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https://www.readbyqxmd.com/read/29781832/gripping-and-anchoring-effects-on-the-mechanical-strengths-of-orthodontic-microimplants
#1
Chun-Ming Chen, Chun-Chan Ting, Huang-Chi Wang, Yu-Chuan Tseng
PURPOSE: The aim of this study was to evaluate the mechanical strengths in 5 different designs of orthodontic microimplants by analyzing their configuration of structure. MATERIALS AND METHODS: Thirty microimplants of 5 types (diameter 1.5 mm: type A, B, and C; diameter 1.3 mm: type D and E) were assessed. All microimplants were manually driven into the artificial bones at a 7-mm depth. The anchor area (AA), gripping area (GA), insertion torque (IT), Periotest value (PTV), and pullout strength (PS) were measured...
May 16, 2018: Implant Dentistry
https://www.readbyqxmd.com/read/29779627/in-vitro-assessment-of-ribose-modified-two-step-etch-and-rinse-dentine-adhesive
#2
U Daood, J K H Tsoi, P Neelakantan, J P Matinlinna, H A K Omar, M Al-Nabulsi, A S Fawzy
OBJECTIVE: Collagen fibrils aid in anchoring resin composite restorations to the dentine substrate. The aim of the study was to investigate effect of non-enzymatic glycation on bond strength and durability of demineralized dentine specimens in a modified two-step etch-and-rinse dentine adhesive. METHODS: Dentine surfaces were etched with 37% phosphoric acid, bonded with respective in vitro ethanol and acetone adhesives modified with (m/m, 0, 1%, 2% and 3% ribose), restored with restorative composite-resin, and sectioned into resin-dentine slabs and beams to be stored for 24h or 12 months in artificial saliva...
May 17, 2018: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/29777767/biglycan-is-a-new-high-affinity-ligand-for-cd14-in-macrophages
#3
Heiko Roedig, Madalina V Nastase, Helena Frey, Kristin Moreth, Jinyang Zeng-Brouwers, Chiara Poluzzi, Louise Tzung-Harn Hsieh, Christian Brandts, Simone Fulda, Malgorzata Wygrecka, Liliana Schaefer
Sterile inflammation is a therapeutic target in many diseases where it represents an important initiator of disease progression. However, the detailed mechanisms underlying its evolution and biological relevance are not yet completely elucidated. Biglycan, a prototype extracellular matrix-derived damage-associated molecular pattern, mediates sterile inflammation in macrophages through Toll-like receptor (TLR) 2 and/or TLR4-dependent signaling pathways. Here we discovered that soluble biglycan is a novel high-affinity ligand for CD14, a well-known GPI-anchored co-receptor for TLRs...
May 16, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/29776110/n-sma-smc-phase-transitions-probed-by-a-pair-of-elastically-bound-colloids
#4
Muhammed Rasi M, K P Zuhail, Arun Roy, Surajit Dhara
The competing effect of surface anchoring of dispersed microparticles and elasticity of nematic and cholesteric liquid crystals has been shown to stabilize a variety of topological defects. Here we study a pair of colloidal microparticles with homeotropic and planar surface anchoring across N-SmA-SmC phase transitions. We show that below the SmA-SmC phase transition the temperature dependence of interparticle separation (D) of colloids with homeotropic anchoring shows a power-law behavior; D∼(1-T/T_{AC})^{α}, with an exponent α≈0...
March 2018: Physical Review. E
https://www.readbyqxmd.com/read/29774653/matrix-glycoprotein-interactions-required-for-budding-of-a-plant-nucleorhabdovirus-and-induction-of-inner-nuclear-membrane-invagination
#5
Kai Sun, Xin Zhou, Wenye Lin, Xueping Zhou, Andrew O Jackson, Zhenghe Li
Nucleorhabdoviruses such as Sonchus yellow net virus (SYNV) replicate in the nuclei and undergo morphogenesis at the inner nuclear membrane (IM) in plant cells. Mature particles are presumed to form by budding of the Matrix (M) protein-nucleocapsid complexes through host IMs to acquire host phospholipids and the surface glycoproteins (G). To address mechanisms underlying nucleorhabdovirus budding, we generated recombinant SYNV G mutants containing a truncated amino-terminal (NT) or carboxyl-terminal (CT) domain...
May 18, 2018: Molecular Plant Pathology
https://www.readbyqxmd.com/read/29772011/induction-of-influenza-specific-local-cd8-t-cells-in-the-respiratory-tract-after-aerosol-delivery-of-vaccine-antigen-or-virus-in-the-babraham-inbred-pig
#6
Katie Tungatt, Garry Dolton, Sophie B Morgan, Meriem Attaf, Anna Fuller, Thomas Whalley, Johanneke D Hemmink, Emily Porter, Barbara Szomolay, Maria Montoya, John A Hammond, John J Miles, David K Cole, Alain Townsend, Mick Bailey, Pierre J Rizkallah, Bryan Charleston, Elma Tchilian, Andrew K Sewell
There is increasing evidence that induction of local immune responses is a key component of effective vaccines. For respiratory pathogens, for example tuberculosis and influenza, aerosol delivery is being actively explored as a method to administer vaccine antigens. Current animal models used to study respiratory pathogens suffer from anatomical disparity with humans. The pig is a natural and important host of influenza viruses and is physiologically more comparable to humans than other animal models in terms of size, respiratory tract biology and volume...
May 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29771116/a-sno2-reduced-graphene-oxide-interlayer-mitigating-shuttle-effect-of-li-s-batteries
#7
Nana Hu, Xingshuai Lv, Ying Dai, Linlin Fan, Dongbin Xiong, Xifei Li
The short cycle life of lithium-sulfur batteries (LSBs) plagues its practical application. In this study, a uniform SnO2/reduced graphene oxide (denoted as SnO2/rGO) composite is successfully designed onto the commercial polypropylene separator for use of interlayer of LSBs to decrease the charge transfer resistance and trap the soluble lithium polysulfides (LPS). As a result, the assembled devices using the separator modified with the functional interlayer (SnO2/rGO) exhibit improved cycle performance, for instance, over 200 cycles at 1C, the discharge capacity of the cells reaches 734 mAh g-1...
May 17, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29770985/cose2-mose2-heterostructures-with-enriched-water-adsorption-dissociation-sites-towards-enhanced-alkaline-hydrogen-evolution-reaction
#8
Guoqiang Zhao, Peng Li, Kun Rui, Yaping Chen, Shi Xue Dou, Wenping Sun
Transition metal dichalcogenides (TMDs) are promising electrocatalysts toward hydrogen evolution reaction (HER) in acid media, but they show significantly inferior activity in alkaline media due to the extremely sluggish water dissociation kinetics. Herein, CoSe2/MoSe2 heterostructures with CoSe2 quantum dots anchored on MoSe2 nanosheets are synthesized towards enhanced alkaline HER catalytic activity. The incorporation of CoSe2 is intended to construct additional water adsorption sites on the basal planes of MoSe2 to promote water dissociation...
May 17, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29770690/fluorinated-dna-micelles-synthesis-and-properties
#9
Jianmei Zou, Cheng Jin, Ruowen Wang, Hailan Kuai, Lili Zhang, Xiao-Bing Zhang, Juan Li, Liping Qui, Weihong Tan
Creating new functional building blocks that expand the versatility of nanostructures depends on bottom-up self-assembly of amphiphilic biomolecules. Inspired by the unique physicochemical properties of hydrophobic perfluorocarbons, coupled with the powerful functions of nucleic acids, we herein report the synthesis of a series of diperfluorodecyl-DNA conjugates (PF-DNA) which can efficiently self-assemble into micelles in aqueous solution. Based on the micelle structure, both target binding affinity and enzymatic resistance of the DNA probe can be enhanced...
May 17, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29770338/basic-fibroblast-growth-factor-fused-with-tandem-collagen-binding-domains-from-clostridium-histolyticum-collagenase-colg-increases-bone-formation
#10
Hiroyuki Sekiguchi, Kentaro Uchida, Osamu Matsushita, Gen Inoue, Nozomu Nishi, Ryo Masuda, Nana Hamamoto, Takaki Koide, Shintaro Shoji, Masashi Takaso
Basic fibroblast growth factor 2 (bFGF) accelerates bone formation during fracture healing. Because the efficacy of bFGF decreases rapidly following its diffusion from fracture sites, however, repeated dosing is required to ensure a sustained therapeutic effect. We previously developed a fusion protein comprising bFGF, a polycystic kidney disease domain (PKD; s2b), and collagen-binding domain (CBD; s3) sourced from the Clostridium histolyticum class II collagenase, ColH, and reported that the combination of this fusion protein with a collagen-like peptide, poly(Pro-Hyp-Gly)10 , induced mesenchymal cell proliferation and callus formation at fracture sites...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29769312/the-chloroplast-division-protein-arc6-acts-to-inhibit-disassembly-of-gdp-bound-ftsz2
#11
Min Woo Sung, Rahamthulla Shaik, Allan D TerBush, Katherine W Osteryoung, Stanislav Vitha, Andreas Holzenburg
Chloroplasts host photosynthesis and fulfill other metabolic functions that are essential to plant life. They have to divide by binary fission to maintain their numbers throughout cycles of cell division. Chloroplast division is achieved by a complex ring-shaped division machinery located on both the inner (stromal) and the outer (cytosolic) side of the chloroplast envelope. The inner division ring (termed the Z ring) is formed by the assembly of tubulin-like FtsZ1 and FtsZ2 proteins. ARC6 is a key chloroplast division protein that interacts with the Z ring...
May 16, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29768850/decoration-of-%C3%AE-fe%C3%A2-o%C3%A2-on-graphene-for-photocatalytic-and-supercapacitive-properties
#12
Yanping Miao, Ping Yang
The α-Fe2O3/graphene composites were obtained by solvothermal method, graphene oxide (GO) nanosheets were served as supporting materials for anchoring the α-Fe2O3, GO was reduced during this process. The morphology and structure of composites were characterized by X-ray powder diffraction, Scanning electron microscope and Transmission electron microscopy. Compared with the bare α-Fe2O3 nanoplates, the morphology of α-Fe2O3 decorated in graphene partly changed from nanoplates to truncate octahedral. Because of the synergistic effect of graphene and α-Fe2O3, the α-Fe2O3/graphene composites exhibited improved photocatalytic performance, significantly better than that of the bare α-Fe2O3 nanoplates...
January 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29768719/nio-nanoparticles-anchored-on-p-doped-%C3%AE-fe2o3-nanoarrays-an-efficient-hole-extraction-p-n-heterojunction-photoanode-for-water-oxidation
#13
Feng Li, Jing Li, Jie Zhang, Lili Gao, Xuefeng Long, Yiping Hu, Shuwen Li, Jun Jin, Jiantai Ma
The photoelectrochemical (PEC) water splitting efficiency of hematite-based photoanode is still far from the theoretical value due to its poor surface reaction kinetics and high density of surface trapping states. To solve these drawbacks, a photoanode consisting of NiO nanoparticles anchored on a gradient P-doped α-Fe2O3 nanorod (NR) array (NiO/P-α-Fe2O3) was fabricated to achieve optimal light absorption and charge separation, and rapid surface reaction kinetic. Specifically, the photoanode with the NR arrays structure allowed high mass transport rate to be achieved while the P-doping effectively decreased surface trapping sites and improved the electrical conductivity of α-Fe2O3...
May 16, 2018: ChemSusChem
https://www.readbyqxmd.com/read/29765680/the-relationship-between-substrate-morphology-and-biological-performances-of-nano-silver-loaded-dopamine-coatings-on-titanium-surfaces
#14
Weibo Zhang, Shuang Wang, Shaohua Ge, Jialong Chen, Ping Ji
Biomedical device-associated infection (BAI) and lack of osseointegration are the main causes of implant failure. Therefore, it is imperative for implants not only to depress microbial activity and biofilm colonization but also to prompt osteoblast functions and osseointegration. As part of the coating development for implants, the interest of in vitro studies on the interaction between implant substrate morphology and the coating's biological performances is growing. In this study, by harnessing the adhesion and reactivity of bioinspired polydopamine, nano-silver was successfully anchored onto micro/nanoporous as well as smooth titanium surfaces to analyse the effect of substrate morphology on biological performances of the coatings...
April 2018: Royal Society Open Science
https://www.readbyqxmd.com/read/29765659/self-assembly-behaviours-of-peptide-drug-conjugates-influence-of-multiple-factors-on-aggregate-morphology-and-potential-self-assembly-mechanism
#15
Qin Fan, Yujie Ji, Jingjing Wang, Li Wu, Weidong Li, Rui Chen, Zhipeng Chen
Peptide-drug conjugates (PDCs) as self-assembly prodrugs have the unique and specific features to build one-component nanomedicines. Supramolecular structure based on PDCs could form various morphologies ranging from nanotube, nanofibre, nanobelt to hydrogel. However, the assembly process of PDCs is too complex to predict or control. Herein, we investigated the effects of extrinsic factors on assembly morphology and the possible formation of nanostructures based on PDCs. To this end, we designed a PDC consisting of hydrophobic drug ( S )-ketoprofen (Ket) and valine-glutamic acid dimeric repeats peptide (L-VEVE) to study their assembly behaviour...
April 2018: Royal Society Open Science
https://www.readbyqxmd.com/read/29762008/binary-hierarchical-porous-graphene-pyrolytic-carbon-nanocomposite-matrix-loaded-with-sulfur-as-high-performance-li-s-battery-cathode
#16
Hang Zhang, Qiuming Gao, Weiwei Qian, Hong Xiao, Zeyu Li, Li Ma, Xuehui Tian
N, O-codoped hierarchical porous nanocomposite consisted of binary reduced graphene oxide and pyrolytic carbon from chitosan (rGO/PC) is fabricated. The optimized rGO/PC possesses micropores with size distribution concentrated around 1.1 nm and plenty of meso/macropores. The BET specific surface area is 480.8 m2 g-1, and impressively large pore volume of 2.14 cm3 g-1. Based on the synergistic effects of the following main factors: (i) the confined space effect in the hierarchical porous binary carbonaceous matrix, (ii) the anchor effects by strong chemical bonds with codoped N and O atoms; and (iii) the good flexibility and conductivity of rGO, the rGO/PC/S holding 75 wt...
May 15, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29760450/caveolin-3-differentially-orchestrates-cholinergic-and-serotonergic-constriction-of-murine-airways
#17
M Keshavarz, M Skill, M I Hollenhorst, S Maxeiner, M Walecki, U Pfeil, W Kummer, G Krasteva-Christ
The mechanisms of controlling airway smooth muscle (ASM) tone are of utmost clinical importance as inappropriate constriction is a hallmark in asthma and chronic obstructive pulmonary disease. Receptors for acetylcholine and serotonin, two relevant mediators in this context, appear to be incorporated in specialized, cholesterol-rich domains of the plasma membrane, termed caveolae due to their invaginated shape. The structural protein caveolin-1 partly accounts for anchoring of these receptors. We here determined the role of the other major caveolar protein, caveolin-3 (cav-3), in orchestrating cholinergic and serotonergic ASM responses, utilizing newly generated cav-3 deficient mice...
May 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29756758/a-highly-active-and-durable-core-shell-fct-pdfe-pd-nanoparticles-encapsulated-ng-as-an-efficient-catalyst-for-oxygen-reduction-reaction
#18
Kakali Maiti, Jayaraman Balamurugan, Shaik Gouse Peera, Prof Nam Hoon Kim, Joong-Hee Lee
Development of highly active and durable catalysts for oxygen reduction reaction (ORR) alternative to Pt-based catalyst is an essential topic of interest in research community but challenging task. Here, we have developed a new type of face-centered tetragonal (fct) PdFe alloy nanoparticles encapsulated Pd (fct-PdFe@Pd) anchored onto nitrogen-doped graphene (NG). This core-shell fct-PdFe@Pd@NG hybrid is fabricated by facile and cost-effective technique. The effect of temperature on the transformation of face-centered cubic (fcc) to fct structure and their effect on ORR activity are systematically investigated...
May 14, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29753013/transferrin-anchored-poly-lactide-micelles-to-improve-anticancer-activity-of-curcumin-in-hepatic-and-cervical-cancer-cell-monolayers-and-3d-spheroids
#19
Preeti Kumari, Sri Vishnu Kiran Rompicharla, Omkara Swami Muddineti, Balaram Ghosh, Swati Biswas
In recent years, actively targeted drug delivery systems have been utilized in pre-clinical studies for site-specific delivery of drugs, which reduces toxicities associated with chemotherapy. This study reports the preparation of the tumor homing ligand, transferrin (Tf) anchored methoxy-polyethylene glycol-poly(d,l-lactide) polymeric micelles (Tf-PP). Curcumin which possess wide anti-cancer activity was loaded into the micelles. Tf-PPC with average particle size of 132.16 ± 1.3 nm and encapsulation efficiency of 88...
May 9, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29752501/it-is-safe-and-effective-to-use-all-inside-meniscal-repair-devices-for-posteromedial-meniscal-ramp-lesions
#20
Giles Heilpern, Jo Stephen, Simon Ball, Andrew Amis, Andy Williams
PURPOSE: Recently, it has been recognized that meniscocapsular ('ramp') lesions of the posterior one-third of the medial meniscus frequently occur during injuries causing ACL rupture, and that these lesions are easily missed at arthroscopy. Furthermore, it is clear that these lesions are biomechanically significant, adding to the deficits caused by ACL rupture, and that their repair can reverse this. The efficacy of an all inside repair technique has been questioned by some authors and by those who advocate a suture shuttle technique via an accessory posteromedial portal...
May 12, 2018: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
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