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https://www.readbyqxmd.com/read/28214851/lysophosphatidic-acid-promotes-epithelial-to-mesenchymal-transition-in-ovarian-cancer-cells-by-repressing-sirt1
#1
Upasana Ray, Sib Sankar Roy, Shreya Roy Chowdhury
BACKGROUND/AIMS: Epithelial-to-mesenchymal transition (EMT) plays an essential role in the transition from early to invasive phenotype, however the underlying mechanisms still remain elusive. Herein, we propose a mechanism through which the class-III deacetylase SIRT1 regulates EMT in ovarian cancer (OC) cells. METHODS: Expression analysis was performed using Q-PCR, western blot, immunofluorescence and fluorescence-IHC study. Matrigel invasion assay was used for the invasion study...
February 14, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28213024/sanitizer-efficacy-in-preventing-cross-contamination-of-heads-of-lettuce-during-retail-crisping
#2
Yangjin Jung, Hyein Jang, Mengqi Guo, Jingwen Gao, Karl R Matthews
This study was conducted to provide information regarding mitigation of cross-contamination through the use of sanitizer during crisping at retail outlets. Seven non-inoculated heads and one inoculated head (≈5 log CFU/g) of lettuce were placed into commercial sink filled with 76 L of tap water (TW), electrolyzed water (EW, free chlorine: 43 ± 6 ppm), lactic acid and phosphoric acid-based sanitizer (LPA, pH 2.89), or citric acid-based sanitizer (CA, pH 2.78) and soaked for 5 min. Two subsequent batches (eight non-inoculated heads per batch) were soaked in the same solution...
June 2017: Food Microbiology
https://www.readbyqxmd.com/read/28206976/lipid-and-alzheimer-s-disease-genes-associated-with-healthy-aging-and-longevity-in-healthy-oldest-old
#3
Lauren C Tindale, Stephen Leach, John J Spinelli, Angela R Brooks-Wilson
Several studies have found that long-lived individuals do not appear to carry lower numbers of common disease-associated variants than ordinary people; it has been hypothesized that they may instead carry protective variants. An intriguing type of protective variant is buffering variants that protect against variants that have deleterious effects. We genotyped 18 variants in 15 genes related to longevity or healthy aging that had been previously reported as having a gene-gene interaction or buffering effect...
February 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28205098/enhanced-cellular-functions-through-induction-of-lpa2-by-cisplatin-in-fibrosarcoma-ht1080-cells
#4
Kaede Takahashi, Kaori Fukushima, Nobuyuki Fukushima, Kanya Honoki, Toshifumi Tsujiuchi
Lysophosphatidic acid (LPA) is a simple biophysical lipid which interacts with at least six subtypes of G protein-coupled LPA receptors (LPA1-LPA6). In cancer cells, LPA signaling via LPA receptors is involved in the regulation of malignant properties, such as cell growth, motility, and invasion. The aim of this study was to assess whether LPA receptors regulate cellular functions of fibrosarcoma cells treated with anticancer drug. HT1080 cells were maintained by the stepwise treatment of cisplatin (CDDP) at a range of 0...
February 15, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28192736/evidence-of-the-dissociative-ptsd-subtype-a-systematic-literature-review-of-latent-class-and-profile-analytic-studies-of-ptsd
#5
REVIEW
Maj Hansen, Jana Ross, Cherie Armour
BACKGROUND: The dissociative PTSD (D-PTSD) subtype was first introduced into the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) in 2013. Prior to this, studies using latent profile analysis (LPA) or latent class analysis (LCA), began to provide support for the D-PTSD construct and associated risk factors. This research is important, because dissociative symptoms in the context of PTSD may potentially interfere with treatment course or outcome. The aims of the present study were twofold: to systematically review the LCA and LPA studies investigating support for the D-PTSD construct; and to review the associated research on the risk factors or covariates of D-PTSD in the identified studies...
February 7, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28187102/physical-activity-behavior-predicts-endogenous-pain-modulation-in-older-adults
#6
Kelly M Naugle, Thomas Ohlman, Keith E Naugle, Zachary A Riley, NiCole R Keith
Older adults compared with younger adults are characterized by greater endogenous pain facilitation and a reduced capacity to endogenously inhibit pain, potentially placing them at a greater risk for chronic pain. Previous research suggests that higher levels of self-reported physical activity are associated with more effective pain inhibition and less pain facilitation on quantitative sensory tests in healthy adults. However, no studies have directly tested the relationship between physical activity behavior and pain modulatory function in older adults...
March 2017: Pain
https://www.readbyqxmd.com/read/28186980/diet-induced-obesity-links-to-er-positive-breast-cancer-progression-via-lpa-pkd-1-cd36-signaling-mediated-microvascular-remodeling
#7
Liuyi Dong, Ye Yuan, Cynthia Opansky, Yiliang Chen, Irene Aguilera-Barrantes, Shiyong Wu, Rong Yuan, Qi Cao, Yee Chung Cheng, Daisy Sahoo, Roy L Silverstein, Bin Ren
Obesity increases cancer risk including breast cancer (BC). However, the direct regulatory mechanisms by which obesity promotes BC progression remain largely unknown. We show that lysophosphatidic acid/protein kinase D1 (LPA/PKD-1)-CD36 signaling is a bona fide breast cancer promoter via stimulating microvascular remodeling in chronic diet-induced obesity (DIO). We observed that the growth of an estrogen receptor (ER) positive breast cancer was markedly increased when compared to the lean control, and specifically accompanied by increased microvascular remodeling in a syngeneic BC model in female DIO mice...
February 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/28185536/a-new-anti-aging-lysophosphatidic-acid-from-arabidopsis-thaliana
#8
Yujuan Sun, Yanhui Wang, Guangfa Wang, Lan Xiang, Jianhua Qi
BACKGROUND: Aging is a risk factor of age-related diseases. With the increasing number of patients, serious consequences, and heavy economic burden, demands for drugs used to treat age-related diseases have increased. As such, anti-aging substances should be isolated to develop drugs for the prevention and treatment of age-related diseases. METHODS: In this study, a methanol extract of immature Arabidopsis thaliana seeds with coat was separated by using a K6001 yeast bioassay system...
February 9, 2017: Medicinal Chemistry
https://www.readbyqxmd.com/read/28185214/prevention-of-cardiovascular-complications-in-patients-with-lp-a-hyperlipoproteinemia-and-progressive-cardiovascular-disease-by-long-term-lipoprotein-apheresis-according-to-german-national-guidelines
#9
Reinhard Klingel, Andreas Heibges, Cordula Fassbender
Lipoprotein(a) (Lp(a)) is an independent cardiovascular risk factor playing a causal role for atherosclerotic cardiovascular disease (CVD). Lipoprotein apheresis (LA) is a safe well-tolerated outpatient treatment to lower LDL-C and Lp(a) by 60-70%, and is the ultimate escalating therapeutic option in patients with hyperlipoproteinemias (HLP) involving LDL particles. Major therapeutic effect of LA is preventing cardiovascular events. Lp(a)-HLP associated with progressive CVD has been approved as indication for regular LA in Germany since 2008...
February 9, 2017: Clinical Research in Cardiology Supplements
https://www.readbyqxmd.com/read/28176353/lysophosphatidic-acid-induced-itch-is-mediated-by-signaling-of-lpa5-receptor-phospholipase-d-and-trpa1-trpv1
#10
Hiroki Kittaka, Kunitoshi Uchida, Naomi Fukuta, Makoto Tominaga
Intractable and continuous itch sensations often accompany diseases such as atopic dermatitis, neurogenic lesions, uremia and cholestasis. Lysophosphatidic acid (LPA) is an itch mediator found in cholestatic itch patients and it induces acute itch and pain in the experimental rodent models. However, the molecular mechanism by which LPA activates peripheral sensory neurons remains unknown. In this study, we used a cheek injection method in mice to reveal that LPA induced itch-related behaviors but not pain-related behaviors...
February 8, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28168694/the-optimization-of-electrophoresis-on-a-glass-microfluidic-chip-and-its-application-in-forensic-science
#11
Jun P Han, Jing Sun, Le Wang, Peng Liu, Bin Zhuang, Lei Zhao, Yao Liu, Cai X Li
Microfluidic chips offer significant speed, cost, and sensitivity advantages, but numerous parameters must be optimized to provide microchip electrophoresis detection. Experiments were conducted to study the factors, including sieving matrices (the concentration and type), surface modification, analysis temperature, and electric field strengths, which all impact the effectiveness of microchip electrophoresis detection of DNA samples. Our results showed that the best resolution for ssDNA was observed using 4...
February 7, 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/28167353/genetic-risk-analysis-of-coronary-artery-disease-in-pakistani-subjects-using-a-genetic-risk-score-of-21-variants
#12
Saleem Ullah Shahid, Shabana, Jackie A Cooper, Katherine E Beaney, Kawah Li, Abdul Rehman, Steve E Humphries
BACKGROUND AND AIMS: Conventional coronary artery disease (CAD) risk factors like age, gender, blood lipids, hypertension and smoking have been the basis of CAD risk prediction algorithms, but provide only modest discrimination. Genetic risk score (GRS) may provide improved discrimination over and above conventional risk factors. Here we analyzed the genetic risk of CAD in subjects from Pakistan, using a GRS of 21 variants in 18 genes and examined whether the GRS is associated with blood lipid levels...
January 22, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28165241/rational-design-of-autotaxin-inhibitors-by-structural-evolution-of-endogenous-modulators
#13
Willem-Jan Keune, Frances Potjewyd, Tatjana Heidebrecht, Fernando Salgado-Polo, Simon J F Macdonald, Lakshman Chelvarajan, Ahmed Abdel Latif, Sony Soman, Andrew J Morris, Allan J B Watson, Craig Jamieson, Anastassis Perrakis
Autotaxin produces the bioactive lipid lysophosphatidic acid (LPA) and is a drug target of considerable interest for numerous pathologies. We report the expedient, structure-guided evolution of weak physiological allosteric inhibitors (bile salts) into potent competitive Autotaxin inhibitors that do not interact with the catalytic site. Functional data confirms that our lead compound attenuates LPA mediated signaling in cells and reduces LPA synthesis in vivo, providing a promising natural product derived scaffold for drug discovery...
February 16, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28157379/cre-and-sre-mediate-lpa-induced-ccn1-transcription-in-mouse-aortic-smooth-muscle-cells
#14
Quanlin Dou, Feng Hao, Longsheng Sun, Xuemin Xu, Mei-Zhen Cui
Lysophosphatidic acid (LPA), one component of oxidized low-density lipoprotein (ox-LDL), is a potent bioactive phospholipid. Our recent data reveal that LPA induces matricellular protein CCN1 (also known as Cyr61) expression in aortic smooth muscle cells (SMCs) and that CCN1 bridges LPA and integrin signaling pathways leading to SMC migration. Whether and how LPA regulates the transcriptional machinery of the CCN1 gene are unknown. In this study, we found that LPA markedly induces CCN1 mRNA expression in SMCs...
December 17, 2016: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28153018/physical-activity-levels-objectively-measured-among-older-adults-a-population-based-study-in-a-southern-city-of-brazil
#15
Virgílio Viana Ramires, Fernando César Wehrmeister, Andrea Wendt Böhm, Leony Galliano, Ulf Ekelund, Soren Brage, Inácio Crochemore Mohnsam da Silva
BACKGROUND: Low levels of physical activity are currently observed in all age groups around the world. Among older adults physical activity is even lower, potentially influencing quality of life, incidence of diseases and premature mortality. The aim of this study was to describe objectively measured physical activity levels among older adults residents in a Southern city of Brazil. METHODS: A population-based study was carried out including people aged 60+ years living in the urban area of Pelotas...
February 2, 2017: International Journal of Behavioral Nutrition and Physical Activity
https://www.readbyqxmd.com/read/28151690/temporal-and-bidirectional-associations-between-physical-activity-and-sleep-in-primary-school-aged-children
#16
Grace E Vincent, Lisa M Barnett, David R Lubans, Jo Salmon, Anna Timperio, Nicola D Ridgers
The directionality of the relationship between children's physical activity and sleep is unclear. This study examined the temporal and bidirectional associations between objectively measured physical activity, energy expenditure, and sleep in primary school-aged children. A subgroup of children (n = 65, aged 8-11 years) from the Fitness, Activity and Skills Testing Study conducted in Melbourne, Australia, had their sleep and physical activity assessed using the SenseWear Pro Armband for 8 consecutive days. Outcome measures included time spent in light-intensity physical activiy (LPA), moderate- to vigorous-intensity physical activity (MVPA), activity energy expenditure (AEE), time in bed, total sleep time, and sleep efficiency...
November 3, 2016: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28142081/heterogeneity-in-patterns-of-dsm-5-posttraumatic-stress-disorder-and-depression-symptoms-latent-profile-analyses
#17
Ateka A Contractor, Michelle E Roley-Roberts, Susan Lagdon, Cherie Armour
BACKGROUND: Posttraumatic stress disorder (PTSD) and depression co-occur frequently following the experience of potentially traumatizing events (PTE; Morina et al., 2013). A person-centered approach to discern heterogeneous patterns of such co-occurring symptoms is recommended (Galatzer-Levy and Bryant, 2013). We assessed heterogeneity in PTSD and depression symptomatology; and subsequently assessed relations between class membership with psychopathology constructs (alcohol use, distress tolerance, dissociative experiences)...
January 23, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28126668/insomnia-before-and-after-childbirth-the-risk-of-developing-postpartum-pain-a-longitudinal-population-based-study
#18
Børge Sivertsen, Keith J Petrie, Jens Christoffer Skogen, Mari Hysing, Malin Eberhard-Gran
OBJECTIVE: To examine if insomnia before and after childbirth predicts the development of postpartum bodily pain. METHODS: This study is part of a longitudinal cohort study, the Akershus Birth Cohort Study, which targeted all women giving birth at Akershus University Hospital in Norway. The current sample is comprised of 1480 women who participated at all three time points, yielding a participation rate of 32% of the 4662 women who originally consented to participate...
January 19, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28126468/autotaxin-lysophosphatidic-acid-receptor-signalling-regulates-hepatitis-c-virus-replication
#19
Michelle J Farquhar, Isla S Humphreys, Simon A Rudge, Garrick K Wilson, Bishnupriya Bhattacharya, Maria Ciaccia, Ke Hu, Qifeng Zhang, Laurent Mailly, Gary M Reynolds, Margaret Aschcroft, Peter Balfe, Thomas F Baumert, Stephanie Roessler, Michael J O Wakelam, Jane A McKeating
BACKGROUND AND AIMS: Chronic hepatitis C is a global health problem with an estimated 170 million HCV infected individuals at risk of progressive liver disease and hepatocellular carcinoma (HCC). Autotaxin (ATX) is a phospholipase with diverse roles in physiological and pathological processes including inflammation and oncogenesis. Clinical studies have reported increased ATX expression in chronic hepatitis C, however, the pathways regulating ATX and its role in the viral life cycle are not well understood...
January 23, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28121016/regression-equations-for-calculation-of-z-scores-for-echocardiographic-measurements-of-right-heart-structures-in-healthy-han-chinese-children
#20
Shan-Shan Wang, Yu-Qi Zhang, Shu-Bao Chen, Guo-Ying Huang, Hong-Yan Zhang, Zhi-Fang Zhang, Lan-Ping Wu, Wen-Jing Hong, Rong Shen, Yi-Qing Liu, Jun-Xue Zhu
OBJECTIVE: Clinical decision making in children with congenital and acquired heart disease relies on measurements of cardiac structures using two-dimensional echocardiography. We aimed to establish z-score regression equations for right heart structures in healthy Chinese Han children. METHODS: Two-dimensional and M-mode echocardiography was performed in 515 patients. We measured the dimensions of the pulmonary valve annulus (PVA), main pulmonary artery (MPA), left pulmonary artery (LPA), right pulmonary artery (RPA), right ventricular outflow tract at end-diastole (RVOTd) and at end-systole (RVOTs), tricuspid valve annulus (TVA), right ventricular inflow tract at end-diastole (RVIDd) and at end-systole (RVIDs), and right atrium (RA)...
January 25, 2017: Journal of Clinical Ultrasound: JCU
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