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trans-cinnamic acid

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https://www.readbyqxmd.com/read/29417170/in-vitro-anti-pro-oxidant-activities-of-r-ferruginea-extract-and-its-effect-on-glioma-cell-viability-correlation-with-phenolic-compound-content-and-effects-on-membrane-dynamics
#1
Desirée Magalhães Dos Santos, Camila Valesca Jardim Rocha, Elita Ferreira da Silveira, Marcelo Augusto Germani Marinho, Marisa Raquel Rodrigues, Nichole Osti Silva, Ailton da Silva Ferreira, Neusa Fernandes de Moura, Gabriel Jorge Sagrera Darelli, Elizandra Braganhol, Ana Paula Horn, Vânia Rodrigues de Lima
Rapanea ferruginea antioxidant and antitumoral properties were not explored before in literature. This study aimed to investigate these biological activities for the R. ferruginea leaf extract and correlate them with its phenolic content and influence in biological membrane dynamics. Thus, in this study, anti/pro-oxidative properties of R. ferruginea leaf extract by in vitro DPPH and TBARS assays, with respect to the free radical reducing potential and to its activity regarding membrane free radical-induced peroxidation, respectively...
February 8, 2018: Journal of Membrane Biology
https://www.readbyqxmd.com/read/29414866/weed-suppressing-potential-and-isolation-of-potent-plant-growth-inhibitors-from-castanea-crenata-sieb-et-zucc
#2
Phung Thi Tuyen, Tran Dang Xuan, Truong Thi Tu Anh, Truong Mai Van, Ateeque Ahmad, Abdelnaser Abdelghany Elzaawely, Tran Dang Khanh
This study isolated, determined, and quantified plant growth inhibitors in Japanese chestnut (Castanea crenata Sieb. et Zucc), a deciduous species native to Japan and Korea. In laboratory assays, C. crenata leaves showed strong inhibition on germination and seedling growth of Echinochloa crus-galli (barnyardgrass), Lactuca sativa (lettuce), and Raphanus sativus (radish). Laboratory and greenhouse trials showed that leaves of C. crenata appeared as a promising material to manage weeds, especially the dicot weeds...
February 7, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29395579/trans-cinnamic-acid-attenuates-uva-induced-photoaging-through-inhibition-of-ap-1-activation-and-induction-of-nrf2-mediated-antioxidant-genes-in-human-skin-fibroblasts
#3
You-Cheng Hseu, Mallikarjuna Korivi, Fang-Ying Lin, Mei-Ling Li, Ruei-Wan Lin, Jia-Jiuan Wu, Hsin-Ling Yang
BACKGROUND: UVA irradiation-induced skin damage/photoaging is associated with redox imbalance and collagen degradation. OBJECTIVE: Dermato-protective efficacies of trans-cinnamic acid (t-CA), a naturally occurring aromatic compound have been investigated against UVA irradiation, and elucidated underlying molecular mechanism. METHODS: Human foreskin fibroblast-derived (Hs68) cells and nude mice were treated with t-CA prior to UVA exposure, and assayed the anti-photoaging effects of t-CA...
January 27, 2018: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29333387/physicochemical-and-antioxidant-properties-of-honeys-from-the-sundarbans-mangrove-forest-of-bangladesh
#4
M Rabiul Islam, Tahmina Pervin, Hemayet Hossain, Badhan Saha, Sheikh Julfikar Hossain
This study evaluated the physicochemical, nutritional, antioxidant, and phenolic properties of ten honey samples from the Sundarbans mangrove forest, Bangladesh. The average pH, electrical conductivity, total dissolved solid, ash, moisture, hydroxymethyl furfural, titrable acidity, and absorbance were 4.3, 0.38 mS/cm, 187.5 ppm, 0.14%, 17.88%, 4.4 mg/kg, 37.7 meq/kg, and 483 mAU, respectively. In the honeys, the average contents of Ca, Cu, Fe, K, Mg, Mn, and Na were 95.5, 0.19, 6.4, 302, 39.9, 3.4, and 597 ppm, respectively, whereas Cd, Cr, Pb, and Ni were not found...
December 2017: Preventive Nutrition and Food Science
https://www.readbyqxmd.com/read/29287348/evaluation-of-nutritional-and-chemical-composition-of-yacon-syrup-using-1h-nmr-and-uplc-esi-q-tof-mse
#5
Maria de Fátima Gomes da Silva, Ana Paula Dionísio, Fernando Antonio Pinto de Abreu, Edy Sousa de Brito, Nedio Jair Wurlitzer, Lorena Mara Alexandre E Silva, Paulo Riceli Vasconcelos Ribeiro, Sueli Rodrigues, Carlos Alberto Kenji Taniguchi, Dorasilvia Ferreira Pontes
A complete characterization of yacon syrup was performed by analytical techniques, including NMR and UPLC-QTOF-MSE. The effect of the different stages of yacon syrup production on fructooligosaccharides (FOS) and chlorogenic acid (CGA) contents were also evaluated. As a result, in addition to higher levels of FOS and CGA, some mineral elements, such as K, Ca and P, and essential amino acids, such as tryptophan, valine, and threonine, were determined in yacon syrup. Twenty-five compounds were putatively identified, and the main compounds were phenolics derived from quinic and trans-cinnamic acids...
April 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29247336/effects-of-phenolic-compounds-on-growth-of-colletotrichum-spp-in-vitro
#6
Sutapa Roy, Etta Nuckles, Douglas D Archbold
Colletotrichum acutatum is responsible for anthracnose fruit rot, one of the most devastating diseases in strawberry. Phenolic compounds have been described as contributors to anthracnose resistance in strawberry (Fragaria x ananassa, Duch.). Six isolates of Colletotrichum acutatum and four isolates of three other Colletotrichum species, C. gloeosporioides, C. fragariae, and C. graminicola, associated with disease symptoms were investigated in this study. The potential inhibitory effect of phenolic acids (gallic acid, caffeic acid, chlorogenic acid, ferulic acid, trans-cinnamic acid, p-coumaric acid, salicylic acid), flavonoids (catechin, quercetin, naringenin), and ellagic acid, which are naturally found in strawberry, were screened against two different spore suspension concentrations of the Colletotrichum isolates at 5, 10, 50 mM in vitro...
December 15, 2017: Current Microbiology
https://www.readbyqxmd.com/read/29215883/the-conformational-map-of-phenolic-acids
#7
Vanessa Cortijo, Elena R Alonso, Santiago Mata, Jose Luis Alonso
The benefits of vaporization by laser ablation and the high resolution and sensitivity attained by the chirped pulse Fourier transform microwave spectroscopy CP-FTMW have provided the first conformational map of the simplest phenolic acids of trans-cinnamic and p-coumaric. Two conformers of trans-cinnamic acid and four conformers of trans-p-coumaric acid have been characterized under the isolation conditions of a supersonic expansion. The spectroscopic constants derived from the analysis of the rotational spectra compared with those predicted theoretically provide an unmatched means to achieve an unambiguous identification of the observed species...
December 7, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29196539/biochemical-and-structural-analysis-of-substrate-specificity-of-a-phenylalanine-ammonia-lyase
#8
Se-Young Jun, Steven A Sattler, Gabriel S Cortez, Wilfred Vermerris, Scott E Sattler, ChulHee Kang
Phenylalanine ammonia-lyase (PAL) is the first enzyme of the general phenylpropanoid pathway catalyzing the nonoxidative elimination of ammonia from L-phenylalanine to give trans-cinnamate. In monocots, PAL also displays tyrosine ammonia lyase activity (TAL), leading to the formation of p-coumaric acid. The catalytic mechanism and substrate-specificity of a major PAL from Sorghum bicolor (SbPAL1), a strategic plant for bioenergy production, were deduced from crystal structures, molecular docking, site-directed mutagenesis, and kinetic and thermodynamic analyses...
December 1, 2017: Plant Physiology
https://www.readbyqxmd.com/read/29186481/optimisation-of-trans-cinnamic-acid-and-hydrocinnamyl-alcohol-production-with-recombinant-saccharomyces-cerevisiae-and-identification-of-cinnamyl-methyl-ketone-as-a-by-product
#9
Manuela Gottardi, Peter Grün, Helge B Bode, Thomas Hoffmann, Wilfried Schwab, Mislav Oreb, Eckhard Boles
Trans-cinnamic acid (tCA) and hydrocinnamyl alcohol (HcinOH) are valuable aromatic compounds with applications in the flavour, fragrance and cosmetic industry. They can be produced with recombinant yeasts from sugars via phenylalanine after expression of a phenylalanine ammonia lyase (PAL) and an aryl carboxylic acid reductase (ACAR). Here we show that in Saccharomyces cerevisiae a PAL enzyme from the bacterium Photorhabdus luminescens was superior to a previously used plant PAL enzyme for the production of tCA...
November 23, 2017: FEMS Yeast Research
https://www.readbyqxmd.com/read/29057941/cyclobutane-1-3-diacid-cbda-a-semi-rigid-building-block-prepared-by-2-2-photocyclization-for-polymeric-materials
#10
Zhihan Wang, Benjamin Miller, Micah Mabin, Rahul Shahni, Zijun D Wang, Angel Ugrinov, Qianli R Chu
A previously overlooked building block, cyclobutane-1,3-diacid (CBDA), is introduced to materials synthesis due to its great potentials. As an example of CBDA, α-truxillic acid or 2,4-diphenylcyclobutane-1,3-dicarboxylic acid, was readily synthesized from commercially available trans-cinnamic acid. This CBDA showed outstanding stability both in sunlight and upon heating. While its two carboxylic acid groups can be readily utilized in connecting with other molecules to form new materials, the cyclobutane ring was able to tolerate acid and base treatments showing good chemical stability...
October 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28977710/multifaceted-plant-responses-to-circumvent-phe-hyperaccumulation-by-downregulation-of-flux-through-the-shikimate-pathway-and-by-vacuolar-phe-sequestration
#11
Joseph H Lynch, Irina Orlova, Chengsong Zhao, Longyun Guo, Rohit Jaini, Hiroshi Maeda, Tariq Akhtar, Junellie Cruz-Lebron, David Rhodes, John Morgan, Guillaume Pilot, Eran Pichersky, Natalia Dudareva
Detrimental effects of hyperaccumulation of the aromatic amino acid phenylalanine (Phe) in animals, known as phenylketonuria, are mitigated by excretion of Phe derivatives; however, how plants endure Phe accumulating conditions in the absence of an excretion system is currently unknown. To achieve Phe hyperaccumulation in a plant system, we simultaneously decreased in petunia flowers expression of all three Phe ammonia lyase (PAL) isoforms that catalyze the non-oxidative deamination of Phe to trans-cinnamic acid, the committed step for the major pathway of Phe metabolism...
October 4, 2017: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/28953245/potential-use-of-plant-waste-from-the-moth-orchid-phalaenopsis-sogo-yukidian-v3-as-an-antioxidant-source
#12
Truong Ngoc Minh, Phung Thi Tuyen, Do Tan Khang, Nguyen Van Quan, Pham Thi Thu Ha, Nguyen Thanh Quan, Yusuf Andriana, Fan Xinyan, Truong Mai Van, Tran Dang Khanh, Tran Dang Xuan
This research was conducted to exploit the waste of used plant parts from the widely marketed moth orchid cultivar (Phalaenopsis Sogo Yukidian "V3"). Various extracts of roots, stems, and leaves were evaluated for total phenolics, total flavonoids, and antioxidant capacity. The bound extract from stems contained the highest total phenolics (5.092 ± 0.739 mg GAE (gallic acid equivalent)/g DW (dry weight)). The maximum total flavonoids (2.218 ± 0.021 mg RE (rutin equivalent)/g DW) were found in the hexane extract of leaves...
September 27, 2017: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/28870197/polarity-based-characterization-of-biologically-active-extracts-of-ajuga-bracteosa-wall-ex-benth-and-rp-hplc-analysis
#13
Syeda Saniya Zahra, Madiha Ahmed, Muhammad Qasim, Bilquees Gul, Muhammad Zia, Bushra Mirza, Ihsan-Ul Haq
BACKGROUND: The concept of botanical therapeutics has revitalized due to wide importance of plant derived pharmaceuticals. Therefore, the ameliorative characteristics of Ajuga bracteosa were studied. METHODS: Total phenolic content, flavonoid content, antioxidant capacity, reducing power and free-radical scavenging activity were determined colorimetrically. Specific polyphenols were quantified by RP-HPLC analysis. Preliminary cytotoxicity was tested using brine shrimp lethality assay while antiproliferative activity against THP-1 and Hep-G2 cell lines was determined by MTT and SRB protocols respectively...
September 5, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28814712/secondary-compound-hypothesis-revisited-selected-plant-secondary-metabolites-promote-bacterial-degradation-of-cis-1-2-dichloroethylene-cdce
#14
Serena Fraraccio, Michal Strejcek, Iva Dolinova, Tomas Macek, Ondrej Uhlik
Cis-1,2-dichloroethylene (cDCE), which is a common hazardous compound, often accumulates during incomplete reductive dechlorination of higher chlorinated ethenes (CEs) at contaminated sites. Simple monoaromatics, such as toluene and phenol, have been proven to induce biotransformation of cDCE in microbial communities incapable of cDCE degradation in the absence of other carbon sources. The goal of this microcosm-based laboratory study was to discover non-toxic natural monoaromatic secondary plant metabolites (SPMEs) that could enhance cDCE degradation in a similar manner to toluene and phenol...
August 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28801839/biotransformation-with-cellulase-hemicellulase-and-yarrowia-lipolytica-boosts-health-benefits-of-okara
#15
Weng Chan Vong, Xin Ying Lim, Shao-Quan Liu
Okara (soybean residue) is a highly perishable food processing by-product from soymilk and tofu manufacture. It contains a large proportion of insoluble dietary fibre (40-60% on a dry basis), as well as digestion-resistant proteins, trypsin inhibitors and phytic acid. These factors contribute lead to the under-utilisation of okara. To improve the overall nutritional quality of okara, sequential saccharification of okara by Celluclast® 1.5L (cellulase) or Viscozyme® L (cellulase and hemicellulase) and fermentation by the yeast Yarrowia lipolytica were performed...
October 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28769989/synergistic-uric-acid-lowering-effects-of-the-combination-of-chrysanthemum-indicum-linne-flower-and-cinnamomum-cassia-l-j-persl-bark-extracts
#16
Young-Sil Lee, Eunjung Son, Seung-Hyung Kim, Yun Mi Lee, Ohn Soon Kim, Dong-Seon Kim
Chrysanthemum indicum Linne flower (CF) and Cinnamomum cassia (L.) J. Persl bark (CB) extracts have served as the main ingredients in several prescriptions designed to treat hyperuricemia and gout in traditional Chinese and Korean medicine. However, little is known about the combination effects of a CF and CB (CC) mixture on hyperuricemia. In our study, we investigated the antihyperuricemic effects of CC mixture and the mechanisms underlying these effects in normal and potassium oxonate- (PO-) induced hyperuricemic rats...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28763022/characterization-and-expression-profiling-of-camellia-sinensis-cinnamate-4-hydroxylase-genes-in-phenylpropanoid-pathways
#17
Jinxin Xia, Yajun Liu, Shengbo Yao, Ming Li, Mengqing Zhu, Keyi Huang, Liping Gao, Tao Xia
Cinnamate 4-hydroxylase (C4H), a cytochrome P450-dependent monooxygenase, participates in the synthesis of numerous polyphenoid compounds, such as flavonoids and lignins. However, the C4H gene number and function in tea plants are not clear. We screened all available transcriptome and genome databases of tea plants and three C4H genes were identified and named CsC4Ha, CsC4Hb, and CsC4Hc, respectively. Both CsC4Ha and CsC4Hb have 1518-bp open reading frames that encode 505-amino acid proteins. CsC4Hc has a 1635-bp open reading frame that encodes a 544-amino acid protein...
August 1, 2017: Genes
https://www.readbyqxmd.com/read/28746940/comparison-of-the-skin-penetration-of-3-metabolically-stable-chemicals-using-fresh-and-frozen-human-skin
#18
Carine Jacques-Jamin, Hélène Duplan, Helga Rothe, Ophelie Vaillant, Joan Eilstein, Sebastien Grégoire, Richard Cubberley, Daniela Lange, Corie Ellison, Martina Klaric, Nicola Hewitt, Andreas Schepky
BACKGROUND: The Cosmetics Europe ADME Task Force is developing in vitro and in silico tools for predicting skin and systemic concentrations after topical application of cosmetic ingredients. There are conflicting reports as to whether the freezing process affects the penetration of chemicals; therefore, we evaluated whether the storage of human skin used in our studies (8-12 weeks at -20°C) affected the penetration of model chemicals. METHODS: Finite doses of trans-cinnamic acid (TCA), benzoic acid (BA), and 6-methylcoumarin (6MC) (non-volatile, non-protein reactive and metabolically stable in skin) were applied to fresh and thawed frozen skin from the same donors...
2017: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/28719037/efficient-separation-of-high-purity-compounds-from-oxytropis-falcata-using-two-dimensional-preparative-chromatography
#19
Weidong Wang, Yanduo Tao, Lijin Jiao, Minxia Fan, Yun Shao, Qilan Wang, Lijuan Mei, Jun Dang
The separation of high-purity compounds from traditional Tibetan medicines plays an important role in investigating their bioactivity. Nevertheless, it is often quite difficult to isolate compounds with high purity because of the complexity of traditional Tibetan medicines. In this work, an offline two-dimensional reversed-phase preparative method was successfully developed for the separation of high-purity compounds from Oxytropis falcata. Based on the analysis results, an ODS C18 prep column was used for first-dimensional preparation, and 14...
July 18, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28640190/trans-cinnamic-and-chlorogenic-acids-affect-the-secondary-metabolic-profiles-and-ergosterol-biosynthesis-by-fusarium-culmorum-and-f-graminearum-sensu-stricto
#20
Tomasz Kulik, Kinga Stuper-Szablewska, Katarzyna Bilska, Maciej Buśko, Anna Ostrowska-Kołodziejczak, Dariusz Załuski, Juliusz Perkowski
Plant-derived compounds limiting mycotoxin contamination are currently of major interest in food and feed production. However, their potential application requires an evaluation of their effects on fungal secondary metabolism and membrane effects. In this study, different strains of Fusarium culmorum and F. graminearum sensu stricto were exposed to trans-cinnamic and chlorogenic acids on solid YES media. Fusaria produced phenolic acids, whose accumulation was lowered by exogenous phenolic compounds. In addition, fungi reduced exogenous phenolic acids, leading either to their conversion or degradation...
June 22, 2017: Toxins
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