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trans-cinnamic acid

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https://www.readbyqxmd.com/read/28322849/trans-cinnamic-acid-and-xenorhabdus-szentirmaii-metabolites-synergize-the-potency-of-some-commercial-fungicides
#1
Selcuk Hazir, David I Shapiro-Ilan, Clive H Bock, Luis G Leite
Development of novel approaches for the control of fungal phytopathogens is desirable. In this study we hypothesized that the combination of commercial fungicides with certain enhancing agents could result in synergistic levels of control. Prior research has indicated that trans-cinnamic-acid (TCA), a metabolite of the bacteria Photorhabdus luminescens and metabolites of Xenorhabdus szentirmaii are particularly toxic to various phytpathogenic fungi when compared to metabolites of other Xenorhabdus or Photorhabdus spp...
March 18, 2017: Journal of Invertebrate Pathology
https://www.readbyqxmd.com/read/28301880/fast-and-green-co2-based-extraction-isolation-and-quantification-of-phenolic-styrax-constituents
#2
Johanna Scheuba, Valerie-Katharina Wronski, Judith M Rollinger, Ulrike Grienke
In this study the first supercritical fluid based protocol for the extraction, analysis, and isolation of six polar compounds, i.e., o-vanillin (1), styracin (2), vanillin (3), trans-cinnamic acid (4), vanillic acid (5), and shikimic acid (6), was developed. First, eight styrax resin products (R1-R8) obtained from various Liquidambar tree species, which are known to contain compounds 2-6, were extracted with a 1 : 1 mixture of supercritical CO2 and EtOH. Within 4 minutes, the compounds were successfully baseline separated on an Acquity UPC(2) BEH 2-EP (3...
March 16, 2017: Planta Medica
https://www.readbyqxmd.com/read/28288826/evaluation-of-acute-and-subacute-toxicity-of-hydroethanolic-extract-of-dolichandra-unguis-cati-l-leaves-in-rats
#3
Juliana Calil Brondani, Fernanda Ziegler Reginato, Evelyne da Silva Brum, Marina de Souza Vencato, Cibele Lima Lhamas, Carine Viana Silva, Maria Izabel Ugalde Marques da Rocha, Liliane de Freitas Bauermann, Melânia Palermo Manfron
ETHNOPHARMACOLOGICAL RELEVANCE: Dolichandra unguis-cati L. is a native climbing plant of Brazil, popularly known as "unha de gato". It has been traditionally used mainly as an antipyretic, anti-inflammatory and anti-tumor agent, yet little toxicological information is found in the literature. AIM OF THE STUDY: To identify the chemical composition of the hydroethanolic extract obtained from the leaves of Dolichandra uniguis-cati and to evaluate the acute and subacute toxicity in male and female rats, in order to assess the safety profile of this plant...
March 10, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28231122/phenolic-profiles-and-antioxidant-activity-of-germinated-legumes
#4
Do Tan Khang, Tran Nhan Dung, Abdelnaser Abdelghany Elzaawely, Tran Dang Xuan
Bioactive compounds, which are naturally produced in plants, have been concerned with the food and pharmaceutical industries because of the pharmacological effects on humans. In this study, the individual phenolics of six legumes during germination and antioxidant capacity from sprout extracts were determined. It was found that the phenolic content significantly increased during germination in all legumes. Peanuts showed the strongest antioxidant capacity in both the DPPH• (1,1-diphenyl-2-picrylhydrazyl) method and the reducing power assay (32...
April 9, 2016: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/28213232/analysis-of-flavors-and-fragrances-by-hplc-with-fe3o4-go-magnetic-nanocomposite-as-the-adsorbent
#5
Rui Xiao, Xiaoting Zhang, Xiaona Zhang, Jiahua Niu, Minghua Lu, Xiuhua Liu, Zongwei Cai
In this article, a method for the analysis of flavors and fragrances including ethyl vanillin, trans-cinnamic acid, methyl cinnamate, ethyl cinnamate, and benzyl cinnamate in foods by HPLC with Fe3O4@GO nanocomposite as the adsorbent of magnetic solid-phase extraction was developed. The magnetic Fe3O4@GO nanocomposite was prepared and characterized by transmission electron microscope, infrared spectroscopy, X-ray diffraction and vibrating sample magnetometer. The as-prepared Fe3O4@GO nanocomposite was used as adsorbent for extraction and preconcentration of flavors and fragrances in foods...
May 1, 2017: Talanta
https://www.readbyqxmd.com/read/28171689/collision-induced-dissociation-processes-of-protonated-benzoic-acid-and-related-compounds-competitive-generation-of-protonated-carbon-dioxide-or-protonated-benzene
#6
Sihang Xu, Julius Pavlov, Athula B Attygalle
Upon activation in the gas phase, protonated benzoic acid (m/z 123) undergoes fragmentation by several mechanisms. In addition to the predictable water loss followed by a CO loss, the m/z 123 ion more intriguingly eliminates a molecule of benzene to generate protonated carbon dioxide (HO(+) C≡O, m/z 45), or a molecule of carbon dioxide to yield protonated benzene (m/z 79). Experimental evidence shows that the incipient proton ambulates during the fragmentation processes. For the CO2 or benzene loss, protonated benzoic acid transfers the charge-imparting proton initially to the ortho position and then to the ipso position to generate a transient species which dissociates to form an ion-neutral complex between benzene and protonated CO2 ...
February 7, 2017: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/28107195/a-new-hdac-inhibitor-cinnamoylphenazine-shows-antitumor-activity-in-association-with-intensive-macropinocytosis
#7
Bing-Yan Zhu, Bo-Yang Shang, Yue Du, Yi Li, Liang Li, Xian-Dong Xu, Yong-Su Zhen
Previous studies have shown that intensive macropinocytosis occurs in cancer cells and neutral red (NR) is noted for its capability to enter into the cell massively through a process mimetic to macropinocytosis. In addition, trans-cinnamic acid (tCA) has been found to be an inhibitor of histone deacetylase (HDAC). In the present study, cinnamoylphenazine (CA-PZ) that consists of NR and tCA moieties was synthesized and evaluated. As shown, CA-PZ massively entered into colon carcinoma HT-29 cells and pancreatic carcinoma MIA PaCa-2 cells and this entry was blocked by 5-(N-ethyl-N-isopropyl) amiloride (EIPA, an inhibitor of macropinocytosis), indicating a macropinocytosis-mediated uptake...
January 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28055177/effect-of-genomic-integration-location-on-heterologous-protein-expression-and-metabolic-engineering-in-e-coli
#8
Jacob A Englaender, John Andrew Jones, Brady F Cress, Thomas E Kuhlman, Robert J Linhardt, Mattheos A G Koffas
Chromosomal integration offers a selection-free alternative to DNA plasmids for expression of foreign proteins and metabolic pathways. Episomal plasmid DNA is convenient but has drawbacks including increased metabolic burden and the requirement for selection in the form of antibiotics. E. coli has long been used for the expression of foreign proteins and for the production of valuable metabolites by expression of complete metabolic pathways. The gene encoding the fluorescent reporter protein mCherry was integrated into four genomic loci on the E...
January 5, 2017: ACS Synthetic Biology
https://www.readbyqxmd.com/read/28042675/1%C3%A2-h-nmr-based-metabolomics-study-for-identifying-urinary-biomarkers-and-perturbed-metabolic-pathways-associated-with-severity-of-iga-nephropathy-a-pilot-study
#9
Shiva Kalantari, Mohsen Nafar, Shiva Samavat, Mahmoud Parvin
The severity of IgA nephropathy (IgAN), the most common primary glomerulonephritis, is judged on the basis of histologic and clinical features. A limited number of studies have considered molecular signature of IgAN for this issue and no reliable biomarkers have been presented non-invasively for use in patient evaluations. This study aims to identify metabolite markers excreted in the urine and impaired pathways that are associated with a known marker of severity (proteinuria) to predict mild and severe stages of IgAN...
January 1, 2017: Magnetic Resonance in Chemistry: MRC
https://www.readbyqxmd.com/read/28032317/cinnamomulactone-a-new-butyrolactone-from-the-twigs-of-cinnamomum-cassia-and-its-inhibitory-activity-of-matrix-metalloproteinases
#10
Geum Jin Kim, Jong Yeong Lee, Hyun Gyu Choi, So Young Kim, Eonmi Kim, Sang Hee Shim, Joo-Won Nam, Sang-Hyun Kim, Hyukjae Choi
Cinnamomum cassia (Lauraceae) has long been used as one of the most frequently used traditional oriental medicines for the treatment of gastritis, diabetes, blood circulation disturbance and inflammatory diseases. Cinnamomulactone (1), a new butyrolactone was isolated from the twigs of C. cassia together with nine known compounds, coumarin (2), trans-cinnamic acid (3), cinnamaldehyde (4), 2-hydroxycinnamaldehyde (5), 2-methoxycinnamaldehyde (6), 2-hydroxy-cinnamyl alcohol (7), benzoic acid (8), (+)-syringaresinol (9) and phenethyl (E)-3-[4-methoxyphenyl]-2-propenoate (10)...
December 28, 2016: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/27956861/biochemical-evaluation-of-phenylalanine-ammonia-lyase-from-endemic-plant-cyathobasis-fruticulosa-bunge-aellen-for-the-dietary-treatment-of-phenylketonuria
#11
Seda Şirin, Selcen Babaoğlu Aydaş, Belma Aslım
Enzyme substitution therapy with the phenylalanine ammonia lyase (PAL) is a new approach to the treatment of patients with phenylketonuria (PKU). This enzyme is responsible for the conversion of phenylalanine to trans-cinnamic acid. We assessed the PAL enzyme of the endemic plant Cyathobasis fruticulosa (Bunge) Aellen. for its possible role in the dietary treatment of PKU. The enzyme was found to have a high activity of (64.9±0.1) U/mg, with the optimum pH, temperature and buffer (Tris-HCl and l-phenylalanine) concentration levels of pH=8...
September 2016: Food Technology and Biotechnology
https://www.readbyqxmd.com/read/27914524/the-phenylalanine-ammonia-lyase-gene-family-in-isatis-indigotica-fort-molecular-cloning-characterization-and-expression-analysis
#12
Rui-Fang Ma, Qian-Zi Liu, Ying Xiao, Lei Zhang, Qing Li, Jun Yin, Wan-Sheng Chen
Phenolic compounds, metabolites of the phenylpropanoid pathway, play an important role in the growth and environmental adaptation of many plants. Phenylalanine ammonia-lyase (PAL) is the first key enzyme of the phenylpropanoid pathway. The present study was designed to investigate whether there is a multi-gene family in I. Indigotic and, if so, to characterize their properties. We conducted a comprehensive survey on the transcription profiling database by using tBLASTn analysis. Several bioinformatics methods were employed to perform the prediction of composition and physicochemical characters...
November 2016: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/27837086/cis-cinnamic-acid-is-a-novel-natural-auxin-efflux-inhibitor-that-promotes-lateral-root-formation
#13
Ward Steenackers, Petr Klíma, Mussa Quareshy, Igor Cesarino, Robert P Kumpf, Sander Corneillie, Pedro Araújo, Tom Viaene, Geert Goeminne, Moritz K Nowack, Karin Ljung, Jiří Friml, Joshua J Blakeslee, Ondřej Novák, Eva Zažímalová, Richard Napier, Wout Boerjan, Bartel Vanholme
Auxin steers numerous physiological processes in plants, making the tight control of its endogenous levels and spatiotemporal distribution a necessity. This regulation is achieved by different mechanisms, including auxin biosynthesis, metabolic conversions, degradation, and transport. Here, we introduce cis-cinnamic acid (c-CA) as a novel and unique addition to a small group of endogenous molecules affecting in planta auxin concentrations. c-CA is the photo-isomerization product of the phenylpropanoid pathway intermediate trans-CA (t-CA)...
January 2017: Plant Physiology
https://www.readbyqxmd.com/read/27769938/a-bioactivity-guided-study-on-the-antibacterial-activity-of-hertia-cheirifolia-l-extracts
#14
Kaouther Majouli, Assia Hamdi, Kamel Msaada, Abderraouf Kenani
This study was carried out with the objective to investigate the antibacterial activity of Hertia cheirifolia L. extracts against Gram-positive and Gram-negative strains including Staphylococcus aureus (ATCC 6538), Bacillus subtilis (ATCC 6633), Bacillus licheniformis, Esherichia coli (ATCC 8739), Pseudomonas aeruginosa (ATCC 9027), Salmonella enterica (CIP 8039) and Salmonella typhimirium. The results of this antibacterial screening showed that the ethyl acetate (EtOAc) extracts had the best activity against the tested microorganisms...
October 18, 2016: Microbial Pathogenesis
https://www.readbyqxmd.com/read/27664614/changes-of-phenolic-acids-and-vitamin-e-profiles-on-germinated-rough-rice-oryza-sativa-l-treated-by-high-hydrostatic-pressure
#15
Min Young Kim, Sang Hoon Lee, Gwi Yeong Jang, Meishan Li, Youn Ri Lee, Junsoo Lee, Heon Sang Jeong
This study was performed to investigate changes in the phenolic acid and vitamin E profiles of germinated rough rice following high hydrostatic pressure treatment (HPT). Rough rice was germinated at 37°C for two days and subjected to 0.1, 10, 30, 50, and 100MPa pressures for 24h. The total phenolic acid content increased from 85.37μg/g at 0.1MPa to 183.52μg/g at 100MPa. The highest gallic acid (4.29μg/g), catechin (9.55μg/g), p-coumaric acid (8.36μg/g), ferulic acid (14.99μg/g), salicylic acid (14.88μg/g), naringin (6...
February 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27611576/optimization-of-extraction-conditions-for-maximal-phenolic-flavonoid-and-antioxidant-activity-from-melaleuca-bracteata-leaves-using-the-response-surface-methodology
#16
Wencheng Hou, Wei Zhang, Guode Chen, Yanping Luo
Melaleuca bracteata is a yellow-leaved tree belonging to the Melaleuca genus. Species from this genus are known to be good sources of natural antioxidants, for example, the "tea tree oil" derived from M. alternifolia is used in food processing to extend the shelf life of products. In order to determine whether M. bracteata contains novel natural antioxidants, the components of M. bracteata ethanol extracts were analyzed by gas chromatography-mass spectrometry. Total phenolic and flavonoid contents were extracted and the antioxidant activities of the extracts evaluated...
2016: PloS One
https://www.readbyqxmd.com/read/27498833/phenolic-constituents-from-wissadula-periplocifolia-l-c-presl-and-anti-inflammatory-activity-of-7-4-di-o-methylisoscutellarein
#17
Yanna C F Teles, Jaime Ribeiro-Filho, Patrícia T Bozza, Maria de Fátima Agra, Weam Siheri, John O Igoli, Alexander I Gray, Maria de Fátima V de Souza
This study reports the first phenolics from Wissadula genus (Malvaceae) and the anti-inflammatory activity of 7,4'-di-O-methylisoscutellarein. Using chromatographic methods, five phenolic compounds were isolated from aerial parts of Wissadula periplocifolia (L.) C. Presl. The compounds were identified as 4-hydroxybenzoic acid, 3-hydroxybenzoic acid, trans-cinnamic acid, tamgermanetin and 7,4'-di-O-methylisoscutellarein using spectroscopic methods. The flavone 7,4'-di-O-methylisoscutellarein showed anti-inflammatory activity by inhibiting neutrophils recruitment in a mice model of pleurisy and by decreasing significantly the production of cytokines IL-1β and TNF-α...
August 2016: Natural Product Research
https://www.readbyqxmd.com/read/27473224/desulfotomaculum-aquiferis-sp-nov-and-desulfotomaculum-profundi-sp-nov-isolated-from-a-deep-natural-gas-storage-aquifer
#18
Sabrina Berlendis, Magali Ranchou-Peyruse, Marie-Laure Fardeau, Jean-François Lascourrèges, Manon Joseph, Bernard Ollivier, Thomas Aüllo, David Dequidt, Michel Magot, Anthony Ranchou-Peyruse
Two novel strictly anaerobic bacteria, strains Bs105T and Bs107T, were isolated from a deep aquifer-derived hydrocarbonoclastic community. The cells were rod-shaped, not motile and had terminal spores. Phylogenetic affiliation and physiological properties revealed that these isolates belong to two novel species of the genus Desulfotomaculum. Optimal growth temperatures for strains Bs105T and Bs107T were 42 and 45 °C, respectively. The estimated G+C content of the genomic DNA was 42.9 and 48.7 mol%. For both strains, the major cellular fatty acid was palmitate (C16 : 0)...
November 2016: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/27459036/remarkably-high-homoselectivity-in-2-2-photodimerization-of-trans-cinnamic-acids-in-multicomponent-systems
#19
Thanh Binh Nguyen, Ali Al-Mourabit
[2 + 2] homoadducts were exclusively obtained with total regio- and stereo-selectivities when a suspension of several solid photoactive trans-cinnamic acids in cyclohexane was stirred and irradiated.
September 2016: Photochemical & Photobiological Sciences
https://www.readbyqxmd.com/read/27455682/synthesis-and-characterization-of-thermally-stable-photocurable-polymer-with-cyclohexane-moiety
#20
Dong Mm Kim, Seong Hun Yu, Jun Young Lee
Photocurable polymers with high transparency and thermal stability were synthesized by reaction between a commercial epoxy resin (NC9110) containing cyclohexane moiety and various kinds of cinnamic acids such as trans-cinnamic acid (CA), 3-hydroxy-trans-cinnamic acid (HCA) and 4-methoxy-trans-cinnamic acid (MCA). The photocurable polymers were synthesized with equal equivalent weight ratio of epoxy and cinnamate group. The chemical structures of the synthesized polymers were confirmed by 1H-NMR and FT-IR spectroscopies...
March 2016: Journal of Nanoscience and Nanotechnology
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