Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#1
JOURNAL ARTICLE
Reyna Hernandez-Benitez, Chao Wang, Lei Shi, Yasuo Ouchi, Cuiqing Zhong, Tomoaki Hishida, Hsin-Kai Liao, Eric A Magill, Sebastian Memczak, Rupa D Soligalla, Chiara Fresia, Fumiyuki Hatanaka, Veronica Lamas, Isabel Guillen, Sanjeeb Sahu, Mako Yamamoto, Yanjiao Shao, Alain Aguirre-Vazquez, Estrella Nuñez Delicado, Pedro Guillen, Concepcion Rodriguez Esteban, Jing Qu, Pradeep Reddy, Steve Horvath, Guang-Hui Liu, Pierre Magistretti, Juan Carlos Izpisua Belmonte
Tissue regeneration following an injury requires dynamic cell-state transitions that allow for establishing the cell identities required for the restoration of tissue homeostasis and function. Here, we present a biochemical intervention that induces an intermediate cell state mirroring a transition identified during normal differentiation of myoblasts and other multipotent and pluripotent cells to mature cells. When applied in somatic differentiated cells, the intervention, composed of one-carbon metabolites, reduces some dedifferentiation markers without losing the lineage identity, thus inducing limited reprogramming into a more flexible cell state...
March 19, 2024: Cell reports medicine
#2
JOURNAL ARTICLE
Qiaoran Wang, Xuebao Wang, Beibei Liu, Shuai Ma, Feng Zhang, Shuhui Sun, Yaobin Jing, Yanling Fan, Yingjie Ding, Muzhao Xiong, Jiaming Li, Qiaocheng Zhai, Yandong Zheng, Chengyu Liu, Gang Xu, Jiayin Yang, Si Wang, Jinlin Ye, Juan Carlos Izpisua Belmonte, Jing Qu, Guang-Hui Liu, Weiqi Zhang
Adrenal glands, vital for steroid secretion and the regulation of metabolism, stress responses and immune activation, experience age-related decline, impacting systemic health. However, the regulatory mechanisms underlying adrenal aging remain largely uninvestigated. Here we established a single-nucleus transcriptomic atlas of both young and aged primate suprarenal glands, identifying lipid metabolism and steroidogenic pathways as core processes impacted by aging. We found dysregulation in centripetal adrenocortical differentiation in aged adrenal tissues and cells in the zona reticularis region, responsible for producing dehydroepiandrosterone sulfate (DHEA-S), were highly susceptible to aging, reflected by senescence, exhaustion and disturbed hormone production...
March 2024: Nature aging
#3
JOURNAL ARTICLE
Shijia Bi, Xiaoyu Jiang, Qianzhao Ji, Zehua Wang, Jie Ren, Si Wang, Yang Yu, Ruoqi Wang, Zunpeng Liu, Junhang Liu, Jianli Hu, Guoqiang Sun, Zeming Wu, Zhiqing Diao, Jingyi Li, Liang Sun, Juan Carlos Izpisua Belmonte, Weiqi Zhang, Guang-Hui Liu, Jing Qu
Sirtuins are pro-longevity genes with chromatin modulation potential, but how these properties are connected is not well understood. Here, we generated a panel of isogeneic human stem cell lines with SIRT1-SIRT7 knockouts and found that any sirtuin deficiency leads to accelerated cellular senescence. Through large-scale epigenomic analyses, we show how sirtuin deficiency alters genome organization and that genomic regions sensitive to sirtuin deficiency are preferentially enriched in active enhancers, thereby promoting interactions within topologically associated domains and the formation of de novo enhancer-promoter loops...
March 11, 2024: Developmental Cell
#4
JOURNAL ARTICLE
Meng Liu, Chao Zhang, Ximing Gong, Tian Zhang, Michelle Mulan Lian, Elaine Guo Yan Chew, Angelysia Cardilla, Keiichiro Suzuki, Huamin Wang, Yuan Yuan, Yan Li, Mihir Yogesh Naik, Yixuan Wang, Bingrui Zhou, Wei Ze Soon, Emi Aizawa, Pin Li, Jian Hui Low, Moses Tandiono, Enrique Montagud, Daniel Moya-Rull, Concepcion Rodriguez Esteban, Yosu Luque, Mingliang Fang, Chiea Chuen Khor, Nuria Montserrat, Josep M Campistol, Juan Carlos Izpisua Belmonte, Jia Nee Foo, Yun Xia
Human pluripotent stem cell-derived kidney organoids offer unprecedented opportunities for studying polycystic kidney disease (PKD), which still has no effective cure. Here, we developed both in vitro and in vivo organoid models of PKD that manifested tubular injury and aberrant upregulation of renin-angiotensin aldosterone system. Single-cell analysis revealed that a myriad of metabolic changes occurred during cystogenesis, including defective autophagy. Experimental activation of autophagy via ATG5 overexpression or primary cilia ablation significantly inhibited cystogenesis in PKD kidney organoids...
January 4, 2024: Cell Stem Cell
#5
JOURNAL ARTICLE
Kaowen Yan, Qianzhao Ji, Dongxin Zhao, Mingheng Li, Xiaoyan Sun, Zehua Wang, Xiaoqian Liu, Zunpeng Liu, Hongyu Li, Yingjie Ding, Si Wang, Juan Carlos Izpisua Belmonte, Jing Qu, Weiqi Zhang, Guang-Hui Liu
Phase separation, a biophysical segregation of subcellular milieus referred as condensates, is known to regulate transcription, but its impacts on physiological processes are less clear. Here, we demonstrate the formation of liquid-like nuclear condensates by SGF29, a component of the SAGA transcriptional coactivator complex, during cellular senescence in human mesenchymal progenitor cells (hMPCs) and fibroblasts. The Arg 207 within the intrinsically disordered region is identified as the key amino acid residue for SGF29 to form phase separation...
November 7, 2023: Cell Discovery
#6
Hui Zhang, Jiaming Li, Yang Yu, Jie Ren, Qiang Liu, Zhaoshi Bao, Shuhui Sun, Xiaoqian Liu, Shuai Ma, Zunpeng Liu, Kaowen Yan, Zeming Wu, Yanling Fan, Xiaoyan Sun, Yixin Zhang, Qianzhao Ji, Fang Cheng, Peng-Hu Wei, Xibo Ma, Shiqiang Zhang, Zhengwei Xie, Yuyu Niu, Yan-Jiang Wang, Jing-Dong J Han, Tao Jiang, Guoguang Zhao, Weizhi Ji, Juan Carlos Izpisua Belmonte, Si Wang, Jing Qu, Weiqi Zhang, Guang-Hui Liu
No abstract text is available yet for this article.
October 31, 2023: Cell Reports
#7
JOURNAL ARTICLE
Shuhui Sun, Jiaming Li, Si Wang, Jingyi Li, Jie Ren, Zhaoshi Bao, Le Sun, Xibo Ma, Fangshuo Zheng, Shuai Ma, Liang Sun, Min Wang, Yan Yu, Miyang Ma, Qiaoran Wang, Zhiyuan Chen, He Ma, Xuebao Wang, Zeming Wu, Hui Zhang, Kaowen Yan, Yuanhan Yang, Yixin Zhang, Sheng Zhang, Jinghui Lei, Zhao-Qian Teng, Chang-Mei Liu, Ge Bai, Yan-Jiang Wang, Jian Li, Xiaoqun Wang, Guoguang Zhao, Tao Jiang, Juan Carlos Izpisua Belmonte, Jing Qu, Weiqi Zhang, Guang-Hui Liu
Aging is a critical factor in spinal cord-associated disorders1 , yet aging-specific mechanisms underlying this relationship remain poorly understood. To address this knowledge gap, we combined single-nucleus RNA sequencing with behavioral and neurophysiological analysis in non-human primates (NHPs). We identified motor neuron senescence and neuroinflammation with microglial hyperactivation as intertwined hallmarks of spinal cord aging. As an underlying mechanism, we identified a previously unreported neurotoxic microglial state demarcated by elevated expression of CHIT1 (a secreted mammalian chitinase) specific to the aged spinal cords in NHP and human biopsies...
October 31, 2023: Nature
#8
JOURNAL ARTICLE
Yusheng Cai, Muzhao Xiong, Zijuan Xin, Chengyu Liu, Jie Ren, Xiying Yang, Jinghui Lei, Wei Li, Feifei Liu, Qun Chu, Yiyuan Zhang, Jian Yin, Yanxia Ye, Dingyi Liu, Yanling Fan, Shuhui Sun, Yaobin Jing, Qian Zhao, Liyun Zhao, Shanshan Che, Yandong Zheng, Haoteng Yan, Shuai Ma, Si Wang, Juan Carlos Izpisua Belmonte, Jing Qu, Weiqi Zhang, Guang-Hui Liu
Regeneration across tissues and organs exhibits significant variation throughout the body and undergoes a progressive decline with age. To decode the relationships between aging and regenerative capacity, we conducted a comprehensive single-cell transcriptome analysis of regeneration in eight tissues from young and aged mice. We employed diverse analytical models to study tissue regeneration and unveiled the intricate cellular and molecular mechanisms underlying the attenuated regenerative processes observed in aged tissues...
December 7, 2023: Cell Stem Cell
#9
JOURNAL ARTICLE
Yaobin Jing, Xiaoyu Jiang, Qianzhao Ji, Zeming Wu, Wei Wang, Zunpeng Liu, Pedro Guillen-Garcia, Concepcion Rodriguez Esteban, Pradeep Reddy, Steve Horvath, Jingyi Li, Lingling Geng, Qinchao Hu, Si Wang, Juan Carlos Izpisua Belmonte, Jie Ren, Weiqi Zhang, Jing Qu, Guang-Hui Liu
Our understanding of the molecular basis for cellular senescence remains incomplete, limiting the development of strategies to ameliorate age-related pathologies by preventing stem cell senescence. Here, we performed a genome-wide CRISPR activation (CRISPRa) screening using a human mesenchymal precursor cell (hMPC) model of the progeroid syndrome. We evaluated targets whose activation antagonizes cellular senescence, among which SOX5 outperformed as a top hit. Through decoding the epigenomic landscapes remodeled by overexpressing SOX5, we uncovered its role in resetting the transcription network for geroprotective genes, including HMGB2...
November 2, 2023: Cell Stem Cell
#10
JOURNAL ARTICLE
Yanxia Ye, Kuan Yang, Haisong Liu, Yang Yu, Moshi Song, Daoyuan Huang, Jinghui Lei, Yiyuan Zhang, Zunpeng Liu, Qun Chu, Yanling Fan, Sheng Zhang, Yaobin Jing, Concepcion Rodriguez Esteban, Si Wang, Juan Carlos Izpisua Belmonte, Jing Qu, Weiqi Zhang, Guang-Hui Liu
Aging is a major risk factor contributing to pathophysiological changes in the heart, yet its intrinsic mechanisms have been largely unexplored in primates. In this study, we investigated the hypertrophic and senescence phenotypes in the hearts of aged cynomolgus monkeys as well as the transcriptomic and proteomic landscapes of young and aged primate hearts. SIRT2 was identified as a key protein decreased in aged monkey hearts, and engineered SIRT2 deficiency in human pluripotent stem cell-derived cardiomyocytes recapitulated key senescence features of primate heart aging...
October 2023: Nature aging
#11
A T Lu, Z Fei, A Haghani, T R Robeck, J A Zoller, C Z Li, R Lowe, Q Yan, J Zhang, H Vu, J Ablaeva, V A Acosta-Rodriguez, D M Adams, J Almunia, A Aloysius, R Ardehali, A Arneson, C S Baker, G Banks, K Belov, N C Bennett, P Black, D T Blumstein, E K Bors, C E Breeze, R T Brooke, J L Brown, G G Carter, A Caulton, J M Cavin, L Chakrabarti, I Chatzistamou, H Chen, K Cheng, P Chiavellini, O W Choi, S M Clarke, L N Cooper, M L Cossette, J Day, J DeYoung, S DiRocco, C Dold, E E Ehmke, C K Emmons, S Emmrich, E Erbay, C Erlacher-Reid, C G Faulkes, S H Ferguson, C J Finno, J E Flower, J M Gaillard, E Garde, L Gerber, V N Gladyshev, V Gorbunova, R G Goya, M J Grant, C B Green, E N Hales, M B Hanson, D W Hart, M Haulena, K Herrick, A N Hogan, C J Hogg, T A Hore, T Huang, J C Izpisua Belmonte, A J Jasinska, G Jones, E Jourdain, O Kashpur, H Katcher, E Katsumata, V Kaza, H Kiaris, M S Kobor, P Kordowitzki, W R Koski, M Krützen, S B Kwon, B Larison, S G Lee, M Lehmann, J F Lemaitre, A J Levine, C Li, X Li, A R Lim, D T S Lin, D M Lindemann, T J Little, N Macoretta, D Maddox, C O Matkin, J A Mattison, M McClure, J Mergl, J J Meudt, G A Montano, K Mozhui, J Munshi-South, A Naderi, M Nagy, P Narayan, P W Nathanielsz, N B Nguyen, C Niehrs, J K O'Brien, P O'Tierney Ginn, D T Odom, A G Ophir, S Osborn, E A Ostrander, K M Parsons, K C Paul, M Pellegrini, K J Peters, A B Pedersen, J L Petersen, D W Pietersen, G M Pinho, J Plassais, J R Poganik, N A Prado, P Reddy, B Rey, B R Ritz, J Robbins, M Rodriguez, J Russell, E Rydkina, L L Sailer, A B Salmon, A Sanghavi, K M Schachtschneider, D Schmitt, T Schmitt, L Schomacher, L B Schook, K E Sears, A W Seifert, A Seluanov, A B A Shafer, D Shanmuganayagam, A V Shindyapina, M Simmons, K Singh, I Sinha, J Slone, R G Snell, E Soltanmaohammadi, M L Spangler, M C Spriggs, L Staggs, N Stedman, K J Steinman, D T Stewart, V J Sugrue, B Szladovits, J S Takahashi, M Takasugi, E C Teeling, M J Thompson, B Van Bonn, S C Vernes, D Villar, H V Vinters, M C Wallingford, N Wang, R K Wayne, G S Wilkinson, C K Williams, R W Williams, X W Yang, M Yao, B G Young, B Zhang, Z Zhang, P Zhao, Y Zhao, W Zhou, J Zimmermann, J Ernst, K Raj, S Horvath
No abstract text is available yet for this article.
September 6, 2023: Nature aging
#12
JOURNAL ARTICLE
A T Lu, Z Fei, A Haghani, T R Robeck, J A Zoller, C Z Li, R Lowe, Q Yan, J Zhang, H Vu, J Ablaeva, V A Acosta-Rodriguez, D M Adams, J Almunia, A Aloysius, R Ardehali, A Arneson, C S Baker, G Banks, K Belov, N C Bennett, P Black, D T Blumstein, E K Bors, C E Breeze, R T Brooke, J L Brown, G G Carter, A Caulton, J M Cavin, L Chakrabarti, I Chatzistamou, H Chen, K Cheng, P Chiavellini, O W Choi, S M Clarke, L N Cooper, M L Cossette, J Day, J DeYoung, S DiRocco, C Dold, E E Ehmke, C K Emmons, S Emmrich, E Erbay, C Erlacher-Reid, C G Faulkes, S H Ferguson, C J Finno, J E Flower, J M Gaillard, E Garde, L Gerber, V N Gladyshev, V Gorbunova, R G Goya, M J Grant, C B Green, E N Hales, M B Hanson, D W Hart, M Haulena, K Herrick, A N Hogan, C J Hogg, T A Hore, T Huang, J C Izpisua Belmonte, A J Jasinska, G Jones, E Jourdain, O Kashpur, H Katcher, E Katsumata, V Kaza, H Kiaris, M S Kobor, P Kordowitzki, W R Koski, M Krützen, S B Kwon, B Larison, S G Lee, M Lehmann, J F Lemaitre, A J Levine, C Li, X Li, A R Lim, D T S Lin, D M Lindemann, T J Little, N Macoretta, D Maddox, C O Matkin, J A Mattison, M McClure, J Mergl, J J Meudt, G A Montano, K Mozhui, J Munshi-South, A Naderi, M Nagy, P Narayan, P W Nathanielsz, N B Nguyen, C Niehrs, J K O'Brien, P O'Tierney Ginn, D T Odom, A G Ophir, S Osborn, E A Ostrander, K M Parsons, K C Paul, M Pellegrini, K J Peters, A B Pedersen, J L Petersen, D W Pietersen, G M Pinho, J Plassais, J R Poganik, N A Prado, P Reddy, B Rey, B R Ritz, J Robbins, M Rodriguez, J Russell, E Rydkina, L L Sailer, A B Salmon, A Sanghavi, K M Schachtschneider, D Schmitt, T Schmitt, L Schomacher, L B Schook, K E Sears, A W Seifert, A Seluanov, A B A Shafer, D Shanmuganayagam, A V Shindyapina, M Simmons, K Singh, I Sinha, J Slone, R G Snell, E Soltanmaohammadi, M L Spangler, M C Spriggs, L Staggs, N Stedman, K J Steinman, D T Stewart, V J Sugrue, B Szladovits, J S Takahashi, M Takasugi, E C Teeling, M J Thompson, B Van Bonn, S C Vernes, D Villar, H V Vinters, M C Wallingford, N Wang, R K Wayne, G S Wilkinson, C K Williams, R W Williams, X W Yang, M Yao, B G Young, B Zhang, Z Zhang, P Zhao, Y Zhao, W Zhou, J Zimmermann, J Ernst, K Raj, S Horvath
Aging, often considered a result of random cellular damage, can be accurately estimated using DNA methylation profiles, the foundation of pan-tissue epigenetic clocks. Here, we demonstrate the development of universal pan-mammalian clocks, using 11,754 methylation arrays from our Mammalian Methylation Consortium, which encompass 59 tissue types across 185 mammalian species. These predictive models estimate mammalian tissue age with high accuracy (r > 0.96). Age deviations correlate with human mortality risk, mouse somatotropic axis mutations and caloric restriction...
September 2023: Nature aging
#13
JOURNAL ARTICLE
Amin Haghani, Caesar Z Li, Todd R Robeck, Joshua Zhang, Ake T Lu, Julia Ablaeva, Victoria A Acosta-Rodríguez, Danielle M Adams, Abdulaziz N Alagaili, Javier Almunia, Ajoy Aloysius, Nabil M S Amor, Reza Ardehali, Adriana Arneson, C Scott Baker, Gareth Banks, Katherine Belov, Nigel C Bennett, Peter Black, Daniel T Blumstein, Eleanor K Bors, Charles E Breeze, Robert T Brooke, Janine L Brown, Gerald Carter, Alex Caulton, Julie M Cavin, Lisa Chakrabarti, Ioulia Chatzistamou, Andreas S Chavez, Hao Chen, Kaiyang Cheng, Priscila Chiavellini, Oi-Wa Choi, Shannon Clarke, Joseph A Cook, Lisa N Cooper, Marie-Laurence Cossette, Joanna Day, Joseph DeYoung, Stacy Dirocco, Christopher Dold, Jonathan L Dunnum, Erin E Ehmke, Candice K Emmons, Stephan Emmrich, Ebru Erbay, Claire Erlacher-Reid, Chris G Faulkes, Zhe Fei, Steven H Ferguson, Carrie J Finno, Jennifer E Flower, Jean-Michel Gaillard, Eva Garde, Livia Gerber, Vadim N Gladyshev, Rodolfo G Goya, Matthew J Grant, Carla B Green, M Bradley Hanson, Daniel W Hart, Martin Haulena, Kelsey Herrick, Andrew N Hogan, Carolyn J Hogg, Timothy A Hore, Taosheng Huang, Juan Carlos Izpisua Belmonte, Anna J Jasinska, Gareth Jones, Eve Jourdain, Olga Kashpur, Harold Katcher, Etsuko Katsumata, Vimala Kaza, Hippokratis Kiaris, Michael S Kobor, Pawel Kordowitzki, William R Koski, Michael Krützen, Soo Bin Kwon, Brenda Larison, Sang-Goo Lee, Marianne Lehmann, Jean-François Lemaître, Andrew J Levine, Xinmin Li, Cun Li, Andrea R Lim, David T S Lin, Dana M Lindemann, Schuyler W Liphardt, Thomas J Little, Nicholas Macoretta, Dewey Maddox, Craig O Matkin, Julie A Mattison, Matthew McClure, June Mergl, Jennifer J Meudt, Gisele A Montano, Khyobeni Mozhui, Jason Munshi-South, William J Murphy, Asieh Naderi, Martina Nagy, Pritika Narayan, Peter W Nathanielsz, Ngoc B Nguyen, Christof Niehrs, Batsaikhan Nyamsuren, Justine K O'Brien, Perrie O'Tierney Ginn, Duncan T Odom, Alexander G Ophir, Steve Osborn, Elaine A Ostrander, Kim M Parsons, Kimberly C Paul, Amy B Pedersen, Matteo Pellegrini, Katharina J Peters, Jessica L Petersen, Darren W Pietersen, Gabriela M Pinho, Jocelyn Plassais, Jesse R Poganik, Natalia A Prado, Pradeep Reddy, Benjamin Rey, Beate R Ritz, Jooke Robbins, Magdalena Rodriguez, Jennifer Russell, Elena Rydkina, Lindsay L Sailer, Adam B Salmon, Akshay Sanghavi, Kyle M Schachtschneider, Dennis Schmitt, Todd Schmitt, Lars Schomacher, Lawrence B Schook, Karen E Sears, Ashley W Seifert, Aaron B A Shafer, Anastasia V Shindyapina, Melanie Simmons, Kavita Singh, Ishani Sinha, Jesse Slone, Russel G Snell, Elham Soltanmohammadi, Matthew L Spangler, Maria Spriggs, Lydia Staggs, Nancy Stedman, Karen J Steinman, Donald T Stewart, Victoria J Sugrue, Balazs Szladovits, Joseph S Takahashi, Masaki Takasugi, Emma C Teeling, Michael J Thompson, Bill Van Bonn, Sonja C Vernes, Diego Villar, Harry V Vinters, Ha Vu, Mary C Wallingford, Nan Wang, Gerald S Wilkinson, Robert W Williams, Qi Yan, Mingjia Yao, Brent G Young, Bohan Zhang, Zhihui Zhang, Yang Zhao, Peng Zhao, Wanding Zhou, Joseph A Zoller, Jason Ernst, Andrei Seluanov, Vera Gorbunova, X William Yang, Ken Raj, Steve Horvath
Using DNA methylation profiles ( n = 15,456) from 348 mammalian species, we constructed phyloepigenetic trees that bear marked similarities to traditional phylogenetic ones. Using unsupervised clustering across all samples, we identified 55 distinct cytosine modules, of which 30 are related to traits such as maximum life span, adult weight, age, sex, and human mortality risk. Maximum life span is associated with methylation levels in HOXL subclass homeobox genes and developmental processes and is potentially regulated by pluripotency transcription factors...
August 11, 2023: Science
#14
REVIEW
Mengmeng Jiang, Jie Ren, Juan Carlos Izpisua Belmonte, Guang-Hui Liu
The liver is one of the few organs that retain the capability to regenerate in adult mammals. This regeneration process is mainly facilitated by the dynamic behavior of hepatocytes, which are the major functional cell type in the liver. In response to liver injury, hepatocytes undergo remarkable alterations, such as reprogramming, wherein they lose their original identity and acquire properties from other cells. This phenomenon of hepatocyte reprogramming, coupled with hepatocyte expansion, plays a central role in liver regeneration, and its underlying mechanisms are complex and multifaceted...
August 9, 2023: FEBS Journal
#15
JOURNAL ARTICLE
Sebastian Memczak, Juan Carlos Izpisua Belmonte
No abstract text is available yet for this article.
August 2023: Nature Cell Biology
#16
JOURNAL ARTICLE
Cui Wang, Kuan Yang, Xiaoqian Liu, Si Wang, Moshi Song, Juan Carlos Izpisua Belmonte, Jing Qu, Guang-Hui Liu, Weiqi Zhang
Mitochondrial dysfunction is a hallmark feature of cellular senescence and organ aging. Here, we asked whether the mitochondrial antiviral signaling protein (MAVS), which is essential for driving antiviral response, also regulates human stem cell senescence. To answer this question, we used CRISPR/Cas9-mediated gene editing and directed differentiation techniques to generate various MAVS-knockout human stem cell models. We found that human mesenchymal stem cells (hMSCs) were sensitive to MAVS deficiency, as manifested by accelerated senescence phenotypes...
2023: Research: a science partner journal
#17
JOURNAL ARTICLE
Marian León, Javier Prieto, María Micaela Molina-Navarro, Francisco García-García, Manuela Barneo-Muñoz, Xavier Ponsoda, Rosana Sáez, Francesc Palau, Joaquín Dopazo, Juan Carlos Izpisua Belmonte, Josema Torres
Charcot-Marie-Tooth disease is a chronic hereditary motor and sensory polyneuropathy targeting Schwann cells and/or motor neurons. Its multifactorial and polygenic origin portrays a complex clinical phenotype of the disease with a wide range of genetic inheritance patterns. The disease-associated gene GDAP1 encodes for a mitochondrial outer membrane protein. Mouse and insect models with mutations in Gdap1 have reproduced several traits of the human disease. However, the precise function in the cell types affected by the disease remains unknown...
July 1, 2023: Cell Death Discovery
#18
JOURNAL ARTICLE
Shanshan Yang, Chengyu Liu, Mengmeng Jiang, Xiaoqian Liu, Lingling Geng, Yiyuan Zhang, Shuhui Sun, Kang Wang, Jian Yin, Shuai Ma, Si Wang, Juan Carlos Izpisua Belmonte, Weiqi Zhang, Jing Qu, Guang-Hui Liu
Aging increases the risk of liver diseases and systemic susceptibility to aging-related diseases. However, cell-type-specific changes and the underlying mechanism of liver aging in higher vertebrates remain incompletely characterized. Here, we constructed the first single-nucleus transcriptomic landscape of primate liver aging, in which we resolved cell-type-specific gene expression fluctuation in hepatocytes across three liver zonations and detected aberrant cell-cell interactions between hepatocytes and niche cells...
June 28, 2023: Protein & Cell
#19
JOURNAL ARTICLE
Qian Zhao, Yandong Zheng, Dongxin Zhao, Liyun Zhao, Lingling Geng, Shuai Ma, Yusheng Cai, Chengyu Liu, Yupeng Yan, Juan Carlos Izpisua Belmonte, Si Wang, Weiqi Zhang, Guang-Hui Liu, Jing Qu
Hair loss affects millions of people at some time in their life, and safe and efficient treatments for hair loss are a significant unmet medical need. We report that topical delivery of quercetin (Que) stimulates resting hair follicles to grow with rapid follicular keratinocyte proliferation and replenishes perifollicular microvasculature in mice. We construct dynamic single-cell transcriptome landscape over the course of hair regrowth and find that Que treatment stimulates the differentiation trajectory in the hair follicles and induces an angiogenic signature in dermal endothelial cells by activating HIF-1α in endothelial cells...
June 7, 2023: Protein & Cell
#20
JOURNAL ARTICLE
Shogo Sato, Tomoaki Hishida, Kenichiro Kinouchi, Fumiaki Hatanaka, Yumei Li, Quy Nguyen, Yumay Chen, Ping H Wang, Kai Kessenbrock, Wei Li, Juan Carlos Izpisua Belmonte, Paolo Sassone-Corsi
Distinct metabolic conditions rewire circadian-clock-controlled signaling pathways leading to the de novo construction of signal transduction networks. However, it remains unclear whether metabolic hallmarks unique to pluripotent stem cells (PSCs) are connected to clock functions. Reprogramming somatic cells to a pluripotent state, here we highlighted non-canonical functions of the circadian repressor CRY1 specific to PSCs. Metabolic reprogramming, including AMPK inactivation and SREBP1 activation, was coupled with the accumulation of CRY1 in PSCs...
May 31, 2023: Cell Reports
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
