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https://www.readbyqxmd.com/read/29666220/synergistic-anti-proliferative-effect-of-mtor-inhibitor-rad001-plus-gemcitabine-on-cholangiocarcinoma-by-decreasing-choline-kinase-activity
#1
Gigin Lin, Kun-Ju Lin, Frank Wang, Tse-Ching Chen, Tzu-Chen Yen, Ta-Sen Yeh
Although gemcitabine plus cisplatin is the gold standard chemotherapy regimen for advanced cholangiocarcinoma, the response rate has been disappointing. This study aims to investigate a novel therapeutic regimen (gemcitabine plus rad001, an mTOR inhibitor) for cholangiocarcinoma. Gemcitabine, oxaliplatin, cetuximab, and rad001 in various combinations were first evaluated in vitro using six cholangiocarcinoma cell lines. In vivo therapeutic efficacies of gemcitabine, rad001 alone and combination were further evaluated using a xenograft mouse model and a chemically induced orthotopic cholangiocarcinoma rat model...
April 12, 2018: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/29661793/cell-free-plasma-dna-for-disease-stratification-and-prognosis-in-head-and-neck-cancer
#2
Markus A Schirmer, Julia Beck, Martin Leu, Michael Oellerich, Margret Rave-Fränk, Philip D Walson, Ekkehard Schütz, Martin Canis
BACKGROUND: Clinicians face many challenges in disease stratification and outcome prediction in head and neck squamous cancer cell (HNSCC) patients. Given the limitations of currently used clinical scoring, repetitive biopsies, and imaging techniques, liquid biopsy approaches may provide valuable additional diagnostic and prognostic information. METHODS: A noninterventional, single-center observational study was performed with clinical data and plasma samples from HNSCC patients...
April 16, 2018: Clinical Chemistry
https://www.readbyqxmd.com/read/29620256/kifc1-a-novel-potential-prognostic-factor-and-therapeutic-target-in-hepatocellular-carcinoma
#3
Xiaowei Fu, Yaqiong Zhu, Bingbing Zheng, Yeqing Zou, Chao Wang, Peng Wu, Jun Wang, Haimin Chen, Pengcheng Du, Bo Liang, Lu Fang
Kinesin family member C1 (KIFC1, also known as HSET) is a minus end-directed motor protein, which is critical in centrosome clustering. The present study investigated the expression of KIFC1 in paired hepatocellular carcinoma (HCC) tissues and adjacent non-cancerous tissues from 91 patients by immunohistochemical analysis; clinical data were concomitantly collected. KIFC1 was expressed at high levels in HCC tissues, compared with that in peritumoral tissues (54.9 vs. 14.3%; P<0.01), and its expression correlated with tumor emboli, metastasis, recurrence and time of recurrence...
March 29, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29607826/tumor-recurrence-at-donor-site-of-pectoralis-major-myocutaneous-flap-with-tumor-free-primary-oral-carcinoma
#4
Rakesh Kain, Suvashis Dash
Pectoralis major myocutaneous flap is an important option for post onco reconstruction in head and neck region. Among the several complications mentioned in the literature, tumor recurrence at the donor site of flap is late and rare complication. Tumor implantation at the donor site of flap is a possible explanation. The occurrence of this type case is rare. We are reporting a case of tumor recurrences of pectoralis major myocutaneous flap donor site without presence of index tumor or detectable systemic disease...
January 2018: Gulf Journal of Oncology
https://www.readbyqxmd.com/read/29603330/a-clinical-decision-support-system-using-ultrasound-textures-and-radiologic-features-to-distinguish-metastasis-from-tumor-free-cervical-lymph-nodes-in-patients-with-papillary-thyroid-carcinoma
#5
Ali Abbasian Ardakani, Reza Reiazi, Afshin Mohammadi
OBJECTIVES: This study investigated the potential of a clinical decision support approach for the classification of metastatic and tumor-free cervical lymph nodes (LNs) in papillary thyroid carcinoma on the basis of radiologic and textural analysis through ultrasound (US) imaging. METHODS: In this research, 170 metastatic and 170 tumor-free LNs were examined by the proposed clinical decision support method. To discover the difference between the groups, US imaging was used for the extraction of radiologic and textural features...
March 30, 2018: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/29594495/evaluation-of-sentinel-lymph-node-biopsy-prior-to-axillary-lymph-node-dissection-the-role-of-isolated-tumor-cells-micrometastases-and-multifocality-multicentricity-a-retrospective-study-of-1214-breast-cancer-patients
#6
Lars Schröder, Roland Fricker, Roland Gregor Stein, Thomas Rink, Hartmut Fitz, Sebastian Blasius, Achim Wöckel, Thomas Müller
PURPOSE: Sentinel lymph node biopsy (SLNB) alone has thus become an accepted surgical approach for patients with limited axillary metastatic disease. We investigated to what extent isolated tumor cells (ITC) or micrometastasis in SLNBs is associated with proven tumor cells or metastasis in non-sentinel lymph nodes. Furthermore, we investigated the feasibility of SLNB in multifocal and multicentric tumors as both entities have been considered a contraindication for this technique. METHODS: 1214 women suffering from T1 and T2 invasive breast cancer, with clinically and sonographically insuspect axillary status and undergoing primary breast cancer surgery including SLNB and axillary staging in case of SLN (sentinel lymph node) metastases, were recruited into this multicentered study...
March 29, 2018: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29570188/-stereotactic-body-radiotherapy-of-liver-metastasis-early-experience
#7
Gerda Földi, Csaba Polgár, Zsuzsánna Zongor, Barbara Melles-Bencsik, Gábor Stelczer, Balázs Madaras, Tamás Pintér, Éva Jederán, József Lövey
Recently the prevalence of oligometastatic patients is increasing. A common site of distant spread is the liver. The standard of care is curative surgical resection, however, the resecability rate is only 10-20%. Alternatively, radiofrequency ablation (RFA) or transarterial chemoembolization (TACE) may be used. Stereotactic ablative body radiotherapy (SABRT) makes it possible to deliver curative radiation dose without radiation injury to the healthy liver tissue. We delivered SABRT to three patients with inoperable hepatic metastases...
March 23, 2018: Magyar Onkologia
https://www.readbyqxmd.com/read/29552111/imaging-and-histological-appearance-of-pleomorphic-hyalinizing-angiectatic-tumors-a-case-series-and-literature-review
#8
Couger Jimenez Jaramillo, John Wojcik, Kristy Weber, Ronnie Sebro
Pleomorphic hyalinizing angiectatic tumors (PHATs) are rare mesenchymal soft tissue tumors of uncertain lineage and intermediate malignancy. The present study assesses two cases of PHAT and discusses the histological and immunophenotypical features, as well as the imaging appearance of these tumors on ultrasound, computed tomography (CT), magnetic resonance imaging and positron emission tomography/CT scans. The current study also reviews the literature and discusses the clinical management of these tumors. Wide local excision with tumor free margins is the current recommended treatment for PHAT...
April 2018: Oncology Letters
https://www.readbyqxmd.com/read/29548872/a-rare-case-of-pediatric-vaginal-yolk-sac-tumor
#9
Michelle Lightfoot, Aylin Bilgutay, Andrew Kirsch
A 14-month-old girl was evaluated for intermittent vaginal bleeding. Vaginoscopy revealed a friable tumor, and biopsy results confirmed a yolk sac tumor. AFP was elevated (1386 ng/mL) at diagnosis but quickly normalized with chemotherapy. Twelve months after diagnosis, she remains tumor-free. Although rare, malignant tumors of the vagina must be included in the differential diagnosis of prepubertal girls who present with vaginal bleeding. Primary yolk sac tumor of the vagina is seen in girls less than 3 years of age and is treated with chemotherapy with or without surgical excision...
March 13, 2018: Urology
https://www.readbyqxmd.com/read/29543921/the-esr1-and-gpx1-gene-expression-level-in-human-malignant-and-non-malignant-breast-tissues
#10
Magdalena B Król, Michał Galicki, Peter Grešner, Edyta Wieczorek, Ewa Jabłońska, Edyta Reszka, Zbigniew Morawiec, Wojciech Wąsowicz, Jolanta Gromadzińska
BACKGROUND: The aim of this study was to establish whether the gene expression of estrogen receptor alpha (encoded by ESR1) correlates with the expression of glutathione peroxidase 1 (encoded by GPX1) in the tumor and adjacent tumor-free breast tissue, and whether this correlation is affected by breast cancer. Such relationships may give further insights into breast cancer pathology with respect to the status of estrogen receptor. METHODS: We used the quantitative real-time PCR technique to analyze differences in the expression levels of the ESR1 and GPX1 genes in paired malignant and non-malignant tissues from breast cancer patients...
March 15, 2018: Acta Biochimica Polonica
https://www.readbyqxmd.com/read/29541395/high-infiltration-of-cd68-macrophages-is-associated-with-poor-prognoses-of-head-and-neck-squamous-cell-carcinoma-patients-and-is-influenced-by-human-papillomavirus
#11
Imelda Seminerio, Nadège Kindt, Géraldine Descamps, Justine Bellier, Jérôme R Lechien, Quentin Mat, Charles Pottier, Fabrice Journé, Sven Saussez
Incidence of human papillomavirus (HPV)-related head and neck squamous cell carcinomas (HNSCCs) has increased over the last few decades. The reaction of the host immune system to these tumors remains biologically complex. Here, we investigated CD68+ macrophage numbers, reporting the prognostic value in comparison to other risk factors. We also examined CD68+ macrophage infiltration during disease progression regarding the impact of HPV infection, and we studied the role of HPV16-E6/E7 oncoproteins in CD68+ macrophage recruitment...
February 16, 2018: Oncotarget
https://www.readbyqxmd.com/read/29532864/long-non-coding-rna-kcnq1ot1-mediates-the-growth-of-hepatocellular-carcinoma-by-functioning-as-a-competing-endogenous-rna-of-mir-504
#12
Chao Li, Runchen Miao, Jingyao Zhang, Kai Qu, Chang Liu
Accumulating evidence highlights the fact that long non‑coding RNAs (lncRNAs) serve as critical factors in the growth of hepatocellular carcinoma (HCC). The dysregulation of lncRNA KCNQ1 opposite strand/antisense transcript 1 (KCNQ1OT1) has been reported in numerous human benign diseases. However, the role of KCNQ1OT1 in human HCC remains poorly understood. In this study, we demonstrated that the expression of KCNQ1OT1 was abnormally increased in HCC tissues. The ectopic high expression of KCNQ1OT1 was associated with liver cirrhosis, a larger tumor size, an advanced TNM stage, and a worse overall survival and tumor‑free survival...
March 12, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29529633/is-navigation-guided-en-bloc-resection-advantageous-compared-with-intralesional-curettage-for-locally-aggressive-bone-tumors
#13
Germán L Farfalli, Jose I Albergo, Nicolas S Piuzzi, Miguel A Ayerza, D Luis Muscolo, Lucas E Ritacco, Luis A Aponte-Tinao
BACKGROUND: The treatment of locally aggressive bone tumors is a balance between achieving local tumor control and surgical morbidity. Wide resection decreases the likelihood of local recurrence, although wide resection may result in more complications than would happen after curettage. Navigation-assisted surgery may allow more precise resection, perhaps making it possible to expand the procedure's indications and decrease the likelihood of recurrence; however, to our knowledge, comparative studies have not been performed...
March 2018: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/29529631/can-navigation-assisted-surgery-help-achieve-negative-margins-in-resection-of-pelvic-and-sacral-tumors
#14
John A Abraham, Barry Kenneally, Kamil Amer, David S Geller
BACKGROUND: Navigation-assisted resection has been proposed as a useful adjunct to resection of malignant tumors in difficult anatomic sites such as the pelvis and sacrum where it is difficult to achieve tumor-free margins. Most of these studies are case reports or small case series, but these reports have been extremely promising. Very few reports, however, have documented benefits of navigation-assisted resection in series of pelvic and sacral primary tumors. Because this technology may add time and expense to the surgical procedure, it is important to determine whether navigation provides any such benefits or simply adds cost and time to an already complex procedure...
March 2018: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/29524354/features-and-treatment-of-peritoneal-metastases-from-solid-pseudopapillary-neoplasms-of-the-pancreas
#15
Jianhui Wu, Xiuyun Tian, Bonan Liu, Chengpeng Li, Chunyi Hao
BACKGROUND Solid pseudopapillary neoplasms (SPNs) of the pancreas may present widespread peritoneal metastases, but the treatment of this malignancy has not been well described and requires further investigation. MATERIAL AND METHODS Four cases of SPN with significant peritoneal metastases in our department were operated and retrospectively summarized after long-term follow-up. Eight more cases of peritoneal metastatic SPN from the PubMed database were also included in the analysis. RESULTS Peritoneal metastases of SPNs have different gross features...
March 10, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29520667/stability-of-matrix-metalloproteinase-9-as-biological-marker-in-colorectal-cancer
#16
Andreas Jonsson, Claes Hjalmarsson, Peter Falk, Marie-Lois Ivarsson
Matrix metalloproteinases (MMPs) are believed to be of importance in the growth and spread of colorectal cancer (CRC). MMP-9 level has been suggested as a biological predictor of prognosis in CRC as well as in other types of cancer such as breast and cervical cancer. The purpose of this study was to investigate the stability over time of MMP-9 in cryopreserved plasma, colorectal tumor tissue extract and macroscopically tumor-free colon mucosa tissue extract samples. Plasma and tissue samples were taken from patients at primary CRC surgery and analyzed for MMP-9...
March 9, 2018: Medical Oncology
https://www.readbyqxmd.com/read/29520104/the-rbm38-p63-feedback-loop-is-critical-for-tumor-suppression-and-longevity
#17
Yuqian Jiang, Enshun Xu, Jin Zhang, Mingyi Chen, Elsa Flores, Xinbin Chen
The RNA-binding protein Rbm38 is a target of p63 tumor suppressor and can in-turn repress p63 expression via mRNA stability. Thus, Rbm38 and p63 form a negative feedback loop. To investigate the biological significance of the Rbm38-p63 loop in vivo, a cohort of WT, Rbm38-/ - , TAp63+/- , and Rbm38-/- ;TAp63+/- mice were generated and monitored throughout their lifespan. While mice deficient in Rbm38 or TAp63 alone died mostly from spontaneous tumors, compound Rbm38-/- ;TAp63+/- mice had an extended lifespan along with reduced tumor incidence...
March 9, 2018: Oncogene
https://www.readbyqxmd.com/read/29517496/intraoperative-immunostaining-for-cytokeratin-7-during-mohs-micrographic-surgery-demonstrates-low-local-recurrence-rates-in-extramammary-paget-s-disease
#18
Ali A Damavandy, Vitaly Terushkin, John A Zitelli, David G Brodland, Christopher J Miller, Jeremy R Etzkorn, Thuzar M Shin, Mark A Cappel, Mario Mitkov, Ali Hendi
BACKGROUND: Extramammary Paget's disease (EMPD) is a rare intraepithelial malignancy with high recurrence rates following standard surgical treatments, ranging from 22% to 60% in large retrospective reviews. OBJECTIVE: To evaluate the local recurrence rate of Mohs micrographic surgery (MMS) supplemented with intraoperative immunohistochemistry for cytokeratin-7 (MMS + CK-7) for primary and recurrent EMPD. MATERIALS AND METHODS: Retrospective, multi-center, cross-sectional study of patients treated using MMS + CK-7...
March 2018: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29512001/evaluating-the-ability-of-the-new-subclassification-to-prognosticate-outcomes-following-hepatectomy-for-patients-with-hbv-related-hcc
#19
Yunhong Tian, Huan Lyu, Yunhong He, Hari Krishna Kanduri
BACKGROUND: Recently, experts proposed subclassification for BCLC B patients. In this study, we aimed to evaluate the efficient of subclassification of patients with hepatitis B virus-related hepatocellular carcinoma (HCC) in Barcelona Clinic Liver Cancer (BCLC) staging system. METHODS: Seven hundred twenty-nine consecutive hepatitis B virus-related HCC patients with BCLC stage B classification who underwent hepatectomy in the period 2006-2012 were retrospectively analyzed...
March 7, 2018: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/29507420/how-asbestos-drives-the-tissue-towards-tumors-yap-activation-macrophage-and-mesothelial-precursor-recruitment-rna-editing-and-somatic-mutations
#20
Hubert Rehrauer, Licun Wu, Walter Blum, Lazslo Pecze, Thomas Henzi, Véronique Serre-Beinier, Catherine Aquino, Bart Vrugt, Marc de Perrot, Beat Schwaller, Emanuela Felley-Bosco
Chronic exposure to intraperitoneal asbestos triggered a marked response in the mesothelium well before tumor development. Macrophages, mesothelial precursor cells, cytokines, and growth factors accumulated in the peritoneal lavage. Transcriptome profiling revealed YAP/TAZ activation in inflamed mesothelium with further activation in tumors, paralleled by increased levels of cells with nuclear YAP/TAZ. Arg1 was one of the highest upregulated genes in inflamed tissue and tumor. Inflamed tissue showed increased levels of single-nucleotide variations, with an RNA-editing signature, which were even higher in the tumor samples...
March 6, 2018: Oncogene
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