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https://www.readbyqxmd.com/read/29451559/linking-chromatin-dynamics-cell-fate-plasticity-and-tissue-homeostasis-in-adult-mouse-hair-follicle-stem-cells
#1
Jayhun Lee, Tudorita Tumbar
Cellular plasticity for fate acquisition is associated with distinct chromatin states, which include histone modifications, dynamic association of chromatin factors with the DNA, and global chromatin compaction and nuclear organization. While embryonic stem cell (ESC) plasticity in vitro and its link with chromatin states have been characterized in depth, little is known about tissue stem cell plasticity in vivo , during adult tissue homeostasis. Recently, we reported a distinct globally low level of histone H3 K4/9/27me3 in mouse hair follicle stem cells (HFSCs) during quiescence...
July 2017: Mol Life
https://www.readbyqxmd.com/read/29451049/the-increase-in-bone-mineral-density-by-bisphosphonate-with-active-vitamin-d-analogue-is-associated-with-the-serum-calcium-level-within-the-reference-interval-in-postmenopausal-osteoporosis
#2
Mayuko Kinoshita, Muneaki Ishijima, Haruka Kaneko, Lizu Liu, Masashi Nagao, Ryo Sadatsuki, Shinnosuke Hada, Hitoshi Arita, Takako Aoki, Makoto Yamanaka, Hidetoshi Nojiri, Yuko Sakamoto, Akifumi Tokita, Kazuo Kaneko
OBJECTIVES: To examine the factors associated with increase in lumbar spine bone mineral density (LS-BMD) by bisphosphonates (BPs) with active vitamin D analogue (aVD). METHODS: Two independent postmenopausal osteoporotic patients treated by BPs with aVD for 24 months (Study1:n = 93,Study2:n = 99) were retrospectively analyzed. RESULTS: In Study1, LS-BMD of the patients significantly increased for 24m (5.4%,p<0.001). A multiple regression analysis among baseline characteristics revealed that serum calcium (sCa:8...
February 16, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/29446654/hypouricaemic-effects-of-yogurt-containing-lactobacillus-gasseri-pa-3-in-patients-with-hyperuricaemia-and-or-gout-a-randomized-double-blind-placebo-controlled-study
#3
Hisashi Yamanaka, Atsuo Taniguchi, Hiroshi Tsuboi, Hiroshi Kano, Yukio Asami
PURPOSE: Lactobacillus gasseri PA-3 (PA-3) has been previously shown to decrease serum uric acid (SUA) levels in subjects with increased SUA. In this study, we investigated whether PA-3 is also capable of decreasing SUA levels in patients with hyperuricaemia and/or gout. METHODS: Twenty-five patients with hyperuricaemia and/or gout completed this study. Urate-lowering drugs were discontinued for 12 weeks (week -4 to week 8). After flushing of urate-lowering drugs for 4 weeks (week 0), patients were randomized equally to receive diets containing yogurt beverages with PA-3 or without PA-3 for a duration of 8 weeks (week 8)...
February 15, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/29445206/nanostructuring-one-dimensional-and-amorphous-lithium-peroxide-for-high-round-trip-efficiency-in-lithium-oxygen-batteries
#4
Arghya Dutta, Raymond A Wong, Woonghyeon Park, Keisuke Yamanaka, Toshiaki Ohta, Yousung Jung, Hye Ryung Byon
The major challenge facing lithium-oxygen batteries is the insulating and bulk lithium peroxide discharge product, which causes sluggish decomposition and increasing overpotential during recharge. Here, we demonstrate an improved round-trip efficiency of ~80% by means of a mesoporous carbon electrode, which directs the growth of one-dimensional and amorphous lithium peroxide. Morphologically, the one-dimensional nanostructures with small volume and high surface show improved charge transport and promote delithiation (lithium ion dissolution) during recharge and thus plays a critical role in the facile decomposition of lithium peroxide...
February 14, 2018: Nature Communications
https://www.readbyqxmd.com/read/29445086/the-oncogene-etv5-promotes-met-in-somatic-reprogramming-and-orchestrates-epiblast-primitive-endoderm-specification-during-mescs-differentiation
#5
Jinglong Zhang, Hongxia Cao, Jing Xie, Chen Fan, Youlong Xie, Xin He, Mingzhi Liao, Shiqiang Zhang, Huayan Wang
Unipotent spermatogonial stem cells (SSCs) can be efficiently reprogrammed into pluripotent stem cells only by manipulating the culture condition, without introducing exogenous reprogramming factors. This phenotype raises the hypothesis that the endogenous transcription factors (TFs) in SSCs may facilitate reprogramming to acquire pluripotency. In this study, we screened a pool of SSCs TFs (Bcl6b, Lhx1, Foxo1, Plzf, Id4, Taf4b, and Etv5), and found that oncogene Etv5 could dramatically increase the efficiency of induced pluripotent stem cells (iPSCs) generation when combined with Yamanaka factors...
February 14, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29443652/placebo-controlled-double-blinded-phase-iii-study-comparing-dexamethasone-on-day-1-with-dexamethasone-on-days-1-to-3-with-combined-neurokinin-1-receptor-antagonist-and-palonosetron-in-high-emetogenic-chemotherapy
#6
Yuka Ito, Takashi Tsuda, Hiroko Minatogawa, Sayaka Kano, Kentaro Sakamaki, Masahiko Ando, Koichiro Tsugawa, Yasuyuki Kojima, Naoki Furuya, Kunihiro Matsuzaki, Mamoru Fukuda, Sadatoshi Sugae, Ichiro Ohta, Hitoshi Arioka, Yutaka Tokuda, Kazutaka Narui, Ayako Tsuboya, Takashi Suda, Satoshi Morita, Narikazu Boku, Takeharu Yamanaka, Takako Eguchi Nakajima
Purpose We evaluated the noninferiority of dexamethasone (DEX) on day 1, with sparing on days 2 and 3, combined with neurokinin-1 receptor antagonist (NK1-RA) and palonosetron (Palo) compared with the 3-day use of DEX in highly-emetogenic chemotherapy (HEC). Patients and Methods Patients who were scheduled to receive HEC (cisplatin ≥ 50 mg/m2or anthracycline plus cyclophosphamide) were randomly assigned to receive either DEX on days 1 to 3 (Arm D3) or DEX on day 1 and placebo on days 2 and 3 (Arm D1) combined with NK1-RA and Palo...
February 14, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29438301/ultrasensitive-determination-of-malathion-using-acetylcholinesterase-immobilized-on-chitosan-functionalized-magnetic-iron-nanoparticles
#7
Núbia Fernanda Marinho Rodrigues, Sakae Yotsumoto Neto, Rita de Cássia Silva Luz, Flávio Santos Damos, Hideko Yamanaka
A renewable, disposable, low cost, and sensitive sensor for the detection of organophosphorus pesticides was constructed by immobilizing the acetylcholinesterase enzyme (AChE), via glutaraldehyde, on magnetic iron nanoparticles (Fe₃O₄) previously synthesized and functionalized with chitosan (CS). The sensor was denoted AChE/CS/Fe₃O₄. The magnetic nanoparticles were characterized by Fourier transform infrared spectroscopy and transmission electron microscopy. Acetylthiocholine (ATCh) was incubated with AChE/CS/Fe₃O₄ and attached to a screen-printed electrode using a magnet...
February 13, 2018: Biosensors
https://www.readbyqxmd.com/read/29432471/in-vitro-mouse-spermatogenesis-with-an-organ-culture-method-in-chemically-defined-medium
#8
Hiroyuki Sanjo, Mitsuru Komeya, Takuya Sato, Takeru Abe, Kumiko Katagiri, Hiroyuki Yamanaka, Yoko Ino, Noriaki Arakawa, Hisashi Hirano, Tatsuma Yao, Yuta Asayama, Akio Matsuhisa, Masahiro Yao, Takehiko Ogawa
We previously reported the successful induction and completion of mouse spermatogenesis by culturing neonatal testis tissues. The culture medium consisted of α-minimum essential medium (α-MEM), supplemented with Knockout serum replacement (KSR) or AlbuMAX, neither of which were defined chemically. In this study, we formulated a chemically defined medium (CDM) that can induce mouse spermatogenesis under organ culture conditions. It was found that bovine serum albumin (BSA) purified through three different procedures had different effects on spermatogenesis...
2018: PloS One
https://www.readbyqxmd.com/read/29432147/global-rise-in-emerging-alien-species-results-from-increased-accessibility-of-new-source-pools
#9
Hanno Seebens, Tim M Blackburn, Ellie E Dyer, Piero Genovesi, Philip E Hulme, Jonathan M Jeschke, Shyama Pagad, Petr Pyšek, Mark van Kleunen, Marten Winter, Michael Ansong, Margarita Arianoutsou, Sven Bacher, Bernd Blasius, Eckehard G Brockerhoff, Giuseppe Brundu, César Capinha, Charlotte E Causton, Laura Celesti-Grapow, Wayne Dawson, Stefan Dullinger, Evan P Economo, Nicol Fuentes, Benoit Guénard, Heinke Jäger, John Kartesz, Marc Kenis, Ingolf Kühn, Bernd Lenzner, Andrew M Liebhold, Alexander Mosena, Dietmar Moser, Wolfgang Nentwig, Misako Nishino, David Pearman, Jan Pergl, Wolfgang Rabitsch, Julissa Rojas-Sandoval, Alain Roques, Stephanie Rorke, Silvia Rossinelli, Helen E Roy, Riccardo Scalera, Stefan Schindler, Kateřina Štajerová, Barbara Tokarska-Guzik, Kevin Walker, Darren F Ward, Takehiko Yamanaka, Franz Essl
Our ability to predict the identity of future invasive alien species is largely based upon knowledge of prior invasion history. Emerging alien species-those never encountered as aliens before-therefore pose a significant challenge to biosecurity interventions worldwide. Understanding their temporal trends, origins, and the drivers of their spread is pivotal to improving prevention and risk assessment tools. Here, we use a database of 45,984 first records of 16,019 established alien species to investigate the temporal dynamics of occurrences of emerging alien species worldwide...
February 5, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29426934/involvement-of-orexin-neurons-in-fasting-and-central-adenosine-induced-hypothermia
#10
Takahiro Futatsuki, Akira Yamashita, Khairunnisa Novita Ikbar, Akihiro Yamanaka, Kazunori Arita, Yasuyuki Kakihana, Tomoyuki Kuwaki
We examined whether orexin neurons might play a protective role against fasting- and adenosine-induced hypothermia. We first measured body temperature (BT) in orexin neuron-ablated (ORX-AB) mice and wild-type (WT) controls during 24 hours of fasting. As expected, the magnitude of BT drop and the length of time suffering from hypothermia were greater in ORX-AB mice than in WT mice. Orexin neurons were active just before onset of hypothermia and during the recovery period as revealed by calcium imaging in vivo using G-CaMP...
February 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29424424/adult-specific-insulin-producing-neurons-in-drosophila-melanogaster
#11
Yuya Ohhara, Satoru Kobayashi, Kimiko Yamakawa-Kobayashi, Naoki Yamanaka
Holometabolous insects undergo metamorphosis to reorganize their behavioral and morphological features into adult-specific ones. In the central nervous system (CNS), some larval neurons undergo programmed cell death, whereas others go through remodeling of axonal and dendritic arbors to support functions of re-established adult organs. Although there are multiple neuropeptides that have stage-specific roles in holometabolous insects, the reorganization pattern of the entire neuropeptidergic system through metamorphosis still remains largely unclear...
February 9, 2018: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/29422649/dielectric-jump-and-negative-electrostriction-in-metallosupramolecular-ionic-crystals
#12
Satoshi Yamashita, Yasuhiro Nakazawa, Shusuke Yamanaka, Mitsutaka Okumura, Tatsuhiro Kojima, Nobuto Yoshinari, Takumi Konno
In natural ionic solids, cationic and anionic species are alternately arranged to minimize electrostatic energy. Aggregation of identical ionic species is commonly prohibited due to the repulsive, long-range nature of Coulombic interactions. Recently, we synthesized unique ionic solids, [AuI4CoIII2(dppe)2(D-pen)4]X2·nH2O (dppe = 1,2-bis(diphenylphosphino)ethane, D-pen = D-penicillaminate), in which complex cations are self-assembled into a cationic supramolecular octahedron, while monovalent or divalent inorganic anions are aggregated into an anomalous anionic cluster accommodating several water molecules...
February 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29421061/physicochemical-and-immunological-characterization-of-chitosan-coated-bacteriophage-nanoparticles-for-in-vivo-mycotoxin-modeling
#13
Carla Yoko Tanikawa de Andrade, Isabel Yamanaka, Laís S Schlichta, Sabrina Karim Silva, Guilherme F Picheth, Luiz Felipe Caron, Juliana de Moura, Rilton Alves de Freitas, Larissa Magalhães Alvarenga
To propose a novel modeling of aflatoxin immunization and surrogate toxin conjugate from AFB1 vaccines, an immunogen based on the mimotope, (i.e. a peptide-displayed phage that mimics aflatoxins epitope without toxin hazards) was designed. The recombinant phage 3P30 was identified by phage display technology and exhibited the ability to bind, dose dependent, specifically to its cognate target - anti-AFB1 antibody. In immunization assay, the phage-displayed mimotope and its peptide chemically synthesized were able to induce specific anti-AFB1 antibodies, indicating the proof of concept for aflatoxin mimicry...
April 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29419463/hla-drb1-analysis-identified-a-genetically-unique-subset-within-rheumatoid-arthritis-and-distinct-genetic-background-of-rheumatoid-factor-levels-from-anticyclic-citrullinated-peptide-antibodies
#14
Ryosuke Hiwa, Katsunori Ikari, Koichiro Ohmura, Shuichiro Nakabo, Keitaro Matsuo, Hiroh Saji, Kimiko Yurugi, Yasuo Miura, Taira Maekawa, Atsuo Taniguchi, Hisashi Yamanaka, Fumihiko Matsuda, Tsuneyo Mimori, Chikashi Terao
OBJECTIVE: HLA-DRB1 is the most important locus associated with rheumatoid arthritis (RA) and anticitrullinated protein antibodies (ACPA). However, fluctuations of rheumatoid factor (RF) over the disease course have made it difficult to define fine subgroups according to consistent RF positivity for the analyses of genetic background and the levels of RF. METHODS: A total of 2873 patients with RA and 2008 healthy controls were recruited. We genotyped HLA-DRB1 alleles for the participants and collected consecutive data of RF in the case subjects...
February 1, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29414604/derivation-of-human-induced-pluripotent-stem-cell-line-husti001-a-from-a-40-year-old-patient-with-idiopathic-infertility
#15
Fang Fang, Zili Li, Qian Zhao, Zhen Ye, Kai Zhao, Xiuli Gu, Shiliang Shen, Renee A Reijo Pera, Chengliang Xiong
Human fibroblasts were isolated from foreskin of a clinically diagnosed 40-year old patient with idiopathic infertility. The fibroblasts were reprogrammed with the Yamanaka KOSM transcriptional factors using the retroviral vectors. The obtained induced pluripotent stem cell (iPSC) line showed pluripotency verified by the expression of pluripotency markers, NANOG, SOX2, OCT4, TRA-1-60, and SSEA-4. And the iPSC line was demonstrated to have the three germ layers differentiation capacity in vivo by teratoma assay...
January 27, 2018: Stem Cell Research
https://www.readbyqxmd.com/read/29409869/the-role-of-hippocampal-brain-derived-neurotrophic-factor-in-age-related-differences-in-neuropathic-pain-behavior-in-rats
#16
Hiroki Tateiwa, Takashi Kawano, Atsushi Nishigaki, Daiki Yamanaka, Bun Aoyama, Marie Shigematsu-Locatelli, Satoru Eguchi, Fabricio M Locatelli, Masataka Yokoyama
AIMS: This study was aimed to explore the contribution of central brain-derived neurotrophic factor (BDNF) in the neuropathic pain pathogenesis using an aged rodent model. MAIN METHODS: Adult and aged rats were randomly assigned to either a sciatic nerve ligation (SNL) group or a control skin sham surgery group. Sensory behavioral testing were performed on the day before surgery and on the 3rd, 7th, 14th, and 21st days after surgery, followed by measurement of BDNF protein levels in different brain regions...
January 31, 2018: Life Sciences
https://www.readbyqxmd.com/read/29408977/phase-ii-trial-of-combination-treatment-with-paclitaxel-carboplatin-and-cetuximab-pce-as-first-line-treatment-in-patients-with-recurrent-and-or-metastatic-squamous-cell-carcinoma-of-the-head-and-neck-cspor-hn02
#17
M Tahara, N Kiyota, T Yokota, Y Hasegawa, K Muro, S Takahashi, T Onoe, A Homma, J Taguchi, M Suzuki, K Minato, K Yane, S Ueda, H Hara, K Saijo, T Yamanaka
Background: The standard of care for first-line treatment of recurrent and/or metastatic squamous cell carcinoma of the head and neck (R/M SCCHN) is combination treatment with platinum, 5-FU and cetuximab (PFE). However, this regimen requires hospitalization to ensure proper hydration and continuous infusion of 5-FU, and causes severe nausea and anorexia. We evaluated the efficacy and safety of paclitaxel, carboplatin and cetuximab (PCE) as first-line treatment in patients with R/M SCCHN...
February 2, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29408475/optimal-route-of-diphtheria-toxin-administration-to-eliminate-native-nephron-progenitor-cells-in-vivo-for-kidney-regeneration
#18
Shohei Fukunaga, Shuichiro Yamanaka, Toshinari Fujimoto, Susumu Tajiri, Taketo Uchiyama, Kei Matsumoto, Takafumi Ito, Kazuaki Tanabe, Takashi Yokoo
To address the lack of organs for transplantation, we previously developed a method for organ regeneration in which nephron progenitor cell (NPC) replacement is performed via the diphtheria toxin receptor (DTR) system. In transgenic mice with NPC-specific expression of DTR, NPCs were eliminated by DT and replaced with NPCs lacking the DTR with the ability to differentiate into nephrons. However, this method has only been verified in vitro. For applications to natural models, such as animal fetuses, it is necessary to determine the optimal administration route and dose of DT...
January 30, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29404853/implantation-of-multiple-polytetrafluoroethylene-covered-stent-inside-drug-eluting-stent-to-rescue-purulent-coronary-artery-ectasia-with-giant-saccular-aneurysm
#19
Yusuke Namba, Toshiaki Yamanaka, Jun Ida, Takefumi Oka
A 79-year-old male with diabetes mellitus and old cerebral infarction was admitted to hospital due to fever and palpitation. Diagnosis of purulent pericarditis was established by pericardial effusion examination. The patient's general condition improved temporarily after drainage of the pericardial effusion. However, computed tomography demonstrated a saccular aneurysm arising from RCA have rapidly grown even larger, up to 63 × 51 mm on 7th hospital day. This indicated that the risk of rupture of the aneurysm was high...
February 5, 2018: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/29404229/clinical-implications-of-a-novel-iron-containing-fiducial-marker-in-radiotherapy-for-liver-tumors-an-initial-experience
#20
Hiroshi Doi, Shogo Harui, Hiroki Nakajima, Akira Ando, Keiji Kamino, Masayuki Fujiwara, Takayoshi Nakajima, Shinichi Ikura, Tsukasa Aihara, Naoki Yamanaka
A 0.5%-iron-containing fiducial marker, Gold AnchorTM (Naslund Medical AB, Huddinge, Sweden), has been recently developed. Herein, we report our initial experiences with the clinical use of the Gold AnchorTM (GA) in radiotherapy for liver tumors. Data of four consecutive patients with liver tumors, including two liver metastases and two hepatocellular carcinomas, were retrospectively analyzed. The GA was percutaneously placed under local anesthesia, close to the tumor. Gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid-enhanced magnetic resonance imaging (MRI) was performed after the placement of the GA...
December 1, 2017: Curēus
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