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https://www.readbyqxmd.com/read/29662900/analysis-of-the-clinicopathological-characteristics-and-risk-factors-in-patients-with-lung-cancer-and-chronic-obstructive-pulmonary-disease
#1
Jian-Long Miao, Jing-Jing Cai, Xiao-Feng Qin, Rui-Juan Liu
Objective: To investigate the clinicopathological characteristics and risk factors in patients with lung cancer and COPD. Materials and Methods: We retrospectively reviewed the clinical data of 282 patients with lung cancer, including 174 and 108 patients with and without COPD, respectively. Information on age, sex, smoking status, and histologic type was obtained from medical records. Results: Lung cancer patients with COPD and those with the chronic bronchitis (CB) phenotype had higher smoking indices compared to those without COPD (723...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29629407/new-treatment-options-for-copd-how-do-we-decide-phenotypes-endotypes-or-treatable-traits
#2
Ron Balkissoon
No abstract text is available yet for this article.
January 18, 2018: Chronic Obstructive Pulmonary Diseases: Journal of the COPD Foundation
https://www.readbyqxmd.com/read/29627118/alveolar-and-bronchial-nitric-oxide-in-chronic-obstructive-pulmonary-disease-and-asthma-copd-overlap
#3
Bernardino Alcázar-Navarrete, Francisca Castellano Miñán, Pablo Santiago Díaz, Oliveiro Ruiz Rodríguez, Pedro J Romero Palacios
INTRODUCTION: Exhaled nitric oxide (FENO ) measurements differentiate COPD phenotypes from asthma-COPD overlap (ACO). To date, no study has been conducted to determine whether alveolar and bronchial components differ in this group of patients. METHODS: This was an observational cross-sectional study recruiting ambulatory COPD patients. FENO was measured, differentiating alveolar (CANO ) from bronchial (JawNO ) components using a multiple-flow technique. CANO and JawNO values were compared between eosinophilic COPD patients (defined as ≥ 300 eosinophils/μL in peripheral blood test, or ≥ 2% eosinophils or ≥ 3% eosinophils), and a linear regression analysis was performed to determine clinical and biological variables related to these measurements...
April 4, 2018: Archivos de Bronconeumología
https://www.readbyqxmd.com/read/29617009/correction-differentiation-of-quantitative-ct-imaging-phenotypes-in-asthma-versus-copd
#4
(no author information available yet)
[This corrects the article DOI: 10.1136/bmjresp-2017-000252.].
2018: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/29575948/blood-biomarkers-in-chronic-airways-diseases-and-their-role-in-diagnosis-and-management
#5
Job J M H van Bragt, Susanne J H Vijverberg, Els J M Weersink, Levi B Richards, Anne H Neerincx, Peter J Sterk, Elisabeth H D Bel, Anke H Maitland-van der Zee
The complexity and heterogeneous nature of asthma and chronic obstructive pulmonary disease (COPD) results in difficulties in diagnosing and treating patients. Biomarkers that can identify underlying mechanisms, identify patient phenotypes and to predict treatment response could be of great value for adequate treatment. Areas covered: Biomarkers play an important role for the development of novel targeted therapies in airways disease. Blood biomarkers are relatively non-invasive, easy to obtain and easy to apply in routine care...
March 29, 2018: Expert Review of Respiratory Medicine
https://www.readbyqxmd.com/read/29574168/low-leisure-based-sitting-time-and-being-physically-active-were-associated-with-reduced-odds-of-death-and-diabetes-in-people-with-chronic-obstructive-pulmonary-disease-a-cohort-study
#6
Zoe McKeough, Sonia Wing Mei Cheng, Jennifer Alison, Christine Jenkins, Mark Hamer, Emmanuel Stamatakis
QUESTIONS: In people with chronic obstructive pulmonary disease (COPD), are activity phenotypes (based on physical activity and recreational screen time) associated with mortality and cardiometabolic risk factors? DESIGN: Cohort study. PARTICIPANTS: People with COPD aged≥40years and who were current or ex-smokers were identified from the 2003 Scottish Health Survey. OUTCOME MEASURES: Data were collected regarding demographics, anthropometric measurements, medical history, physical activity, sedentary behaviour, health outcomes, and mortality...
March 21, 2018: Journal of Physiotherapy
https://www.readbyqxmd.com/read/29572511/double-deletion-of-tetraspanins-cd9-and-cd81-in-mice-leads-to-a-syndrome-resembling-accelerated-aging
#7
Yingji Jin, Yoshito Takeda, Yasushi Kondo, Lokesh P Tripathi, Sujin Kang, Hikari Takeshita, Hanako Kuhara, Yohei Maeda, Masayoshi Higashiguchi, Kotaro Miyake, Osamu Morimura, Taro Koba, Yoshitomo Hayama, Shohei Koyama, Kaori Nakanishi, Takeo Iwasaki, Satoshi Tetsumoto, Kazuyuki Tsujino, Muneyoshi Kuroyama, Kota Iwahori, Haruhiko Hirata, Takayuki Takimoto, Mayumi Suzuki, Izumi Nagatomo, Ken Sugimoto, Yuta Fujii, Hiroshi Kida, Kenji Mizuguchi, Mari Ito, Takashi Kijima, Hiromi Rakugi, Eisuke Mekada, Isao Tachibana, Atsushi Kumanogoh
Chronic obstructive pulmonary disease (COPD) has been recently characterized as a disease of accelerated lung aging, but the mechanism remains unclear. Tetraspanins have emerged as key players in malignancy and inflammatory diseases. Here, we found that CD9/CD81 double knockout (DKO) mice with a COPD-like phenotype progressively developed a syndrome resembling human aging, including cataracts, hair loss, and atrophy of various organs, including thymus, muscle, and testis, resulting in shorter survival than wild-type (WT) mice...
March 23, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29566699/integrative-genomics-identifies-new-genes-associated-with-severe-copd-and-emphysema
#8
Phuwanat Sakornsakolpat, Jarrett D Morrow, Peter J Castaldi, Craig P Hersh, Yohan Bossé, Edwin K Silverman, Ani Manichaikul, Michael H Cho
BACKGROUND: Genome-wide association studies have identified several genetic risk loci for severe chronic obstructive pulmonary disease (COPD) and emphysema. However, these studies do not fully explain disease heritability and in most cases, fail to implicate specific genes. Integrative methods that combine gene expression data with GWAS can provide more power in discovering disease-associated genes and give mechanistic insight into regulated genes. METHODS: We applied a recently described method that imputes gene expression using reference transcriptome data to genome-wide association studies for two phenotypes (severe COPD and quantitative emphysema) and blood and lung tissue gene expression datasets...
March 22, 2018: Respiratory Research
https://www.readbyqxmd.com/read/29566027/microrna-expression-in-serum-samples-of-sulfur-mustard-veterans-as-a-diagnostic-gateway-to-improve-care
#9
Sedigheh Gharbi, Shahriar Khateri, Mohammad Reza Soroush, Mehdi Shamsara, Parisa Naeli, Ali Najafi, Eberhard Korsching, Seyed Javad Mowla
Sulfur mustard is a vesicant chemical warfare agent, which has been used during Iraq-Iran-war. Many veterans and civilians still suffer from long-term complications of sulfur mustard exposure, especially in their lung. Although the lung lesions of these patients are similar to Chronic Obstructive Pulmonary Disease (COPD), there are some differences due to different etiology and clinical care. Less is known on the molecular mechanism of sulfur mustard patients and specific treatment options. microRNAs are master regulators of many biological pathways and proofed to be stable surrogate markers in body fluids...
2018: PloS One
https://www.readbyqxmd.com/read/29559773/use-of-clinical-characteristics-to-predict-spirometric-classification-of-obstructive-lung-disease
#10
Steven J Pascoe, Wei Wu, Kathryn A Collison, Linda M Nelsen, Keele E Wurst, Laurie A Lee
Background: There is no consensus on how to define patients with symptoms of asthma and chronic obstructive pulmonary disease (COPD). A diagnosis of asthma-COPD overlap (ACO) syndrome has been proposed, but its value is debated. This study (GSK Study 201703 [NCT02302417]) investigated the ability of statistical modeling approaches to define distinct disease groups in patients with obstructive lung disease (OLD) using medical history and spirometric data. Methods: Patients aged ≥18 years with diagnoses of asthma and/or COPD were categorized into three groups: 1) asthma (nonobstructive; reversible), 2) ACO (obstructive; reversible), and 3) COPD (obstructive; nonreversible)...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29558236/demographic-and-clinical-characteristics-of-copd-patients-at-different-blood-eosinophil-levels-in-the-uk-clinical-practice-research-datalink
#11
Sarah Landis, Robert Suruki, Joe Maskell, Kerina Bonar, Emma Hilton, Chris Compton
Blood eosinophil count may be a useful biomarker for predicting response to inhaled corticosteroids and exacerbation risk in chronic obstructive pulmonary disease (COPD) patients. The optimal cut point for categorizing blood eosinophil counts in these contexts remains unclear. We aimed to determine the distribution of blood eosinophil count in COPD patients and matched non-COPD controls, and to describe demographic and clinical characteristics at different cut points. We identified COPD patients within the UK Clinical Practice Research Database aged ≥40 years with a FEV1 /FVC <0...
March 20, 2018: COPD
https://www.readbyqxmd.com/read/29558165/current-approaches-for-phenotyping-as-a-target-for-precision-medicine-in-copd-management
#12
Jose Luis Lopez-Campos, Stefano Centanni
The study of airway diseases continues to present several challenges for modern medicine. The different disease presentations with variables and overlapping features may result in a real challenge for the clinician. In this context, the concept of precision medicine has started to emerge in order to give answers to some of these challenges from a diagnostic and therapeutic point of view. The main reasons to target for precision medicine in chronic obstructive pulmonary disease (COPD) include that there is variability in the clinical presentation, there is no correlation between the different clinical variables at the patient level, there are a number of relevant clinical variables associated with outcomes, we do have specific therapies for specific patient types, and that there is variability in the clinical response to different therapies...
March 20, 2018: COPD
https://www.readbyqxmd.com/read/29556728/patterns-of-body-composition-relating-to-chronic-respiratory-diseases-among-adults-in-four-resource-poor-settings-in-peru
#13
Grace Trompeter, Matthew R Grigsby, Catherine H Miele, Robert A Wise, Robert H Gilman, J Jaime Miranda, Antonio Bernabe-Ortiz, William Checkley
PURPOSE: Body composition is known to influence the development and progression of chronic respiratory diseases (CRDs). We sought to characterize the unique anthropometric phenotypes that present with asthma, chronic obstructive pulmonary disease (COPD), and chronic bronchitis across four distinct settings in Peru. METHODS: We collected sociodemographic, clinical history, and spirometry data from 2959 participants from Lima, Tumbes, and rural and urban Puno. We compared the prevalence of CRDs among different study sites and described disease phenotypes...
March 20, 2018: Lung
https://www.readbyqxmd.com/read/29550368/asthma-and-copd-overlap-pathophysiology-of-aco
#14
REVIEW
Mari Hikichi, Shu Hashimoto, Yasuhiro Gon
Asthma and COPD appear as a result of different mechanisms triggered by different pathogeneses and although they present different features and symptoms of airway inflammation and airway obstruction, there are also cases that present the features of both asthma and COPD. This type of pathology is known as asthma-COPD overlap syndrome (ACOS). Asthma-COPD overlap is identified in clinical practice by the features that it shares with both asthma and COPD. This is not a definition, but a description for clinical use, as asthma-COPD overlap includes several different clinical phenotypes and there are likely to be several different underlying mechanisms"...
March 14, 2018: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/29545283/integration-of-multi-omics-datasets-enables-molecular-classification-of-copd
#15
Chuan-Xing Li, Craig E Wheelock, C Magnus Sköld, Åsa M Wheelock
Rationale: COPD represents an umbrella diagnosis caused by a multitude of underlying mechanisms, and molecular sub-phenotyping is needed to facilitate the development of molecular diagnostic/prognostic tools and efficacious treatments. Objectives: To investigate whether multi-omics integration improves the accuracy of molecular classification of COPD in small cohorts. Measurements and Results: Nine omics data-blocks (mRNA, miRNA, proteomes, metabolomes) collected from several anatomical locations from 52 female subjects were integrated by similarity network fusion (SNF)...
March 15, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29527842/different-pattern-of-chronic-obstructive-pulmonary-disease-assessment-test-score-between-chronic-bronchitis-and-non-chronic-bronchitis-patients
#16
Sang Hoon Yoo, Jae Ha Lee, Kwang Ha Yoo, Ki Suck Jung, Chin Kook Rhee
BACKGROUND: Chronic bronchitis (CB) is an important phenotype in chronic obstructive pulmonary disease (COPD). The purpose of this study is to evaluate different pattern of COPD assessment test (CAT) score between CB and non-CB patients. METHODS: Patients were recruited from 45 centers in Korea, as part of the Korean COPD Subgroup Study cohort. CB was defined when sputum continued for at least 3 months. RESULTS: Total 958 patients with COPD were eligible for analysis...
March 7, 2018: Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/29527840/increased-risk-of-exacerbation-in-asthma-predominant-asthma-chronic-obstructive-pulmonary-disease-overlap-syndrome
#17
Jisoo Park, Eun Kyung Kim, Mi Ae Kim, Tae Hyung Kim, Jung Hyun Chang, Yon Ju Ryu, Sei Won Lee, Yeon Mok Oh, Suk Joong Yong, Won Il Choi, Kwang Ha Yoo, Ji Hyun Lee
BACKGROUND: Obstructive airway disease patients with increased variability of airflow and incompletely reversible airflow obstruction are often categorized as having asthma-chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS). ACOS is heterogeneous with two sub-phenotypes: asthma-ACOS and COPD-ACOS. The objective of this study was to determine the difference in risk of exacerbation between the two sub-phenotypes of ACOS. METHODS: A total of 223 patients exhibiting incompletely reversible airflow obstruction with increased variability (spirometrically defined ACOS) were enrolled...
March 7, 2018: Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/29514663/proteomic-profiling-of-lung-immune-cells-reveals-dysregulation-of-phagocytotic-pathways-in-female-dominated-molecular-copd-phenotype
#18
Mingxing Yang, Maxie Kohler, Tina Heyder, Helena Forsslund, Hilde K Garberg, Reza Karimi, Johan Grunewald, Frode S Berven, Sven Nyrén, C Magnus Sköld, Åsa M Wheelock
BACKGROUND: Smoking is the main risk factor for chronic obstructive pulmonary disease (COPD). Women with COPD who smoke experienced a higher risk of hospitalization and worse decline of lung function. Yet the mechanisms of these gender-related differences in clinical presentations in COPD remain unknown. The aim of our study is to identify proteins and molecular pathways associated with COPD pathogenesis, with emphasis on elucidating molecular gender difference. METHOD: We employed shotgun isobaric tags for relative and absolute quantitation (iTRAQ) proteome analyses of bronchoalveolar lavage (BAL) cells from smokers with normal lung function (n = 25) and early stage COPD patients (n = 18)...
March 8, 2018: Respiratory Research
https://www.readbyqxmd.com/read/29499758/favorable-longitudinal-change-of-lung-function-in-patients-with-asthma-copd-overlap-from-a-copd-cohort
#19
Hye Yun Park, Suh-Young Lee, Danbee Kang, Juhee Cho, Hyun Lee, Seong Yong Lim, Ho Il Yoon, Seung Won Ra, Ki Uk Kim, Yeon-Mok Oh, Don D Sin, Sang-Do Lee, Yong Bum Park
BACKGROUND: The recognition of asthma-chronic obstructive pulmonary disease (COPD) overlap (ACO) as a distinct phenotype of COPD or asthma has increased. Although ACO has worse clinical features than non-ACO COPD, limited information is available on long-term outcomes of lung function decline for ACO and non-ACO COPD. METHODS: COPD patients with at least 3 years of follow-up were selected from the Korean Obstructive Lung Disease cohort. ACO was defined based on 3 major criteria: 1) airflow limitation in individuals 40 years of age and older, 2) ≥10 pack-years of smoking history, and 3) a history of asthma or bronchodilator response of > 400 mL in forced expiratory volume in 1 s (FEV1 ) at baseline; and at least 1 minor criterion: 1) history of atopy or allergic rhinitis, 2) two separated bronchodilator responses of ≥12% and 200 mL in FEV1 , or 3) peripheral blood eosinophils ≥300 cells/μL...
March 2, 2018: Respiratory Research
https://www.readbyqxmd.com/read/29499062/clinical-and-inflammatory-characteristics-of-asthma-copd-overlap-in-workers-with-occupational-asthma
#20
Iñigo Ojanguren, Gregory Moullec, Jad Hobeika, Marc Miravitlles, Catherine Lemiere
INTRODUCTION: Although Asthma-COPD Overlap (ACO) has been described among populations of subjects with COPD or asthma, ACO has never been described among a population of subjects with occupational asthma (OA). OBJECTIVES: The aims of this study were to: 1. identify ACO in a population of subjects with OA; and 2. compare the clinical characteristics between ACO and OA. METHODS: This retrospective study included all subjects diagnosed with OA between 2000 and 2017 in an OA referral center...
2018: PloS One
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