Christopher M Gabriel, Nicholas R Lee, Florence Bigorne, Piyatida Klumphu, Michael Parmentier, Fabrice Gallou, Bruce H Lipshutz
The impact of varying percentages of an organic solvent added to reactions run in aqueous nanomicelles as the reaction medium has been investigated. Issues such as rates of reaction, percent conversion, and yield, as well as various practical aspects (e.g., effect on stirring, etc.), are discussed, leading to an operationally simple method for the general improvement of potentially problematic systems across a broad range of reaction types, in particular for reactions run at scale.
December 20, 2016: Organic Letters