keyword
MENU ▼
Read by QxMD icon Read
search

Blood oxygenator

keyword
https://www.readbyqxmd.com/read/29906796/regional-tissue-oxygen-extraction-and-severity-of-anemia-in-very-low-birth-weight-neonates-a-pilot-nirs-analysis
#1
Jonathan P Mintzer, Boriana Parvez, Edmund F La Gamma
OBJECTIVE:  Anemia causes blood flow redistribution and altered tissue metabolic behavior to sustain homeostatic oxygen consumption. We hypothesized that anemia severity would correlate with increased regional fractional tissue oxygen extraction among premature neonates. STUDY DESIGN:  Regional oxygen extraction was calculated using pulse oximetry and near-infrared spectroscopy data among neonates <1,250 g during their first 10 postnatal days. Oxygen extraction was assessed for correlations with raw hematocrit levels and following grouping into hematocrit quartiles...
June 15, 2018: American Journal of Perinatology
https://www.readbyqxmd.com/read/29906492/the-influence-of-ageing-on-the-extrapineal-melatonin-synthetic-pathway
#2
Branka Popović, Milica Velimirović, Tihomir Stojković, Gavrilo Brajović, Silvio R De Luka, Ivan Milovanović, Srdjan Stefanović, Dragica Nikolić, Jasna L Ristić-Djurović, Nataša D Petronijević, Alexander M Trbovich
Ageing affects various physiological and metabolic processes in a body and a progressive accumulation of oxidative damage stands out as often used explanation. One of the most powerful scavenger of reactive oxygen species (ROS) in all organs is melatonin. A majority of melatonin supplied to the body via blood originates from the pineal gland. However, we have been interested in a locally produced melatonin. We have used 2.5- and 36-months-old Wistar rats. Tissues were collected and gene expression of AA-NAT and ASMT, the two key enzymes in a synthesis of melatonin, was determined in brain, liver, kidney, heart, skin, and intestine...
June 12, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29906223/new-mouse-model-of-pulmonary-hypertension-induced-by-respiratory-syncytial-virus-bronchiolitis
#3
Dai Kimura, Jordy Saravia, Sridhar Jaligama, Isabella McNamara, Luan D Vu, Ryan D Sullivan, Salvatore Mancarella, Dahui You, Stephania A Cormier
Pulmonary hypertension (PH) has been observed in up to 75% of infants with moderate to severe respiratory syncytial virus (RSV) bronchiolitis and is associated with significant morbidity and mortality in infants with congenital heart disease. The purpose of this study was to establish a mouse model of PH secondary to RSV bronchiolitis that mimics the disease etiology as it occurs in infants. Neonatal mice were infected with RSV at 5 days of age, and then re-infected 4 weeks later. Serum free medium was administered to age-matched mice as control...
June 15, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29905672/alterations-in-mitochondrial-function-in-blood-cells-obtained-from-patients-with-sepsis-presenting-to-an-emergency-department
#4
David H Jang, Clinton J Orloski, Shawn Owiredu, Frances S Shofer, John C Greenwood, David M Eckmann
OBJECTIVE: Mitochondrial dysfunction has been implicated as a key cellular event leading to organ dysfunction in sepsis. Our objective is to measure changes in mitochondrial bioenergetics in subjects with early presentation of sepsis to provide insight into the incompletely understood pathophysiology of the dysregulated host response in sepsis. DESIGN: Prospective observational study SETTING:: Single site tertiary academic emergency department SUBJECTS:: We enrolled a total of 48 subjects were enrolled in the study, 10 with sepsis or septic shock, 10 with infection without sepsis, 14 older and 14 younger healthy controls...
June 13, 2018: Shock
https://www.readbyqxmd.com/read/29905656/pain-processing-in-the-human-brainstem-and-spinal-cord-before-during-and-after-the-application-of-noxious-heat-stimuli
#5
P W Stroman, G Ioachim, J M Powers, R Staud, C Pukall
Descending regulation of spinal cord responses to nociceptive signaling has a strong influence on pain perception. Prior studies using functional magnetic resonance imaging (fMRI) have indicated that in addition to reactive responses to nociceptive signals there is a continuous component to regulation, and that it may vary with differences in pain sensitivity. We hypothesize that this continuous regulation component occurs routinely in fMRI studies prior to noxious stimulation, as well as during, and following stimulation...
June 12, 2018: Pain
https://www.readbyqxmd.com/read/29905377/red-blood-cell-adhesion-to-heme-activated-endothelial-cells-reflects-clinical-phenotype-in-sickle-cell-disease
#6
Erdem Kucukal, Anton Ilich, Nigel S Key, Jane A Little, Umut A Gurkan
In sickle cell disease (SCD), 'disease severity' associates with increased RBC adhesion to quiescent endothelium, but the impact on activated endothelium is not known. Increased concentrations of free heme result from intravascular hemolysis in SCD. Heme is essential for aerobic metabolism, and plays an important role in numerous biological processes. Excess free heme induces reactive oxygen species generation and endothelial activation, which are associated with cardiovascular disorders including atherosclerosis, hypertension, and thrombosis...
June 15, 2018: American Journal of Hematology
https://www.readbyqxmd.com/read/29905107/the-effects-of-capture-restraint-and-transport-on-hematologic-plasma-biochemical-and-blood-gas-values-in-dalmatian-pelicans-pelecanus-crispus
#7
Matthew E Kinney
To determine the effect of capture and restraint on hematologic, plasma biochemical, and venous blood gas values in Dalmatian pelicans ( Pelecanus crispus), blood samples were collected and temperature and heart rate were recorded in 13 pelicans (5 males and 8 females) immediately after capture from a large field exhibit. Repeat sampling was performed after transport, a mean of 74 minutes after initial evaluation. When compared with values at initial sampling to the time of capture, significant increases were documented in the heterophil : lymphocyte ratio (H : L), carbon dioxide (CO2 ), bicarbonate (HCO3 ), total carbon dioxide (Tco2 ), base excess (BE), and partial pressure of carbon dioxide (Pco2 ) values after 74 minutes...
June 2018: Journal of Avian Medicine and Surgery
https://www.readbyqxmd.com/read/29904401/analysis-on-the-association-between-sperm-dna-fragmentation-index-and-conventional-semen-parameters-blood-microelements-and-seminal-plasma-ros-in-male-patients-with-infertility
#8
Deng'e Xie, Chen Lu, Ying Zhu, Sulan Zhu, Er-Jiang Yang, Xin Jin
We conducted this study to analyze the sperm DNA fragmentation index, conventional semen parameters, blood microelements and seminal plasma reactive oxygen species (ROS) in patients with male infertility to determine the association between each of the above male physiological parameters and DNA fragmentation index and infertility. Eighty cases of infertile males and 20 cases of normal males with children were divided into the infertility and control groups, respectively. Sperm DNA fragmentation index, conventional semen parameters, serum microelement content and seminal plasma ROS levels were detected, and the existing correlation between sperm DNA fragmentation index and the various physiological parameters were studied...
June 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29904335/neuroprotection-targeting-protein-misfolding-on-chronic-cerebral-hypoperfusion-in-the-context-of-metabolic-syndrome
#9
REVIEW
María I Herrera, Lucas D Udovin, Nicolás Toro-Urrego, Carlos F Kusnier, Juan P Luaces, Matilde Otero-Losada, Francisco Capani
Metabolic syndrome (MetS) is a cluster of risk factors that lead to microvascular dysfunction and chronic cerebral hypoperfusion (CCH). Long-standing reduction in oxygen and energy supply leads to brain hypoxia and protein misfolding, thereby linking CCH to Alzheimer's disease. Protein misfolding results in neurodegeneration as revealed by studying different experimental models of CCH. Regulating proteostasis network through pathways like the unfolded protein response (UPR), the ubiquitin-proteasome system (UPS), chaperone-mediated autophagy (CMA), and macroautophagy emerges as a novel target for neuroprotection...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29904286/utility-of-venous-blood-gases-in-severe-sepsis-and-septic-shock
#10
Heath D White, Alfredo Vazquez-Sandoval, Pedro F Quiroga, Juhee Song, Shirley F Jones, Alejandro C Arroliga
Acid-base status is frequently assessed in severe sepsis and septic shock. Venous blood gas sampling is proposed as a less-invasive modality but lacks evidence within this population. The objective of this study was to evaluate the correlation and agreement between arterial blood gas (ABG), peripheral venous blood gas (pVBG), and central venous blood gas (cVBG) in severe sepsis and septic shock. We conducted a prospective, observational cohort study in subjects admitted to the medical intensive care unit. Simultaneous blood gas samples, including ABG, pVBG, and cVBG, were analyzed for correlation and agreement...
July 2018: Proceedings of the Baylor University Medical Center
https://www.readbyqxmd.com/read/29903693/mechanical-circulatory-support-in-patients-with-cardiogenic-shock-in-intensive-care-units-a-position-paper-of-the-unit%C3%A3-de-soins-intensifs-de-cardiologie-group-of-the-french-society-of-cardiology-endorsed-by-the-groupe-ath%C3%A3-rome-et-cardiologie-interventionnelle
#11
REVIEW
Laurent Bonello, Clement Delmas, Guillaume Schurtz, Guillaume Leurent, Eric Bonnefoy, Nadia Aissaoui, Patrick Henry
Cardiogenic shock (CS) is a major challenge in contemporary cardiology. Despite a better understanding of the pathophysiology of CS, its management has only improved slightly. The prevalence of CS has remained stable over the past decade, but its outcome has seen few improvements, with the 1-month mortality rate still in the range of 40-60%. Inotropes and vasopressors are the first-line therapies for CS, but they are associated with significant hazards, and have well-known deleterious effects. Furthermore, a significant number of patients develop refractory CS with haemodynamic instability, causing critical organ hypoperfusion and/or pulmonary congestion, despite increasing doses of catecholamines...
June 11, 2018: Archives of Cardiovascular Diseases
https://www.readbyqxmd.com/read/29903683/correlating-oxygen-delivery-during-cardiopulmonary-bypass-with-the-neurologic-injury-biomarker-ubiquitin-c-terminal-hydrolase-l1-uch-l1
#12
J Trent Magruder, Charles D Fraser, Joshua C Grimm, Todd C Crawford, Claude A Beaty, Alejandro Suarez-Pierre, Ronald L Hayes, Michael V Johnston, William A Baumgartner
OBJECTIVE: The authors sought to assess the relationship between low oxygen delivery (DO2 ) during cardiopulmonary bypass (CPB) and a neuron-specific biomarker of neurologic injury, ubiquitin C-terminal hydrolase L1 (UCH-L1). DESIGN: Retrospective analysis of patient charts and prospectively collected blood samples. SETTING: University-affiliated tertiary care hospital. PARTICIPANTS: Adult patients undergoing cardiac surgery on CPB...
June 11, 2018: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29903197/-effect-and-mechanism-of-three-kinds-of-drinking-water-on-blood-pressure-of-hypertensive-mice
#13
Qian Sun, Ronghe Chen, Fan Xin, Guohong Ruan
OBJECTIVE: To explore the effect of three kinds of drinking water and its possible mechanism on blood pressure of hypertensive mice. METHODS: The water quality parameters were measured for three kinds of drinking water, and the parameters includedtotal dissolved solids( TDS), oxygen consumed( OC), p H, oxidation reduction potential( ORP), electric conductivity( EC), dissolved hydrogen, calcium and magnesium. Establishment of mouse model of high blood pressure by using N'-nitro-L-arginine methyl ester hydrochloride( L-NAME) for 30 days...
November 2017: Wei Sheng Yan Jiu, Journal of Hygiene Research
https://www.readbyqxmd.com/read/29902244/upregulation-of-krebs-cycle-and-anaerobic-glycolysis-activity-early-after-onset-of-liver-ischemia
#14
Tom S Chan, Shamir Cassim, Valérie-Ann Raymond, Sven Gottschalk, Grégory Merlen, Claudia Zwingmann, Pascal Lapierre, Peter Darby, Cyril David Mazer, Marc Bilodeau
The liver is a highly vascularized organ receiving a dual input of oxygenated blood from the hepatic artery and portal vein. The impact of decreased blood flow on glucose metabolism and how hepatocytes could adapt to this restrictive environment are still unclear. Using the left portal vein ligation (LPVL) rat model, we found that cellular injury was delayed after the onset of liver ischemia. We hypothesized that a metabolic adaptation by hepatocytes to maintain energy homeostasis could account for this lag phase...
2018: PloS One
https://www.readbyqxmd.com/read/29902061/validity-of-the-modified-shuttle-walk-test-to-assess-cardiorespiratory-fitness-after-exercise-intervention-in-overweight-obese-adults-with-primary-hypertension
#15
Borja Jurio-Iriarte, Peter H Brubaker, Ilargi Gorostegi-Anduaga, Pablo Corres, Aitor Martinez Aguirre-Betolaza, Sara Maldonado-Martin
The study aimed to assess whether the Modified Shuttle Walk Test (MSWT) can detect changes in cardiorespiratory fitness (CRF) in overweight/obese people with hypertension (HTN) after an exercise intervention evaluating the equation presented in the previous research by Jurio-Iriarte et al. Participants (N= 248) performed a peak cardiorespiratory exercise test (CPET) and MSWT before and after 16-weeks of different types of aerobic exercise intervention. The formula of Jurio-Iriarte et al. was used to predict peak oxygen uptake (V̇O2peak )...
June 14, 2018: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/29901433/impaired-cortical-autonomic-responses-during-sympathetic-activation-in-neurogenic-orthostatic-hypotension-characterized-by-post-ganglionic-autonomic-dysfunction
#16
Jacquie R Baker, Justin R Paturel, Kurt Kimpinski
PURPOSE: Neurogenic orthostatic hypotension (NOH), is a cardinal feature of autonomic dysfunction. The cortical autonomic network (CAN) is a network of brain regions associated with autonomic function. Therefore, our objective was to investigate whether impairment of CAN structures is involved in the pathophysiology of NOH. METHODS: Fifteen controls (63{plus minus}13 years) and fifteen NOH patients (67{plus minus}6 years; p=0.2) with peripheral autonomic dysfunction completed standard tests of parasympathetic [Deep Breathing (DB)] and sympathetic [Valsalva maneuver (VM)] activation during a functional MRI...
June 14, 2018: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29900230/spleen-data-cerium-oxide-nanoparticles-attenuate-polymicrobial-sepsis-induced-spenic-damage-in-male-sprague-dawley-rats
#17
Kevin M Rice, Venkata Vinay Kumar Bandarupalli, Nandini D P K Manne, Eric R Blough
Sepsis is a serious life threatening medical emergency which, if not treated properly, oftentimes results in organ failure and death. Current sepsis treatment protocols are largely centered on the use of antibiotics and supportive care. Recent studies have suggested that antibiotics fail to be effective for sepsis treatment when administered during hypo-dynamic phase of sepsis that is usually characterized by the presence of a cytokine storm. As such, there is an urgent need to develop novel therapeutic drugs that target the inflammatory cytokines that are secreted as a result of increased reactive oxygen species...
June 2018: Data in Brief
https://www.readbyqxmd.com/read/29898113/mineral-supplementation-stimulates-the-immune-system-and-antioxidant-responses-of-dairy-cows-and-reduces-somatic-cell-counts-in-milk
#18
Amanda C Warken, Leandro S Lopes, Nathieli B Bottari, Patrícia Glombowsky, Gabriela M Galli, Vera M Morsch, Maria Rosa C Schetinger, Aleksandro S DA Silva
The aim of this study was to evaluate whether the use of subcutaneous mineral supplementation would affect metabolic parameters, immunological response, milk quality and composition of dairy cows in the postpartum period. Twelve pregnant primiparous Holstein cows, were divided into two groups: six animals supplemented with the mineral complex (magnesium, phosphorus, potassium, selenium and copper), and six animals used as controls. Milk samples were collected every two other weeks postpartum up to sixty days of lactation to analyze composition and quality...
April 2018: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/29898056/in-vitro-and-in-vivo-biocompatibility-of-reoss%C3%A2-in-powder-and-putty-configurations
#19
Andréa Vaz Braga Pintor, Rodrigo Figueiredo de Brito Resende, Adriana Terezinha Novelino Neves, Gutemberg Gomes Alves, Paulo G Coelho, José Mauro Granjeiro, Monica Diuana Calasans-Maia
This study evaluated comparatively two configurations (powder and putty) of a composite biomaterial based on PLGA (Poly(lactide-co-glycolide)/nanoescale hydroxyapatite (ReOss®, Intra-Lock International) through microscopic morphology, in vitro cytotoxicity, biocompatibility and in vivo response as a bone substitute. SEM and EDS characterized the biomaterials before/after grafting. Cytocompatibility was assessed with murine pre-osteoblasts. Osteoconductivity and biocompatibility were evaluated in White New Zealand rabbits...
March 2018: Brazilian Dental Journal
https://www.readbyqxmd.com/read/29897049/changes-in-gray-matter-density-regional-homogeneity-and-functional-connectivity-in-methamphetamine-associated-psychosis-a-resting-state-functional-magnetic-resonance-imaging-fmri-study
#20
Shengyu Zhang, Qiang Hu, Tao Tang, Chao Liu, Chengchong Li, Yin-Yin Zang, Wei-Xiong Cai
BACKGROUND Using regional homogeneity (ReHo) blood oxygen level-dependent functional MR (BOLD-fMRI), we investigated the structural and functional alterations of brain regions among patients with methamphetamine-associated psychosis (MAP). MATERIAL AND METHODS This retrospective study included 17 MAP patients, 16 schizophrenia (SCZ) patients, and 18 healthy controls. Informed consent was obtained from all patients before the clinical assessment, the severity of clinical symptoms was evaluated prior to the fMRI scanning, and then images were acquired and preprocessed after each participant received 6-min fRMI scanning...
June 13, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
keyword
keyword
48592
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"