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https://www.readbyqxmd.com/read/29750335/universal-screening-of-both-endometrial-and-colon-cancers-increases-the-detection-of-lynch-syndrome
#1
Tomer Adar, Linda H Rodgers, Kristen M Shannon, Makoto Yoshida, Tianle Ma, Anthony Mattia, Gregory Y Lauwers, Anthony J Iafrate, Nicole M Hartford, Esther Oliva, Daniel C Chung
BACKGROUND: Lynch syndrome (LS) is the most common hereditary cause of colorectal cancer (CRC) and endometrial cancer (EC). Screening of all CRCs for LS is currently recommended, but screening of ECs is inconsistent. The objective of this study was to determine the added value of screening both CRC and EC tumors in the same population. METHODS: A prospective, immunohistochemistry (IHC)-based screening program for all patients with newly diagnosed CRCs and ECs was initiated in 2011 and 2013, respectively, at 2 centers (primary and tertiary)...
May 11, 2018: Cancer
https://www.readbyqxmd.com/read/29746147/female-sex-and-gender-in-lung-sleep-health-and-disease-increased-understanding-of-basic-biological-pathophysiological-and-behavioral-mechanisms-leading-to-better-health-for-female-patients-with-lung-disease
#2
MeiLan K Han, Emilio Arteaga-Solis, John Blenis, Ghada Bourjeily, Deborah J Clegg, Dawn DeMeo, Jeanne Duffy, Ben Gaston, Nicola M Heller, Anna Hemnes, Elizabeth Petri Henske, Raksha Jain, Tim Lahm, Lisa H Lancaster, Joyce Lee, Marianne J Legato, Sherry McKee, Reena Mehra, Alison Morris, Y S Prakash, Martin R Stampfli, Rashmi Gopal-Srivastava, Aaron D Laposky, Antonello Punturieri, Lora Reineck, Xenia Tigno, Janine Clayton
Female sex/gender is an under-characterized variable in studies related to lung development and disease. Notwithstanding, many aspects of lung and sleep biology and pathobiology are impacted by female sex and female reproductive transitions. These may manifest as differential gene expression or peculiar organ development. Some conditions are more prevalent in women, such as asthma and insomnia, or in the case of LAM, are seen almost exclusively in women. In other diseases, presentation differs such as the higher frequency of exacerbations experienced by women with COPD or greater cardiac morbidity among women with sleep disordered breathing...
May 10, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29744655/does-the-acr-ti-rads-scoring-allow-us-to-safely-avoid-unnecessary-thyroid-biopsy-single-center-analysis-in-a-large-cohort
#3
Fatos Dilan Koseoglu Atilla, Basak Ozgen Saydam, Nihat Ali Erarslan, Ayse Gulden Diniz Unlu, Hamiyet Yilmaz Yasar, Muhammet Ozer, Baris Akinci
INTRODUCTION: The American College of Radiology (ACR) has recently proposed a guideline that recommends clinicians to perform thyroid fine-needle aspiration biopsy (FNAB) on the basis of ultrasound features. In this study, we focused on nodules for which no biopsy is recommended by the ACR Thyroid Imaging, Reporting and Data System (TI-RADS) guideline. SUBJECTS AND METHODS: Two-thousand eight-hundred and forty-seven consecutive patients with thyroid nodules who underwent FNAB according to the 2009 American Thyroid Association (ATA) guideline were included...
May 9, 2018: Endocrine
https://www.readbyqxmd.com/read/29744318/evaluation-of-thyroid-lesions-by-fine-needle-aspiration-cytology-according-to-bethesda-system-and-its-histopathological-correlation
#4
Shirish S Nandedkar, Monal Dixit, Kamal Malukani, Amit V Varma, Shankhini Gambhir
Background: The Bethesda system is a uniform reporting system for thyroid cytology that facilitates the clarity of communication among cytopathologists, radiologists, and surgeons and facilitates cytohistologic correlation for thyroid diseases. Objective: This study was carried out to evaluate thyroid lesions by fine-needle aspiration cytology (FNAC) based on Bethesda system of reporting and to correlate the cytological findings with histopathology. Materials and Methods: A total of 606 patients with thyroid lesions were studied by FNAC at our institute between January 1, 2006, and January 31, 2016, and results were compared with histopathology wherever possible...
April 2018: International Journal of Applied and Basic Medical Research
https://www.readbyqxmd.com/read/29738997/ultrasound-requested-by-general-practitioners-or-for-symptoms-unrelated-to-the-thyroid-gland-may-explain-higher-prevalence-of-thyroid-nodules-in-females
#5
Ana Germano, Willian Schmitt, Pedro Almeida, Rui Mateus-Marques, Valeriano Leite
BACKGROUND: A higher prevalence of thyroid nodules/carcinoma in females is well-known from the literature. The reasons for this difference are not fully explained. We intended to assess gender variation in the referral for ultrasound-guided fine needle aspiration (FNA) of thyroid nodules, to study reasons for gender referral differences, and to assess differences in nodules characteristics between genders. METHODS: Included were 272 consecutive patients, with 290 nodules submitted to FNA...
May 3, 2018: Clinical Imaging
https://www.readbyqxmd.com/read/29734520/routine-measurements-of-factor-viii-activity-and-inhibitor-titer-in-the-presence-of-emicizumab-utilizing-anti-idiotype-monoclonal-antibodies
#6
Keiji Nogami, Tetsuhiro Soeda, Tomoko Matsumoto, Yoshiki Kawabe, Takehisa Kitazawa, Midori Shima
BACKGROUND: Emicizumab is an anti-factor (F)IXa/X bispecific monoclonal antibody (mAb), mimicking the Factor (F)VIIIa cofactor activity. Emicizumab does not require activation by thrombin and its shortening effect on the activated partial prothrombin time (aPTT) is more pronounced than that of Factor (F)VIII. aPTT-based FVIII activity (FVIII:C) and FVIII inhibiter titer measurements are influenced by the presence of emicizumab. AIM: To establish a reliable aPTT-based assay to measure FVIII in the presence of emicizumab...
May 7, 2018: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29728850/liquid-based-cytology-do-ancillary-techniques-enhance-detection-of-epithelial-abnormalities
#7
Sridhar Mishra, Nuzhat Husain, Namrata P Awasthi, Yashodhara Pradeep, Roohi Roohi, Sarita Saxena
PURPOSE: Cervical cancer is the fourth most common cancer in women worldwide with very high incidence in India. Liquid-based cytology (LBC) provides the use of ancillary techniques in addition to a good morphology and detection of cytologic abnormalities. The current study was designed to assess the diagnostics of P16INK4a immunoexpression, p16 promoter hypermethylation, human papilloma virus (HPV), and DNA ploidy in LBC samples with cervical precancer and cancer. METHODS: A series of LBC samples categorised by Bethesda system including 22 atypical squamous cells of undetermined significance (ASC-US), 21 low-grade squamous intraepithelial lesion (LSIL), 41 high-grade squamous intraepithelial lesion (HSIL), 54 squamous cell carcinoma (SCC), and 26 controls with normal cytology were included...
May 4, 2018: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29726358/how-advances-in-imaging-will-affect-precision-radiation-oncology
#8
David A Jaffray, Shiva Das, Paula M Jacobs, Robert Jeraj, Philippe Lambin
Radiation oncology is 1 of the most structured disciplines in medicine. It is of a highly technical nature with reliance on robotic systems to deliver intervention, engagement of diverse expertise, and early adoption of digital approaches to optimize and execute the application of this highly effective cancer treatment. As a localized intervention, the dependence on sensitive, specific, and accurate imaging to define the extent of disease, its heterogeneity, and adjacency to normal tissues directly affects the therapeutic ratio...
June 1, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29722175/lack-of-transformation-zone-in-cervical-pap-tests-should-it-be-a-concern-a-quality-assurance-initiative
#9
Evelyn Carolina Polanco Jacome, Jennifer Maerki, Karen Chau, Meredith Akerman, Sujata Sajjan, Melissa Klein, Cecilia Gimenez, Alice Laser, Kasturi Das
BACKGROUND: Bethesda guidelines do not require presence of transformation zone (TZ) for a cervical Pap test to be deemed adequate. However, clinicians are concerned with specimens that are reported to lack TZ. METHODS: We analyzed 566 ThinPrep cases reported as negative for intraepithelial lesion or malignancy (NILM) with no cervical abnormality detected in previous 4 years (2007-2011). These cases were divided into two cohorts; those with TZ (ETZ) and those without TZ (NTZ)...
May 2, 2018: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29714576/unique-burdens-of-pediatric-clinical-trials-in-duchenne-muscular-dystrophy-april-20-21-2017-bethesda-maryland-usa
#10
Timothy Franson, Kathi Kinnett, Timothy P Cripe
Recent increases in the number and breadth of clinical trials for patients with Duchenne muscular dystrophy (DMD) have engendered hope for a better future. Despite the overall enthusiasm by the DMD community for these trials, however, the burdens and pressures that they place on children with Duchenne muscular dystrophy and their families have become painfully apparent. In order to identify, and mediate, these challenges, Parent Project Muscular Dystrophy (PPMD) sponsored a meeting to examine some of these issues more closely in Bethesda, Maryland, on April 20-21, 2017...
January 1, 2018: Therapeutic Innovation & Regulatory Science
https://www.readbyqxmd.com/read/29703794/tirads-score-is-of-limited-clinical-value-for-risk-stratification-of-indeterminate-cytological-results
#11
Emmanuelle Chaigneau, Gilles Russ, Benedicte Royer, Claude Bigorgne, Marie Bienvenu, Agnes Rouxel, Laurence Leenhardt, Lisa Belin, Camille Buffet
CONTEXT: Thyroid nodules with cytological indeterminate results represent a daily and recurrent issue for patient management. OBJECTIVE: The primary aim of our study was to determine if TIRADS (Thyroid Imaging Reporting and Data System) could be used to stratify the malignancy risk of these nodules and to help in their clinical management. Secondary objective was to estimate if this risk stratification would change after reclassification of encapsulated non-invasive follicular variant of papillary carcinomas (FVPTC) as NIFTP...
April 27, 2018: European Journal of Endocrinology
https://www.readbyqxmd.com/read/29702015/interobserver-variability-of-sonographic-features-used-in-the-american-college-of-radiology-thyroid-imaging-reporting-and-data-system
#12
Jenny K Hoang, William D Middleton, Alfredo E Farjat, Sharlene A Teefey, Nicole Abinanti, Fernando J Boschini, Abraham J Bronner, Nirvikar Dahiya, Barbara S Hertzberg, Justin R Newman, Daniel Scanga, Robert C Vogler, Franklin N Tessler
OBJECTIVE: The purpose of this study was to assess interobserver variability in assigning features in the American College of Radiology Thyroid Imaging Reporting and Data System (ACR TI-RADS) lexicon and in making recommendations for thyroid nodule biopsy. MATERIALS AND METHODS: The study cohort comprised 100 nodules in 92 patients who underwent fine-needle aspiration with definitive cytologic results (Bethesda category II or VI) or diagnostic lobectomy between April 2009 and May 2010...
April 27, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29696036/malignancy-rates-in-thyroid-nodules-classified-as-bethesda-categories-iii-and-iv-retrospective-data-from-a-tertiary-center
#13
Beatriz Godoi Cavalheiro, Ana Kober Nogueira Leite, Leandro Luongo de Matos, Aline Palermo Miazaki, Jan Marcel Ientile, Marco Aurelio V Kulcsar, Claudio Roberto Cernea
Background: Thyroid fine needle aspiration (FNA) has a well-established role in the diagnosis of thyroid nodules, and the "Bethesda system for reporting thyroid cytopathology" is used to interpret FNA results. Bethesda categories III and IV encompass varying risks of malignancy. In addition, there is some debate in the literature about how to select among many acceptable treatment approaches. Objectives: To establish an association between these 2 cytological categories and malignancy rates in patients treated in a referral tertiary cancer center, where surgical treatment is recommended for all these patients...
January 2018: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29684254/frequencies-and-malignancy-rates-of-6-tiered-bethesda-categories-of-thyroid-nodules-according-to-ultrasound-assessment-and-nodule-size
#14
Vivian Youngjean Park, Hye Sun Lee, Eun-Kyung Kim, Jin Young Kwak, Jung Hyun Yoon, Hee Jung Moon
BACKGROUND: The malignancy risk of thyroid nodules differs according to Bethesda category, ultrasound features, and nodule size. METHODS: In 2725 thyroid nodules that underwent ultrasound-guided fine-needle aspiration, frequencies and malignancy rates of Bethesda categories were compared according to size and ultrasound assessment. RESULTS: When comparing the ultrasound suspicious nodules ≤10 mm and >10 mm, the frequency of the benign cytology was statistically higher in the >10 mm group, whereas the nondiagnostic and suspicious for malignancy cytology were higher in the ≤10 mm group...
April 23, 2018: Head & Neck
https://www.readbyqxmd.com/read/29668969/liquid-based-cytology-versus-conventional-cytology-for-detection-of-uterine-cervical-lesions-a-prospective-observational-study
#15
Hiroshi Nishio, Takashi Iwata, Hidetaka Nomura, Tohru Morisada, Nobuhiro Takeshima, Hirokuni Takano, Hiroshi Sasaki, Eiji Nakatani, Satoshi Teramukai, Daisuke Aoki
Objective: Liquid-based cytology (LBC) and conventional cytology (CS) are routine diagnostic techniques in cervical cytology, but few studies have compared their diagnostic performances with each other and with histologic diagnosis. This study aimed to compare the diagnostic performances of these techniques in subjects with abnormal cervical cytology of atypical cells of undetermined significance (ASC-US) or worse. Methods: A total of 312 patients diagnosed with ASC-US or worse were enrolled in this prospective study in Japan from 2013 to 2014...
April 13, 2018: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29667044/germline-variants-in-pancreatic-cancer-patients-with-a-personal-or-family-history-of-cancer-fulfilling-the-revised-bethesda-guidelines
#16
Akihiro Ohmoto, Chigusa Morizane, Emi Kubo, Erina Takai, Hiroko Hosoi, Yasunari Sakamoto, Shunsuke Kondo, Hideki Ueno, Kazuaki Shimada, Shinichi Yachida, Takuji Okusaka
BACKGROUND: Pancreatic cancer (PC) is categorized as a neoplasm associated with Lynch syndrome; however, the precise proportion of PC patients harboring DNA mismatch repair genes (MMR genes) remains unclear, especially in the Asian population. METHODS: Among 304 Japanese patients with pathologically proven pancreatic ductal adenocarcinoma, we selected 20 (6.6%) patients with a personal or family history involving first- or second-degree relatives fulfilling the revised Bethesda guidelines (RBG), defined as RBG-compatible cases...
April 17, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29666178/causes-of-death-in-a-contemporary-adult-congenital-heart-disease-cohort
#17
Christopher Yu, Benjamin M Moore, Irina Kotchetkova, Rachael L Cordina, David S Celermajer
OBJECTIVE: The life expectancy of patients with congenital heart disease (CHD) has significantly improved with advances in their paediatric medical care. Mortality patterns are changing as a result. Our study aims to describe survival and causes of death in a contemporary cohort of adult patients with CHD. METHODS: We reviewed 3068 patients in our adult CHD database (age ≥16 years, seen at least once in our centre between 2000 and 2015), and documented the number and causes of death, via Australia's National Death Index...
April 17, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29665745/heterogeneity-in-ppv-of-ras-mutations-in-cytologically-indeterminate-thyroid-nodules
#18
Fadi Nabhan, Kyle Porter, Mark Lupo, Gregory W Randolph, Kepal Narendra Patel, Richard T Kloos
BACKGROUND: RAS mutations are common in the available mutational analysis of cytologically indeterminate (Cyto-I) thyroid nodules. However, their reported positive predictive value (PPV) for cancer is widely variable. The reason for this variability is unknown and it causes clinical management uncertainty. We performed a systematic review evaluating the PPV for cancer in RAS mutation positive Cyto-I nodules and considered variables that might affect residual heterogeneity across the different studies...
April 18, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29643651/pilot-study-of-an-open-source-image-analysis-software-for-automated-screening-of-conventional-cervical-smears
#19
Parikshit Sanyal, Prosenjit Ganguli, Sanghita Barui, Prabal Deb
Introduction: The Pap stained cervical smear is a screening tool for cervical cancer. Commercial systems are used for automated screening of liquid based cervical smears. However, there is no image analysis software used for conventional cervical smears. The aim of this study was to develop and test the diagnostic accuracy of a software for analysis of conventional smears. Materials and Methods: The software was developed using Python programming language and open source libraries...
April 2018: Journal of Cytology
https://www.readbyqxmd.com/read/29626393/cyto-morphologic-spectrum-of-thyroid-lesions-in-children
#20
Priya Pathak, Pooja Sharma, Aditi Daga, Sonal Sharma
INTRODUCTION: Fine needle aspiration (FNA) is routinely used in triaging thyroid lesions in adults. However, role of FNA in pediatric thyroid lesions is less studied. AIM AND OBJECTIVE: To study the cyto-morphologic spectrum of thyroid lesions in pediatric population. MATERIALS AND METHODS: A retrospective analysis (duration-6 years) of thyroid FNA for patients who were 18 years or younger was conducted. The aspirates were classified according to the Bethesda System for Reporting Cytopathology...
April 6, 2018: Diagnostic Cytopathology
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