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azelaic acid

Jasmine C Hollinger, Kunal Angra, Rebat M Halder
BACKGROUND: Hyperpigmentation disorders are commonly encountered in dermatology clinics. Botanical and natural ingredients have gained popularity as alternative depigmenting products. OBJECTIVE: We sought to review clinical studies evaluating the use of different natural products in treating hyperpigmentation so clinicians are better equipped to educate their patients. Specific ingredients reviewed include azelaic acid, aloesin, mulberry, licorice extracts, lignin peroxidase, kojic acid, niacinamide, ellagic acid, arbutin, green tea, turmeric, soy, and ascorbic acid...
February 2018: Journal of Clinical and Aesthetic Dermatology
Sean P McGregor, Hossein Alinia, Alyson Snyder, Sara Moradi Tuchayi, Alan Fleischer, Steven R Feldman
Papulopustular rosacea is characterized by papules and pustules in the central facial region. We review the literature surrounding the treatment of papulopustular rosacea. PubMed, EMBASE, and Cochrane (Central) databases searches of articles published from 1980 to 2015 were performed using the MeSH terms or keywords "rosacea" and "clinical trial." Additional searches were performed to include rosacea and each treatment modality used. Topical metronidazole, azelaic acid, ivermectin, and oral doxycycline have the most robust data to support their use...
April 2018: Dermatologic Clinics
Lawrence C Nwabudike
BACKGROUND: Acne vulgaris is a self-limiting disorder of the pilosebaceous unit. The aesthetic aspect of the disorder may provoke depression and diminish the quality of life. A number of agents are used for acne treatment, e.g., retinoids, antibiotics, benzoic acid, azelaic acid, and hormones. These agents have side-effects, sometimes severe ones. CASE REPORTS: Presented are 2 cases of severe acne treated with individualized homeopathic medicines. Both patients were treated using the classical method of homeopathy, i...
2018: Complementary Medicine Research
Nurshafira Khairudin, Mahiran Basri, Hamid Reza Fard Masoumi, Shazwani Samson, Siti Efliza Ashari
Azelaic acid (AzA) and its derivatives have been known to be effective in the treatment of acne and various cutaneous hyperpigmentary disorders. The esterification of azelaic acid with lauryl alcohol (LA) to produce dilaurylazelate using immobilized lipase B from Candida antarctica (Novozym 435) is reported. Response surface methodology was selected to optimize the reaction conditions. A well-fitting quadratic polynomial regression model for the acid conversion was established with regards to several parameters, including reaction time and temperature, enzyme amount, and substrate molar ratios...
February 13, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Yusuke Higashino, Taisuke Okamoto, Kazuki Mori, Takashi Kawasaki, Masahiro Hamada, Noriyuki Nakajima, Akiko Saito
Proanthocyanidins, also known as condensed tannins or oligomeric flavonoids, are found in many edible plants and exhibit interesting biological activities. Herein, we report a new, simple method for the stereoselective synthesis of procyanidin B6, a (+)-catechin-(4-6)-(+)-catechin dimer, by Lewis acid-catalyzed intramolecular condensation. The 5-O-t-butyldimethylsilyl (TBDMS) group of 5,7,3'4'-tetra-O-TBDMS-(+)-catechin was regioselectively removed using trifluoroacetic acid, leading to the "regio-controlled" synthesis of procyanidin B6...
January 18, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Eun-Ji Seo, Young Joo Yeon, Joo-Hyun Seo, Jung-Hoo Lee, Jhoanne P Boñgol, Yuri Oh, Jong Moon Park, Sang-Min Lim, Choul-Gyun Lee, Jin-Byung Park
Oils and fatty acids are important renewable resources provided by nature. Therefore, biotransformation of renewable oils and fatty acids into industrially relevant C9 chemicals was investigated in this study. Olive oil, soybean oil, yeast derived oil, and microalgae fatty acid methyl esters were converted into n-nonanoic acid, 9-hydroxynonanoic acid, and 1,9-nonanedioic acid by a lipase and a recombinant Escherichia coli expressing oleate hydratase, long chain secondary alcohol dehydrogenase, Baeyer-Villiger monooxygenase, long chain primary alcohol dehydrogenase, and aldehyde dehydrogenase...
December 15, 2017: Bioresource Technology
Carmen González-Bosch
Priming by natural compounds is an interesting alternative for sustainable agriculture, which also contributes to explore the molecular mechanisms associated with stress tolerance. Although hosts and stress types eventually determine the mode of action of plant-priming agents, it highlights that many of them act on redox signalling. These include vitamins thiamine, riboflavin and quercetin; organic acids like pipecolic, azelaic and hexanoic; volatile organic compounds such as methyl jasmonate; cell wall components like chitosans and oligogalacturonides; H2O2, etc...
December 22, 2017: Free Radical Biology & Medicine
Aladdin Riad, Chandrakala Aluganti Narasimhulu, Pragney Deme, Sampath Parthasarathy
AIM: In this study, we tested the hypothesis that lipid peroxide-derived dicarboxylic acids, by virtue of their ability bind to calcium, might be involved in atherosclerotic calcification. We determined the ability of azelaic acid (AzA) to promote calcification in human aortic smooth muscle cells (HASMC), identified AzA in human calcified atherosclerotic lesions, and compared its levels with control and non-calcified atherosclerotic lesions. RESULTS: HASMCs efficiently converted 9-oxononanoic acid (ONA), a lipid peroxide derived monocarboxylic aldehyde, to AzA...
December 14, 2017: Antioxidants & Redox Signaling
Yu Jin Park, Eun Sung Jung, Digar Singh, Da Eun Lee, Seunghwan Kim, Young Wook Lee, Jeong-Gu Kim, Choong Hwan Lee
The beech mushrooms have customarily been revered by oriental societies for their nutritional and health benefits. We explored the mass spectrometry (MS) based spatial metabolomic variations between parts (cap and stipe) of two beech mushroom strains (brown and white). The principal component analysis (PCA) revealed their distinct primary (cap and stipe: PC1, 25.5%; strains: PC2, 12.5%) and secondary (cap and stipe: PC1, 10.3%; strains: PC2, 7.6%) metabolite patterns. The caps were rich in amino acids, fatty acids, and N-acetylglucosamine with higher protein and nitrogen contents...
December 2017: Food Research International
Arnaud T Djami-Tchatchou, Efficient N Ncube, Paul A Steenkamp, Ian A Dubery
BACKGROUND: Plants respond to various stress stimuli by activating an enhanced broad-spectrum defensive ability. The development of novel resistance inducers represents an attractive, alternative crop protection strategy. In this regard, hexanoic acid (Hxa, a chemical elicitor) and azelaic acid (Aza, a natural signaling compound) have been proposed as inducers of plant defense, by means of a priming mechanism. Here, we investigated both the mode of action and the complementarity of Aza and Hxa as priming agents in Nicotiana tabacum cells in support of enhanced defense...
November 29, 2017: BMC Plant Biology
P J Wirth, M H Henderson Berg, N Sadick
Approximately 16 million Americans have rosacea, an inflammatory cutaneous disorder with central facial erythema, papules, pustules, telangiectasia, flushing, and swelling being among the more commonly recognized features. Overexpression of cathelicidin peptide LL-37 has been implicated in the pathophysiology of rosacea. Azelaic acid has been found to inhibit the pathologic expression of cathelicidin, as well as the hyperactive protease activity that cleaves cathelicidin into LL-37. Given these findings, a small prospective, open-label, interventional trial was undertaken to assess the effects of azelaic acid 15% gel on inflammatory lesions of papulopustular rosacea in a real-world setting...
November 2017: Skin Therapy Letter
Albert Serra-Compte, Natàlia Corcoll, Belinda Huerta, Sara Rodríguez-Mozaz, Sergi Sabater, Damià Barceló, Diana Álvarez-Muñoz
In many arid and semi-arid systems, biological communities in river ecosystems are submitted to flow interruption and desiccation, as well as to the impact of urban wastewaters. In this work, we studied (using a LC-LTQ-Orbitrap) the metabolomic response of biofilm communities exposed to both hydrological and chemical stressors. Fluvial biofilms were exposed to a mixture of 9 pharmaceuticals at a total concentration of 5000ng/L (mimicking concentrations and compounds found in polluted aquatic environments) and/or to seven days of desiccation, under laboratory conditions...
October 17, 2017: Science of the Total Environment
James Gillis, Kenton Ko, Juliana A Ramsay, Bruce A Ramsay
Greater than 65 % of canola and high oleic soy oil fatty acids is oleic acid, which is readily converted to nonanoic (NA) and azelaic (AzA) acids by ozonolysis. NA is an excellent substrate for medium-chain-length polyhydroxyalkanoate (mcl-PHA) production but AzA has few uses. Pseudomonas citronellolis DSM 50332 and Pseudomonas fluorescens ATCC 17400, both able to produce mcl-PHA from fatty acids and able to grow on AzA as the sole source of carbon and energy were assessed for the accumulation of mcl-PHA from AzA and NA...
October 17, 2017: Canadian Journal of Microbiology
Chunyan Wu, Su Hyeon Hwang, Yaoyao Jia, Joobong Choi, Yeon-Ji Kim, Dahee Choi, Duleepa Pathiraja, In-Geol Choi, Seung-Hoi Koo, Sung-Joon Lee
Olfactory receptors (ORs) are present in tissues outside the olfactory system; however, the function of these receptors remains relatively unknown. Here, we determined that olfactory receptor 544 (Olfr544) is highly expressed in the liver and adipose tissue of mice and regulates cellular energy metabolism and obesity. Azelaic acid (AzA), an Olfr544 ligand, specifically induced PKA-dependent lipolysis in adipocytes and promoted fatty acid oxidation (FAO) and ketogenesis in liver, thus shifting the fuel preference to fats...
November 1, 2017: Journal of Clinical Investigation
Jin-Song Liu, Wei-Na Gao, Juan Zheng, Guo-Kai Wang, Qing-Shan Yang
Eighteen compounds were isolated from the 95% ethanol extract of fresh tubers of Dioscorea bulbifera by column chromatography over silica gel,Sephadex LH-20, and ODS. Their structures were elucidated by spectroscopic data analysis as 6-hydroxy-2,10,10-trimethoxy-anthracen-9-one(1), diosgenin (2), stigmasterol(3), 3, 7-dimethoxy-5, 3', 4'-trihydroxyflavone(4), 2, 7-dihydroxy-3, 4-dimethoxyphenanthrene(5), 3, 7-dihydroxy-2, 4-dimethoxy phenanthrene(6), 2, 7-dihydroxy-4-methoxyphenanthrene (7), 2, 7-dihydroxy-3, 4-dimethoxy-9, 10-dihydroxy phenanthrene(8), azelaic acid (9), 8-epidiosbulbin E acetate (10), 1, 7-bis-(4-hydroxyphenyl)-4E, 6E-heptadien-3-one(11), diosbulbin B(12), pentacosanoic acid 2', 3'-dihydroxypropyl ester(13), 2, 7-dihydroxy-4-methoxy-9, 10-dihydroxy-phenanthrene (14), 1, 7-bis-(4-hydroxyphenyl)-1E, 4E, 6E-heptatrien-3-one (15), 6-ethoxy-1H-pyrimidine-2, 4-dione (16), 3, 5, 4'-trihydroxy-bibenzyl (17), and diosbulbin F (18)...
February 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
Takaomi Yaguchi, Tomohisa Kinami, Tetsuya Ishida, Takaomi Yasuhara, Kosaku Takahashi, Hideyuki Matsuura
It has been reported that treatment with yeast cell wall extract (YCWE) induces PDF1 and PR-1 gene expression; these transcripts are important markers of plant disease resistance, though the detailed signaling mechanisms that induce these defense responses are still unknown. In this report, we found that YCWE treatment triggered rice cell suspension cultures to accumulate phenylalanine (Phe), cis-12-oxo-phytodienoic acid (OPDA), 12-hydroxyjasmonoyle isoleucine (12OHJA-Ile), and azelaic acid (AzA). YCWE treatment also reduced endogenous triacylglycerol (TG) content...
November 2017: Bioscience, Biotechnology, and Biochemistry
Gerald Staedtler, Kaweh Shakery, Jan Endrikat, Richard Nkulikiyinka, Christoph Gerlinger
OBJECTIVE: The aim of this study was to empirically generate a responder definition for the treatment of papulopustular rosacea. METHODS: A total of 8 multicenter clinical studies on patients with papulopustular facial rosacea were analyzed. All patients were treated with azelaic acid and/or comparator treatments. The severity of rosacea was described by the Investigator Global Assessment (IGA) and the number of lesions. Patients with the IGA score of "clear/minimal" were considered as responders, and those staying in the range of IGA "mild to severe" as nonresponders...
2017: Clinical, Cosmetic and Investigational Dermatology
Bodo C Melnik
This review based on translational research predicts that the transcription factor p53 is the key effector of all anti-acne therapies. All-trans retinoic acid (ATRA) and isotretinoin (13-cis retinoic acid) enhance p53 expression. Tetracyclines and macrolides via inhibiting p450 enzymes attenuate ATRA degradation, thereby increase p53. Benzoyl peroxide and hydrogen peroxide elicit oxidative stress, which upregulates p53. Azelaic acid leads to mitochondrial damage associated with increased release of reactive oxygen species inducing p53...
September 19, 2017: Journal of Translational Medicine
Sourav Chakraborty, Subrata Saha, Luís M P Lima, Ulrike Warzok, Sayan Sarkar, Bidyut Akhuli, Mandira Nandi, Somnath Bej, Nayarassery N Adarsh, Christoph A Schalley, Rita Delgado, Pradyut Ghosh
Polyamide-polyamine hybrid macrobicycle L is explored with respect to its ability to bind α,ω-dicarboxylate anions. Potentiometric studies of protonated L with the series of dianions from succinate (suc(2-)) through glutarate (glu(2-)), α-ketoglutarate (kglu(2-)), adipate (adi(2-)), pimelate (pim(2-)), suberate (sub(2-)), to azelate (aze(2-)) have shown adipate preference with association constant value of K = 4900 M(-1) in a H2O/DMSO (50:50 v/v) binary solvent mixture. The binding constant increases from glu(2-) to adi(2-) and then continuously decreases with the length of the anion chain...
September 12, 2017: Journal of Organic Chemistry
Nupur U Patel, Shweta Shukla, Jessica Zaki, Steven R Feldman
Rosacea is a chronic skin condition characterized by transient and persistent erythema of the central face. The symptom of persistent erythema can be particularly frustrating for both patients and physicians as it is difficult to treat. Areas covered: Current treatment options for the treatment of rosacea include metronidazole, azelaic acid, sodium sulfacetamide-sulfur, and brimonidine. Until recently, brimonidine gel was the only option approved specifically for the treatment of facial erythema. However, oxymetazoline hydrochloride 1% cream is a newly FDA approved topical medication for adult rosacea patients...
October 2017: Expert Review of Clinical Pharmacology
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