Anika M Valk, Jim B D Keijser, Koos P J van Dam, Eileen W Stalman, Luuk Wieske, Maurice Steenhuis, Laura Y L Kummer, Phyllis I Spuls, Marcel W Bekkenk, Annelie H Musters, Nicoline F Post, Angela L Bosma, Barbara Horváth, Dirk-Jan Hijnen, Corine R G Schreurs, Zoé L E van Kempen, Joep Killestein, Adriaan G Volkers, Sander W Tas, Laura Boekel, Gerrit J Wolbink, Sofie Keijzer, Ninotska I L Derksen, Melanie van Deelen, Gerard van Mierlo, Taco W Kuijpers, Filip Eftimov, S Marieke van Ham, Anja Ten Brinke, Theo Rispens
BACKGROUND: The noninflammatory immunoglobulin G4 (IgG4) is linked to tolerance and is unique to humans. Although poorly understood, prolonged antigenic stimulation and IL-4-signaling along the T helper 2-axis may be instrumental in IgG4 class switching. Recently, repeated SARS-CoV-2 mRNA vaccination has been linked to IgG4 skewing. Although widely used immunosuppressive drugs have been shown to only moderately affect humoral responses to SARS-CoV-2 mRNA vaccination, the effect on IgG4 switching has not been investigated...
March 4, 2024: Allergy