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lichen myxedematosus

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https://www.readbyqxmd.com/read/27667657/lichen-myxedematosus-diagnostic-criteria-classification-and-severity-grading
#1
Ahmad Nofal, Hala Amer, Rania Alakad, Eman Nofal, Fatma El Desouky, Ayman Yosef, Waleed Albalat, Khaled Gharib, Inass Mostafa, Sahar Fathy, Monira Waked, Eman Ragheb, Hanan Gammaz
BACKGROUND: Lichen myxedematosus (LM) is a rare, chronic idiopathic disorder characterized clinically by waxy, closely set papules, and histopathologically by diffuse dermal mucin deposition and fibroblast proliferation. The most recent classification of LM was proposed in 2001; however, it seems to be complex, confusing, and imprecise. Herein, we present seven cases of LM to evaluate the validity of the current classification, to propose new diagnostic criteria and classification, and to suggest a clinically relevant severity grading system for this rare disorder...
September 25, 2016: International Journal of Dermatology
https://www.readbyqxmd.com/read/27667483/localized-lichen-myxedematosus-in-childhood-what-is-the-accurate-diagnosis
#2
Xiangang Fang, Baoqi Yang, Guizhi Zhou, Furen Zhang
No abstract text is available yet for this article.
September 26, 2016: International Journal of Dermatology
https://www.readbyqxmd.com/read/27617942/mucin-in-the-dermis-a-case-of-tender-tumors
#3
Gina J Ferris, Gina P Spohn, Alejandro Gru, Jessica Kaffenberger
We present an original case report of a 45-year-old woman with a five-month history of sporadic, tender, nodules present on the right upper abdomen, bilateral dorsal wrists, right upper arm, and left flank. Biopsy revealed a mild perivascular infiltrate, increased dermal mucin, and no significant increase in fibroblasts. Presentation and histology were most consistent with nodular lichen myxedematosus (NLM), a rare primary mucinosis. Only four previous cases are reported in the literature to our knowledge. Management of NLM and other subtypes of lichen myxedematosus is not well described...
2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/27422288/atypical-discrete-papular-lichen-myxedematosus-associated-with-monoclonal-gammopathy-report-of-four-cases-and-review-of-the-literature
#4
C Hermans, I Goldscheider, T Ruzicka, F Rongioletti
BACKGROUND: Discrete papular lichen myxedematosus (DPLM) is a rare form of localized lichen myxedematosus that presents with skin involvement only and without systemic involvement. OBJECT: To describe our experience with atypical cases of DPLM associated with monoclonal gammopathy. METHODS: Data were collected from patients with clinicopathological evidence of DPLM associated with monoclonal gammopathy who presented to the Department of Dermatology of two tertiary university-affiliated medical centres from 2000 to 2015 and were followed prospectively...
July 16, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/26955106/lichen-myxedematosus-strict-classification-and-diagnostic-criteria-are-still-lacking
#5
Ahmad Nofal, Rania Alakad, Hala Amer, Eman Nofal
No abstract text is available yet for this article.
January 2016: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/25721845/discrete-acral-nonpapular-localised-lichen-myxedematosus
#6
Jeave Reserva, Rachel Marchalik, Marylee Braniecki
No abstract text is available yet for this article.
2015: BMJ Case Reports
https://www.readbyqxmd.com/read/25243750/nodular-lichen-myxedematosus-during-childhood-a-case-report
#7
Rong Zeng, Min Li, Yiqun Jiang, Weida Liu
Nodular lichen myxedematosus (LM) is a rare disease and is one of the five subtypes of localized LM. It is distinctly characterized by multiple nodules on the trunk and limbs with or without papular lesions. A healthy 6-year-old boy presented with complaints of "knots" on his right chest, upper limb, and thigh for 4 months. To our knowledge this is the first case of nodular LM reported in a child.
November 2014: Pediatric Dermatology
https://www.readbyqxmd.com/read/24656271/acral-persistent-papular-mucinosis-is-it-an-under-diagnosed-disease
#8
REVIEW
Helena Alvarez-Garrido, Laura Najera, Anastasia Alejandra Garrido-Ríos, Suasana Córdoba-Guijarro, María Huerta-Brogeras, Marta Aguado-Lobo, Jesus Borbujo
Acral persistent papular mucinosis is a subtype of localized lichen myxedematosus. It presents as acrally located papules with a benign, but persistent course. It is a scarcely reported disease. We present a female with both the clinical and histopathological described criteria.
March 2014: Dermatology Online Journal
https://www.readbyqxmd.com/read/24527753/scleromyxedema-without-paraproteinemia
#9
Alvaro A Abarzúa, Laura F Giesen, Mauricio O Sandoval, Sergio B González
BACKGROUND: Scleromyxedema is a rare generalized form of lichen myxedematosus, a chronic cutaneous mucinosis of unknown etiology usually associated with a monoclonal gammopathy and underlying systemic disorders. It is characterized by the presence of lichenoid papules and diffuse indurations of the skin. Histologically, mucin deposits are observed in the dermis as variable degrees of fibrosis. Numerous treatment modalities have been reported as producing partial or inconsistent responses associated with significant adverse effects...
August 2014: International Journal of Dermatology
https://www.readbyqxmd.com/read/23364155/successful-intravenous-immunoglobulin-treatment-of-atypical-lichen-myxedematosus-associated-with-hypothyroidism-and-central-nervous-system-involvement-case-report-and-discussion-of-the-literature
#10
REVIEW
Magnus Macnab, Patrick Kenny
BACKGROUND: Lichen myxedematosus (LM) is a rare idiopathic disorder characterized by papules, plaques, and/or nodules in the skin secondary to mucin deposition and variable dermal fibrosis in the absence of thyroid disease. Case reports are the predominant literature on LM due to its rarity, and the data are limited regarding the disease. No standard treatment regimen exists, and the response to treatment varies. OBJECTIVE: This report adds to the limited literature on atypical LM associated with thyroid dysfunction and contributes to the growing body of evidence supporting intravenous immunoglobulin (IVIg) as effective therapy for extensive cases...
January 2013: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/22515222/scleromyxedema-and-the-dermato-neuro-syndrome-case-report-and-review-of-the-literature
#11
REVIEW
Kirsten E Fleming, Divya Virmani, Evelyn Sutton, Richard Langley, Jessica Corbin, Sylvia Pasternak, Noreen M Walsh
Scleromyxedema is a generalized form of lichen myxedematosus which is characterized by a papular and sclerodermoid skin eruption resulting from dermal fibroblast proliferation and mucin deposition. The majority of patients with scleromyxedema have a monoclonal gammopathy, and other systemic manifestations are common. Herein we describe a case of the 'dermato-neuro syndrome', a rare and sometimes fatal neurologic manifestation of scleromyxedema which consists of fever, convulsions and coma, often preceded by a flu-like prodrome...
May 2012: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/21781629/treatment-of-acral-persistent-papular-mucinosis-with-electrocoagulation
#12
Flávia André Jorge, Tatiana Mimura Cortez, Fabiana Guadalini Mendes, Mariângela Esther Alencar Marques, Hélio Amante Miot
BACKGROUND: Acral persistent papular mucinosis is a rare localized form of lichen myxedematosus with few case reports and no documented therapeutic options. OBJECTIVE: To report full resolution of acral persistent papular mucinosis after electrocoagulation. METHODS: Case report of a 51-year-old white female diagnosed with an acral persistent papular mucinosis. The clinical and histopathologic features, treatment provided, and response to treatment are detailed...
July 2011: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/21509202/nodular-type-lichen-myxedematosus-a-case-report
#13
Azusa Ogita, Naoyuki Higashi, Masaru Hosone, Seiji Kawana
An 18-year-old Japanese woman noticed a progressive appearance of nodules on both forearms and on the left cubital fossa and left thigh one year before her initial consultation at our department. Physical examination showed elastic hard, slightly elevated, shiny and yellowish to skin-colored nodules of 6 to 10 mm in size on her extremities. From laboratory and histopathological findings, nodular-type lichen myxedematosus was diagnosed and nodules showed complete remission following local injection of triamcinolone acetonide...
2010: Case Reports in Dermatology
https://www.readbyqxmd.com/read/21122068/acral-persistent-papular-mucinosis-a-case-report-and-literature-review
#14
Di-Qing Luo, Liang-Cai Wu, Jun-Hua Liu, Hai-Yan Zhang
Acral persistent papular mucinosis is a rare subtype of localized lichen myxedematosus. It shows symmetric, asymptomatic, chronic, ivory to flesh-colored, 2-5 mm sized papules arranged on the dorsa of the hands and extensor aspects of the distal forearms. Thirty-two cases including two from China, appear to fit the proposed diagnostic criteria. We report a 31-year-old Chinese woman who presented with papules on the extensor aspects of her hands and distal forearms. Histopathology revealed a circumscribed area in the upper and mid reticular dermis with splaying of collagen fibers caused by amorphous deposits...
May 2011: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/21060774/plaque-like-sclerodermiform-localized-mucinosis-rapidly-responsive-to-topical-tacrolimus
#15
R Schmaltz, T Vogt, C S L Müller
We report the successful treatment of plaque-like sclerodermiform mucinosis using tacrolimus ointment topically. We present a 70-year-old male with a large chronic erythema and hardening of the nuchal skin and shoulder area. Subjective symptoms were a moderate pruritus and a rather disabling stiffness. A biopsy specimen revealed typical features of lichen myxedematosus. In a subsequent clinical examination, no associated illnesses such as hypothyroidism or gammopathy were found. Since no established therapy exists for this condition, and as there was a lack of response to potent topical glucocorticosteroids, tacrolimus 0...
2010: Case Reports in Dermatology
https://www.readbyqxmd.com/read/20827020/generalized-papular-and-sclerodermoid-eruption-scleromyxedema
#16
Zehra Asiran Serdar, Ilknur Kivanc Altunay, Sirin Pekcan Yasar, Gamze Türker Erfan, Pembegül Gunes
Scleromyxedema (SM) is a rare chronic progressive and highly intractable cutaneous disease with unknown etiology, affecting both genders equally between 30 and 50 years. The disease is characterized with mucin deposits in the skin and/or other organs. In fact it is a clinicopathological subset of lichen myxedematosus (LM) according to a new classification. Sclerodermiform plaques and lichenoid papules are characteristic cutaneous lesions. An elevation of IgG λ (lambda) chain exists in most cases and extracutaneous involvement occurring with variable systemic findings is also detected...
September 2010: Indian Journal of Dermatology, Venereology and Leprology
https://www.readbyqxmd.com/read/20464094/-papular-mucinosis-associated-with-hypothyroidism
#17
Morgana Boeno Volpato, Tatiana Jerez Jaime, Martha Pisani Proença, Alexandre Carlos Gripp, Maria de Fátima Guimarães Scotelaro Alves
Papular mucinosis or lichen myxedematosus is an idiopathic disorder characterized by papules, nodules or plaques caused by mucin deposition in the dermis, in the absence of thyroid disease. The present report describes an atypical case with exuberant lesions in the form of plaques, associated with subclinical hypothyroidism. In cutaneous mucinosis, there is an abnormal quantity of mucin in the dermis. In traditional classifications of papular mucinosis, an absence of thyroid disease constitutes a diagnostic criterion...
January 2010: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/20408512/scleromyxedema-presenting-with-neurologic-symptoms-a-case-report-and-review-of-the-literature
#18
REVIEW
Kathleen Marshall, Stacy A Klepeiss, Michael D Ioffreda, Klaus F Helm
Scleromyxedema is a rare variant of lichen myxedematosus. In addition to cutaneous manifestations, scleromyxedema often presents with systemic manifestations, including dysphagia, proximal muscle weakness, central nervous system disturbances, encephalopathy, and restrictive lung disease. It is almost always associated with paraproteinemia, usually IgG with gamma light chains. We review the literature on scleromyxedema associated with neurologic symptoms and present a case of a 49-year-old woman with encephalopathy attributable to scleromyxedema...
March 2010: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/20110223/scleromyxedema-like-syndrome-with-systemic-involvement-in-a-cat
#19
T Müntener, S Rüfenacht, S Di Palma, G Hartmeier, M Welle
Scleromyxedema--the generalized form of lichen myxedematosus, a primary mucinosis--is a rare disease in human patients. It is characterized by dermal mucin deposits, increased numbers of fibroblasts, and variable fibrosis in the absence of thyroid disease. It is accompanied in 80% of cases by a monoclonal gammopathy. To date, scleromyxedema with systemic involvement has not been documented in domestic animals. This is the first report of a scleromyxedema-like syndrome in a cat, which had a substantial deposition of mucin in the dermis of the head and paws with a mild gammaglobulinemia of 2...
March 2010: Veterinary Pathology
https://www.readbyqxmd.com/read/19638067/scleromyxedema-with-an-interstitial-granulomatous-like-pattern-a-rare-histologic-variant-mimicking-granuloma-annulare
#20
Franco Rongioletti, Emanuele Cozzani, Aurora Parodi
Scleromyxedema is the generalized and sclerodermoid form of lichen myxedematosus. Its typical histological features include a diffuse deposition of mucin in the papillary and mid reticular dermis, an increased of collagen deposition, and a proliferation of irregularly arranged fibroblasts. We describe a 76-year-old man presenting with scleromyxedema associated with IgGlambda monoclonal gammopathy whose biopsy showed histological features of an interstitial granulomatous-like process consistent with interstitial granuloma annulare...
October 2010: Journal of Cutaneous Pathology
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