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Joann F Gruber, Darcy A Hille, G Frank Liu, Susan S Kaplan, Micki Nelson, Michelle G Goveia, T Christopher Mast
BACKGROUND: Rotavirus is the leading cause of severe diarrhea worldwide in young children. Although rotavirus vaccine efficacy is high in developed countries, efficacy is lower in developing countries. Here, we investigated heterogeneity of rotavirus vaccine efficacy by infant characteristics in developing countries. METHODS: An exploratory, post-hoc analysis was conducted using randomized controlled trial data of the pentavalent rotavirus vaccine (RV5) conducted in Africa and Asia (NCT00362648)...
October 17, 2016: Pediatric Infectious Disease Journal
Adrian A Castellanos, Matthew C I Medeiros, Gabriel L Hamer, Michael E Morrow, Micky D Eubanks, Pete D Teel, Sarah A Hamer, Jessica E Light
Invasive species may impact pathogen transmission by altering the distributions and interactions among native vertebrate reservoir hosts and arthropod vectors. Here, we examined the direct and indirect effects of the red imported fire ant (Solenopsis invicta) on the native tick, small mammal and pathogen community in southeast Texas. Using a replicated large-scale field manipulation study, we show that small mammals were more abundant on treatment plots where S. invicta populations were experimentally reduced...
September 2016: Biology Letters
Peter S Y Yu, Simon C H Yu, Cheuk-Man Chu, Micky W T Kwok, Yuk-Hoi Lam, Malcolm J Underwood, Randolph H L Wong
An elderly man presented with fever and evidence of Salmonella infection, and was diagnosed to have coexisting constrictive pericarditis and mycotic aneurysm of the aortic arch. Pericardiectomy was performed under cardiopulmonary bypass with good result. To avoid deep hypothermic circulatory arrest, an aorto-brachiocephalic bypass, instead of total arch replacement, was performed. This was followed by a staged carotid-carotid bypass, thoracic endovascular stent graft placement. He was subsequently treated with prolonged antibiotics, and inflammatory marker normalized afterwards...
August 2016: Journal of Thoracic Disease
Micki Washburn, Patrick Bordnick, Albert Skip Rizzo
This study presents preliminary feasibility and acceptability data on the use of virtual patient (VP) simulations to develop brief assessment skills within an interdisciplinary care setting. Results support the acceptability of technology-enhanced simulations and offer preliminary evidence for an association between engagement in VP practice simulations and improvements in diagnostic accuracy and clinical interviewing skills. Recommendations and next steps for research on technology-enhanced simulations within social work are discussed...
October 2016: Social Work in Health Care
Wei Zhou, Guifa Zhong, Sihai Fu, Hui Xie, Tianyan Chi, Luyi Li, Xiurong Rao, Shaogao Zeng, Dengfeng Xu, Hao Wang, Guoqing Sheng, Xing Ji, Xiaorong Liu, Xue-Fei Ji, Donghai Wu, Libo Zou, Micky D Tortorella, Kejian Zhang, Wenhui Hu
Currently, anti-AD drug discovery using target-based approaches is extremely challenging due to unclear aetiology of AD and absence of validated therapeutic protein targets. Neuronal death, regardless of causes, plays a key role in AD progression, and it is directly linked to neuroinflammation. Meanwhile, phenotypic screening is making a resurgence in drug discovery process as an alternative to target-focused approaches. Herein, we employed microglia-based phenotypic screenings to search for small molecules that modulate the release of detrimental proinflammatory cytokines...
August 9, 2016: ACS Chemical Neuroscience
Peter S Y Yu, Calvin S H Ng, Micky W T Kwok, Malcolm J Underwood, Randolph H L Wong
A 66-year-old man presented with acute type I respiratory failure, and was diagnosed to have a huge mass occupying the right atrium (RA) of the heart, with no evidence of pulmonary embolism. Intra-operative transesophageal echocardiogram identified a patent foramen ovale (PFO) with right-to-left shunt apart from a huge right atrial tumor arising from the atrioventricular groove. The tumor was debulked, and the patent foramen was closed. Patient had an uneventful recovery and WAS discharged on post-operative day 7...
July 2016: Journal of Thoracic Disease
Jingjing Wang, Weijian Li, Xinyu Li, Ping Li, Yuchi Zhang, Xiaoyu Jia, Yue Chen, Mickie Vanhoy, Binghai Sun
This study explored a bidirectional impact on the recognition accuracy of various facial expressions deriving from both the observer and sender in a sample of Chinese participants. A facial manipulation task was used to examine the ability of an observer's facial feedback to modulate the recognition of various facial expressions. Furthermore, the effect of a sender's facial expression with an open or closed mouth on recognition accuracy was investigated. The results showed that only recognition accuracy of a sad facial expression was influenced simultaneously by bidirectional sources from a sender and observer...
August 1, 2016: International Journal of Psychology: Journal International de Psychologie
Song Wan, Alex Pw Lee, Saina Attaran, Peter Sy Yu, Sylvia Sw Au, Micky Wt Kwok, Rainbow Wh Lau, Randolph Hl Wong, Innes Yp Wan, Siu-Keung Ng, Malcolm J Underwood
BACKGROUND: Commonly used complete mitral annuloplastic rings include saddle-shaped and semirigid rings, with no clear indication for either type. A semirigid ring may be preferred in patients whose native mitral saddle shape is well maintained. We present our experience of using semirigid rings for mitral valve repair. METHODS: We routinely measured the annular height-to-commissural width ratio by 3-dimensional transesophageal echocardiography prior to mitral repair...
September 2016: Asian Cardiovascular & Thoracic Annals
Micki M Kuhlmann, Maitreyi Chattopadhyay, Vera A Stupina, Feng Gao, Anne E Simon
UNLABELLED: Ribosome recoding is used by RNA viruses for translational readthrough or frameshifting past termination codons for the synthesis of extension products. Recoding sites, along with downstream recoding stimulatory elements (RSEs), have long been studied in reporter constructs, because these fragments alone mediate customary levels of recoding and are thus assumed to contain complete instructions for establishment of the proper ratio of termination to recoding. RSEs from the Tombusviridae and Luteoviridae are thought to be exceptions, since they contain a long-distance RNA-RNA connection with the 3' end...
October 1, 2016: Journal of Virology
Michael S Broder, Khaled Sarsour, Eunice Chang, Neil Collinson, Katie Tuckwell, Pavel Napalkov, Micki Klearman
OBJECTIVE: Corticosteroids (CS) are standard treatment for giant cell arteritis (GCA), but concerns persist over toxicities associated with long-term use. In this retrospective study of medical claims data, we estimated risks for adverse events (AEs) in CS-treated GCA patients. METHODS: Cox regression analyses with CS use as a time-dependent variable were conducted on data from the 2003 to 2012 Truven Health Analytics MarketScan Database. Patients 50 years of age and older who had ≥2 claims of newly diagnosed GCA, ≥1 filled oral CS prescription, and no AEs before GCA diagnosis were included...
October 2016: Seminars in Arthritis and Rheumatism
Joseph A Hakim, Hyunmin Koo, Ranjit Kumar, Elliot J Lefkowitz, Casey D Morrow, Mickie L Powell, Stephen A Watts, Asim K Bej
In this paper, we describe the microbial composition and their predictive metabolic profile in the sea urchin Lytechinus variegatus gut ecosystem along with samples from its habitat by using NextGen amplicon sequencing and downstream bioinformatics analyses. The microbial communities of the gut tissue revealed a near-exclusive abundance of Campylobacteraceae, whereas the pharynx tissue consisted of Tenericutes, followed by Gamma-, Alpha- and Epsilonproteobacteria at approximately equal capacities. The gut digesta and egested fecal pellets exhibited a microbial profile comprised of Gammaproteobacteria, mainly Vibrio, and Bacteroidetes...
September 2016: FEMS Microbiology Ecology
Michael B Williams, Mickie L Powell, Stephen A Watts
We examined lethality and behavioral effects of Corexit EC 9500A (C-9500A) exposure on the model marine zooplankton Brachionus plicatilis singularly and in combination with abiotic and biotic factors. C-9500A exposure at standard husbandry conditions (17.5ppt, 24°C, 200 rotifer*mL(-1) density) identified the 24h median lethal concentration, by Probit analysis, to be 107ppm for cultured B. plicatilis. Rotifers surviving exposure to higher concentrations (100 and 150ppm) exhibited a decreased swimming velocity and a reduced net to gross movement ratio...
October 2016: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
Allison L Boyd, Mickie Bhatia
Increasing attention has been focused on the interactions between leukemia cells and their bone marrow (BM) microenvironment. We have recently shown that leukemic stem cells (LSCs) share common BM "niches" with their healthy counterparts. As a result of these shared niche requirements, human LSCs can be mobilized using existing pharmacological agents that facilitate competitive healthy reconstitution, leading to eradication of leukemia during BM transplantation.
July 2015: Molecular & Cellular Oncology
Micky Tripathi, Elizabeth Gardner
No abstract text is available yet for this article.
March 2016: Health Data Management
Stephen A Watts, Christian Lawrence, Mickie Powell, Louis R D'Abramo
In the relatively short span of four decades, the zebrafish (Danio rerio) has emerged as an increasingly important model organism for biomedicine and other scientific disciplines. As the scale and sophistication of zebrafish research expands, so too does the need to develop standards that promote the production and maintenance of healthy animals for experiments. A major, but long overlooked, contributor to fish health is nutrition. Historically, feeding practices for laboratory zebrafish have been designed to promote growth and reproductive function...
July 2016: Zebrafish
Jennifer Irvin Vidrine, Claire Adams Spears, Whitney L Heppner, Lorraine R Reitzel, Marianne T Marcus, Paul M Cinciripini, Andrew J Waters, Yisheng Li, Nga Thi To Nguyen, Yumei Cao, Hilary A Tindle, Micki Fine, Linda V Safranek, David W Wetter
OBJECTIVE: To compare the efficacy of Mindfulness-Based Addiction Treatment (MBAT) to a Cognitive Behavioral Treatment (CBT) that matched MBAT on treatment contact time, and a Usual Care (UC) condition that comprised brief individual counseling. METHOD: Participants (N = 412) were 48.2% African American, 41.5% non-Latino White, 5.4% Latino, and 4.9% other, and 57.6% reported a total annual household income < $30,000. The majority of participants were female (54...
May 23, 2016: Journal of Consulting and Clinical Psychology
Mia Hashibe, Sarah Abdelaziz, Mohammed Al-Temimi, Alison Fraser, Kenneth M Boucher, Ken Smith, Yuan-Chin Amy Lee, Kerry Rowe, Braden Rowley, Micky Daurelle, Avery E Holton, James VanDerslice, Lorenzo Richiardi, Jay Bishoff, Will Lowrance, Antoinette Stroup
PURPOSE: Testicular cancer is diagnosed at a young age and survival rates are high; thus, the long-term effects of cancer treatment need to be assessed. Our objectives are to estimate the incidence rates and determinants of late effects in testicular cancer survivors. METHODS: We conducted a population-based cohort study of testicular cancer survivors, diagnosed 1991-2007, followed up for a median of 10 years. We identified 785 testicular cancer patients who survived ≥5 years and 3323 men free of cancer for the comparison group...
May 11, 2016: Journal of Cancer Survivorship: Research and Practice
Micky D Tortorella, Yanmei Zhang, John Talley
Coxibs are a class of powerful drugs used by millions of people worldwide to treat a wide variety of ailments such as muscular skeletal pain and inflammation. The primary mechanism of action of coxibs is the potent inhibition of the COX-2 enzyme. Unfortunately, their use is limited to patients due to a variety of factors including poor solubility, negative effects on renal clearance and increased risk of cardiovascular pathology. However, because of their effectiveness in blocking PGE2 mediated inflammation, a key pathway that drives many diseases, there is a clear unmet medical need to develop new COX-2 inhibitors that are free of the aforementioned problems...
May 9, 2016: Mini Reviews in Medicinal Chemistry
Peter S Y Yu, Simon C H Yu, Cyrus T C Ng, Micky W T Kwok, Simon C Y Chow, Jacky Y K Ho, Malcolm J Underwood, Randolph H L Wong
A 57-year-old man was incidentally found to have a dissected diverticulum of Kommerell originating from aberrant origin of right subclavian artery during follow-up for treated colon cancer. A right carotid-axillary bypass was followed by embolization of aberrant artery and the diverticulum by deployment of multiple detachable coils using the Penumbra Ruby System (Penumbra, Alameda, CA). Angiography after embolization showed exclusion of flow to the aberrant artery and a patent right carotid-axillary bypass...
May 2016: Annals of Thoracic Surgery
John M Marshall, Mahamoudou Touré, André Lin Ouédraogo, Micky Ndhlovu, Samson S Kiware, Ashley Rezai, Emmy Nkhama, Jamie T Griffin, T Deirdre Hollingsworth, Seydou Doumbia, Nicodem J Govella, Neil M Ferguson, Azra C Ghani
BACKGROUND: As malaria prevalence declines in many parts of the world due to widescale control efforts and as drug-resistant parasites begin to emerge, a quantitative understanding of human movement is becoming increasingly relevant to malaria control. However, despite its importance, significant knowledge gaps remain regarding human movement, particularly in sub-Saharan Africa. METHODS: A quantitative survey of human movement patterns was conducted in four countries in sub-Saharan Africa: Mali, Burkina Faso, Zambia, and Tanzania, with three to five survey locations chosen in each country...
2016: Malaria Journal
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