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https://www.readbyqxmd.com/read/28532112/preparations-and-doxorubicin-controlled-release-of-amino-acid-based-redox-ph-dual-responsive-nanomicelles
#1
Yuanyuan Ding, Liping Zhang, Gang Shi, Xinxin Sang, Caihua Ni
Terpolymers of poly (Lysine-co-N, N-Bis (acryloyl) cystamine-co-β-Phenethylamine) (PLBP) were synthesized in one-pot by Michael addition terpolymerization. The terpolymers self-assembled into nano-sized spherical micelles (84-123nm) with narrow distributions. The surface charge of the nanomicelles (NMs) was depended on solution's pH and showed negative values under physiological conditions (pH7.4), which was beneficial for long circulation without non-specific protein adsorption. Doxorubicin (DOX) was effectively loaded into the NMs for controlled release...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28531980/self-assembled-nanomicelles-of-damnacanthal-loaded-amphiphilic-modified-chitosan-preparation-characterization-and-cytotoxicity-study
#2
Pakin Sukamporn, Seung Joon Baek, Wandee Gritsanapan, Suwabun Chirachanchai, Thararat Nualsanit, Pleumchitt Rojanapanthu
Damnacanthal (Dam) is a phytochemical with many pharmacological properties including anticancer activity. However, its hydrophobicity, poor bioavailability and stability limit its application in many biological approaches. In this study, Dam nanomicelles as an emerging platform were developed to overcome limitations. The deoxycholic and poly(ethylene glycol) methyl ether grafted chitosan (DCA-CS-mPEG) was synthesized and characterized by FTIR and (1)H NMR and the degree of substitution (DS) was determined by elemental analysis (EA)...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28526600/preparation-and-nanoformulation-of-new-quinolone-scaffold-based-anticancer-agents-enhancing-solubility-for-better-cellular-delivery
#3
Nehal H Elghazawy, Amr Hefnawy, Nada K Sedky, Ibrahim M El-Sherbiny, Reem K Arafa
A new series of 5,7-dibromoquinoline scaffold-based derivatives with varied flexibility substituents at position 8 of the ring system has been synthesized as potential anticancer agents. The new compounds were evaluated for their in vitro antiproliferative activity versus the human breast cancer cell lines MCF-7 and MDA-MB231. Generally, both cell lines were responsive to the cytotoxic effect of the synthesized analogues. Compounds 4a, 5c and 7b were chosen for nanoformulation studies to assess the effect of enhancing their solubility profile on their cytotoxic ability...
May 17, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28524805/polymeric-nanomicelles-a-potential-hazard-for-the-cardiovascular-system
#4
Yazhou Wang, Guixue Wang
No abstract text is available yet for this article.
May 19, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28515763/poly-ethylene-co-vinyl-alcohol-based-polymeric-thermo-responsive-nanocarriers-for-controlled-delivery-of-epirubicin-to-hepatocellular-carcinoma
#5
Farshid Hassanzadeh, Maryam Farzan, Jaleh Varshosaz, Ghadam Ali Khodarahmi, Sahar Maaleki, Mahboubeh Rostami
In this study, poly(ethylene-co-vinyl alcohol) (EVOH) as a novel biocompatible polymeric scaffold was surface modified by succinylation to get EVOHS and further pegylated to improve structural properties using methoxypolyethylene glycol (5000 Da) succinate (PEGS) along with targeting with retinoic acid (RA) to get final modified active and passive targeted conjugate (PEGS-EVOHS-RA) to evaluate its ability in carrying and delivery of epirubicin to hepatocellular carcinoma cell lines in response to varying temperatures...
April 2017: Research in Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28480807/tri-block-co-polymer-nanocarriers-for-enhancement-of-oral-delivery-of-felodipine-preparation-in-vitro-characterization-and-ex-vivo-permeation
#6
Sinar Sayed Fouad, Basant A Habib, Ghada M Elsayed
This study aimed to prepare, optimize and characterize a novel felodipine- loaded polymeric nanomicelles, using a pluronic mixture of F127 and P123. Thin-film hydration method was adopted for the preparation of different polymeric nanomicelles (T1-T12) according to a 4(1).3(1) full factorial design. Factors studied were: Pluronic ®: drug ratio (P:D ratio) (10, 20, 30 and 40 w/w) and percent of hydrophilic polymer (F127%) (33.33%, 50% and 66.67% w/w). Optimization criteria were to maximize transmittance percent (T%) and entrapment efficiency percent (EE%) and to minimize particle size (PS) and polydispersity index (PDI)...
May 7, 2017: Journal of Liposome Research
https://www.readbyqxmd.com/read/28471177/topical-formulation-of-self-assembled-antiviral-prodrug-nanomicelles-for-targeted-retinal-delivery
#7
Abhirup Mandal, Kishore Cholkar, Varun Khurana, Ankit Shah, Vibhuti Agrahari, Rohit Bisht, Dhananjay Pal, Ashim K Mitra
Topical drug administration for back of the eye delivery is extremely challenging due to the presence of protection mechanisms and physiological barriers. Self-assembled polymeric nanomicelles have emerged as promising vehicles for drug delivery. Apart from serving as an inert nanocarrier for therapeutic agents, polymeric nanomicelles are known to bypass mononuclear phagocytic system (MPS) and efflux transporters thereby improving drug bioavailability. In this investigation, a highly efficacious biotinylated lipid prodrug of cyclic cidofovir (B-C12-cCDF) was formulated within polymeric nanomicelles as a carrier for targeted retinal delivery...
May 17, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28463810/rational-design-of-hybrid-nanomicelles-integrating-mucosal-penetration-and-p-glycoprotein-inhibition-for-efficient-oral-delivery-of-paclitaxel
#8
He Lian, Zhonggui He, Zhaoxu Meng
A dual functional TPGS-succinic acid-mercaptoethylamine (TPGS-SH) material was synthesized to improve the oral absorption of anticancer drugs, aiming to integrate the advantages of mucosal penetration with P-glycoprotein (P-gp) inhibition. Paclitaxel-loaded hybrid nanomicelles (CS-VES/TPGS-SH) with a uniform particle size (234.2-273.9nm), high drug loading (11.50±0.91%), and good encapsulation efficiency (86.18±3.73%) were fabricated. The absorption rate and apparent permeability coefficient were significantly improved in the whole intestine, especially in the duodenum segment, with a 3...
April 23, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28458188/a-differential-approach-towards-understanding-the-enhanced-emission-induced-superior-bio-imaging-and-cytotoxicity-within-block-copolymeric-nanomicelles
#9
Soumyadipta Rakshit, Arindam Sarkar, Subhash Chandra Bhattacharya
Two tri-block copolymers P123 (PEO19PPO69PEO19) and F127 (PEO100PPO65PEO100) have been employed to form polymeric nanomicelles and function as potential nanocarriers for an anticancer pyrazoline derivative (PYZ) in aqueous buffer solution for biological studies. Encapsulation within these nanomicelles considerably enhanced the fluorescence of the PYZ compared to its low fluorescence in aqueous buffer medium. The effect of the micellar structures on the photophysical properties of PYZ have been demonstrated by means of steady state and time resolved fluorescence spectroscopy...
April 20, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28440698/therapeutic-peg-ceramide-nanomicelles-synergize-with-salinomycin-to-target-both-liver-cancer-cells-and-cancer-stem-cells
#10
Meiping Wang, Fangyuan Xie, Xikai Wen, Han Chen, Hai Zhang, Junjie Liu, He Zhang, Hao Zou, Yuan Yu, Yan Chen, Zhiguo Sun, Xinxia Wang, Guoqing Zhang, Chuan Yin, Duxin Sun, Jie Gao, Beige Jiang, Yanqiang Zhong, Ying Lu
AIM: Salinomycin (SAL)-loaded PEG-ceramide nanomicelles (SCM) were prepared to target both liver cancer cells and cancer stem cells. MATERIALS & METHODS: The synergistic ratio of SAL/PEG-ceramide was evaluated to prepare SCM, and the antitumor activity of SCM was examined both in vitro and in vivo. RESULTS: SAL/PEG-ceramide molar ratio of 1:4 was chosen as the synergistic ratio, and SCM showed superior cytotoxic effect and increased apoptosis-inducing activity in both liver cancer cells and cancer stem cells...
May 2017: Nanomedicine
https://www.readbyqxmd.com/read/28420213/folate-decorated-nanomicelles-loaded-with-a-potent-curcumin-analogue-for-targeting-retinoblastoma
#11
Hashem Alsaab, Rami M Alzhrani, Prashant Kesharwani, Samaresh Sau, Sai Hs Boddu, Arun K Iyer
The aim of this study was to develop a novel folate receptor-targeted drug delivery system for retinoblastoma cells using a promising anticancer agent, curcumin-difluorinated (CDF), loaded in polymeric micelles. Folic acid was used as a targeting moiety to enhance the targeting and bioavailability of CDF. For this purpose, amphiphilic poly(styrene-co-maleic acid)-conjugated-folic acid (SMA-FA) was synthesized and utilized to improve the aqueous solubility of a highly hydrophobic, but very potent anticancer compound, CDF, and its targeted delivery to folate overexpressing cancers...
April 18, 2017: Pharmaceutics
https://www.readbyqxmd.com/read/28408816/zonisamide-loaded-triblock-copolymer-nanomicelles-as-a-novel-drug-delivery-system-for-the-treatment-of-acute-spinal-cord-injury
#12
JingLun Li, JiaoJiao Deng, JinXian Yuan, Jie Fu, XiaoLing Li, AiPing Tong, YueLong Wang, YangMei Chen, Gang Guo
Spinal cord injury (SCI) commonly leads to lifelong disability due to the limited regenerative capacity of the adult central nervous system. Nanomicelles can be used as therapeutic systems to provide effective treatments for SCI. In this study, a novel triblock monomethyl poly(ethylene glycol)-poly(l-lactide)-poly(trimethylene carbonate) copolymer was successfully synthesized. Next, polymeric nanomicelles loaded with zonisamide (ZNS), a Food and Drug Administration-approved antiepileptic drug, were prepared and characterized...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28385400/nanomicelle-curcumin-induced-dna-fragmentation-in-testicular-tissue-correlation-between-mitochondria-dependent-apoptosis-and-failed-pcna-related-hemostasis
#13
Sana Moshari, Vahid Nejati, Gholamreza Najafi, Mazdak Razi
Current study was done to assess possible anti-proliferative effect of nanomicelle curcumin (NMCM) against germ cells in testicular tissue. For this purpose, 24 mature male Wistar rats were divided into control and test groups. The animals in test groups received 7.5mg/kg, 15mg/kg and 30mg/kg of NMC (NO=6 rats in each group). Following 48days, the expression of Bcl-2, Bax, caspase-3, P53 and proliferating cell nuclear antigen (PCNA) were evaluated by using reverse transcription-PCR and immunohistochemistry...
April 3, 2017: Acta Histochemica
https://www.readbyqxmd.com/read/28377319/development-of-extended-voyaging-anti-oxidant-linked-amphiphilic-polymeric-nanomicelles-for-anti-tuberculosis-drug-delivery
#14
Rajendran Amarnath Praphakar, Murugan A Munusamy, Mariappan Rajan
Amphiphilic chitosan-graft-poly(caprolactone)/(ferulic acid) (CS-g-PCL/FA) multi-co-polymers were fabricated by microwave-assisted ring opening polymerization followed by an 1-ethyl-3-(3-dimethyl-aminopropyl) carbodiimide (EDC)-mediated coupling reaction and characterized by Fourier transformed infrared (FTIR) spectroscopy. Graft copolymers self-assembled into nanomicelles, and were able to incorporate rifampicin (RF) into their hydrophobic inner cores. X-ray diffraction (XRD) patterns were applied to characterize the crystal structures of graft polymers and the effects of RF on micelle morphology...
April 2, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28323118/mixed-poly-vinyl-pyrrolidone-based-drug-loaded-nanomicelles-shows-enhanced-efficacy-against-pancreatic-cancer-cell-lines
#15
Anisha Veeren, Archana Bhaw-Luximon, Debabrata Mukhopadhyay, Dhanjay Jhurry
We report in this paper on the enhanced efficacy of a physical mixture of two single anti-cancer loaded nanomicelles against PANC-1 and BxPC-3. Poly(vinyl pyrrolidone-b-polycaprolactone) (PVP-b-PCL) and poly(vinyl pyrrolidone-b-poly(dioxanone-co-methyl dioxanone)) (PVP-b-P(DX-co-MeDX)) were synthesized and successfully loaded with various anti-cancer drugs - gemcitabine (GEM), doxorubicin.HCl (DOX.HCl), doxorubicin.NH2 (DOX), 5-fluorouracil (5-FU) and paclitaxel (PTX). Spherical micelles of size 160-477 nm were obtained as characterized by DLS while sizes determined by TEM were in the range 140-250 nm...
March 18, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28314988/polymeric-micelles-as-mighty-nanocarriers-for-cancer-gene-therapy-a-review
#16
REVIEW
Mahsa Yousefpour Marzbali, Ahmad Yari Khosroushahi
PURPOSE: Gene therapy has shown extensive potential to treat human diseases occurring from the defection of genes like various types of cancers. The cationic polymers, as non-viral gene carriers, offer the ability to engineer carrier systems having customized features that can be adapted to suit any system. Upon polymeric micelle systems' core-shell structure, micelles can create the capacity to load genes/gene-drugs into the different micelle compartments, respectively. METHODS: The search will be managed in Pubmed, Medline, Cochrane library, Embase and Proquest for articles related to polymeric micelle-based gene delivery in order to cancer gene therapy using the accommodative search terms...
March 17, 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/28260893/enhancing-the-oral-bioavailability-of-biochanin-a-by-encapsulation-in-mixed-micelles-containing-pluronic-f127-and-plasdone-s630
#17
Xiaoyan Wu, Weihong Ge, Tengfei Shao, Weijun Wu, Jian Hou, Li Cui, Jing Wang, Zhenghai Zhang
Biochanin A (BCA), a natural dietary isoflavone, has been reported to show anticancer activities. However, its low biological availability and poor aqueous solubility limit its usefulness as a chemotherapeutic agent. We developed BCA-loaded micelles with Pluronic F127 and Plasdone S630 (BCA-FS). The optimized, spherical-shaped BCA-FS was obtained at a ratio of 1:1 (F127:S630). The particle size was 25.17±1.2 nm, and the zeta potential was -10.9±0.24 mV. BCA solubility in water increased to 5.0 mg/mL after encapsulation, and the drug-loading efficiency was 5...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28166625/indocyanine-green-labeled-polysarcosine-for-in-vivo-photoacoustic-tumor-imaging
#18
Kohei Sano, Manami Ohashi, Kengo Kanazaki, Akira Makino, Ning Ding, Jun Deguchi, Yuko Kanada, Masahiro Ono, Hideo Saji
Photoacoustic (PA) imaging has been considered an attractive imaging modality for sensitive and in-depth imaging of biomolecules with a high resolution in vivo. PA imaging probes utilizing fluorescence dyes, including indocyanine green (ICG), have been proposed to enhance PA signal intensity. On the other hand, nanomicelles modified with polysarcosine (PSar), a biocompatible hydrophilic polymer, on their surface have previously achieved rapid tumor uptake, suggesting active transport of PSar into tumor tissues...
February 21, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28165815/effective-improvement-of-the-neuroprotective-activity-after-spinal-cord-injury-by-synergistic-effect-of-glucocorticoid-with-biodegradable-amphipathic-nanomicelles
#19
YueLong Wang, Min Wu, Lei Gu, XiaoLing Li, Jun He, LiangXue Zhou, Aiping Tong, Juan Shi, HongYan Zhu, JianGuo Xu, Gang Guo
Dexamethasone acetate (DA) produces neuroprotective effects by inhibiting lipid peroxidation and inflammation by reducing cytokine release and expression. However, its clinical application is limited by its hydrophobicity, low biocompatibility and numerous side effects when using large dosage. Therefore, improving DA's water solubility, biocompatibility and reducing its side effects are important goals that will improve its clinical utility. The objective of this study is to use a biodegradable polymer as the delivery vehicle for DA to achieve the synergism between inhibiting lipid peroxidation and inflammation effects of the hydrophobic-loaded drugs and the amphipathic delivery vehicle...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28152267/redox-activatable-atp-depleting-micelles-with-dual-modulation-characteristics-for-multidrug-resistant-cancer-therapy
#20
Hebin Wang, Yang Li, Miaozun Zhang, Di Wu, Youqing Shen, Guping Tang, Yuan Ping
A fast adenosine triphosphate (ATP)-depleting micellar system that is activated by intracellular redox for the codelivery of anticancer drug paclitaxel (PTX) and small interference RNA (siRNA) targeting polo-like kinase1 (PLK1) is developed to address the key challenges of multidrug-resistant (MDR) cancer therapy. The ATP-depleting micelle is self-assembled from a redox-responsive amphiphilic polymer (termed as bPEG-SS-P123-PEI (PSPP)) that is composed of biocompatible branched polyethylene glycol (PEG) with 8 arms (bPEG), ATP-depleting Pluronic P123 (P123), and cationic low molecular weight polyethylenimine (PEI) blocks...
April 2017: Advanced Healthcare Materials
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