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https://www.readbyqxmd.com/read/28432266/baseline-blood-pressure-effect-on-the-benefit-and-safety-of-intra-arterial-treatment-in-mr-clean-multicenter-randomized-clinical-trial-of-endovascular-treatment-of-acute-ischemic-stroke-in-the-netherlands
#1
Maxim J H L Mulder, Saliha Ergezen, Hester F Lingsma, Olvert A Berkhemer, Puck S S Fransen, Debbie Beumer, Lucie A van den Berg, Geert Lycklama À Nijeholt, Bart J Emmer, H Bart van der Worp, Paul J Nederkoorn, Yvo B W E M Roos, Robert J van Oostenbrugge, Wim H van Zwam, Charles B L M Majoie, Aad van der Lugt, Diederik W J Dippel
BACKGROUND AND PURPOSE: High blood pressure (BP) is associated with poor outcome and the occurrence of symptomatic intracranial hemorrhage in acute ischemic stroke. Whether BP influences the benefit or safety of intra-arterial treatment (IAT) is not known. We aimed to assess the relation of BP with functional outcome, occurrence of symptomatic intracranial hemorrhage and effect of IAT. METHODS: This is a post hoc analysis of the MR CLEAN (Multicenter Randomized Clinical Trial of Endovascular Treatment of Acute Ischemic Stroke in the Netherlands)...
April 21, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28431551/guided-internet-based-versus-face-to-face-clinical-care-in-the-management-of-tinnitus-study-protocol-for-a-multi-centre-randomised-controlled-trial
#2
Eldré W Beukes, David M Baguley, Peter M Allen, Vinaya Manchaiah, Gerhard Andersson
BACKGROUND: Innovative strategies are required to improve access to evidence-based tinnitus interventions. A guided Internet-based cognitive behavioural therapy (iCBT) intervention for tinnitus was therefore developed for a U.K. POPULATION: Initial clinical trials indicated efficacy of iCBT at reducing tinnitus severity and associated comorbidities such as insomnia and depression. The aim of this phase III randomised controlled trial is to compare this new iCBT intervention with an established intervention, namely face-to-face clinical care for tinnitus...
April 21, 2017: Trials
https://www.readbyqxmd.com/read/28431451/-experience-with-the-hind-foot-relaxation-boot
#3
Hans Zwipp, Michael Borrmann, Eberhard Walter
The goal of this paper is to report our experience with hindfoot fractures using our specially developed boot, with a follow-up of 557 cases. This boot works like the well-known Allgöwer-Röck ortheses (ARO), but is a hybrid between a boot and an orthesis. It allows full weightbearing without using crutches and completely protects an acutely operated hind foot fracture, hind foot arthrodesis or a hind foot fracture which is suitable for conservative treatment. In its first generation, this boot was custom made and used in 408 cases, from March 1999 to February 2011...
April 21, 2017: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/28431416/caring-for-critically-injured-children-an-analysis-of-56-pediatric-damage-control-laparotomies
#4
Miguel A Villalobos, Joshua P Hazelton, Rachel L Choron, Lisa Capano-Wehrle, Krystal Hunter, John P Gaughan, Steven E Ross, Mark J Seamon
BACKGROUND: Injury is the leading cause of death in children under 18 years. Damage control principles have been extensively studied in adults but remain relatively unstudied in children. Our primary study objective was to evaluate the use of damage control laparotomy (DCL) in critically injured children. METHODS: An American College of Surgeons-verified Level 1 trauma center review (1996-2013) of pediatric trauma laparotomies was undertaken. Exclusion criteria included: age older than 18 years, laparotomy for abdominal compartment syndrome or delayed longer than 2 hours after admission...
May 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28424496/the-chemical-characterization-of-nigerian-propolis-samples-and-their-activity-against-trypanosoma-brucei
#5
Ruwida Omar, John O Igoli, Tong Zhang, Alexander I Gray, Godwin U Ebiloma, Carol J Clements, James Fearnley, RuAngeli Edrada Ebel, Tim Paget, Harry P de Koning, David G Watson
Profiling of extracts from twelve propolis samples collected from eight regions in Nigeria was carried out using high performance liquid chromatography (LC) coupled with evaporative light scattering (ELSD), ultraviolet detection (UV) and mass spectrometry (MS), gas chromatography mass spectrometry (GC-MS) and nuclear magnetic resonance spectroscopy (NMR). Principal component analysis (PCA) of the processed LC-MS data demonstrated the varying chemical composition of the samples. Most of the samples were active against Trypanosoma b...
April 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28419814/high-intensity-focused-ultrasound-for-treatment-of-symptomatic-benign-thyroid-nodules-a-prospective-study
#6
Brian Hung-Hin Lang, Yu-Cho Woo, Carlos K H Wong
Purpose To evaluate first-year efficacy and changes in pressure symptoms and health-related quality of life (HRQOL) after ultrasonographically (US) guided high-intensity focused ultrasound (HIFU) ablation of symptomatic benign thyroid nodules. Materials and Methods After ethics approval and informed consent were obtained, a prospective trial was conducted. Patients with a symptomatic benign thyroid nodule were given a choice of HIFU treatment or active surveillance. Clinical and US examinations, pressure symptom scores (visual analog scale), and HRQOL questionnaires (short form-12 survey) were evaluated at baseline and at 3, 6, and 12 months...
April 18, 2017: Radiology
https://www.readbyqxmd.com/read/28416584/2-methoxyestradiol-reduces-angiotensin-ii-induced-hypertension-and-renal-dysfunction-in-ovariectomized-female-and-intact-male-mice
#7
Ajeeth K Pingili, Karen N Davidge, Shyamala Thirunavukkarasu, Nayaab S Khan, Akemi Katsurada, Dewan S A Majid, Frank J Gonzalez, L Gabriel Navar, Kafait U Malik
Cytochrome P450 1B1 protects against angiotensin II (Ang II)-induced hypertension and associated cardiovascular changes in female mice, most likely via production of 2-methoxyestradiol. This study was conducted to determine whether 2-methoxyestradiol ameliorates Ang II-induced hypertension, renal dysfunction, and end-organ damage in intact Cyp1b1(-/-), ovariectomized female, and Cyp1b1(+/+) male mice. Ang II or vehicle was infused for 2 weeks and administered concurrently with 2-methoxyestradiol. Mice were placed in metabolic cages on day 12 of Ang II infusion for urine collection for 24 hours...
April 17, 2017: Hypertension
https://www.readbyqxmd.com/read/28415975/k%C3%A4-holo-project-a-protocol-for-a-randomized-controlled-trial-of-a-native-cultural-dance-program-for-cardiovascular-disease-prevention-in-native-hawaiians
#8
Joseph Keawe'aimoku Kaholokula, Mele A Look, Thomas A Wills, Māpuana de Silva, Tricia Mabellos, Todd B Seto, Hyeong Jun Ahn, Ka'imi A Sinclair, Dedra Buchwald
BACKGROUND: As a major risk factor for cardiovascular and cerebrovascular disease (CVD), hypertension affects 33% of U.S. adults. Relative to other US races and ethnicities, Native Hawaiians have a high prevalence of hypertension and are 3 to 4 times more likely to have CVD. Effective, culturally-relevant interventions are needed to address CVD risk in this population. Investigators of the Kā-HOLO Project developed a study design to test the efficacy of an intervention that uses hula, a traditional Hawaiian dance, to increase physical activity and reduce CVD risk...
April 17, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28414680/a-rare-cause-of-abdominal-pain
#9
E M Dauchy, M Modica, N Masri
CASE: A 54 year old woman with hypothyroidism presented with right flank pain that began acutely one week prior to presentation. She was told initially she had a urinary tract infection and treatment resulted in mild symptomatic improvement. The pain returned and she presented to another Emergency Department (ED); and was told the pain was due to constipation. She returned to the ED the next day when her pain worsened and her labs were notable for WBC of 19,000/uL, BUN/Cr of 28/0.75 mg/dL, AST of 31 U/L, ALT of 92 U/L and total bilirubin of 0...
March 2017: Journal of the Louisiana State Medical Society: Official Organ of the Louisiana State Medical Society
https://www.readbyqxmd.com/read/28414675/case-report-of-sarcoidosis-as-a-great-mimicker-in-various-populations
#10
C Bowe, F Jenssen, A Espinoza
INTRODUCTION: The prevalence of sarcoidosis varies as much as 1-40 cases per 100,000 depending on region and population. Sarcoid typically occurs in people younger than 50 years old, with a peak incidence with ages between 20 and 40 years old. African Americans are 3 times more likely to develop sarcoidosis than Caucasian Americans, and woman are more likely than men to develop sarcoidosis in any ethnic group; nonetheless, it remains a valid differential across any population. CASE: A 32 year old Hispanic man presented to the Emergency Department with night sweats, fatigue, and 35 pound unintentional weight loss over the last several weeks...
March 2017: Journal of the Louisiana State Medical Society: Official Organ of the Louisiana State Medical Society
https://www.readbyqxmd.com/read/28414094/effect-of-aging-and-alzheimer-s-disease-like-pathology-on-brain-monoamines-in-mice
#11
C U Von Linstow, M Severino, A Metaxas, J Waider, A A Babcock, K P Lesch, J B Gramsbergen, B Finsen
Aging is the greatest single risk factor of the neurodegenerative disorder Alzheimer's disease (AD). The monoaminergic system, including serotonin (5-HT), dopamine (DA) and noradrenaline (NA) modulates cognition, which is affected in AD. Changes in monoamine levels have been observed in AD, but these can both be age- and/or disease-related. We examined whether brain monoamine levels change as part of physiological aging and/or AD-like disease in APPSWE/PS1ΔE9 (APP/PS1) transgenic mice. The neocortex, hippocampus, striatum, brainstem and cerebellum of 6-, 12-, 18- and 24-month-old B6C3 wild-type (WT) mice and of 18-month old APP/PS1 and WT mice were analysed for 5-HT, DA and NA contents by high-pressured liquid chromatography (HPLC), along with neocortex from 14-month-old APP/PS1 and WT mice...
April 13, 2017: Neurochemistry International
https://www.readbyqxmd.com/read/28411426/thoron-mitigation-system-based-on-charcoal-bed-for-applications-in-thorium-fuel-cycle-facilities-part-2-development-characterization-and-performance-evaluation
#12
K Sudeep Kumara, B K Sahoo, J J Gaware, B K Sapra, Y S Mayya, N Karunakara
Exposure due to thoron ((220)Rn) gas and its decay products in a thorium fuel cycle facility handling thorium or (232)U/(233)U mixture compounds is an important issue of radiological concern requiring control and mitigation. Adsorption in a flow-through charcoal bed offers an excellent method of alleviating the release of (220)Rn into occupational and public domain. In this paper, we present the design, development, and characterization of a Thoron Mitigation System (TMS) for industrial application. Systematic experiments were conducted in the TMS for examining the (220)Rn mitigation characteristics with respect to a host of parameters such as flow rate, pressure drop, charcoal grain size, charcoal mass and bed depth, water content, and heat of the carrier gas...
April 12, 2017: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/28411062/incidence-and-characteristics-of-positive-pressure-ventilation-delivered-to-newborns-in-a-us-tertiary-academic-hospital
#13
Dana E Niles, Courtney Cines, Elena Insley, Elizabeth E Foglia, Okan U Elci, Christiane Skåre, Theresa Olasveengen, Anne Ades, Michael Posencheg, Vinay M Nadkarni, Jo Kramer-Johansen
INTRODUCTION: The Neonatal Resuscitation Program (NRP) guidelines recommend positive pressure ventilation (PPV) in the first 60s of life to support perinatal transition in non-breathing newborns. Our aim was to describe the incidence and characteristics of newborn PPV using real-time observation in the delivery unit. METHODS: Prospective, observational, quality improvement study conducted at a tertiary academic hospital. Deliveries during randomized weekday/evening 8-h shifts were attended by a trained observer...
April 12, 2017: Resuscitation
https://www.readbyqxmd.com/read/28410861/prevalence-of-cardiovascular-health-by-occupation-a-cross-sectional-analysis-among-u-s-workers-aged-%C3%A2-45-years
#14
Leslie A MacDonald, Stephen Bertke, Misty J Hein, Suzanne Judd, Sherry Baron, Robert Merritt, Virginia J Howard
INTRODUCTION: Identification of groups with poor cardiovascular health (CVH) can inform where and how to target public health efforts. National prevalence estimates of CVH were derived for clinical (blood glucose, total cholesterol, blood pressure) and behavioral (BMI, diet quality, physical activity, smoking) factors among U.S. workers aged ≥45 years. METHODS: This cross-sectional analysis included 6,282 employed black and white men and women aged ≥45 years enrolled in the national population-based REasons for Geographic And Racial Differences in Stroke study from 2003 to 2007...
April 5, 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28410092/tidal-volume-delivery-during-the-anesthetic-management-of-neonates-is-variable
#15
Thanaa Abouzeid, Elizabeth J Perkins, Prue M Pereira-Fantini, Anushi Rajapaksa, Asha Suka, David G Tingay
OBJECTIVES: To describe expiratory tidal volume (VT) during routine anesthetic management of neonates at a single tertiary neonatal surgical center, as well as the proportion of VT values within the range of 4.0-8.0?mL/kg. STUDY DESIGN: A total of 26 neonates needing surgery under general anesthesia were studied, of whom 18 were intubated postoperatively. VT was measured continuously during normal clinical care using a dedicated neonatal respiratory function monitor (RFM), with clinicians blinded to values...
March 3, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28409169/the-effectiveness-of-a-peer-coaching-education-on-control-and-management-of-type-2-diabetes-in-women-a-protocol-for-a-randomized-controlled-trial
#16
Maryam Aalaa, Mahnaz Sanjari, Hamid Reza Aghaei Meybodi, Mohammad Reza Amini, Mostafa Qorbani, Hossien Adibi, Neda Mehrdad
BACKGROUND: Diabetes Education by Peer Coaching is a strategy which helps the patients with diabetes in the field of behavioral and emotional problems. However, the results of studies in this field in other countries could not be generalized in our context. So, the current study aimed to examine the effectiveness of Diabetes Education by Peer Coaching on Diabetes Management. METHODS: Outcome variables for patients and peer coaches are measured at baseline and in3,6 and 12 months...
April 2017: International Journal of Community Based Nursing and Midwifery
https://www.readbyqxmd.com/read/28407790/ultrastructure-and-localization-of-neorickettsia-in-adult-digenean-trematodes-provides-novel-insights-into-helminth-endobacteria-interaction
#17
Kerstin Fischer, Vasyl V Tkach, Kurt C Curtis, Peter U Fischer
BACKGROUND: Neorickettsia are a group of intracellular α proteobacteria transmitted by digeneans (Platyhelminthes, Trematoda). These endobacteria can also infect vertebrate hosts of the helminths and cause serious diseases in animals and humans. Neorickettsia have been isolated from infected animals and maintained in cell cultures, and their morphology in mammalian cells has been described. However, limited information is available on the morphology and localization of Neorickettsia in the trematode host...
April 13, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28406485/cardiac-hemodynamics-before-during-and-after-elective-cesarean-section-under-spinal-anesthesia-in-low-risk-women
#18
M Ram, A Lavie, S Lev, Y Blecher, U Amikam, Y Shulman, T Avnon, E Weiner, A Many
OBJECTIVE: The aim of this study was to describe maternal central hemodynamic parameters before and during delivery as well at the early puerperium in healthy women undergoing elective cesarean section (CS) at term. STUDY DESIGN: The noninvasive Cardiac System (NICaS, NI Medical, Petah-Tikva, Israel) is a regional impedance device that measures cardiac output (CO) and its derivatives with a good correlation with the gold standard Swan-Ganz catheter. We performed a prospective longitudinal study of healthy women with a singleton pregnancy at term...
April 13, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/28400308/racial-and-ethnic-differences-in-the-prevalence-of-metabolic-syndrome-and-its-components-of-metabolic-syndrome-in-women-with-polycystic-ovary-syndrome-pcos-a-regional-cross-sectional-study
#19
Jessica L Chan, Sujata Kar, Eszter Vanky, Laure Morin-Papunen, Terhi Piltonen, Johanna Puurunen, Juha S Tapaniennen, Gustavo Arantes Rosa Maciel, Sylvia Asaka Yamashita Hayashida, Jose Maria Saores, Edmund Chada Baracat, Jan Roar Mellembakkam, Anuja Dokras
BACKGROUND: - PCOS is a heterogeneous disorder and its presentation varies with race and ethnicity. Reproductive age women with PCOS are at increased risk of metabolic syndrome however, it is not clear if prevalence of metabolic syndrome and clustering of its components differs based on race and ethnicity. Moreover, the majority of these women do not undergo routine screening for metabolic syndrome. OBJECTIVES: To compare the prevalence of metabolic syndrome and clustering of its components in women with PCOS in the United States with women in India, Brazil, Finland, and Norway...
April 8, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28399624/effect-of-respiratory-muscle-training-on-pulmonary-function-and-aerobic-endurance-in-soccer-players
#20
Tarik Ozmen, Gokce Y Gunes, Ilyas Ucar, Hanife Dogan, Tuba U Gafuroglu
BACKGROUND: Few studies investigated the effects of the respiratory muscle training (RMT) in soccer although exhaustive high intensity exercise is known to lead to muscle fatigue in respiratory muscles. The purpose of this study was to investigate the effect of RMT on pulmonary function and aerobic endurance in soccer players. METHODS: Eighteen male soccer players (mean age 22.2±1.4 years) participated in this study. Participants were assigned randomly to either an RMT or a control (CON) group...
May 2017: Journal of Sports Medicine and Physical Fitness
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