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COPD phenotypes

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https://www.readbyqxmd.com/read/28103932/biomarkers-of-extracellular-matrix-turnover-are-associated-with-emphysema-and-eosinophilic-bronchitis-in-copd
#1
Asger Reinstrup Bihlet, Morten Asser Karsdal, Jannie Marie Bülow Sand, Diana Julie Leeming, Mustimbo Roberts, Wendy White, Russell Bowler
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is characterized by airflow obstruction and loss of lung tissue mainly consisting of extracellular matrix (ECM). Three of the main ECM components are type I collagen, the main constituent in the interstitial matrix, type VI collagen, and elastin, the signature protein of the lungs. During pathological remodeling driven by inflammatory cells and proteases, fragments of these proteins are released into the bloodstream, where they may serve as biomarkers for disease phenotypes...
January 19, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28103123/disease-burden-of-patients-with-asthma-copd-overlap-in-a-us-claims-database-impact-of-icd-9-coding-based-definitions
#2
Keele E Wurst, Samantha St Laurent, David Hinds, Kourtney J Davis
The inclusion of an asthma/chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS) population in the 2015 Global Initiative for Chronic Obstructive Lung Disease strategic documents has raised questions about the profile of these patients in clinical practice, as they are mostly excluded from asthma and COPD clinical trials. We estimated the disease burden, co-morbidities, and respiratory treatments of patients with asthma/COPD overlap, utilizing the Truven MarketScan commercial and Medicare databases...
January 19, 2017: COPD
https://www.readbyqxmd.com/read/28089081/asthma-chronic-obstructive-pulmonary-disease-overlap-syndrome-literature-review-and-contributions-towards-a-portuguese-consensus
#3
D Araújo, E Padrão, M Morais-Almeida, J Cardoso, F Pavão, R B Leite, A C Caldas, A Marques
INTRODUCTION: Phenotypic overlap between the two main chronic airway pulmonary diseases, asthma and chronic obstructive pulmonary disease (COPD), has been the subject of debate for decades, and recently the nomenclature of asthma-COPD overlap syndrome (ACOS) was adopted for this condition. The definition of this entity in the literature is, however, very heterogeneous, it is therefore important to define how it applies to Portugal. METHODS: A literature review of ACOS was made in a first phase resulting in the drawing up of a document that was later submitted for discussion among a panel of chronic lung diseases experts, resulting in reflexions about diagnosis, treatment and clinical guidance for ACOS patients...
January 6, 2017: Revista Portuguesa de Pneumologia
https://www.readbyqxmd.com/read/28068996/non-linear-parameters-of-specific-resistance-loops-to-characterise-obstructive-airways-diseases
#4
Marko Topalovic, Vasileios Exadaktylos, Thierry Troosters, Geert Celis, Jean-Marie Aerts, Wim Janssens
BACKGROUND: Specific resistance loops appear in different shapes influenced by different resistive properties of the airways, yet their descriptive ability is compressed to a single parameter - its slope. We aimed to develop new parameters reflecting the various shapes of the loop and to explore their potential in the characterisation of obstructive airways diseases. METHODS: Our study included 134 subjects: Healthy controls (N = 22), Asthma with non-obstructive lung function (N = 22) and COPD of all disease stages (N = 90)...
January 9, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28060702/a-bayesian-nonparametric-model-for-disease-subtyping-application-to-emphysema-phenotypes
#5
James C Ross, Peter J Castaldi, Michael H Cho, Junxiang Chen, Yale Chang, Jennifer G Dy, Edwin K Silverman, George R Washko, Raul San Jose Estepar
We introduce a novel Bayesian nonparametric model that uses the concept of disease trajectories for disease subtype identification. Although our model is general, we demonstrate that by treating fractions of tissue patterns derived from medical images as compositional data, our model can be applied to study distinct progression trends between population subgroups. Specifically, we apply our algorithm to quantitative emphysema measurements obtained from chest CT scans in the COPDGene Study and show several distinct progression patterns...
January 2017: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28053515/gender-differences-in-the-t-cell-profiles-of-the-airways-in-copd-patients-associated-with-clinical-phenotypes
#6
Helena Forsslund, Mingxing Yang, Mikael Mikko, Reza Karimi, Sven Nyrén, Benita Engvall, Johan Grunewald, Heta Merikallio, Riitta Kaarteenaho, Jan Wahlström, Åsa M Wheelock, C Magnus Sköld
T lymphocytes are believed to play an important role in the pathogenesis of chronic obstructive pulmonary disease (COPD). How T cells are recruited to the lungs and contribute to the inflammatory process is largely unknown. COPD is a heterogeneous disease, and discriminating disease phenotypes based on distinct molecular and cellular pathways may provide new approaches for individualized diagnosis and therapies. Bronchoalveolar lavage (BAL) and blood samples were obtained from 40 never-smokers, 40 smokers with normal lung function, and 38 COPD patients...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28047750/we-fg-206-08-pulmonary-functional-imaging-biomarkers-of-nsclc-to-guide-and-optimize-functional-lung-avoidance-radiotherapy
#7
Khadija Sheikh, Dante Pi Capaldi, Douglas A Hoover, David A Palma, Brian P Yaremko, Grace Parraga
PURPOSE: Functional lung avoidance radiotherapy promises optimized therapy planning by minimizing dose to well-functioning lung and maximizing dose to the rest of the lung. Patients with NSCLC commonly present with co-morbid COPD and heterogeneously distributed ventilation abnormalities stemming from emphysema, airways disease, and tumour burden. We hypothesized that pulmonary functional imaging methods may be used to optimize radiotherapy plans to avoid regions of well-functioning lung and significantly improve outcomes like quality-of-life and survival...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28042088/three-loci-allele-combinations-based-on-liver-stomach-cancers-hematencephalon-copd-and-normal-population-a-preliminary-study
#8
Gai Li-Ping, Liu Hui, Cui Jing-Hui, Yu Weijian, Ding Xiao-Dong
The purpose of this study was to examine the specific three loci allele combinations connected with the liver cancers, stomach cancers, hematencephalon and patients with chronic obstructive pulmonary disease (COPD). That is to explore the feasibility of the research methods. We explored different mathematical methods for statistical analyses to assess the association between the genotype and phenotype. At the same time we still analyses the statistical results of three loci allele combinations by difference value method and ratio method...
December 29, 2016: Gene
https://www.readbyqxmd.com/read/28004483/concomitant-elevations-of-mmp-9-ngal-prommp-9-ngal-and-neutrophil-elastase-in-serum-of-smokers-with-chronic-obstructive-pulmonary-disease
#9
Sarra Bchir, Hela Ben Nasr, Sandrine Bouchet, Mohamed Benzarti, Abdelhamid Garrouch, Zouhair Tabka, Santos Susin, Karim Chahed, Brigitte Bauvois
A growing body of evidence points towards smoking-related phenotypic differences in chronic obstructive pulmonary disease (COPD). As COPD is associated with systemic inflammation, we determined whether smoking status is related to serum levels of matrix metalloproteinase-9 (pro- and active MMP-9), neutrophil gelatinase-associated lipocalin (NGAL) and the proMMP-9/NGAL complex in patients with COPD. Serum samples were collected in 100 stable-phase COPD patients (82 smokers, 18 never-smokers) and 28 healthy adults (21 smokers, 7 never-smokers)...
December 22, 2016: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/27995441/integral-health-status-based-cluster-analysis-in-moderate-severe-copd-patients-identifies-three-clinical-phenotypes-relevant-for-treatment-as-usual-and-pulmonary-rehabilitation
#10
Jeannette B Peters, Lonneke M Boer, Johan Molema, Yvonne F Heijdra, Judith B Prins, Jan H Vercoulen
PURPOSE: The purposes of the study are to identify clinical phenotypes that reflect the level of adaptation to the disease and to examine whether these clinical phenotypes respond differently to treatment as usual (TAU) and pulmonary rehabilitation (PR), the latter with its strong emphasis on improving adaptation. METHODS: Clusters were identified by a cluster analysis using data on many subdomains of the four domains of health status (HS) (physiological functioning, functional impairment, symptoms and quality of life) in 160 outpatients with chronic obstructive pulmonary disease (COPD) receiving TAU...
December 19, 2016: International Journal of Behavioral Medicine
https://www.readbyqxmd.com/read/27983888/eosinophilic-and-neutrophilic-airway-inflammation-in-the-phenotyping-of-mild-to-moderate-asthma-and-chronic-obstructive-pulmonary-disease
#11
Katarzyna Górska, Magdalena Paplińska-Goryca, Patrycja Nejman-Gryz, Krzysztof Goryca, Rafał Krenke
Asthma and chronic obstructive pulmonary disease (COPD) are heterogeneous diseases with different inflammatory phenotypes. Various inflammatory mediators play a role in these diseases. The aim of this study was to analyze the neutrophilic and eosinophilic airway and systemic inflammation as the phenotypic characterization of patients with asthma and COPD. Twenty-four patients with asthma and 33 patients with COPD were enrolled in the study. All the patients were in mild-to-moderate stage of disease, and none of them were treated with inhaled corticosteroids...
December 16, 2016: COPD
https://www.readbyqxmd.com/read/27982104/pharmacological-and-genetic-reappraisals-of-protease-and-oxidative-stress-pathways-in-a-mouse-model-of-obstructive-lung-diseases
#12
Tsuyoshi Shuto, Shunsuke Kamei, Hirofumi Nohara, Haruka Fujikawa, Yukihiro Tasaki, Takuya Sugahara, Tomomi Ono, Chizuru Matsumoto, Yuki Sakaguchi, Kasumi Maruta, Ryunosuke Nakashima, Taisei Kawakami, Mary Ann Suico, Yoshitaka Kondo, Akihito Ishigami, Toru Takeo, Ken-Ichiro Tanaka, Hiroshi Watanabe, Naomi Nakagata, Kohei Uchimura, Kenichiro Kitamura, Jian-Dong Li, Hirofumi Kai
Protease-antiprotease imbalance and oxidative stress are considered to be major pathophysiological hallmarks of severe obstructive lung diseases including chronic obstructive pulmonary disease (COPD) and cystic fibrosis (CF), but limited information is available on their direct roles in the regulation of pulmonary phenotypes. Here, we utilized βENaC-transgenic (Tg) mice, the previously established mouse model of severe obstructive lung diseases, to produce lower-mortality but pathophysiologically highly useful mouse model by backcrossing the original line with C57/BL6J mice...
December 16, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27977622/chronic-obstructive-pulmonary-disease-the-impact-of-gender
#13
Deepa Raghavan, Anita Varkey, Thaddeus Bartter
PURPOSE OF REVIEW: Chronic obstructive pulmonary disease (COPD) is a widely prevalent and potentially preventable cause of death worldwide. The purpose of this review is to summarize the influence of gender on various attributes of this disease, which will help physicians provide more personalized care to COPD patients. RECENT FINDINGS: Cultural trends in smoking have morphed the epidemiology of this traditionally male disease. There is an increasing 'disease burden' among women with COPD as suggested by the higher prevalence and slower decline in death rates as compared with men...
December 12, 2016: Current Opinion in Pulmonary Medicine
https://www.readbyqxmd.com/read/27974952/derivation-of-a-test-statistic-for-emphysema-quantification
#14
Gonzalo Vegas-Sanchez-Ferrero, George Washko, Farbod N Rahaghi, Maria J Ledesma-Carbayo, R San José Estépar
Density masking is the de-facto quantitative imaging phenotype for emphysema that is widely used by the clinical community. Density masking defines the burden of emphysema by a fixed threshold, usually between -910 HU and -950 HU, that has been experimentally validated with histology. In this work, we formalized emphysema quantification by means of statistical inference. We show that a non-central Gamma is a good approximation for the local distribution of image intensities for normal and emphysema tissue. We then propose a test statistic in terms of the sample mean of a truncated non-central Gamma random variable...
April 2016: Proceedings of the IEEE International Symposium on Biomedical Imaging: from Nano to Macro
https://www.readbyqxmd.com/read/27965780/manifesto-on-small-airway-involvement-and-management-in-asthma-and-chronic-obstructive-pulmonary-disease-an-interasma-global-asthma-association-gaa-and-world-allergy-organization-wao-document-endorsed-by-allergic-rhinitis-and-its-impact-on-asthma-aria-and-global
#15
F Braido, N Scichilone, F Lavorini, O S Usmani, L Dubuske, L P Boulet, R Mosges, C Nunes, M Sánchez-Borges, I J Ansotegui, M Ebisawa, F Levi-Schaffer, L J Rosenwasser, J Bousquet, T Zuberbier, G Walter Canonica
Evidence that enables us to identify, assess, and access the small airways in asthma and chronic obstructive pulmonary disease (COPD) has led INTERASMA (Global Asthma Association) and WAO to take a position on the role of the small airways in these diseases. Starting from an extensive literature review, both organizations developed, discussed, and approved the manifesto, which was subsequently approved and endorsed by the chairs of ARIA and GA(2)LEN. The manifesto describes the evidence gathered to date and defines and proposes issues on small airway involvement and management in asthma and COPD with the aim of challenging assumptions, fostering commitment, and bringing about change...
2016: Asthma research and practice
https://www.readbyqxmd.com/read/27942210/airflow-obstruction-is-it-asthma-or-is-it-copd
#16
REVIEW
Paola Rogliani, Josuel Ora, Ermanno Puxeddu, Mario Cazzola
Despite the availability of guideline recommendations, diagnostic confusion between COPD and asthma appears common, and often it is very difficult to decide whether the obstruction is caused by asthma or COPD in a patient with airway obstruction. However, there are well-defined features that help in differentiating asthma from COPD in the presence of fixed airflow obstruction. Nonetheless, the presentations of asthma and COPD can converge and mimic each other, making it difficult to give these patients a diagnosis of either condition...
2016: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/27931297/chronic-obstructive-pulmonary-disease-phenotypes-biomarkers-and-prognostic-indicators
#17
Christopher E Brightling
Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease associated with significant morbidity and mortality. Current diagnostic criteria are based on lung function impairment, symptoms, and exacerbation frequency but do not capture the heterogeneity of the disease in terms of the complex pathologic changes that occur within lung, the different airway inflammatory patterns, or the airway microbial ecology. Recognition of the importance of defining the heterogeneity of COPD has led to the identification of important phenotypes with specific biomarkers, treatment responses, and underlying pathophysiologic mechanisms...
November 2016: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/27923983/sex-differences-in-function-and-structure-of-the-quadriceps-muscle-in-chronic-obstructive-pulmonary-disease-patients
#18
Pilar Ausín, Juana Martínez-Llorens, Marina Sabaté-Bresco, Carme Casadevall, Esther Barreiro, Joaquim Gea
Chronic obstructive pulmonary disease (COPD) is a complex disorder with extrapulmonary manifestations. Even though there is some knowledge regarding sex differences in the lung disease, little is known about extrapulmonary manifestations. Our aim was to analyze the specific profile of muscle dysfunction, structure, and biology in COPD women. Twenty-one women and 19 men with stable COPD as well as 15 controls were included. Nutritional status, physical activity, lung and muscle function, exercise capacity, and quality of life were assessed...
December 6, 2016: Chronic Respiratory Disease
https://www.readbyqxmd.com/read/27920515/effect-of-elom-080-on-exacerbations-and-symptoms-in-copd-patients-with-a-chronic-bronchitis-phenotype-a-post-hoc-analysis-of-a-randomized-double-blind-placebo-controlled-clinical-trial
#19
Kai-Michael Beeh, Jutta Beier, Henning Candler, Thomas Wittig
BACKGROUND: Treating symptoms and preventing exacerbations are key components of chronic obstructive pulmonary disease (COPD) long-term management. Recently, a more tailored treatment approach has been proposed, in particular for two well-established clinical phenotypes, frequent exacerbators and chronic bronchitis-dominant COPD. ELOM-080 has demonstrated clinical efficacy in treating symptoms and preventing exacerbations in subjects with chronic bronchitis. However, little is known about the potential effects of ELOM-080 in COPD patients...
2016: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/27909766/association-between-tlr2-tlr4-gene-polymorphisms-and-copd-phenotype-in-a%C3%A2-greek-cohort
#20
A Apostolou, T Kerenidi, A Michopoulos, K I Gourgoulianis, M Noutsias, A E Germenis, M Speletas
BACKGROUND: Considering that the innate immune system plays a pivotal role in the pathogenesis of chronic obstructive pulmonary disease (COPD), we hypothesized that functional single-nucleotide polymorphisms (SNPs) of innate immune genes affect the disease phenotype and prognosis. AIM: To elucidate the contribution of common functional TLR2 and TLR4 SNPs and genotypic deficiency of the mannose-binding lectin (MBL) protein, both as single parameters and in combination, in Greek COPD patients...
December 1, 2016: Herz
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