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Very low carbohydrate diet

Francisco Navarro, Eduardo Forján, María Vázquez, Zaida Montero, Elisabeth Bermejo, Miguel Ángel Castaño, Alberto Toimil, Enrique Chagüaceda, Miguel Ángel García-Sevillano, Marisa Sánchez, María José Domínguez, Rosario Pásaro, Inés Garbayo, Carlos Vílchez, José María Vega
BACKGROUND: Edible microalgae are marine or fresh water mesophilic species. Although the harvesting of microalgae offers an abundance of opportunities to the food and pharmaceutical industries, the possibility to use extremophilic microalgae as a food source for animals is not well-documented. OBJECTIVE: We studied the effects of dietary supplementation of a powdered form of the acidophilic microalga Coccomyxa onubensis on growth and health parameters of laboratory rats...
2016: Food & Nutrition Research
Alessandra Lodi, Bettina Karsten, Gerardo Bosco, Manuel Gómez-López, Paula Paraguassú Brandão, Antonino Bianco, Antonio Paoli
: The aim of this study was to analyze the effects on blood sugar concentrations through the calculation of the glycemic score (GS) of 10 different high-protein low-carbohydrates (CHOs) proprietary foods that are commonly used as meals during very low-CHO ketogenic diets or during low-CHO diets. Fourteen healthy females were tested for their glycemic response curve elicited by 1000 kJ of glucose three times within a 3-week period (one test each week) compared with one of 10 test foods once on separate days twice a week...
October 18, 2016: Journal of Medicinal Food
Danxia Yu, Xianglan Zhang, Xiao-Ou Shu, Hui Cai, Honglan Li, Ding Ding, Zhen Hong, Yong-Bing Xiang, Yu-Tang Gao, Wei Zheng, Gong Yang
BACKGROUND: Epidemiologic evidence on dietary carbohydrates and stroke risk remains controversial. Very few prospective cohort studies have been conducted in Asian populations, who usually consume a high-carbohydrate diet and have a high burden of stroke. OBJECTIVE: We examined dietary glycemic index (GI), glycemic load (GL), and intakes of refined and total carbohydrates in relation to risks of total, ischemic, and hemorrhagic stroke and stroke mortality. DESIGN: This study included 64,328 Chinese women, aged 40-70 y, with no history of cardiovascular disease, diabetes, or cancer...
October 12, 2016: American Journal of Clinical Nutrition
Nadia Musco, Serena Calabro, Raffaella Tudisco, Micaela Grossi, Laura Addi, Giuseppe Moniello, Pietro Lombardi, Monica Isabella Cutrignelli
In the paper the short- and long-term glycaemic response after 4 diet programmes was evaluated. Each diet programme was alternatively administered to 6 healthy cats for 30 days. At the end of each period cats were weighed and underwent blood sampling for glucose and fructosamine determination. Glycaemia was measured every 2 hours for 24 hours using an automated glucometer. Very high protein level and low starch (VHP/LS) and high protein and moderate starch level (HP/LS) diets showed glucose (Mean and Peak) and fructosamine values signi cantly lower compared to the moderate protein and high starch diets (MP/HS)...
August 3, 2016: Veterinaria Italiana
Tomasz Klupa, Michał Możdżan, Janina Kokoszka-Paszkot, Magdalena Kubik, Małgorzata Masierek, Margerita Czerwińska, Maciej T Małecki
There is no doubt that behavioral intervention is crucial for type 2 diabetes mellitus (T2DM) prevention and management. We aimed to estimate dietary habits and diet-oriented knowledge as well as the level of physical activity in 2500 insulin-treated Polish type 2 diabetes mellitus (T2DM) patients (55.4% women). The mean age of the study participants was 64.9 ± 9.3 years, mean BMI was 31.4 kg/m(2) ± 4.5, mean diabetes duration was 12.4 ± 6.9 years, and mean baseline HbA1c was 8.5%  ± 1.2. At the study onset, all the patients completed a questionnaire concerning health-oriented behavior...
2016: International Journal of Endocrinology
Peter L Zock, Wendy A M Blom, Joyce A Nettleton, Gerard Hornstra
Dietary fats have important effects on the risk of cardiovascular disease (CVD). Abundant evidence shows that partial replacement of saturated fatty acids (SAFA) with unsaturated fatty acids improves the blood lipid and lipoprotein profile and reduces the risk of coronary heart disease (CHD). Low-fat diets high in refined carbohydrates and sugar are not effective. Very long-chain polyunsaturated n-3 or omega-3 fatty acids (n-3 VLCPUFA) present in fish have multiple beneficial metabolic effects, and regular intake of fatty fish is associated with lower risks of fatal CHD and stroke...
November 2016: Current Cardiology Reports
Rui Fan, Meihong Xu, Junbo Wang, Zhaofeng Zhang, Qihe Chen, Ye Li, Jiaojiao Gu, Xiaxia Cai, Qianying Guo, Lei Bao, Yong Li
Diabetes mellitus is very common in elderly Chinese individuals. Although nutritional intervention can provide a balanced diet, the sustaining effect on at-home dietary behavior and long-term plasma glucose control is not clear. Consequently, we conducted a long-term survey following one month of experiential nutritional intervention combined with health education. Based on the Dietary Guidelines for a Chinese Resident, we found that the food items met the recommended values, the percentages of energy provided from fat, protein, and carbohydrate were more reasonable after one year...
2016: Nutrients
A Goday, D Bellido, I Sajoux, A B Crujeiras, B Burguera, P P García-Luna, A Oleaga, B Moreno, F F Casanueva
UNLABELLED: Brackground:The safety and tolerability of very low-calorie-ketogenic (VLCK) diets are a current concern in the treatment of obese type 2 diabetes mellitus (T2DM) patients. OBJECTIVE: Evaluating the short-term safety and tolerability of a VLCK diet (<50 g of carbohydrate daily) in an interventional weight loss program including lifestyle and behavioral modification support (Diaprokal Method) in subjects with T2DM. METHODS: Eighty-nine men and women, aged between 30 and 65 years, with T2DM and body mass index between 30 and 35 kg m(-)(2) participated in this prospective, open-label, multi-centric randomized clinical trial with a duration of 4 months...
September 19, 2016: Nutrition & Diabetes
Michal Anděl, Ludmila Brunerová, Pavel Dlouhý, Jan Polák, Jan Gojda, Pavel Kraml
UNLABELLED: Recently, thousands of papers brought knowledge about effects of nutrients on cellular level, in experimental animals and in human experiments on one side, the results of epidemiological studies on the other side have suggested the nutrients and foods for healthy diet and nutrients and foods, which should be consumed only in limited amount. Among foods, which should be avoided, those with higher content of trans-fatty acids. Their daily intake should not exceed 1 % of total energy intake...
2016: Vnitr̆ní Lékar̆ství
Kandy T Velazquez, Reilly T Enos, Meredith S Carson, Taryn L Cranford, Jackie Bader, Ioulia Chatzistamou, Udai Singh, Prakash S Nagarkatti, Mitzi Nagarkatti, J Mark Davis, James A Carson, E Angela Murphy
Obesity presents a significant public health concern given its association with increased cancer incidence, unfavorable prognosis, and metastasis. However, there is very little literature on the effects of weight-loss, following obesity, on risk for colon cancer or liver cancer. Therefore, we sought to study whether intentional weight loss through diet manipulation was capable of mitigating colon and liver cancer in mice. We fed mice with a high-fat diet (HFD) comprised of 47% carbohydrates, 40% fat, and 13% protein for 20 weeks to mimic human obesity...
September 8, 2016: American Journal of Physiology. Gastrointestinal and Liver Physiology
Anita S Elidottir, Thorhallur I Halldorsson, Ingibjörg Gunnarsdottir, Alfons Ramel
BACKGROUND/AIM: Most studies regarding low-carbohydrate diets (LCDs) have been intervention studies. The aim of the current study was to investigate dietary intake and cardiovascular risk factors among individuals who voluntarily follow a LCD. METHODS: A cross-sectional study was conducted (N = 54, 20-66yrs) in Reykjavik, Iceland. Participants recorded food intake for three days. Blood samples were analyzed for cardiovascular risk factors. RESULTS: Nearly half of the participants were obese and around 60% had been on a LCD for ≥ 6 months...
2016: PloS One
Christopher Smyl
Research of the last two decades showed that chronic low-grade inflammation, elevated blood glucose and insulin levels may play role in the onset of a number of non-communicable diseases such as type 2 diabetes and some forms of cancer. Regular exercise and fasting can ameliorate high blood glucose and insulin levels as well as increase the concentration of plasma ketone bodies. These, in consequence, may lead to reduction of inflammation. Exercise or severe restriction of caloric intake is not always advisable for patients, in particular those suffering from cancer...
2016: Recent Results in Cancer Research
Diana M Cheng, Diana E Roopchand, Alexander Poulev, Peter Kuhn, Isabel Armas, William D Johnson, Andrew Oren, David Ribnicky, Ehud Zelzion, Debashish Bhattacharya, Ilya Raskin
SCOPE: The ability of high phenolic Rutgers Scarlet Lettuce (RSL) to attenuate metabolic syndrome and gut dysbiosis was studied in very high fat diet (VHFD)-fed mice. Phenolic absorption was assessed in vivo and in a gastrointestinal tract model. METHODS AND RESULTS: Mice were fed VHFD, VHFD supplemented with RSL (RSL-VHFD) or store-purchased green lettuce (GL-VHFD), or low-fat diet (LFD) for 13 weeks. Compared to VHFD or GL-VHFD-fed groups, RSL-VHFD group showed significantly improved oral glucose tolerance (p<0...
August 16, 2016: Molecular Nutrition & Food Research
Megan L Gow, Sarah P Garnett, Louise A Baur, Natalie B Lister
Type 2 diabetes in children and adolescents has become a prominent clinical issue in recent decades. Increasing numbers of young people have risk factors for type 2 diabetes, particularly obesity, indicating the need for effective type 2 diabetes prevention strategies. The aim of this review was to identify specific dietary strategies that optimize improvements in risk factors for type 2 diabetes in youth and hence reduce the risk of type 2 diabetes development. Our review of the current literature indicates that dietary interventions lead to weight loss when intervention adherence is high...
2016: Nutrients
Thomas P Wycherley, Campbell H Thompson, Jonathan D Buckley, Natalie D Luscombe-Marsh, Manny Noakes, Gary A Wittert, Grant D Brinkworth
BACKGROUND AND AIMS: Very-low carbohydrate diets can improve glycaemic control in patients with type 2 diabetes (T2DM). However, compared to traditional higher carbohydrate, low fat (HighCHO) diets, they have been associated with impaired endothelial function (measured by flow mediated dilatation [FMD]) that is possibly related to saturated fat. This study aimed to examine the effects of a 12-month hypocaloric very-low carbohydrate, low saturated fat (LowCHO) diet compared to an isocaloric HighCHO diet...
September 2016: Atherosclerosis
Mette Cathrine Ørngreen
The main purpose of the following studies was to investigate pathophysiological mechanisms in fat and carbohydrate metabolism and effect of nutritional interventions in patients with metabolic myopathies and in patients with severe muscle wasting. Yet there is no cure for patients with skeletal muscle disorders. The group of patients is heterozygous and this thesis is focused on patients with metabolic myopathies and low muscle mass due to severe muscle wasting. Disorders of fatty acid oxidation (FAO) are, along with myophosphorylase deficiency (McArdle disease), the most common inborn errors of metabolism leading to recurrent episodes of rhabdomyolysis in adults...
July 2016: Danish Medical Journal
G Merra, R Miranda, S Barrucco, P Gualtieri, M Mazza, E Moriconi, M Marchetti, T F M Chang, A De Lorenzo, L Di Renzo
OBJECTIVE: Obesity plays a relevant pathophysiological role in the development of health problems, arising as result of complex interaction of genetic, nutritional and metabolic factors. We conducted a dietary intervention case-control randomized trial, to compare the effectiveness on body composition of two nutritional protocols: a very-low-carbohydrate ketogenic diet (VLCKD), integrated by an aminoacid supplement with whey protein, and very low restricted-calorie diet (VLCD). PATIENTS AND METHODS: The clinical study was conducted with a randomized case-control in which twenty-five healthy subjects gave informed consent to participate in the interventional study and were evaluated for their health and nutritional status, by anthropometric, and body composition evaluation...
July 2016: European Review for Medical and Pharmacological Sciences
Catherine Saenz, Daniel J Freidenreich, Laura J Kunces, Jenna M Bartley, Brent C Creighton, Giselle A Aerni, Jeffrey M Anderson, Patrick M Davitt, Colleen X Munoz, Elaine C Lee, Stephen O Opiyo, Carl M Maresh, William J Kraemer, Jeff S Volek
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
Grant Martin Schofield, George Henderson, Simon Thornley
Humans can derive energy from carbohydrate, fat, or protein. The metabolism of carbohydrate requires by far the highest secretion of insulin. The central pathology of diabetes is the inability to maintain euglycaemia because of a deficiency in either the action or secretion of insulin. That is, because of either insulin resistance often accompanied by hyperinsulinaemia, or insulin deficiency caused by pancreatic beta cell failure. In individuals dependent on insulin and other hypoglycaemic medication, the difficulty of matching higher intakes of carbohydrates with the higher doses of medication required to maintain euglycaemia increases the risk of adverse events, including potentially fatal hypoglycaemic episodes...
April 1, 2016: New Zealand Medical Journal
Linjing Zhao, Yan Ni, Xiaojing Ma, Aihua Zhao, Yuqian Bao, Jiajian Liu, Tianlu Chen, Guoxiang Xie, Jun Panee, Mingming Su, Herbert Yu, Congrong Wang, Cheng Hu, Weiping Jia, Wei Jia
Increasing evidences support that metabolically healthy obese (MHO) is a transient state. However, little is known about the early markers associated with the development of metabolic abnormalities in MHO individuals. Serum free fatty acids (FFAs) profile is highlighted in its association with obesity-related insulin resistance, type 2 diabetes mellitus (T2DM) and cardiovascular diseases (CVD). To examine the association of endogenous fatty acid metabolism with future development of metabolic abnormalities in MHO individuals, we retrospectively analyzed 24 [product FFA]/[precursor FFA] ratios in fasting sera and clinical data from 481 individuals who participated in three independent studies, including 131 metabolic healthy subjects who completed the 10-year longitudinal Shanghai Diabetes Study (SHDS), 312 subjects cross-sectionally sampled from the Shanghai Obesity Study (SHOS), and 38 subjects who completed an 8-week very low carbohydrate diet (VLCD) intervention study...
2016: Scientific Reports
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