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https://www.readbyqxmd.com/read/29681540/fgf2-has-distinct-molecular-functions-from-gdnf-in-the-mouse-germline-niche
#1
Kaito Masaki, Mizuki Sakai, Shunsuke Kuroki, Jun-Ichiro Jo, Kazuo Hoshina, Yuki Fujimori, Kenji Oka, Toshiyasu Amano, Takahiro Yamanaka, Makoto Tachibana, Yasuhiko Tabata, Tanri Shiozawa, Osamu Ishizuka, Shinichi Hochi, Seiji Takashima
Both glial cell line-derived neurotrophic factor (GDNF) and fibroblast growth factor 2 (FGF2) are bona fide self-renewal factors for spermatogonial stem cells, whereas retinoic acid (RA) induces spermatogonial differentiation. In this study, we investigated the functional differences between FGF2 and GDNF in the germline niche by providing these factors using a drug delivery system in vivo. Although both factors expanded the GFRA1+ subset of undifferentiated spermatogonia, the FGF2-expanded subset expressed RARG, which is indispensable for proper differentiation, 1...
April 16, 2018: Stem Cell Reports
https://www.readbyqxmd.com/read/29680865/comparison-of-midterm-outcomes-of-transcatheter-aortic-valve-implantation-in-patients-with-and-without-previous-coronary-artery-bypass-grafting
#2
Hideyuki Kawashima, Yusuke Watanabe, Ken Kozuma, Akihisa Kataoka, Makoto Nakashima, Hirofumi Hioki, Fukuko Nagura, Yugo Nara, Shinichi Shirai, Norio Tada, Motoharu Araki, Toru Naganuma, Futoshi Yamanaka, Hiroshi Ueno, Minoru Tabata, Kazuki Mizutani, Akihiro Higashimori, Kensuke Takagi, Masanori Yamamoto, Kentaro Hayashida
The midterm safety and feasibility of transcatheter aortic valve implantation (TAVI) for patients with a history of coronary artery bypass graft (CABG) and high operative risk are unclear. This study compared the midterm outcomes of patients undergoing TAVI with or without previous CABG surgery. Between October 2013 and July 2016, 1,613 patients underwent TAVI according to the Optimized CathEter vAlvular iNtervention (OCEAN)-TAVI registry (previous CABG: n = 120; no previous CABG: n = 1493). The propensity score comprised the variables of the Society of Thoracic Surgeons Score, previous myocardial infarction, peripheral artery disease, chronic kidney disease > stage 2 (estimated glomerular filtration rate < 60 mL/min/1...
April 21, 2018: Heart and Vessels
https://www.readbyqxmd.com/read/29677632/heat-shock-induced-cathepsin-b-activity-during-ivf-and-culture-compromises-the-developmental-competence-of-bovine-embryos
#3
Ken-Ichi Yamanaka, Hafiza Khatun, Junki Egashira, Ahmed Zaky Balboula, Hideki Tatemoto, Miki Sakatani, Naoki Takenouchi, Yasuhiko Wada, Masashi Takahashi
Heat stress can cause significant reproductive dysfunction in mammals and previous studies report that expression and activity of cathepsin B (CTSB), a lysosomal cysteine protease, is negatively correlated with the developmental competence of bovine oocytes and embryos. However, the relationship between heat shock (HS) and CTSB remains largely unknown. Here, we investigated the effects of HS during IVF and early embryonic stages of IVC on CTSB activity and developmental competence in bovine embryos. HS (40 °C for 6 h during IVF and 20 h during IVC) caused a significant increase in CTSB activity irrespective of the developmental stage or duration of HS...
April 6, 2018: Theriogenology
https://www.readbyqxmd.com/read/29676638/identification-of-novel-targets-for-lung-cancer-therapy-using-an-induced-pluripotent-stem-cell-model
#4
Vivek Shukla, Mahadev Rao, Hongen Zhang, Jeanette Beers, Darawalee Wangsa, Danny Wangsa, Floryne O Buishand, Yonghong Wang, Zhiya Yu, Holly Stevenson, Emily Reardon, Kaitlin C McLoughlin, Andrew Kaufman, Eden Payabyab, Julie A Hong, Mary Zhang, Sean R Davis, Daniel C Edelman, Guokai Chen, Markku Miettinen, Nicholas Restifo, Thomas Ried, Paul S Meltzer, David S Schrump
RATIONALE: Despite extensive studies, the genetic and epigenetic mechanisms that mediate initiation and progression of lung cancers have not been fully elucidated. Previously, we have demonstrated that via complementary mechanisms, including DNA methylation, polycomb repressive complexes, and noncoding RNAs, cigarette smoke induces stem-like phenotypes that coincide with progression to malignancy in normal respiratory epithelia as well as enhanced growth and metastatic potential of lung cancer cells...
April 2018: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29674072/extended-internal-standard-method-for-quantitative-1-h-nmr-assisted-by-chromatography-eic-for-analyte-overlapping-impurity-on-1-h-nmr-spectra
#5
Naoki Saito, Yuko Kitamaki, Satoko Otsuka, Noriko Yamanaka, Yuzo Nishizaki, Naoki Sugimoto, Hisanori Imura, Toshihide Ihara
We devised a novel extended internal standard method of quantitative 1 H NMR (qNMR) assisted by chromatography (EIC) that accurately quantifies 1 H signal areas of analytes, even when the chemical shifts of the impurity and analyte signals overlap completely. When impurity and analyte signals overlap in the 1 H NMR spectrum but can be separated in a chromatogram, the response ratio of the impurity and an internal standard (IS) can be obtained from the chromatogram. If the response ratio can be converted into the 1 H signal area ratio of the impurity and the IS, the 1 H signal area of the analyte can be evaluated accurately by mathematically correcting the contributions of the 1 H signal area of the impurity overlapping the analyte in the 1 H NMR spectrum...
July 1, 2018: Talanta
https://www.readbyqxmd.com/read/29673509/incidence-predictors-and-clinical-impact-of-prosthesis-patient-mismatch-following-transcatheter-aortic-valve-replacement-in-asian-patients-the-ocean-tavi-registry
#6
Masaki Miyasaka, Norio Tada, Masataka Taguri, Shigeaki Kato, Yusuke Enta, Tatsushi Otomo, Masaki Hata, Yusuke Watanabe, Toru Naganuma, Motoharu Araki, Futoshi Yamanaka, Shinichi Shirai, Hiroshi Ueno, Kazuki Mizutani, Minoru Tabata, Akihiro Higashimori, Kensuke Takagi, Masanori Yamamoto, Kentaro Hayashida
OBJECTIVES: The authors sought to investigate the prevalence, risk factors, and mid-term mortality in Asian patients with prosthesis-patient mismatch (PPM) after transcatheter aortic valve replacement (TAVR). BACKGROUND: Little information is available on PPM after TAVR in Asian patients. METHODS: The authors included 1,558 patients enrolled in the OCEAN-TAVI (Optimized transCathEter vAlvular iNtervention) Japanese multicenter registry from October 2013 to July 2016 after excluding patients who died following TAVR before discharge...
April 23, 2018: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29671215/a-patient-presenting-with-isolated-hematuria-and-renal-dysfunction-as-rare-manifestation-of-cryoglobulinemic-glomerulonephritis-in-the-course-of-autoimmune-diseases-including-sj%C3%A3-gren-s-syndrome
#7
Masaki Yamanaka, Yoshihide Fujigaki, Hajime Kono, Michito Nagura, Shigeyuki Arai, Yoshifuru Tamura, Tatsuru Ota, Shigeru Shibata, Fukuo Kondo, Yutaka Yamaguchi, Shunya Uchida
Autoimmune diseases are sometimes associated with immune-mediated renal diseases and cryoglobulinemia is one of the causes. Cryoglobulinemia and cryoglobulinemic glomerulonephritis associated with primary Sjögren's syndrome are most frequent condition among non-hepatitis C virus-related condition. Its typical renal manifestation shows high amount of proteinuria with microscopic hematuria and renal insufficiency. We describe a case of 72-year-old woman with Hashimoto disease, autoimmune hepatitis, Sjögren's syndrome, and immune-related pancytopenia complicated by cryoglobulinemic glomerulonephritis...
April 18, 2018: CEN Case Reports
https://www.readbyqxmd.com/read/29667330/no-increased-risk-of-herpes-zoster-in-tnf-inhibitor-and-non-tnf-inhibitor-users-with-rheumatoid-arthritis-epidemiological-study-using-the-japanese-health-insurance-database
#8
Ryoko Sakai, Shoko Kasai, Fumio Hirano, Sayoko Harada, Mari Kihara, Waka Yokoyama, Michi Tsutsumino, Kenji Nagasaka, Ryuji Koike, Hisashi Yamanaka, Nobuyuki Miyasaka, Masayoshi Harigai
OBJECTIVE: It is controversial whether the use of biological disease-modifying antirheumatic drugs (DMARDs) increases the risk of herpes zoster (HZ). We aimed to evaluate the risks of HZ in tumor necrosis factor inhibitor (TNFI) and non-TNFI users with rheumatoid arthritis (RA) over 3 years in Japan. METHOD: Using the Japanese health insurance database, we assigned patients with at least one RA diagnostic code and one prescription for any DMARDs (RA cases) recorded between January 2005 and December 2013 to the RA group...
April 17, 2018: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29665373/human-monoclonal-antibodies-against-west-nile-virus-from-japanese-encephalitis-vaccinated-volunteers
#9
Tatsuhiko Ozawa, Hideyuki Masaki, Tomohiko Takasaki, Ikuko Aoyama, Takahiro Yumisashi, Atsushi Yamanaka, Eiji Konishi, Yoh Ohnuki, Atsushi Muraguchi, Hiroyuki Kishi
West Nile virus (WNV) is a positive-sense single-stranded RNA flavivirus belonging to the Japanese encephalitis virus (JEV) serocomplex of the Flaviviridae family and causes mosquito-borne infections. Although most human infection cases are asymptomatic, approximately one in 150 infected individuals develops meningoencephalitis, with a mortality rate of 4-14%. While the development of human neutralizing antibody therapeutics against WNV is strongly anticipated, WNV is difficult to study in conventional laboratories due to its high safety level requirement...
April 14, 2018: Antiviral Research
https://www.readbyqxmd.com/read/29663886/microrna-regulation-along-the-course-of-cellular-reprogramming-to-pluripotency
#10
M Ishtiaq, M Waseem, R Mehmood
Generation of patient-specific stem cells has been a long-held aim of many developmental biologists. Apart from providing a source for stem cell therapies, these cells have the potential to be utilized in a number of scenarios like disease modeling, drug screening and studying normal development. Various approaches have been used to reprogram terminally differentiated cells to a pluripotent state with varying efficiencies and limitations. The nuclear transfer had been the most successful method for reprogramming until recently...
April 15, 2018: Current Molecular Medicine
https://www.readbyqxmd.com/read/29661500/severity-of-eczema-and-mental-health-problems-in-japanese-schoolchildren-the-tommo-child-health-study
#11
Yasutaka Kuniyoshi, Masahiro Kikuya, Masako Miyashita, Chizuru Yamanaka, Mami Ishikuro, Taku Obara, Hirohito Metoki, Naoki Nakaya, Fuji Nagami, Hiroaki Tomita, Atsushi Hozawa, Ichiro Tsuji, Shigeo Kure, Nobuo Yaegashi, Masayuki Yamamoto, Shinichi Kuriyama
BACKGROUND: The association between eczema and mental health problems in schoolchildren has been underexplored. We aimed to investigate this association with the validated questionnaires. METHODS: Of 46,648 invited children, we analyzed 9954 (21.3%) in the 2nd to the 8th grades from the ToMMo Child Health Study conducted in 2014 and 2015, a cross-sectional survey in Miyagi Prefecture, Japan. We defined eczema status as "normal," "mild/moderate," or "severe," based on the presence of persistent flexural eczema and sleep disturbance, according to the International Study of Asthma and Allergies in Childhood (ISAAC) Eczema Symptom Questionnaire...
April 13, 2018: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/29659903/feasibility-study-of-cancer-genome-alterations-identified-by-next-generation-sequencing-abc-study
#12
Yoichi Naito, Hideaki Takahashi, Kohei Shitara, Wataru Okamoto, Hideaki Bando, Takeshi Kuwata, Yasutoshi Kuboki, Shingo Matsumoto, Izumi Miki, Takeharu Yamanaka, Atsushi Watanabe, Motohiro Kojima
Background: To confirm the feasibility and explore the clinical applicability of amplicon sequencing by next generation sequencing (NGS) of biopsy samples from patients with advanced solid tumors, we conducted a prospective study. Methods: Patients with unresectable, advanced, or recurrent solid tumors were included. Key eligibility criteria were as follows: 20 years or older, any planned systemic therapy, adequate lesion for biopsy, and written informed consent...
April 12, 2018: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29657592/design-and-baseline-characteristics-of-the-xarelto-post-authorization-safety-effectiveness-study-in-japanese-patients-with-atrial-fibrillation-xapass
#13
Satoshi Ogawa, Kazuo Minematsu, Takanori Ikeda, Takanari Kitazono, Jyoji Nakagawara, Susumu Miyamoto, Yuji Murakawa, Yohei Ohashi, Makiko Takeichi, Yutaka Okayama, Satoshi Yamanaka, Lyo Inuyama
Background: The phase III Japanese Rivaroxaban Once-Daily Oral Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation (J-ROCKET AF) showed that the rivaroxaban group had a lower event rate of intracranial bleeding than the warfarin group and that rivaroxaban was noninferior to warfarin for the principal safety outcome. However, safety and effectiveness data from unselected patients with AF in everyday clinical practice in Japan are lacking...
April 2018: Journal of Arrhythmia
https://www.readbyqxmd.com/read/29657141/association-of-serum-soluble-cd163-with-polymyositis-and-dermatomyositis-especially-in-anti-mda5-antibody-positive-cases
#14
Hidenaga Kawasumi, Yasuhiro Katsumata, Akira Nishino, Shinya Hirahara, Yasushi Kawaguchi, Masataka Kuwana, Hisashi Yamanaka
OBJECTIVE: We elucidated the association of serum soluble CD163 (sCD163) with rapidly progressive interstitial lung disease (RP-ILD), autoantibody profiles, and serum ferritin in patients with polymyositis (PM), classic dermatomyositis (DM), and clinical amyopathic dermatomyositis (CADM). METHODS: Serum sCD163 levels were retrospectively measured by ELISA in patients with PM, classic DM, and CADM, as well as in healthy controls (HC). Repeat sera samples were obtained posttreatment from available patients...
April 15, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29627620/efficacy-safety-and-tolerability-of-lubiprostone-for-the-treatment-of-non-alcoholic-fatty-liver-disease-in-adult-patients-with-constipation-the-lubiprone-double-blind-randomised-placebo-controlled-study-design
#15
Takaomi Kessoku, Kento Imajo, Takashi Kobayashi, Yasushi Honda, Takayuki Kato, Yuji Ogawa, Wataru Tomeno, Shingo Kato, Takuma Higurashi, Masato Yoneda, Hiroyuki Kirikoshi, Kazuki Kubota, Masataka Taguri, Takeharu Yamanaka, Haruki Usuda, Koichiro Wada, Satoru Saito, Atsushi Nakajima
BACKGROUND: This paper reports the protocol of a randomised, double-blind, placebo-controlled study to test the efficacy, safety, and tolerability of lubiprostone (LUB) vs. placebo on suppressing gut permeability in non-alcoholic fatty liver disease (NAFLD) patients with constipation. NAFLD, including non-alcoholic steatohepatitis (NASH), is a common chronic liver disorder. Progression is associated with increased gut permeability and gut-derived endotoxins. Most NAFLD/NASH clinical trial drugs aim to improve liver function or systemic metabolism...
April 5, 2018: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29626679/gamma-knife-radiosurgery-for-trigeminal-neuralgia-associated-with-osteogenesis-imperfecta
#16
Yoshiyasu Iwai, Kenichi Ishibashi, Kazuhiro Yamanaka
OBJECTIVE: Trigeminal neuralgia is a rare feature of basilar impression, a complication of osteochondrodysplastic disorders. Microvascular decompression is difficult in medically refractory cases. Gamma knife radiosurgery (GKS) is effective for classical trigeminal neuralgia and we first applied this GKS for a patient suffering from trigeminal neuralgia with basilar impression complicated by osteogenesis imperfecta. CLINICAL PRESENTATION: An 18-year-old man with typeⅠosteogenesis imperfecta presented with a 2-year history of typical left trigeminal neuralgia affecting the ophthalmic, maxillary, and mandibular nerves...
April 4, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29626458/re-expansion-pulmonary-edema-after-asd-closure-through-right-sided-mini-thoracotomy
#17
Keiichi Hirose, Senri Miwa, Hisashi Sakaguchi, Shinya Takimoto, Yukiyo Yoshida, Yohei Onga, Yuichi Tara, Kazuo Yamanaka
We described a case suffering from re-expanded pulmonary edema (RPE) after atrial septal defect (ASD) closure through right-sided mini-thoracotomy. After re-expansion of the right lung after weaning from cardiopulmonary bypass (CPB), a large amount of serous slight-hemorrhagic bronchial secretions spilled out from the right bronchus. Positive pressure ventilation and differential ventilation were used. We found no bleeding and decreased secretions 24 hours after the onset of RPE. She was extubated 42 hours after the operation...
April 4, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29625068/chromatin-accessibility-dynamics-during-chemical-induction-of-pluripotency
#18
Shangtao Cao, Shengyong Yu, Dongwei Li, Jing Ye, Xuejie Yang, Chen Li, Xiaoshan Wang, Yuanbang Mai, Yue Qin, Jian Wu, Jiangping He, Chunhua Zhou, He Liu, Bentian Zhao, Xiaodong Shu, Chuman Wu, Ruiping Chen, Waiyee Chan, Guangjin Pan, Jiekai Chen, Jing Liu, Duanqing Pei
Despite its exciting potential, chemical induction of pluripotency (CIP) efficiency remains low and the mechanisms are poorly understood. We report the development of an efficient two-step serum- and replating-free CIP protocol and the associated chromatin accessibility dynamics (CAD) by assay for transposase-accessible chromatin (ATAC)-seq. CIP reorganizes the somatic genome to an intermediate state that is resolved under 2iL condition by re-closing previously opened loci prior to pluripotency acquisition with gradual opening of loci enriched with motifs for the OCT/SOX/KLF families...
April 5, 2018: Cell Stem Cell
https://www.readbyqxmd.com/read/29624782/a-molecular-pathological-study-of-four-cases-of-ciliated-muconodular-papillary-tumors-of-the-lung
#19
Toshiaki Kataoka, Koji Okudela, Mai Matsumura, Hideaki Mitsui, Takehisa Suzuki, Chihiro Koike, Tomoe Sawazumi, Shigeaki Umeda, Yoko Tateishi, Shoji Yamanaka, Yoshihiro Ishikawa, Hiromasa Arai, Michihiko Tajiri, Kenichi Ohashi
Ciliated muconodular papillary tumors (CMPTs) are a recently categorized benign or low-grade malignant neoplasm that develops in the peripheral lung. Only about 40 cases have been reported to date, and the clinicopathological characteristics have yet to be defined in detail. Here, we present four cases of CMPTs with a focus on their immunohistochemical profiles and driver gene mutations. These tumors were a papillary proliferation of a mixture of ciliated, mucous, and basal cells located in the peripheral lung...
April 6, 2018: Pathology International
https://www.readbyqxmd.com/read/29618277/spinal-fluid-cytokine-levels-and-single-photon-emission-computed-tomography-findings-in-complex-febrile-seizures
#20
Gaku Yamanaka, Yu Ishida, Shinichiro Morichi, Natsumi Morishita, Mika Takeshita, Urabe Tomomi, Mori Tomoko, Shingo Oana, Yasuyo Kashiwagi
In this study, the authors assessed cerebrospinal fluid cytokine levels and single-photon emission computed tomography (SPECT) findings in complex febrile seizures. This study included 23 Japanese patients with complex febrile seizures. Twenty patients underwent SPECT and 12 underwent analysis of cerebrospinal fluid cytokine levels (interleukin [IL]-6, interleukin-10, interleukin-17, interleukin-1β, tumor necrosis factor-α, and interferon-γ); 9 patients underwent both studies. Cerebrospinal fluid cytokine levels were compared between the current complex febrile seizure patients and 30 patients with acute encephalopathy...
January 1, 2018: Journal of Child Neurology
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