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https://www.readbyqxmd.com/read/29452350/extra-virgin-olive-oil-contains-a-metabolo-epigenetic-inhibitor-of-cancer-stem-cells
#1
Bruna Corominas-Faja, Elisabet Cuyàs, Jesús Lozano-Sánchez, Sílvia Cufí, Sara Verdura, Salvador Fernández-Arroyo, Isabel Borrás-Linares, Begoña Martin-Castillo, Ángel G Martin, Ruth Lupu, Alfons Nonell-Canals, Melchor Sanchez-Martinez, Vicente Micol, Jorge Joven, Antonio Segura-Carretero, Javier A Menendez
Targeting tumor-initiating, drug-resistant populations of cancer stem cells (CSC) with phytochemicals is a novel paradigm for cancer prevention and treatment. We herein employed a phenotypic drug discovery approach coupled to mechanism-of-action profiling and target deconvolution to identify phenolic components of extra virgin olive oil (EVOO) capable of suppressing the functional traits of CSC in breast cancer (BC). In vitro screening revealed that the secoiridoid decarboxymethyl oleuropein aglycone (DOA) could selectively target sub-populations of epithelial-like, aldehyde dehydrogenase (ALDH)-positive and mesenchymal-like, CD44+CD24-/low CSC...
February 14, 2018: Carcinogenesis
https://www.readbyqxmd.com/read/29450654/visualizing-protoporphyrin-ix-formation-in-the-dura-tail-of-meningiomas-by-mass-spectrometry-imaging
#2
Benjamin Brokinkel, Sabrina Kröger, Volker Senner, Astrid Jeibmann, Uwe Karst, Walter Stummer
BACKGROUND: The advantages of 5-aminolevulinacid (5-ALA)-induced fluorescence-guided surgery in meningiomas are increasingly discussed. In this context, despite detectable tumor tissue in histopathologial analyses, no fluorescence was shown at the dura tail using the standard operating microscope. Thus, 5-ALA metabolism in this surgically important site remains unknown but needs to be elucidated when further evaluating indications of fluorescence-guided surgery in meningiomas. METHOD: We here present the spatially resolved identification of protoporphyrin IX (PpIX) in sphenoid ridge meningioma cryosections from a patient who underwent fluorescence-guided microsurgery using molecular imaging analysis by matrix-assisted laser desorption/ionization tandem mass spectrometry (MALDI-MS/MS)...
February 15, 2018: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29448307/histopathological-changes-resulting-from-selective-internal-radiotherapy-sirt
#3
Christoph Justinger, Juliana Gruden, Konstantinos Kouladouros, Christos Stravodimos, Peter Reimer, Andrea Tannapfel, Martin Binnenhei, Martin Bentz, Klaus Tatsch, Thomas Rüdiger, Michael R Schön
BACKGROUND: Selective internal radiotherapy (SIRT) has emerged as an effective therapy for patients with liver malignancies. Here, we report our analysis of histopathological changes in tumors and healthy liver tissue after SIRT and liver resection. Our main intent was to determine if specific histopathological changes occur in tumor and normal liver tissues. METHODS: We identified 17 patients in whom SIRT was applied to achieve liver resectability. Samples were taken from the resected liver tissue...
February 15, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29435940/mechanism-and-method-for-generating-tumor-free-ips-cells-using-intronic-microrna-mir-302-induction
#4
Shi-Lung Lin, Shao-Yao Ying
Today's researchers generating induced pluripotent stem cells (iPS cells or iPSCs) usually consider their pluripotency rather than potential tumorigenicity. Oncogenic factors such as c-Myc and Klf4 are frequently used to boost the survival and proliferative rates of iPSCs, creating an inevitable problem of tumorigenicity that hinders the therapeutic usefulness of these iPSCs. To prevent stem cell tumorigenicity, we have examined mechanisms by which the cell cycle genes are regulated in embryonic stem cells (ESCs)...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29429400/histologic-processing-artifacts-and-inter-pathologist-variation-in-measurement-of-inked-margins-of-canine-mast-cell-tumors
#5
Patti K Kiser, Christiane V Löhr, Danielle Meritet, Sean T Spagnoli, Milan Milovancev, Duncan S Russell
Although quantitative assessment of margins is recommended for describing excision of cutaneous malignancies, there is poor understanding of limitations associated with this technique. We described and quantified histologic artifacts in inked margins and determined the association between artifacts and variance in histologic tumor-free margin (HTFM) measurements based on a novel grading scheme applied to 50 sections of normal canine skin and 56 radial margins taken from 15 different canine mast cell tumors (MCTs)...
February 1, 2018: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/29424576/immunohistochemical-and-electron-microscopic-morphometric-image-analysis-of-hepatocellular-carcinoma-in-association-of-hcv-infection
#6
Sarah Hassan, Soheir S Mansy, Sahar A Tabak, Ahmed S AbdelFattah, Ahmed M Abdel-Aziz, Olfat Hamam, Mohammed I Seleem, Amr Abdelaal
Early detection of hepatocellular carcinoma (HCC) is crucial for successful therapy. The present work examined the value of ultrastructural morphometric image analysis of hepatocyte nuclei in patients with chronic hepatitis C virus (HCV) versus HCC cases with chronic HCV and the corresponding surgical tumor-free safe margins (TFMs), to highlight any early predictive signs of neoplastic cellular transformation. This work also performed an immunohistochemical assessment of cytokeratin 19 (CK19) and Ki-67-positive cells to visualize any associated proliferative activity in the examined groups...
February 9, 2018: Ultrastructural Pathology
https://www.readbyqxmd.com/read/29423784/ocular-surface-squamous-neoplasia-in-a-setting-of-fungal-keratitis-a-rare-co-occurrence
#7
Swati Singh, Ruchi Mittal, Purvasha Narang, Vikas Mittal
PURPOSE: To describe a rare co-occurrence of ocular surface squamous neoplasia (OSSN) in a patient with microbial keratitis. METHODS: Case report. RESULTS: We describe a 68-years female who developed ocular surface squamous neoplasia (OSSN) in an eye with culture proven severe fungal keratitis of 5 months duration, which progressed to endophthalmitis. She was managed with extended enucleation for left eye. Histopathology examination was consistent with squamous cell carcinoma of ocular surface with no corneal stromal/scleral/anterior chamber involvement...
February 8, 2018: International Ophthalmology
https://www.readbyqxmd.com/read/29394660/-neoadjuvant-chemoradiotherapy-for-locally-advanced-carcinoma-associated-with-anal-fistula
#8
Teppei Miyakawa, Satoru Iida, Takahiro Igaki, Hiroyuki Shiobara, Ryo Matsumoto, Katsutaka Mitachi, Yoshiteru Ohata, Katsumasa Saito, Tomoya Miura, Takumi Irie, Shigeru Yamazaki
The patient was a 59-year-old man. He was admitted to our hospital because of increasing anal pain with induration of the perianal region. There were large secondary orifices with mucous discharge on the left side of the perineal resion and buttock. We diagnosed adenocarcinoma on analysis of a biopsy specimen from induration of the perianal region. Pelvic CT and MRI showed that the tumor spreaded within the pelvis, with invasion of the prostate and sacrum. We performed neoadjuvant chemoradiotherapy preoperatively...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29390405/comparison-of-outcomes-of-surgeon-performed-intraoperative-ultrasonography-guided-wire-localization-and-preoperative-wire-localization-in-nonpalpable-breast-cancer-patients-undergoing-breast-conserving-surgery-a-retrospective-cohort-study
#9
Young Duck Shin, Young Jin Choi, Dae Hoon Kim, Sung Su Park, Hanlim Choi, Dong Ju Kim, Sungmin Park, Hyo Yung Yun, Young Jin Song
This study aimed to determine the efficacy of intraoperative ultrasonography-guided wire localization guided breast-conserving surgery (BCS) for nonpalpable breast cancer and compare it to conventional preoperative wire localization (PWL) guided surgery.We retrospectively analyzed the medical charts of 214 consecutive nonpalpable breast cancer patients who underwent BCS using intraoperative ultrasonography-guided wire localization by a surgeon (IUWLS) and PWL, between April 2013 and March 2017. Positive surgical margins, reexcision rates, and resection volumes were investigated...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29387181/application-of-novel-targeting-nanoparticles-contrast-agent-combined-with-contrast-enhanced-computed-tomography-during-screening-for-early-phase-gastric-carcinoma
#10
Kaimin Zhang, Xijian Du, Kaihu Yu, Kaiyu Zhang, Yicheng Zhou
Gastric cancer is one of the most common human tumors worldwide. The biggest bottleneck is a lack of advanced and sensitive protocols for the diagnosis of patients with early-stage gastric cancer. Therefore, more sensitive methods of diagnosing gastric cancer are urgently required to improve survival rates. In this clinical study, contrast-enhanced computed tomography (CECT) with targeting nanoparticles contrast agent (CECT-TNCA) was used to diagnose early-stage gastric cancer. The specific-targeted tyrosine kinase inhibitors of gastric cancer, including platelet-derived growth factor receptor-β, Ret and Kit, were used as TNCAs...
January 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29383121/targeting-the-sumo-pathway-as-a-novel-treatment-for-anaplastic-thyroid-cancer
#11
James P De Andrade, Allison W Lorenzen, Vincent T Wu, Maria V Bogachek, Jung M Park, Vivian W Gu, Claire M Sevenich, Victoria C Cassady, Anna C Beck, Mikhail V Kulak, Robert A Robinson, Geeta Lal, Ronald J Weigel
Cancer stem cells (CSCs) are expanded in anaplastic thyroid cancer (ATC) and standard treatment approaches have failed to improve survival, suggesting a need to specifically target the CSC population. Recent studies in breast and colorectal cancer demonstrated that inhibition of the SUMO pathway repressed CD44 and cleared the CSC population, mediated through SUMO-unconjugated TFAP2A. We sought to evaluate effects of inhibiting the SUMO pathway in ATC. ATC cell lines and primary ATC tumor samples were evaluated...
December 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29372248/prevalence-of-high-risk-human-papillomavirus-in-tonsil-tissue-in-healthy-adults-and-colocalization-in-biofilm-of-tonsillar-crypts
#12
Katherine K S Rieth, Steven R Gill, Abberly A Lott-Limbach, Mark A Merkley, Nathalia Botero, Paul D Allen, Matthew C Miller
Importance: The pathogenesis of human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma is currently an important topic of elucidation. The presence of latent HPV infection in tonsil tissue of healthy adults may provide an explanation for a component of this process and contribute to the understanding of HPV-associated squamous cell carcinoma oncogenesis of the oropharynx. Objective: To determine the prevalence of oropharyngeal HPV and to determine the spatial relationship between the virus and crypt biofilm in tonsil tissue...
January 25, 2018: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29368209/breast-cancer-risk-associated-with-genes-encoding-dna-repair-mrn-complex-a-study-from-punjab-pakistan
#13
Rabbia Tariq Khan, Ayesha Siddique, Naeem Shahid, Samina Khokher, Warda Fatima
BACKGROUND: Variants of DNA repair genes are extensively reported to cause genetic instability and increase the risk of breast cancer. In combination with NBS1, MRE11 and RAD50 constitute an MRN (MRE11-RAD50-NBS1) complex that repairs DNA damage. However, certain genetic alterations in MRE11 and RAD50 produce abnormal protein that affects the repairing process and may result in malignancy. We aimed to investigate the association of MRE11 and RAD50 polymorphisms with breast risk in the female population of Punjab, Pakistan...
January 24, 2018: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/29363134/the-net-acid-extruders-nhe1-nbcn1-and-mct4-promote-mammary-tumor-growth-through-distinct-but-overlapping-mechanisms
#14
Anne Poder Andersen, Jacob Samsøe-Petersen, Eva Kjer Oernbo, Ebbe Boedtkjer, José M A Moreira, Marie Kveiborg, Stine Falsig Pedersen
High metabolic and proliferative rates in cancer cells lead to production of large amounts of H+ and CO2 , and as a result, net acid extruding transporters are essential for the function and survival of cancer cells. We assessed protein expression of the Na+ /H+ exchanger NHE1, the Na+ -HCO3- cotransporter NBCn1, and the lactate-H+ cotransporters MCT1 and -4 by immunohistochemical analysis of a large cohort of breast cancer samples. We found robust expression of these transporters in 20, 10, 4 and 11 percent of samples, respectively...
January 24, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29355051/fraction-from-lycium-barbarum-polysaccharides-reduces-immunotoxicity-and-enhances-antitumor-activity-of-doxorubicin-in-mice
#15
Xiangliang Deng, Shuang Luo, Xia Luo, Minghua Hu, Fangli Ma, Yuanyuan Wang, Lian Zhou, Rongrong Huang
The aim of the present study was to investigate whether fraction from Lycium barbarum polysaccharide (LBP) could reduce immunotoxicity and enhance antitumor activity of doxorubicin (Dox) in mice. A water-soluble LBP fraction, designated LBP3, was isolated from edible Chinese herbal Lycium barbarum and used in this study. To investigate the effect of LBP3 on Dox-induced immunotoxicity, tumor-free mice were used and treated with either normal saline, Dox, or Dox plus LBP3. To investigate the effect of LBP3 on antitumor activity of Dox, H22 tumor-bearing mice were used and treated with either normal saline, Dox, LBP3, or Dox plus LBP3...
January 1, 2018: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/29353230/a-model-of-dormant-emergent-metastatic-breast-cancer-progression-enabling-exploration-of-biomarker-signatures
#16
Amanda M Clark, Manu Kumar, Sarah Wheeler, Carissa Young, Raman Venkataramanan, Donna Stolz, Linda Griffith, Douglas A Lauffenburger, Alan Wells
Breast cancer mortality predominantly results from dormant micrometastases that emerge as fatal outgrowths years after initial diagnosis. In order to gain insights concerning factors associated with emergence of liver metastases, we recreated spontaneous dormancy in an all-human ex vivo hepatic microphysiological system (MPS). Seeding this MPS with small numbers (<0.05% by cell count) of the aggressive MDA-MB-231 breast cancer cell line, two populations formed: actively proliferating ('growing'; EdU+), and spontaneously quiescent ('dormant'; EdU-)...
January 20, 2018: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/29353083/combining-ultrasound-and-intratumoral-administration-of-doxorubicin-loaded-microspheres-to-enhance-tumor-cell-killing
#17
Anh-Vu Do, Sean M Geary, Dongrim Seol, Phillip Tobias, Daniel Carlsen, Nattawut Leelakanok, James A Martin, Aliasger K Salem
Melanoma is an incurable disease for which alternative treatments to chemotherapy alone are sought. Here, using a melanoma model, we investigated the antitumor potential of combining ultrasound (US) with poly(lactic-co-glycolic acid) (PLGA) microspheres loaded with doxorubicin (DOX). The aim was to achieve synergistic tumoricidal activity through direct and indirect US-mediated damage of tumor cells combined with sustained and potentially controllable release (when combined with US) of DOX from microspheres...
January 15, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29344436/exploring-laser-induced-breakdown-spectroscopy-as-a-potential-tool-in-mohs-micrography-a-mini-review
#18
REVIEW
Sandeep Singh, Rupak Desai, Mitul Modi, Showket Hussain
Mohs micrographic surgery is the technique of surgically removing skin tumors by gradually excising thin layers and visualizing under a microscope till a tumor-free zone is obtained. During the surgical procedure, visible tumors are surgically removed. During the second stage, if tumor margins are clear with the positive specimen at depth, only depth cavitations need to be done without altering the tumor diameter. Defining the depth during this procedure is a major challenge due to the nonexistence of proper guidelines...
November 13, 2017: Curēus
https://www.readbyqxmd.com/read/29344223/application-of-intensity-modulated-radiation-therapy-in-the-treatment-of-nasopharyngeal-carcinoma
#19
Hao Yan, Xiaoming Cao, Jinmei Wang
The objective of the present study was to investigate the application values of the intensity-modulated radiation therapy (IMRT) and the three-dimensional conformal radiation therapy (3D-CRT) in the treatment of nasopharyngeal carcinoma (NPC). A total of 124 patients diagnosed with nasopharyngeal carcinomas were included into the study and randomly divided into the control group and the observation group, with 62 patients in each group. The 3D-CRT combined with postoperative chemotherapy were performed on the control group and the observation group received IMRT combined with postoperative chemotherapy, and then were followed up for a median duration of 25...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29344133/improved-treatment-of-early-small-hepatocellular-carcinoma-using-sorafenib-in-combination-with-radiofrequency-ablation
#20
Quanyou Gong, Zhaoxia Qin, Fangli Hou
Small hepatocellular carcinoma is an important leading cause of death amongst cancer patients, our study was designed in order to test the hypothesis that radiofrequency ablation (RFA) combined with a chemotherapeutic drug would improve the outcome for patients. Two groups of patients presenting early small hepatocellular carcinoma were treated with either conventional RFA alone (50 individuals in the control group), or with a combination of RFA and oral sorafenib (40 individuals in an observation group). Individual clinical and laboratory evaluations were done during an average follow-up time of 35 months, and all the data recorded was used to compare results of both treatment approaches...
December 2017: Oncology Letters
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