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https://www.readbyqxmd.com/read/29147686/lipoprotein-a-associated-molecules-are-prominent-components-in-plasma-and-valve-leaflets-in-calcific-aortic-valve-stenosis
#1
Michael Torzewski, Amir Ravandi, Calvin Yeang, Andrea Edel, Rahul Bhindi, Stefan Kath, Laura Twardowski, Jens Schmid, Xiaohong Yang, Ulrich F W Franke, Joseph L Witztum, Sotirios Tsimikas
The LPA gene is the only monogenetic risk factor for calcific aortic valve stenosis (CAVS). Oxidized phospholipids (OxPL) and lysophosphatidic acid generated by autotaxin (ATX) from OxPL are pro-inflammatory. Aortic valve leaflets were categorized pathologically from Both ATX-apoB and ATX-apo(a) were measureable in plasma. Lp(a), autotaxin, OxPL and MDA epitopes progressively increased in immunostaining (p<0.001 for all). Six species of OxPL and LysoPA were identified following extraction from valve leaflets...
June 2017: JACC. Basic to Translational Science
https://www.readbyqxmd.com/read/29145233/prospective-evaluation-of-the-feasibility-safety-and-efficacy-of-cocoon-duct-occluder-for-transcatheter-closure-of-large-patent-ductus-arteriosus-a-single-center-study-with-short-and-medium-term-follow-up-results
#2
Santosh Kumar Sinha, Mahmadula Razi, Rama Niwas Pandey, Prakash Kumar, Vinay Krishna, Mukesh Jitendra Jha, Vikas Mishra, Mohammad Asif, Nasar Abdali, Pradyot Tewari, Ramesh Thakur, Umeshwar Pandey, Chandra Mohan Varma
OBJECTIVE: To evaluate the feasibility, safety, and efficacy of a novel Cocoon Duct Occluder device for the transcatheter closure (TCC) of large patent ductus arteriosus (PDA). METHODS: In this prospective, non-randomized study, consecutive patients with large PDA (narrowest diameter: ≥3.5/4.0 mm in symptomatic/asymptomatic patients, respectively), who underwent TCC with Cocoon Duct Occluder at our institute between November, 2012 and June, 2016 were examined...
November 2017: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/29143699/are-there-distinct-cognitive-and-motivational-sub-groups-of-children-with-adhd
#3
Rikke Lambek, Edmund Sonuga-Barke, Rosemary Tannock, Anne Virring Sørensen, Dorte Damm, Per Hove Thomsen
BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) is proposed to be a neuropsychologically heterogeneous disorder that encompasses two distinct sub-groups, one with executive function (EF) deficits and one with delay aversion (DA). However, such claims have often been based on studies that have operationalized neuropsychological deficits using a categorical approach - using intuitive but rather arbitrary, clinical cut-offs. The current study applied an alternative empirical approach to sub-grouping in ADHD, latent profile analysis (LPA), and attempted to validate emerging subgroups through clinically relevant correlates...
November 16, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/29140899/isotemporal-substitution-of-sedentary-behavior-and-physical-activity-on-function
#4
Nicholas L Lerma, Chi C Cho, Ann M Swartz, Nora E Miller, Kevin G Keenan, Scott J Strath
The amount of time spent in sedentary behaviors (SB) progressively increases with age, while reducing time spent in light (LPA) and moderate-to-vigorous physical activity (MVPA). These trajectories in PA and SB are linked to accelerated reductions in physical functioning. PURPOSE: To examine the association of substituting SB time with LPA and MVPA on physical function in older adults. METHODS: Ninety-one older adults (mean age: 70.7 ± 10.2 yr) wore a hip-mounted accelerometer to measure SB, LPA, and MVPA time...
November 14, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29137260/pathologic-subtype-defined-prognosis-is-dependent-on-both-tumor-stage-and-status-of-oncogenic-driver-mutations-in-lung-adenocarcinoma
#5
Yu Dong, Ying Li, Bo Jin, Jie Zhang, Jinchen Shao, Hong Peng, Shichun Tu, Baohui Han
Previous studies have shown that the prognosis of lung adenocarcinoma is associated with pathological characterization. In this study, we investigated whether pathology-based prognosis was further influenced by both tumor stage and oncogenic driver mutations. To this end, we recruited a cohort of 465 lung adenocarcinoma patients in China. These patients were classified into 6 pathology-defined subtypes i.e., lepidic-predominant adenocarcinoma (LPA), acinar-predominant adenocarcinoma (APA), papillary-predominant adenocarcinoma (PPA), micropapillary-predominant adenocarcinoma (MPA), solid-predominant adenocarcinoma (SPA), and invasive mucinous adenocarcinoma (IMA)...
October 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29134466/glycogen-synthase-kinase-3%C3%AE-mediated-regulation-of-matrix-metalloproteinase-9-and-its-involvement-in-oral-squamous-cell-carcinoma-progression-and-invasion
#6
Kamdeo K Pramanik, Siddavaram Nagini, Abhay K Singh, Prajna Mishra, Tanushree Kashyap, Nidhi Nath, Manzar Alam, Ajay Rana, Rajakishore Mishra
PURPOSE: Oral squamous cell carcinoma (OSCC)-related deaths mainly result from invasion of the tumor cells into local cervical lymph nodes. It has been reported that progressive basement membrane loss promotes the metastatic and invasive capacities of OSCCs. Matrix metalloproteinase-9 (MMP-9) is known to play a central role in tumor progression and invasion. However, the role of MMP-9 in OSCC invasion has so far remained paradoxical and little is known about its regulation. Here, we aimed to assess MMP-9 expression regulation and its activation by glycogen synthase kinase-3β during human OSCC progression and invasion...
November 13, 2017: Cellular Oncology (Dordrecht)
https://www.readbyqxmd.com/read/29129607/polymorphisms-in-hla-c-and-kir-alleles-are-not-associated-with-ham-tsp-risk-in-htlv-1-infected-subjects
#7
Tatiane Assone, Fernanda M Malta, Sonia Bakkour, Leilani Montalvo, Arthur M Paiva, Jerusa Smid, Augusto César Penalva de Oliveira, Fernanda de Toledo Gonçalves, Olinda do Carmo Luiz, Luiz Augusto M Fonseca, Philip J Norris, Jorge Casseb
INTRODUCTION: Several genetic polymorphisms may be related to susceptibility or resistance to viral disease outcomes. Immunological or genetic factors may act as major triggers of the immune pathogenesis of HAM/TSP. This study investigated the association of immune related genetic polymorphisms with viral and immunological markers. METHODS: 247 HTLV-1-infected volunteers, drawn from a larger group of HTLV-infected subjects followed at the Institute of Infectious Diseases "Emilio Ribas" (IIER) for up to 19 years, participated in this study, which ran from June 2011 to July 2016...
November 10, 2017: Virus Research
https://www.readbyqxmd.com/read/29128868/association-of-lpa-variants-with-aortic-stenosis-a-large-scale-study-using-diagnostic-and-procedural-codes-from-electronic-health-records
#8
Hao Yu Chen, Line Dufresne, Hannah Burr, Athithan Ambikkumar, Niko Yasui, Kevin Luk, Dilrini K Ranatunga, Rachel A Whitmer, Mark Lathrop, James C Engert, George Thanassoulis
Importance: Elevated lipoprotein(a) levels are a risk factor for aortic stenosis (AS). However, a large-scale replication of associations between LPA variants and AS, their interactions with risk factors, and the effect of multiple risk alleles is not well established. Objective: To replicate the association between LPA variants with AS and identify subgroups who are at higher risk of developing AS. Design, Setting, and Participants: This case-control study of AS included 44 703 individuals (3469 cases) 55 years or older who were enrolled in the Genetic Epidemiology Research on Aging cohort and who were members of the Kaiser Permanente Northern California health care delivery system...
November 12, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/29128569/lysophosphatidic-acid-receptor-1-is-important-for-intestinal-epithelial-barrier-function-and-susceptibility-to-colitis
#9
Songbai Lin, Yiran Han, Kayte Jenkin, Sei-Jung Lee, Maiko Sasaki, Jan-Michael Klapproth, Peijian He, C Chris Yun
Intestinal epithelial cells form a barrier that is critical in protecting the host from the hostile luminal environment. Previously, we showed that lysophosphatidic acid receptor 1 (LPAR1) regulates proliferation of intestinal epithelial cells such that the absence of LPA1 mitigates epithelial wound healing process. This study provides evidence that LPA1 is important for the maintenance of epithelial barrier integrity. The epithelial permeability, determined by fluorescently labeled dextran flux and transepithelial resistance, is increased in Lpar1(-/-) (Lpa1(-/-)) mouse intestine...
November 8, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/29127342/chemical-analysis-of-morphological-changes-in-lysophosphatidic-acid-treated-ovarian-cancer-cells
#10
Karen A Bailey, Yuliya Klymenko, Peter E Feist, Amanda B Hummon, M Sharon Stack, Zachary D Schultz
Ovarian cancer (OvCa) cells are reported to undergo biochemical changes at the cell surface in response to treatment with lysophosphatidic acid (LPA). Here we use scanning electron microscopy (SEM) and multiplex coherent anti-Stokes Raman scattering (CARS) imaging via supercontinuum excitation to probe morphological changes that result from LPA treatment. SEM images show distinct shedding of microvilli-like features upon treatment with LPA. Analysis of multiplex CARS images can distinguish between molecular components, such as lipids and proteins...
November 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29120750/lysophosphatidate-signaling-the-tumor-microenvironment-s-new-nemesis
#11
Matthew G K Benesch, Zelei Yang, Xiaoyun Tang, Guanmin Meng, David N Brindley
Lysophosphatidate (LPA) is emerging as a potent mediator of cancer progression in the tumor microenvironment. Strategies for targeting LPA signaling have recently entered clinical trials for fibrosis. These therapies have potential to improve the efficacies of existing chemotherapies and radiotherapy by attenuating chronic inflammation, irrespective of diverse mutations within cancer cells.
November 2017: Trends in Cancer
https://www.readbyqxmd.com/read/29120305/correlates-of-accelerometer-assessed-physical-activity-and-sedentary-time-among-adults-with-type-2-diabetes
#12
Nonsikelelo Mathe, Terry Boyle, Fatima Al Sayah, Clark Mundt, Jeff K Vallance, Jeffrey A Johnson, Steven T Johnson
OBJECTIVES: The aims of this study were to describe the volume and patterns of objectively assessed sedentary behaviour, light intensity physical activity (LPA) and moderate-vigorous physical activity (MVPA), and to examine socio-demographic correlates, among adults living with type 2 diabetes. METHODS: Participants (n = 166) wore an accelerometer (Actigraph® GT3X+) for seven consecutive days during waking hours and completed a questionnaire. Physical activity (PA) and sedentary time were described, and multivariable linear regression was used to estimate associations between socio-demographic characteristics and sedentary time and PA...
November 9, 2017: Canadian Journal of Public Health. Revue Canadienne de Santé Publique
https://www.readbyqxmd.com/read/29109088/accelerometer-measured-physical-activity-and-sedentary-behavior-in-relation-to-all-cause-mortality-the-women-s-health-study
#13
I-Min Lee, Eric J Shiroma, Kelly R Evenson, Masamitsu Kamada, Andrea Z LaCroix, Julie E Buring
Physical inactivity is estimated to cause as many deaths globally each year as smoking. Current guidelines recommend ≥150 min/wk of moderate-intensity aerobic physical activity (PA) and muscle-strengthening exercises on ≥2 d/wk.2 These guidelines are based primarily on studies using self-reported moderate- to vigorous-intensity PA (MVPA). Technological developments now enable device assessments of light-intensity PA (LPA) and sedentary behavior, and well-designed studies with such assessments that investigate clinical outcomes are needed for updating current guidelines...
November 6, 2017: Circulation
https://www.readbyqxmd.com/read/29099997/early-metabolome-profiling-and-prognostic-value-in-paraquat-poisoned-patients-based-on-ultra-performance-liquid-chromatography-coupled-to-quadrupole-time-of-flight-mass-spectrometry
#14
Lufeng Hu, Guangliang Hong, Yahui Tang, Xianqin Wang, Congcong Wen, Feiyan Lin, Zhongqiu Lu
Paraquat (PQ) has caused countless deaths throughout the world. There remains no effective treatment for PQ poisoning. Here we study the blood metabolome of PQ-poisoned patient using ultra performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry (UPLC/Q-TOF MS). Patients were divided into groups according blood PQ concentration. Healthy subjects served as controls. Metabolic features were statistically analyzed using multivariate pattern-recognition techniques to identify the most important metabolites...
November 3, 2017: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/29098350/reintervention-burden-and-vessel-growth-after-surgical-reimplantation-of-a-pulmonary-artery-during-childhood
#15
Stephan J Wu, Tacy Downing, Christopher Mascio, Matthew J Gillespie, Yoav Dori, Jonathan J Rome, Andrew C Glatz
Children requiring reimplantation of a branch pulmonary artery (PA) are at risk for postoperative stenosis and impaired growth of the reimplanted PA. Outcomes and risk factors for reintervention and impaired growth are incompletely described. We reviewed data on patients who underwent reimplantation of a branch PA between 1/1/99 and 5/1/15 at a single center. The primary outcome was reintervention to treat postoperative stenosis. The secondary outcome was "catch-up" growth (faster diameter growth of the affected PA compared with the unaffected PA from the preoperative to follow-up measurements...
November 2, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/29094653/seasonal-changes-in-physical-activity-during-school-recess-and-lunchtime-among-australian-children
#16
Nicola D Ridgers, Jo Salmon, Anna Timperio
This study examined how children's physical activity levels during recess and lunchtime and the contribution of recess and lunchtime to daily physical activity differed across seasons. Three hundred and twenty-six children aged 8-11 years from Australia participated. Physical activity was measured every 15-seconds using hip-mounted ActiGraph accelerometers for 7 consecutive days during the winter (n = 246), spring (n = 211), summer (n = 161) and autumn terms (n = 139). Data were collected 2012-2013...
November 2, 2017: Journal of Sports Sciences
https://www.readbyqxmd.com/read/29092769/using-accelerometers-to-characterize-recovery-after-surgery-in-children
#17
Hassan Mk Ghomrawi, Lauren M Baumann, Soyang Kwon, Ferdynand Hebal, Grace Hsiung, Kibileri Williams, Molly Reimann, Christine Stake, Emilie K Johnson, Fizan Abdullah
BACKGROUND: Assessment of recovery after surgery in children remains highly subjective. However, advances in wearable technology present an opportunity for clinicians to have an objective assessment of postoperative recovery. The aims of this pilot study are to: (1) evaluate acceptability of accelerometer use in pediatric surgical patients, (2) use accelerometer data to characterize the recovery trajectory of physical activity, and (3) determine if postoperative adverse events are associated with a decrease in physical activity...
October 6, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29090513/objectively-measured-physical-activity-and-sedentary-behavior-in-successful-weight-loss-maintainers
#18
Danielle M Ostendorf, Kate Lyden, Zhaoxing Pan, Holly R Wyatt, James O Hill, Edward L Melanson, Victoria A Catenacci
OBJECTIVE: The objective of this study was to compare patterns of objectively measured moderate-to-vigorous physical activity (MVPA, ≥ 3.00 metabolic equivalents [METs]), light-intensity physical activity (LPA, 1.50-2.99 METs), and sedentary behavior (SB, < 1.50 METs) in successful weight loss maintainers (WLMs), normal weight controls (NC), and controls with overweight/obesity (OC). METHODS: Participants (18-65 y) were recruited in three groups: WLM (maintaining ≥ 13...
November 1, 2017: Obesity
https://www.readbyqxmd.com/read/29089933/curaxin-cbl0100-blocks-hiv-1-replication-and-reactivation-through-inhibition-of-viral-transcriptional-elongation
#19
Maxime J Jean, Tsuyoshi Hayashi, Huachao Huang, Justin Brennan, Sydney Simpson, Andrei Purmal, Katerina Gurova, Michael C Keefer, James J Kobie, Netty G Santoso, Jian Zhu
Despite combination antiretroviral therapy (cART), acquired immunodeficiency syndrome (AIDS), predominantly caused by the human immunodeficiency virus type 1 (HIV-1), remains incurable. The barrier to a cure lies in the virus' ability to establish a latent infection in HIV/AIDS patients. Unsurprisingly, efforts for a sterilizing cure have focused on the "shock and kill" strategy using latency-reversing agents (LRAs) to complement cART in order to eliminate these latent reservoirs. However, this method faces numerous challenges...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29081100/-the-clinical-study-on-the-correlation-of-lysophosphatidic-acid-and-vascular-endotheli-growth-factor-and-endothelin-in-serum-of-pneumoconiosis
#20
L J Mao, Y L Zhang, C C Cong, L Guan, S Q Li, J Y Zhao
Objective: To explore the role of lysophosphatidic acid, vascular endothelial growth facor and endothelin in the pathogenesis of pulmonary fibrosis in coal workers'pneumoconiosis patients, the relationship of lysophosphatidic acid, VEGF and ET in serum was studied. Methods: Sixty two pneumoconiosis patients were selected as cases group, which included 23 cases of stage Ⅰ, 25 cases of stageⅡand 14 cases of stageⅢ. Twenty workers were selected as dust exposure group who exposed to coal dust for more than 2 years and had not been diagnosed as pneumoconiosis...
July 20, 2017: Chinese Journal of Industrial Hygiene and Occupational Diseases
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