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https://www.readbyqxmd.com/read/29679936/controversies-in-monitoring-metastatic-breast-cancer-during-systemic-treatment-results-of-a-gim-gruppo-italiano-mammella-survey
#1
Bonotto Marta, Basile Debora, Gerratana Lorenzo, Pelizzari Giacomo, Bartoletti Michele, Vitale Maria Grazia, Fanotto Valentina, Lisanti Camilla, Mansutti Mauro, Minisini Alessandro Marco, Aprile Giuseppe, De Laurentiis Michele, Montemurro Filippo, Del Mastro Lucia, Puglisi Fabio
BACKGROUND: The optimal strategy for monitoring metastatic breast cancer (M-MBC) is unclear. Nevertheless, M-MBC influences patient's quality of life and it affects the use of resources in terms of both drugs and diagnostic exam prescription. We aim to disclose oncologists' approach on M-MBC, identifying controversial areas. METHODS: An anonymous online survey was conducted among GIM members who, based on their on-field experience, shared their own method for M-MBC planning...
April 18, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29679890/evaluation-and-determination-of-soil-remediation-schemes-using-a-modified-ahp-model-and-its-application-in-a-contaminated-coking-plant
#2
Xingang Li, Jia Li, Hong Sui, Lin He, Xingtao Cao, Yonghong Li
Soil remediation has been considered as one of the most difficult pollution treatment tasks due to its high complexity in contaminants, geological conditions, usage, urgency, etc. The diversity in remediation technologies further makes quick selection of suitable remediation schemes much tougher even the site investigation has been done. Herein, a sustainable decision support hierarchical model has been developed to select, evaluate and determine preferred soil remediation schemes comprehensively based on modified analytic hierarchy process (MAHP)...
April 6, 2018: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29679849/global-analysis-of-advanced-metastatic-breast-cancer-decade-report-2005-2015
#3
Fatima Cardoso, Danielle Spence, Shirley Mertz, Dian Corneliussen-James, Kimberly Sabelko, Julie Gralow, Maria-João Cardoso, Fedro Peccatori, Diego Paonessa, Ann Benares, Naomi Sakurai, Marc Beishon, Sarah-Jane Barker, Musa Mayer
Approximately 0.5 million people worldwide die from metastatic breast cancer (mBC) every year. This manuscript provides an overview on the status of mBC in several regions of the world, highlighting the gaps in care, resources, and support available for patients with mBC. Primary research was conducted in 2015 and 2016, comprising four global qualitative and quantitative surveys of approximately 15,000 individuals in 34 countries. Secondary research was conducted using literature reviews of peer-reviewed publications, patient survey reports, and media or online articles...
April 18, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29679824/extended-producer-responsibility-and-corporate-performance-effects-of-environmental-regulation-and-environmental-strategy
#4
Benhong Peng, Yu Tu, Ehsan Elahi, Guo Wei
While contemporary manufacturing technologies stimulate the industrial revolution and promote the rapidly changing global economy, it has caused enormous environmental negative externalities and managing the industrial waste remains a primary challenge, especially for fast developing countries such as China. Though existing studies explored the influence of Extended Producer Responsibility (EPR) legislations on environmental externalities, only fewer researches aimed at policy issues. Particularly, the relationship among environmental regulations, environmental strategies and corporate performance in the EPR system has not been deeply investigated...
April 18, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29679822/advanced-strategies-to-improve-nitrification-process-in-sequencing-batch-reactors-a-review
#5
REVIEW
Francisco Jaramillo, Marcos Orchard, Carlos Muñoz, Mauricio Zamorano, Christian Antileo
The optimization of biological nitrogen removal (BNR) in sequencing batch reactors has become the aim of researchers worldwide in order to increase efficiency and reduce energy and operating costs. This research has focused on the nitrification phase as the limiting reaction rate of BNR. This paper analyzes different strategies and discusses different tools such as: factors for achieving partial nitrification, real-time control and monitoring for detecting characteristic patterns of nitrification/denitrification as end-points, use of modeling based on activated sludge models, and the use of data-driven modeling for estimating variables that cannot be easily measured experimentally or online...
April 18, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29679810/the-cost-effectiveness-of-seven-behavioural-interventions-to-prevent-drug-misuse-in-vulnerable-populations
#6
Becky Pennington, Brendan Collins, Simon Leigh, Antony P Martin, Lesley Owen, Alastair Fischer, Harry Sumnall, Geoff Bates
BACKGROUND: The National Institute for Health and Care Excellence (NICE) developed a guideline on drug misuse prevention in vulnerable populations. Part of the guideline development process involved evaluating cost-effectiveness and determining which interventions represented good value for money. METHODS: Economic models were developed for seven interventions which aimed to prevent drug use in vulnerable populations. The models compared the costs (to the health and crime sectors) and health benefits (in quality-adjusted life years (QALYs)) of each intervention and its comparator...
April 18, 2018: International Journal on Drug Policy
https://www.readbyqxmd.com/read/29679714/population-genetics-phylogenomics-and-hybrid-speciation-of-juglans-in-china-determined-from-whole-chloroplast-genomes-transcriptomes-and-genotyping-by-sequencing-gbs
#7
Peng Zhao, Hui-Juan Zhou, Daniel Potter, Yi-Heng Hu, Xiao-Jia Feng, Meng Dang, Li Feng, Saman Zulfiqar, Wen-Zhe Liu, Guifang Zhao, Keith Woeste
Genomic data are a powerful tool for elucidating the processes involved in the evolution and divergence of species. The speciation and phylogenetic relationships among Chinese Juglans remain unclear. Here, we used results from phylogenomic and population genetic analyses, transcriptomics, Genotyping-By-Sequencing (GBS), and whole chloroplast genomes (Cp genome) data to infer processes of lineage formation among the five native Chinese species of the walnut genus (Juglans, Juglandaceae), a widespread, economically important group...
April 18, 2018: Molecular Phylogenetics and Evolution
https://www.readbyqxmd.com/read/29679625/nutrition-therapy-within-and-beyond-gestational-diabetes
#8
REVIEW
Teri L Hernandez, Archana Mande, Linda A Barbour
With the global rising prevalence of gestational diabetes (GDM), an adaptable, economical approach to nutrition therapy that effectively controls maternal glycemia while promoting normal fetal growth will have far-reaching implications. The conventional focus has been to rigidly limit all types of carbohydrate. While controlling glucose, this approach fosters maternal anxiety and is a primary barrier to adherence. Many mothers substitute fat for carbohydrate, which may unintentionally enhance lipolysis, promote elevated free fatty acids (FFA), and worsen maternal insulin resistance (IR)...
April 18, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29679621/the-global-burden-of-hyperglycemia-in-pregnancy-trends-from-studies-in-the-last-decade
#9
REVIEW
Bhuvan Martin, David A Sacks
Concurrent with the rise in obesity, global rates of diabetes are increasing at alarming rates in both developed and developing nations. As these conditions become more prevalent among women of reproductive age, rates of hyperglycemia in pregnancy (HIP) are also increasing. HIP is associated with many immediate perinatal complications which affect both maternal and fetal/neonatal health, as well as with more long term complications. Long term complications include an increase in chronic non-communicable diseases in both mother and offspring, therefore affecting future generations...
April 18, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29679594/design-and-synthesis-of-a-new-peptide-derived-from-fasciola-gigantica-cathepsin-l1-with-potential-application-in-serodiagnosis-of-fascioliasis
#10
Behnam Meshgi, Fatemeh Jalousian, Saeid Fathi, Zahra Jahani
Fascioliasis is a global parasitic disease that affects domestic animals and causes considerable economic losses in the process of domestic animal breeding in endemic regions. The cause of the disease involves a liver trematode of the genus Fasciola, which secretes materials into a host's body (mainly proteins) in order to protect it from the host's immune system. These materials can be involved in the migration, growth, and nutrition of the parasite. Among the expressive proteins of Fasciola, proteases have been introduced as the appropriate targets for diagnosis, treatment, and vaccination against parasites...
April 18, 2018: Experimental Parasitology
https://www.readbyqxmd.com/read/29679545/the-impact-of-ocular-tuberculosis-on-vision-after-two-months-of-intensive-therapy
#11
Suzana Batista Vereza de Oliveira, Ângelo Ferreira Passos, David Jamil Hadad, Lorena Zbyszynski, Pedro Sousa de Almeida Júnior, Luiz Guilherme Schmidt Castellani, Reynaldo Dietze, Moisés Palaci
Tuberculosis (TB) is an infectious disease of global importance with major economic and social burden accounting for 25% of all avoidable deaths in developing countries. Extrapulmonary involvement may occur either in association with clinically apparent pulmonary tuberculosis or in isolation. This cross-sectional descriptive study aimed to evaluate the impact of ocular tuberculosis in visual acuity at baseline and after two months of intensive anti-tuberculous therapy. A sample of 133 pulmonary TB patients, seven disseminated TB, and three pleural TB patients was evaluated...
April 18, 2018: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29679316/cost-effectiveness-of-human-papillomavirus-vaccination-for-men-who-have-sex-with-men-reviewing-the-available-evidence
#12
Didik Setiawan, Abrham Wondimu, KohJun Ong, Albert Jan van Hoek, Maarten J Postma
BACKGROUND: Men who have sex with men require special attention for human papillomavirus vaccination given elevated infection risks and the development of, in particular, anal cancer. OBJECTIVE: Our purpose was to review the cost effectiveness of human papillomavirus vaccination for both currently vaccine-eligible and non-eligible individuals, particularly the men-who-have-sex-with-men population, and synthesize the available evidence. METHODS: We systematically searched for published articles in two main databases (PubMed and EMBASE)...
April 20, 2018: PharmacoEconomics
https://www.readbyqxmd.com/read/29679298/future-of-treatment-for-nonalcoholic-steatohepatitis-can-the-use-of-safe-evidence-based-clinically-proven-supplements-provide-the-answer-to-the-unmet-need
#13
REVIEW
Yaron Ilan
The epidemic of nonalcoholic fatty liver disease (NAFLD) has created a real and unmet therapeutic need. The long regulatory pathway and the focus on selected subsets of patients with established and advanced disease are some of the current obstacles to providing effective treatment for the majority of NAFLD patients. The complexity of the disease pathogenesis, which involves multiple mechanisms, requires targeting of more than one pathway or a combination-based therapy. Although the drugs being developed may prevent progression to cirrhosis or may decrease negative liver outcomes, their effects on cardiometabolic health and cancer prevention remain unknown...
April 20, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29679272/steam-jet-mill-a-prospective-solution-to-industrial-exhaust-steam-and-solid-waste
#14
Mingxing Zhang, Haiyan Chen
Bulk industrial solid wastes occupy a lot of our resources and release large amounts of toxic and hazardous substances to the surrounding environment, demanding innovative strategies for grinding, classification, collection, and recycling for economically ultrafine powder. A new technology for grinding, classification, collection, and recycling solid waste is proposed, using the superheated steam produced from the industrial exhaust steam to disperse, grind, classify, and collect the industrial solid waste...
April 20, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29679243/factors-associated-with-the-separate-and-concurrent-experiences-of-food-and-housing-insecurity-among-women-living-with-hiv-in-canada
#15
Carmen H Logie, Ying Wang, Natania Marcus, Angela Kaida, Nadia O'Brien, Val Nicholson, Kath Webster, Tracey Conway, Alexandra de Pokomandy, Mona Loutfy
People living with HIV are disproportionately affected by food and housing insecurity. We assessed factors associated with experiencing food and/or housing insecurity among women living with HIV (WLHIV) in Canada. In our sample of WLHIV (N = 1403) 65% reported an income less than $20,000 per year. Most (78.69%) participants reported food and/or housing insecurity: 27.16% reported experiencing food insecurity alone, 14.26% reported housing insecurity alone, and 37.28% reported experiencing food and housing insecurity concurrently...
April 20, 2018: AIDS and Behavior
https://www.readbyqxmd.com/read/29679164/the-effect-of-a-school-based-intervention-on-physical-activity-and-well-being-a-non-randomised-controlled-trial-with-children-of-low-socio-economic-status
#16
Stephen Shannon, Deirdre Brennan, Donncha Hanna, Zoe Younger, Jessica Hassan, Gavin Breslin
BACKGROUND: Self-determination theory (SDT) has been used to predict children's physical activity and well-being. However, few school-based SDT intervention studies have been conducted, and no research exists with children of low socio-economic status (SES). Therefore, SDT-derived needs-supportive teaching techniques informed the design and analyses of the Healthy Choices Programme (HCP). The aim was to determine if the HCP could enhance moderate-to-vigorous physical activity (MVPA) and well-being among children of low SES through increasing autonomy-support, needs satisfaction and intrinsic motivation...
April 20, 2018: Sports Medicine—Open
https://www.readbyqxmd.com/read/29679129/-operative-treatment-of-degenerative-diseases-of-the-lumbar-spine
#17
REVIEW
M Czabanka, C Thomé, F Ringel, B Meyer, S-O Eicker, V Rohde, M Stoffel, P Vajkoczy
BACKGROUND: Degenerative diseases of the lumbar spine and associated lower back pain represent a major epidemiological and health-related economic challenge. A distinction is made between specific and unspecific lower back pain. In specific lower back pain lumbar disc herniation and spinal canal stenosis with or without associated segment instability are among the most frequent pathologies. Diverse conservative and operative strategies for treatment of these diseases are available. OBJECTIVES: The aim of this article is to present an overview of current data and an evidence-based assessment of the possible forms of treatment...
April 20, 2018: Der Nervenarzt
https://www.readbyqxmd.com/read/29678994/can-exercise-delay-transition-to-active-therapy-in-men-with-low-grade-prostate-cancer-a-multicentre-randomised-controlled-trial
#18
Daniel A Galvão, Dickon Hayne, Mark Frydenberg, Suzanne K Chambers, Dennis R Taaffe, Nigel Spry, Paul A Scuffham, Robert S Ware, Nicolas H Hart, Robert U Newton
INTRODUCTION: Active surveillance is a strategy for managing low-risk, localised prostate cancer, where men are observed with serial prostate-specific antigen assessments to identify signs of disease progression. Currently, there are no strategies to support active surveillance compliance nor are there interventions that can prevent or slow disease progression, ultimately delaying transition to active treatment before it is clinically required. Recently, we proposed that exercise may have a therapeutic potential in delaying the need for active treatment in men on active surveillance...
April 20, 2018: BMJ Open
https://www.readbyqxmd.com/read/29678992/clinicians-and-researchers-perspectives-on-establishing-and-implementing-core-outcomes-in-haemodialysis-semistructured-interview-study
#19
Allison Tong, Sally Crowe, John S Gill, Tess Harris, Brenda R Hemmelgarn, Braden Manns, Roberto Pecoits-Filho, Peter Tugwell, Wim van Biesen, Angela Yee Moon Wang, David C Wheeler, Wolfgang C Winkelmayer, Talia Gutman, Angela Ju, Emma O'Lone, Benedicte Sautenet, Andrea Viecelli, Jonathan C Craig
OBJECTIVES: To describe the perspectives of clinicians and researchers on identifying, establishing and implementing core outcomes in haemodialysis and their expected impact. DESIGN: Face-to-face, semistructured interviews; thematic analysis. STETTING: Twenty-seven centres across nine countries. PARTICIPANTS: Fifty-eight nephrologists (42 (72%) who were also triallists). RESULTS: We identified six themes: reflecting direct patient relevance and impact (survival as the primary goal of dialysis, enabling well-being and functioning, severe consequences of comorbidities and complications, indicators of treatment success, universal relevance, stakeholder consensus); amenable and responsive to interventions (realistic and possible to intervene on, differentiating between treatments); reflective of economic burden on healthcare; feasibility of implementation (clarity and consistency in definition, easily measurable, requiring minimal resources, creating a cultural shift, aversion to intensifying bureaucracy, allowing justifiable exceptions); authoritative inducement and directive (endorsement for legitimacy, necessity of buy-in from dialysis providers, incentivising uptake); instituting patient-centredness (explicitly addressing patient-important outcomes, reciprocating trial participation, improving comparability of interventions for decision-making, driving quality improvement and compelling a focus on quality of life)...
April 20, 2018: BMJ Open
https://www.readbyqxmd.com/read/29678962/open-label-cluster-randomised-controlled-trial-and-economic-evaluation-of-a-brief-letter-from-a-gp-on-unscheduled-medical-contacts-associated-with-the-start-of-the-school-year-the-pleasant-trial
#20
Steven A Julious, Michelle J Horspool, Sarah Davis, Matthew Franklin, W Henry Smithson, Paul Norman, Rebecca M Simpson, Heather Elphick, Oscar Bortolami, Cindy Cooper
BACKGROUND: Asthma is seasonal with peaks in exacerbation rates in school-age children associated with the return to school following the summer vacation. A drop in prescription collection in August is associated with an increase in the number of unscheduled contacts after the school return. OBJECTIVE: To assess whether a public health intervention delivered in general practice reduced unscheduled medical contacts in children with asthma. DESIGN: Cluster randomised trial with trial-based economic evaluation...
April 20, 2018: BMJ Open
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