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https://www.readbyqxmd.com/read/28633656/children-s-physical-activity-during-a-segmented-school-week-results-from-a-quasi-experimental-education-outside-the-classroom-intervention
#1
Mikkel Bo Schneller, Jasper Schipperijn, Glen Nielsen, Peter Bentsen
BACKGROUND: Movement integration (MI) into traditional classroom teaching is a promising opportunity for children to increase physical activity (PA). Education outside the classroom (EOtC) can be regarded as MI, and has increased children's PA in case studies. The aim of this study is to investigate the effects of EOtC on children's PA by segmenting weekly activity-related behavior into a range of day types and domains. METHODS: In a quasi-experimental design, 33 classes were recruited and participants' PA was objectively measured using accelerometers taped to the lower back...
June 20, 2017: International Journal of Behavioral Nutrition and Physical Activity
https://www.readbyqxmd.com/read/28631643/multidrug-resistant-tuberculosis-detection-and-characterization-of-mutations-in-mycobacterium-tuberculosis-by-genotype-mtbdrplus
#2
Rajneesh Tripathi, Shampa Anupurba
Detection of drug resistance in Mycobacterium tuberculosis by conventional phenotypic drug susceptibility testing methods requires several weeks. Therefore, molecular diagnostic tests for rapid detection of multidrug resistance tuberculosis (MDR-TB) are urgently needed. Early diagnosis helps in initiating optimal treatment which would not only enable cure of an individual patient but also will curb the transmission of drug resistance in the community. Line probe assay (LPA) has shown great promises in the diagnosis of MDR-TB...
April 2017: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/28630602/comparing-the-performance-of-improved-classify-analyze-approaches-for-distal-outcomes-in-latent-profile-analysis
#3
John J Dziak, Bethany C Bray, Jieting Zhang, Minqiang Zhang, Stephanie T Lanza
Several approaches are available for estimating the relationship of latent class membership to distal outcomes in latent profile analysis (LPA). A three-step approach is commonly used, but has problems with estimation bias and confidence interval coverage. Proposed improvements include the correction method of Bolck, Croon, and Hagenaars (BCH; 2004), Vermunt's (2010) maximum likelihood (ML) approach, and the inclusive three-step approach of Bray, Lanza, & Tan (2015). These methods have been studied in the related case of latent class analysis (LCA) with categorical indicators, but not as well studied for LPA with continuous indicators...
October 2016: Methodology: European Journal of Research Methods for the Behavioral & Social Sciences
https://www.readbyqxmd.com/read/28625475/prediction-of-protein-protein-interactions-by-label-propagation-with-protein-evolutionary-and-chemical-information-derived-from-heterogeneous-network
#4
Yu-Ting Wen, Hai-Jun Lei, Zhu-Hong You, Bai-Ying Lei, Xing Chen, Li-Ping Li
Prediction of protein-protein interactions (PPIs) is of great significance. To achieve this, we propose a novel computational method for PPIs prediction based on a similarity network fusion (SNF) model for integrating the physical and chemical properties of proteins. Specifically, the physical and chemical properties of protein are the protein amino acid mutation rate and its hydrophobicity, respectively. The amino acid mutation rate is extracted using a BLOSUM62 matrix, which puts the protein sequence into block substitution matrix...
June 15, 2017: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/28616586/the-autotaxin-lysophosphatidic-acid-pathway-emerges-as-a-therapeutic-target-to-prevent-liver-cancer
#5
Derek J Erstad, Andrew M Tager, Yujin Hoshida, Bryan C Fuchs
Using transcriptome meta-analysis, we recently identified the autotaxin (ATX)-lysophosphatidic acid (LPA) pathway as a regulator of hepatocellular carcinoma (HCC) risk in human cirrhosis patients. Pharmacological targeting of this pathway reduced fibrosis progression and HCC development in animals, identifying ATX-LPA signaling as a novel chemoprevention strategy for cirrhosis and HCC.
2017: Molecular & Cellular Oncology
https://www.readbyqxmd.com/read/28611684/protective-role-for-lpa3-in-cardiac-hypertrophy-induced-by-myocardial-infarction-but-not-by-isoproterenol
#6
Lin Cai, Guangpu Fan, Fang Wang, Si Liu, Tiewei Li, Xiangfeng Cong, Jerold Chun, Xi Chen
Background: We previously reported that lysophosphatidic acid (LPA) promoted cardiomyocyte hypertrophy in vitro via one of its G protein-coupled receptor subtypes, LPA3. In this study, we examined the role of LPA3 in cardiac hypertrophy induced by isoproterenol (ISO) and myocardial infarction. Methods:In vitro, neonatal rat cardiomyocytes (NRCMs) were subjected to LPA3 knocked-down, or pretreated with a β-adrenergic receptor (β-AR) antagonist (propranolol) before LPA/ISO treatment. Cardiomyocyte size and hypertrophic gene (ANP, BNP) mRNA levels were determined...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28609690/what-do-we-know-about-child-abuse-and-neglect-patterns-of-co-occurrence-a-systematic-review-of-profiling-studies-and-recommendations-for-future-research
#7
REVIEW
Agata Debowska, Dominic Willmott, Daniel Boduszek, Adele D Jones
Latent class (LCA) and latent profile (LPA) analysis represent methodological approaches to identify subgroups of maltreated individuals. Although research examining child abuse and neglect (CAN) profiles is still rare, the application of person-centered techniques to clarify CAN types co-occurrence has substantially increased in recent years. Therefore, the aim of the present study was to provide a summary and critical evaluation of the findings of LCA/LPA child maltreatment research to: (a) systemize the current understanding of patterns of maltreatment across populations and (b) elucidate interactive effects of CAN types on psychosocial functioning...
June 10, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/28608045/stabilization-of-structured-populations-via-vector-target-oriented-control
#8
Elena Braverman, Daniel Franco
In contrast with unstructured models, structured discrete population models have been able to fit and predict chaotic experimental data. However, most of the chaos control techniques in the literature have been designed and analyzed in a one-dimensional setting. Here, by introducing target-oriented control for discrete dynamical systems, we prove the possibility to stabilize a chosen state for a wide range of structured population models. The results are illustrated with introducing a control in the celebrated LPA model describing a flour beetle dynamics...
June 12, 2017: Bulletin of Mathematical Biology
https://www.readbyqxmd.com/read/28607954/latent-profile-analysis-of-students-motivation-and-outcomes-in-mathematics-an-organismic-integration-theory-perspective
#9
Chee Keng John Wang, Woon Chia Liu, Youyan Nie, Yen Leng Stefanie Chye, Boon San Coral Lim, Gregory Arief Liem, Eng Guan Tay, Ying-Yi Hong, Chi-Yue Chiu
The purpose of the current study was to identify the motivation profiles at the intraindividual level using a latent profile analyses (LPA) approach. A total of 1151 secondary school students aged 13 to 17 years old from Singapore took part in the study. Using LPA, four distinct motivational profiles were identified based on four motivation regulations. Profile 1 has very low introjected and low autonomous motivation (6% of sample). Profile 2 had high external and identified regulations and very low intrinsic regulation (10%)...
May 2017: Heliyon
https://www.readbyqxmd.com/read/28605269/physical-activity-sedentary-behavior-and-physical-function-in-older-adults-with-multiple-sclerosis
#10
Katie L Cederberg, Robert W Motl, Edward McAuley
Older adults with multiple sclerosis(MS) experience the combined effects of aging and a chronic, disabling neurological disease on physical activity, sedentary behavior, and physical function. OBJECTIVE: This study examined associations among light and moderate-to-vigorous physical activity(LPA and MVPA), sedentary behavior, and physical function in older adults with MS. METHOD: Forty older adults with MS(median age=60 years) who had a median Expanded Disability Status Scale score of 4...
June 12, 2017: Journal of Aging and Physical Activity
https://www.readbyqxmd.com/read/28603982/analysis-of-lysophospholipid-content-in-low-phytate-rice-mutants
#11
Chuan Tong, Yaling Chen, Yuanyuan Tan, Lei Liu, Daniel L E Waters, Terry Rose, Qing-Yao Shu, Jinsong Bao
As a fundamental component of nucleic acids, phospholipids and adenosine triphosphate, phosphorus (P) is critical to all life forms. However, the molecular mechanism of P translocation and distribution in rice grains are still not understood. Here, with the use of five different low phytic acids (lpa) rice mutants, the redistribution in the main P-contained compounds in rice grain, i.e. phytic acid (PA), lysophospholipid (LPL) and inorganic P (Pi) were investigated. The lpa mutants showed a significant decrease in PA and phytate-phosphorus (PA-P) concentration with the concomitant increase in Pi concentration...
June 12, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28599868/a-latent-profile-analysis-on-patient-empowerment-programme-in-a-hong-kong-primary-care-setting
#12
Mike K T Cheung, Sam C C Chan, Anchor T F Hung, Angela Y M Leung, Albert Lee, Frank W K Chan, K L Chung, Peter K K Poon, Chetwyn C H Chan
OBJECTIVE: This study identified the profiles of subgroups of type 2 diabetic (T2DM) patients of the Patient Empowerment Programme (PEP) by different levels of benefits gained in diabetic self-management behaviors, self-efficacy, and health literacy. METHODS: This study adopted a non-experimental repeated-measures design on T2DM patients who joined PEP, using structured questionnaires. Latent profile analysis (LPA) was used to identify patterns of participants' change on the outcome measures...
May 24, 2017: Patient Education and Counseling
https://www.readbyqxmd.com/read/28595938/bifidobacteria-derived-lipoproteins-inhibit-infection-with-coxsackievirus-b4-in-vitro
#13
Khalil Antoine El Kfoury, Marie-Bénédicte Romond, Angelo Scuotto, Enagnon Kazali Alidjinou, Fouad Dabboussi, Monzer Hamze, Ilka Engelmann, Famara Sane, Didier Hober
The aim of the present study was to investigate the potential of bifidobacteria in protecting cells from coxsackievirus B4 (CV-B4) infection. Bifidobacterial screening identified two of five strains that protected human epithelial type 2 (HEp-2) cell viability when bifidobacteria were incubated with viral particles prior to inoculation. In contrast, no effect was shown by incubating HEp-2 cells with bifidobacteria prior to CV-B4 inoculation. Cell wall lipoprotein aggregates (LpAs) secreted by the selected strains were assayed for their antiviral activity...
June 5, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28591560/implications-of-the-lysophosphatidic-acid-signaling-axis-in-liver-cancer
#14
REVIEW
Chiara Lopane, Pasquale Agosti, Isabella Gigante, Carlo Sabbà, Antonio Mazzocca
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death in western countries. The major risk factors for HCC are hepatitis C or B viruses, alcohol and metabolic disorders. The increasing risk of HCC in patients with metabolic disorders (i.e. obesity, diabetes and non-alcoholic steatohepatitis/NASH) regardless of the presence of liver cirrhosis is becoming relevant. Nevertheless, molecular mechanisms linking these risk factors to liver oncogenesis are unclear. This review focuses on the pathogenic role of the lysophosphatidic acid (LPA) pathway in HCC, highlighting the implications of this bioactive phospholipid in liver cancer biology and metabolism and as potential therapeutic target...
June 4, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28588064/autotaxin-lysophosphatidic-acid-lpa3-signaling-at-the-embryo-epithelial-boundary-controls-decidualization-pathways
#15
Shizu Aikawa, Kuniyuki Kano, Asuka Inoue, Jiao Wang, Daisuke Saigusa, Takeshi Nagamatsu, Yasushi Hirota, Tomoyuki Fujii, Soken Tsuchiya, Yoshitaka Taketomi, Yukihiko Sugimoto, Makoto Murakami, Makoto Arita, Makoto Kurano, Hitoshi Ikeda, Yutaka Yatomi, Jerold Chun, Junken Aoki
During pregnancy, up-regulation of heparin-binding (HB-) EGF and cyclooxygenase-2 (COX-2) in the uterine epithelium contributes to decidualization, a series of uterine morphological changes required for placental formation and fetal development. Here, we report a key role for the lipid mediator lysophosphatidic acid (LPA) in decidualization, acting through its G-protein-coupled receptor LPA3 in the uterine epithelium. Knockout of Lpar3 or inhibition of the LPA-producing enzyme autotaxin (ATX) in pregnant mice leads to HB-EGF and COX-2 down-regulation near embryos and attenuates decidual reactions...
June 6, 2017: EMBO Journal
https://www.readbyqxmd.com/read/28586362/fast-and-general-tests-of-genetic-interaction-for-genome-wide-association-studies
#16
Mattias Frånberg, Rona J Strawbridge, Anders Hamsten, Ulf de Faire, Jens Lagergren, Bengt Sennblad
A complex disease has, by definition, multiple genetic causes. In theory, these causes could be identified individually, but their identification will likely benefit from informed use of anticipated interactions between causes. In addition, characterizing and understanding interactions must be considered key to revealing the etiology of any complex disease. Large-scale collaborative efforts are now paving the way for comprehensive studies of interaction. As a consequence, there is a need for methods with a computational efficiency sufficient for modern data sets as well as for improvements of statistical accuracy and power...
June 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28585855/our-great-forgotten-chronic-respiratory-sufferers
#17
María Luisa Bordejé Laguna
Lung’s own properties make that nutritional support, besides covering the requirements can modulate its infl ammatory response. Lung tissue has a low glucose stock. Fatty acids are the main energy producer of type II pneumocytes, which use them in order to form phospholipids, essential for surfactant whose creation and release decrease in acute lung injury (ALI). Glutamine is a good substratum for endocrine cells and type II pneumocytes. Due to high nutritional risk, it is important its assessments in disorders as COPD and acute respiratory distress syndrome (ADRS)...
May 8, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/28584892/coping-profiles-and-subjective-well-being-among-people-living-with-hiv-less-intensive-coping-corresponds-with-better-well-being
#18
Marcin Rzeszutek, Ewa Gruszczyńska, Ewa Firląg-Burkacka
PURPOSE: The aim of this study was to investigate the relationship between coping strategies and subjective well-being (SWB) among people living with HIV (PLWH) using the latent profile analysis (LPA) with control for socio-medical covariates. METHODS: The sample comprised five hundred and thirty people (N = 530) with a confirmed diagnosis of HIV+. The study was cross-sectional with SWB operationalized by satisfaction with life (Satisfaction with Life Scale) and positive and negative affect (PANAS-X)...
June 5, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28582386/cognitive-functioning-at-age-10-years-among-children-born-extremely-preterm-a-latent-profile-approach
#19
Timothy Heeren, Robert M Joseph, Elizabeth N Allred, Thomas M O'Shea, Alan Leviton, Karl C K Kuban
BACKGROUND: School-age children born extremely preterm (EP) are more likely than their term peers to have multiple neurocognitive limitations. We identify subgroups of EP children who share similar profiles on measures of IQ and executive function (EF), and describe the nature and prevalence of cognitive impairment in EP children. METHODS: Based on measures of IQ and EF, subgroups of EP children with common neurocognitive function are identified using latent profile analysis (LPA)...
June 5, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28578726/statistically-derived-subtypes-and-associations-with-cerebrospinal-fluid-and-genetic-biomarkers-in-mild-cognitive-impairment-a-latent-profile-analysis
#20
Joel S Eppig, Emily C Edmonds, Laura Campbell, Mark Sanderson-Cimino, Lisa Delano-Wood, Mark W Bondi
OBJECTIVES: Research demonstrates heterogeneous neuropsychological profiles among individuals with mild cognitive impairment (MCI). However, few studies have included visuoconstructional ability or used latent mixture modeling to statistically identify MCI subtypes. Therefore, we examined whether unique neuropsychological MCI profiles could be ascertained using latent profile analysis (LPA), and subsequently investigated cerebrospinal fluid (CSF) biomarkers, genotype, and longitudinal clinical outcomes between the empirically derived classes...
June 5, 2017: Journal of the International Neuropsychological Society: JINS
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