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trans-cinnamic acid

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https://www.readbyqxmd.com/read/28977710/multifaceted-plant-reponses-to-circumvent-phe-hyperaccumulation-by-downregulation-of-flux-through-the-shikimate-pathway-and-by-vacuolar-phe-sequestration
#1
Joseph H Lynch, Irina Orlova, Chengsong Zhao, Longyun Guo, Rohit Jaini, Hiroshi Maeda, Tariq Akhtar, Junellie Cruz-Lebron, David Rhodes, John Morgan, Guillaume Pilot, Eran Pichersky, Natalia Dudareva
Detrimental effects of hyperaccumulation of the aromatic amino acid phenylalanine (Phe) in animals, known as phenylketonuria, are mitigated by excretion of Phe derivatives; however, how plants endure Phe accumulating conditions in the absence of excretion system is currently unknown. To achieve Phe hyperaccumulation in a plant system, we simultaneous decreased in petunia flowers expression of all three Phe ammonia lyase (PAL) isoforms that catalyze the non-oxidative deamination of Phe to trans-cinnamic acid, the committed step for the major pathway of Phe metabolism...
October 4, 2017: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/28953245/potential-use-of-plant-waste-from-the-moth-orchid-phalaenopsis-sogo-yukidian-v3-as-an-antioxidant-source
#2
Truong Ngoc Minh, Phung Thi Tuyen, Do Tan Khang, Nguyen Van Quan, Pham Thi Thu Ha, Nguyen Thanh Quan, Yusuf Andriana, Fan Xinyan, Truong Mai Van, Tran Dang Khanh, Tran Dang Xuan
This research was conducted to exploit the waste of used plant parts from the widely marketed moth orchid cultivar (Phalaenopsis Sogo Yukidian "V3"). Various extracts of roots, stems, and leaves were evaluated for total phenolics, total flavonoids, and antioxidant capacity. The bound extract from stems contained the highest total phenolics (5.092 ± 0.739 mg GAE (gallic acid equivalent)/g DW (dry weight)). The maximum total flavonoids (2.218 ± 0.021 mg RE (rutin equivalent)/g DW) were found in the hexane extract of leaves...
September 27, 2017: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/28870197/polarity-based-characterization-of-biologically-active-extracts-of-ajuga-bracteosa-wall-ex-benth-and-rp-hplc-analysis
#3
Syeda Saniya Zahra, Madiha Ahmed, Muhammad Qasim, Bilquees Gul, Muhammad Zia, Bushra Mirza, Ihsan-Ul Haq
BACKGROUND: The concept of botanical therapeutics has revitalized due to wide importance of plant derived pharmaceuticals. Therefore, the ameliorative characteristics of Ajuga bracteosa were studied. METHODS: Total phenolic content, flavonoid content, antioxidant capacity, reducing power and free-radical scavenging activity were determined colorimetrically. Specific polyphenols were quantified by RP-HPLC analysis. Preliminary cytotoxicity was tested using brine shrimp lethality assay while antiproliferative activity against THP-1 and Hep-G2 cell lines was determined by MTT and SRB protocols respectively...
September 5, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28814712/secondary-compound-hypothesis-revisited-selected-plant-secondary-metabolites-promote-bacterial-degradation-of-cis-1-2-dichloroethylene-cdce
#4
Serena Fraraccio, Michal Strejcek, Iva Dolinova, Tomas Macek, Ondrej Uhlik
Cis-1,2-dichloroethylene (cDCE), which is a common hazardous compound, often accumulates during incomplete reductive dechlorination of higher chlorinated ethenes (CEs) at contaminated sites. Simple monoaromatics, such as toluene and phenol, have been proven to induce biotransformation of cDCE in microbial communities incapable of cDCE degradation in the absence of other carbon sources. The goal of this microcosm-based laboratory study was to discover non-toxic natural monoaromatic secondary plant metabolites (SPMEs) that could enhance cDCE degradation in a similar manner to toluene and phenol...
August 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28801839/biotransformation-with-cellulase-hemicellulase-and-yarrowia-lipolytica-boosts-health-benefits-of-okara
#5
Weng Chan Vong, Xin Ying Lim, Shao-Quan Liu
Okara (soybean residue) is a highly perishable food processing by-product from soymilk and tofu manufacture. It contains a large proportion of insoluble dietary fibre (40-60% on a dry basis), as well as digestion-resistant proteins, trypsin inhibitors and phytic acid. These factors contribute lead to the under-utilisation of okara. To improve the overall nutritional quality of okara, sequential saccharification of okara by Celluclast® 1.5L (cellulase) or Viscozyme® L (cellulase and hemicellulase) and fermentation by the yeast Yarrowia lipolytica were performed...
August 11, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28769989/synergistic-uric-acid-lowering-effects-of-the-combination-of-chrysanthemum-indicum-linne-flower-and-cinnamomum-cassia-l-j-persl-bark-extracts
#6
Young-Sil Lee, Eunjung Son, Seung-Hyung Kim, Yun Mi Lee, Ohn Soon Kim, Dong-Seon Kim
Chrysanthemum indicum Linne flower (CF) and Cinnamomum cassia (L.) J. Persl bark (CB) extracts have served as the main ingredients in several prescriptions designed to treat hyperuricemia and gout in traditional Chinese and Korean medicine. However, little is known about the combination effects of a CF and CB (CC) mixture on hyperuricemia. In our study, we investigated the antihyperuricemic effects of CC mixture and the mechanisms underlying these effects in normal and potassium oxonate- (PO-) induced hyperuricemic rats...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28763022/characterization-and-expression-profiling-of-camellia-sinensis-cinnamate-4-hydroxylase-genes-in-phenylpropanoid-pathways
#7
Jinxin Xia, Yajun Liu, Shengbo Yao, Ming Li, Mengqing Zhu, Keyi Huang, Liping Gao, Tao Xia
Cinnamate 4-hydroxylase (C4H), a cytochrome P450-dependent monooxygenase, participates in the synthesis of numerous polyphenoid compounds, such as flavonoids and lignins. However, the C4H gene number and function in tea plants are not clear. We screened all available transcriptome and genome databases of tea plants and three C4H genes were identified and named CsC4Ha, CsC4Hb, and CsC4Hc, respectively. Both CsC4Ha and CsC4Hb have 1518-bp open reading frames that encode 505-amino acid proteins. CsC4Hc has a 1635-bp open reading frame that encodes a 544-amino acid protein...
August 1, 2017: Genes
https://www.readbyqxmd.com/read/28746940/comparison-of-the-skin-penetration-of-3-metabolically-stable-chemicals-using-fresh-and-frozen-human-skin
#8
Carine Jacques-Jamin, Hélène Duplan, Helga Rothe, Ophelie Vaillant, Joan Eilstein, Sebastien Grégoire, Richard Cubberley, Daniela Lange, Corie Ellison, Martina Klaric, Nicola Hewitt, Andreas Schepky
BACKGROUND: The Cosmetics Europe ADME Task Force is developing in vitro and in silico tools for predicting skin and systemic concentrations after topical application of cosmetic ingredients. There are conflicting reports as to whether the freezing process affects the penetration of chemicals; therefore, we evaluated whether the storage of human skin used in our studies (8-12 weeks at -20°C) affected the penetration of model chemicals. METHODS: Finite doses of trans-cinnamic acid (TCA), benzoic acid (BA), and 6-methylcoumarin (6MC) (non-volatile, non-protein reactive and metabolically stable in skin) were applied to fresh and thawed frozen skin from the same donors...
2017: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/28719037/efficient-separation-of-high-purity-compounds-from-oxytropis-falcata-using-two-dimensional-preparative-chromatography
#9
Weidong Wang, Yanduo Tao, Lijin Jiao, Minxia Fan, Yun Shao, Qilan Wang, Lijuan Mei, Jun Dang
The separation of high-purity compounds from traditional Tibetan medicines plays an important role in investigating their bioactivity. Nevertheless, it is often quite difficult to isolate compounds with high purity because of the complexity of traditional Tibetan medicines. In this work, an offline two-dimensional reversed-phase preparative method was successfully developed for the separation of high-purity compounds from Oxytropis falcata. Based on the analysis results, an ODS C18 prep column was used for first-dimensional preparation, and 14...
July 18, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28640190/trans-cinnamic-and-chlorogenic-acids-affect-the-secondary-metabolic-profiles-and-ergosterol-biosynthesis-by-fusarium-culmorum-and-f-graminearum-sensu-stricto
#10
Tomasz Kulik, Kinga Stuper-Szablewska, Katarzyna Bilska, Maciej Buśko, Anna Ostrowska-Kołodziejczak, Dariusz Załuski, Juliusz Perkowski
Plant-derived compounds limiting mycotoxin contamination are currently of major interest in food and feed production. However, their potential application requires an evaluation of their effects on fungal secondary metabolism and membrane effects. In this study, different strains of Fusarium culmorum and F. graminearum sensu stricto were exposed to trans-cinnamic and chlorogenic acids on solid YES media. Fusaria produced phenolic acids, whose accumulation was lowered by exogenous phenolic compounds. In addition, fungi reduced exogenous phenolic acids, leading either to their conversion or degradation...
June 22, 2017: Toxins
https://www.readbyqxmd.com/read/28631780/tuning-the-photocatalytic-activity-of-bismuth-wolframate-towards-selective-oxidations-for-the-biorefinery-driven-by-solar-light
#11
Rosaria Ciriminna, Riccardo Delisi, Francesco Parrino, Leonardo Palmisano, Mario Pagliaro
The sol-gel entrapment of nanostructured Bi2WO6 enhances the activity and the selectivity of the short-gap semiconductor in the sunlight-driven photo-oxidation of trans-ferulic and trans-cinnamic acid dissolved in water with air as the primary oxidant. Valuable products such as vanillin, benzaldehyde, benzoic acid and vanillic acid are obtained. This provides the proof of concept that photocatalysis could be a promising technology in tomorrow's solar biorefineries.
July 4, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28587992/the-isolation-and-functional-characterization-of-three-liverwort-genes-encoding-cinnamate-4-hydroxylase
#12
Xin-Yan Liu, Hai-Na Yu, Shuai Gao, Yi-Feng Wu, Ai-Xia Cheng, Hong-Xiang Lou
The plant phenylpropanoid pathway is responsible for the synthesis of a wide variety of secondary metabolites. The second step in phenylpropanoid synthesis is carried out by the cytochrome P450 monooxygenase enzyme cinnamate 4-hydroxylase (C4H), which catalyzes the p-hydroxylation of trans-cinnamic acid to p-coumarate. Genes encoding C4H have been characterized in many vascular plant species, but as yet not in any bryophyte species. Here, a survey of the transcriptome sequences of four liverwort species was able to identify eight putative C4Hs...
May 26, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/28567627/endophytic-nocardiopsis-sp-from-zingiber-officinale-with-both-antiphytopathogenic-mechanisms-and-antibiofilm-activity-against-clinical-isolates
#13
Rohini Sabu, K R Soumya, E K Radhakrishnan
Novel and potential antimicrobial compounds are essential to tackle the frequently emerging multidrug-resistant pathogens and also to develop environment friendly agricultural practices. In the current study, endophytic actinomycetes from rhizome of Zingiber officinale were explored in terms of its diversity and bioactive properties. Fourteen different organisms were isolated, identified and screened for activity against Pythium myriotylum and human clinical pathogens. Among these, Nocardiopsis sp. ZoA1 was found to have highest inhibition with excellent antibacterial effects compared to standard antibiotics...
June 2017: 3 Biotech
https://www.readbyqxmd.com/read/28499873/inhibition-of-bioluminescence-in-the-living-gills-of-the-luminous-fungus-mycena-chlorophos-by-trans-4-aminocinnamic-acid
#14
Katsunori Teranishi
The living gills of the fungus Mycena chlorophos spontaneously emit green light. It was previously reported that trans-4-hydroxycinnamic acid and trans-3,4-dihydroxycinnnamic acid are essential for the bright light production in the living gills. However, the chemical mechanisms underlying their bioluminescence are unknown. In the present study, trans-4-aminocinnamic acid was found to inhibit light production in the living gills. The concentrations of trans-4-aminocinnamic acid that inhibited the bioluminescence intensity by 50% of initial values for immature and mature gills were 0...
June 24, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28460312/cinnamoylated-chloroquine-analogues-a-new-structural-class-of-antimalarial-agents
#15
Venkatareddy Gayam, Subban Ravi
A novel series of cinnamoylated chloroquine hybrid analogues were synthesized and evaluated as antimalarial agents. The trans cinnamic acid derivatives (3-8) were synthesized by utilizing substituted aldehydes and malanoic acid in DMF catalysed by DABCO. The final cinnamoylated chloroquine analogues (9-14) were synthesized by utilizing DCC coupling reagent. The amido chloroquine (17) was prepared from acid (16) and compound 2 in benzene using SOCl2 as chlorinating agent. The corresponding ester (15) was prepared from 2-hydroxy acetophenone and 2-bromoacetates in actonitrile in presence of K2CO3 as base followed by basic hydrolysis...
July 28, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28458298/biological-activities-and-antibacterial-biomarker-of-sesbania-grandiflora-bark-extract
#16
Pimporn Anantaworasakul, Hiroshi Hamamoto, Kazuhisa Sekimizu, Siriporn Okonogi
In the present study, the fractionated extracts of Sesbania grandiflora bark were prepared and evaluated for their biological activities. The ethyl acetate fractionate (EAF) showed high antioxidant activity along with free radical scavenging and reducing mechanisms. The free radical scavenging antioxidant activity of EAF was 69.3 ± 3.6% where its Trolox equivalent antioxidant capacity was 13.6 ± 0.7 mM/mg. EAF exhibited the reducing power equivalent to ferrous sulfate at 152 ± 2 mM/mg and equivalent to gallic acid at 1...
May 30, 2017: Drug Discoveries & Therapeutics
https://www.readbyqxmd.com/read/28416882/chemical-composition-antiproliferative-and-antioxidant-activity-of-differently-processed-ganoderma-lucidum-ethanol-extracts
#17
Sonja Veljović, Mile Veljović, Ninoslav Nikićević, Saša Despotović, Siniša Radulović, Miomir Nikšić, Lana Filipović
The content of phenolic compounds (TPC) and glucans, as well as the effectiveness of antiproliferative and antioxidant activity of differently processed Ganoderma lucidum ethanol extracts were determined and compared. The content of glucans (total, α- and β-) strongly depended on the extraction time and particle size, but only interaction of these parameters influenced the TPC. Gallic acid, quercetin, trans-cinnamic acid, kaempferol, hesperetin and naringenin were detected in extracts by HPLC-DAD. The most abundant phenols were hesperetin (1...
April 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28392421/phenylalanine-ammonia-lyase-from-arabidopsis-thaliana-atpal2-a-potent-mio-enzyme-for-the-synthesis-of-non-canonical-aromatic-alpha-amino-acids-part-i-comparative-characterization-to-the-enzymes-from-petroselinum-crispum-pcpal1-and-rhodosporidium-toruloides
#18
Alana Dreßen, Thomas Hilberath, Ursula Mackfeld, Arne Billmeier, Jens Rudat, Martina Pohl
Phenylalanine ammonia lyase (PAL) from Arabidopsis thaliana (AtPAL2) was comparatively characterized to the well-studied enzyme from parsley (PcPAL1) and Rhodosporidium toruloides (RtPAL) with respect to kinetic parameters for the deamination and the amination reaction, pH- and temperature optima and the substrate range of the amination reaction. Whereas both plant enzymes are specific for phenylalanine, the bifunctional enzyme from Rhodosporidium toruloides shows KM-values for L-Phe and L-Tyr in the same order of magnitude and, compared to both plant enzymes, a 10-15-fold higher activity...
April 6, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/28391678/investigation-of-novel-triple-responsive-wormlike-micelles
#19
Mingwei Zhao, Mingwei Gao, Caili Dai, Chenwei Zou, Zhe Yang, Xuepeng Wu, Yifei Liu, Yining Wu, Sisi Fang, Wenjiao Lv
Smart wormlike micelles with stimuli-tunable rheological properties may be useful in a variety of applications, such as in molecular devices and sensors. The formation of triplestimuli-responsive systems so far has been a challenging and important issue. In this work, a novel triplestimuli (photo-, pH-, and thermoresponsive) wormlike micelle is constructed with N-cetyl-N-methylmorpholinium bromide and trans-cinnamic acid (CA). The corresponding multiresponsive behaviors of wormlike micellar system were revealed using cryogenic transmission electron microscopy, a rheometer, and (1)H NMR...
April 20, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28365519/tissue-specific-gene-expression-patterns-of-genes-associated-with-thymol-carvacrol-biosynthesis-in-thyme-thymus-vulgaris-l-and-their-differential-changes-upon-treatment-with-abiotic-elicitors
#20
Mohammad Majdi, Atefe Malekzadeh-Mashhady, Asad Maroufi, Christoph Crocoll
Thyme (Thymus vulgaris L.) is known to produce a variety of phenolic monoterpenes such as thymol and carvacrol. Thymol and carvacrol are health-promoting, biocide and antitoxin compounds and have been considered as the main constituents of essential oils in T. vulgaris. To improve our understanding of the regulation of monoterpene biosynthesis in thyme, the expression of genes related to thymol and carvacrol biosynthesis in different tissues and in response to abiotic elicitors was analyzed. Methyl jasmonate (MeJA), salicylic acid (SA), trans-cinnamic acid (tCA) and UV-C irradiation were applied to T...
June 2017: Plant Physiology and Biochemistry: PPB
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