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RANDOMIZED CONTROLLED TRIAL
Karim Ali, Tanweer Azher, Mahin Baqi, Alexandra Binnie, Sergio Borgia, François M Carrier, Yiorgos Alexandroa Cavayas, Nicolas Chagnon, Matthew P Cheng, John Conly, Cecilia Costiniuk, Peter Daley, Nick Daneman, Josh Douglas, Catarina Downey, Erick Duan, Emmanuelle Duceppe, Madeleine Durand, Shane English, George Farjou, Evradiki Fera, Patricia Fontela, Rob Fowler, Michael Fralick, Anna Geagea, Jennifer Grant, Luke B Harrison, Thomas Havey, Holly Hoang, Lauren E Kelly, Yoav Keynan, Kosar Khwaja, Gail Klein, Marina Klein, Christophe Kolan, Nadine Kronfli, Francois Lamontagne, Rob Lau, Michael Fralick, Todd C Lee, Nelson Lee, Rachel Lim, Sarah Longo, Alexandra Lostun, Erika MacIntyre, Isabelle Malhamé, Kathryn Mangof, Marlee McGuinty, Sonya Mergler, Matthew P Munan, Srinivas Murthy, Conar O'Neil, Daniel Ovakim, Jesse Papenburg, Ken Parhar, Seema Nair Parvathy, Chandni Patel, Santiago Perez-Patrigeon, Ruxandra Pinto, Subitha Rajakumaran, Asgar Rishu, Malaika Roba-Oshin, Moira Rushton, Mariam Saleem, Marina Salvadori, Kim Scherr, Kevin Schwartz, Makeda Semret, Michael Silverman, Ameeta Singh, Wendy Sligl, Stephanie Smith, Ranjani Somayaji, Darrell H S Tan, Siobhan Tobin, Meaghan Todd, Tuong-Vi Tran, Alain Tremblay, Jennifer Tsang, Alexis Turgeon, Erik Vakil, Jason Weatherald, Cedric Yansouni, Ryan Zarychanski
BACKGROUND: The role of remdesivir in the treatment of patients in hospital with COVID-19 remains ill defined in a global context. The World Health Organization Solidarity randomized controlled trial (RCT) evaluated remdesivir in patients across many countries, with Canada enrolling patients using an expanded data collection format in the Canadian Treatments for COVID-19 (CATCO) trial. We report on the Canadian findings, with additional demographics, characteristics and clinical outcomes, to explore the potential for differential effects across different health care systems...
February 22, 2022: Canadian Medical Association Journal: CMAJ
#22
Donnele Daley, Vishnu R Mani, Navyatha Mohan, Neha Akkad, Atsuo Ochi, Daniel W Heindel, Ki Buom Lee, Constantinos P Zambirinis, Gautam S D Balasubramania Pandian, Shivraj Savadkar, Alejandro Torres-Hernandez, Shruti Nayak, Ding Wang, Mautin Hundeyin, Brian Diskin, Berk Aykut, Gregor Werba, Rocky M Barilla, Robert Rodriguez, Steven Chang, Lawrence Gardner, Lara K Mahal, Beatrix Ueberheide, George Miller
No abstract text is available yet for this article.
December 2021: Nature Medicine
#23
JOURNAL ARTICLE
Joshua M Francis, Del Leistritz-Edwards, Augustine Dunn, Christina Tarr, Jesse Lehman, Conor Dempsey, Andrew Hamel, Violeta Rayon, Gang Liu, Yuntong Wang, Marcos Wille, Melissa Durkin, Kane Hadley, Aswathy Sheena, Benjamin Roscoe, Mark Ng, Graham Rockwell, Margaret Manto, Elizabeth Gienger, Joshua Nickerson, Amir Moarefi, Michael Noble, Thomas Malia, Philip D Bardwell, William Gordon, Joanna Swain, Mojca Skoberne, Karsten Sauer, Tim Harris, Ananda W Goldrath, Alex K Shalek, Anthony J Coyle, Christophe Benoist, Daniel C Pregibon
Effective presentation of antigens by human leukocyte antigen (HLA) class I molecules to CD8+ T cells is required for viral elimination and generation of long-term immunological memory. In this study, we applied a single-cell, multiomic technology to generate a unified ex vivo characterization of the CD8+ T cell response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) across four major HLA class I alleles. We found that HLA genotype conditions key features of epitope specificity, TCRα/β sequence diversity, and the utilization of pre-existing SARS-CoV-2-reactive memory T cell pools...
January 21, 2022: Science Immunology
#24
JOURNAL ARTICLE
Pavlos Missios, Edroaldo Lummertz da Rocha, Daniel S Pearson, Julia Philipp, Maria M Aleman, Mehdi Pirouz, Dorian Farache, Joseph W Franses, Caroline Kubaczka, Kaloyan M Tsanov, Deepak K Jha, Brian Pepe-Mooney, John T Powers, Richard I Gregory, Amy Sy Lee, Daniel Dominguez, David T Ting, George Q Daley
High expression of LIN28B is associated with aggressive malignancy and poor survival. Here, probing MYCN-amplified neuroblastoma as a model system, we showed that LIN28B expression was associated with enhanced cell migration in vitro and invasive and metastatic behavior in murine xenografts. Sequence analysis of the polyribosome fraction of LIN28B-expressing neuroblastoma cells revealed let-7-independent enrichment of transcripts encoding components of the translational and ribosomal apparatus and depletion of transcripts of neuronal developmental programs...
November 15, 2021: Journal of Clinical Investigation
#25
JOURNAL ARTICLE
Hua Yu, Zhen Sun, Tianyu Tan, Hongru Pan, Jing Zhao, Ling Zhang, Jiayu Chen, Anhua Lei, Yuqing Zhu, Lang Chen, Yuyan Xu, Yaxin Liu, Ming Chen, Jinghao Sheng, Zhengping Xu, Pengxu Qian, Cheng Li, Shaorong Gao, George Q Daley, Jin Zhang
The nucleolus is the organelle for ribosome biogenesis and sensing various types of stress. However, its role in regulating stem cell fate remains unclear. Here, we present evidence that nucleolar stress induced by interfering rRNA biogenesis can drive the 2-cell stage embryo-like (2C-like) program and induce an expanded 2C-like cell population in mouse embryonic stem (mES) cells. Mechanistically, nucleolar integrity maintains normal liquid-liquid phase separation (LLPS) of the nucleolus and the formation of peri-nucleolar heterochromatin (PNH)...
November 9, 2021: Nature Communications
#26
JOURNAL ARTICLE
Daniela Vera Cruz Dos Santos, Patrícia Coelho de Soárez, Victoria Cavero, Thaís I U Rocha, Suzana Aschar, Kate Louise Daley, Heloísa Garcia Claro, George Abud Scotton, Ivan Fernandes, Francisco Diez-Canseco, Lena Rebeca Brandt, Mauricio Toyama, Hellen Carolina Martins Castro, J Jaime Miranda, Ricardo Araya, Julieta Quayle, Paulo Rossi Menezes
BACKGROUND: Mobile health interventions provide significant strategies for improving access to health services, offering a potential solution to reduce the mental health treatment gap. Economic evaluation of this intervention is needed to help inform local mental health policy and program development. OBJECTIVE: This paper presents the protocol for an economic evaluation conducted alongside 2 randomized controlled trials (RCTs) to evaluate the cost-effectiveness of a psychological intervention delivered through a technological platform (CONEMO) to treat depressive symptoms in people with diabetes, hypertension, or both...
October 13, 2021: JMIR Research Protocols
#27
JOURNAL ARTICLE
Oncogenic switch and single-agent MET inhibitor sensitivity in a subset of EGFR -mutant lung cancer.
Pınar Özden Eser, Raymond M Paranal, Jieun Son, Elena Ivanova, Yanan Kuang, Heidi M Haikala, Ciric To, Jeffrey J Okoro, Kshiti H Dholakia, Jihyun Choi, Yoonji Eum, Atsuko Ogino, Pavlos Missios, Dalia Ercan, Man Xu, Michael J Poitras, Stephen Wang, Kenneth Ngo, Michael Dills, Masahiko Yanagita, Timothy Lopez, Mika Lin, Jeanelle Tsai, Nicolas Floch, Emily S Chambers, Jennifer Heng, Rana Anjum, Alison D Santucci, Kesi Michael, Alwin G Schuller, Darren Cross, Paul D Smith, Geoffrey R Oxnard, David A Barbie, Lynette M Sholl, Magda Bahcall, Sangeetha Palakurthi, Prafulla C Gokhale, Cloud P Paweletz, George Q Daley, Pasi A Jänne
[Figure: see text].
September 2021: Science Translational Medicine
#28
JOURNAL ARTICLE
Laila F Ibrahim, Doris Tham, Vimuthi Chong, Mark Corden, Simon Craig, Paul Buntine, Shefali Jani, Michael Zhang, Shane George, Amit Kochar, Sharon O'Brien, Karen Robins-Browne, Shidan Tosif, Andrew Daley, Sarah McNab, Nigel W Crawford, Catherine Wilson, Franz E Babl
OBJECTIVES: To examine the epidemiological and clinical characteristics of SARS-CoV-2-positive children in Australia during 2020. DESIGN, SETTING: Multicentre retrospective study in 16 hospitals of the Paediatric Research in Emergency Departments International Collaborative (PREDICT) network; eleven in Victoria, five in four other Australian states. PARTICIPANTS: Children aged 0-17 years who presented to hospital-based COVID-19 testing clinics, hospital wards, or emergency departments during 1 February - 30 September 2020 and who were positive for SARS-CoV-2...
August 13, 2021: Medical Journal of Australia
#29
EDITORIAL
Mohamed Abou-El-Enein, Aris Angelis, Frederick R Appelbaum, Nancy C Andrews, Susan E Bates, Arlene S Bierman, Malcolm K Brenner, Marina Cavazzana, Michael A Caligiuri, Hans Clevers, Emer Cooke, George Q Daley, Victor J Dzau, Lee M Ellis, Harvey V Fineberg, Lawrence S B Goldstein, Stephen Gottschalk, Margaret A Hamburg, Donald E Ingber, Donald B Kohn, Adrian R Krainer, Marcela V Maus, Peter Marks, Christine L Mummery, Roderic I Pettigrew, Joni L Rutter, Sarah A Teichmann, Andre Terzic, Fyodor D Urnov, David A Williams, Jedd D Wolchok, Mark Lawler, Cameron J Turtle, Gerhard Bauer, John P A Ioannidis
No abstract text is available yet for this article.
September 10, 2021: Molecular Therapy. Methods & Clinical Development
#30
JOURNAL ARTICLE
Zhen Sun, Hua Yu, Jing Zhao, Tianyu Tan, Hongru Pan, Yuqing Zhu, Lang Chen, Cheng Zhang, Li Zhang, Anhua Lei, Yuyan Xu, Xianju Bi, Xin Huang, Bo Gao, Longfei Wang, Cristina Correia, Ming Chen, Qiming Sun, Yu Feng, Li Shen, Hao Wu, Jianlong Wang, Xiaohua Shen, George Q Daley, Hu Li, Jin Zhang
LIN28 is an RNA binding protein with important roles in early embryo development, stem cell differentiation/reprogramming, tumorigenesis and metabolism. Previous studies have focused mainly on its role in the cytosol where it interacts with Let-7 microRNA precursors or mRNAs, and few have addressed LIN28's role within the nucleus. Here, we show that LIN28 displays dynamic temporal and spatial expression during murine embryo development. Maternal LIN28 expression drops upon exit from the 2-cell stage, and zygotic LIN28 protein is induced at the forming nucleolus during 4-cell to blastocyst stage development, to become dominantly expressed in the cytosol after implantation...
July 2022: Protein & Cell
#31
JOURNAL ARTICLE
Jihan K Osborne, Melissa A Kinney, Areum Han, Kemi E Akinnola, Alena V Yermalovich, Linda T Vo, Daniel S Pearson, Patricia M Sousa, Sutheera Ratanasirintrawoot, Kaloyan M Tsanov, Jessica Barragan, Trista E North, Ross J Metzger, George Q Daley
The molecular mechanisms that govern the choreographed timing of organ development remain poorly understood. Our investigation of the role of the Lin28a and Lin28b paralogs during the developmental process of branching morphogenesis establishes that dysregulation of Lin28a/b leads to abnormal branching morphogenesis in the lung and other tissues. Additionally, we find that the Lin28 paralogs, which regulate post-transcriptional processing of both mRNAs and microRNAs (miRNAs), predominantly control mRNAs during the initial phases of lung organogenesis...
July 20, 2021: Cell Reports
#32
JOURNAL ARTICLE
Thomas Barthlott, Adam E Handel, Hong Ying Teh, Rushika C Wirasinha, Katrin Hafen, Saulius Žuklys, Benoit Roch, Stuart H Orkin, Jean-Pierre de Villartay, Stephen R Daley, Georg A Holländer
Thymic T cell development and T cell receptor repertoire selection are dependent on essential molecular cues provided by thymic epithelial cells (TEC). TEC development and function are regulated by their epigenetic landscape, in which the repressive H3K27me3 epigenetic marks are catalyzed by polycomb repressive complex 2 (PRC2). Here we show that a TEC-targeted deficiency of PRC2 function results in a hypoplastic thymus with reduced ability to express antigens and select a normal repertoire of T cells. The absence of PRC2 activity reveals a transcriptomically distinct medullary TEC lineage that incompletely off-sets the shortage of canonically-derived medullary TEC whereas cortical TEC numbers remain unchanged...
June 24, 2021: Nature Communications
#33
JOURNAL ARTICLE
Rebecca A Soto, Mohamad Ali T Najia, Mariam Hachimi, Jenna M Frame, Gabriel A Yette, Edroaldo Lummertz da Rocha, Kryn Stankunas, George Q Daley, Trista E North
Across species, hematopoietic stem and progenitor cells (HSPCs) arise during embryogenesis from a specialized arterial population, termed hemogenic endothelium. Here, we describe a mechanistic role for the epigenetic regulator, Enhancer of zeste homolog-1 (Ezh1), in vertebrate HSPC production via regulation of hemogenic commitment. Loss of ezh1 in zebrafish embryos favored acquisition of hemogenic (gata2b) and HSPC (runx1) fate at the expense of the arterial program (ephrinb2a, dll4). In contrast, ezh1 overexpression blocked hematopoietic progression via maintenance of arterial gene expression...
July 13, 2021: Stem Cell Reports
#34
JOURNAL ARTICLE
David C Nguyen, Khalid M Dousa, Sebastian G Kurz, Sheldon T Brown, George Drusano, Steven M Holland, Barry N Kreiswirth, W Henry Boom, Charles L Daley, Robert A Bonomo
Mycobacterium abscessus subsp. abscessus is one of the most difficult pathogens to treat and its incidence in disease is increasing. Dual β-lactam combinations act synergistically in vitro but are not widely employed in practice. A recent study shows that a combination of imipenem and ceftaroline significantly lowers the minimum inhibitory concentration of clinical isolates, despite both drugs targeting the same peptidoglycan synthesis enzymes. The underlying mechanism of this effect provides a basis for further investigations of dual β-lactam combinations in the treatment of M...
October 20, 2021: Clinical Infectious Diseases
#35
REVIEW
Robin Lovell-Badge, Eric Anthony, Roger A Barker, Tania Bubela, Ali H Brivanlou, Melissa Carpenter, R Alta Charo, Amander Clark, Ellen Clayton, Yali Cong, George Q Daley, Jianping Fu, Misao Fujita, Andy Greenfield, Steve A Goldman, Lori Hill, Insoo Hyun, Rosario Isasi, Jeffrey Kahn, Kazuto Kato, Jin-Soo Kim, Jonathan Kimmelman, Jürgen A Knoblich, Debra Mathews, Nuria Montserrat, Jack Mosher, Megan Munsie, Hiromitsu Nakauchi, Luigi Naldini, Gail Naughton, Kathy Niakan, Ubaka Ogbogu, Roger Pedersen, Nicolas Rivron, Heather Rooke, Janet Rossant, Jeff Round, Mitinori Saitou, Douglas Sipp, Julie Steffann, Jeremy Sugarman, Azim Surani, Jun Takahashi, Fuchou Tang, Leigh Turner, Patricia J Zettler, Xiaomei Zhai
The International Society for Stem Cell Research has updated its Guidelines for Stem Cell Research and Clinical Translation in order to address advances in stem cell science and other relevant fields, together with the associated ethical, social, and policy issues that have arisen since the last update in 2016. While growing to encompass the evolving science, clinical applications of stem cells, and the increasingly complex implications of stem cell research for society, the basic principles underlying the Guidelines remain unchanged, and they will continue to serve as the standard for the field and as a resource for scientists, regulators, funders, physicians, and members of the public, including patients...
June 8, 2021: Stem Cell Reports
#36
JOURNAL ARTICLE
Terrence S Daley-Lindo, Matt Kerr, George J Haidukewych, Kenneth J Koval, Joshua A Parry, Joshua R Langford
Background: Suprapatellar nailing of tibial fractures has not been shown to affect short-term knee outcomes, however long-term outcomes are unknown. The purpose of this study was to report long-term patient-reported knee outcomes after suprapatellar nailing. Methods: Thirty-five adult patients with 37 tibial shaft fractures treated with suprapatellar nailing completed the Tegner-Lysholm Knee Score (TLKS) at an average of 5 years (range, 4-9 years) follow-up. Results: The median TLKS was 98 (interquartile range, 85-100): Scores were considered excellent in 24 (68%), good in 3 (9%), fair in 3 (9%), and poor in 5 (14%)...
June 2021: Indian Journal of Orthopaedics
#37
RANDOMIZED CONTROLLED TRIAL
Ricardo Araya, Paulo Rossi Menezes, Heloísa Garcia Claro, Lena R Brandt, Kate L Daley, Julieta Quayle, Francisco Diez-Canseco, Tim J Peters, Daniela Vera Cruz, Mauricio Toyama, Suzana Aschar, Liliana Hidalgo-Padilla, Hellen Martins, Victoria Cavero, Thais Rocha, George Scotton, Ivan F de Almeida Lopes, Mark Begale, David C Mohr, J Jaime Miranda
Importance: Depression is a leading contributor to disease burden globally. Digital mental health interventions can address the treatment gap in low- and middle-income countries, but the effectiveness in these countries is unknown. Objective: To investigate the effectiveness of a digital intervention in reducing depressive symptoms among people with diabetes and/or hypertension. Design, Setting, and Participants: Participants with clinically significant depressive symptoms (Patient Health Questionnaire-9 [PHQ-9] score ≥10) who were being treated for hypertension and/or diabetes were enrolled in a cluster randomized clinical trial (RCT) at 20 sites in São Paulo, Brazil (N=880; from September 2016 to September 2017; final follow-up, April 2018), and in an individual-level RCT at 7 sites in Lima, Peru (N=432; from January 2017 to September 2017; final follow-up, March 2018)...
May 11, 2021: JAMA
#38
JOURNAL ARTICLE
Annabeth P Groenman, Rianne Hornstra, Pieter J Hoekstra, Laura Steenhuis, Asma Aghebati, Bianca E Boyer, Jan K Buitelaar, Andrea Chronis-Tuscano, David Daley, Parisa Dehkordian, Melissa Dvorsky, Nike Franke, George J DuPaul, Naama Gershy, Elizabeth Harvey, Timo Hennig, Sharonne Herbert, Joshua Langberg, Jennifer A Mautone, Amori Yee Mikami, Linda J Pfiffner, Thomas J Power, Sijmen A Reijneveld, Satyam Antonio Schramm, Julie B Schweitzer, Margaret H Sibley, Edmund Sonuga-Barke, Catharine Thompson, Margaret Thompson, Carolyn Webster-Stratton, Yuhuan Xie, Marjolein Luman, Saskia van der Oord, Barbara J van den Hoofdakker
OBJECTIVE: Behavioral interventions are well established treatments for children with attention-deficit/hyperactivity disorder (ADHD). However, insight into moderators of treatment outcome is limited. METHOD: We conducted an individual participant data meta-analysis (IPDMA), including data of randomized controlled behavioral intervention trials for individuals with ADHD <18 years of age. Outcomes were symptoms of ADHD, oppositional defiant disorder (ODD), and conduct disorder (CD) and impairment...
February 2022: Journal of the American Academy of Child and Adolescent Psychiatry
#39
Lena Seifert, Gregor Werba, Shaun Tiwari, Nancy Ngoc Giao Ly, Sara Alothman, Dalia Alqunaibit, Antonina Avanzi, Rocky Barilla, Donnele Daley, Stephanie H Greco, Alejandro Torres-Hernandez, Matthew Pergamo, Atsuo Ochi, Constantinos P Zambirinis, Mridul Pansari, Mauricio Rendon, Daniel Tippens, Mautin Hundeyin, Vishnu R Mani, Cristina Hajdu, Dannielle Engle, George Miller
No abstract text is available yet for this article.
March 11, 2021: Nature
#40
James S Clark, Robert Andrus, Melaine Aubry-Kientz, Yves Bergeron, Michal Bogdziewicz, Don C Bragg, Dale Brockway, Natalie L Cleavitt, Susan Cohen, Benoit Courbaud, Robert Daley, Adrian J Das, Michael Dietze, Timothy J Fahey, Istem Fer, Jerry F Franklin, Catherine A Gehring, Gregory S Gilbert, Cathryn H Greenberg, Qinfeng Guo, Janneke HilleRisLambers, Ines Ibanez, Jill Johnstone, Christopher L Kilner, Johannes Knops, Walter D Koenig, Georges Kunstler, Jalene M LaMontagne, Kristin L Legg, Jordan Luongo, James A Lutz, Diana Macias, Eliot J B McIntire, Yassine Messaoud, Christopher M Moore, Emily Moran, Jonathan A Myers, Orrin B Myers, Chase Nunez, Robert Parmenter, Sam Pearse, Scott Pearson, Renata Poulton-Kamakura, Ethan Ready, Miranda D Redmond, Chantal D Reid, Kyle C Rodman, C Lane Scher, William H Schlesinger, Amanda M Schwantes, Erin Shanahan, Shubhi Sharma, Michael A Steele, Nathan L Stephenson, Samantha Sutton, Jennifer J Swenson, Margaret Swift, Thomas T Veblen, Amy V Whipple, Thomas G Whitham, Andreas P Wion, Kai Zhu, Roman Zlotin
No abstract text is available yet for this article.
March 8, 2021: Nature Communications
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