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https://www.readbyqxmd.com/read/28088173/high-risk-human-papillomavirus-infection-and-abnormal-cervical-cytology-among-nepali-and-bhutanese-refugee-women-living-in-eastern-nepal
#1
Madhav P Bhatta, Derek C Johnson, Mingma Lama, Shilu Aryal, Pema Lhaki, Sadeep Shrestha
BACKGROUND: Cervical cancer is the leading cause of cancer morbidity and mortality among women in Nepal and Bhutan. Data on high-risk human papillomavirus (HR-HPV) infection and cervical abnormalities among Nepali and Bhutanese women are sparse. The objectives of this study were to assess and compare the prevalence of HR-HPV infection and cervical abnormalities among Nepali and Bhutanese women living in Jhapa District in eastern Nepal; and examine the risk factors for HR-HPV infection and cervical abnormalities in those women...
January 14, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28088086/design-and-synthesis-of-new-raf-kinase-inhibiting-antiproliferative-quinoline-derivatives-part-2-diarylurea-derivatives
#2
Mohammed I El-Gamal, Mohammad Ashrafuddin Khan, Hamadeh Tarazi, Mohammed S Abdel-Maksoud, Mahmoud M Gamal El-Din, Kyung Ho Yoo, Chang-Hyun Oh
This article describes the design, synthesis, and biological screening of a new series of diarylurea derivatives possessing quinoline nucleus. Nine target compounds were selected by the National Cancer Institute (NCI, Bethesda, Maryland, USA) for in vitro antiproliferative screening against a panel of 58 cancer cell lines of nine cancer types. Following one-dose initial screening, compounds 1d-g and 2b were selected for 5-dose screening in order to calculate their IC50 and total growth inhibition (TGI) values against the cell lines...
January 5, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28078873/fine-needle-aspiration-cytology-of-650-thyroid-nodules-operated-for-multinodular-goiter-a-cyto-histological-correlation-based-on-the-new-italian-cytological-classification-siapec-2014
#3
F Tartaglia, A Giuliani, L Tromba, S Carbotta, M Karpathiotakis, G Tortorelli, F Pelle, R Merola, C Donello, G Carbotta, L De Anna, G Conzo, S Sorrenti, S Ulisse
The new Italian cytological classification (SIAPEC 2014) of thyroid nodules, in line with those of Bethesda and BTA-RCPath, replaces the previous TIR3 class with two new classes (TIR3A and TIR3B), which correspond to different risks of malignancy and clinical actions required. The present study was conducted to evaluate the diagnostic accuracy of the new SIAPEC classification as opposed to its previous version (SIAPEC 2007). Preoperative cytology was compared with the final histology obtained from 650 consecutive patients who underwent total thyroidectomy for multinodular goiter...
October 2016: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28064401/the-national-cancer-institute-r25-cancer-education-grants-program-a-workshop-report
#4
REVIEW
Jeannette F Korczak, Davyd W Chung, Erica Rosemond, Daniel D Von Hoff, Richard L Haspel, John W Waterbor, Shine Chang, Amelie G Ramirez, Susan Perkins, Jonathan Wiest, Ming Lei
Through the R25 Cancer Education Grants Program (CEGP), the National Cancer Institute (NCI) has been supporting the broad educational needs of the cancer research and cancer healthcare communities since 1974. NCI sponsored a workshop on September 13, 2016 in Bethesda, Maryland, with the objectives of sharing best practices in cancer education, communicating R25 CEGP programmatic information, and gathering ideas to strengthen the R25 CEGP to better meet the emerging needs in cancer education in the face of a rapidly changing landscape in cancer research and cancer care...
January 7, 2017: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://www.readbyqxmd.com/read/28052718/thyroid-nodule-size-at-ultrasound-as-a-predictor-of-malignancy-and-final-pathologic-size
#5
Allison Cavallo, Daniel N Johnson, Michael Geoffrey White, Saaduddin Siddiqui, Tatjana Antic, Melvy Mathew, Raymon H Grogan, Peter Angelos, Edwin L Kaplan, Nicole A Cipriani
BACKGROUND: Thyroid-related mortality has remained constant despite increasing incidence of thyroid carcinoma. Most thyroid nodules are benign, therefore, ultrasound and fine needle aspiration (FNA) are integral in cancer screening. We hypothesize that increased nodule size at ultrasound does not predict malignancy and correlation between nodule size at ultrasound and pathologic exam is good. METHODS: Resected thyroids with preoperative ultrasounds were identified...
January 4, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28050940/book-review-evaluation-in-occupational-therapy-obtaining-and-interpreting-data-hinojosa-jim-kramer-paula-eds-2014-evaluation-in-occupational-therapy-obtaining-and-interpreting-data-4th-ed-bethesda-md-aota-press-322-pp-us-98-00-isbn-978-1-56900-356-5
#6
https://www.readbyqxmd.com/read/28050939/book-review-stroke-interventions-to-support-occupational-performance-neurorehabilitation-in-occupational-therapy-series-wolf-timothy-j-ed-2014-stroke-interventions-to-support-occupational-performance-neurorehabilitation-in-occupational-therapy-series-vol-2
#7
https://www.readbyqxmd.com/read/28038733/genetic-mutation-risk-calculation-in-lynch-syndrome-inheritance-evaluating-the-utility-of-the-premm1-2-6-model-in-lyon-the-first-french-study
#8
REVIEW
Souria Aissaoui, Charline Cartellier, Thomas Seytier, Sophie Giraud, Alain Calender
Lynch syndrome is due to germline mutations in mismatch repair genes: MLH1, MSH2, MSH6 and PMS2. It is characterized by an increased risk of various cancers including colorectal and endometrial cancers. Early diagnosis of these patients allows for appropriate surveillance and improves survival rates. Differentiating between patients who should undergo genetic testing and those for whom it is not necessary is difficult despite various established criteria (Amsterdam and Bethesda). Often, health professionals meet in multidisciplinary committees (MDC) to discuss patient cases regarding Lynch syndrome...
December 27, 2016: Bulletin du Cancer
https://www.readbyqxmd.com/read/28028338/cytological-diagnosis-of-pediatric-thyroid-nodule-in-perspective-of-the-bethesda-system-for-reporting-thyroid-cytopathology
#9
Chayanika Pantola, Sanjay Kala, Lubna Khan, Saurabh Pantola, Mahendra Singh, Sumanlata Verma
BACKGROUND: Thyroid nodule is one of the most common endocrinopathies occurring children and adolescents. Though thyroid nodule is rare in the pediatric age group, the rate of malignancy is much higher in this age group compared to adult population. AIM: The objective is to study the application of The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) in pediatric patients and compare the findings with histology. MATERIALS AND METHODS: A total of 218 cases younger than 18 years were studied in a 4-year period from August 2010 to July 2014...
October 2016: Journal of Cytology
https://www.readbyqxmd.com/read/28027167/meeting-the-needs-of-the-nation-for-radiation-protection-summary-of-the-52nd-annual-meeting-of-the-national-council-on-radiation-protection-and-measurements
#10
Richard E Toohey
The 52nd Annual Meeting of the National Council on Radiation Protection and Measurements (NCRP) was held in Bethesda, MD, 11-12 April 2016, on the topic of "Meeting National Needs for Radiation Protection." This meeting was an outgrowth of the NCRP initiative "Where are the Radiation Professionals?" (WARP), which addresses looming shortages in professional personnel trained in the radiological disciplines, including but not limited to health physics, radiological engineering, radiobiology, radiochemistry, radioecology, radiation emergency response; and the medical disciplines of diagnostic and interventional radiology, radiation oncology, nuclear medicine, and medical physics...
February 2017: Health Physics
https://www.readbyqxmd.com/read/28027120/cervical-cancer-screening-of-adolescents-should-not-be-encouraged
#11
Laílca Quirino Henrique, Adriana Bittencourt Campaner, Flavia Salomão dʼAvila
OBJECTIVE: The study aims to assess the frequency of cytological abnormalities in adolescents and young women, to establish the optimum age to start screening. METHODS: A retrospective study of cervical cytology results were obtained from the data center at the Santa Casa Hospital of São Paulo between January 2006 and December 2014, adopting the Bethesda nomenclature system. The cytology exams were divided into 3 groups: group 1-adolescents (10-19 years old); group 2-young women (20-24 years old); and group 3-adults, comprising the remaining cytology exams...
January 2017: Journal of Lower Genital Tract Disease
https://www.readbyqxmd.com/read/27994690/unusual-uptake-of-prostate-specific-tracer-68-ga-psma-hbed-cc-in-a-benign-thyroid-nodule
#12
Nishikant Avinash Damle, Madhavi Tripathi, Partha Sarathi Chakraborty, Manas Kumar Sahoo, Chandrasekhar Bal, Shipra Aggarwal, Geetanjali Arora, Praveen Kumar, Rajeev Kumar, Ravikant Gupta
(68)Ga-Prostate specific membrane antigen- N,N'-bis[2-hydroxy-5-(carboxyethyl)benzyl]ethylenediamine-N,N'-diacetic acid- positron emission tomography/computed tomography or 68 Ga- HBED-CC-PSMA PET/CT, popularly known as PSMA PET/CT, is able to detect a small volume of recurrent prostate carcinoma (PC) when there is a prostate specific antigen (PSA) rise on follow-up after prostatectomy or other definitive treatment for PC. The use of PSMA PET/CT in the initial staging in PC is uncertain at this time. Clinical studies are underway to define its exact role in the management of the disease...
December 2016: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27990589/approach-to-lynch-syndrome-for-the-gastroenterologist
#13
REVIEW
Quan M Bui, David Lin, Wendy Ho
Lynch syndrome is an autosomal-dominant hereditary cancer syndrome. Mutations in mismatch repair genes, including MLH1, MSH2, MSH6, and PMS2, are implicated in the pathogenesis of the syndrome through microsatellite instability (MSI) and a rapid adenoma-carcinoma sequence. The primary methodologies for diagnosis include clinical criteria (Amsterdam I/II, Revised Bethesda Guidelines), computational models, and genetic testing (MSI, immunohistochemistry, germline testing). Universal genetic testing of colorectal cancers has gained popularity as a method to identify high-risk individuals and to offer appropriate cancer surveillance, psychological reassurance, and family planning...
December 18, 2016: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/27989584/comparative-effectiveness-of-new-mechanical-irrigant-agitating-devices-for-debris-removal-from-the-canal-and-isthmus-of-mesial-roots-of-mandibular-molars
#14
Jussaro Alves Duque, Marco Antonio Hungaro Duarte, Lyz Cristina Furquim Canali, Rafaela Fernandes Zancan, Rodrigo Ricci Vivan, Ricardo Affonso Bernardes, Clovis Monteiro Bramante
INTRODUCTION: The aim of this study was to compare the effectiveness of Easy Clean (Easy Dental Equipment, Belo Horizonte, MG, Brazil) in continuous and reciprocating motion, passive ultrasonic irrigation (PUI), Endoactivator systems (Dentsply Maillefer, Ballaigues, Switzerland), and conventional irrigation for debris removal from root canals and isthmus. METHODS: Fifty mesial roots of mandibular molars were embedded in epoxy resin using a metal muffle; afterward, the blocks containing the roots were sectioned at 2, 4, and 6 mm from the apex...
December 15, 2016: Journal of Endodontics
https://www.readbyqxmd.com/read/27988219/dietary-changes-impact-the-gut-microbe-composition-in-overweight-and-obese-men%C3%A2-with-prostate-cancer-undergoing-radical%C3%A2-prostatectomy
#15
Andrew D Frugé, Travis Ptacek, Yuko Tsuruta, Casey D Morrow, Maria Azrad, Renee A Desmond, Gary R Hunter, Soroush Rais-Bahrami, Wendy Demark-Wahnefried
BACKGROUND: Diet and obesity influence prostate cancer risk and progression-effects that may be mediated through the gut microbiome. OBJECTIVE: Our aim was to explore relationships among diet, gut microbes, and Gleason sum in overweight and obese prostate cancer patients enrolled in a presurgical weight-loss trial. DESIGN: Randomized controlled trial (NCT01886677) secondary analysis. PARTICIPANTS/SETTING: In 2013-2014, 40 prostate cancer patients in the southeastern United States were randomized and allocated equally to weight-loss and wait-list control arms while they awaited prostatectomy; stool samples were collected on a subset of 22 patients...
December 14, 2016: Journal of the Academy of Nutrition and Dietetics
https://www.readbyqxmd.com/read/27982447/therapeutic-drug-monitoring-of-posaconazole-oral-suspension-in-paediatric-patients-younger-than-13-years-of-age-a-retrospective-analysis-and-literature-review
#16
T Jancel, P A Shaw, C W Hallahan, T Kim, A F Freeman, S M Holland, S R Penzak
WHAT IS KNOWN AND OBJECTIVE: Posaconazole is an extended-spectrum triazole antifungal with activity against a variety of clinically significant yeasts and moulds. Posaconazole is not currently approved by the U.S. Food and Drug Administration for use in children younger than 13 years of age. Our primary objective was to describe the dosing and observed trough concentrations with posaconazole oral suspension in paediatric patients at the National Institutes of Health Clinical Center (Bethesda, MD)...
February 2017: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/27978562/association-of-malignancy-prevalence-with-test-properties-and-performance-of-the-gene-expression-classifier-in-indeterminate-thyroid-nodules
#17
Zaid Al-Qurayshi, Ahmed Deniwar, Tina Thethi, Tilak Mallik, Sudesh Srivastav, Fadi Murad, Parisha Bhatia, Krzysztof Moroz, Andrew B Sholl, Emad Kandil
Importance: It is crucial for clinicians to know the malignancy prevalence within each indeterminate cytologic category to estimate the performance of the gene expression classifier (GEC). Objective: To examine the variability in the performance of the GEC. Design, Setting, and Participants: This retrospective cohort study of patients with Bethesda category III and IV thyroid nodules used single-institution data from January 1, 2013, through February 29, 2016...
December 15, 2016: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/27928858/carcinoma-of-the-lower-uterine-segment-diagnosed-with-lynch-syndrome-based-on-msh6-germline-mutation-a-case-report
#18
Masataka Adachi, Kouji Banno, Kenta Masuda, Megumi Yanokura, Moito Iijima, Takashi Takeda, Haruko Kunitomi, Yusuke Kobayashi, Wataru Yamagami, Akira Hirasawa, Kaori Kameyama, Kokichi Sugano, Daisuke Aoki
Endometrial cancer in the lower uterine segment (LUS) is associated with Lynch syndrome with MLH1 or MSH2 germline mutation. Here, we report a case of carcinoma of the LUS diagnosed with Lynch syndrome based on MSH6 germline mutation in a 46-year-old woman with abnormal vaginal bleeding. She had had rectal cancer at age 39 with a family history of colon cancer (father, 75 years), pancreatic cancer (paternal grandmother, 74 years), and colon cancer (maternal grandmother, 85 years). Magnetic resonance imaging showed a tumor in the LUS...
December 8, 2016: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/27913858/limitation-of-intraoperative-frozen-section-during-thyroid-surgery
#19
Sandrine Estebe, Cecile Montenat, Adrien Tremoureux, Chloé Rousseau, François Bouilloud, Franck Jegoux
Retrospective analysis on 312 patients, operated for thyroid nodules between 2014 and 2015, was conducted to evaluate the impact of frozen section analysis on the strategy of thyroid nodule surgery. One hundred and ninety-three patients were included. They all underwent preoperative US, fine needle aspiration cytology (FNAC), per operative frozen section (FS) and post operative definitive pathological analysis. Se, Sp, VPP and VPN of FNAC and FS were calculated and compared (McNemar's test). Multivariate analysis was performed to identify independent factor of good results...
December 2, 2016: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/27911001/diagnostic-accuracy-of-thyroid-imaging-reporting-and-data-system-in-the-prediction-of-malignancy-in-nodules-with-atypia-and-follicular-lesion-of-undetermined-significance-cytologies
#20
Husniye Baser, Bekir Cakir, Oya Topaloglu, Afra Alkan, Sefika Burcak Polat, Hayriye Tatli Dogan, Mustafa Omer Yazicioğlu, Cevdet Aydin, Reyhan Ersoy
OBJECTIVE: Thyroid Imaging Reporting and Data System (TIRADS) is a simple and reliable reporting system for the prediction of malignancy. We aimed to determine the role of TIRADS in the prediction of malignancy in subcategories of Bethesda Category III, atypia of undetermined significance (AUS) and follicular lesion of undetermined significance (FLUS). DESIGN & PATIENTS: A total of 461 nodules with AUS cytology in 450 patients and 179 nodules with FLUS cytology in 168 patients were included...
November 7, 2016: Clinical Endocrinology
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