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https://www.readbyqxmd.com/read/29331221/mechanisms-of-changes-in-functional-mitral-regurgitation-by-preload-alterations
#1
Atsuko Furukawa, Yukio Abe, Kazato Ito, Shingo Hosogi, Katsuhito Yamamoto, Hiroshi Ito
BACKGROUND: This study aimed to investigate the mechanisms of acute changes in functional mitral regurgitation (FMR) by preload alterations. METHODS: Twenty-two consecutive patients with left ventricular ejection fraction <40% and at least mild FMR underwent transthoracic echocardiography. Passive leg lifting and sublingual administration of nitroglycerin were performed to alter preload. Mitral regurgitant volume (MRV) was assessed using the Doppler method. RESULTS: MRV changed in parallel with preload alterations...
January 10, 2018: Journal of Cardiology
https://www.readbyqxmd.com/read/29321212/prognostic-value-of-right-ventricular-dysfunction-in-heart-failure-with-reduced-ejection-fraction-superiority-of-longitudinal-strain-over-tricuspid-annular-plane-systolic-excursion
#2
Erberto Carluccio, Paolo Biagioli, Gianfranco Alunni, Adriano Murrone, Cinzia Zuchi, Stefano Coiro, Clara Riccini, Anna Mengoni, Antonella D'Antonio, Giuseppe Ambrosio
BACKGROUND: In heart failure (HF) with reduced ejection fraction, right ventricular (RV) impairment, as defined by reduced tricuspid annular plane systolic excursion, is a predictor of poor outcome. However, peak longitudinal strain of RV free wall (RVFWS) has been recently proposed as a more accurate and sensitive tool to evaluate RV function. Accordingly, we investigated whether RVFWS could help refine prognosis of patients with HF with reduced ejection fraction in whom tricuspid annular plane systolic excursion is still preserved...
January 2018: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29313818/long-term-mortality-in-patients-with-severe-secondary-mitral-regurgitation-and-normal-left-ventricular-ejection-fraction-interventional-perspective
#3
Amr F Barakat, Mohammad Q Raza, Kinjal Banerjee, Rayji S Tsutsui, Amgad Mentias, Karim Abdur Rehman, Badal Thakkar, Sajjad Gul, Raquib Faruqui, Amar Krishnaswamy, Leonardo L Rodriguez, Richard Grimm, Brian Griffin, Emin Murat Tuzcu, Samir R Kapadia
AIMS: Patients with severe secondary mitral regurgitation (MR) and normal ejection fraction are being excluded from clinical trials evaluating transcatheter mitral devices. We sought to evaluate the long-term mortality with medical management alone in this patient population. METHODS AND RESULTS: We retrospectively evaluated patients diagnosed with ≥3+ mitral MR at our institution over 15 years. Only patients with ejection fraction ≥ 60% were included in the study...
January 9, 2018: EuroIntervention
https://www.readbyqxmd.com/read/29306705/adverse-impact-of-diabetes-mellitus-on-left-ventricular-remodelling-in-patients-with-chronic-primary-mitral-regurgitation
#4
Laura Ernande, Jonathan Beaudoin, Victoria Piro, Souhila Meziani, Marielle Scherrer-Crosbie
BACKGROUND: Diabetes mellitus (DM) has an impact on left ventricular (LV) geometry and function, and is associated with worsening of pressure-overload LV remodelling; however, its impact on volume-overload LV remodelling is unknown. AIM: The objective of the study was to examine the association between DM and LV remodelling in patients with chronic mitral regurgitation (MR) caused by mitral valve prolapse. METHODS: During a median follow-up of 3...
January 3, 2018: Archives of Cardiovascular Diseases
https://www.readbyqxmd.com/read/29302944/restrictive-mitral-annuloplasty-with-or-without-papillary-muscle-approximation-for-functional-mitral-regurgitation
#5
Yusuke Misumi, Takafumi Masai, Koichi Toda, Teruya Nakamura, Shigeru Miyagawa, Yasushi Yoshikawa, Satsuki Fukushima, Shunsuke Saito, Keitaro Domae, Satoshi Kainuma, Takayoshi Ueno, Toru Kuratani, Takashi Daimon, Yoshiki Sawa
BACKGROUND: The impact of adding papillary muscle approximation (PMA) to restrictive mitral annuloplasty (RMA) on postoperative left ventricular (LV) function is unknown. Changes in LV function parameters and clinical outcome were evaluated following RMA with and without PMA in patients with clinically relevant functional mitral regurgitation (FMR). METHODS: A total of 176 patients with advanced cardiomyopathy underwent RMA either with (n = 59) or without (n = 117) PMA...
July 2017: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/29302943/left-heart-ejection-fraction-as-a-load-independent-parameter-for-patients-with-mitral-regurgitation
#6
Hai-Yan Chen, Jun Li, Chun-Sheng Wang, Cui-Zhen Pan, Xian-Hong Shu
BACKGROUND: The functions of the left ventricle and left atrium are closely associated with the outcomes of surgically treated patients with severe mitral regurgitation (MR). However, both parameters were overestimated in the presence of MR. The present study integrated the left atrium and left ventricle as the left heart (LH) to eliminate the influence of MR within the integrated structure. The study aim was to explore whether the emptying fraction of the LH is a load-independent parameter for patients with MR...
July 2017: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/29302935/outcomes-of-surgery-for-severe-aortic-regurgitation-with-systolic-left-ventricular-dysfunction
#7
Piergiorgio Bruno, Federico Cammertoni, Raphael Rosenhek, Andrea Mazza, Marialisa Nesta, Francesco Burzotta, Domenico D'Amario, Massimo Massetti
BACKGROUND: Management of patients with aortic regurgitation (AR) and severe impairment of left ventricular (LV) function characterized by an ejection fraction (EF) ≤35% is challenging. Conflicting results regarding perioperative and long-term survival of these patients have been reported. The study aim was to compare in-hospital outcomes and long-term survival of patients with AR and severe LV dysfunction versus moderate dysfunction (35% <EF <50%) versus preserved LV function (EF ≥50%)...
July 2017: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/29302462/valve-sparing-aortic-root-replacement-midterm-outcomes-and-quality-of-life
#8
Abdel-Kémal Bori Bata, Nicolas D'Ostrevy, Bruno Pereira, Etienne Geoffroy, Nicolas Dauphin, Vedat Eljezi, Kasra Azarnoush, Lucie Ulman, Lionel Camilleri
Background: This study evaluated the midterm outcomes, the valve related events and quality of life of patients treated by valve-sparing aortic root replacement (VSRR). Methods: From January 2003 to December 2014, 88 consecutive patients diagnosed with an aortic root aneurysm or ascending aortic aneurysms underwent VSRR surgery. The mean age was 55±14 (range 19-77) years. A total of 84% of the patients were male; 89% were in New York Heart Association functional class I or II, 55% had aortic regurgitation (AR) grade III or IV...
December 2017: Cardiovascular Diagnosis and Therapy
https://www.readbyqxmd.com/read/29297708/determinants-of-elevated-carbohydrate-antigen-125-in-patients-with-severe-symptomatic-aortic-valve-stenosis-referred-for-transcatheter-aortic-valve-implantation
#9
Tobias Rheude, Costanza Pellegrini, Wibke Reinhard, Teresa Trenkwalder, Wolfgang Koenig, N Patrick Mayr, Michael Joner, Julio Núñez, Stefan Holdenrieder, Heribert Schunkert, Adnan Kastrati, Christian Hengstenberg, Oliver Husser
PURPOSE: Elevated carbohydrate antigen 125 (CA125) predicts adverse outcome after transcatheter aortic valve implantation (TAVI). While known underlying pathophysiological mechanisms of elevated CA125 include serosal effusions and inflammatory stimuli, clinical determinants associated with elevated CA125 in patients referred for TAVI remain unknown. Therefore, we investigated clinical, laboratory and echocardiographic determinants of elevated CA125 in patients with severe aortic valve stenosis referred for TAVI...
January 3, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29291344/diagnosis-and-management-of-ischemic-mitral-regurgitation-evidence-based-clinical-decision-making-at-the-point-of-care
#10
Ajay Kumar Jha, Vishwas Malik
Anatomical, functional, and pathophysiologic mechanisms of ischemic mitral regurgitation (IMR) are markedly different from the primary mitral regurgitation. The older and ubiquitous cutoff of EROA (effective regurgitant orifice area) and Rvol (regurgitant volume) for IMR has been reinstated in the new guideline after a brief hiatus. There had always been a lack of good-quality evidence for its introduction for guiding IMR severity in the previous guideline, and we still do not have quality evidences that could justify its reintroduction...
December 1, 2017: Seminars in Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29282097/the-correlation-between-the-coaptation%C3%A2-height-of-mitral-valve-and-mitral-regurgitation-after-mitral-valve-repair
#11
Dan Wei, Jie Han, Haibo Zhang, Yan Li, Chunlei Xu, Xu Meng
BACKGROUND: To investigate the association between the coaptation height of mitral valve and mitral regurgitation after mitral valve repair. METHODS: From Sep 2014 to Jun 2015, 20 patients underwent mitral valve valvuloplasty for mitral regurgitation were included. Ring annuloplasty was performed in all cases. Mitral valve short-axis dimension (MVd), coaptation height (CH), Left ventricular ejection fraction (LVEF) were measured by the transesophageal echocardiography before the operation in operation room and 3 months and 12 months after the operation by the transthoracic echocardiography...
December 28, 2017: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29245279/mitral-regurgitation-after-anthracycline-based-chemotherapy-in-an-adult-patient-with-breast-cancer-a-case-report
#12
Xiaoyan Liu, Yanlin Zhu, Xue Lin, Ligang Fang, Xiaowei Yan
RATIONALE: Anthracyclines cardiotoxicity characterized by dilated myocardiopathy has been well described in the literature. However, anthracyclines-induced valvular diseases have been seldom reported. PATIENT CONCERNS: In this study, we present the case of a 62-year-old Chinese female patient with breast cancer developing severe mitral regurgitation after anthracycline exposure. DIAGNOSES: The patient was diagnosed with mitral regurgitation with preserved left ventricular ejection fraction and normal cardiac chamber dimensions in the sixth month after the last course of anthracycline-containing chemotherapy...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29225904/late-stage-left-ventricular-dysfunction-in-adult-survivors-of-tetralogy-of-fallot-repair-in-childhood
#13
Abdel Anabtawi, Judith Mondragon, Diane Dodendorf, Warren K Laskey
Objective: Left ventricular systolic dysfunction (LVSD) in adult survivors of tetralogy of Fallot (TOF) repair in childhood has been observed, although the relationship with long-term outcome remains inadequately described. Methods: A cohort of 44 consecutive adult patients with TOF repair in childhood were followed prospectively from January 2001 through June 2016. LVSD was defined as an echocardiographically derived left ventricular (LV) ejection fraction <0...
2017: Open Heart
https://www.readbyqxmd.com/read/29222864/effects-of-cardiac-resynchronization-therapy-after-inferior-myocardial-infarction-on-secondary-mitral-regurgitation-and-mitral-valve-geometry
#14
Christos G Mihos, Evin Yucel, Romain Capoulade, Mary P Orencole, Gaurav A Upadhyay, Orlando Santana, Jagmeet P Singh, Michael H Picard
BACKGROUND: The effects of cardiac resynchronization therapy (CRT) on secondary mitral regurgitation (MR), and mitral valve (MV) and left ventricular (LV) geometry, in patients with prior inferior myocardial infarction is not clearly defined. We assessed these outcomes utilizing 2-dimensional echocardiography, and analyzed echocardiographic geometric variables that may correlate with follow-up MR severity. METHODS: Between 2009 and 2012, 229 CRT were implanted. Twenty-two had prior inferior myocardial infarction, ≥ mild MR at baseline, and serial echocardiography...
December 9, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/29218014/acute-effects-of-positive-airway-pressure-on-functional-mitral-regurgitation-in-patients-with-systolic-heart-failure
#15
Takao Kato, Takatoshi Kasai, Shoichiro Yatsu, Azusa Murata, Hiroki Matsumoto, Shoko Suda, Masaru Hiki, Nanako Shiroshita, Mitsue Kato, Fusae Kawana, Sakiko Miyazaki, Hiroyuki Daida
Background: Acute effects of positive airway pressure (PAP) [including continuous PAP (CPAP) and adaptive servo-ventilation, an advanced form of bi-level PAP] on functional mitral regurgitation (fMR) in patients with heart failure (HF) with left ventricular (LV) systolic dysfunction remain unclear. Thus, whether PAP therapy reduces fMR in such patients with HF was investigated. Methods and Results: Twenty patients with HF and LV systolic dysfunction defined as LV ejection fraction (LVEF) <50% (14 men; mean LVEF, 35...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29208632/right-ventricular-exercise-contractile-reserve-and-outcomes-after-early-surgery-for-primary-mitral-regurgitation
#16
Emilie Vitel, Elena Galli, Christophe Leclercq, Maxime Fournet, Christian Bosseau, Hervé Corbineau, Guillame Bouzille, Erwan Donal
OBJECTIVE: To assess if the lack of development of right ventricular (RV) contractile reserve during exercise echocardiography (ex-echo) might be a predictor of postoperative major adverse cardiovascular events (MACEs) in patients with primary mitral regurgitation (pMR) undergoing early surgery. METHODS: Comprehensive resting and ex-echo were performed in 142 asymptomatic patients (58±21 years, 68% men, New York Heart Association functional class ≤2) with isolated severe pMR and preserved left ventricular (LV) function (LV ejection >60%, LV end-systolic diameter <45 mm) undergoing mitral valve replacement (n=20) or repair...
December 5, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29206322/4d-flow-mri-cardiac-function-and-t1-mapping-association-of-valve-mediated-changes-in-aortic-hemodynamics-with-left-ventricular-remodeling
#17
Julia Geiger, Amir A Rahsepar, Kenichiro Suwa, Alex Powell, Ahmadreza Ghasemiesfe, Alex J Barker, Jeremy D Collins, James C Carr, Michael Markl
BACKGROUND: Patients with bicuspid aortic valve (BAV) show altered hemodynamics in the ascending aorta that can be assessed by 4D flow MRI. PURPOSE: Comprehensive cardiac MRI was applied to test the hypothesis that BAV-mediated changes in aortic hemodynamics (wall shear stress [WSS] and velocity) are associated with parameters of left ventricular (LV) remodeling. STUDY TYPE: Retrospective data analysis. POPULATION: Forty-nine BAV patients (mean age = 50...
December 5, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29193376/evaluation-of-left-ventricular-reverse-remodeling-in-patients-with-severe-aortic-regurgitation-undergoing-aortic-valve-replacement-comparison-between-diameters-and-volumes
#18
Géraldine Ong, Bjorn Redfors, Aaron Crowley, Husam Abdel-Qadir, Alana Harrington, Yangbo Liu, Myriam Lafrenière-Roula, Howard Leong-Poi, Mark D Peterson, Kim A Connelly
BACKGROUND: In patients with severe aortic regurgitation (AR), the left ventricular ejection fraction (LVEF) and left ventricle (LV) size are crucial for determining clinical prognosis and timing of valve intervention. In clinical practice, LV internal diameters obtained at end-diastole are used to assess the degree of LV dilatation. Whether quantification of LV volumes would provide more robust information as compared to LV linear dimensions is unknown. METHODS: We retrospectively analyzed preoperative and postoperative transthoracic echocardiograms of patients who underwent aortic valve replacement (AVR) for severe AR...
November 28, 2017: Echocardiography
https://www.readbyqxmd.com/read/29191732/quantification-of-aortic-valve-regurgitation-by-pulsed-doppler-examination-of-the-left-subclavian-artery-velocity-contour-a-validation-study-with-cardiovascular-magnetic-resonance-imaging
#19
Ricardo A Spampinato, Cosima Jahnke, Ingo Paetsch, Sebastian Hilbert, Franziska Busch, Valerie Schloma, Yaroslava Dmitrieva, Fernanda Bonamigo Thome, Susanne Löbe, Elfriede Strotdrees, Gerhard Hindricks, Friedrich-Wilhelm Mohr, Michael A Borger
BACKGROUND: Reflux of the aortic regurgitation (AR) causes an increased diastolic reverse flow in the aorta and its branching vessels. We aimed to evaluate the feasibility and accuracy of Doppler measurements in the left subclavian artery (LSA) for quantification of AR in a cardiovascular magnetic resonance imaging (CMR) validation study. METHODS: Systolic and diastolic flow profiles of the LSA (subclavicular approach) were evaluated prospectively by use of pulsed wave Doppler in 59 patients (55...
November 28, 2017: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/29191730/clinical-outcome-of-isolated-tricuspid-regurgitation-in-patients-with-preserved-left%C3%A2-ventricular-ejection-fraction-and-pulmonary%C3%A2-hypertension
#20
Nir Bar, Lorin Arie Schwartz, Simon Biner, Galit Aviram, Meirav Ingbir, Ido Nachmany, Gilad Margolis, Ben Sadeh, Rami Barashi, Gad Keren, Yan Topilsky
BACKGROUND: The outcome of tricuspid regurgitation (TR) remains unclear because of heterogeneity of etiology and the contradictory results of outcome studies. The aim of this study was to evaluate the clinical outcomes of TR in patients with pulmonary hypertension (PH) and normal left systolic function, stratified to patients with post- or precapillary PH. METHODS: In patients with no left valvar disease (isolated) functional TR, preserved left systolic function (ejection fraction ≥ 50%), and PH (systolic pulmonary pressure > 50 mm Hg), TR was assessed both qualitatively (grade) and semiquantitatively using the vena contracta method, and retrospective analysis of long-term outcomes was conducted...
November 28, 2017: Journal of the American Society of Echocardiography
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