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https://www.readbyqxmd.com/read/28727999/drug-ion-co-delivery-multi-functional-nanocarrier-to-regenerate-infected-tissue-defect
#1
Jung-Hwan Lee, Ahmed El-Fiqi, Nandin Mandakhbayar, Hae-Hyoung Lee, Hae-Won Kim
Regeneration of infected tissues is a globally challenging issue in medicine and dentistry. Common clinical therapies involving a complete removal of infected areas together with a treatment of antimicrobial drugs are often suboptimal. Biomaterials with anti-bacterial and pro-regenerative potential can offer a solution to this. Here we design a novel nanocarrier based on a mesoporous silicate-calcium glass by doping with Ag ions and simultaneously loading antimicrobial drugs onto mesopores. The nanocarriers could controllably release multiple ions (silver, calcium, and silicate) and drugs (tetracycline or chlorohexidine) to levels therapeutically relevant, and effectively internalize to human dental stem cells (∼90%) with excellent viability, ultimately stimulating odontogenic differentiation...
July 12, 2017: Biomaterials
https://www.readbyqxmd.com/read/28727450/carbon-nanotube-reinforced-polymer-stabilized-liquid-crystal-device-lowered-and-thermally-invariant-threshold-with-accelerated-dynamics
#2
Subbarao Krishna Prasad, Marlin Baral, Adhigan Murali, Sellamuthu N Jaisankar
Polymer stabilized liquid crystal (PSLC) devices comprise a polymer matrix in an otherwise continuous phase of liquid crystal. The fibrils of the polymer provide, even in the bulk, virtual surfaces with finite anchoring energy resulting in attractive electro-optic properties. Here we describe a novel variation of the PSLC device fabricated by reinforcing the polymer matrix with polymer-capped single-walled carbon nanotubes (CNTs). The most important outcome of this strengthening of the polymer strands is that the threshold voltage associated with the electro-optic switching becomes essentially temperature independent in marked contrast to the significant thermal variation seen in the absence of the nanotubes...
July 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28726147/stent-migration-following-endoscopic-suture-fixation-of-esophageal-self-expandable-metal-stents-a-systematic-review-and-meta-analysis
#3
Ryan Law, Anoop Prabhu, Larissa Fujii-Lau, Carol Shannon, Siddharth Singh
BACKGROUND: Covered self-expandable metal stents (SEMS) are utilized for the management of benign and malignant esophageal conditions; however, covered SEMS are prone to migration. Endoscopic suture fixation may mitigate the migration risk of covered esophageal SEMS. Hence, we conducted a systematic review and meta-analysis to evaluate the effectiveness and safety of endoscopic suture fixation for covered esophageal SEMS. METHODS: Following PRISMA guidelines, we performed a systematic review from 2011 to 2016 to identify studies (case control/case series) reporting the technical success and migration rate of covered esophageal SEMS following endoscopic suture fixation...
July 19, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28724265/facile-synthesis-of-sio2-c-nanoparticles-anchored-on-mwnt-as-high-performance-anode-materials-for-li-ion-batteries
#4
Yan Zhao, Zhengjun Liu, Yongguang Zhang, Almagul Mentbayeva, Xin Wang, M Yu Maximov, Baoxi Liu, Zhumabay Bakenov, Fuxing Yin
Carbon-coated silica nanoparticles anchored on multi-walled carbon nanotubes (SiO2@C/MWNT composite) were synthesized via a simple and facile sol-gel method followed by heat treatment. Scanning and transmission electron microscopy (SEM and TEM) studies confirmed densely anchoring the carbon-coated SiO2 nanoparticles onto a flexible MWNT conductive network, which facilitated fast electron and lithium-ion transport and improved structural stability of the composite. As prepared, ternary composite anode showed superior cyclability and rate capability compared to a carbon-coated silica counterpart without MWNT (SiO2@C)...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28723170/highly-efficient-multiple-anchored-fluorescent-probe-for-the-detection-of-aniline-vapor-based-on-synergistic-effect-chemical-reaction-and-pet
#5
Zinuo Jiao, Yu Zhang, Wei Xu, Xiangtao Zhang, Haibo Jiang, Pengcheng Wu, Yanyan Fu, Qingguo He, Huimin Cao, Jiangong Cheng
A multiple-anchored fluorescent probe ((((hexane-1,6-diylbis(2,7-bis(4-formyl)-phenyl)-9H-fluorine-9,9-diyl))-bis(hexane-6,1-diyl))-bis(9H-carbazole-9,3,6-triyl))-tetrakis(benzene-4,1-diyl))-tetraformyl-(8FP-2F) with eight aldehyde groups was designed and synthesized. The molecule has four branches and highly twisted structure. Furthermore, it tends to self-assemble into nanospheres, which is beneficial for gaseous analyte penetration and high fluorescence quantum efficiency. Among gaseous analytes, detection of aniline vapor is extraordinarily important in the control of environmental issues and human diseases...
May 26, 2017: ACS Sensors
https://www.readbyqxmd.com/read/28723066/antimony-anchored-with-nitrogen-doping-porous-carbon-as-high-performance-anode-materials-for-na-ion-batteries
#6
Tianjing Wu, Hongshuai Hou, Chenyang Zhang, Peng Ge, Zhaodong Huang, Mingjun Jing, Xiaoqing Qiu, Xiaobo Ji
Antimony represents a class of unique functional materials in sodium-ion batteries with high theoretical capacity (660 mAh g-1). The utilization of carbonaceous materials as buffer layer has been considered as an effective approach to alleviate rapid capacity fading. Herein, the antimony/nitrogen-doping porous carbon (Sb/NPC) composite with polyaniline nanosheets as carbon source has been successfully achieved. And, our strategy involves three processes-tunable organic polyreaction, thermal annealing process and cost-effective reduction reaction...
July 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28722550/the-hub-and-spoke-organization-design-an-avenue-for-serving-patients-well
#7
James K Elrod, John L Fortenberry
BACKGROUND: The healthcare industry is characterized by intensive, never-ending change occurring on a multitude of fronts. Success in such tumultuous environments requires healthcare providers to be proficient in myriad areas, including the manner in which they organize and deliver services. Less efficient designs drain precious resources and hamper efforts to deliver the best care possible to patients, making it imperative that optimal pathways are identified and pursued. One particular avenue that offers great potential for serving patients efficiently and effectively is known as the hub-and-spoke organization design...
July 11, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28721844/cd81-large-extracellular-loop-containing-fusion-proteins-with-a-dominant-negative-effect-on-hcv-cell-spread-and-replication
#8
Boyan Grigorov, Jennifer Molle, Eric Rubinstein, Fabien Zoulim, Birke Bartosch
The roles of CD81 in the hepatitis C virus (HCV) life cycle are multiple but remain ill characterized. CD81 is known to interact with the HCV glycoproteins as an attachment factor. It also has an important role in the post-attachment entry process. Its interaction with claudin-1, for example, is vital for viral uptake and trafficking. Furthermore, CD81 and its role in membrane organization and trafficking are thought to play a pivotal role in HCV replication. Some of these functions are particularly limited to human CD81; others can be substituted with CD81 molecules from other species...
July 18, 2017: Journal of General Virology
https://www.readbyqxmd.com/read/28720740/-tentorial-dural-arteriovenous-fistula-successfully-treated-with-transvenous-embolization-using-a-double-catheterization-technique-through-venous-drainage-a-case-report
#9
Akira Yamakawa, Atsushi Fujita, Hirotomo Tanaka, Mitsuru Ikeda, Masashi Morikawa, Eiji Kohmura
BACKGROUND: Tentorial dural arteriovenous fistulas(dAVFs)are a rare clinical entity accounting for less than 10% of all intracranial dAVFs. Because these lesions are characterized by high hemorrhagic risk, aggressive treatment should be considered. Although the number of reported cases treated with endovascular transarterial embolization(TAE)using glue has been increasing, little is known about the transvenous approach. Here, we report the case of a patient with a tentorial dAVF who was successfully treated with transvenous embolization(TVE)through venous drainage using a double catheterization technique...
July 2017: No Shinkei Geka. Neurological Surgery
https://www.readbyqxmd.com/read/28719876/photoelectrocatalytic-degradation-of-methylene-blue-using-f-doped-tio2-photoelectrode-under-visible-light-irradiation
#10
Dong Liu, Renwen Tian, Jianqiao Wang, Er Nie, Xianqing Piao, Xin Li, Zhuo Sun
Photoelectrocatalysis (PEC) has attracted great interest due to cost effectiveness and high efficiency in water treatment. In this study, F doped TiO2 (F-TiO2) photoelectrodes with honeycomb like morphology were prepared, and the PEC performance was investigated. F-TiO2 particles that showed enhanced absorption of visible light were synthesized via a sol-gel method. F-TiO2 particles were anchored onto the surface of F-doped SnO2 glass by a screen-printing method to prepare the F-TiO2 photoelectrodes. The PEC performance of the F-TiO2 photoelectrodes was investigated via the degradation of methylene blue (MB) under visible light irradiation...
July 14, 2017: Chemosphere
https://www.readbyqxmd.com/read/28719860/liposome-modified-titanium-surface-a-strategy-to-locally-deliver-bioactive-molecules
#11
Vincenzo De Leo, Monica Mattioli-Belmonte, Maria Teresa Cimmarusti, Annamaria Panniello, Manuela Dicarlo, Francesco Milano, Angela Agostiano, Elvira De Giglio, Lucia Catucci
Titanium and its alloys are widely employed materials for implants in orthopedic or dental surgery due to their mechanical properties, resistance to corrosion and osseointegration capability. However adverse reactions at the tissue/implant interface may occur, which limit the success of the osseointegration process. Therefore, different strategies have to be used to overcome these drawbacks. In this work, we developed two different liposome-based coatings on titanium surfaces as drug or bioactive molecule deposits for dental/orthopedic implant applications...
July 8, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28719716/the-sophono-bone-conduction-system-surgical-audiologic-and-quality-of-life-outcomes
#12
Timothy Mclean, Irumee Pai, Andrew Philipatos, Michael Gordon
We prospectively evaluated the surgical, audiologic, and quality-of-life outcomes in 5 patients-2 men and 3 women, aged 22 to 64 years (mean: 41.8)-who were implanted with the Sophono Alpha 2 MPO Processor. The indications for implantation of this bone-conduction device included recurrent ear canal infections with hearing aids (n = 3), single-sided deafness (n = 1), and patient preference in view of difficulty using a conventional hearing aid (n = 1). In addition to the patient with single-sided deafness, 3 patients had a bilateral mixed hearing loss and 1 had a bilateral conductive hearing loss...
July 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/28718807/melanin-and-melanin-related-polymers-as-materials-with-biomedical-and-biotechnological-applications-cuttlefish-ink-and-mussel-foot-proteins-as-inspired-biomolecules
#13
REVIEW
Francisco Solano
The huge development of bioengineering during the last years has boosted the search for new bioinspired materials, with tunable chemical, mechanical, and optoelectronic properties for the design of semiconductors, batteries, biosensors, imaging and therapy probes, adhesive hydrogels, tissue restoration, photoprotectors, etc. These new materials should complement or replace metallic or organic polymers that cause cytotoxicity and some adverse health effects. One of the most interesting biomaterials is melanin and synthetic melanin-related molecules...
July 18, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28716750/hexadecylphosphocholine-miltefosine-stabilized-chitosan-modified-ampholipospheres-as-prototype-co-delivery-vehicle-for-enhanced-killing-of-l-donovani
#14
Priyanka Tripathi, Anil Kumar Jaiswal, Anuradha Dube, Prabhat Ranjan Mishra
Lipid nanoparticles are stable, biodegradable and biocompatible carriers offering excellent therapeutic efficacy. Here, a novel effort has been made to develop Miltefosine (HePC- hexadecylphosphocholine) stabilized chitosan anchored nanostructured lipid carriers (NLC) of Amphotericin B (AmB) as co-delivery vehicle to enhance killing of L. donovani. The entrapment efficiency of AmB was achieved upto 85.3% for HePC-AmB-CNLCs with mean particle size of 150.8±8.4nm, and zeta potential value of +28.2±1.1mV, respectively...
July 14, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28716681/mri-magic-angle-effect-in-femorotibial-cartilages-of-the-red-kangaroo
#15
Tonima S Ali, Namal Thibbotuwawa, YuanTong Gu, Konstantin I Momot
OBJECTIVE: Kangaroo knee cartilages are robust tissues that can support knee flexion and endure high levels of compressive stress. This study aimed to develop a detailed understanding of the collagen architecture in kangaroo knee cartilages and thus obtain insights into the biophysical basis of their function. DESIGN: Cylindrical/square plugs from femoral and tibial hyaline cartilage and tibial fibrocartilage were excised from the knees of three adult red kangaroos...
July 14, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28707817/evaluation-of-free-or-anchored-antimicrobial-peptides-as-candidates-for-the-prevention-of-orthopaedic-device-related-infections
#16
Francesca D'Este, Debora Oro, Gerard Boix-Lemonche, Alessandro Tossi, Barbara Skerlavaj
The prevention of implant-associated infection, one the most feared complications in orthopaedic surgery, remains a major clinical challenge and urges development of effective methods to prevent bacterial colonization of implanted devices. Alpha-helical antimicrobial peptides (AMPs) may be promising candidates in this respect due to their potent and broad-spectrum antimicrobial activity, their low tendency to elicit resistance and possible retention of efficacy in the immobilized state. The aim of this study was to evaluate the potential of five different helical AMPs, the cathelicidins BMAP-27 and BMAP-28, their (1-18) fragments and the rationally designed, artificial P19(9/G7) peptide, for the prevention of orthopaedic implant infections...
July 14, 2017: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://www.readbyqxmd.com/read/28707072/catechol-o-methyltransferase-val158met-polymorphism-on-striatum-structural-covariance-networks-in-alzheimer-s-disease
#17
Chiung-Chih Chang, Shih-Jen Tsai, Nai-Ching Chen, Chi-Wei Huang, Shih-Wei Hsu, Ya-Ting Chang, Mu-En Liu, Wen-Neng Chang, Wan-Chen Tsai, Chen-Chang Lee
The catechol-O-methyltransferase enzyme metabolizes dopamine in the prefrontal axis, and its genetic polymorphism (rs4680; Val158Met) is a known determinant of dopamine signaling. In this study, we investigated the possible structural covariance networks that may be modulated by this functional polymorphism in patients with Alzheimer's disease. Structural covariance networks were constructed by 3D T1 magnetic resonance imaging. The patients were divided into two groups: Met-carriers (n = 91) and Val-homozygotes (n = 101)...
July 13, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28706818/arthroscopic-repair-of-posterior-bony-bankart-lesion-and-subscapularis-remplissage
#18
Colten Luedke, Stefan J Tolan, John M Tokish
Posterior shoulder instability with glenoid bone loss has only a fraction of the prevalence of anterior instability. Unlike the latter, there is a paucity of literature regarding the treatment of posterior bony Bankart lesions and even less with concomitant reverse Hill-Sachs lesions. This combination of pathology leads to a difficult situation regarding treatment options. We present our technique for arthroscopic repair of a posterior bony Bankart lesion and reverse Hill-Sachs lesion. The importance of proper portal placement cannot be overstated...
June 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/28705206/digital-evaluation-of-nasal-changes-induced-by-rapid-maxillary-expansion-with-different-anchorage-and-appliance-design
#19
Rosamaria Fastuca, Paola Lorusso, Manuel O Lagravère, Ambra Michelotti, Marco Portelli, Piero Antonio Zecca, Vincenzo D' Antò, Angela Militi, Riccardo Nucera, Alberto Caprioglio
BACKGROUND: Scientific evidence showed that rapid maxillary expansion (RME) affects naso-maxillary complex, increasing nasal width and volume. This study aimed to evaluate nasal changes induced by rapid maxillary expansion with different anchorage and appliance design by using low dose and cone beam computed tomography. METHODS: A total of 44 patients (20 males, mean age 8y 8 m ± 1y 2 m; 24 females mean age 8y 2 m ± 1y 4 m) were included in the investigation and divided into three groups according to the appliance: Hyrax-type expander anchored to permanent teeth, modified Hyrax-type expander anchored to deciduous teeth, modified Haas-type expander anchored to deciduous teeth...
July 14, 2017: BMC Oral Health
https://www.readbyqxmd.com/read/28704926/a-label-free-and-ultrasensitive-immunosensor-for-detection-of-human-chorionic-gonadotrophin-based-on-graphene-fets
#20
Kamrul Islam, Ahmed Suhail, Genhua Pan
We report on a label-free immunosensor based on graphene field effect transistors (G-FETs) for the ultrasensitive detection of Human Chorionic Gonadotrophin (hCG), as an indicator of pregnancy and related disorders, such as actopic pregnancy, choriocarcinoma and orchic teratoma. Pyrene based bioactive ester was non-covalently anchored onto the graphene channel in order to retain the sp² lattice. The G-FET transfer characteristics showed repeatable and reliable responses in all surface modifying steps using a direct current (DC) readout system...
July 12, 2017: Biosensors
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