, Borko Tanasijevic, Zoya Shapovalova, Mickie Bhatia
Induced pluripotent stem cell reprogramming has provided critical insights into disease processes by modeling the genetics and related clinical pathophysiology. Human cancer represents highly diverse genetics, as well as inter- and intra-patient heterogeneity, where cellular model systems capable of capturing this disease complexity would be invaluable. Acute myeloid leukemia (AML) represents one of most heterogeneous cancers and has been divided into genetic subtypes correlated with unique risk stratification over the decades...
July 31, 2017: Stem Cells
https://www.readbyqxmd.com/read/28745999/trial-of-tocilizumab-in-giant-cell-arteritis
#13
RANDOMIZED CONTROLLED TRIAL
John H Stone, Katie Tuckwell, Sophie Dimonaco, Micki Klearman, Martin Aringer, Daniel Blockmans, Elisabeth Brouwer, Maria C Cid, Bhaskar Dasgupta, Juergen Rech, Carlo Salvarani, Georg Schett, Hendrik Schulze-Koops, Robert Spiera, Sebastian H Unizony, Neil Collinson
BACKGROUND: Giant-cell arteritis commonly relapses when glucocorticoids are tapered, and the prolonged use of glucocorticoids is associated with side effects. The effect of the interleukin-6 receptor alpha inhibitor tocilizumab on the rates of relapse during glucocorticoid tapering was studied in patients with giant-cell arteritis. METHODS: In this 1-year trial, we randomly assigned 251 patients, in a 2:1:1:1 ratio, to receive subcutaneous tocilizumab (at a dose of 162 mg) weekly or every other week, combined with a 26-week prednisone taper, or placebo combined with a prednisone taper over a period of either 26 weeks or 52 weeks...
July 27, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28676940/prior-experiences-of-behavioral-health-treatment-among-uninsured-young-adults-served-in-a-psychiatric-crisis-setting
#14
Sarah Carter Narendorf, Richard Wagner, Nicole Fedoravicius, Micki Washburn
This study qualitatively explored the past treatment experiences of uninsured young adults who sought public emergency psychiatric care. Qualitative interviews were conducted with a racially diverse sample of 55 young adults (ages 18-25) using a semi-structured interview guide, and analyzed using a team-based open coding approach. Findings emerged in three broad areas-provider-related factors, treatment-related factors, and environmental factors. Young adults talked about the importance of providers respecting and listening to them, the perceived advantages and disadvantages of therapy and medication treatment, and aspects of the environment that resulted in positive and negative experiences, particularly in inpatient settings...
July 4, 2017: Community Mental Health Journal
https://www.readbyqxmd.com/read/28660365/do-work-characteristics-predict-health-deterioration-among-employees-with-chronic-diseases
#15
Astrid de Wind, Cécile R L Boot, Ranu Sewdas, Micky Scharn, Swenne G van den Heuvel, Allard J van der Beek
Purpose In our ageing workforce, the increasing numbers of employees with chronic diseases are encouraged to prolong their working lives. It is important to prevent health deterioration in this vulnerable group. This study aims to investigate whether work characteristics predict health deterioration over a 3-year period among employees with (1) chronic diseases, and, more specifically, (2) musculoskeletal and psychological disorders. Methods The study population consisted of 5600 employees aged 45-64 years with a chronic disease, who participated in the Dutch Study on Transitions in Employment, Ability and Motivation (STREAM)...
June 29, 2017: Journal of Occupational Rehabilitation
https://www.readbyqxmd.com/read/28648376/sam68-allows-selective-targeting-of-human-cancer-stem-cells
#16
Yannick D Benoit, Ryan R Mitchell, Ruth M Risueño, Luca Orlando, Borko Tanasijevic, Allison L Boyd, Lili Aslostovar, Kyle R Salci, Zoya Shapovalova, Jennifer Russell, Masakatsu Eguchi, Diana Golubeva, Monica Graham, Anargyros Xenocostas, Michael R Trus, Ronan Foley, Brian Leber, Tony J Collins, Mickie Bhatia
Targeting of human cancer stem cells (CSCs) requires the identification of vulnerabilities unique to CSCs versus healthy resident stem cells (SCs). Unfortunately, dysregulated pathways that support transformed CSCs, such as Wnt/β-catenin signaling, are also critical regulators of healthy SCs. Using the ICG-001 and CWP family of small molecules, we reveal Sam68 as a previously unappreciated modulator of Wnt/β-catenin signaling within CSCs. Disruption of CBP-β-catenin interaction via ICG-001/CWP induces the formation of a Sam68-CBP complex in CSCs that alters Wnt signaling toward apoptosis and differentiation induction...
July 20, 2017: Cell Chemical Biology
https://www.readbyqxmd.com/read/28620610/molecular-detection-of-tick-borne-pathogen-diversities-in-ticks-from-livestock-and-reptiles-along-the-shores-and-adjacent-islands-of-lake-victoria-and-lake-baringo-kenya
#17
David Omondi, Daniel K Masiga, Burtram C Fielding, Edward Kariuki, Yvonne Ukamaka Ajamma, Micky M Mwamuye, Daniel O Ouso, Jandouwe Villinger
Although diverse tick-borne pathogens (TBPs) are endemic to East Africa, with recognized impact on human and livestock health, their diversity and specific interactions with tick and vertebrate host species remain poorly understood in the region. In particular, the role of reptiles in TBP epidemiology remains unknown, despite having been implicated with TBPs of livestock among exported tortoises and lizards. Understanding TBP ecologies, and the potential role of common reptiles, is critical for the development of targeted transmission control strategies for these neglected tropical disease agents...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/28618383/disassembly-of-micelle-like-polyethylenimine-nanocomplexes-for-sirna-delivery-high-transfection-efficiency-and-reduced-toxicity-achieved-by-simple-reducible-lipid-modification
#18
Gaoyang Guo, Micky Tortorella, Biliang Zhang, Yunbing Wang
Amphiphilic compounds consisting of polycations and lipid segments are well established as building blocks for the construction of siRNA carriers. They are capable of forming nanoparticles with high-affinity positive charges for siRNA in aqueous media due to their intra- and/or intermolecular hydrophobic and electrostatic interactions. Unfortunately, safety and efficiency of lipid-modified polycations as the two great challenges to the clinical application need to be improved. Beyond that, the role of the hydrophobic segment in the process of siRNA delivery is elusive...
May 5, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28599091/burden-of-cytomegalovirus-disease-in-solid-organ-transplant-recipients-a-national-matched-cohort-study-in-an-inpatient-setting
#19
Zalmai Hakimi, Samuel Aballéa, Sameh Ferchichi, Micky Scharn, Isaac A Odeyemi, Mondher Toumi, Faouzi Saliba
BACKGROUND: We investigated the impact of early- (E-CMV) and late onset (L-CMV) cytomegalovirus disease on the probability of graft rejection, graft failure, mortality, and healthcare resource use, following solid organ transplantation (SOT) in France. METHODS: A retrospective analysis of data from the French 'Programme de Médicalisation des Systèmes d'Information' database (2007-2011) was conducted to identify SOT recipients who developed CMV disease in an inpatient setting...
June 9, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/28569662/sliding-scale-insulin-use-in-long-term-care-an-updated-perspective
#20
REVIEW
Joy Woods, Micki Nadelson
Diabetes affects approximately 26% of individuals oldeR THAN 65 years of age in the United States and up to 33% of patients in long-term care facilities. The most commonly prescribed insulin therapy for patients in long-term care is sliding-scale insulin (SSI): the use of finger-stick blood glucose testing to assess the need for insulin administration based on current blood glucose levels. SSI has been on the Beers Criteria of Potentially Inappropriate Medications since 2012. However, its sole use for long-term treatment is specifically not recommended by the American Diabetes Association and other stakeholders in diabetes management...
February 1, 2017: Consultant Pharmacist: the Journal of the American Society of Consultant Pharmacists
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