keyword
https://read.qxmd.com/read/38535481/cell-reprogramming-and-differentiation-utilizing-messenger-rna-for-regenerative-medicine
#1
REVIEW
Masahito Inagaki
The COVID-19 pandemic generated interest in the medicinal applications of messenger RNA (mRNA). It is expected that mRNA will be applied, not only to vaccines, but also to regenerative medicine. The purity of mRNA is important for its medicinal applications. However, the current mRNA synthesis techniques exhibit problems, including the contamination of undesired 5'-uncapped mRNA and double-stranded RNA. Recently, our group developed a completely capped mRNA synthesis technology that contributes to the progress of mRNA research...
December 20, 2023: Journal of Developmental Biology
https://read.qxmd.com/read/38532563/the-role-of-mast-cells-and-related-molecules-in-itch-of-hidradenitis-suppurativa
#2
JOURNAL ARTICLE
Mika Yamanaka-Takaichi, Addison M Demer, Christian L Baum, Theoharis C Theoharides, Afsaneh Alavi
No abstract text is available yet for this article.
March 2024: Experimental Dermatology
https://read.qxmd.com/read/38531347/proportion-and-correlates-of-children-in-the-us-affiliated-pacific-region-meeting-sleep-screen-time-and-physical-activity-guidelines
#3
JOURNAL ARTICLE
Sarah T Ryan, Anthony D Okely, Kar Hau Chong, Rebecca M Stanley, Melanie Randle, Gade Waqa, Ashley B Yamanaka, Rachael Leon Guerrero, Patricia Coleman, Leslie Shallcross, Lynne R Wilkens, Jonathan L Deenik, Rachel Novotny
INTRODUCTION: Limited data on 24-hour movement behaviors of children aged 5-8 years exist globally. We describe the prevalence and sociodemographic associations of meeting physical activity (PA), sedentary recreational screen time (ST), and sleep guidelines among children from 11 jurisdictions in the US-Affiliated Pacific region. METHODS: Cross-sectional representative data from 1192 children aged 5-8 years living in the US-Affiliated Pacific region were drawn from the baseline 2012-2014 Children's Healthy Living Program...
March 26, 2024: Journal of Physical Activity & Health
https://read.qxmd.com/read/38528945/successful-thoracoscopic-operative-approach-for-refractory-pneumothorax-in-interstitial-lung-disease-under-local-anaesthesia
#4
Shinya Yamanaka, Clara So, Naoki Nishimura, Tomoaki Nakamura, Shinsaku Kabemura, Ryosuke Kumagai, Kohei Okafuji, Atsushi Kitamura, Fumitsugu Kojima, Yutaka Tomishima, Torahiko Jinta, Toru Bando
Refractory pneumothorax associated with interstitial lung disease (ILD) remains a challenging condition due to the patient's tolerability and lung compliance that restrict the feasibility of aggressive interventions. Additionally, many cases recur after improvement with treatment, and reports of successful management for this complicated condition are limited. Herein, we report the case of a 60-year-old man with ILD, utilizing home oxygen therapy, who experienced a successful recovery from a surgical intervention under local anaesthesia for pneumothorax...
March 2024: Respirology Case Reports
https://read.qxmd.com/read/38526741/working-memory-load-modulates-anticipatory-postural-adjustments-during-step-initiation
#5
JOURNAL ARTICLE
Kodai Minami, Eiji Yamanaka, Kohei Okuyama, Michiyuki Kawakami, Kunitsugu Kondo, Riku Ishizaka, Aoki Takahashi, Tatsunori Watanabe
Working memory (WM) can influence selective attention. However, the effect of WM load on postural standing tasks has been poorly understood, even though these tasks require attentional resources. The purpose of this study was to examine whether WM load would impact anticipatory postural adjustments (APAs) during step initiation. Sixteen healthy young adults performed stepping tasks alone or concurrently with a WM task in a dual-task design. The stepping tasks involved volitional stepping movements in response to visual stimuli and comprised of simple and choice reaction time tasks and the Flanker task which consisted of congruent and incongruent (INC) conditions...
March 25, 2024: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://read.qxmd.com/read/38520160/the-role-of-orexin-in-parkinson-s-disease
#6
REVIEW
Alisha Braun, Jim Manavis, Akihiro Yamanaka, Youichirou Ootsuka, Peter Blumbergs, Larisa Bobrovskaya
Emerging evidence has implicated the orexin system in non-motor pathogenesis of Parkinson's disease. It has also been suggested the orexin system is involved in the modulation of motor control, further implicating the orexin system in Parkinson's disease. Parkinson's disease is the second most common neurodegenerative disease with millions of people suffering worldwide with motor and non-motor symptoms, significantly affecting their quality of life. Treatments are based solely on symptomatic management and no cure currently exists...
March 2024: Journal of Neuroscience Research
https://read.qxmd.com/read/38517750/multi-omics-characterization-of-partial-chemical-reprogramming-reveals-evidence-of-cell-rejuvenation
#7
JOURNAL ARTICLE
Wayne Mitchell, Ludger J E Goeminne, Alexander Tyshkovskiy, Sirui Zhang, Julie Y Chen, Joao A Paulo, Kerry A Pierce, Angelina H Choy, Clary B Clish, Steven P Gygi, Vadim N Gladyshev
Partial reprogramming by cyclic short-term expression of Yamanaka factors holds promise for shifting cells to younger states and consequently delaying the onset of many diseases of aging. However, the delivery of transgenes and potential risk of teratoma formation present challenges for in vivo applications. Recent advances include the use of cocktails of compounds to reprogram somatic cells, but the characteristics and mechanisms of partial cellular reprogramming by chemicals remain unclear. Here, we report a multi-omics characterization of partial chemical reprogramming in fibroblasts from young and aged mice...
March 22, 2024: ELife
https://read.qxmd.com/read/38512717/alkyl-%C3%AF-functional-molecular-gels-control-of-elastic-modulus-and-improvement-of-electret-performance
#8
JOURNAL ARTICLE
Akito Tateyama, Kazuhiko Nagura, Masamichi Yamanaka, Takashi Nakanishi
The development of optoelectronically-active soft materials is drawing attention to the application of soft electronics. A room-temperature solvent-free liquid obtained by modifying a π-conjugated moiety with flexible yet bulky alkyl chains is a promising functional soft material. Tuning the elastic modulus (G') is essential for employing optoelectronically-active alkyl-π liquids in deformable devices. However, the range of G' achieved through the molecular design of alkyl-π liquids is limited...
March 21, 2024: Angewandte Chemie
https://read.qxmd.com/read/38511674/engineering-a-monobody-specific-to-monomeric-cu-zn-superoxide-dismutase-associated-with-amyotrophic-lateral-sclerosis
#9
JOURNAL ARTICLE
Hiroshi Amesaka, Mizuho Hara, Yuki Sakai, Atsuko Shintani, Kaori Sue, Tomoyuki Yamanaka, Shun-Ichi Tanaka, Yoshiaki Furukawa
Misfolding of mutant Cu/Zn-superoxide dismutase (SOD1) has been implicated in familial form of amyotrophic lateral sclerosis (ALS). A natively folded SOD1 forms a tight homodimer, and the dimer dissociation has been proposed to trigger the oligomerization/aggregation of SOD1. Besides increasing demand for probes allowing the detection of monomerized forms of SOD1 in various applications, the development of probes has been limited to conventional antibodies. Here, we have developed Mb(S4) monobody, a small synthetic binding protein based on the fibronectin type III scaffold, that recognizes a monomeric but not dimeric form of SOD1 by performing combinatorial library selections using phage and yeast-surface display methods...
April 2024: Protein Science
https://read.qxmd.com/read/38509731/induced-pluripotent-stem-cell-based-assays-recapture-multiple-properties-of-human-astrocytes
#10
JOURNAL ARTICLE
Hideki Nonaka, Takayuki Kondo, Mika Suga, Ryu Yamanaka, Yukako Sagara, Kayoko Tsukita, Naoko Mitsutomi, Kengo Homma, Ryuta Saito, Fumihiko Miyoshi, Hiromitsu Ohzeki, Masahiro Okuyama, Haruhisa Inoue
The majority of the population of glial cells in the central nervous system consists of astrocytes, and impairment of astrocytes causes various disorders. It is useful to assess the multiple astrocytic properties in order to understand their complex roles in the pathophysiology. Although we can differentiate human astrocytes from induced pluripotent stem cells (iPSCs), it remains unknown how we can analyse and reveal the multiple properties of astrocytes in complexed human disease conditions. For this purpose, we tested astrocytic differentiation protocols from feeder-free iPSCs based on the previous method with some modifications...
April 2024: Journal of Cellular and Molecular Medicine
https://read.qxmd.com/read/38505039/what-are-the-risk-factors-for-postoperative-home-oxygen-therapy-in-patients-with-lung-cancer
#11
JOURNAL ARTICLE
Takahiro Yamanaka, Yuichi Sakairi, Yuki Sata, Takahide Toyoda, Terunaga Inage, Kazuhisa Tanaka, Hidemi Suzuki, Yukiko Matsui, Ichiro Yoshino
BACKGROUND: Home oxygen therapy (HOT) is used to treat chronic respiratory diseases and is sometimes required in patients with lung cancer after radical surgery. We aimed to identify the risk factors for postoperative home-based oxygen therapy in patients with lung cancer. METHODS: Patients who underwent surgery for primary lung cancer at Chiba University Hospital between January 2019 and March 2021 were included. Patients who did not undergo complete resection, died in hospital after surgery, or used oxygen therapy preoperatively were excluded...
February 29, 2024: Journal of Thoracic Disease
https://read.qxmd.com/read/38503637/side-branch-embolization-before-endovascular-abdominal-aortic-aneurysm-repair-to-prevent-type-ii-endoleak-a-prospective-multicenter-study
#12
JOURNAL ARTICLE
Tomoyuki Gentsu, Masato Yamaguchi, Koji Sasaki, Ryota Kawasaki, Hiroki Horinouchi, Tetsuya Fukuda, Naokazu Miyamoto, Takeki Mori, Noriaki Sakamoto, Kensuke Uotani, Takanori Taniguchi, Yojiro Koda, Katsuhiro Yamanaka, Hiroaki Takahashi, Kenji Okada, Taro Hayashi, Toshitaka Watanabe, Yoshikatsu Nomura, Keigo Matsushiro, Eisuke Ueshima, Takuya Okada, Koji Sugimoto, Takamichi Murakami
PURPOSE: The purpose of the study was to evaluate the efficacy and safety of pre-emptive transcatheter arterial embolization (P-TAE) of aortic side branches to prevent type II endoleak in patients with abdominal aortic aneurysm after endovascular abdominal aneurysm repair (EVAR). MATERIALS AND METHODS: This multicenter, prospective, single-arm trial enrolled 100 patients with abdominal aortic aneurysm from nine hospitals between 2018 and 2021. There were 85 men and 15 women, with a mean age of 79...
March 18, 2024: Diagnostic and Interventional Imaging
https://read.qxmd.com/read/38502704/morc1-reestablishes-h3k9me3-heterochromatin-on-pirna-targeted-transposons-in-gonocytes
#13
JOURNAL ARTICLE
Yuta Uneme, Ryu Maeda, Gen Nakayama, Haruka Narita, Naoki Takeda, Ryuji Hiramatsu, Hidenori Nishihara, Ryuichiro Nakato, Yoshiakira Kanai, Kimi Araki, Mikiko C Siomi, Soichiro Yamanaka
To maintain fertility, male mice re-repress transposable elements (TEs) that were de-silenced in the early gonocytes before their differentiation into spermatogonia. However, the mechanism of TE silencing re-establishment remains unknown. Here, we found that the DNA-binding protein Morc1, in cooperation with the methyltransferase SetDB1, deposits the repressive histone mark H3K9me3 on a large fraction of activated TEs, leading to heterochromatin. Morc1 also triggers DNA methylation, but TEs targeted by Morc1-driven DNA methylation only slightly overlapped with those repressed by Morc1/SetDB1-dependent heterochromatin formation, suggesting that Morc1 silences TEs in two different manners...
March 26, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38502294/skeletal-muscle-derived-irisin-enhances-gemcitabine-sensitivity-and-suppresses-migration-ability-in-pancreatic-ductal-adenocarcinoma
#14
JOURNAL ARTICLE
Tomoki Sugimoto, Yoshifumi Iwagami, Shogo Kobayashi, Chihiro Yamanaka, Kazuki Sasaki, Daisaku Yamada, Yoshito Tomimaru, Tadafumi Asaoka, Takehiro Noda, Hidenori Takahashi, Junzo Shimizu, Yuichiro Doki, Hidetoshi Eguchi
BACKGROUND: High skeletal muscle mass might be a prognostic factor for patients with pancreatic ductal adenocarcinoma (PDAC); however, the underlying reason is unclear. We hypothesized that myokines, which are cytokines secreted by the skeletal muscle, function as suppressors of PDAC. We specifically examined irisin, a myokine, which plays a critical role in the modulation of metabolism, to clarify the anticancer mechanisms. METHODS: First, the effect of the conditioned medium (CM) from skeletal muscle cells and from irisin-knockdown skeletal muscle cells on PDAC cell lines was evaluated...
March 19, 2024: Annals of Surgical Oncology
https://read.qxmd.com/read/38491297/comparative-evaluation-for-the-performance-of-environmental-dna-and-rna-analyses-targeting-mitochondrial-and-nuclear-genes-from-ayu-plecoglossus-altivelis
#15
JOURNAL ARTICLE
Toshiaki S Jo, Nao Matsuda, Takaya Hirohara, Hiroki Yamanaka
Environmental DNA and RNA (eDNA and eRNA; collectively eNA) analyses have the potential for non-invasive and cost-efficient biomonitoring compared with traditional capture-based surveys. Although various types of eNA particles, including not only mitochondrial eDNA but also nuclear eDNA and their transcripts, are present in the water, performances of eNA detection and quantification have not yet been evaluated sufficiently across multiple mitochondrial and nuclear genes. We conducted a tank experiment with ayu (Plecoglossus altivelis) to compare the detection sensitivity, yields per water sample, and quantification variability between replicates of each type of eNAs...
March 16, 2024: Environmental Monitoring and Assessment
https://read.qxmd.com/read/38483432/differentiating-generalized-pustular-psoriasis-from-acute-generalized-exanthematous-pustulosis
#16
JOURNAL ARTICLE
Mika Yamanaka-Takaichi, Miki Watanabe, Nneka I Comfere, Olayemi Sokumbi, Christeebella O Akpala, Austin Todd, Emily L Branch, Aaron R Mangold, Sho Hiroyasu, Daisuke Tsuruta, Afsaneh Alavi
No abstract text is available yet for this article.
March 13, 2024: Journal of the American Academy of Dermatology
https://read.qxmd.com/read/38479451/preemptive-aortic-side-branch-embolization-during-evar-using-the-excluder-stent-graft-system-a-prospective-multicenter-study
#17
JOURNAL ARTICLE
Koji Sasaki, Masato Yamaguchi, Tomoyuki Gentsu, Ryota Kawasaki, Naokazu Miyamoto, Kensuke Uotani, Noriaki Sakamoto, Tetsuya Fukuda, Hiroki Horinouchi, Takanori Taniguchi, Takeki Mori, Yojiro Koda, Katsuhiro Yamanaka, Hiroaki Takahashi, Kenji Okada, Toshitaka Watanabe, Taro Hayashi, Yoshikatsu Nomura, Keigo Matsushiro, Eisuke Ueshima, Takuya Okada, Koji Sugimoto, Takamichi Murakami
PURPOSE: The occurrence of endoleaks, particularly type 2 endoleaks (EL2), is the primary cause of poor long-term prognosis after endovascular aneurysm repair (EVAR). This study aimed to evaluate the efficacy and safety of preemptive transcatheter arterial embolization (P-TAE) for aortic side branches (ASBs) to prevent EL2 before EVAR using the Excluder stent-graft system (EXCLUDER). MATERIALS AND METHODS: In this prospective, multicenter study, 80 patients (mean age, 79...
March 11, 2024: Journal of Vascular and Interventional Radiology: JVIR
https://read.qxmd.com/read/38471963/prevalence-of-high-and-low-serum-alkaline-phosphatase-levels-and-the-associated-factors-in-patients-with-rheumatoid-arthritis-results-from-the-iorra-cohort-study
#18
JOURNAL ARTICLE
Takefumi Furuya, Eisuke Inoue, Eiichi Tanaka, Hisashi Yamanaka, Masayoshi Harigai
No abstract text is available yet for this article.
March 13, 2024: Modern Rheumatology
https://read.qxmd.com/read/38459840/-the-long-outcome-of-the-left-atrial-appendage-preserving-maze-procedure
#19
JOURNAL ARTICLE
Kazuo Yamanaka, Takeshi Nishina, Yuji Sekine, Daisuke Nakatsuka, Shun Sato, Yuichi Tara, Yuri Hashimura, Yuichi Ueda
UNLABELLED: We retrospectively study the outcome of left atrial appendage (LAA) preserving maze procedure, focus on thrombus formation in left atrium( LA), postoperative stroke, and LA function. PATIENTS AND METHODS: We studied 131 patients (mean age, 68.2y;77 men and 54 women) who underwent maze procedure for atrial fibrillation( Af) between 2008 and 2020. Full maze was performed for 116 patients with long-standing persistent Af or persistent Af. Pulmonary vein isolation alone was performed for 15 patients with paroxysmal Af...
January 2024: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://read.qxmd.com/read/38456881/late-sinus-sequestration-after-tavr-in-tavr-rescued-by-coronary%C3%A2-artery-bypass-grafting
#20
JOURNAL ARTICLE
Tomoki Ochiai, Futoshi Yamanaka, Tsuyoshi Yamabe, Hirokazu Miyashita, Noriaki Moriyama, Koki Shishido, Kiyotaka Iwasaki, Shigeru Saito
No abstract text is available yet for this article.
February 17, 2024: JACC. Cardiovascular Interventions
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