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https://www.readbyqxmd.com/read/28945022/-progress-of-gene-editing-technologies-and-prospect-in-traditional-chinese-medicine
#1
REVIEW
Yan-Yan Ma, Jing-Zhe Li, Er-Ning Gao, Dan Qian, Ju-Ying Zhong, Chang-Zhen Liu
Gene editing is a kind of technologies that makes precise modification to the genome. It can be used to knock out/in and replace the specific DNA fragment, and make accurate gene editing on the genome level. The essence of the technique is the DNA sequence change with use of non homologous end link repair and homologous recombination repair, combined with specific DNA target recognition and endonuclease.This technology has wide range of development prospects and high application value in terms of scientific research, agriculture, medical treatment and other fields...
January 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28944987/the-international-society-for-bipolar-disorders-task-force-report-on-pediatric-bipolar-disorder-knowledge-to-date-and-directions-for-future-research
#2
REVIEW
Benjamin I Goldstein, Boris Birmaher, Gabrielle A Carlson, Melissa P DelBello, Robert L Findling, Mary Fristad, Robert A Kowatch, David J Miklowitz, Fabiano G Nery, Guillermo Perez-Algorta, Anna Van Meter, Cristian P Zeni, Christoph U Correll, Hyo-Won Kim, Janet Wozniak, Kiki D Chang, Manon Hillegers, Eric A Youngstrom
OBJECTIVES: Over the past two decades, there has been tremendous growth in research regarding bipolar disorder (BD) among children and adolescents (ie, pediatric BD [PBD]). The primary purpose of this article is to distill the extant literature, dispel myths or exaggerated assertions in the field, and disseminate clinically relevant findings. METHODS: An international group of experts completed a selective review of the literature, emphasizing areas of consensus, identifying limitations and gaps in the literature, and highlighting future directions to mitigate these gaps...
September 25, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28944946/nerve-grafting-vs-common-infraclavicular-intraplexal-nerve-transfer-in-elbow-flexion-restoration
#3
Vesna SİMİć, Andrija SAVİć, Milan JOVANOVİć, Filip VİTOšEVİć, Branko ĐUROVİć, Čedomir MİLOšEVİć, Novak LAKİćEVİć, Miroslav SAMARDžİć, Lukas RASULİć
AIM: The aim of this study is to compare the results of nerve grafting vs. common infraclavicular intraplexal nerve transfer in elbow flexion restoration. MATERIAL AND METHODS: The study included 39 patients with upper brachial plexus palsy who were operated using common intraplexal nerve transfer (Oberlin procedure) and the thoracodorsal and medial pectoral nerve transfer to the musculocutaneous nerve or grafting of C5 to the musculocutneous nerve, for elbow flexion restoration...
July 12, 2017: Turkish Neurosurgery
https://www.readbyqxmd.com/read/28944628/-understanding-the-use-of-mechanical-restraints-in-psychiatry-160-phenomenological-study-of-nurses-8217-lived-experience
#4
Pascale Corneau, Jean Daniel Jacob, Dave Holmes, Desire Rioux
The use of mechanical restraints in psychiatric settings is currently the subject of ethical controversy. However, both patients' and nurses' voices are absent in the debate over this controversial intervention. The objective of this qualitative study was to examine the experience of psychiatric nurses using mechanical restraints. Twentyone nurses working on either the acute psychiatric inpatient unit and/or the emergency psychiatric unit of a university affiliated Canadian hospital participated in semi-structured interviews, which were then transcribed, coded and analyzed using the interpretative phenomenological analysis (IPA) method...
April 19, 2017: Recherche en Soins Infirmiers
https://www.readbyqxmd.com/read/28944619/comparative-study-of-new-autologous-material-bone-cartilage-composite-graft-bccg-for-ossiculoplasty-with-polycel-%C3%A2-and-titanium
#5
Ji Sun Kong, Chang Yeong Jeong, Myung Joo Shim, Woo Jin Kim, Sang Won Yeo, Shi Nae Park
OBJECTIVE: Ossiculoplasty is a surgical procedure that recreates sound transmission of the middle ear in conductive hearing loss. Various materials have been used for ossicular reconstruction, but the most ideal material for ossiculoplasty remains controversial. The purpose of this study is to introduce a novel method of autologous ossiculoplasty, bone-cartilage composite graft (BCCG), and to compare its surgical results with different types of ossiculoplastic prostheses. STUDY DESIGN: A retrospective study was performed in a tertiary referral center...
September 25, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28944443/the-relationship-between-self-reported-borderline-personality-features-and-prospective-illness-course-in-bipolar-disorder
#6
Georg Riemann, Nadine Weisscher, Robert M Post, Lori Altshuler, Susan McElroy, Marc A Frye, Paul E Keck, Gabriele S Leverich, Trisha Suppes, Heinz Grunze, Willem A Nolen, Ralph W Kupka
BACKGROUND: Although bipolar disorder (BD) and borderline personality disorder (BPD) share clinical characteristics and frequently co-occur, their interrelationship is controversial. Especially, the differentiation of rapid cycling BD and BPD can be troublesome. This study investigates the relationship between borderline personality features (BPF) and prospective illness course in patients with BD, and explores the effects of current mood state on self-reported BPF profiles. METHODS: The study included 375 patients who participated in the former Stanley Foundation Bipolar Network...
September 25, 2017: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/28944332/the-whitehead-operation-procedure-is-it-a-useful-technique
#7
Kenan Erzurumlu, Kağan Karabulut, Gökhan Selçuk Özbalcı, İsmail Alper Tarım, Gökhan Lap, Bülent Güngör
OBJECTIVE: Hemorrhoidal disease is a very common entity in the general population; however, the therapeutic approaches to hemorrhoids remain controversial. The choice of treatment method depends on the grade of the hemorrhoid as well as the experience of the surgeon. The Whitehead hemorrhoidectomy procedure is often applied for grade IV hemorrhoids. MATERIAL AND METHODS: We studied 49 patients who underwent surgery between December 1982 and January 2013. The indications for the Whitehead procedure in all patients were grade IV hemorrhoidal disease...
2017: Turk J Surg
https://www.readbyqxmd.com/read/28944288/the-wisdom-study-breaking-the-deadlock-in-the-breast-cancer-screening-debate
#8
REVIEW
Laura J Esserman
There are few medical issues that have generated as much controversy as screening for breast cancer. In science, controversy often stimulates innovation; however, the intensely divisive debate over mammographic screening has had the opposite effect and has stifled progress. The same two questions-whether it is better to screen annually or bi-annually, and whether women are best served by beginning screening at 40 or some later age-have been debated for 20 years, based on data generated three to four decades ago...
2017: NPJ Breast Cancer
https://www.readbyqxmd.com/read/28944252/anconeus-muscle-pedicle-bone-graft-with-periosteal-coverage-for-osteochondritis-dissecans-of-the-humeral-capitellum
#9
Kozo Shimada, Ko Temporin, Keiichiro Oura, Hiroyuki Tanaka, Ryosuke Noguchi
BACKGROUND: Treatment of advanced osteochondritis dissecans (OCD) of the capitellum is controversial, especially in moderate-sized lesions. PURPOSE: To establish a treatment algorithm for capitellum OCD, we tried to determine the utility of and problems associated with anconeus muscle-pedicle bone graft with periosteal coverage (ABGP) for the treatment of moderate-sized articular OCD defects of the capitellum. STUDY DESIGN: Case series; Level of evidence, 4...
September 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28944249/return-to-play-following-shoulder-stabilization-a-systematic-review-and-meta-analysis
#10
REVIEW
Marc N Ialenti, Jeffrey D Mulvihill, Max Feinstein, Alan L Zhang, Brian T Feeley
BACKGROUND: Anterior shoulder instability can be a disabling condition for the young athlete; however, the best surgical treatment remains controversial. Traditionally, anterior shoulder instability was treated with open stabilization. More recently, arthroscopic repair of the Bankart injury with suture anchor fixation has become an accepted technique. HYPOTHESIS: No systematic reviews have compared the rate of return to play following arthroscopic Bankart repair with suture anchor fixation with the Bristow-Latarjet procedure and open stabilization...
September 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28944147/sigmoid-volvulus-in-young-patients-%C3%A4-new-twist-on-an-old-diagnosis
#11
Moaziz Sarfaraz, Syeda Rana Hasan, Shahid Lateef
According to the literature, sigmoid volvulus typically develops in patients of an older age with co-morbidities such as a psychiatric illness or a bed-bound chronic illness. Recent reports suggest that it should also be considered in young individuals without any preceding medical history. Abdominal roentgenography is a cheap and effective diagnostic modality that can avoid a delay in diagnosis. The treatment of colonic volvulus remains controversial and relies upon the procedure selected and the most appropriate therapeutic approach in terms of the clinical status of the patient, the location of the problem, the suspected existence or identification of peritonitis, bowel viability, and the expertise of the surgical team...
August 2017: Intractable & Rare Diseases Research
https://www.readbyqxmd.com/read/28943908/expression-of-chicken-ovalbumin-upstream-promoter-transcription-factor-ii-and-liver-x-receptor-as-prognostic-indicators-for-human-colorectal-cancer
#12
Seong-Hoon Yun, Min-Gyoung Park, Yu-Mi Kim, Mee-Sook Roh, Joo-In Park
Cholesterol increases the risk of colorectal cancer. Liver X receptor (LXR), retinoid X receptor (RXR)α and sterol regulatory element binding protein (SREBP)-1c are transcriptional regulators of lipid metabolism. Chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) serves an essential role in angiogenesis and development, but its role in cancer is controversial. The expression of COUP-TFII, LXR, RXRα and SREBP-1c in colorectal cancer, as well as their association with clinicopathologic features, was assessed, and their utility as prognostic indicators in colorectal cancer evaluated...
October 2017: Oncology Letters
https://www.readbyqxmd.com/read/28943877/%C3%AE-catenin-directs-nuclear-factor-%C3%AE%C2%BAb-p65-output-via-creb-binding-protein-p300-in-human-airway-smooth-muscle
#13
Tim Koopmans, Roos Eilers, Mark Menzen, Andrew Halayko, Reinoud Gosens
β-Catenin is a multifunctional protein that apart from its role in proliferative and differentiation events, also acts upon inflammatory processes, mainly via interaction with nuclear factor-κB (NF-κB). However, there is still controversy as to whether β-catenin facilitates or represses NF-κB output. Insights into the molecular mechanisms underlying the interaction between β-catenin and NF-κB have highlighted the cofactors CREB-binding protein (CBP) and p300 as important candidates. Here, we hypothesized that the interaction of β-catenin with CBP/p300 directs NF-κB output...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28943589/should-the-selective-arterial-secretagogue-injection-test-for-insulinoma-localization-be-evaluated-at-60-or-120-seconds
#14
Keijiro Ueda, Tetsuhide Ito, Ken Kawabe, Lingaku Lee, Takashi Fujiyama, Yuichi Tachibana, Masami Miki, Kohei Yasunaga, Takehiro Takaoka, Akihiro Nishie, Yoshiki Asayama, Robert T Jensen, Yoshihiro Ogawa
Objective The selective arterial secretagogue injection (SASI) test is considered indispensable for the accurate localization of insulinoma. However, the optimum timing of the post-injection evaluation is controversial, as some studies recommend 60 seconds (SASI [(60 sec]) while others support 120 seconds (SASI [120 sec]). The aim of this study was to determine the optimum timing for the SASI test evaluation for insulinoma localization. Methods Thirteen patients with surgically proven insulinoma were studied retrospectively...
September 25, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28943411/two-cortical-deficits-underlie-amblyopia-a-multi-focal-fmri-analysis
#15
REVIEW
Reza Farivar, Jiawei Zhou, Yufeng Huang, Lixia Feng, Yifeng Zhou, Robert F Hess
Amblyopia is a relatively common (incidence 3%) developmental disorder in which there is loss of vision as a consequence of a disruption to normal visual development. Although the deficit is monocular and known to be of cortical origin, the nature of the processing deficit is controversial. Human behavioral studies have identified two main deficits-a loss of contrast sensitivity and perceived spatial distortions. Here we use a multi-focal fMRI approach to ascertain, in a group of anisometropic amblyopes, whether these two deficits have a single common cause or whether they are the result of two underlying independent cortical disorders...
September 21, 2017: NeuroImage
https://www.readbyqxmd.com/read/28943339/%C3%AE-catenin-coordinates-with-jup-and-the-tcf1-gata6-axis-to-regulate-human-embryonic-stem-cell-fate
#16
Hongwei Sun, Xiaohu Wang, Kuisheng Liu, Mengmeng Guo, Yan Zhang, Qi-Long Ying, Shoudong Ye
β-catenin-mediated signaling has been extensively studied in regard to its role in the regulation of human embryonic stem cells (hESCs). However, the results are controversial and the mechanism by which β-catenin regulates the hESC fate remains unclear. Here, we report that β-catenin and γ-catenin are functionally redundant in mediating hESC adhesion and are required for embryoid body formation, but both genes are dispensable for hESC maintenance, as the undifferentiated state of β-catenin and γ-catenin double deficient hESCs can be maintained...
September 21, 2017: Developmental Biology
https://www.readbyqxmd.com/read/28943204/considerations-for-antibiotic-prophylaxis-in-head-and-neck-cancer-surgery
#17
Michael P Veve, Susan L Davis, Amy M Williams, John E McKinnon, Tamer A Ghanem
Peri/post-operative antibiotic prophylaxis (POABP) has become standard practice for preventing surgical site infections (SSI) in head and neck cancer patients undergoing microvascular reconstruction, but few data exist on optimal POABP regimens. Current surgical prophylaxis guideline recommendations fail to account for the complexity of microvascular reconstruction relative to other head and neck procedures, specifically regarding wound classification and antibiotic duration. Selection of POABP spectrum is also controversial, and must balance the choice between too narrow, risking subsequent infection, or too broad, and possible unwanted effects (e...
September 21, 2017: Oral Oncology
https://www.readbyqxmd.com/read/28943123/prognostic-significance-of-spontaneous-shockable-rhythm-conversion-in-adult-out-of-hospital-cardiac-arrest-patients-with-initial-non-shockable-heart-rhythms-a-systematic-review-and-meta-analysis
#18
Shengyuan Luo, Yongshu Zhang, Wanwan Zhang, Ruiying Zheng, Jun Tao, Yan Xiong
BACKGROUND: There remains controversy over the prognostic significance of spontaneous shockable rhythm conversion in out-of-hospital cardiac arrest (OHCA) patients with initial non-shockable heart rhythms (pulseless electrical activity [PEA] or asystole). The aim of this study was to examine the association of shockable rhythm conversion with multiple OHCA outcomes, and to explore effect modifiers. METHODS: A dual-reviewer search was conducted in PubMed and EMBASE databases in March 2017...
September 21, 2017: Resuscitation
https://www.readbyqxmd.com/read/28943111/relationship-between-higher-serum-selenium-level-and-adverse-blood-lipid-profile
#19
Wen Ju, Mei Ji, Xia Li, Zhe Li, Guanrui Wu, Xiaofeng Fu, Xiaomei Yang, Xibao Gao
BACKGROUND: As the key component of glutathione peroxidase with unique antioxidant properties, selenium has been considered to play an important part on lipid metabolism. However, the associations of serum selenium concentrations with lipid concentrations and dyslipidemia are still controversial. METHODS: We analyzed cross-sectional data including serum selenium levels, lipid concentrations and other related indexes of 8198 rural Chinese. Serum selenium was measured by inductively coupled plasma mass spectrometry, and total cholesterol (TC), triglyceride (TG), high density lipoprotein-cholesterol (HDL-c) and low density lipoprotein-cholesterol (LDL-c) of serum were measured with kits...
September 4, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28943096/the-incidence-rate-of-cancer-in-patients-with-schizophrenia-a-meta-analysis-of-cohort-studies
#20
REVIEW
Hailong Li, Jiasi Li, Xiya Yu, Huiwen Zheng, Xu Sun, Yue Lu, Yanbo Zhang, Chunbo Li, Xiaoying Bi
BACKGROUND: Numerous studies report that cancer prevalence in patients with schizophrenia might be different from the general population, but findings remain controversial. AIM: Our updated meta-analysis of cohort studies aims to analyze the data from cohort studies concerning the incidence risk of overall cancer and some site-specific cancers in patients with schizophrenia. METHOD: We performed a systemic search through electronic databases...
September 21, 2017: Schizophrenia Research
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