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https://www.readbyqxmd.com/read/29236342/longitudinal-assessment-of-rabbit-renal-fibrosis-induced-by-unilateral-ureteral-obstruction-using-two-dimensional-susceptibility-weighted-imaging
#1
Jing-Gang Zhang, Zhao-Yu Xing, Ting-Ting Zha, Xiao-Juan Tian, Ya-Nan Du, Jie Chen, Wei Xing
BACKGROUND: Previous studies indicated that two-dimensional-susceptibility weighted imaging (2D-SWI) could serve as a useful biomarker for differentiating the grade of liver fibrosis. PURPOSE: To evaluate the feasibility of 2D-SWI in the dynamic quantification of renal fibrosis in a rabbit model. STUDY TYPE: Longitudinal study. ANIMAL MODEL: Twenty-Four New Zealand White Rabbits including control group (n = 4); and renal fibrosis group (n = 20), by means of a unilateral ureteral obstruction (UUO) model...
December 13, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29236239/abdominal-aorta-and-pelvic-artery-calcifications-on-plain-radiographs-may-predict-mortality-in-chronic-kidney-disease-hemodialysis-and-renal-transplantation
#2
Sinee Disthabanchong, Kotcharat Vipattawat, Bunyong Phakdeekitcharoen, Chagriya Kitiyakara, Vasant Sumethkul
PURPOSE: Vascular calcification is common in chronic kidney disease (CKD) and predicts poor patient outcomes. While computed tomography is the gold standard for evaluation of vascular calcification, plain radiograph offers a simpler and less costly alternative. The calcification of abdominal aorta, iliac and femoral arteries has been evaluated by plain radiograph, but the data on their outcome predictabilities are still limited. The present study investigated the role of abdominal aortic calcification (AAC) and pelvic arterial calcification (PAC) in predicting overall morality in non-dialysis CKD stages 2-5 (CKD 2-5), maintenance hemodialysis (HD) and long-term kidney transplant (KT) patients...
December 13, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/29236222/an-indirect-comparison-of-changes-in-the-impact-of-weight-on-quality-of-life-among-subjects-with-type-2-diabetes-treated-with-antihyperglycemic-agents-in-dual-therapy-with-metformin
#3
Shana B Traina, April Slee, Suzy Van Sanden, Joris Diels
INTRODUCTION: It is important to capture the patient experience with a diabetes treatment in clinical trials; however, use of instruments to assess patient-reported outcomes (PROs) in diabetes trials is inconsistent and results may not be reported alongside primary efficacy data. In lieu of head-to-head data, indirect comparisons can be used to compare competing interventions. In this study, we used indirect comparison methods to assess differences in PRO score changes between canagliflozin and other antihyperglycemic agents as add-on to metformin...
December 13, 2017: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/29235929/the-nomological-network-of-emotion-knowledge-and-emotion-understanding-in-adults-evidence-from-two-new-performance-based-tests
#4
Katja Schlegel, Klaus R Scherer
Emotion understanding, which can broadly be defined as expertise in the meaning of emotion, is a core component of emotional intelligence and facilitates better intra- and interpersonal outcomes. However, to date only very few standard tests to measure emotion understanding in healthy adults exist. Here, we present two new performance-based tests that were developed and are scored based on componential emotion theory and large-scale cross-cultural empirical findings. These instruments intend to measure facets of emotion understanding that are not included in existing tests...
December 13, 2017: Cognition & Emotion
https://www.readbyqxmd.com/read/29235488/nomogram-for-cirrhosis-in-patients-with-chronic-hepatitis-b-a-simple-self-assessed-scale-for-individual-risk-of-cirrhosis
#5
Zhiqiao Zhang, Jing Li, Peng Wang, Tingshan He, Yanling Ouyang, Yiyan Huang
The aim of this retrospective study was to establish a simple self-assessed scale for individual risk of cirrhosis in patients with chronic hepatitis B. A total of 1808 consecutive patients were enrolled and analyzed. According to the results of multivariate logistic regression analysis, a simple nomogram was calculated for cirrhosis. The area under receiver operating characteristic curves (AUROCs) were calculated to compare the diagnostic accuracy of nomogram with aspartate aminotransferase to platelet ratio index (APRI), fibrosis index based on the four factors (FIB-4), and S index...
December 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29235422/-the-importance-of-planning-for-the-future-burden-and-unmet-needs-of-caregivers-in-advanced-heart-failure-a-mixed-methods-study
#6
Sonja McIlfatrick, Leanne C Doherty, Mary Murphy, Lana Dixon, Patrick Donnelly, Kenneth McDonald, Donna Fitzsimons
BACKGROUND: While studies have evaluated caregiver outcomes in heart failure, the burden and support needs when caring for someone with advanced heart failure at the end of life have yet to be outlined. AIM: To identify psychosocial factors associated with caregiver burden and evaluate the support needs of caregivers in advanced heart failure. DESIGN: A sequential mixed methods study comprising two phases: (1) postal survey with advanced heart failure patients and their caregivers and (2) interviews with current and bereaved caregivers...
December 1, 2017: Palliative Medicine
https://www.readbyqxmd.com/read/29235296/-effect-of-astragaloside-%C3%A2-combined-with-panax-notoginseng-saponins-on-cerebral-ischemia-reperfusion-injury-and-study-of-pharmacokinetics-in-rats
#7
Jing-Xian Li, Xiao-Qian Yang, Biao Tang, Xiao-Dan Liu, Ying-Hong Tang, Chang-Qing Deng, Xiao-Ping Huang
The aim is to study the effect of astragaloside Ⅳ (AST Ⅳ) combined with Panax notoginseng saponins (PNS) on cerebral ischemia-reperfusion injury, and to probe the synergistic mechanism through the pharmacokinetics of the four major components such as AST Ⅳ, ginsenoside Rg₁ (Rg₁), ginsenoside Rb₁ (Rb₁), notoginsenoside R₁ (R₁) in cerebral ischemia-reperfusion rats. Following the establishment of cerebral ischemia/reperfusion model in rats by modified suture method, neurological function score, cerebral infarction area and pathomorphology were used to evaluate the pharmacological effect that the combination of AST Ⅳ and PNS antagonized cerebral ischemia-reperfusion injury; the contents of AST Ⅳ, Rg₁, Rb₁, R₁ in rat plasma of different time points were determined with ultra performance liquid chromatography tandem massspectrometry (UPLC-MS/MS), pharmacokinetic parameters were calculated and pharmacokinetics changes of the main effective components were analyzed...
October 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29235189/predictors-of-smoking-cessation-during-pregnancy-a-systematic-review-and-meta-analysis
#8
REVIEW
Muhammad Riaz, Sarah Lewis, Felix Naughton, Michael Ussher
AIM: To identify factors found in the research literature to be associated with smoking cessation in pregnancy. METHODS: Electronic searches of the bibliographic databases of PubMed, EMBASE, PsycINFO, Elsevier, Scopus and ISI Web of Science were conducted to April 2017. All studies reporting factors associated with smoking cessation or continuing smoking during pregnancy were included and systematically reviewed, irrespective of study design. The Newcastle Ottawa Quality Assessment Scale was used to assess the study quality...
December 13, 2017: Addiction
https://www.readbyqxmd.com/read/29235103/dietary-patterns-and-risk-of-recurrence-and-progression-in-non-muscle-invasive-bladder-cancer
#9
Ellen Westhoff, Xifeng Wu, Lambertus A Kiemeney, Seth P Lerner, Yuanqing Ye, Maosheng Huang, Colin P Dinney, Alina Vrieling, Huakang Tu
The association of dietary factors with urinary bladder cancer prognosis has scarcely been investigated, and results of studies conducted to date are inconsistent. We investigated whether empirically derived dietary patterns are associated with risks of recurrence and progression in non-muscle invasive bladder cancer patients. Data from 595 newly diagnosed non-muscle-invasive bladder cancer patients from an ongoing prospective cohort study were used to derive dietary patterns using exploratory factor analysis...
December 13, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29235051/development-of-the-cns-tap-tool-for-the-selection-of-precision-medicine-therapies-in-neuro-oncology
#10
Joseph R Linzey, Bernard L Marini, Amy Pasternak, Cory Smith, Zac Miklja, Lili Zhao, Chandan Kumar-Sinha, Alyssa Paul, Nicholas Harris, Patricia L Robertson, Lindsey M Hoffman, Arul Chinnaiyan, Rajen Mody, Carl Koschmann
The number of targeted therapies utilized in precision medicine are rapidly increasing. Neuro-oncology offers a unique challenge due to the varying blood brain barrier (BBB) penetration of each agent. Neuro-oncologists face a difficult task weighing the growing number of potential targeted therapies and their likelihood of BBB penetration. We developed the CNS TAP Working Group and performed an extensive literature review for the evidence-based creation of the CNS TAP tool, which was retrospectively validated by analyzing brain tumor patients who underwent therapy targeted based on genomic results from an academic sequencing study (MiOncoseq, n = 17) or private molecular profiling (Foundation One, n = 7)...
December 12, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29235037/expression-and-significance-of-cytokeratin-7-a-squamocolumnar-junction-marker-in-head-and-neck-squamous-cell-carcinoma
#11
Mitra Mehrad, William D Dupont, W Dale Plummer, James S Lewis
The favorable features of high-risk human papillomavirus (HPV) in the head and neck are limited to those harboring transcriptionally-active HPV, which occur predominantly in the oropharynx (OP). Factors rendering the OP susceptible to HPV oncogenesis are largely unexplored. The role of cytokeratin 7 (CK7) in predisposition to HPV and cancer in the cervix has been evaluated. However, its significance in the H&N is unknown. CK7 immunohistochemistry was performed on a tissue microarray cohort of OP and non-oropharyngeal (NOP) squamous cell carcinomas (SCC) with known clinical follow-up and HPV E6/7 mRNA status...
December 12, 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/29234745/the-influence-of-repeated-abutment-changes-on-peri-implant-tissue-stability-3-year-post-loading-results-from-a-multicentre-randomised-controlled-trial
#12
Eriberto Bressan, Maria Gabriella Grusovin, Ferdinando D'Avenia, Konrad Neumann, Luca Sbricoli, Giuseppe Luongo, Marco Esposito
PURPOSE: To evaluate the influence of at least three abutment disconnections in conventional loaded implants against placement of a definitive abutment in immediately non-occlusal loaded implants on hard and soft tissue changes. A secondary aim was to evaluate whether the presence of less than 2 mm of keratinised mucosa is associated with increased peri-implant marginal bone loss and soft tissue recessions. MATERIALS AND METHODS: Eighty patients requiring one single crown or one fixed partial prosthesis supported by a maximum of three implants were randomised, after implants were placed with more than 35 Ncm, according to a parallel group design to receive definitive abutments that were loaded immediately (definitive abutment or immediate loading group) or transmucosal abutments, which were delayed loaded after 3 months and removed at least three times: 1...
2017: European Journal of Oral Implantology
https://www.readbyqxmd.com/read/29234544/impact-of-transobturator-vaginal-tape-on-female-stress-urinary-incontinence-and-sexual-function
#13
Tarek Soliman, Hammouda Sherif, Abdallah Fathi, Wael Kandeel, Osama Abdelwahab
Objective: To evaluate the effect of vaginal transobturator tape (TOT) on female stress urinary incontinence (SUI) and sexual function. Patients and methods: In all, 145 patients with SUI underwent TOT repair using the 'outside-in' technique. All patients had been sexually active in the previous 6 months. Patients were evaluated by history, routine laboratory investigations, cough stress test, abdominopelvic ultrasonography, and full urodynamic studies. The preoperative data assessed included: age, parity, body mass index, menopausal status, and Stamey grade of SUI...
December 2017: Arab Journal of Urology
https://www.readbyqxmd.com/read/29234475/a-permutation-approach-to-the-assignment-of-the-configuration-to-diastereomeric-tetrads-by-comparison-of-experimental-and-ab-initio-calculated-differences-in-nmr-data
#14
Przemysław J Boratyński
Scoring permutations of experimental chemical shift deviations and DFT/GIAO calculated deviations of isotropic shieldings for sets of four diastereomers can help to assign their relative configurations. This method was exercised on a set of diastereomeric Cinchona alkaloid derivatives, where 13C NMR data always identified the proper configuration. The presented approach is also an attempt to quantify the assignment by exclusion.
2017: Beilstein Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29234380/compression-of-the-fourth-ventricle-using-a-craniosacral-osteopathic-technique-a-systematic-review-of-the-clinical-evidence
#15
REVIEW
Anna Żurowska, Roksana Malak, Anna Kołcz-Trzęsicka, Włodzimierz Samborski, Małgorzata Paprocka-Borowicz
Compression of the fourth ventricle (CV4) is a well-known osteopathic procedure, utilized by osteopaths, osteopathic physicians, craniosacral therapists, physical therapists, and manual therapists as part of their healthcare practice based on some evidence suggesting impact on nervous system functions. The main objective of the study was to identify randomized controlled trials (RCTs) assessing the clinical benefits of CV4 and to show the evidence supporting clinical prescriptions, guides, and advice in treating...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29234367/the-use-of-herbal-remedies-among-mothers-of-young-children-living-in-the-central-appalachian-region
#16
Monira Alwhaibi, Rashmi Goyat, Kimberly M Kelly
Introduction: Women often use herbal remedies as a complement or alternative to traditional medicine. Guided by the Comprehensive Model of Information Seeking, this study examined use of herbal remedies among mothers of young children living in the Central Appalachian Region. Methods: A cross-sectional study was conducted among mothers of young children (n = 178). The outcome measure of interest was the use of any herbal remedy in the past six months. Two scales were developed to measure information seeking channels and to measure beliefs about the safety/efficacy of herbal remedies...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29234361/a-comparative-study-of-established-z-score-models-for-coronary-artery-diameters-in-181-healthy-korean-children
#17
Kyungguk Ryu, Jeong Jin Yu, Hyun Ok Jun, Eun Jung Shin, Young Hee Heo, Jae Suk Baek, Young-Hwue Kim, Jae-Kon Ko
Purpose: The aim of this study was to investigate the statistical properties of four previously developed pediatric coronary artery z score models in healthy Korean children. Methods: The study subjects were 181 healthy Korean children, whose age ranged from 1 month to 15 years. The diameter of each coronary artery was measured using 2-dimensional echocardiography and converted to the z score in the four models (McCrindle, Olivieri, Dallaire, and Japanese model)...
November 2017: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/29234303/a-study-of-super-refractory-status-epilepticus-from-india
#18
Usha K Misra, Jayantee Kalita, Deepanshu Dubey
Background: Super refractory status epilepticus (SRSE) is an important and recently recognized neurological emergency. Purpose: In view of paucity of studies on SRSE, we report the frequency, etiology and outcome of SRSE. Methods: In a hospital-based observational study during 2013 to 2016, consecutive patients with SRSE [persistence of status epilepticus (SE) for 24 h or more, or recurrence of SE on weaning of intravenous anesthetic] were included...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29234277/investigating-the-usability-and-acute-effects-of-a-bedside-video-console-to-prefrontal-cortical-activity-alterations-a-preclinical-study-in-healthy-elderly
#19
Ruud H Knols, Jaap Swanenburg, Dino De Bon, Federico Gennaro, Martin Wolf, Bernard Krüger, Dominique Bettex, Eling D de Bruin
Elderly people at risk of developing cognitive decline; e.g., following surgery, may benefit from structured, challenging, and repetitive cognitive video training. This study assessed usability and acute effects of a newly developed bedside console (COPHYCON). Fifteen healthy elderly individuals performed a one-time 80-min intervention, including cognitive video games aimed at improving awareness and selective attention. Perceived usefulness and perceived ease of use (Technology Acceptance Model) were assessed together with measures of the achieved game level, reaction times, (in-) correct responses during ALERT and SELECT game play...
2017: Frontiers in Systems Neuroscience
https://www.readbyqxmd.com/read/29233789/predictive-performance-of-four-programmed-cell-death-ligand-1-assay-systems-on-nivolumab-response-in-previously-treated-patients-with-non-small-cell-lung-cancer
#20
Daichi Fujimoto, Yuki Sato, Keiichiro Uehara, Kaori Ishida, Junya Fukuoka, Takeshi Morimoto, Hayato Kawachi, Ryobu Mori, Munehiro Ito, Shunsuke Teraoka, Kazuma Nagata, Atsushi Nakagawa, Kojiro Otsuka, Yukihiro Imai, Keisuke Tomii
INTRODUCTION: Nivolumab has demonstrated efficacy against metastatic non-small cell lung cancer (NSCLC). Four programmed cell death ligand 1 (PD-L1) immunohistochemistry (IHC) assay systems are available for identification of responders among patients with NSCLC, and these assays show some differing characteristics. Accordingly, in this study, we evaluated the ability of these assays to identify responders to nivolumab therapy. METHODS: We retrospectively analyzed patients with previously treated advanced NSCLC, who received nivolumab between January 2016 and September 2016...
December 9, 2017: Journal of Thoracic Oncology
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