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https://www.readbyqxmd.com/read/27898982/evaluation-of-corneal-cross-linking-for-treatment-of-fungal-keratitis-using-confocal-laser-scanning-microscopy-on-an-ex-vivo-human-corneal-model
#1
Jawaher M Alshehri, David Caballero-Lima, M Chantal Hillarby, Susan G Shawcross, Arun Brahma, Fiona Carley, Nick D Read, Hema Radhakrishnan
Purpose: Some previous reports have established the use of photoactivated chromophore-induced corneal cross-linking (PACK-CXL) in treating fungal keratitis. The results of these case reports have often been conflicting. To systematically study the effect of PACK-CXL in the management of Fusarium keratitis, we have developed an ex vivo model of human corneal infection using eye-banked human corneas. Methods: Sixteen healthy ex vivo human corneas were divided into four study groups: (1) untreated control, (2) cross-linked, (3) infected with fungal spores, and (4) infected with fungal spores and then cross-linked...
November 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27096139/pack-cxl-corneal-cross-linking-in-infectious-keratitis
#2
REVIEW
David Tabibian, Cosimo Mazzotta, Farhad Hafezi
BACKGROUND: Corneal cross-linking (CXL) using ultraviolet light-A (UV-A) and riboflavin is a technique developed in the 1990's to treat corneal ectatic disorders such as keratoconus. It soon became the new gold standard in multiple countries around the world to halt the progression of this disorder, with good long-term outcomes in keratometry reading and visual acuity. The original Dresden treatment protocol was also later on used to stabilize iatrogenic corneal ectasia appearing after laser-assisted in situ keratomileusis (LASIK) and photorefractive keratectomy (PRK)...
2016: Eye and Vision (London, England)
https://www.readbyqxmd.com/read/27093581/current-and-future-applications-of-photoactivated-chromophore-for-keratitis-corneal-collagen-cross-linking-pack-cxl-an-overview-of-the-different-treatments-proposed
#3
A Abbouda, I Abicca, J L Alió
PURPOSE: To review the application of the PACK-CXL and to identify different treatment protocols according to the pathogens associated with keratitis. METHODS: A systematic review of 21 articles. The primary outcome was the healing of a corneal ulcer, defined as epithelization, blocking corneal melting. The secondary end-point was the recovery of visual acuity. RESULTS: We studied a total of 145 eyes. Infectious keratitis was associated with bacteria in 80 eyes (55...
April 19, 2016: Seminars in Ophthalmology
https://www.readbyqxmd.com/read/26949133/photoactivated-chromophore-for-moderate-to-severe-infectious-keratitis-as-an-adjunct-therapy-a-randomized-controlled-trial
#4
Ngamjit Kasetsuwan, Usanee Reinprayoon, Vannarut Satitpitakul
PURPOSE: To evaluate the efficacy of photoactivated chromophore for infectious keratitis (PACK-CXL) in the treatment of patients with moderate to severe infectious keratitis as adjunct therapy to the topical medication treatment. DESIGN: Randomized clinical trial. METHODS: Thirty eyes from 30 patients with moderate to severe infectious keratitis were randomized to receive either standard treatment plus PACK-CXL (n = 15) or standard treatment alone (control group, n = 15)...
May 2016: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/26867998/photodynamic-uva-riboflavin-bacterial-elimination-in-antibiotic-resistant-bacteria
#5
Karim Makdoumi, Anders Bäckman
BACKGROUND: To evaluate the bactericidal effect of clinical ultraviolet A (UVA)-settings used in PACK -CXL in antibiotic-resistant and non-resistant bacterial strains. METHODS: Well-characterized bacterial strains from clinical isolates, without and with antibiotic resistance were studied in a pairwise comparison. The evaluated pathogens were Staphylococcus epidermidis, Staphylococcus aureus, Pseudomonas aeruginosa, and Enterococcus faecalis. Bacteria were dispersed in PBS and diluted to a concentration of approximately 4 x 10(5) /mL...
February 11, 2016: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/26644282/evaluation-of-antifungal-efficacy-of-0-1-and-0-25-riboflavin-with-uva-a-comparative-in-vitro-study
#6
Kamil Bilgihan, Ayse Kalkanci, Huseyin Baran Ozdemir, Reyhan Yazar, Funda Karakurt, Erdem Yuksel, Feza Otag, Nilgun Karabicak, Sevtap Arikan-Akdagli
PURPOSE: Antifungal efficacy of photochemical cross-linking (PACK-CXL) with 0.1% and 0.25% riboflavin was evaluated with a comparative in vitro study. METHODS: Candida albicans and Aspergillus fumigatus ATCC reference strains, Candida parapsilosis, Aspergillus fumigatus, Fusarium solani, Scedosporium apiospermum, and Alternaria alternata strains isolated from keratitis cases were chosen as targeted microorganisms. Unique "black plate method" was developed in polystyrene microplates...
December 7, 2015: Current Eye Research
https://www.readbyqxmd.com/read/26469079/richoz-wins-troutman-prize-for-study-on-accelerated-photoactivated-chromophore-for-pack-cxl
#7
(no author information available yet)
No abstract text is available yet for this article.
October 2015: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/26252742/efficacy-of-primary-collagen-cross-linking-with-photoactivated-chromophore-pack-cxl-for-the-treatment-of-staphylococcus-aureus-induced-corneal-ulcers
#8
Kfir Tal, Orly Gal-Or, Shani Pillar, Alon Zahavi, Oded Rock, Irit Bahar
PURPOSE: To evaluate the efficacy of corneal collagen cross-linking (CXL) with photoactivated riboflavin (PACK-CXL) as primary therapy for Staphylococcus aureus-induced corneal ulcers in a rabbit model. METHODS: The right eye of 40 rabbits was inoculated with S. aureus to induce formation of central corneal ulcers (day 1). The ulcer was examined on day 5, and rabbits were randomly assigned to 4 groups-group A: no treatment (control); group B: topical antibiotic treatment (cefazolin 50 mg/mL, garamycin 14 mg/mL drops, chloramphenicol 5% ointment every 2 hours); group C: PACK-CXL; group D: PACK-CXL + topical antibiotics...
October 2015: Cornea
https://www.readbyqxmd.com/read/26005557/pack-cxl-corneal-cross-linking-for-treatment-of-infectious-keratitis
#9
David Tabibian, Olivier Richoz, Farhad Hafezi
This article discusses corneal cross-linking (CXL) and how it transitioned from a modality for treating corneal ectatic disorders to an inventive means of treating infectious keratitis. Initially, CXL was successfully developed to halt the progression of ectatic diseases such as keratoconus, using the standard Dresden protocol. Later, indications were extended to treat iatrogenic ectasia developing after laser-assisted in situ keratomileusis (LASIK) and photo-refractive keratectomy (PRK). At the time, it had been postulated that the combination of ultraviolet light with riboflavin could not only biomechanically strengthen the cornea but also was capable of destroying living cells and organisms including keratocytes and pathogens...
January 2015: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/25437486/accelerated-photoactivated-chromophore-for-keratitis-corneal-collagen-cross-linking-as-a-first-line-and-sole-treatment-in-early-fungal-keratitis
#10
David Tabibian, Olivier Richoz, Arnaud Riat, Jacques Schrenzel, Farhad Hafezi
PURPOSE: To report the use of accelerated photoactivated chromophore for keratitis-corneal collagen cross-linking (PACK-CXL) as a first-line treatment in a patient with an atypical fungal keratitis. METHODS: Case report and literature review. RESULTS: A patient who presented with a painful peripheral corneal infiltrate underwent PACK-CXL with a local limited abrasion and accelerated ultraviolet-A irradiation at 365 μm and 9 mW/cm² for 10 minutes...
December 2014: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/25437485/antibacterial-efficacy-of-accelerated-photoactivated-chromophore-for-keratitis-corneal-collagen-cross-linking-pack-cxl
#11
Olivier Richoz, Sabine Kling, Florence Hoogewoud, Arthur Hammer, David Tabibian, Patrice Francois, Jacques Schrenzel, Farhad Hafezi
PURPOSE: To investigate whether optimized photoactivated chromophore for keratitis-corneal collagen cross-linking (PACK-CXL) treatment settings allow accelerating treatment while maintaining antibacterial efficacy. METHODS: Staphylococcus aureus and Pseudomonas aeruginosa strains were irradiated with ultraviolet-A light of equal fluence but different intensity settings (18 mW/cm² for 5 minutes and 36 mW/cm² for 2.5 minutes). The killing rate was determined by comparing the number of colony-forming units between cross-linked specimens and non-irradiated controls...
December 2014: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/24983827/pack-cxl-defining-cxl-for-infectious-keratitis
#12
EDITORIAL
Farhad Hafezi, J Bradley Randleman
No abstract text is available yet for this article.
July 2014: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/24644053/iontophoresis-transcorneal-delivery-technique-for-transepithelial-corneal-collagen-crosslinking-with-riboflavin-in-a-rabbit-model
#13
Myriam Cassagne, Camille Laurent, Magda Rodrigues, Anne Galinier, Eberhard Spoerl, Stéphane D Galiacy, Vincent Soler, Pierre Fournié, François Malecaze
PURPOSE: We compared an iontophoresis riboflavin delivery technique for transepithelial corneal collagen crosslinking (I-CXL) with a conventional CXL (C-CXL). METHODS: We designed three experimental sets using 152 New Zealand rabbits to study riboflavin application by iontophoresis using charged riboflavin solution (Ricrolin+) with a 1-mA current for 5 minutes. The first set was to compare riboflavin concentration measured by HPLC in corneas after iontophoresis or conventional riboflavin application...
February 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/24576886/collagen-cross-linking-with-photoactivated-riboflavin-pack-cxl-for-the-treatment-of-advanced-infectious-keratitis-with-corneal-melting
#14
RANDOMIZED CONTROLLED TRIAL
Dalia G Said, Mohamed S Elalfy, Zisis Gatzioufas, Ehab S El-Zakzouk, Mansour A Hassan, Mohamed Y Saif, Ahmed A Zaki, Harminder S Dua, Farhad Hafezi
PURPOSE: To investigate the efficacy and safety of corneal collagen cross-linking (CXL) with photoactivated riboflavin (photoactivated chromophore for infectious keratitis [PACK]-CXL) in the management of infectious keratitis with corneal melting. DESIGN: Prospective clinical trial. PARTICIPANTS: Forty eyes from 40 patients with advanced infectious keratitis and coexisting corneal melting. METHODS: Twenty-one patients (21 eyes) underwent PACK-CXL treatment in addition to antimicrobial therapy...
July 2014: Ophthalmology
https://www.readbyqxmd.com/read/24373539/treatment-of-bullous-keratopathy-with-corneal-collagen-cross-linking-in-two-dogs
#15
Simon A Pot, Nicolin S Gallhöfer, Ladina Walser-Reinhardt, Farhad Hafezi, Bernhard M Spiess
OBJECTIVE: Corneal collagen cross-linking with riboflavin and UV-A (CXL) decreases corneal oedema and increases visual acuity in human patients with bullous keratopathy. Presumed mechanisms are an increase in collagen packing density and a reduction in stromal swelling pressure. We present two cases in which CXL was used to treat bullous keratopathy in dogs. PROCEDURES: Four eyes of two dogs with painful bullous keratopathy-induced corneal erosions that were resistant to prior therapy were treated with CXL...
March 2015: Veterinary Ophthalmology
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