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Xiang Tu, Fang Liu, James B Jordan, Xue Feng Ye, Ping Fu, Fei Wang, Sen Zhong
BACKGROUND: Diabetic nephropathy (DN) is the major complication of diabetes; proteinuria is the hall mark of DN. Currently, the treatment for proteinuria is mainly limited to angiotensin converting enzyme (ACE) inhibitors or angiotensin II receptor blockers (ARBs). According to Traditional Chinese Medicine (TCM) theory, Chinese medicinals 'securing essence and tonifying the kidney' may be appropriate for proteinuria. The most promising Chinese medicinals and formulae are introduced in the present study to form a potent formula for DN proteinuria...
July 18, 2013: Trials
Krystyna Czerwińska, Aleksander P Mazurek
Losartan potassium, valsartan, telmisartan, irbesartan, eprosartan mesylate and candesartan cilexitil, the angiotensin II receptor antagonists, were analyzed in bulk substances and in tablets: Lorista tablets 50 mg, Diovan tablets 160 mg, Micardis tablets 20 mg, Aprovel tablets 300 mg, Teveten tablets 600 mg and Blopress tablets 16 mg. The conditions for identification by HPLC method in a gradient system and for determination of those compounds in isocratic systems were developed. The determination was carried out using Zorbax SB-Phenyl column with UV-VIS detector set at 230 nm and the following mobile phases: 0...
November 2011: Acta Poloniae Pharmaceutica
Katherine F Croom, Greg L Plosker
Irbesartan (Aprovel, Avapro, Irbetan, Karvea), an angiotensin II receptor type 1 antagonist, is approved in many countries worldwide for the treatment of hypertension. It is also approved in some regions for the treatment of nephropathy in patients with hypertension and type 2 diabetes mellitus. In adults with essential hypertension, irbesartan is effective at reducing blood pressure (BP) over a 24-hour period with once-daily administration. Irbesartan also slows the progression of renal disease in hypertensive patients with type 2 diabetes, with this effect partly independent of its BP-lowering effect...
2008: Drugs
J Widimský, J Zizka, T Haas
Irbesartan (Aprovel) belongs into the new group drugs for the cardiovascular system which exert an antagonistic effect at the level of angiotensin II, but experimental pilot studies as well as clinical studies draw also attention to the possible therapeutic potential of AT1 receptor blockers in the treatment of chronic heart failure. Irbesartan has a marked antihypertensive effect as is apparent from a recent clinical study in 139 patients with mild and moderate hypertension--implemented in the Czech Republic...
June 2000: Vnitr̆ní Lékar̆ství
Katherine F Croom, Monique P Curran, Karen L Goa, Caroline M Perry
Irbesartan (Avapro, Aprovel) is a potent and selective angiotensin II subtype 1 receptor antagonist indicated for use in patients with hypertension, including those with type 2 diabetes mellitus and nephropathy. Once-daily administration of irbesartan provided 24-hour control of blood pressure (BP). In patients with mild-to-moderate hypertension irbesartan was as effective as enalapril, atenolol and amlodipine, and more effective than valsartan in terms of absolute reduction in BP and response rates. Irbesartan produced a greater reduction in diastolic BP at trough than once-daily losartan, but had a smaller effect than olmesartan; the reduction in systolic BP achieved with irbesartan was similar or greater than that with losartan and similar to that seen with olmesartan...
2004: Drugs
Ie P Svishchenko, A V Kotsiuruba, O F Mehed', O M Bukhanevich, V V Radchenko, N M Hula
We evaluated the alters in plasma vasoconstriction eicosanoids (LTC4, TXB2) and diene conjugates (DC) levels in patients with essential hypertension (EH) after chronic (30 days, 235 mg per day) of irbezartane (inhibitor of ANG II type 1 receptor with prolongation action "Aprovel" from "Sanofi") oral administration. Patients with EH have significantly higher plasma both LTC4, TXB2 and DC levels then healthy controls. This imbalance can be beneficially modulated by chronic irbezartane ("Aprovel") administration...
2002: Fiziolohichnyĭ Zhurnal
Judit Rapi
Hypertension means a basic public health problem in many countries in the world. The therapeutic attempts of the last years did not fulfill the hopes pinned on them, and most of the patients live with blood pressure above the goal value. This is why there is a need for new, more efficient antihypertensive drugs. On the 1st of July, 2001 irbesartan (Aprovel) was introduced in practice in Hungary. The drug belongs to the family of the angiotensin II receptor inhibitors. Several clinical studies were made with irbesartan in order to evaluate its efficiency, tolerability and safety...
May 26, 2002: Orvosi Hetilap
Antonio Coca, Carlos Calvo, Juan García-Puig, Blas Gil-Extremera, Maria T Aguilera, Alejandro de la Sierra, Alberto Martín-Hidalgo, Rafael Marín
BACKGROUND: When blood pressure (BP)-lowering efficacy is assessed by measurements taken in a clinic setting, angiotensin II-receptor antagonists show similar efficacy to angiotensin-converting enzyme inhibitors and better tolerability. A search of MEDLINE to date, however, reveals no randomized, double-blind studies using ambulatory BP monitoring (ABPM) to compare the BP-lowering efficacy of irbesartan and enalapril in a large number of patients ( > 200) with essential hypertension...
January 2002: Clinical Therapeutics
A A Upnitskiĭ, N Iu Khanina, Iu B Belousov
No abstract text is available yet for this article.
2001: Klinicheskaia Meditsina
H Kulbertus
Irbesartan is a novel AT1 subtype angiotensin II receptor antagonist. Blockade of AT1 receptors by irbesartan is not competitive, but "insurmountable". The drug inhibits in a significant dose-dependent manner the maximal contractile response that can be induced by angiotensin II in isolated strips of rabbit aorta. Even high doses of angiotensin II are unable to overcome the AT1 specific receptor blockade. The drug is directly active and requires no prior biotransformation. Its bioavaility after oral administration is excellent (60-80%) and is not altered by meals...
February 1999: Revue Médicale de Liège
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