Cristina Concetti, Paulius Viskaitis, Nikola Grujic, Sian N Duss, Mattia Privitera, Johannes Bohacek, Daria Peleg-Raibstein, Denis Burdakov
Information seeking, such as standing on tiptoes to look around in humans, is observed across animals and helps survival. Its rodent analog - unsupported rearing on hind legs - was a classic model in deciphering neural signals of cognition, and is of intense renewed interest in preclinical modeling of neuropsychiatric states. Neural signals and circuits controlling this dedicated decision to seek information remain largely unknown. While studying sub-second timing of spontaneous behavioral acts and activity of MCH neurons (MNs) in behaving male and female mice, we observed large MN activity spikes that aligned to unsupported rears...
April 4, 2024: Journal of Neuroscience