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https://www.readbyqxmd.com/read/29323546/validation-of-the-2015-american-thyroid-association-management-guidelines-for-thyroid-nodules-with-benign-cytologic-findings-in-the-era-of-the-bethesda-system
#1
Yeun-Yoon Kim, Kyunghwa Han, Eun-Kyung Kim, Hee Jung Moon, Jung Hyun Yoon, Vivian Y Park, Jin Young Kwak
OBJECTIVE: The purpose of this study is to investigate follow-up strategies for cytologically benign thyroid nodules according to size and ultrasound (US) pattern according to the 2015 American Thyroid Association (ATA) guidelines in the era of the Bethesda system. MATERIALS AND METHODS: This retrospective study included 1208 patients with 1230 nodules that were cytologically benign at initial fine-needle aspiration performed from June 2012 to December 2014. False-negative rates (FNRs) were calculated by considering nodule size and US pattern according to the 2015 ATA guidelines and were compared between nodules with the high-suspicion US pattern and nodules with the high- or intermediate-suspicion US patterns according to size...
January 11, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29317005/a-quantitative-systematic-review-and-meta-analysis-of-the-effectiveness-of-oral-cholera-vaccine-as-a-reactive-measure-in-cholera-outbreaks
#2
Patricia Schwerdtle, Coretta-Kings Onekon, Katrina Recoche
Introduction The efficacy of oral cholera vaccines (OCVs) in laboratory conditions has been established, and the World Health Organization (WHO; Geneva, Switzerland) has recommended their preventative use in high-risk settings. The WHO recommendation has not been fully operationalized, nor has it been extended to apply to the reactive use of OCVs in real field epidemic conditions due to concerns about potential resource diversion, feasibility, cost, and acceptability. The purpose of this study is to assess and synthesize existing evidence of OCV effectiveness when used reactively in real field conditions...
January 10, 2018: Prehospital and Disaster Medicine
https://www.readbyqxmd.com/read/29301440/advancing-the-understanding-of-progression-in-multiple-sclerosis-an-interview-with-shibeshih-belachew
#3
Shibeshih Belachew
Shibeshih Belachew speaks to Laura Dormer, Commissioning Editor: Dr Shibeshih Belachew, MD, PhD, is a Senior Medical Director for Multiple Sclerosis (MS) Disease Area in Global Product Development Medical Affairs at Roche (Basel, Switzerland). Prior to joining Roche in January 2016, he was Director of MS Franchise and Head of Medical Director's office for Biogen Region Europe and Canada. Previously at Biogen he also served as a Director in Global Neurology for the natalizumab program in Cambridge (MA, USA)...
January 5, 2018: Neurodegenerative Disease Management
https://www.readbyqxmd.com/read/29300866/diagnostic-utility-of-molecular-and-imaging-biomarkers-in-cytological-indeterminate-thyroid-nodules
#4
Elizabeth J de Koster, Lioe-Fee de Geus-Oei, Olaf M Dekkers, Ilse van Engen-van Grunsven, Jaap Hamming, Eleonora P M Corssmit, Hans Morreau, Abbey Schepers, Jan Smit, Wim J G Oyen, Dennis Vriens
Indeterminate thyroid cytology (Bethesda III and IV) corresponds to follicular-patterned benign and malignant lesions, which are particularly difficult to differentiate on cytology alone. As approximately 25% of these nodules harbor malignancy, diagnostic hemithyroidectomy is still custom. However, advanced preoperative diagnostics are rapidly evolving.This review provides an overview of additional molecular and imaging diagnostics for indeterminate thyroid nodules in a pre-operative clinical setting, including considerations regarding cost-effectiveness, availability, and feasibility of combining techniques...
January 2, 2018: Endocrine Reviews
https://www.readbyqxmd.com/read/29289576/botanicals-and-phytochemicals-active-on-cognitive-decline-the-clinical-evidence
#5
REVIEW
Arrigo F G Cicero, Federica Fogacci, Maciej Banach
Beyond the well-known effects on cognitive impairment of the Mediterranean diet, a number of studies have investigated the possible action on cognitive decline of different botanicals and phytochemicals, most of which are well-known anti-inflammatory or antioxidant agents with a good tolerability and safety profile. In particular, the current literature supports the use of Ginkgo biloba, resveratrol, epigallocatechin-3-gallate and l-theanine, Theobroma cacao, Bacopa monnieri, Crocus sativus and curcumin, which might have a positive impact on cognitive impairment used alone or in combination with other nutraceuticals or traditional drugs...
December 28, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29251367/thyroid-fna-diagnostics-in-a-real-life-setting-experiences-of-the-implementation-of-the-bethesda-system-in-finland
#6
I Paajanen, S Metso, P Jaatinen, I Kholová
INTRODUCTION: The Bethesda system is widely accepted for thyroid FNA diagnostics, but has scarcely been analysed in relation to clinical background data. Our aim was to analyse the thyroid FNA diagnostic process in view of clinical data, and to assess the validity of the Bethesda system during the first year of implementation. METHODS: There were 415 thyroid FNAs taken from 363 patients during October 2011-September 2012 in the Pirkanmaa Hospital District, Finland...
December 18, 2017: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/29244995/proceedings-of-the-strategy-meeting-for-the-development-of-an-international-consortium-for-chinese-medicine-and-cancer
#7
Jeffrey D White, Hongsheng Lin, Libin Jia, Roy S Wu, Stephen Lam, Jie Li, Jinhui Dou, Nagi Kumar, Lizhu Lin, Lixing Lao
On November 3, 2014, in Bethesda, MD, the Office of Cancer Complementary and Alternative Medicine of the National Cancer Institute held a meeting to examine the potential utility and feasibility of establishing an international consortium for Chinese medicine and cancer. There is significant interest in the West in using components of Chinese medicine (CM) -such as botanicals and herbal medicines, acupuncture and acupressure, and qigong-in the field of oncology, as potential anticancer agents, for symptom management, and to improve quality of life...
December 2017: Journal of Global Oncology
https://www.readbyqxmd.com/read/29243830/proceedings-of-the-food-and-drug-administration-s-public-workshop-on-new-red-blood-cell-product-regulatory-science-2016
#8
Jaroslav G Vostal, Paul W Buehler, Monique P Gelderman, Abdu I Alayash, Alan Doctor, James C Zimring, Simone A Glynn, John R Hess, Harvey Klein, Jason P Acker, Philip C Spinella, Angelo D'Alessandro, Bernhard Palsson, Thomas J Raife, Michael P Busch, Timothy J McMahon, Marcos Intaglietta, Harold M Swartz, Michael A Dubick, Sylvain Cardin, Rakesh P Patel, Charles Natanson, John W Weisel, Jennifer A Muszynski, Philip J Norris, Paul M Ness
The US Food and Drug Administration (FDA) held a workshop on red blood cell (RBC) product regulatory science on October 6 and 7, 2016, at the Natcher Conference Center on the National Institutes of Health (NIH) Campus in Bethesda, Maryland. The workshop was supported by the National Heart, Lung, and Blood Institute, NIH; the Department of Defense; the Office of the Assistant Secretary for Health, Department of Health and Human Services; and the Center for Biologics Evaluation and Research, FDA. The workshop reviewed the status and scientific basis of the current regulatory framework and the available scientific tools to expand it to evaluate innovative and future RBC transfusion products...
December 15, 2017: Transfusion
https://www.readbyqxmd.com/read/29243180/transoral-thyroidectomy-a-viable-surgical-option-with-unprecedented-complications-a-case-series
#9
S Bakkar, M Al Hyari, M Naghawi, C Corsini, P Miccoli
PURPOSE: To report the clinical implications of an initial experience with transoral endoscopic thyroidectomy vestibular approach (TOETVA). METHODS: From March to November 2017, five cases of TOETVA were performed. Data reported include patient demographics, indication for surgery, extent of surgery, operative time, the need to convert to cervicotomy, the length of hospital stay and post-operative pain and morbidity. Unconventional complications regarded as specific for TOETVA were reported...
December 14, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29240898/natural-history-of-contralateral-nodules-after-lobectomy-in-patients-with-papillary-thyroid-carcinoma
#10
Amit Ritter, Gideon Bachar, Dania Hirsch, Carlos Benbassat, Orna Katz, Nadav Kochen, Talia Diker-Cohen, Amit Akirov, Ilan Shimon, Eyal Robenshtok
Background: Bilateral thyroid nodularity is considered an indication for total thyroidectomy in papillary thyroid carcinoma (PTC) patients. However, the natural history and outcome of contralateral nodules has never been studied. Objective: To investigate the natural history of non-suspicious contralateral nodules after lobectomy for PTC. Methods: We included patients who had ≥1 solid nodules (≥3mm) in the contralateral lobe prior to surgery with benign cytology, or small non suspicious nodules per ultrasound...
December 12, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29239036/a-user-s-guide-to-non-invasive-follicular-thyroid-neoplasm-with-papillary-like-nuclear-features-niftp
#11
REVIEW
Yin P Hung, Justine A Barletta
The term non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) was recently introduced to replace a subset of follicular variant of papillary thyroid carcinoma (FVPTC). The goal of this change was to promote more conservative management of these tumours and spare patients the psychological burden of a cancer diagnosis. The histological diagnosis of NIFTP is stringent: the tumour needs to demonstrate encapsulation or circumscription, a purely follicular architecture and the presence of nuclear features of papillary thyroid carcinoma, while lacking capsular and vascular invasion, a significant component of solid growth and high-grade features (increased mitotic activity and necrosis)...
January 2018: Histopathology
https://www.readbyqxmd.com/read/29225984/acquired-von-willebrand-disease-associated-with-monoclonal-gammopathy-of-unknown-significance
#12
Sijan Basnet, Catherine Lin, Rashmi Dhital, Izza Mir, Elan Mohanty, Biswaraj Tharu, Sushil Ghimire, Dilli Ram Poudel
We present a case of a 79-year-old male who presented with retroperitoneal hematoma a week after motor vehicle accident. Prior history and family history of bleeding were nonsignificant. His activated partial thromboplastin time was found to be prolonged in the emergency department. Further workup with coagulation studies showed decreased factor VIII, vWF antigen, and vWF:ristocetin cofactor assay, and negative Bethesda assay, indicating acquired von Willebrand disease. Immunofluorescence to find an underlying etiology was suggestive of MGUS...
2017: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/29223946/-quality-of-the-exo-endocervical-sampling-in-the-prevention-of-uterine-cervix-cancer
#13
Anabela A Angeleri, Lili B Díaz, Gisela Coliva, Fernando Guerra, Luis A Palaoro, Adriana E Rocher
Cervical and vaginal cytology, Papanicolaou test (PAP), is the most effective test for screening of preneoplastic lesions, and cervical cancer prevention. Its sensitivity goes from 50 to 98%, according to different statistics, and this variation is related to the sampling procedure. A satisfactory smear should be taken from the transformation zone, the junction between endocervix and exocervix. According to Bethesda, metaplastic and/or endocervical cells should be observed under the microscope. The traditional PAP smear includes an exo-endocervical sampling using the Ayre spatula; however, only near 50% of the smears are representative of the transformation zone...
2017: Medicina
https://www.readbyqxmd.com/read/29223193/quality-indicators-for-evaluating-prehospital-emergency-care-a-scoping-review
#14
Ian Howard, Peter Cameron, Lee Wallis, Maaret Castren, Veronica Lindstrom
Introduction Historically, the quality and performance of prehospital emergency care (PEC) has been assessed largely based on surrogate, non-clinical endpoints such as response time intervals or other crude measures of care (eg, stakeholder satisfaction). However, advances in Emergency Medical Services (EMS) systems and services world-wide have seen their scope and reach continue to expand. This has dictated that novel measures of performance be implemented to compliment this growth. Significant progress has been made in this area, largely in the form of the development of evidence-informed quality indicators (QIs) of PEC...
December 10, 2017: Prehospital and Disaster Medicine
https://www.readbyqxmd.com/read/29205261/report-and-research-agenda-of-the-american-geriatrics-society-and-national-institute-on-aging-bedside-to-bench-conference-on-urinary-incontinence-in-older-adults-a-translational-research-agenda-for-a-complex-geriatric-syndrome
#15
Camille P Vaughan, Alayne D Markland, Phillip P Smith, Kathryn L Burgio, George A Kuchel
The American Geriatrics Society, with support from the National Institute on Aging and other funders, held its ninth Bedside-to-Bench research conference, entitled "Urinary Incontinence in the Older Adult: A Translational Research Agenda for a Complex Geriatric Syndrome," October 16 to 18, 2016, in Bethesda, Maryland. As part of a conference series addressing three common geriatric syndromes-delirium, sleep and circadian rhythm disturbance, and urinary incontinence-the series highlighted relationships and pertinent clinical and pathophysiological commonalities between these conditions...
December 4, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29203638/cytokines-in-tendon-disease-a-systematic-review
#16
W Morita, S G Dakin, S J B Snelling, A J Carr
OBJECTIVES: Emerging evidence indicates that tendon disease is an active process with inflammation that is critical to disease onset and progression. However, the key cytokines responsible for driving and sustaining inflammation have not been identified. METHODS: We performed a systematic review of the literature using MEDLINE (U.S. National Library of Medicine, Bethesda, Maryland) in March 2017. Studies reporting the expression of interleukins (ILs), tumour necrosis factor alpha (TNF-α) and interferon gamma in diseased human tendon tissues, and animal models of tendon injury or exercise in comparison with healthy control tissues were included...
December 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/29193910/does-noninvasive-follicular-thyroid-neoplasm-with-papillary-like-nuclear-features-have-distinctive-features-on-sonography
#17
Tamar C Brandler, Joseph Yee, Fang Zhou, Margaret Cho, Joan Cangiarella, Xiao-Jun Wei, Melissa Yee-Chang, Wei Sun
BACKGROUND: The noninvasive encapsulated follicular variant of papillary carcinoma (nEFVPTC) has recently been reclassified to "noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP)," removing this entity from the malignant category. This re-categorization has had major implications for clinical management. NIFTP has overlapping cytohistologic features with papillary thyroid carcinoma (PTC) and with follicular adenomas (FA), but sonographic data comparing NIFTP to PTC and FA is lacking...
November 29, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29193839/implementing-noninvasive-follicular-thyroid-neoplasm-with-papillary-like-nuclear-features-may-potentially-impact-the-risk-of-malignancy-for-thyroid-nodules-categorized-as-aus-flus-and-fn-sfn
#18
Weihong Li, Andrew Sciallis, Madelyn Lew, Judy Pang, Xin Jing
BACKGROUND: Noninvasive encapsulated follicular variant of papillary thyroid carcinoma (PTC) has recently been reclassified as noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP). Implementation of the new terminology may alter the implied risk of malignancy (ROM) across the six categories of The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC). METHODS: The study cohort consisted of thyroid fine needle aspiration (FNA) cases which were assessed between January 2011 and June 2016 and led to surgical resections...
November 30, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29190397/the-international-nucleotide-sequence-database-collaboration
#19
Ilene Karsch-Mizrachi, Toshihisa Takagi, Guy Cochrane
For more than 30 years, the International Nucleotide Sequence Database Collaboration (INSDC; http://www.insdc.org/) has been committed to capturing, preserving and providing access to comprehensive public domain nucleotide sequence and associated metadata which enables discovery in biomedicine, biodiversity and biological sciences. Since 1987, the DNA Data Bank of Japan (DDBJ) at the National Institute for Genetics in Mishima, Japan; the European Nucleotide Archive (ENA) at the European Molecular Biology Laboratory's European Bioinformatics Institute (EMBL-EBI) in Hinxton, UK; and GenBank at National Center for Biotechnology Information (NCBI), National Library of Medicine, National Institutes of Health in Bethesda, Maryland, USA have worked collaboratively to enable access to nucleotide sequence data in standardized formats for the worldwide scientific community...
November 28, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29184699/pancreatic-non-functioning-neuroendocrine-tumor-a-new-entity-genetically-related-to-lynch-syndrome
#20
Anna Serracant Barrera, Sheila Serra Pla, Carmen María Blázquez Maña, Rubén Carrera Salas, Neus García Monforte, Natalia Bejarano González, Andreu Romaguera Monzonis, Francisco Javier Andreu Navarro, Maria Rosa Bella Cueto, Francisco G Borobia
Some pancreatic neuroendocrine tumors (P-NETs) are associated with hereditary syndromes. An association between Lynch syndrome (LS) and P-NETs has been suggested, however it has not been confirmed to date. We describe the first case associating LS and P-NETs. Here we report a 65-year-old woman who in the past 20 years presented two colorectal carcinomas (CRC) endometrial carcinoma (EC), infiltrating ductal breast carcinoma, small intestine adenocarcinoma, two non-functioning P-NETs and sebomatricoma. With the exception of one P-NET, all these conditions were associated with LS, as confirmed by immunohistochemistry (IHC) and polymerase chain reaction (PCR)...
October 2017: Journal of Gastrointestinal Oncology
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