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https://www.readbyqxmd.com/read/29206473/carbonyl-iron-powder-a-reagent-for-nitro-group-reductions-under-aqueous-micellar-catalysis-conditions
#1
Nicholas R Lee, Agata A Bikovtseva, Margery Cortes-Clerget, Fabrice Gallou, Bruce H Lipshutz
An especially mild, safe, efficient, and environmentally responsible reduction of aromatic and heteroaromatic nitro-group-containing educts is reported that utilizes very inexpensive carbonyl iron powder (CIP), a highly active commercial grade of iron powder. These reductions are conducted in the presence of nanomicelles composed of TPGS-750-M in water, a recyclable aqueous micellar reaction medium. This new technology also shows broad scope and scalability and presents opportunities for multistep one-pot sequences involving this reducing agent...
December 5, 2017: Organic Letters
https://www.readbyqxmd.com/read/29193350/curcumin-nanomicelle-improves-semen-parameters-oxidative-stress-inflammatory-biomarkers-and-reproductive-hormones-in-infertile-men-a-randomized-clinical-trial
#2
Fatemeh Alizadeh, Maryam Javadi, Ali Akbar Karami, Fereshteh Gholaminejad, Maria Kavianpour, Hossein Khadem Haghighian
At least 50% of infertile couple's problems are related to male factor infertility. This Randomized, Double-Blind, Placebo-Controlled Clinical Trial conducted in Urology unit of Infertility Clinic on 60 infertile men. Patients were randomly assigned to one of intervention and placebo (n = 30) groups. Finally, 28 subjects in each group completed the study. Participants in the intervention group took daily 80 mg curcumin nanomicelle and those in the placebo group took daily placebo for 10 weeks. Semen analysis, anthropometric, physical activity assessments, total antioxidant capacity, malondialdehyde, inflammatory factors, and reproductive hormones were measured at the baseline and at the end of the study...
November 28, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29179722/aminoglucose-functionalized-redox-responsive-polymer-nanomicelles-for-overcoming-chemoresistance-in-lung-cancer-cells
#3
Yi Zhou, Huaying Wen, Liang Gu, Jijun Fu, Jiayi Guo, Lingran Du, Xiaoqin Zhou, Xiyong Yu, Yugang Huang, He Wang
BACKGROUND: Chemotherapeutic drugs used for cancer therapy frequently encounter multiple-drug resistance (MDR). Nanoscale carriers that can target tumors to accumulate and release drugs intracellularly have the greatest potential for overcoming MDR. Glucose transporter-1 (GLUT-1) and glutathione (GSH) overexpression in cancer cells was exploited to assemble aminoglucose (AG)-conjugated, redox-responsive nanomicelles from a single disulfide bond-bridged block polymer of polyethylene glycol and polylactic acid (AG-PEG-SS-PLA)...
November 28, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/29177974/antitumor-activity-of-raloxifene-targeted-poly-styrene-maleic-acid-poly-amide-ether-ester-imide-co-polymeric-nanomicelles-loaded-with-docetaxel-in-breast-cancer-bearing-mice
#4
Saeede Enteshari, Jaleh Varshosaz, Mohsen Minayian, Farshid Hassanzadeh
Purpose Raloxifene (RA) receptors have over-expressed GPER-positive breast cancer tumors. The purpose of this work was to evaluate the antitumor activity and pharmacokinetic behavior of docetaxel (DTX), loaded in RA-targeted nanomicelles, which were designed to overcome a lack of specific distribution and inadequate DTX concentration in tumor tissues, as well as its cytotoxicity and damage to normal tissues. Methods DTX-loaded RA-targeted poly(styrene maleic acid) (SMA)- poly(amide-ether-esterimide)-poly(ethylene glycol) (PAEEI-PEG) nanomicelles were prepared; then, their antitumor activity and survival rate were studied in MC4-L2 tumors induced in BALB/c mice...
November 27, 2017: Investigational New Drugs
https://www.readbyqxmd.com/read/29156337/facile-preparation-of-core-cross-linked-nanomicelles-based-on-graft-copolymers-with-ph-responsivity-and-reduction-sensitivity-for-doxorubicin-delivery
#5
Tiandong Chen, Yi Xiao, Wei Lu, Shiyuan Liu, Lin Gan, Jiahui Yu, Jin Huang
To achieve passive targeting and controlled drug release at tumor sites trigged by low pH value and high level of glutathione (GSH), optimized delivery system for doxorubicin (DOX) based on core cross-linked nanomicelles was developed in this research. Particularly, methoxypoly(ethylene glycol)-nitrophenyl carbonate (mPEG-NPC) and 3,4-dihydroxyphenylaceticacid were grafted onto synthesized poly(N,N'-cystamine bisacrylamide-N-Boc-1,2-diaminoethane) (poly(CBA-DAE)) to give methoxypoly(ethylene glycol)-g-poly(N,N'-cystamine bisacrylamide-N-Boc-1, 2-diaminoethane)-g-3, 4-dihydroxyphenylaceticacid (mPEG-g-SS-PCD-DA)...
November 16, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29145770/camptothecin-prodrug-nanomicelle-based-on-a-boronate-ester-linked-diblock-copolymer-as-the-carrier-of-doxorubicin-with-enhanced-cellular-uptake
#6
Ya Gao, Yi Xiao, Shiyuan Liu, Jiahui Yu
A novel pH-sensitive polymeric prodrug of camptothecin (CPT) by polymerizing γ-camptothecin-glutamate N-carboxyanhydride (Glu (CPT)-NCA) on boronate ester-linked poly (ethyleneglycol) (PEG) directly via the amine-initiated ring open polymerization (ROP) has been developed. The resulting amphiphilic prodrug (mPEG-BC-PGluCPT) could self-assemble into nanoparticles and encapsulate doxorubicin (Dox) simultaneously in aqueous solution for dual-drug delivery. The formation of polymeric prodrug micelles (mPEG-BC@PGluCPT) was confirmed by the measurements of critical aggregation concentration (CAC), particle size, and morphology observations...
November 17, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/29144767/evaluation-of-polyvinyl-caprolactam-polyvinyl-acetate-polyethylene-glycol-graft-copolymer-nanomicelle-for-trigeminal-ganglion-neurons-delivering-with-intranasal-administration
#7
Mengshuang Li, Meng Xin, Kaichao Song, Fengyuan Sun, Yuzhen Hou, Jun Li, Xianggen Wu
Purpose How to deliver enough medical agents to the trigeminal ganglion (TG) neurons conveniently still remains a challenge in pharmaceutics and clinics. The purpose of this study was to reveal that intranasal administration of polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer (PVCL-PVA-PEG) nanomicelle formulation could efficiently deliver agent to TG neurons in mice. Methods Ocular topical or intranasal administration of nanomicelle coumarin-6 was performed in mice, and tissue distribution after administration (0...
November 16, 2017: Current Eye Research
https://www.readbyqxmd.com/read/29132238/nanomicelle-drug-with-acid-triggered-doxorubicin-release-and-enhanced-cellular-uptake-ability-based-on-mpeg-graft-poly-n-2-aminoethyl-l-aspartamide-hexahydrophthalic-acid-copolymers
#8
Li Cao, Yi Xiao, Wei Lu, Shiyuan Liu, Lin Gan, Jiahui Yu, Jin Huang
In order to achieve the passive tumor targeting and acid-triggered drugs release in lysosomes, optimized delivery system for doxorubicin based on pH-sensitive complex nanomicelles with suitable particle size was developed in this research. Particularly, poly(L-succinimide) was thoroughly ring-opened by ethylenediamine to give the poly(N-(2-aminoethyl)-L-aspartamide). Then, graft copolymer mPEG-graft-poly(N-(2-aminoethyl)-L-aspartamide)-hexahydrophthalic acid (mPEG-g-P(ae-Asp)-Hap) was synthesized by grafting mPEG-2000 and hexahydrophthalic anhydride onto poly(N-(2-aminoethyl)-L-aspartamide)...
January 1, 2017: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/29120077/self-assembled-nanomicelles-as-mri-blood-pool-contrast-agent
#9
Andrej Babic, Vassily Vorobiev, Celine Xayaphoummine, Gaelle Lapicorey, Anne-Sophie Chauvin, Lothar Helm, Eric Allémann
Gadolinium-loaded nanomicelles show promise as future magnetic resonance imaging (MRI) contrast agents (CAs). Their increased size and high gadolinium (Gd) loading gives them an edge in proton relaxivity over smaller molecular Gd-complexes. Their size and stealth properties are fundamental for their long blood residence time opening the possibility for use as blood-pool contrast agents. Using L-tyrosine as a three-functional scaffold we synthesized a nanostructure building block 8. The double C18 aliphatic chain on one side, Gd-DO3A with access to bulk water in the center and 2 kDa PEG on the hydrophilic side gave the amphiphilic properties required for the core-shell nanomicellar architecture...
November 9, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29075114/a-bone-resorption-surface-targeting-nanoparticle-to-deliver-anti-mir214-for-osteoporosis-therapy
#10
Mingxiang Cai, Li Yang, Shufan Zhang, Jiafan Liu, Yao Sun, Xiaogang Wang
With increasing fracture risks due to fragility, osteoporosis is a global health problem threatening postmenopausal women. In these patients, osteoclasts play leading roles in bone loss and fracture. How to inhibit osteoclast activity is the key issue for osteoporosis treatment. In recent years, miRNA-based gene therapy through gene regulation has been considered a potential therapeutic method. However, in light of the side effects, the use of therapeutic miRNAs in osteoporosis treatment is still limited by the lack of tissue/cell-specific delivery systems...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29066896/aminated-nanomicelles-as-a-designer-vaccine-adjuvant-to-trigger-inflammasomes-and-multiple-arms-of-the-innate-immune-response-in-lymph-nodes
#11
Chanyoung Song, Hathaichanok Phuengkham, Sun-Young Kim, Min Sang Lee, Ji Hoon Jeong, Sung Jae Shin, Yong Taik Lim
In this study, we suggest a designer vaccine adjuvant that can mimic the drainage of pathogens into lymph nodes and activate innate immune response in lymph nodes. By the amination of multivalent carboxyl groups in poly-(γ-glutamic acid) (γ-PGA) nanomicelles, the size was reduced for rapid entry into lymphatic vessels, and the immunologically inert nanomicelles were turned into potential activators of inflammasomes. Aminated γ-PGA nanomicelles (aPNMs) induced NLRP3 inflammasome activation and the subsequent release of proinflammatory IL-1β...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29057491/insight-into-curcumin-nanomicelle-induced-derangements-in-male-reproduction-potential-an-experimental-study
#12
S Moshari, V Nejati, G Najafi, M Razi
This study was conducted to investigate the possible effects of nanomicelle curcumin (NMC) on spermatogenesis, sperm parameters and in vitro fertilisation potential. For this purpose, 24 mature male Wistar rats were divided into control and test groups. The animals in test groups received 7.5, 15 and 30 mg kg b.w(-1) of NMC (NO = 6 rats in each group). Following 48 days, the DNA integrity of testicular tissues, tubular differentiation (TDI) and spermiogenesis (SPI) indices, sperm parameters and DNA integrity were analysed...
October 23, 2017: Andrologia
https://www.readbyqxmd.com/read/29043860/development-and-in-vitro-in-vivo-evaluation-of-hpmc-chitosan-gel-containing-simvastatin-loaded-self-assembled-nanomicelles-as-a-potent-wound-healing-agent
#13
Jaleh Varshosaz, Somayeh Taymouri, Mohsen Minaiyan, Fatemeh Rastegarnasab, Azar Baradaran
The aim of this study was to develop hydroxypropyl methyl cellulose (HPMC)/chitosan gel containing polymeric micelles loaded with simvastatin (Sim) and evaluates its wound healing properties in rats. An irregular full factorial design was employed to evaluate the effects of various formulation variables including polymer/drug ratio, hydration temperature, hydration time and organic solvent type on the physicochemical characteristics of pluronic F127-cholesterol nanomicelles prepared using the film hydration method...
October 18, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/29040803/synthesis-and-characterization-of-fatty-acid-grafted-chitosan-polymer-and-their-nanomicelles-for-nonviral-gene-delivery-applications
#14
Divya Sharma, Jagdish Singh
The aim of this study was to synthesize and characterize fatty acid-grafted-chitosan (fatty acid-g-CS) polymer and their nanomicelles for use as carriers for gene delivery. CS was hydrophobically modified using saturated fatty acids of increasing fatty acyl chain length. Carbodiimide along with N-hydroxysuccinimide was used for coupling carboxyl group of fatty acids with amine groups of CS. Proton nuclear magnetic resonance and Fourier transform infrared spectroscopy were used to quantify fatty acyl substitution onto CS backbone...
October 23, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/29033567/nanoparticles-for-the-treatment-of-liver-fibrosis
#15
REVIEW
Suchithra Poilil Surendran, Reju George Thomas, Myeong Ju Moon, Yong Yeon Jeong
Chronic liver diseases represent a global health problem due to their high prevalence worldwide and the limited available curative treatment options. They can result from various causes, both infectious and noninfectious diseases. The application of nanoparticle (NP) systems has emerged as a rapidly evolving area of interest for the safe delivery of various drugs and nucleic acids for chronic liver diseases. This review presents the pathogenesis, diagnosis and the emerging nanoparticulate systems used in the treatment of chronic liver diseases caused by liver fibrosis...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29019073/cholecalciferol-peg-conjugate%C3%A2-based-nanomicelles-of-doxorubicin-for-treatment-of-triple-negative-breast-cancer
#16
Shallu Kutlehria, Gautam Behl, Ketan Patel, Ravi Doddapaneni, Imran Vhora, Nusrat Chowdhury, Arvind Bagde, Mandip Singh
Triple-negative breast cancer (TNBC) is the leading cancer in women. Chemotherapeutic agents used for TNBC are mainly associated with dose-dependent toxicities and development of resistance. Hence, novel strategies to overcome resistance and to offer dose reduction are warranted. In this study, we designed a novel dual-functioning agent, conjugate of cholecalciferol with PEG2000 (PEGCCF) which can self-assemble into micelles to encapsulate doxorubicin (DOX) and act as a chemosensitizer to improve the therapeutic potential of DOX...
October 10, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28977853/application-of-luteolin-nanomicelles-anti-glioma-effect-with-improvement-in-vitro-and-in-vivo
#17
Songping Zheng, Yongzhong Cheng, Yan Teng, Xiaoxiao Liu, Ting Yu, Yi Wang, Jiagang Liu, Yuzhu Hu, Cong Wu, Xiang Wang, Yanhui Liu, Chao You, Xiang Gao, Yuquan Wei
Glioblastoma multiforme (GBM) is one of the most common and malignant tumor. Luteolin, a polyphenolic compound, has been proposed to have anti-tumor activity against various cancers. However, the greatest obstacle in the administration of luteolin is its hydrophobicity as well as the low oral bioavailability. In this study, we formulated luteolin-loaded MPEG-PCL (Luteolin/MPEG-PCL) micelles aiming to improve its solubility in aqueous solution and investigate the anti-tumor effect on glioma in vitro and in vivo...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28927842/synthesis-and-preparation-of-biodegradable-hybrid-dextran-hydrogel-incorporated-with-biodegradable-curcumin-nanomicelles-for-full-thickness-wound-healing
#18
Mona Alibolandi, Marzieh Mohammadi, Seyed Mohammad Taghdisi, Khalil Abnous, Mohammad Ramezani
There is a clinical need for a novel, more efficient therapy for full thickness wound healing. In the current study, curcumin encapsulated PEG-PLA [poly(lactide)-block-poly(ethylene glycol)] nanomicelles were incorporated into dextran hydrogel for a full thickness dermal wound healing application. To assess the application of the hydrogel as a therapeutic wound dressing, its morphology, swelling pattern, kinetics of degradation, and capacity to control curcumin release were evaluated. It was found that the prepared hybrid hydrogel had acceptable biocompatibility, incorporation capacity of curcumin nanomicelles, and mechanical properties...
September 18, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28912886/the-ph-triggered-triblock-nanocarrier-enabled-highly-efficient-sirna-delivery-for-cancer-therapy
#19
Lili Du, Junhui Zhou, Lingwei Meng, Xiaoxia Wang, Changrong Wang, Yuanyu Huang, Shuquan Zheng, Liandong Deng, Huiqing Cao, Zicai Liang, Anjie Dong, Qiang Cheng
Small interfering RNA (siRNA) therapies have been hampered by lack of delivery systems in the past decades. Nowadays, a few promising vehicles for siRNA delivery have been developed and it is gradually revealed that enhancing siRNA release from endosomes into cytosol is a very important factor for successful delivery. Here, we designed a novel pH-sensitive nanomicelle, PEG-PTTMA-P(GMA-S-DMA) (PTMS), for siRNA delivery. Owing to rapid hydrolysis in acidic environment, PTMS NPs underwent hydrophobic-to-hydrophilic transition in endosomes that enabled combination of proton sponge effect and raised osmotic pressure in endosomes, resulting in vigorous release of siRNAs from endosomes into cytosol...
2017: Theranostics
https://www.readbyqxmd.com/read/28887099/enhancing-biopharmaceutical-performance-of-an-anticancer-drug-by-long-chain-pufa-based-self-nanoemulsifying-lipidic-nanomicellar-system
#20
Rajneet Kaur Khurana, Sarwar Beg, Andrea Julie Burrow, Rakesh K Vashishta, O P Katare, Satvinder Kaur, Prashant Kesherwani, Kamalinder K Singh, Bhupinder Singh
The aim of this study was to develop polyunsaturated fatty acid (PUFA) long chain glyceride (LCG) enriched self-nanoemulsifying lipidic nanomicelles systems (SNELS) for augmenting lymphatic uptake and enhancing oral bioavailability of docetaxel and compare its biopharmaceutical performance with a medium-chain fatty acid glyceride (MCG) SNELS. Equilibrium solubility and pseudo ternary phase studies facilitated the selection of suitable LCG and MCG. The critical material attributes (CMAs) and critical process parameters (CPPs) were earmarked using Placket-Burman Design (PBD) and Fractional Factorial Design (FFD) for LCG- and MCG-SNELS respectively, and nano micelles were subsequently optimized using I- and D-optimal designs...
September 5, 2017: European Journal of Pharmaceutics and Biopharmaceutics
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