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Chondrocyte transplant

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https://www.readbyqxmd.com/read/28639852/osteochondritis-dissecans-etiology-pathology-and-imaging-with-a-special-focus-on-the-knee-joint
#1
Juergen Bruns, Mathias Werner, Christian Habermann
This article is a review of the current understanding of the etiology, pathogenesis, and how to diagnose and treat knee osteochondritis dissecans (OCD) followed by an analysis of and outcomes of the treatments available. OCD is seen in children and adolescents with open growth plates (juvenile OCD) and adults with closed growth plates (adult OCD). The etiology of OCD lesions remains unclear and is characterized by an aseptic necrosis in the subchondral bone area. Mechanical factors seem to play an important role...
June 1, 2017: Cartilage
https://www.readbyqxmd.com/read/28632455/joint-preservation-techniques-in-orthopaedic-surgery
#2
Philip J York, Frank B Wydra, Matthew E Belton, Armando F Vidal
CONTEXT: With increasing life expectancy, there is growing demand for preservation of native articular cartilage to delay joint arthroplasties, especially in younger, active patients. Damage to the hyaline cartilage of a joint has a limited intrinsic capacity to heal. This can lead to accelerated degeneration of the joint and early-onset osteoarthritis. Treatment in the past was limited, however, and surgical treatment options continue to evolve that may allow restoration of the natural biology of the articular cartilage...
June 1, 2017: Sports Health
https://www.readbyqxmd.com/read/28629066/glucosamine-modified-polyethylene-glycol-hydrogel-mediated-chondrogenic-differentiation-of-human-mesenchymal-stem-cells
#3
Hang Yao, Jingchen Xue, Qunfang Wang, Renjian Xie, Weichang Li, Sa Liu, Jinglei Cai, Dajiang Qin, Dong-An Wang, Li Ren
Glucosamine (GA) is an important cartilage matrix precursor for the glycosaminoglycan biochemical synthesis, and has positive effects on cartilage regeneration, particularly in osteoarthritis therapy. However, it has not been used as a bioactive group in scaffolds for cartilage repair widely. In this study, we synthesized modified polyethylene glycol (PEG) hydrogel with glucosamine and then encapsulated human bone mesenchymal stem cells (hBMSCs) in the hydrogel to induce the differentiation of hBMSCs into chondrocytes in three-dimensional culture...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28620621/matrix-assisted-autologous-chondrocyte-transplantation-in-the-knee-a-systematic-review-of-mid-to-long-term-clinical-outcomes
#4
REVIEW
Hayden B Schuette, Matthew J Kraeutler, Eric C McCarty
BACKGROUND: Matrix-assisted autologous chondrocyte transplantation (MACT) is a surgical treatment option for articular cartilage lesions of the knee joint. PURPOSE: To investigate mid- to long-term clinical outcomes of MACT in the patellofemoral (PF) and tibiofemoral (TF) joints. STUDY DESIGN: Systematic review; Level of evidence, 4. METHODS: A systematic review was performed by searching PubMed, Embase, and the Cochrane Library to find studies evaluating minimum 5-year clinical outcomes of patients undergoing MACT in the knee joint...
June 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28594507/management-of-osteochondral-lesions-of-the-talus
#5
Michael Isiah Sandlin, Timothy P Charlton, Cyrus E Taghavi, Eric Giza
Management strategies for symptomatic osteochondral lesions of the talus are primarily surgical. Treatment options for symptomatic osteochondral lesions of the talus most commonly include bone marrow stimulation techniques, osteochondral autograft transplantation, osteochondral allograft transplantation, autologous chondrocyte implantation, matrix-induced autologous chondrocyte implantation, and particulated juvenile articular cartilage. The selection of the most appropriate treatment option should be based on the specifics of a talar lesion, in particular, lesion size...
February 15, 2017: Instructional Course Lectures
https://www.readbyqxmd.com/read/28589877/arthroscopic-treatment-of-chondral-defects-in-the-hip-amic-maci-microfragmented-adipose-tissue-transplantation-matt-and-other-options
#6
Eugenio Jannelli, Andrea Fontana
Chondral lesions are currently considered in the hip as a consequence of trauma, osteonecrosis, dysplasia, labral tears, loose bodies, dislocation, previous slipped capital femoral epiphysis and Femoro-Acetabular-Impingement (FAI). The management of chondral lesions is debated and several techniques are described. The physical examination must be carefully performed, followed by radiographs and magnetic resonance imaging (MRI). Differential diagnosis with other pathologies must be considered. Debridement is indicated in patients younger than 50 years with a chondropathy of 1st or 2nd degree...
2017: SICOT-J
https://www.readbyqxmd.com/read/28576023/bioengineered-porous-composite-curcumin-silk-scaffolds-for-cartilage-regeneration
#7
Do Kyung Kim, Jeong In Kim, Bo Ra Sim, Gilson Khang
Articular cartilage repair is a challenge due to its limited self-repair capacity. Cartilage tissue engineering supports to overcome following injuries or degenerative diseases. Herein, we fabricated the scaffold composed of curcumin and silk fibroin as an appropriate clinical replacement for defected cartilage. The scaffolds were designed to have adequate pore size and mechanical strength for cartilage repair. Cell proliferation, sulfated glycosaminoglycan (sGAG) content and mRNA expression analysis indicated that chondrocytes remained viable and showed its growth ability in the curcumin/silk scaffolds...
September 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28575639/matrix-production-affects-mri-outcomes-after-matrix-associated-autologous-chondrocyte-transplantation-in-the-knee
#8
Christian Albrecht, Carla-Antonia Reuter, David Stelzeneder, Lukas Zak, Brigitte Tichy, Sylvia Nürnberger, Sandra Boesmueller, Stefan Marlovits, Siegfried Trattnig, Stefan Hajdu, Silke Aldrian
BACKGROUND: Matrix-associated autologous chondrocyte transplantation (MACT) has been an effective therapy for large, full-thickness cartilage lesions for years. However, little is known about how graft maturation is affected by characteristics of transplanted chondrocytes. PURPOSE: To investigate the influence of gene expression of chondrocytes at the time of transplantation on MRI outcomes up to 2 years after MACT. STUDY DESIGN: Case series; Level of evidence, 4...
June 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28574571/roles-of-macrophage-migration-inhibitory-factor-in-cartilage-tissue-engineering
#9
Yuko Fujihara, Atsuhiko Hikita, Tsuyoshi Takato, Kazuto Hoshi
To obtain stable outcomes in regenerative medicine, understanding and controlling immunological responses in transplanted tissues are of great importance. In our previous study, auricular chondrocytes in tissue-engineered cartilage transplanted in mice were shown to express immunological factors, including macrophage migration inhibitory factor (MIF). Since MIF exerts pleiotropic functions, in this study, we examined the roles of MIF in cartilage regenerative medicine. We made tissue-engineered cartilage consisting of auricular chondrocytes of C57BL/6J mouse, atellocollagen gel and a PLLA scaffold, and transplanted the construct subcutaneously in a syngeneic manner...
June 2, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28551498/nasal-chondrocytes-as-a-neural-crest-derived-cell-source-for-regenerative-medicine
#10
REVIEW
Karoliina Pelttari, Marcus Mumme, Andrea Barbero, Ivan Martin
Cells deriving from neural crest are generally acknowledged during embryonic development for their multipotency and plasticity, accounting for their capacity to generate various cell and tissue types even across germ layers. At least partial preservation of some of these properties in adulthood makes neural crest derived cells of large interest for regenerative purposes. Chondrocytes from fully mature nasal septum cartilage in adults are also derivatives of neural crest cells and were recently demonstrated to be able not only to maintain functionality across serial cloning, as surrogate self-renewal test, but also to respond and adapt to heterotopic transplantation sites...
May 25, 2017: Current Opinion in Biotechnology
https://www.readbyqxmd.com/read/28531813/immunomodulatory-function-of-whole-human-umbilical-cord-derived-mesenchymal-stem-cells
#11
Hao Zhang, Yanling Tao, Haihui Liu, Saisai Ren, Bin Zhang, Hu Chen
Bone marrow derived mesenchymal stem cells (MSCs) play a critical role in immune modulation. However, immunomodulatory function of whole human umbilical cord derived mesenchymal stem cells (UC-MSCs) remains unclear. In this study, UC-MSCs were separated from whole umbilical cord using a single enzyme digestion. UC-MSCs (CD73(+), CD90(+), CD105(+), and CD34(-), CD45(-), HLA-DR(-)) were differentiated into adipocytes, osteocytes and chondrocytes in vitro under specific stimulatory environments. UC-MSCs suppressed umbilical cord blood lymphocyte proliferation stimulated by mitogen, and ELISA showed that the secretion of INF-γ was downregulated, and the secretion of IL-4 was upregulated, with CD8(+) T cells markedly decreased and CD4(+) T cells changed lightly...
May 19, 2017: Molecular Immunology
https://www.readbyqxmd.com/read/28530850/fresh-osteochondral-allograft-transplantation-is-graft-storage-time-associated-with-clinical-outcomes-and-graft-survivorship
#12
Kenneth J Schmidt, Luís E Tírico, Julie C McCauley, William D Bugbee
BACKGROUND: Regulatory concerns and the popularity of fresh osteochondral allograft (OCA) transplantation have led to a need for prolonged viable storage of osteochondral grafts. Tissue culture media allow a longer storage time but lead to chondrocyte death within the tissue. The long-term clinical consequence of prolonged storage is unknown. HYPOTHESIS: Patients transplanted with OCAs with a shorter storage time would have lower failure rates and better clinical outcomes than those transplanted with OCAs with prolonged storage...
May 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28528696/reprogramming-of-dermal-fibroblasts-into-osteo-chondrogenic-cells-with-elevated-osteogenic-potency-by-defined-transcription-factors
#13
Yinxiang Wang, Ming-Hoi Wu, May Pui Lai Cheung, Mai Har Sham, Haruhiko Akiyama, Danny Chan, Kathryn S E Cheah, Martin Cheung
Recent studies using defined transcription factors to convert skin fibroblasts into chondrocytes have raised the question of whether osteo-chondroprogenitors expressing SOX9 and RUNX2 could also be generated during the course of the reprogramming process. Here, we demonstrated that doxycycline-inducible expression of reprogramming factors (KLF4 [K] and c-MYC [M]) for 6 days were sufficient to convert murine fibroblasts into SOX9(+)/RUNX2(+) cellular aggregates and together with SOX9 (S) promoted the conversion efficiency when cultured in a defined stem cell medium, mTeSR...
June 6, 2017: Stem Cell Reports
https://www.readbyqxmd.com/read/28516106/a-cost-effectiveness-analysis-of-surgical-treatment-modalities-for-chondral-lesions-of-the-knee-microfracture-osteochondral-autograft-transplantation-and-autologous-chondrocyte-implantation
#14
REVIEW
John B Schrock, Matthew J Kraeutler, Darby A Houck, Matthew B McQueen, Eric C McCarty
BACKGROUND: Numerous surgical options exist to treat chondral lesions in the knee, including microfracture (MFx), osteochondral autograft transplantation (OAT), first-generation autologous chondrocyte implantation (ACI-1), and next-generation ACI (ACI-2). PURPOSE: To compare the cost-effectiveness of MFx, OAT, and ACI-1. The secondary purpose of this study was to compare the functional outcomes of MFx, OAT, ACI-1, and ACI-2. STUDY DESIGN: Systematic review; Level of evidence, 2...
May 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28515001/in-vitro-extracellular-matrix-accumulation-of-nasal-and-articular-chondrocytes-for-intervertebral-disc-repair
#15
S Vedicherla, C T Buckley
Chondrocyte based regenerative therapies for intervertebral disc repair such as Autologous Disc Cell Transplantation (ADCT, CODON) and allogeneic juvenile chondrocyte implantation (NuQu(®), ISTO Technologies) have demonstrated good outcomes in clinical trials. However concerns remain with the supply demand reconciliation and issues surrounding immunoreactivity which exist for allogeneic-type technologies. The use of stem cells is challenging due to high growth factor requirements, regulatory barriers and differentiation towards a stable phenotype...
May 8, 2017: Tissue & Cell
https://www.readbyqxmd.com/read/28507946/conditioned-medium-of-wharton-s-jelly-derived-stem-cells-can-enhance-the-cartilage-specific-genes-expression-by-chondrocytes-in-monolayer-and-mass-culture-systems
#16
Maryam Hassan Famian, Soheila Montazer Saheb, Azadeh Montaseri
Purpose: Mesenchymal stem cells (MSCs) have been introduced for cell therapy strategies in osteoarthritis (OA). Despite of their capacity for differentiation into chondrocyte, there are some evidences about their life-threatening problem after transplantation. So, some researchers shifted on the application of stem cells conditioned medium. The goal of this study is to evaluate whether Wharton's jelly derived stem cell conditioned medium (WJSCs-CM) can enhance the gene expression profile by chondrocytes in monolayer and mass culture systems...
April 2017: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28471326/chondrocyte-cell-sheet-transplantation-for-treating-monoiodoacetate-induced-arthritis-in-rats
#17
Seiju Hayashi, Naosuke Kamei, Yasunari Ikuta, Ryo Shimizu, Masakazu Ishikawa, Nobuo Adachi, Mitsuo Ochi
Engineered cell sheets that are fabricated by using temperature-responsive culture dishes are now available in the clinical setting. Engineered chondrocyte cell sheets are used in clinical trials for treating focal articular cartilage defects. However, the efficacy of engineered chondrocyte cell sheets for treating diffusely degenerated articular cartilage remains unknown. In the present study, we assessed the utility of engineered chondrocyte cell sheets for treating diffusely degenerated articular cartilage in a monoiodoacetate (MIA)-induced arthritis animal model...
June 2017: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/28447574/optimized-longitudinal-monitoring-of-stem-cell-grafts-in-mouse-brain-using-a-novel-bioluminescent-near-infrared-fluorescent-fusion-reporter
#18
Laura Mezzanotte, Juvita Delancy Iljas, Ivo Que, Alan Chan, Eric Kaijzel, Rob Hoeben, Clemens Löwik
<p>Biodistribution and fate of transplanted stem cells via longitudinal monitoring has been successfully achievedin the last decade using optical imaging. However, sensitive longitudinal imaging of transplanted stem cells in deep tissue like the brain remains challenging not only due to low light penetration but because of other factors such as low or inferior expression levels of optical reporters in stem cells and stem cell death after transplantation. Here we describe an optimized imaging protocol for sensitive long term monitoring of human bone marrow derived mesenchymal stem cells (hMSCs) expressing a novel bioluminescent/near infrared fluorescent (NIRF) fusion reporter transplanted in mouse brain cortex...
April 26, 2017: Cell Transplantation
https://www.readbyqxmd.com/read/28423287/microfracture-versus-autologous-chondrocyte-implantation-for-articular-cartilage-lesions-in-the-knee-a-systematic-review-of-5-year-outcomes
#19
Matthew J Kraeutler, John W Belk, Justin M Purcell, Eric C McCarty
BACKGROUND: Microfracture (MFx) and autologous chondrocyte implantation (ACI) are 2 surgical treatment options used to treat articular cartilage injuries of the knee joint. PURPOSE: To compare the midterm to long-term clinical outcomes of MFx versus ACI for focal chondral defects of the knee. STUDY DESIGN: Systematic review. METHODS: A systematic review was performed by searching PubMed, the Cochrane Library, and Embase to locate studies (level of evidence I-III) comparing the minimum average 5-year clinical outcomes of patients undergoing MFx versus ACI...
April 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28406876/cartilage-restoration-techniques-for-the-patellofemoral-joint
#20
Robert H Brophy, Robert D Wojahn, Joseph D Lamplot
Symptomatic osteochondral lesions of the patellofemoral joint are clinically challenging to manage because of the limited healing potential of articular cartilage; the complex morphology of the patellofemoral joint; the heterogeneity of the articular surface between patients; and high stresses across the joint, which can be altered by malalignment, tilt, or maltracking. Indications for surgery include traumatic lesions, osteochondritis dissecans, and high-grade chondromalacia in association with persistent pain despite a course of nonsurgical management...
May 2017: Journal of the American Academy of Orthopaedic Surgeons
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