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azelaic acid

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https://www.readbyqxmd.com/read/27897372/azelaic-acid-20%C3%A2-cream-effects-on-quality-of-life-and-disease-severity-in-adult-female-acne-patients
#1
Julius Thomas Kainz, Gabriele Berghammer, Piet Auer-Grumbach, Verena Lackner, Sylvia Perl-Convalexius, Rodica Popa, Barbara Wolfesberger
BACKGROUND: Data on the efficacy of acne treatments and their impact on quality of life (QoL) in adult patients is sketchy. OBJECTIVE: Assessment of the efficacy of azelaic acid 20 % cream (Skinoren(®) ) on acne severity and disease-related QoL. PATIENTS AND METHODS: Noninterventional study in adult female patients with mild to moderate acne. Efficacy variables included DLQI and acne severity on the face, chest, and back using the Investigator's Global Assessment (IGA) scale (grade 1 = nearly clear skin; 2 = mild acne; 3 = moderate acne)...
November 29, 2016: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/27874885/patient-reported-outcomes-of-azelaic-acid-foam-15-for-patients-with-papulopustular-rosacea-secondary-efficacy-results-from-a-randomized-controlled-double-blind-phase-3-trial
#2
Stephen Tyring, James A Solomon, Gerald Staedtler, Jason P Lott, Richard Nkulikiyinka, Kaweh Shakery
Patient-reported treatment outcomes are important for evaluating the impact of drug therapies on patient experience. A randomized, double-blind, vehicle-controlled, parallel-group, multicenter, phase 3 study was conducted in 961 participants to assess patient perception of efficacy, utility, and effect on quality of life (QOL) of an azelaic acid (AzA) 15% foam formulation for the treatment of papulopustular rosacea (PPR). Secondary end points included patient-reported global assessment of treatment response, global assessment of tolerability, and opinion on cosmetic acceptability and practicability of product use...
October 2016: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/27869379/rosacea-management-update-on-general-measures-and-topical-treatment-options
#3
M Schaller, H Schöfer, B Homey, M Hofmann, U Gieler, P Lehmann, T A Luger, T Ruzicka, M Steinhoff
Although there is presently no cure for rosacea, there are several recommended treatment options available to control many of the symptoms and to prevent them from getting worse. In addition to self-help measures like avoidance of trigger factors and proper skin care, rosacea management should include topical medications as one of the first-line choices for patients with erythematous and mild to severe papulopustular rosacea. Since mixed forms of characteristic rosacea symptoms are more common, medical treatment must be symptom-tailored for each individual case and will often involve a combination therapy...
December 2016: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/27845778/identification-of-sex-specific-urinary-biomarkers-for-major-depressive-disorder-by-combined-application-of-nmr-and-gc-ms-based-metabonomics
#4
P Zheng, J-J Chen, C-J Zhou, L Zeng, K-W Li, L Sun, M-L Liu, D Zhu, Z-H Liang, P Xie
Women are more vulnerable to major depressive disorder (MDD) than men. However, molecular biomarkers of sex differences are limited. Here we combined gas chromatography-mass spectrometry (GC-MS)- and nuclear magnetic resonance (NMR)-based metabonomics to investigate sex differences of urinary metabolite markers in MDD, and further explore their potential of diagnosing MDD. Consequently, the metabolite signatures of women and men MDD subjects were significantly different from of that in their respective healthy controls (HCs)...
November 15, 2016: Translational Psychiatry
https://www.readbyqxmd.com/read/27843919/rosacea-management
#5
REVIEW
Manal Abokwidir, Steven R Feldman
BACKGROUND: Rosacea is a chronic inflammatory skin condition associated with four distinct subtypes: erythematotelangiectatic, papulopustular, phymatous, and ocular. PURPOSE: To review the different kinds of management for all subtypes. METHODS: We divided rosacea management into three main categories: patient education, skin care, and pharmacological/procedural interventions. RESULTS: Flushing is better prevented rather than treated, by avoiding specific triggers, decreasing transepidermal water loss by moisturizers, and blocking ultraviolet light...
September 2016: Skin Appendage Disorders
https://www.readbyqxmd.com/read/27814413/investigator-reported-efficacy-of-azelaic-acid-foam-15-in-patients-with-papulopustular-rosacea-secondary-efficacy-outcomes-from-a-randomized-controlled-double-blind-phase-3-trial
#6
James A Solomon, Stephen Tyring, Gerald Staedtler, Meike Sand, Richard Nkulikiyinka, Kaweh Shakery
Papulopustular rosacea (PPR) is characterized by centrofacial papules and pustules commonly associated with erythema. To compare investigator-reported efficacy outcomes for azelaic acid (AzA) foam 15% versus vehicle foam in PPR, a randomized, vehicle-controlled, double-blind phase 3 clinical trial was conducted at 48 US sites. Participants received AzA foam or vehicle foam for 12 weeks. Secondary efficacy outcomes included change in inflammatory lesion count (ILC), therapeutic response rate according to investigator global assessment (IGA), and change in erythema rating...
September 2016: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/27803705/profiling-of-altered-metabolomic-states-in-nicotiana-tabacum-cells-induced-by-priming-agents
#7
Msizi I Mhlongo, Paul A Steenkamp, Lizelle A Piater, Ntakadzeni E Madala, Ian A Dubery
Metabolomics has developed into a valuable tool for advancing our understanding of plant metabolism. Plant innate immune defenses can be activated and enhanced so that, subsequent to being pre-sensitized, plants are able to launch a stronger and faster defense response upon exposure to pathogenic microorganisms, a phenomenon known as priming. Here, three contrasting chemical activators, namely acibenzolar-S-methyl, azelaic acid and riboflavin, were used to induce a primed state in Nicotiana tabacum cells. Identified biomarkers were then compared to responses induced by three phytohormones-abscisic acid, methyljasmonate, and salicylic acid...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27785887/exploration-of-biomarkers-for-amoxicillin-clavulanate-induced-liver-injury-multi-omics-approaches
#8
J Lee, S C Ji, B Kim, S Yi, K H Shin, J Y Cho, K S Lim, S H Lee, S H Yoon, J Y Chung, K S Yu, H S Park, S H Kim, I J Jang
To explore potential biomarkers for amoxicillin/clavulanate-induced liver injury (AC-DILI), we conducted a clinical trial in 32 healthy subjects based on multi-omics approaches. Every subject was administered amoxicillin/clavulanate for 14 days. The liver-specific microRNA-122 (miR-122) level increased prior to and correlated well with the observed alanine aminotransferase (ALT) level increase. This result indicates its potential as a sensitive early marker for AC-DILI. We also identified urinary metabolites, such as azelaic acid and 7-methylxanthine, with levels that significantly differed among the groups classified by ALT elevation level on day 8 after drug administration (P < 0...
October 26, 2016: Clinical and Translational Science
https://www.readbyqxmd.com/read/27754504/dietary-fibers-influence-the-intestinal-scfas-and-plasma-metabolites-profiling-in-growing-pigs
#9
W Wu, J Xie, H Zhang
Dietary fibers (DFs), widely used as food additives to replace fat, can benefit metabolic disorders. Soluble and highly fermentable inulin (INU) and insoluble and less fermentable microcrystalline cellulose (MCC) have hypolipidemic or cholesterol-lowering effects, respectively. The current study was aimed at identifying plasma metabolite signatures and metabolic pathways associated with inclusion of DFs with different physiochemical properties, which will lead to a better understanding of functional pathways for DFs to improve metabolic health...
October 18, 2016: Food & Function
https://www.readbyqxmd.com/read/27696206/molecular-recognition-of-azelaic-acid-and-related-molecules-with-dna-polymerase-i-investigated-by-molecular-modeling-calculations
#10
Jakaria Shawon, Akib Mahmud Khan, Adhip Rahman, Mohammad Mazharol Hoque, Mohammad Abdul Kader Khan, Mohammed G Sarwar, Mohammad A Halim
Molecular recognition has central role on the development of rational drug design. Binding affinity and interactions are two key components which aid to understand the molecular recognition in drug-receptor complex and crucial for structure-based drug design in medicinal chemistry. Herein, we report the binding affinity and the nonbonding interactions of azelaic acid and related compounds with the receptor DNA polymerase I (2KFN). Quantum mechanical calculation was employed to optimize the modified drugs using B3LYP/6-31G(d,p) level of theory...
October 1, 2016: Interdisciplinary Sciences, Computational Life Sciences
https://www.readbyqxmd.com/read/27645210/role-of-plasmodesmata-and-plasmodesmata-localizing-proteins-in-systemic-immunity
#11
Gah-Hyun Lim, Aardra Kachroo, Pradeep Kachroo
Systemic acquired resistance (SAR) is a highly desirable form of resistance that protects against a broad-spectrum of pathogens. SAR involves the generation of a mobile signal at the site of primary infection, which arms distal portions of a plant against subsequent secondary infections. A number of diverse chemical signals contributing to SAR have been isolated and characterized. Among these, salicylic acid (SA) functions in parallel to azelaic acid (AzA) and glycerol-3-phosphate (G3P), and both AzA and G3P function downstream of the free radicals nitric oxide and reactive oxygen species...
September 2016: Plant Signaling & Behavior
https://www.readbyqxmd.com/read/27608295/metabolomic-profiling-of-brain-from-infants-who-died-from-sudden-infant-death-syndrome-reveals-novel-predictive-biomarkers
#12
S F Graham, O P Chevallier, P Kumar, O Türko Gcaron Lu, R O Bahado-Singh
OBJECTIVE: Sudden Infant Death Syndrome (SIDS) is defined as the sudden death of an infant <1 year of age that cannot be explained following a thorough investigation. Currently, no reliable clinical biomarkers are available for the prediction of infants who will die of SIDS. STUDY DESIGN: This study aimed to profile the medulla oblongata from postmortem human brain from SIDS victims (n=16) and compare their profiles with that of age-matched controls (n=7). RESULTS: Using LC-Orbitrap-MS, we detected 12 710 features in electrospray ionization positive (ESI+) mode and 8243 in ESI- mode from polar extracts of brain...
September 8, 2016: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/27564527/exploration-of-candidate-biomarkers-for-human-psoriasis-based-on-gc-ms-serum-metabolomics
#13
H Kang, X Li, Q Zhou, S Quan, F Xue, J Zheng, Y Yu
BACKGROUND: Recent studies have shown that dysregulated metabolic pathways are linked to psoriasis pathogenesis. However, an extensive, unbiased metabolic analysis in psoriatic patients has not been completely explored. The metabolome represents the end products of proteomics or cellular processes which may be closely associated with the pathogenesis of psoriasis. OBJECTIVES: To determine the differences in serum metabolomic profiles among psoriasis patients and healthy controls with the goal of identifying potential biomarkers in patients with psoriasis...
August 26, 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/27537212/facial-dermatitis-and-rosacea
#14
Joseph F Fowler
Rosacea is a chronic skin disorder associated with flushing, erythema, dryness, burning and stinging, and inflammatory papules and pustules. New treatments available or in development target the inflammatory and erythematous components of the disease. These agents include the selective α2 receptor agonist brimonidine, the topical agents ivermectin cream 1% and azelaic acid foam 15%, and use of tetracyclinetype antibiotics, which affect the cathelicidin pathway. Semin Cutan Med Surg 35(supp6):S107-S109.
June 2016: Seminars in Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/27504249/the-efficacy-safety-and-tolerability-of-ivermectin-compared-with-current-topical-treatments-for-the-inflammatory-lesions-of-rosacea-a-network-meta-analysis
#15
Kashif Siddiqui, Linda Stein Gold, Japinder Gill
BACKGROUND: Rosacea is a common chronic skin condition that manifests as recurrent inflammatory lesions. Long-term treatment is required to control symptoms and disease progression, with topical treatments being the first-line choice. Ivermectin 1 % cream is a new once-daily (QD) topical treatment for the inflammatory lesions of rosacea, and it is important to compare the efficacy, safety, and tolerability of ivermectin with other currently available topical treatments. METHODS: A systematic literature review was performed from January 2011 to June 2015, with articles published prior to 2011 retrieved from a Cochrane review on rosacea...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27500896/combination-of-glycolic-acid-peel-and-topical-20-azelaic-acid-cream-in-melasma-patients-efficacy-and-improvement-in-quality-of-life
#16
Surabhi Dayal, Priyadarshini Sahu, Ruchika Dua
BACKGROUND: Glycolic acid (GA) peel is one of the most versatile agents in the treatment of melasma. GA peeling alone or in combination with topical hypopigmenting agents has shown encouraging results. However, there is paucity of controlled trial demonstrating the efficacy of glycolic peel in conjunction with topical azelaic acid (AA). We therefore sought to highlight the efficacy and safety of this combination in melasma. OBJECTIVE: To assess the clinical efficacy, safety and reduction in melasma quality of life (MELASQOL) scores on combining serial GA peels with topical 20% AA cream in epidermal melasma...
August 8, 2016: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/27484346/new-effective-azelaic-acid-liposomal-gel-formulation-of-enhanced-pharmaceutical-bioavailability
#17
E Burchacka, P Potaczek, P Paduszyński, K Karłowicz-Bodalska, T Han, S Han
Azelaic acid is a naturally occurring saturated C9-dicarboxylic acid which has been shown to be effective in the treatment of comedonal acne and inflammatory acne, as well as hiperpigmentary skin disorders. The aim of the present study is to compare new developed liposomal hydrogel (lipogel) and commercially available product in terms of the active substance-azelaic acid bioavailability. Topical formulations were evaluated for physical parameters, such as pH measurement, organoleptic evaluation and liposome size analysis in lipogel formulation...
July 30, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27435665/very-low-dose-isotretinoin-in-mild-to-moderate-papulopustular-rosacea-a-retrospective-review-of-52-patients
#18
Marius Rademaker
BACKGROUND/OBJECTIVES: Rosacea is a chronic inflammatory disorder that affects up to 10% of the population. Standard treatments include topical azelaic acid and metronidazole or systemic tetracyclines. Isotretinoin has generally been restricted to severe disease, often at a dose of 0.5-1.0 mg/kg/day. METHOD: Retrospective review of open-label isotretinoin (initial dose 20 mg/day, with dose adjustments according to response), in patients with mild to moderate papulopustular rosacea...
July 20, 2016: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/27417723/characteristics-of-lipid-fractions-of-larvae-of-the-black-soldier-fly-hermetia-illucens
#19
N A Ushakova, E S Brodskii, A A Kovalenko, A I Bastrakov, A A Kozlova, D S Pavlov
The lipid fraction of larvae of the black soldier fly Hermetia illucens was shown to contain lauric acid (38.43 wt %) and its esters, azelaic and sebacic acids, and azelaic acid dibutyl ester. The dominant compound in the group of identified glycerides was lauric acid monoglyceride (0.70 wt %). Glycerides were also represented by triglycerides and diglycerides of lauric acid. Sterols were represented primarily by phytosterols (over 75%), the major of which was alpha-sitosterol (45%). The identified lipid complex composition is apparently determined by the biological characteristics of the fly Hermetia illucens and ensures antibacterial defence of larvae and stability of lipids at changing ambient temperature...
May 2016: Doklady. Biochemistry and Biophysics
https://www.readbyqxmd.com/read/27414241/dicarboxylic-acids-%C3%AF-oxocarboxylic-acids-%C3%AE-dicarbonyls-wsoc-oc-ec-and-inorganic-ions-in-wintertime-size-segregated-aerosols-from-central-india-sources-and-formation-processes
#20
Dhananjay K Deshmukh, Kimitaka Kawamura, Manas K Deb
The size distributions of aerosols can provide evidences for their sources and formation processes in the atmosphere. Size-segregated aerosols (9-sizes) were collected in urban site (Raipur: 21.2°N and 82.3°E) in central India during winter of 2012-2013. The samples were analyzed for dicarboxylic acids (C2-C12), ω-oxocarboxylic acids (ωC2-ωC9), pyruvic acid and α-dicarbonyls (C2-C3) as well as elemental carbon (EC), organic carbon (OC), water-soluble OC (WSOC) and inorganic ions. Diacids showed a predominance of oxalic acid (C2) followed by succinic and azelaic acid whereas ω-oxoacids exhibited a predominance of glyoxylic acid and glyoxal was more abundant than methylglyoxal in all the sizes...
October 2016: Chemosphere
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