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https://www.readbyqxmd.com/read/28817566/inhibition-of-mutagenic-translesion-synthesis-a-possible-strategy-for-improving-chemotherapy
#1
Kinrin Yamanaka, Nimrat Chatterjee, Michael T Hemann, Graham C Walker
No abstract text is available yet for this article.
August 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28816158/a-multi-institutional-prospective-observational-study-of-stereotactic-radiosurgery-for-patients-with-multiple-brain-metastases-jlgk0901-study-update-irradiation-related-complications-and-long-term-maintenance-of-mini-mental-state-examination-scores
#2
Masaaki Yamamoto, Toru Serizawa, Yoshinori Higuchi, Yasunori Sato, Jun Kawagishi, Kazuhiro Yamanaka, Takashi Shuto, Atsuya Akabane, Hidefumi Jokura, Shoji Yomo, Osamu Nagano, Hidefumi Aoyama
PURPOSE: The JLGK0901 study showed the noninferiority of stereotactic radiosurgery (SRS) alone as initial treatment of 5 to 10 brain metastases (BMs) compared with 2 to 4 BMs in terms of overall survival and most secondary endpoints (Lancet Oncol 2014;15:387-95). However, observation periods were not long enough to allow confirmation of the long-term safety of SRS alone in patients with 5 to 10 BMs. METHODS AND MATERIALS: This was a prospective observational study of Gamma Knife SRS-treated patients with 1 to 10 newly diagnosed BMs enrolled at 23 facilities between March 1, 2009, and February 15, 2012...
September 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28815312/trilateral-retinoblastoma-a-systematic-review-of-211-cases
#3
REVIEW
Ryuya Yamanaka, Azusa Hayano, Yasuo Takashima
We conducted a systematic review of 72 studies to characterize trilateral retinoblastomas. Kaplan-Meier analysis was used to estimate survival, and statistical significance was assessed by using a log-rank test. We analyzed 211 cases of trilateral retinoblastomas. The average age of onset of retinoblastoma was 0.79 ± 1.38 years, and the average latency period between the onset of retinoblastomas and trilateral retinoblastomas was 1.49 ± 1.76 years. The brain tumors were found before the retinoblastoma diagnosis in 6 cases (3...
August 16, 2017: Neurosurgical Review
https://www.readbyqxmd.com/read/28815178/stem-cell-manipulation-gene-therapy-and-the-risk-of-cancer-stem-cell-emergence
#4
REVIEW
Flora Clément, Elodie Grockowiak, Florence Zylbersztejn, Gaëlle Fossard, Stéphanie Gobert, Véronique Maguer-Satta
Stem cells (SCs) have been extensively studied in the context of regenerative medicine. Human hematopoietic stem cell (HSC)-based therapies have been applied to treat leukemic patients for decades. Handling of mesenchymal stem cells (MSCs) has also raised hopes and concerns in the field of tissue engineering. Lately, discovery of cell reprogramming by Yamanaka's team has profoundly modified research strategies and approaches in this domain. As we gain further insight into cell fate mechanisms and identification of key actors and parameters, this also raises issues as to the manipulation of SCs...
2017: Stem Cell Investigation
https://www.readbyqxmd.com/read/28795653/reliability-of-the-sf-36-in-japanese-patients-with-systemic-lupus-erythematosus-and-its-associations-with-disease-activity-and-damage-a-two-consecutive-year-prospective-study
#5
S Baba, Y Katsumata, Y Okamoto, Y Kawaguchi, M Hanaoka, H Kawasumi, H Yamanaka
We aimed to validate the reliability of the Medical Outcomes Study Short Form-36 (SF-36) among Japanese patients with systemic lupus erythematosus (SLE). Japanese patients with SLE ( n = 233) completed the SF-36 and other related demographic questionnaires, and physicians simultaneously completed the SLE Disease Activity Index 2000 (SLEDAI-2K) and the Systemic Lupus International Collaborating Clinics Damage Index (SDI). Patients were prospectively followed for a repeat assessment the following year. The SF-36 subscales demonstrated acceptable internal consistency (Cronbach's α of 0...
January 1, 2017: Lupus
https://www.readbyqxmd.com/read/28789631/efficacy-of-glutathione-for-the-treatment-of-nonalcoholic-fatty-liver-disease-an-open-label-single-arm-multicenter-pilot-study
#6
Yasushi Honda, Takaomi Kessoku, Yoshio Sumida, Takashi Kobayashi, Takayuki Kato, Yuji Ogawa, Wataru Tomeno, Kento Imajo, Koji Fujita, Masato Yoneda, Koshi Kataoka, Masataka Taguri, Takeharu Yamanaka, Yuya Seko, Saiyu Tanaka, Satoru Saito, Masafumi Ono, Satoshi Oeda, Yuichiro Eguchi, Wataru Aoi, Kenji Sato, Yoshito Itoh, Atsushi Nakajima
BACKGROUND: Glutathione plays crucial roles in the detoxification and antioxidant systems of cells and has been used to treat acute poisoning and chronic liver diseases by intravenous injection. This is a first study examining the therapeutic effects of oral administration of glutathione in patients with nonalcoholic fatty liver disease (NAFLD). METHODS: The study was an open label, single arm, multicenter, pilot trial. Thirty-four NAFLD patients diagnosed using ultrasonography were prospectively evaluated...
August 8, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/28782255/pou3f2-participates-in-cognitive-function-and-adult-hippocampal-neurogenesis-via-mammalian-characteristic-amino-acid-repeats
#7
Koichi Hashizume, Masashi Yamanaka, Shintaroh Ueda
POU3F2/BRN-2 is a transcription factor that is mainly expressed in the central nervous system and plays an important role in brain development. The transactivation domain of POU3F2 includes multiple mammalian-characteristic tandem amino acid repeats (homopolymeric amino acid repeats). We previously generated knock-in mice (Pou3f2(Δ)(/Δ) mice) in which all three homopolymeric amino acid repeats were deleted from the Pou3f2 transactivation domain and identified phenotypic impairments in maternal behavior and pup recognition...
August 7, 2017: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/28777837/axial-resolution-and-signal-to-noise-ratio-in-deep-tissue-imaging-with-1-7-%C3%AE-m-high-resolution-optical-coherence-tomography-with-an-ultrabroadband-laser-source
#8
Hiroyuki Kawagoe, Masahito Yamanaka, Norihiko Nishizawa
No abstract text is available yet for this article.
August 1, 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/28774985/complete-genome-sequences-of-getah-virus-strains-isolated-from-horses-in-2016-in-japan
#9
Manabu Nemoto, Hiroshi Bannai, Akihiro Ochi, Hidekazu Niwa, Satoshi Murakami, Koji Tsujimura, Takashi Yamanaka, Hiroshi Kokado, Takashi Kondo
Getah virus is mosquito-borne and causes disease in horses and pigs. We sequenced and analyzed the complete genomes of three strains isolated from horses in Ibaraki Prefecture, eastern Japan, in 2016. They were almost identical to the genomes of strains recently isolated from horses, pigs, and mosquitoes in Japan.
August 3, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28771780/successful-combination-therapy-of-propranolol-and-prednisolone-for-a-case-with-congenital-kasabach-merritt-syndrome
#10
Kento Mizutani, Ai Umaoka, Kenshiro Tsuda, Masato Kakeda, Koji Habe, Keiichi Yamanaka, Megumi Suyama, Hitoshi Mizutani
A male fetus was delivered by cesarean section with a large hemangioma on his right chest and thrombocytopenia. Clinically, Kasabach-Merritt syndrome (KMS) was suspected, and immediately he was treated with daily prednisolone (PSL) 1 mg/kg and recombinant thrombomodulin without response. Additional propranolol (1-3 mg/kg per day) and increased PSL 2 mg/kg per day therapy successfully controlled his disseminated intravascular coagulation and decreased the tumor size without serious side-effects. No relapse of KMS was observed after cease of PSL and propranolol...
August 3, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28765376/reply-to-ferlazzo-and-foray-about-the-space-pup-project
#11
Sayaka Wakayama, Yuko Kamada, Kaori Yamanaka, Takashi Kohda, Hiromi Suzuki, Toru Shimazu, Motoki N Tada, Ikuko Osada, Aiko Nagamatsu, Satoshi Kamimura, Hiroaki Nagatomo, Eiji Mizutani, Fumitoshi Ishino, Sachiko Yano, Teruhiko Wakayama
No abstract text is available yet for this article.
August 15, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28761166/anti-centromere-antibody-exhibits-specific-distribution-levels-among-anti-nuclear-antibodies-and-may-characterize-a-distinct-subset-in-rheumatoid-arthritis
#12
Nobuo Kuramoto, Koichiro Ohmura, Katsunori Ikari, Koichiro Yano, Moritoshi Furu, Noriyuki Yamakawa, Motomu Hashimoto, Hiromu Ito, Takao Fujii, Kosaku Murakami, Ran Nakashima, Yoshitaka Imura, Naoichiro Yukawa, Hajime Yoshifuji, Atsuo Taniguchi, Shigeki Momohara, Hisashi Yamanaka, Fumihiko Matsuda, Tsuneyo Mimori, Chikashi Terao
Anti-centromere antibody (ACA) is one of the classical anti-nuclear antibody (ANA) staining patterns. However, characteristics of ACA in comparison with the other ANA patterns and clinical features of ACA-positive subjects have not been elucidated. Here, we examined all ANA patterns by indirect immunofluorescence for 859 rheumatoid arthritis (RA) patients. Together with the ANA data of 9,575 healthy volunteers, we compared distributions of the ANA levels. ACA was the only ANA that demonstrated a definite bimodal distribution of levels...
July 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28760331/the-applicability-of-new-tnm-classification-for-humanpapilloma-virus-related-oropharyngeal-cancer-in-the-8th-edition-of-the-ajcc-uicc-tnm-staging-system-in-japan-a-single-centre-study
#13
Daisuke Sano, Kenichiro Yabuki, Yasuhiro Arai, Teruhiko Tanabe, Yoshihiro Chiba, Goshi Nishimura, Hideaki Takahashi, Shoji Yamanaka, Nobuhiko Oridate
OBJECTIVE: The purpose of this study is to validate the applicability of new TNM classification for human papillomavirus (HPV)-related oropharyngeal cancer (OPC) in the 8th edition of the American Joint Committee on Cancer (AJCC)/Union for International Cancer Control (UICC) TNM staging system in Japan. METHODS: A total of 91 OPC patients treated with radiation-based therapy between January 2011 and December 2016 were analyzed retrospectively in this study. HPV infection status was evaluated using tumor p16 expression...
July 28, 2017: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/28753554/histone-modification-alteration-coordinated-with-acquisition-of-promoter-dna-methylation-during-epstein-barr-virus-infection
#14
Sayaka Funata, Keisuke Matsusaka, Ryota Yamanaka, Shogo Yamamoto, Atsushi Okabe, Masaki Fukuyo, Hiroyuki Aburatani, Masashi Fukayama, Atsushi Kaneda
Aberrant DNA hypermethylation is a major epigenetic mechanism to inactivate tumor suppressor genes in cancer. Epstein-Barr virus positive gastric cancer is the most frequently hypermethylated tumor among human malignancies. Herein, we performed comprehensive analysis of epigenomic alteration during EBV infection, by Infinium HumanMethylation 450K BeadChip for DNA methylation and ChIP-sequencing for histone modification alteration during EBV infection into gastric cancer cell line MKN7. Among 7,775 genes with increased DNA methylation in promoter regions, roughly half were "DNA methylation-sensitive" genes, which acquired DNA methylation in the whole promoter regions and thus were repressed...
July 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/28752431/effects-of-epigallocatechin-3-gallate-on-systemic-inflammation-induced-cognitive-dysfunction-in-aged-rats
#15
Daiki Yamanaka, Takashi Kawano, Atsushi Nishigaki, Bun Aoyama, Hiroki Tateiwa, Marie Shigematsu-Locatelli, Fabricio M Locatelli, Masataka Yokoyama
PURPOSE: In this study, we examined the effects of epigallocatechin-3-gallate (EGCG), a green tea polyphenol, on sepsis-induced neurocognitive abnormity in aged rats. METHODS: Aged rats received an intraperitoneal (i.p.) injection of 5.0 mg/kg lipopolysaccharide (LPS) or saline. Animals were further divided into three groups: control, low-dose EGCG (4.0 mg/kg), and high-dose EGCG (20 mg/kg). EGCG was i.p. injected at the same time, 24 and 48 h after LPS administration...
July 27, 2017: Journal of Anesthesia
https://www.readbyqxmd.com/read/28745627/spinal-cord-neurons-isolation-and-culture-from-neonatal-mice
#16
Mohamed Eldeiry, Katsuhiro Yamanaka, T Brett Reece, Muhammad Aftab
We present a protocol for the isolation and culture of spinal cord neurons. The neurons are obtained from neonatal C57BL/6 mice and are isolated on postnatal day 1-3. A mouse litter, usually 4-10 pups born from one breeding pair, is gathered for one experiment, and spinal cords are collected individually from each mouse after euthanasia with isoflurane. The spinal column is dissected out and then the spinal cord is released from the column. The spinal cords are then minced to increase the surface area of delivery for an enzymatic protease that allows for the neurons and other cells to be released from the tissue...
July 11, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28744964/specification-of-larval-axes-of-partial-embryos-in-the-temnopleurid-temnopleurus-toreumaticus-and-the-strongylocentroid-hemicentrotus-pulcherrimus
#17
Chisato Kitazawa, Michihiro Nakano, Tadashi Yamaguchi, Chisato Miyahara, Akira Yamanaka
Many sea urchins, including the strongylocentroid Hemicentrotus pulcherrimus, produce an amniotic cavity on the left for adult rudiment formation at the late larval stage. In contrast, temnopleurids form a cell mass at the early larval stage instead of an amniotic cavity. Although the mechanisms establishing left-right polarity of the amniotic cavity involve cell-cell interactions and signaling pathways, corresponding pathways for the cell mass are unknown. We analyzed the effects of blastomere isolation on the specification of larval axes in the temnopleurid Temnopleurus toreumaticus and compared them to those in H...
July 25, 2017: Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution
https://www.readbyqxmd.com/read/28743694/impact-of-surgical-timing-of-postoperative-ocular-motility-in-orbital-blowout-fractures
#18
Yukito Yamanaka, Akihide Watanabe, Chie Sotozono, Shigeru Kinoshita
PURPOSE: To investigate the surgical timing postinjury in regard to ocular motility in patients with orbital-floor blowout fractures. METHODS: This study involved 197 eyes (92 right eyes and 105 left eyes) of 197 patients (154 males and 43 females, mean age: 29.0 years, range: 7-85 years) with pure orbital blowout fractures. All patients underwent surgical repair within 30 days postinjury and were followed up for 3 months or more postoperative (mean follow-up period: 8...
July 25, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28733639/particle-adsorption-on-hydrogel-surfaces-in-aqueous-media-due-to-van-der-waals-attraction
#19
Naoko Sato, Yurina Aoyama, Junpei Yamanaka, Akiko Toyotama, Tohru Okuzono
Particle adhesion onto hydrogels has recently attracted considerable attention because of the potential biomedical applications of the resultant materials. A variety of interactions have been taken advantage of for adsorption, including electrostatic forces, hydrophobic interactions and hydrogen bonding. In this study, we report significant adsorption of submicron-sized silica particles onto hydrogel surfaces in water, purely by van der Waals (vdW) attraction. The vdW forces enabled strong adhesions between dielectric materials in air...
July 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28730715/different-thermotolerances-in-in%C3%A2-vitro-produced-embryos-derived-from-different-maternal-and-paternal-genetic-backgrounds
#20
Miki Sakatani, Kenichi Yamanaka, Ahmed Zaky Balboula, Masashi Takahashi
The present study evaluated the effects of genetic backgrounds on the developmental competence and thermotolerance of bovine in vitro-produced (IVP) embryos. First, Holstein (Hol) and Japanese Black (JB) oocytes were fertilized with sperm from Hol, JB and a thermotolerant breed (Brahman), and in vitro development was evaluated when the embryos were exposed to heat shock on Day 2 (Day 0 = day of fertilization). Sperm genetic backgrounds affected the developmental competence in controls (P < 0.05). Second, the effect of sperm pre-incubation for 4 h on subsequent in vitro fertilization was assessed using different sperm genetic backgrounds...
July 21, 2017: Animal Science Journal, Nihon Chikusan Gakkaihō
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