keyword
MENU ▼
Read by QxMD icon Read
search

COPD phenotypes

keyword
https://www.readbyqxmd.com/read/27896981/meta-analysis-of-continuous-phenotypes-identifies-a-gene-signature-that-correlates-with-copd-disease-status
#1
Madeleine Scott, Francesco Vallania, Purvesh Khatri
The utility of multi-cohort two-class meta-analysis to identify robust differentially expressed gene signatures has been well established. However, many biomedical applications, such as gene signatures of disease progression, require one-class analysis. Here we describe an R package, MetaCorrelator, that can identify a reproducible transcriptional signature that is correlated with a continuous disease phenotype across multiple datasets. We successfully applied this framework to extract a pattern of gene expression that can predict lung function in patients with chronic obstructive pulmonary disease (COPD) in both peripheral blood mononuclear cells (PBMCs) and tissue...
2016: Pacific Symposium on Biocomputing
https://www.readbyqxmd.com/read/27891003/obese-copd-is-associated-with-higher-systemic-inflammation-a-new-copd-phenotype
#2
P A Mahesh
No abstract text is available yet for this article.
November 2016: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/27890994/quantitative-computed-tomography-imaging-in-chronic-obstructive-pulmonary-disease
#3
REVIEW
Lalita Fernandes, Yasmin Fernandes, Anthony Menezes Mesquita
Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease having small airway inflammation, emphysema, and pulmonary hypertension. It is now clear that spirometry alone cannot differentiate each component. Quantitative computed tomography (QCT) is increasingly used to quantify the amount of emphysema and small airway involvement in COPD. Inspiratory CT guides in assessing emphysema while expiratory CT identifies areas of air trapping which is a surrogate of small airway inflammation. By constructing a three-dimensional model of airways, we can also measure the airway wall thickness of segmental and subsegmental airways...
November 2016: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/27886850/cellular-senescence-and-autophagy-in-the-pathogenesis-of-chronic-obstructive-pulmonary-disease-copd-and-idiopathic-pulmonary-fibrosis-ipf
#4
REVIEW
Kazuyoshi Kuwano, Jun Araya, Hiromichi Hara, Shunsuke Minagawa, Naoki Takasaka, Saburo Ito, Kenji Kobayashi, Katsutoshi Nakayama
Aging is associated with impairments in homeostasis. Although aging and senescence are not equivalent, the number of senescent cells increases with aging. Cellular senescence plays important roles in tissue repair or remodeling, as well as embryonic development. Autophagy is a process of lysosomal self-degradation that maintains a homeostatic balance between the synthesis, degradation, and recycling of cellular proteins. Autophagy diminishes with aging; additionally, accelerated aging can be attributed to reduced autophagy...
November 2016: Respiratory Investigation
https://www.readbyqxmd.com/read/27879179/-two-sisters-with-lung-emphysema
#5
I Piscaer, F M E Franssen, N H T Ten Hacken, E F M Wouters, R Janssen
BACKGROUND: α1-antitrypsin is an antiprotease that is mainly produced in the liver; it plays a crucial role in the protection of lung parenchyma against the destructive effects of proteases. Mutations in the α1-antitrypsin gene can cause α1-antitrypsin deficiency. Individuals homozygous for the Z-genotype have drastically lowered serum α1-antitrypsine concentrations and often develop lung emphysema at an early age. CASE DESCRIPTION: A 38-year-old woman and her 43-year-old sister both developed lung emphysema at an early age; this could be attributed to severe α1-antitrypsin deficiency...
2016: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/27878892/influence-of-siglec9-polymorphisms-on-copd-phenotypes-including-exacerbation-frequency
#6
Takeo Ishii, Takashi Angata, Emily S Wan, Michael H Cho, Takashi Motegi, Congxiao Gao, Kazuaki Ohtsubo, Shinobu Kitazume, Akihiko Gemma, Peter D ParÉ, David A Lomas, Edwin K Silverman, Naoyuki Taniguchi, Kozui Kida
BACKGROUND AND OBJECTIVE: The exacerbation-prone phenotype of COPD is particularly important, as exacerbations lead to poor quality of life and disease progression. We previously found that COPD patients who lack Siglec-14, a myeloid cell protein that recognizes bacteria and triggers inflammatory responses, are less prone to exacerbation. We hypothesized that the variations in other SIGLEC genes could also influence COPD exacerbation frequency, and investigated the association between SIGLEC9 polymorphisms and the exacerbation-prone phenotype of COPD...
November 22, 2016: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/27875656/involvement-of-jnk-in-tnf%C3%AE-driven-remodelling
#7
Irene Mj Eurlings, Niki L Reynaert, Cheryl van de Wetering, Scott W Aesif, Evi M Mercken, Rafael de Cabo, Jos L van der Velden, Yvonne M Janssen-Heininger, Emiel F M Wouters, Mieke A Dentener
Lung tissue remodeling in chronic obstructive pulmonary disease (COPD) is characterized by airway wall thickening and/or emphysema. Although the bronchial and alveolar compartments are functionally independent entities, we recently showed comparable alterations in matrix composition comprised of decreased elastin content and increased collagen and hyaluronan contents of alveolar and small airway walls. Out of several animal models tested SPC-TNFα mice showed remodelling in alveolar and airway walls similar to what is observed in COPD patients...
November 22, 2016: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/27874046/body-height-as-risk-factor-for-emphysema-in-copd
#8
Massimo Miniati, Matteo Bottai, Ivana Pavlickova, Simonetta Monti
Pulmonary emphysema is a phenotypic component of chronic obstructive pulmonary disease (COPD) which carries substantial morbidity and mortality. We explored the association between emphysema and body height in 726 patients with COPD using computed tomography as the reference diagnostic standard for emphysema. We applied univariate analysis to look for differences between patients with emphysema and those without, and multivariate logistic regression to identify significant predictors of the risk of emphysema...
November 22, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27845721/airway-epithelial-cell-cilia-and-obstructive-lung-disease
#9
REVIEW
Asma Yaghi, Myrna B Dolovich
Airway epithelium is the first line of defense against exposure of the airway and lung to various inflammatory stimuli. Ciliary beating of airway epithelial cells constitutes an important part of the mucociliary transport apparatus. To be effective in transporting secretions out of the lung, the mucociliary transport apparatus must exhibit a cohesive beating of all ciliated epithelial cells that line the upper and lower respiratory tract. Cilia function can be modulated by exposures to endogenous and exogenous factors and by the viscosity of the mucus lining the epithelium...
November 11, 2016: Cells
https://www.readbyqxmd.com/read/27824270/clinical-characterization-and-treatment-patterns-for-the-frequent-exacerbator-phenotype-in-chronic-obstructive-pulmonary-disease-with-severe-or-very-severe-airflow-limitation
#10
Francesco Blasi, Luca Neri, Stefano Centanni, Franco Falcone, Giuseppe Di Maria
Chronic obstructive pulmonary disease (COPD) patients experiencing several episodes of acute clinical derangement suffer from increased morbidity, mortality, and accelerated decline in lung function. Nevertheless, the relationship between co-morbidity profile and exacerbation rates in the frequent exacerbator phenotype is poorly characterized, and evidence-based management guidelines are lacking. We sought to evaluate the co-morbidity profile and treatment patterns of "frequent exacerbators" with severe or very severe airflow limitation...
November 8, 2016: COPD
https://www.readbyqxmd.com/read/27822028/effect-of-endurance-versus-resistance-training-on-quadriceps-muscle-dysfunction-in-copd-a-pilot-study
#11
Ulrik Winning Iepsen, Gregers Druedal Wibe Munch, Mette Rugbjerg, Anders Rasmussen Rinnov, Morten Zacho, Stefan Peter Mortensen, Niels H Secher, Thomas Ringbaek, Bente Klarlund Pedersen, Ylva Hellsten, Peter Lange, Pia Thaning
INTRODUCTION: Exercise is an important countermeasure to limb muscle dysfunction in COPD. The two major training modalities in COPD rehabilitation, endurance training (ET) and resistance training (RT), may both be efficient in improving muscle strength, exercise capacity, and health-related quality of life, but the effects on quadriceps muscle characteristics have not been thoroughly described. METHODS: Thirty COPD patients (forced expiratory volume in 1 second: 56% of predicted, standard deviation [SD] 14) were randomized to 8 weeks of ET or RT...
2016: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/27806137/correction-distribution-and-outcomes-of-a-phenotype-based-approach-to-guide-copd-management-results-from-the-chain-cohort
#12
(no author information available yet)
[This corrects the article DOI: 10.1371/journal.pone.0160770.].
2016: PloS One
https://www.readbyqxmd.com/read/27805311/differences-in-chronic-obstructive-pulmonary-disease-phenotypes-between-non-smokers-and-smokers
#13
Wonjun Ji, Myoung Nam Lim, So Hyeon Bak, Seok-Ho Hong, Seon-Sook Han, Seung-Joon Lee, Woo Jin Kim, Yoonki Hong
INTRODUCTION AND OBJECTIVES: Although tobacco smoking is a major risk factor for chronic obstructive pulmonary disease (COPD), more than one-fourth of COPD patients are non-smokers. In this cross-sectional study, the differences in COPD phenotypes between non-smokers and smokers in male subjects were investigated and were focused on structural lung changes using a quantitative assessment of computed tomography (CT) images. METHODS: They divided male participants with COPD, from a Korean cohort near a cement plant, into non-smokers and smokers by a cutoff of a 5 pack-year smoking history...
November 2, 2016: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/27800118/manifesto-on-small-airway-involvement-and-management-in-asthma-and-chronic-obstructive-pulmonary-disease-an-interasma-global-asthma-association-gaa-and-world-allergy-organization-wao-document-endorsed-by-allergic-rhinitis-and-its-impact-on-asthma-aria-and-global
#14
F Braido, N Scichilone, F Lavorini, O S Usmani, L Dubuske, L P Boulet, R Mosges, C Nunes, M Sanchez-Borges, I J Ansotegui, M Ebisawa, F Levi-Schaffer, L J Rosenwasser, J Bousquet, T Zuberbier, G Walter Canonica, A Cruz, A Yanez, A Yorgancioglu, D Deleanu, G Rodrigo, J Berstein, K Ohta, P Vichyanond, R Pawankar, S N Gonzalez-Diaz, S Nakajima, T Slavyanskaya, A Fink-Wagner, C Baez Loyola, D Ryan, G Passalacqua, J Celedon, J C Ivancevich, K Dobashi, M Zernotti, M Akdis, S Benjaponpitak, S Bonini, W Burks, L Caraballo, Z Awad El-Sayed, S Fineman, P Greenberger, E Hossny, J A Ortega-Martell, H Saito, M Tang, L Zhang
Evidence that enables us to identify, assess, and access the small airways in asthma and chronic obstructive pulmonary disease (COPD) has led INTERASMA (Global Asthma Association) and WAO to take a position on the role of the small airways in these diseases. Starting from an extensive literature review, both organizations developed, discussed, and approved the manifesto, which was subsequently approved and endorsed by the chairs of ARIA and GA(2)LEN. The manifesto describes the evidence gathered to date and defines and proposes issues on small airway involvement and management in asthma and COPD with the aim of challenging assumptions, fostering commitment, and bringing about change...
2016: World Allergy Organization Journal
https://www.readbyqxmd.com/read/27796796/the-reemergence-of-the-asthma-copd-overlap-syndrome-characterizing-a-syndrome-in-the-precision-medicine-era
#15
REVIEW
Stephanie A Christenson
PURPOSE OF REVIEW: The asthma-COPD overlap syndrome (ACOS) has reemerged in the medical literature. This review addresses our current understanding of ACOS as a clinical and biological entity and how new and existing therapies may be targeted to this group. RECENT FINDINGS: Many studies suggest that ACOS is common and associated with more morbidity than asthma and COPD in general. However, there is no consensus on an ACOS definition, likely due to the heterogeneity of the disease...
November 2016: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/27793198/differences-in-systemic-adaptive-immunity-contribute-to-the-frequent-exacerbator-copd-phenotype
#16
Jasper X Geerdink, Sami O Simons, Rebecca Pike, Hans J Stauss, Yvonne F Heijdra, John R Hurst
BACKGROUND: Some COPD patients are more susceptible to exacerbations than others. Mechanisms underlying these differences in susceptibility are not well understood. We hypothesized that altered cell mediated immune responses may underlie a propensity to suffer from frequent exacerbations in COPD. METHODS: Peripheral blood mononuclear cells (PBMCs) were obtained from 24 stable COPD patients, eight frequent exacerbators (≥3 diary-card exacerbations/year) and 16 infrequent exacerbators (< 3 diary-card exacerbations/year)...
October 28, 2016: Respiratory Research
https://www.readbyqxmd.com/read/27780366/coexisting-copd-in-elderly-asthma-with-fixed-airflow-limitation-assessment-by-dlco-predicted-and-hrct
#17
Tsutomu Tamada, Hisatoshi Sugiura, Tsuneyuki Takahashi, Kazuto Matsunaga, Keiji Kimura, Uichiro Katsumata, Ken Ohta, Masakazu Ichinose
BACKGROUND: Asthma patients with fixed airflow limitation (FL) are theoretically classified into two phenotypes, that is, coexisting chronic obstructive pulmonary disease (COPD) and asthmatic airway remodeling. However, the precise percentages of such patients are not known. OBJECTIVE: To assess the prevalence of patients with both FL and COPD components in elderly asthma. METHODS: We evaluated patients by lung diffusion impairment and emphysematous findings in high-resolution computed tomography (HRCT) as candidates for COPD components, as a multicenter, cross-sectional survey...
October 26, 2016: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/27757028/characterization-of-sputum-biomarkers-for-asthma-copd-overlap-syndrome
#18
Jing Gao, Hiroshi Iwamoto, Jukka Koskela, Harri Alenius, Noboru Hattori, Nobuoki Kohno, Tarja Laitinen, Witold Mazur, Ville Pulkkinen
Asthma-COPD overlap syndrome (ACOS) is a commonly encountered chronic airway disease. However, ACOS is still a consensus-based clinical phenotype and the underlying inflammatory mechanisms are inadequately characterized. To clarify the inflammatory mediatypical for ACOS, five biomarkers, namely interleukin (IL)-13, myeloperoxidase (MPO), neutrophil gelatinase-associated lipocalin (NGAL), chitinase-like protein (YKL-40), and IL-6, were selected. This study hypothesized that sputum biomarkers relevant for airway inflammation in asthma (IL-13), COPD (MPO, NGAL), or in both asthma and COPD (YKL-40, IL-6) could be used to differentiate ACOS from COPD and asthma...
2016: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/27748465/phenomenology-of-copd-interpreting-phenotypes-with-the-eclipse-study
#19
Alberto Papi, Maria Sandra Magnoni, Carmelo Caio Muzzio, Gianmarco Benso, Andrea Rizzi
The Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-points (ECLIPSE) study was a large 3-year observational multicentre international study aimed at defining COPD phenotypes and identifying biomarkers and/or genetic parameters that help to predict disease progression. The study has contributed to a better understanding of COPD heterogeneity, with the characterization of clinically important subtypes/phenotypes of patients, such as the frequent exacerbators or patient with persistent systemic inflammation, who may have different prognosis or treatment requirements...
October 14, 2016: Monaldi Archives for Chest Disease, Archivio Monaldi Per le Malattie del Torace
https://www.readbyqxmd.com/read/27739898/visual-assessment-of-chest-ct-images-is-independently-useful-for-genetic-association-analysis-in-studies-of-chronic-obstructive-pulmonary-disease
#20
Eitan Halper-Stromberg, Michael H Cho, Carla Wilson, Dipti Nevrekar, James D Crapo, George Washko, Raúl San José Estépar, David A Lynch, Edwin K Silverman, Sonia Leach, Peter J Castaldi
RATIONALE: Automated analysis of computed tomographic (CT) lung images for epidemiologic nand genetic association studies is increasingly common, but little is known about the utility of visual versus semi-automated emphysema and airway assessments for genetic association studies. OBJECTIVES: Assess the relative utility of visual versus semi-automated emphysema and airway assessments for genetic association studies. METHODS: A standardized inspection protocol was used to visually assess chest CTs for 1540 non-Hispanic white subjects within the COPDGene Study for the presence and severity of radiographic features representing airway wall thickness and emphysema...
October 14, 2016: Annals of the American Thoracic Society
keyword
keyword
48632
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"