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postinflammatory hyperpigmentation

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https://www.readbyqxmd.com/read/29731588/resurfacing-of-facial-acne-scars-with-a-new-variable-pulsed-er-yag-laser-in-fitzpatrick-skin-types-iv-and-v
#1
Namitha Chathra, Venkataram Mysore
Introduction: The Er:YAG laser, considered to be less effective than CO2 laser in its traditional form, in its new modulated version has variable pulse technology that is claimed to be superior to the earlier versions of the laser. Aim: The aim of the study was to check efficacy and safety of the new variable square pulse (VSP) Er:YAG laser in the management of acne scar in patients with Fitzpatrick skin types IV and V. Materials and Methods: This retrospective study consisted of 80 patients (Fitzpatrick skin types IV and V) with atrophic and hypertrophic facial acne scars...
January 2018: Journal of Cutaneous and Aesthetic Surgery
https://www.readbyqxmd.com/read/29726114/high-fluence-1064-nm-q-switched-nd-yag-laser-safe-and-effective-treatment-of-caf%C3%A3-au-lait-macules-in-asian-patients
#2
Jin Ok Baek, Il-Joong Park, Kyung Real Lee, Ha Ryeong Ryu, Jeongsoo Kim, Seulki Lee, Yu Ri Kim, Hoon Hur
OBJECTIVES: Café-au-lait macules (CALMs) are benign cutaneous hyperpigmentary disorders. Usually, laser therapies for cosmetic concerns result in more severe side effects in the people of Asian descent than that of Caucasians. Unfortunately, there is no gold standard for the laser treatment of CALMs in skin of people of Asian descent. To investigate the efficacy and safety of a high-fluence 1064-nm Q-switched neodymium-doped yttrium aluminum garnet (Nd:YAG) laser treatment of CALMs in Asian patients...
May 3, 2018: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29642438/sesamol-inhibited-melanogenesis-by-regulating-melanin-related-signal-transduction-in-b16f10-cells
#3
Po-Yuan Wu, Ya-Jhen You, Yi-Jung Liu, Chien-Wei Hou, Chin-Sheng Wu, Kuo-Ching Wen, Chien-Yih Lin, Hsiu-Mei Chiang
Melanin is synthesized through a series of interactions catalyzed by melanogenic enzymes such as tyrosinase, dopachrome tautomerase (tyrosinase-related protein-2; TRP-2), and tyrosinase-related protein-1 (TRP-1). Tyrosinase plays a key role in catalysing the initial and limiting steps of melanogenesis. The melanin that results from melanogenesis has the protective effect of absorbing ultraviolet radiation. However, overproduction of melanin, in addition to altering the appearance of skin, may lead to skin disorders such as melasma, solar lentigo, and postinflammatory hyperpigmentation...
April 7, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29504972/ablative-fractional-carbon-dioxide-laser-combined-with-intense-pulsed-light-for-the-treatment-of-photoaging-skin-in-chinese-population-a-split-face-study
#4
Xue-Ling Mei, Li Wang
Intense pulsed light (IPL) is effective for the treatment of lentigines, telangiectasia, and generalized erythema, but is less effective in the removal of skin wrinkles. Fractional laser is effective on skin wrinkles and textural irregularities, but can induce postinflammatory hyperpigmentation (PIH), especially in Asians. This study evaluated the safety and efficacy of ablative fractional laser (AFL) in combination with IPL in the treatment of photoaging skin in Asians.This study included 28 Chinese women with Fitzpatrick skin type III and IV...
January 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29460435/topical-pimecrolimus-for-paediatric-cutaneous-mastocytosis
#5
J Mashiah, A Harel, C Bodemer, S Hadj-Rabia, I Goldberg, E Sprecher, A Kutz
BACKGROUND: Most cases of paediatric cutaneous mastocytosis (CM) occur before the age of 2 years, and regression occurs in only 67% of children. Given the absence of any specific therapy, CM is usually treated symptomatically. A few publications have reported the beneficial effect of calcineurin inhibitors for CM. AIM: We sought to evaluate the clinical effectiveness and safety profile of topical pimecrolimus cream for the treatment of CM. METHODS: We performed a retrospective study of all diagnosed cases of CM treated with topical pimecrolimus 1% cream between 2013 and 2015...
February 20, 2018: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/29452029/intense-pulsed-light-is-effective-in-treating-postburn-hyperpigmentation-and-telangiectasia-in-chinese-patients
#6
Na Li, Juntao Han, Dahai Hu, Jing Cheng, Hongtao Wang, Yunchuan Wang, Xuekang Yang, Jiaqi Liu, Ting Li, Wenli Zhao
Intense pulsed light (IPL) has been used to treat postinflammatory hyperpigmentation and telangiectasia in Fitzpatrick type I -II skin. However, its therapeutic effects after superficial second-degree burns in Asian populations with Fitzpatrick type III-IV skin are uncertain. Thirty-five Han Chinese patients with facial or hand hyperpigmentation and telangiectasia due to second-degree fire burns received treatment with IPL. Each patient underwent 2-6 treatments over 3-5 weeks. The laser wavelength was 560-615 nm...
February 16, 2018: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/29431372/pigmentation-disorders-diagnosis-and-management
#7
Scott Plensdorf, Maria Livieratos, Nabil Dada
Pigmentation disorders are commonly diagnosed, evaluated, and treated in primary care practices. Typical hyperpigmentation disorders include postinflammatory hyperpigmentation, melasma, solar lentigines, ephelides (freckles), and café au lait macules. These conditions are generally benign but can be distressing to patients. Appropriate dermatologic history, skin examination, and skin biopsy, when appropriate, can help exclude melanoma and its precursors. In addition to addressing the underlying condition, hyperpigmentation is treated with topical agents, chemical peels, cryotherapy, light or laser therapy, or a combination of these methods...
December 15, 2017: American Family Physician
https://www.readbyqxmd.com/read/29344321/fixed-drug-eruption-to-supplement-containing-ginkgo-biloba-and-vinpocetine-a-case-report-and-review-of-related-cutaneous-side-effects
#8
Philip R Cohen
BACKGROUND: Fixed drug eruption is a cutaneous reaction to a systemic agent that typically presents as an annular or oval erythematous patch or blister and subsequently resolves with postinflammatory hyperpigmentation at the site. Ginkgo biloba leaf extract and vinpocetine are nutritional supplements used to enhance memory in patients with dementia and age-related memory impairment conditions such as Alzheimer's disease. PURPOSE: To describe a fixed drug eruption in a man who repeatedly developed pruritus and macular erythema on his distal penile shaft after ingesting a natural product containing Ginkgo biloba and vinpocetine...
October 2017: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/29234719/compression-stockings-as-an-effective-treatment-for-erythema-nodosum-case-series
#9
K B Golisch, S P Gottesman, R J Segal
Erythema nodosum (EN) is a septal panniculitis that is characterized clinically by tender, erythematous, subcutaneous nodules that are predominately localized on the pretibial lower legs. EN affects women more than men and can be idiopathic or secondary to another disease process such as infection or an immune response. Treatment options for erythema nodosum are suboptimal and often involve significant side effects or require a change in lifestyle. We investigated the effects of moderate 20 mmHg to 30 mmHg compression stockings as an alternative treatment method in two female patients with recurrent erythema nodosum...
December 2017: International Journal of Women's Dermatology
https://www.readbyqxmd.com/read/29224032/microneedling-a-new-approach-for-treating-textural-abnormalities-and-scars
#10
Sara Hogan, Mara Weinstein Velez, Omer Ibrahim
Microneedling is a minimally invasive procedure wherein small holes are created across the stratum corneum while keeping the epidermis partially intact. This produces microchannels that increase skin permeability and simultaneously stimulate growth factor release. Since the epidermis is retained, microneedling has less risk of infection, postinflammatory hyperpigmentation, and scarring compared to other resurfacing modalities. This is a review of the literature on microneedling in the treatment of textural abnormalities, specifically rhytides, scars, and striae...
December 2017: Seminars in Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29222629/postinflammatory-hyperpigmentation-epidemiology-clinical-presentation-pathogenesis-and-treatment
#11
REVIEW
Bridget P Kaufman, Taulun Aman, Andrew F Alexis
Postinflammatory hyperpigmentation (PIH) is a reactive hypermelanosis that develops following cutaneous inflammation. Common causes of PIH include intrinsic skin conditions (e.g., acne and eczema) as well as external insults to the skin, such as burn injuries and dermatologic procedures. PIH more commonly occurs in individuals with darker skin, for whom it is often a source of significant psychological distress. Several therapeutic modalities are available for the treatment of PIH, including topical agents, chemical peels, and energy-based devices...
December 8, 2017: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/29200759/increased-skin-irritation-by-hydroquinone-and-rsetinoic-acid-used-in-combination
#12
Gwang Hoon Kim, Kyung Ah Cheong, Ai-Young Lee
Background: Hydroquinone (HQ) is frequently combined with retinoic acid (RA) to enhance lightening efficacy, which may also affect skin irritancy. Although skin irritation leads to postinflammatory hyperpigmentation, little research has been performed to compare skin irritancy between each component and the combination. Objective: This study was done to examine whether HQ-RA combination increased skin irritation induced by HQ or RA alone. Methods: Patch testing was performed using maximum therapeutic and higher concentrations of HQ and RA in 10 volunteers, and then, it was performed using their popular therapeutic concentrations and combination in the other 20 volunteers...
December 2017: Annals of Dermatology
https://www.readbyqxmd.com/read/29064976/considerations-when-treating-cosmetic-concerns-in-men-of-color
#13
REVIEW
Olabola Awosika, Cheryl M Burgess, Pearl E Grimes
BACKGROUND: Men of color include a diverse population encompassing individuals with Fitzpatrick skin Types IV through VI. Yet, there is a paucity of data describing the cosmetic concerns of this population. OBJECTIVE: To review the basic science of advantages and disadvantages of skin of color and pathophysiology, incidence, and treatment of disorders of cosmetic concern in men of color. METHODS: A MEDLINE search was performed for publications on sex and racial differences in basic science of skin, common disorders in men of color, and evidence-based treatments...
November 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28954099/psychosocial-impact-of-acne-and-postinflammatory-hyperpigmentation
#14
Katlein França, Jonette Keri
Background: Acne is one of the most common skin diseases. It has significant effect on self-image and negative impact on quality of life. Postinflammatory hyperpigmentation is an acquired hypermelanosis that occurs after a skin injury or cutaneous inflammation. It is common sequelae in acne patients. Objectives: This study aimed to investigate the psychosocial impact of acne and postinflammatory hyperpigmentation among patients treated in a dermatology outpatient clinic at the University of Miami Hospital...
July 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28920474/the-state-of-ethnic-dermatology-in-canada
#15
Boluwaji Ogunyemi, Yvette Miller-Monthrope
Approximately 30% of Canadians will be members of a visible minority by 2031. When dermatology became an independent medical discipline in the late 18th and early 19th centuries, most residents of Canada and the United States were of Northern European descent. Morphology and descriptions of dermatoses are based on patients with light skin. Skin of colour dermatology refers to a unique field in dermatology dedicated to the diagnosis and management of disorders that are more prevalent in patients with moderately to richly pigmented skin...
September 2017: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/28917452/postinflammatory-hyperpigmentation-a-comprehensive-overview-treatment-options-and-prevention
#16
REVIEW
Suteeraporn Chaowattanapanit, Narumol Silpa-Archa, Indermeet Kohli, Henry W Lim, Iltefat Hamzavi
Postinflammatory hyperpigmentation (PIH) occurs after various dermatoses, exogenous stimuli, and dermatologic procedures. The clinical course of PIH is chronic and unpredictable, although the probability of resolution of epidermal hyperpigmentation is better than those of dermal hyperpigmentation. PIH can be prevented or alleviated. When it does occur, the underlying inflammatory conditions should be sought and treated as the first step to reduce the progression of inflammation and PIH (which is an inflammatory consequence)...
October 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28917451/postinflammatory-hyperpigmentation-a-comprehensive-overview-epidemiology-pathogenesis-clinical-presentation-and-noninvasive-assessment-technique
#17
REVIEW
Narumol Silpa-Archa, Indermeet Kohli, Suteeraporn Chaowattanapanit, Henry W Lim, Iltefat Hamzavi
Postinflammatory hyperpigmentation (PIH) commonly occurs after various endogenous and exogenous stimuli, especially in dark-skinned individuals. PIH is one of the most common complications of procedures performed using laser and other light sources. The severity of PIH is determined by the inherent skin color, degree and depth of inflammation, degree of dermoepidermal junction disruption, inflammatory conditions, and the stability of melanocytes, leading to epidermal and dermal melanin pigment deposition...
October 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28792112/a-pilot-study-of-treatment-of-striae-distensae-with-variable-square-pulse-erbium-yag-laser-resurfacing
#18
Rungsima Wanitphakdeedecha, Walailak Meeprathom, Woraphong Manuskiatti
BACKGROUND: Striae distensae (SD) are a frequent skin condition for which treatment remains a challenge. Various laser treatments have been employed to remove the epidermis and cause dermal wound and heating with subsequent dermal collagen remodeling. OBJECTIVE: To determine the efficacy and safety of a variable square pulse Erbium: YAG (VSP Er:YAG) laser for the treatment of striae in skin phototypes III-IV. METHODS: Twenty-one women with SD were treated monthly for 2 months with VSP Er:YAG laser resurfacing using a 7-mm spot size...
December 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28790335/involvement-of-transient-receptor-potential-cation-channel-member-a1-activation-in-the-irritation-and-pain-response-elicited-by-skin-lightening-reagent-hydroquinone
#19
Yan Tai, Chuan Wang, Zhihua Wang, Yi Liang, Junying Du, Dongwei He, Xiaoyan Fan, Sven-Eric Jordt, Boyi Liu
Hydroquinone (HQ) is one of the most frequently used and effective skin-lightening products to treat skin hyperpigmentation disorders, including postinflammatory hyperpigmentation, melasma and solar lentigines. HQ is also widely used in cosmetic products for skin whitening. However, HQ treatment can evoke substantial skin irritation, a side effect that remains poorly understood. Here we demonstrate that HQ is an activator of the peripheral irritant receptor transient receptor potential (TRP) cation channel member A1 (TRPA1)...
August 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28690515/a-case-of-facial-partial-unilateral-lentiginosis-treated-with-low-fluence-1-064-nm-q-switched-neodymium-doped-yttrium-aluminum-garnet-laser
#20
En Hyung Kim
Partial unilateral lentiginosis (PUL) is an unusual pigmentary disorder characterized by numerous lentigines grouped within an area of normal skin. Although treatment is not necessary, many patients with facial PUL seek medical help for cosmetic reasons. There is no established standard treatment for PUL. Conventional lasers may cause postinflammatory hyperpigmentation because keratinocytes are injured during the process. Also, scarring, long downtime, and pain are important issues. A 19-year-old patient with facial PUL was successfully treated with low-fluence 1,064-nm Q-switched neodymium-doped yttrium aluminum garnet (QS Nd:YAG) laser...
May 2017: Case Reports in Dermatology
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