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trans-cinnamic acid

Rui-Fang Ma, Qian-Zi Liu, Ying Xiao, Lei Zhang, Qing Li, Jun Yin, Wan-Sheng Chen
Phenolic compounds, metabolites of the phenylpropanoid pathway, play an important role in the growth and environmental adaptation of many plants. Phenylalanine ammonia-lyase (PAL) is the first key enzyme of the phenylpropanoid pathway. The present study was designed to investigate whether there is a multi-gene family in I. Indigotic and, if so, to characterize their properties. We conducted a comprehensive survey on the transcription profiling database by using tBLASTn analysis. Several bioinformatics methods were employed to perform the prediction of composition and physicochemical characters...
November 2016: Chinese Journal of Natural Medicines
Ward Jan Steenackers, Petr Klíma, Mussa Quareshy, Igor Cesarino, Robert P Kumpf, Sander Corneillie, Pedro Araújo, Tom Viaene, Geert Goeminne, Moritz K Nowack, Karin Ljung, Jiří Friml, Joshua J Blakeslee, Ondřej Novák, Eva Zažímalová, Richard M Napier, Wout A Boerjan, Bartel Vanholme
Auxin steers numerous physiological processes in plants making the tight control of its endogenous levels and spatiotemporal distribution a necessity. This regulation is achieved by different mechanisms including auxin biosynthesis, metabolic conversions, degradation and transport. Here we introduce cis-cinnamic acid (c-CA) as a novel and unique addition to a small group of endogenous molecules affecting in planta auxin concentrations. c-CA is the photo-isomerization product of the phenylpropanoid pathway intermediate trans-CA (t-CA)...
November 11, 2016: Plant Physiology
Kaouther Majouli, Assia Hamdi, Kamel Msaada, Abderraouf Kenani
This study was carried out with the objective to investigate the antibacterial activity of Hertia cheirifolia L. extracts against Gram-positive and Gram-negative strains including Staphylococcus aureus (ATCC 6538), Bacillus subtilis (ATCC 6633), Bacillus licheniformis, Esherichia coli (ATCC 8739), Pseudomonas aeruginosa (ATCC 9027), Salmonella enterica (CIP 8039) and Salmonella typhimirium. The results of this antibacterial screening showed that the ethyl acetate (EtOAc) extracts had the best activity against the tested microorganisms...
October 18, 2016: Microbial Pathogenesis
Min Young Kim, Sang Hoon Lee, Gwi Yeong Jang, Meishan Li, Youn Ri Lee, Junsoo Lee, Heon Sang Jeong
This study was performed to investigate changes in the phenolic acid and vitamin E profiles of germinated rough rice following high hydrostatic pressure treatment (HPT). Rough rice was germinated at 37°C for two days and subjected to 0.1, 10, 30, 50, and 100MPa pressures for 24h. The total phenolic acid content increased from 85.37μg/g at 0.1MPa to 183.52μg/g at 100MPa. The highest gallic acid (4.29μg/g), catechin (9.55μg/g), p-coumaric acid (8.36μg/g), ferulic acid (14.99μg/g), salicylic acid (14.88μg/g), naringin (6...
February 15, 2017: Food Chemistry
Wencheng Hou, Wei Zhang, Guode Chen, Yanping Luo
Melaleuca bracteata is a yellow-leaved tree belonging to the Melaleuca genus. Species from this genus are known to be good sources of natural antioxidants, for example, the "tea tree oil" derived from M. alternifolia is used in food processing to extend the shelf life of products. In order to determine whether M. bracteata contains novel natural antioxidants, the components of M. bracteata ethanol extracts were analyzed by gas chromatography-mass spectrometry. Total phenolic and flavonoid contents were extracted and the antioxidant activities of the extracts evaluated...
2016: PloS One
Yanna C F Teles, Jaime Ribeiro-Filho, Patrícia T Bozza, Maria de Fátima Agra, Weam Siheri, John O Igoli, Alexander I Gray, Maria de Fátima V de Souza
This study reports the first phenolics from Wissadula genus (Malvaceae) and the anti-inflammatory activity of 7,4'-di-O-methylisoscutellarein. Using chromatographic methods, five phenolic compounds were isolated from aerial parts of Wissadula periplocifolia (L.) C. Presl. The compounds were identified as 4-hydroxybenzoic acid, 3-hydroxybenzoic acid, trans-cinnamic acid, tamgermanetin and 7,4'-di-O-methylisoscutellarein using spectroscopic methods. The flavone 7,4'-di-O-methylisoscutellarein showed anti-inflammatory activity by inhibiting neutrophils recruitment in a mice model of pleurisy and by decreasing significantly the production of cytokines IL-1β and TNF-α...
August 2016: Natural Product Research
Sabrina Berlendis, Magali Ranchou-Peyruse, Marie-Laure Fardeau, Jean-François Lascourrèges, Manon Joseph, Bernard Ollivier, Thomas Aüllo, David Dequidt, Michel Magot, Anthony Ranchou-Peyruse
Two novel strictly anaerobic bacteria, strains Bs105T and Bs107T, were isolated from a deep aquifer-derived hydrocarbonoclastic community. The cells were rod-shaped, not motile and had terminal spores. Phylogenetic affiliation and physiological properties revealed that these isolates belong to two new species of the genus Desulfotomaculum. Optimal growth temperatures for strain Bs105T and Bs107T were 42°C and 45°C, respectively. The estimated G+C content of the genomic DNA was 42.9% and 48.7%. For both strains, the major cellular fatty acid was palmitate (C16:0)...
July 28, 2016: International Journal of Systematic and Evolutionary Microbiology
Thanh Binh Nguyen, Ali Al-Mourabit
[2 + 2] homoadducts were exclusively obtained with total regio- and stereo-selectivities when a suspension of several solid photoactive trans-cinnamic acids in cyclohexane was stirred and irradiated.
September 2016: Photochemical & Photobiological Sciences
Dong Mm Kim, Seong Hun Yu, Jun Young Lee
Photocurable polymers with high transparency and thermal stability were synthesized by reaction between a commercial epoxy resin (NC9110) containing cyclohexane moiety and various kinds of cinnamic acids such as trans-cinnamic acid (CA), 3-hydroxy-trans-cinnamic acid (HCA) and 4-methoxy-trans-cinnamic acid (MCA). The photocurable polymers were synthesized with equal equivalent weight ratio of epoxy and cinnamate group. The chemical structures of the synthesized polymers were confirmed by 1H-NMR and FT-IR spectroscopies...
March 2016: Journal of Nanoscience and Nanotechnology
Ryosuke Fujiwara, Shuhei Noda, Tsutomu Tanaka, Akihiko Kondo
To produce styrene from a biomass-derived carbon source, Streptomyces lividans was adopted as a host strain. The gene encoding ferulic acid decarboxylase from Saccharomyces cerevisiae (FDC1) was introduced into S. lividans, and the resulting S. lividans transformant successfully expressed FDC1 and converted trans-cinnamic acid (CA) to styrene. A key factor in styrene production using microbes is the recovery of volatile styrene. In the present study, we selected polystyrene resin beads XRD-4 as the absorbent agent to recover styrene produced using S...
July 9, 2016: Journal of Bioscience and Bioengineering
Amel Bouzidi, Anissa Benzarti, Amira El Arem, Adel Mahfoudhi, Saoussen Hammami, Mohamed Gorcii, Maha Mastouri, Ahmed Noureddine Hellal, Zine Mighri
In the present investigation, extracts obtained from L. guyonianum Durieu ex Boiss. aerial parts were used to evaluate total phenolic, flavonoid and tannin contents. A study of antioxidant activities of the prepared samples was carried out on the basis of 1,1-Diphenyl-2-picrylhydrazyl (DPPH), 2-2'-azino-bis-(3-ethylbenz-thiazoline-6-sulfonic acid) (ABTS+.) and ferric reducing antioxidant power (FRAP) assays. Moreover, the efficiency of methanolic, chloroformic and petroleum ether extracts and the deriving fractions from the methanolic extract was tested against human bacterial and fungal pathogenic strains using micro dilution method in 96 multiwell microtiter plate...
July 2016: Pakistan Journal of Pharmaceutical Sciences
Jang-bo He, Jing Jia, Hong-ping Gou, Xue-mei Zhang, Xi-song Miao, Fang He, Jian Tao
OBJECTIVE: To study the chemical constituents of Cynanchum auriculatum. METHODS: Nine compounds were isolated by silica gel, RP-18 column chromatography and Sephadex LH20. RESULTS: Nine compounds were isolated from the ethanol extract of Cynanchum auriculatum. Their structures were determined as sarcosin-3-O-β-cymaropyranoside (1), cynotophylloside B (2), clemaphenol A (3), deacetylmetaplexigenin (4), methyl-2,6-dideoxy-3-O-methyl-β-D-arabino-hexopyranosyl- (1 --> 4) -6-deoxy-3-O-methyl-α-L-ribo-hexopyranoside (5), trans-p-hydroxy cinnamic methyl ester (6), cyclo(D-Pro-D-Leu) (7), 3α-hydroxy-5α ,6α-epoxy-7-megastigmen9-one (8) and ferulic acid methyl ester (9) on the basis of spectral analysis...
November 2015: Zhong Yao Cai, Zhongyaocai, Journal of Chinese Medicinal Materials
Selcen Babaoğlu Aydaş, Seda Şirin, Belma Aslim
CONTEXT: Phenylketonuria (PKU) is the most common hereditary defect of phenylalanine hydroxylase (PAH) enzyme achieving the hydroxylation of phenylalanine (Phe). Phenylalanine ammonia lyase (PAL) converts Phe to a harmless metabolite, trans-cinnamic acid (TCA) in plants and PAL enzyme activity is fairly high in plants rich in flavonoids. OBJECTIVE: The study aimed the biochemical analysis of PAL form Centaurea depressa BIEB. (Asteraceae) a flavonoid rich plant. This study may form the main frame of future research efforts for the development of a plant preparation aimed for oral intake in PKU patients in an attempt to enrich their diet by allowing them to ingest some food stuff containing Phe without being exposed to complications...
June 1, 2016: Pharmaceutical Biology
Ritesh Kumar, Divya Vashisth, Amita Misra, Md Qussen Akhtar, Syed Uzma Jalil, Karuna Shanker, Madan Mohan Gupta, Prashant Kumar Rout, Anil Kumar Gupta, Ajit Kumar Shasany
Cinnamate-4-hydroxylase (C4H) converts trans-cinnamic acid (CA) to p-coumaric acid (COA) in the phenylpropanoid/lignin biosynthesis pathway. Earlier we reported increased expression of AaCYP71AV1 (an important gene of artemisinin biosynthesis pathway) caused by CA treatment in Artemisia annua. Hence, AaC4H gene was identified, cloned, characterized and silenced in A. annua with the assumption that the elevated internal CA due to knock down may increase the artemisinin yield. Accumulation of trans-cinnamic acid in the plant due to AaC4H knockdown was accompanied with the reduction of p-coumaric acid, total phenolics, anthocyanin, cinnamate-4-hydroxylase (C4H) and phenylalanine ammonia lyase (PAL) activities but increase in salicylic acid (SA) and artemisinin...
2016: Scientific Reports
Jing-Long Liang, Li-Qiong Guo, Jun-Fang Lin, Ze-Qi He, Fa-Ji Cai, Jun-Fei Chen
Pinosylvin as a bioactive stilbene is of great interest for food supplements and pharmaceuticals development. In comparison to conventional extraction of pinosylvin from plant sources, biosynthesis engineering of microbial cell factories is a sustainable and flexible alternative method. Current synthetic strategies often require expensive phenylpropanoic precursor and inducer, which are not available for large-scale fermentation process. In this study, three bioengineering strategies were described to the development of a simple and economical process for pinosylvin biosynthesis in Escherichia coli...
June 2016: World Journal of Microbiology & Biotechnology
Guang Wang, Liying Wu, Hong Zhang, Wenjia Wu, Mengmeng Zhang, Xiaofeng Li, Hui Wu
To clarify the mechanisms of selenium (Se) tolerance in peanut seedlings, we grew peanut seedlings with sodium selenite (0, 3, and 6 mg/L), and investigated the phenylpropanoids metabolism in seedling roots. The results showed that selenite up-regulated the expression of genes and related enzyme activities involving in the phenylpropanoids biosynthesis cascade, such as phenylalanine ammonia-lyase, trans-cinnamate-4-hydroxylase, chalcone synthase, chalcone isomerase, and cinnamyl-alcohol dehydrogenase. Selenite significantly increased phenolic acids and flavonoids, which contributed to the alleviation of selenite-induced stress...
May 11, 2016: Journal of Agricultural and Food Chemistry
Bingyan Zhu, Boyang Shang, Yi Li, Yongsu Zhen
Previous studies have shown that trans-cinnamic acid (tCA) has a broad spectrum of biological activities, and exhibits antioxidant, anti-inflammatory and anticancer properties. In addition, tCA and a variety of its analogs have been detected as gut microbe‑derived metabolites exerting various biological effects in the colon. The aim of this study was to assess the antitumor activity of tCA in vitro and in vivo, in particular its therapeutic efficacy against colon cancer xenografts in athymic mice. Furthermore, it aimed to examine the effects of tCA on histone deacetylases (HDACs) and to identify the underlying molecular mechanisms...
May 2016: Molecular Medicine Reports
Unwoo Kang, Jiyoung Park, Ah-Reum Han, Mi Hee Woo, Je-Hyun Lee, Sang Kook Lee, Tong-Shin Chang, Hyun Ae Woo, Eun Kyoung Seo
A new cytoprotective compound, 1-[(4S)-3,4-dihydro-4-hydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl]-ethanone (1) was isolated from the flower buds of Tussilago farfara L. (Compositae), together with eight known compounds, 3,4-dicaffeoyl isoquinic acid (2), trans-cinnamic acid (3), 4-hydroxyacetophenone (4), 4,5-dicaffeoylquinic acid methyl ester (5), 3,5-dicaffeoylquinic acid methyl ester (6), 4-hydroxybenzoic acid (7), isoquercetrin (8), and ligucyperonol (9). Compounds 2-4 were found in this plant for the first time...
April 2016: Archives of Pharmacal Research
Yun Jung Lee, So Min Lee, Xiang Cui, Jung Joo Yoon, Hyun Cheol Oh, Youn Chul Kim, Min Cheol Park, Dae Gill Kang, Ho Sub Lee
ETHNOPHARMACOLOGICAL RELEVANCE: Oryeongsan (ORS, Wulingsan) has been reported to possess renal protective effects from renal diseases such as diabetes-induced renal damage, and nephrocalcinosis. AIM OF THE STUDY: This study was conducted to evaluate the quantitative analysis and the inhibitory effect of ORS on hypertonic stress-induced water channel and apoptosis in murine inner medullary collecting duct cell line (mIMCD-3). MATERIALS AND METHODS: Chromatographic and NMR spectroscopic analysis were performed and water balance regulation was determined by Western blot, RT-PCR, and immunofluorescnece...
June 5, 2016: Journal of Ethnopharmacology
Yeong Hun Song, Dae Wook Kim, Marcus J Curtis-Long, Chanin Park, Minky Son, Jeong Yoon Kim, Heung Joo Yuk, Keun Woo Lee, Ki Hun Park
The α-glucosidase inhibitory potential of Tribulus terrestris extracts has been reported but as yet the active ingredients are unknown. This study attempted to isolate the responsible metabolites and elucidate their inhibition mechanism of α-glucosidase. By fractionating T. terristris extracts, three cinnamic acid amide derivatives (1-3) were ascertained to be active components against α-glucosidase. The lead structure, N-trans-coumaroyltyramine 1, showed significant inhibition of α-glucosidase (IC50 = 0...
May 23, 2016: European Journal of Medicinal Chemistry
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