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Global increased permeability syndrome

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https://www.readbyqxmd.com/read/27617199/causality-of-small-and-large-intestinal-microbiota-in-weight-regulation-and-insulin-resistance
#1
Torsten P M Scheithauer, Geesje M Dallinga-Thie, Willem M de Vos, Max Nieuwdorp, Daniël H van Raalte
OBJECTIVE: The twin pandemics of obesity and Type 2 diabetes (T2D) are a global challenge for health care systems. Changes in the environment, behavior, diet, and lifestyle during the last decades are considered the major causes. A Western diet, which is rich in saturated fat and simple sugars, may lead to changes in gut microbial composition and physiology, which have recently been linked to the development of metabolic diseases. METHODS: We will discuss evidence that demonstrates the influence of the small and large intestinal microbiota on weight regulation and the development of insulin resistance, based on literature search...
September 2016: Molecular Metabolism
https://www.readbyqxmd.com/read/27430014/food-additive-p-80-impacts-mouse-gut-microbiota-promoting-intestinal-inflammation-obesity-and-liver-dysfunction
#2
Ratnesh Kumar Singh, Nolan Wheildon, Seiichi Ishikawa
The increasing prevalence of obesity has emerged as one of the most important global public health issue. The change to the human microbiome as a result of changes in the quality and quantity of food intake over the past several decades has been implicated in the development of obesity and metabolic syndrome. We administered polysorbate-80 to mice via gavage. The researchers monitor liver noninvasively using a bioluminescence imaging. For the liver dysfunction we measure the liver enzymes and PAS stain on liver, electron microscopy liver mitochondria...
2016: SOJ Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/27025140/-volemic-status-and-the-phasic-approach-to-the-treatment-of-critical-states-new-opportunites-and-prospects
#3
REVIEW
V V Kuz'kov, E V Fot, A A Smjotkin, K M Lebedinskij, M Yu Kirov
Current guidelines suggest that an early and aggressive fluid therapy is the best rescue approach to restore and preserve cardiac index, organ function and decrease the risk of multiple organ failure in shock of various origin. However, escala- tion of fluid resuscitation is a double-edged sword often associated with reperfusion, glicocalyx injury, capillary leakage, delayed weight gain and heperhydration. The body of evidences demons trates that an excessive fluid load in ICUpatient with global increased permeability syndrome, and, particularly, in ARDS and acute kidney injury can be devastating, particularly when guided with central venous pressure...
November 2015: Anesteziologiia i Reanimatologiia
https://www.readbyqxmd.com/read/26177130/altered-microcirculation-in-septic-shock
#4
REVIEW
L Ratiani, M Gamkrelidze, E Khuchua, T Khutsishvili, N Intskirveli, K Vardosanidze
Retrospective data analysis of microcirculation in septic shock was conducted. Sepsis is characterized by a severe microvascular dysfunction that persists despite fluid resuscitation and leads to multi-organ failure even after normalization of hemodynamics in response to fluid resuscitation, vasopressors and the treatment of infection. Several clinical studies suggest that microcirculatory alterations in severe sepsis are stronger predictors of outcome than global hemodynamic variables. Microvascular dysfunction under septic shock is related to: increased capillary permeability that manifests as a breakdown of the microvascular endothelial barrier (factors which may contribute to capillary leak syndrome include endogenous proinflammatory cytokines, angiopoietin 2, vascular endothelial growth factor); arteriolar hyporesponsiveness to vasoconstrictors and vasodilators, the loss of adrenergic sensitivity and tone of smooth muscle cells lining the arterioles; loss of the anti-adhesive function of endothelial surfaces; decreased density of perfused capillaries (due to several contributing factors: decreased deformability of erythrocytes and neutrophils; activation of the clotting cascade with fibrin deposition and the formation of microthrombi; dysfunction of vascular autoregulatory mechanisms by nitric oxide; enhanced functional arteriovenous shunting of the microcirculation)...
July 2015: Georgian Medical News
https://www.readbyqxmd.com/read/25803843/opposite-phenotypes-of-muscle-strength-and-locomotor-function-in-mouse-models-of-partial-trisomy-and-monosomy-21-for-the-proximal-hspa13-app-region
#5
Véronique Brault, Arnaud Duchon, Caroline Romestaing, Ignasi Sahun, Stéphanie Pothion, Mona Karout, Christelle Borel, Doulaye Dembele, Jean-Charles Bizot, Nadia Messaddeq, Andrew J Sharp, Damien Roussel, Stylianos E Antonarakis, Mara Dierssen, Yann Hérault
The trisomy of human chromosome 21 (Hsa21), which causes Down syndrome (DS), is the most common viable human aneuploidy. In contrast to trisomy, the complete monosomy (M21) of Hsa21 is lethal, and only partial monosomy or mosaic monosomy of Hsa21 is seen. Both conditions lead to variable physiological abnormalities with constant intellectual disability, locomotor deficits, and altered muscle tone. To search for dosage-sensitive genes involved in DS and M21 phenotypes, we created two new mouse models: the Ts3Yah carrying a tandem duplication and the Ms3Yah carrying a deletion of the Hspa13-App interval syntenic with 21q11...
March 2015: PLoS Genetics
https://www.readbyqxmd.com/read/25520837/global-end-diastolic-volume-is-an-important-contributor-to-increased-extravascular-lung-water-in-patients-with-acute-lung-injury-and-acuterespiratory-distress-syndrome-a-multicenter-observational-study
#6
Tadashi Kaneko, Yoshikatsu Kawamura, Tsuyoshi Maekawa, Takashi Tagami, Toshiaki Nakamura, Nobuyuki Saito, Yasuhide Kitazawa, Hiroyasu Ishikura, Manabu Sugita, Kazuo Okuchi, Hiroshi Rinka, Akihiro Watanabe, Yoichi Kase, Shigeki Kushimoto, Hiroo Izumino, Takashi Kanemura, Kazuhide Yoshikawa, Hiroyuki Takahashi, Takayuki Irahara, Teruo Sakamoto, Yuichi Kuroki, Yasuhiko Taira, Ryutarou Seo, Junko Yamaguchi, Makoto Takatori
BACKGROUND: Extravascular lung water (EVLW), as measured by the thermodilution method, reflects the extent of pulmonary edema. Currently, there are no clinically effective treatments for preventing increases in pulmonary vascular permeability, a hallmark of lung pathophysiology, in patients with acute lung injury/acute respiratory distress syndrome (ALI/ARDS). In this study, we examined the contributions of hemodynamic and osmolarity factors, for which appropriate interventions are expected in critical care, to EVLW in patients with ALI/ARDS...
2014: Journal of Intensive Care
https://www.readbyqxmd.com/read/25476433/-pulse-indicator-continuous-cardiac-output-measurement-guided-treatment-aids-two-pediatric-patients-with-severe-acute-pancreatitis-complicated-with-acute-respiratory-distress-syndrome
#7
Weiyuan Yan, Lijie Wang
OBJECTIVE: To evaluate the clinical value of the pulse indicator continuous cardiac output (PiCCO) system in patients with severe acute pancreatitis (SAP) complicated with acute respiratory distress syndrome (ARDS). METHOD: Two cases of SAP with ARDS were monitored using PiCCO during comprehensive management in the Pediatric Intensive Care Unit (PICU) of Shengjing Hospital, China Medical University. To guide fluid management, the cardiac index (CI) was measured to assess cardiac function, the global end-diastolic volume index (GEDVI) was used to evaluate cardiac preload, and the extravascular lung water index (EVLWI) was used to evaluate the pulmonary edema...
September 2014: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/25370987/biological-effect-of-ketamine-in-urothelial-cell-lines-and-global-gene-expression-analysis-in-the-bladders-of-ketamine%C3%A2-injected-mice
#8
Cheng-Huang Shen, Shou-Tsung Wang, Ying-Ray Lee, Shiau-Yuan Liu, Yi-Zhen Li, Jiann-Der Wu, Yi-Ju Chen, Yi-Wen Liu
Ketamine is used clinically for anesthesia but is also abused as a recreational drug. Previously, it has been established that ketamine‑induced bladder interstitial cystitis is a common syndrome in ketamine‑abusing individuals. As the mechanisms underlying ketamine‑induced cystitis have yet to be revealed, the present study investigated the effect of ketamine on human urothelial cell lines and utilized a ketamine‑injected mouse model to identify ketamine‑induced changes in gene expression in mice bladders...
February 2015: Molecular Medicine Reports
https://www.readbyqxmd.com/read/25298950/transfusion-support-in-patients-with-dengue-fever
#9
REVIEW
Paramjit Kaur, Gagandeep Kaur
Dengue fever has emerged as a global public health problem in the recent decades. The clinical spectrum of the disease ranges from dengue fever to dengue hemorrhagic fever and dengue shock syndrome. The disease is characterized by increased capillary permeability, thrombocytopenia and coagulopathy. Thrombocytopenia with hemorrhagic manifestations warrants platelet transfusions. There is lack of evidence-based guidelines for transfusion support in patients with dengue fever. This contributes to inappropriate use of blood components and blood centers constantly face the challenge of inventory management during dengue outbreaks...
September 2014: International Journal of Applied and Basic Medical Research
https://www.readbyqxmd.com/read/25293626/role-of-permissive-hypotension-hypertonic-resuscitation-and-the-global-increased-permeability-syndrome-in-patients-with-severe-hemorrhage-adjuncts-to-damage-control-resuscitation-to-prevent-intra-abdominal-hypertension
#10
REVIEW
Juan C Duchesne, Lewis J Kaplan, Zsolt J Balogh, Manu L N G Malbrain
Secondary intra-abdominal hypertension (IAH) and abdominal compartment syndrome (ACS) are closely related to fluid resuscitation. IAH causes major deterioration of the cardiac function by affecting preload, contractility and afterload. The aim of this review is to discuss the different interactions between IAH, ACS and resuscitation, and to explore a new hypothesis with regard to damage control resuscitation, permissive hypotension and global increased permeability syndrome. Review of the relevant literature via PubMed search...
2015: Anaesthesiology Intensive Therapy
https://www.readbyqxmd.com/read/25014067/activation-of-hypoxia-inducible-factor-1%C3%AE-in-type-2-alveolar-epithelial-cell-is-a-major-driver-of-acute-inflammation-following-lung-contusion
#11
Madathilparambil V Suresh, Sadeesh Kumar Ramakrishnan, Bivin Thomas, David Machado-Aranda, Yu Bi, Nicholas Talarico, Erik Anderson, Shah M Yatrik, Krishnan Raghavendran
OBJECTIVE: Lung contusion is a major risk factor for the development of acute respiratory distress syndrome. Hypoxia-inducible factor-1α is the primary transcription factor that is responsible for regulating the cellular response to changes in oxygen tension. We set to determine if hypoxia-inducible factor-1α plays a role in the pathogenesis of acute inflammatory response and injury in lung contusion. DESIGN: Nonlethal closed-chest unilateral lung contusion was induced in a hypoxia reporter mouse model and type 2 cell-specific hypoxia-inducible factor-1α conditional knockout mice...
October 2014: Critical Care Medicine
https://www.readbyqxmd.com/read/24316107/discovery-and-development-of-antisecretory-drugs-for-treating-diarrheal-diseases
#12
REVIEW
Jay R Thiagarajah, Eun-A Ko, Lukmanee Tradtrantip, Mark Donowitz, A S Verkman
Diarrheal diseases constitute a significant global health burden and are a major cause of childhood mortality and morbidity. Treatment of diarrheal disease has centered on the replacement of fluid and electrolyte losses using oral rehydration solutions. Although oral rehydration solutions have been highly successful, significant mortality and morbidity due to diarrheal disease remains. Secretory diarrheas, such as those caused by bacterial and viral enterotoxins, result from activation of cyclic nucleotide and/or Ca(2+) signaling pathways in intestinal epithelial cells, enterocytes, which increase the permeability of Cl(-) channels at the lumen-facing membrane...
February 2014: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/24305068/role-of-cognitive-parameters-in-dengue-hemorrhagic-fever-and-dengue-shock-syndrome
#13
REVIEW
Jih-Jin Tsai, Kulkanya Chokephaibulkit, Po-Chih Chen, Li-Teh Liu, Hui-Mien Hsiao, Yu-Chih Lo, Guey Chuen Perng
Dengue is becoming recognized as one of the most important vector-borne human diseases. It is predominant in tropical and subtropical zones but its geographical distribution is progressively expanding, making it an escalating global health problem of today. Dengue presents with spectrum of clinical manifestations, ranging from asymptomatic, undifferentiated mild fever, dengue fever (DF), to dengue hemorrhagic fever (DHF) with or without shock (DSS), a life-threatening illness characterized by plasma leakage due to increased vascular permeability...
2013: Journal of Biomedical Science
https://www.readbyqxmd.com/read/24187406/toll-like-receptor-status-in-obesity-and-metabolic-syndrome-a-translational-perspective
#14
REVIEW
Ishwarlal Jialal, Harmeet Kaur, Sridevi Devaraj
CONTEXT: The prevalence of both obesity and metabolic syndrome (MetS) is increasing at alarming rates globally. Both predispose to diabetes, cardiovascular disease, fatty liver disease, obstructive sleep apnea, and certain cancers. Understanding the mechanisms contributing to increased cardiometabolic risk in obesity and MetS is of utmost importance. EVIDENCE ACQUISITION: For this review, we performed a detailed literature search on PubMed of all publications related to Toll-like receptors (TLRs) and obesity and MetS for the last 20 years...
January 2014: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/23856907/challenges-for-the-formulation-of-a-universal-vaccine-against-dengue
#15
REVIEW
Kulkanya Chokephaibulkit, Guey Chuen Perng
Dengue is rapidly becoming a disease of an escalating global public health concern. The disease is a vector-borne disease, transmitted by the bite of an Aedes spp. mosquito. Dynamic clinical manifestations, ranging from asymptomatic, flu-like febrile illness, dengue fever (DF) to dengue hemorrhagic fever (DHF) with or without dengue shock syndrome (DSS), make the disease one of the most challenging to diagnose and treat. DF is a self-limited illness, while DHF/DSS, characterized by plasma leakage resulting from an increased vascular permeability, can have severe consequences, including death...
May 2013: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/23593167/focused-examination-of-the-intestinal-epithelium-reveals-transcriptional-signatures-consistent-with-disturbances-in-enterocyte-maturation-and-differentiation-during-the-course-of-siv-infection
#16
Mahesh Mohan, Deepak Kaushal, Pyone P Aye, Xavier Alvarez, Ronald S Veazey, Andrew A Lackner
The Gastrointestinal (GI) tract plays a pivotal role in AIDS pathogenesis as it is the primary site for viral transmission, replication and CD4(+) T cell destruction. Accordingly, GI disease (enteropathy) has become a well-known complication and a driver of AIDS progression. To better understand the molecular mechanisms underlying GI disease we analyzed global gene expression profiles sequentially in the intestinal epithelium of the same animals before SIV infection and at 21 and 90 days post infection (DPI)...
2013: PloS One
https://www.readbyqxmd.com/read/22873410/fluid-management-in-critically-ill-patients-the-role-of-extravascular-lung-water-abdominal-hypertension-capillary-leak-and-fluid-balance
#17
Colin Cordemans, Inneke De Laet, Niels Van Regenmortel, Karen Schoonheydt, Hilde Dits, Wolfgang Huber, Manu Lng Malbrain
INTRODUCTION: Capillary leak in critically ill patients leads to interstitial edema. Fluid overload is independently associated with poor prognosis. Bedside measurement of intra-abdominal pressure (IAP), extravascular lung water index (EVLWI), fluid balance, and capillary leak index (CLI) may provide a valuable prognostic tool in mechanically ventilated patients. METHODS: We performed an observational study of 123 mechanically ventilated patients with extended hemodynamic monitoring, analyzing process-of-care variables for the first week of ICU admission...
2012: Annals of Intensive Care
https://www.readbyqxmd.com/read/22766716/force-control-of-endothelium-permeability-in-mechanically-stressed-pulmonary-micro-vascular-endothelial-cells
#18
Bin Wang, Adam Caluch, Redouane Fodil, Sophie Féréol, Patricia Zadigue, Gabriel Pelle, Bruno Louis, Daniel Isabey
Mechanical factors play a key role in the pathogenesis of Acute Respiratory Distress Syndrome (ARDS) and Ventilator-Induced Lung Injury (VILI) as contributing to alveolo-capillary barrier dysfunction. This study aims at elucidating the role of the cytoskeleton (CSK) and cell-matrix adhesion system in the stressed endothelium and more precisely in the loss of integrity of the endothelial barrier. We purposely develop a cellular model made of a monolayer of confluent Human Pulmonary Microvascular Endothelial Cells (HPMVECs) whose cytoskeleton (CSK) is directly exposed to sustained cyclic mechanical stress for 1 and 2 h...
2012: Bio-medical Materials and Engineering
https://www.readbyqxmd.com/read/22591361/hiv-1-gp120-and-drugs-of-abuse-interactions-in-the-central-nervous-system
#19
REVIEW
Peter S Silverstein, Ankit Shah, James Weemhoff, Santosh Kumar, D P Singh, Anil Kumar
HIV-1 infection is a global public health problem with more than 34 million people living with HIV infection. Although great strides have been made in treating this epidemic with therapeutic agents, the increase in patient life span has been coincident with an increase in the prevalence of HIV-associated neurocognitive disorders (HAND). HAND is thought to result from the neurotoxic effects of viral proteins that are shed from HIV-infected microglial cells. One of the primary neurotoxins responsible for this effect is the HIV-1 glycoprotein gp120...
July 2012: Current HIV Research
https://www.readbyqxmd.com/read/22154245/detection-of-a-procoagulable-state-during-controlled-ovarian-hyperstimulation-for-in-vitro-fertilization-with-global-assays-of-haemostasis
#20
Eli Westerlund, Peter Henriksson, Håkan Wallén, Outi Hovatta, Kenny Rodriguez Wallberg, Alexandra Antovic
INTRODUCTION: Controlled ovarian hyperstimulation during in vitro fertilization (IVF) causes profound increments in serum estradiol which may influence haemostasis and the ovarian hyperstimulation syndrome. In the present study we investigated the effect of the standard IVF-stimulation protocol on coagulation and fibrinolysis as assessed by different global haemostatic assays. MATERIALS AND METHODS: Blood samples were drawn from 31 women during the down-regulation phase when estradiol secretion is inhibited, and before egg retrieval, i...
October 2012: Thrombosis Research
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