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https://www.readbyqxmd.com/read/29454185/preterm-infants-undergoing-laparotomy-for-necrotizing-enterocolitis-or-spontaneous-intestinal-perforation-display-evidence-of-impaired-cerebrovascular-autoregulation
#1
Sara J Kuik, Michelle E van der Laan, Margot T Brouwer-Bergsma, Jan B F Hulscher, Anthony R Absalom, Arend F Bos, Elisabeth M W Kooi
BACKGROUND: Preterm infants requiring surgery are at risk of impaired neurocognitive development caused, possibly, by cerebral ischemia associated with impaired cerebrovascular autoregulation (CAR). We evaluated CAR before, during, and after laparotomy. STUDY DESIGN: This was a hypothesis generating prospective observational cohort study. SUBJECTS: We included preterm infants requiring surgery for necrotizing enterocolitis (NEC) or spontaneous intestinal perforation (SIP)...
February 14, 2018: Early Human Development
https://www.readbyqxmd.com/read/29454160/vascular-parameters-continue-to-decrease-post-exposure-with-simultaneous-but-not-individual-exposure-to-bpa-and-hypoxia-in-zebrafish-larvae
#2
Alysha D Cypher, Bryce Fetterman, Brian Bagatto
How fish respond to hypoxia, a common stressor, can be altered by simultaneous exposure to pollutants like bisphenol A (BPA), a plasticizer. BPA is cardiotoxic and interferes with the hypoxia inducible factor pathway (HIF-1α), therefore disrupting the hypoxic response. Co-exposure to hypoxia and BPA also causes severe bradycardia and reduced cardiac output in zebrafish larvae. The purpose of this work was to determine how the cardiovascular effects of co-exposure vary with BPA concentration and persist beyond exposure...
February 14, 2018: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/29454105/assessing-the-repeatability-of-absolute-cmro-2-oef-and-haemodynamic-measurements-from-calibrated-fmri
#3
Alberto Merola, Michael A Germuska, Kevin Murphy, Richard G Wise
As energy metabolism in the brain is largely oxidative, the measurement of cerebral metabolic rate of oxygen consumption (CMRO 2 ) is a desirable biomarker for quantifying brain activity and tissue viability. Currently, PET techniques based on oxygen isotopes are the gold standard for obtaining whole brain CMRO 2 maps. Among MRI techniques that have been developed as an alternative are dual calibrated fMRI (dcFMRI) methods, which exploit simultaneous measurements of BOLD and ASL signals during a hypercapnic-hyperoxic experiment to modulate brain blood flow and oxygenation...
February 14, 2018: NeuroImage
https://www.readbyqxmd.com/read/29453921/changes-in-erythrocyte-deformability-during-day-and-possible-role-of-melatonin
#4
Rastislav Vazan, Katarina Plauterova, Gabriela Porubska, Jana Radosinska
OBJECTIVES: The deformability of erythrocytes is their ability to change shape in order to pass through the capillaries. Th is is necessary for quality of microcirculation and sufficient delivery of oxygen to the tissues. Th e aim of our study was to investigate the possible spontaneous changes in the erythrocyte deformability during day and evaluation of the possible direct effects of melatonin (hormone involved in regulation of biorhythms) on the erythrocyte deformability. METHODS: Samples of capillary blood were taken from 12 healthy volunteers in the morning (8:00) and early in the evening (16:30)...
January 1, 2018: Endocrine Regulations
https://www.readbyqxmd.com/read/29453682/persistent-pulmonary-hypertension-and-histologic-chorioamnionitis-in-preterm-infants-controlled-study
#5
N Katz, Y Bar-Or, A Raucher-Sterrnfeld, A Tamir, D Kohelet
Persistent pulmonary hypertension (PPHN) of the newborn is one of the most challenging acute disorders of postnatal transition with substantial morbidity and mortality. The aim of the study was to find if there is an association between persistent pulmonary hypertension and histologic chorioamnionitis in preterm infants. 27 preterm infants with echocardiographic evidence of PPHN within the first 3 days of life were eligible for the study. A matched control group of 27 patients was chosen according to gestational age, date of birth, and gender...
February 16, 2018: Pediatric Cardiology
https://www.readbyqxmd.com/read/29453636/assessment-of-oximetry-based-statistical-classifiers-as-simplified-screening-tools-in-the-management-of-childhood-obstructive-sleep-apnea
#6
Andrea Crespo, Daniel Álvarez, Leila Kheirandish-Gozal, Gonzalo C Gutiérrez-Tobal, Ana Cerezo-Hernández, David Gozal, Roberto Hornero, Félix Del Campo
PURPOSE: A variety of statistical models based on overnight oximetry has been proposed to simplify the detection of children with suspected obstructive sleep apnea syndrome (OSAS). Despite the usefulness reported, additional thorough comparative analyses are required. This study was aimed at assessing common binary classification models from oximetry for the detection of childhood OSAS. METHODS: Overnight oximetry recordings from 176 children referred for clinical suspicion of OSAS were acquired during in-lab polysomnography...
February 16, 2018: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/29453603/repeatable-and-reproducible-measurements-of-myocardial-oxidative-metabolism-blood-flow-and-external-efficiency-using-11-c-acetate-pet
#7
Kai Yi Wu, Vincent Dinculescu, Jennifer M Renaud, Shin-Yee Chen, Ian G Burwash, Lisa M Mielniczuk, Rob S B Beanlands, Robert A deKemp
BACKGROUND: Non-invasive approaches to investigate myocardial efficiency can help track the progression of heart failure (HF). This study evaluates the repeatability and reproducibility of 11 C-acetate positron emission tomography (PET) imaging of oxidative metabolism. METHODS AND RESULTS: Dynamic 11 C-acetate PET scans were performed at baseline and followup (47 ± 22 days apart) in 20 patients with stable HF with reduced ejection fraction. Two observers blinded to patients' clinical data used FlowQuant ® to evaluate test-retest repeatability, as well as intra- and inter-observer reproducibility of 11 C-acetate tracer uptake and clearance rates, for the measurement of myocardial oxygen consumption (MVO 2 ), myocardial external efficiency (MEE), work metabolic index (WMI), and myocardial blood flow...
February 16, 2018: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/29453570/molecular-mechanisms-and-signaling-pathways-involved-in-the-nutritional-support-of-spermatogenesis-by-sertoli-cells
#8
Luís Crisóstomo, Marco G Alves, Agostina Gorga, Mário Sousa, María F Riera, María N Galardo, Silvina B Meroni, Pedro F Oliveira
Sertoli cells play a central role in spermatogenesis. They maintain the blood-testis barrier, an essential feature of seminiferous tubules which creates the proper environment for the occurrence of the spermatogenesis. However, this confinement renders germ cells almost exclusively dependent on Sertoli cells' nursing function and support. Throughout spermatogenesis, differentiating sperm cells become more specialized, and their biochemical machinery is insufficient to meet their metabolic demands. Although the needs are not the same at all differentiation stages, Sertoli cells are able to satisfy their needs...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29453477/effects-of-bilateral-nasal-packing-on-oxygen-saturation-and-blood-pressure
#9
Meera Bista
INTRODUCTION: Nasal packing is one of the most common rhinological procedures in ENT practice exerting local in nose and systemic effects. Systemic effects may be due to poor sleep quality, respiratory difficulty, decreased oxygen saturation, circulatory problems and toxic shock syndrome which can threaten the life of a person.The study was done to investigate the effect on bilateral nasal packing on blood oxygen saturation and blood pressure changes. METHODS: A cross-sectional prospective study was undertaken in Kathmandu Medical College from January 2017 to June 2017...
October 2017: JNMA; Journal of the Nepal Medical Association
https://www.readbyqxmd.com/read/29453330/interphysician-agreement-on-subclassification-of-myocardial-infarction
#10
Anton Gard, Bertil Lindahl, Gorav Batra, Nermin Hadziosmanovic, Marcus Hjort, Karolina Elisabeth Szummer, Tomasz Baron
OBJECTIVE: The universal definition of myocardial infarction (MI) differentiates MI due to oxygen supply/demand mismatch (type 2) from MI due to plaque rupture (type 1) as well as from myocardial injuries of non-ischaemic or multifactorial nature. The purpose of this study was to investigate how often physicians agree in this classification and what factors lead to agreement or disagreement. METHODS: A total of 1328 patients diagnosed with MI at eight different Swedish hospitals 2011 were included...
February 16, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29452984/quantitative-cerebrovascular-pathology-in-a-community-based-cohort-of-older-adults
#11
Swati Rane, Natalie Koh, Peter Boord, Tara Madhyastha, Mary K Askren, Suman Jayadev, Brenna Cholerton, Eric Larson, Thomas J Grabowski
Cerebrovascular disease, especially small vessel pathology, is the leading comorbidity in degenerative disorders. We applied arterial spin labeling and cerebrovascular reserve (CVR) imaging to quantify small vessel disease and study its effect on cognitive symptoms in nondemented older adults from a community-based cohort. We evaluated baseline cerebral blood flow (CBF) using arterial spin labeling and percent signal change as a marker of CVR using blood-oxygen level-dependent imaging following a breath-hold stimulus...
January 31, 2018: Neurobiology of Aging
https://www.readbyqxmd.com/read/29452581/prospective-observational-study-on-assessing-the-hemodynamic-relevance-of-patent-ductus-arteriosus-with-frequency-domain-near-infrared-spectroscopy
#12
Christoph E Schwarz, Antonio Preusche, Martin Wolf, Christian F Poets, Axel R Franz
BACKGROUND: What constitutes a hemodynamically relevant patent ductus arteriosus (hrPDA) in preterm infants is unclear. Different clinical and echocardiographic parameters are used, but a gold standard definition is lacking. Our objective was to evaluate associations between regional cerebral tissue oxygen saturation (rcStO 2 ), fraction of tissue oxygen extraction (rcFtO 2 E) measured by frequency domain near-infrared spectroscopy (fd-NIRS) and their correlation to echocardiographic, Doppler-ultrasound, and clinical parameters in preterm infants with and without a hrPDA...
February 16, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29452577/polymerase-delta-interacting-protein-2-deficiency-protects-against-blood-brain-barrier-permeability-in-the-ischemic-brain
#13
Marina S Hernandes, Bernard Lassègue, Lula L Hilenski, Jonathan Adams, Ning Gao, Chia-Yi Kuan, Yu-Yo Sun, Lihong Cheng, Daniel S Kikuchi, Manuel Yepes, Kathy K Griendling
BACKGROUND: Polymerase δ-interacting protein 2 (Poldip2) is a multifunctional protein that regulates vascular extracellular matrix composition and matrix metalloproteinase (MMP) activity. The blood-brain barrier (BBB) is a dynamic system assembled by endothelial cells, basal lamina, and perivascular astrocytes, raising the possibility that Poldip2 may be involved in maintaining its structure. We investigated the role of Poldip2 in the late BBB permeability induced by cerebral ischemia...
February 17, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29452370/blood-cardioplegia-for-cardiac-surgery-in-acute-myocardial-infarction-rat-experiments-with-two-widely-used-solutions
#14
Andreas Boening, Lena Assling-Simon, Martina Heep, Kerstin Boengler, Bernd Niemann, Julia Schipke, Christian Mühlfeld, Philippe Grieshaber
OBJECTIVES: Blood cardioplegia (BCP) can be used in different ways to protect the heart from ischaemia-reperfusion injury during cardiac surgery. Because there could be differences between warm and cold intermittent cardioplegia with or without warm reperfusion, we investigated the influence of 2 blood cardioplegia solutions on cardiac function, metabolism and infarct size in stable and infarcted rat hearts. METHODS: The hearts of 32 male Wistar rats were excised and inserted into a blood-perfused isolated heart apparatus...
February 14, 2018: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29452273/3d-bioprinted-functional-and-contractile-cardiac-tissue-constructs
#15
Zhan Wang, Sang Jin Lee, Heng-Jie Cheng, James J Yoo, Anthony Atala
Bioengineering of a functional cardiac tissue composed of primary cardiomyocytes has great potential for myocardial regeneration and in vitro tissue modeling. However, its applications remain limited because the cardiac tissue is a highly organized structure with unique physiologic, biomechanical, and electrical properties. In this study, we undertook a proof-of-concept study to develop a contractile cardiac tissue with cellular organization, uniformity, and scalability by using three-dimensional (3D) bioprinting strategy...
February 13, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29452265/characterizing-the-modulation-of-resting-state-fmri-metrics-by-baseline-physiology
#16
Powell P W Chu, Ali M Golestani, Jonathan B Kwinta, Yasha B Khatamian, J Jean Chen
The blood-oxygenation level dependent (BOLD) functional magnetic resonance imaging (fMRI) signal is commonly used to assess functional connectivity across brain regions, particularly in the resting state (rs-fMRI). However, the BOLD fMRI signal is not merely a representation of neural activity, but a combination of neural activity and vascular response. These aspects of the BOLD signal are easily influenced by systemic physiology, potentially biasing BOLD-based functional connectivity measurements. In this work, we focus on the following physiological modulators of the BOLD signal: cerebral blood flow (CBF), venous blood oxygenation, and cerebrovascular reactivity (CVR)...
February 13, 2018: NeuroImage
https://www.readbyqxmd.com/read/29452155/comparative-developmental-biology-of-the-cardiac-inflow-tract
#17
REVIEW
Rita Carmona, Laura Ariza, Ana Cañete, Ramón Muñoz-Chápuli
The vertebrate heart receives the blood through the cardiac inflow tract. This area has experienced profound changes along the evolution of vertebrates; changes that have a reflection in the cardiac ontogeny. The development of the inflow tract involves dynamic changes due to the progressive addition of tissue derived from the secondary heart field. The inflow tract is the site where oxygenated blood coming from lungs is received separately from the systemic return, where the cardiac pacemaker is established and where the proepicardium develops...
February 13, 2018: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29452031/prehospital-cervical-spine-motion-immobilization-versus-spine-motion-restriction
#18
Erik E Swartz, W Steven Tucker, Matthew Nowak, Jason Roberto, Amy Hollingworth, Laura C Decoster, Thomas W Trimarco, Jason P Mihalik
OBJECTIVE: This study aims to evaluate the efficacy of two different spinal immobilization techniques on cervical spine movement in a simulated prehospital ground transport setting. METHODS: A counterbalanced crossover design was used to evaluate two different spinal immobilization techniques in a standardized environment. Twenty healthy male volunteers (age = 20.9 ± 2.2 yr) underwent ambulance transport from a simulated scene to a simulated emergency department setting in two separate conditions: utilizing traditional spinal immobilization (TSI) and spinal motion restriction (SMR)...
February 16, 2018: Prehospital Emergency Care
https://www.readbyqxmd.com/read/29451994/stroop-task-related-brain-activity-in-patients-with-insomnia-changes-after-cognitive-behavioral-therapy-for-insomnia
#19
Jeong Yeon Hwang, Nambeom Kim, Soohyun Kim, Juhyun Park, Jae-Won Choi, Seog Ju Kim, Chang-Ki Kang, Yu Jin Lee
OBJECTIVE/BACKGROUND: In the present study, we compared differences in brain activity during the Stroop task between patients with chronic insomnia disorder (CID) and good sleepers (GS). Furthermore, we evaluated changes in Stroop task-related brain activity after cognitive-behavioral therapy for insomnia (CBT-I). PARTICIPANTS/METHODS: The final analysis included 21 patients with CID and 25 GS. All participants underwent functional magnetic resonance imaging (fMRI) while performing the color-word Stroop task...
February 16, 2018: Behavioral Sleep Medicine
https://www.readbyqxmd.com/read/29450720/diabetic-kidney-disease-is-there-a-role-for-glycemic-variability
#20
REVIEW
Savitha Subramanian, Irl B Hirsch
PURPOSE OF REVIEW: Diabetes is the leading cause of kidney disease globally. Diabetic kidney disease (DKD) is a heterogeneous disorder manifested as albuminuria and/or decreasing GFR. Hyperglycemic burden is the major contributor to the development of DKD. In this article, we review the evidence for the contribution of glycemic variability and the pitfalls associated with use of hemoglobin A1c (A1C), the gold standard for assessment of glucose control, in the setting of DKD. RECENT FINDINGS: Glycemic variability, characterized by swings in blood glucose levels, can result in generation of mitochondrial reactive oxygen species, a putative inciting factor for hyperglycemia-induced alterations in intracellular metabolic pathways...
February 15, 2018: Current Diabetes Reports
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