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Shahrooz Ghaderi, Neda Alidadiani, Jafar Soleimani Rad, Hamid Reza Heidari, Nafi Dilaver, Behzad Mansoori, Reza Rhabarghazi, Rezayat Parvizi, Vahid Khaze Shahgoli, Behzad Baradaran
Purpose: Cardiovascular gene therapy is a sophisticated approach, thanks to the safety of vectors, stable transgene expression, delivery method, and different layers of the heart. To date, numerous expression vectors have been introduced in biotechnology and biopharmacy industries in relation to genetic manipulation. Despite the rapid growth of these modalities, they must be intelligently designed, addressing the cardiac-specific transgene expression and less side effects. Herein, we conducted a pilot project aiming to design a cardiac-specific hypoxia-inducible expression cassette...
March 2018: Advanced Pharmaceutical Bulletin
Tim Schutte, Jelle Tichelaar, Michael O Reumerman, Rike van Eekeren, Robert Rissmann, Cornelis Kramers, Milan C Richir, Eugène P van Puijenbroek, Michiel A van Agtmael
Pharmacovigilance centres monitor the safety of drugs, based on adverse drug reactions (ADRs) reported by doctors, pharmacists and pharmaceutical companies. However, the under-reporting of ADRs remains a major problem. Our aim was to investigate preparedness of future doctors for their role in pharmacovigilance, by assessing their pharmacovigilance awareness, skills and knowledge. The study was a nationwide e-survey among medical students (third to sixth year) of all eight medical schools in the Netherlands...
May 2017: Basic & Clinical Pharmacology & Toxicology
James Jeffrey Bradstreet, Nataliia Sych, Nicola Antonucci, Mariya Klunnik, Olena Ivankova, Irina Matyashchuk, Mariya Demchuk, Dario Siniscalco
Autism spectrum disorders (ASDs) are heterogeneous complex neurodevelopmental pathologies defined by behavioral symptoms, but which have well-characterized genetic, immunological, and physiological comorbidities. Despite extensive research efforts, there are presently no agreed upon therapeutic approaches for either the core behaviors or the associated comorbidities. In particular, the known autoimmune disorders associated with autism are appealing targets for potential stem cell therapeutics. Of the various stem cell populations, fetal stem cells (FSCs) offer the potent immunoregulatory functions found in primordial mesenchymal stem cells, while exhibiting rapid expansion capacity and recognized plasticity...
2014: Cell Transplantation
Yudong Cai, Tao Huang, Lei Chen, Shan Gao, Ning Zhang
No abstract text is available yet for this article.
2014: Computational and Mathematical Methods in Medicine
Yudong Cai, Julio Vera González, Zengrong Liu, Tao Huang
No abstract text is available yet for this article.
2014: BioMed Research International
Xiang-Yang Miao, Xin Zhang
Transgenic animals have potential applications in medicine, life sciences, and biopharmacy. In this study, we developed a convenient, economic, and efficient method for gene transfer by transfection of male spermatogonial stem cells. Three fragments of the Thanatin gene, encoding an antibacterial peptide, were synthesized and amplified by overlap extension polymerase chain reaction (PCR). They were inserted into vector pIRES2-EGFP. The pIRES2-EGFP-Thanatin plasmid was mixed with liposomes and injected into the testes of male mice by a minimally invasive operation...
November 25, 2011: Biochemical and Biophysical Research Communications
K Yoong Lim, Kamila Souckova-Skalicka, Viswambharan Sarasan, James J Clarkson, Mark W Chase, Ales Kovarik, Andrew R Leitch
Polyploids have significantly influenced angiosperm evolution. Understanding the genetic consequences of polyploidy is advanced by studies on synthetic allopolyploids that mimic natural species. In Nicotiana, Burk (1973) and Kostoff (1938) generated synthetic tobacco (N. tabacum) using the parents ♀N. sylvestris × ♂N. tomentosiformis. We previously reported rapid genetic changes in the Burk material. Kostoff's material has 24 chromosomes of N. sylvestris origin (S-genome), 24 of N. tomentosiformis origin (T-genome), and a large intergenomic translocation, but not an additive distribution of ribosomal DNA (rDNA) families as expected from the parental contribution...
June 2006: American Journal of Botany
Frank G A Jansman, An K L Reyners, Eric N van Roon, Carolien H Smorenburg, Helgi H Helgason, Marianne le Comte, Brigit M Wensveen, Annemieke M A van den Tweel, Mieke de Blois, Wilma Kwee, Adrian L Kerremans, Jacobus R B J Brouwers
BACKGROUND: Anticancer drug interactions can affect the efficacy and toxicity of anticancer treatment and that of the interacting drugs. However, information on the significance, prevention, and management of these interactions is currently lacking. OBJECTIVE: The purpose of this study was to assess the clinical significance of interaction among anticancer agents and comedications and to provide recommendations for the management of clinically significant interactions...
March 2011: Clinical Therapeutics
Jørgen Seldrup
Regulatory guidance on the development of drugs has existed for well over half a century in some territories. As drug development grew to become global so was born the need for harmonization. Beginning in the 1990 s, the International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH) developed guidelines which were adopted by the Food and Drug Administration (FDA) in the U.S.A., the European Medicines Agency (EMA) in the European Union and the Pharmaceuticals and Medical Devices Agency (PMDA) in Japan...
June 15, 2011: Statistics in Medicine
Jean-Marie Grouin, Michael Campbell
No abstract text is available yet for this article.
June 15, 2011: Statistics in Medicine
Kevin Braeckmans, Kevin Buyens, Broes Naeye, Dries Vercauteren, Hendrik Deschout, Koen Raemdonck, Katrien Remaut, Niek N Sanders, Jo Demeester, Stefaan C De Smedt
A great deal of attention in biopharmacy and pharmaceutical technology is going to the development of nanoscopic particles to efficiently deliver nucleic acids to target cells. Despite the great potential of nucleic acids for treatment of various diseases, progress in the field is fairly slow. One of the causes is that development of suitable nanoscopic delivery vehicles is hampered by insufficient knowledge of their physicochemical and biophysical properties during the various phases of the transfection process...
November 20, 2010: Journal of Controlled Release: Official Journal of the Controlled Release Society
Yogendra P Singh, Ram A Singh
Garlic has been used medicinally since antiquity because of its antimicrobial activity, anticancer activity, antioxidant activity, ability to reduce cardiovascular diseases, improving immune functions, and antidiabetic activities and also in reducing cardiovascular diseases and improving immune functions. Recent studies identify that the wide variety of medicinal functions are attributed to the sulfur compounds present in garlic. Epidemiological observations and laboratory studies in animal models have also showed anticarcinogenic potential of organosulfur compounds of garlic...
July 2010: BioFactors
J H M Schellens, R Grouls, H J Guchelaar, D J Touw, G A Rongen, A de Boer, L M Van Bortel
Recent position papers addressing the profession of clinical pharmacology have expressed concerns about the decline of interest in the field among clinicians and medical educators in the United Kingdom and other Western countries, whether clinical pharmacology is actually therapeutics, and whether the profession should be limited to physicians. The Dutch Society for Clinical Pharmacology and Biopharmacy offers answers to these questions and presents a new model for clinical pharmacology.
April 2009: Clinical Pharmacology and Therapeutics
E N Anyika, D I Anyika
BACKGROUND: Modern teaching methods require feedback from students in all aspects of the course, examination inclusive. The study is aimed at comparing the perceptions, attitudes and dispositions toward teacher-made essay, multiple-choice and combined (essay with multiple-choice) type examinations currently used to assess students in the Department of Clinical Pharmacy and Biopharmacy of the University of Lagos. METHOD: The survey was conducted in a voluntary captive mode using a sample of 122 penultimate and final year pharmacy students...
January 2008: Nigerian Quarterly Journal of Hospital Medicine
Eszter Ducza, Róbert Gáspár, Attila Mihályi, Zsolt Kormányos, George Falkay
OBJECTIVE: To focus on the possible roles of alpha(1)-adrenergic receptors (alpha(1)-ARs) in rat embryonic implantation. DESIGN: Laboratory study. SETTING: Animal and pharmacology laboratory at Department of Pharmacodynamics and Biopharmacy, University of Szeged, Hungary. ANIMAL(S): Pregnant and nonpregnant Sprague-Dawley rats. INTERVENTION(S): Uterus tissues were collected during the peri-implantation period...
April 2009: Fertility and Sterility
(no author information available yet)
No abstract text is available yet for this article.
December 2005: British Journal of Clinical Pharmacology
Fu-chu He, Jing-hong Wan
In the post-genomic era, with the accomplishment of the sequence mapping of human genome, one of the most important tasks for life science is the explanation and identification of human genome, that is, about 1/3 genes of human genome and their functions need further revealment and verification on the level of protein. In the field of functional proteomics, the human disease proteomics shows great potential in the discovery of new molecular targets and biomarkers for medicine and biopharmacy. In this article, we have made a concise discussion on the current status, existing problems and future development in the research of human disease proteomics both in and out of China...
June 2002: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
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