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https://www.readbyqxmd.com/read/29113852/tumour-stem-cells-in-meningioma-a-review
#1
REVIEW
Ganeshwaran Shivapathasundram, Agadha C Wickremesekera, Swee T Tan, Tinte Itinteang
Meningioma is a common intracranial and intraspinal neoplasm accounting for 25-30% of all primary neurological tumours. It is associated with high rates of recurrence especially in higher-grade tumours and lesions located at the skull base. Cancer stem cells are increasingly recognised as the origin of cancer and are attributed to loco-regional recurrence, metastasis and treatment resistance. This review presents the accumulating evidence of the presence of tumour stem cells within meningioma and the stem cell markers being used to characterise this putative primitive population within this common tumour...
November 4, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29074286/endoscopic-surgery-of-the-olfactory-cleft
#2
R Jankowski, C Rumeau, P Gallet, D T Nguyen, A Russel, B Toussaint
The olfactory cleft is the specific site of development of many tumours (respiratory epithelial adenomatoid hamartoma, intestinal-type adenocarcinoma, neuroblastoma, inverted papilloma, glomangiopericytoma, etc.) and is also the site of CSF rhinorrhoea via the cribriform plate (cribri-rhinorrhoea). Olfactory cleft surgery must therefore be considered to be a specific type of surgery, complementary to ethmoidal labyrinth surgery and anterior skull base surgery. Olfactory cleft tumours can be resected according to five different surgical procedures: olfactory cleft mucosal resection, partial resection of the olfactory cleft, total resection of the olfactory cleft, unilateral endoscopic anterior skull base resection, and bilateral endoscopic anterior skull base resection...
October 23, 2017: European Annals of Otorhinolaryngology, Head and Neck Diseases
https://www.readbyqxmd.com/read/29064038/hypofractionated-high-energy-proton-beam-irradiation-is-an-alternative-treatment-for-who-grade-i-meningiomas
#3
Pavlos Vlachogiannis, Olafur Gudjonsson, Anders Montelius, Erik Grusell, Ulf Isacsson, Kristina Nilsson, Erik Blomquist
BACKGROUND: Radiation treatment is commonly employed in the treatment of meningiomas. The aim of this study was to evaluate the effectiveness and safety of hypofractionated high-energy proton therapy as adjuvant or primary treatment for WHO grade I meningiomas. METHOD: A total of 170 patients who received irradiation with protons for grade I meningiomas between 1994 and 2007 were included in the study. The majority of the tumours were located at the skull base (n = 155)...
October 24, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28987827/surgical-management-of-giant-intracranial-meningioma-operative-nuances-challenges-and-outcome
#4
Vinayak Narayan, Shyamal C Bir, Nasser Mohammed, Amey R Savardekar, Devi Prasad Patra, Anil Nanda
INTRODUCTION: The giant intracranial meningioma [GIM] constitutes a different spectrum of brain tumors which invade the vital neurovascular structures and makes the primary mode of treatment, surgery, a technically challenging one. The surgery of GIM is unique due to its large size, prominent vascularity, entangling and limited visualisation of various neurovascular structures and severe cerebral edema. The study reports the authors surgical experience of 80 GIM cases, the operative challenges and surgical outcome...
October 5, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28887277/single-step-resection-of-an-intraosseous-meningioma-and-cranial-reconstruction-technical-note
#5
C E Broeckx, T J J Maal, R D Vreeken, R R M Bos, M Ter Laan
OBJECTIVE: Simultaneous tumour resection and cranial reconstruction can be a challenging task. Surgical navigation is an indispensible tool in making this single-step procedure possible. In this case report we describe a new technique for this procedure to ensure a precise resection and optimal fit of the implant in a patient with an intraosseous meningioma. METHODS: We generated a 3D model of the patients skull based on a CT-scan and created a digital 'resection line' object using 3D Studio Max 2016 software...
September 5, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28883763/cyberknife-stereotactic-radiosurgery-and-denosumab-for-giant-cell-tumour-of-the-skull-base-case-report
#6
Cuauhtemoc de la Peña, Jorge H Guajardo, Maria F Gonzalez, Miguel A Hinojosa, Erick Cardona
Giant cell tumours (GCT) of the skull is a rare entity with only small number of cases reported in literature and optimal treatment is yet to be determined. These tumours have shown high recurrence rates after incomplete surgery, usually occurring during the first year. Even with new surgical techniques a complete resection in skull base tumours is not always possible without functional compromise. Therefore, adjuvant therapy is essential to enhance local control and quality of life. We report a rare case of a 34-year-old male with giant cell tumour (GCT) of the skull base involving the petrous bone, clivus and sphenoid body...
November 2017: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/28806981/understanding-the-potentiality-of-accelerator-based-boron-neutron-capture-therapy-for-osteosarcoma-dosimetry-assessment-based-on-the-reported-clinical-experience
#7
Silva Bortolussi, Ian Postuma, Nicoletta Protti, Lucas Provenzano, Cinzia Ferrari, Laura Cansolino, Paolo Dionigi, Olimpio Galasso, Giorgio Gasparini, Saverio Altieri, Shin-Ichi Miyatake, Sara J González
BACKGROUND: Osteosarcoma is the most frequent primary malignant bone tumour, and its incidence is higher in children and adolescents, for whom it represents more than 10% of solid cancers. Despite the introduction of adjuvant and neo-adjuvant chemotherapy that markedly increased the success rate in the treatment, aggressive surgery is still needed and a considerable percentage of patients do not survive due to recurrences or early metastases. Boron Neutron Capture Therapy (BNCT), an experimental radiotherapy, was investigated as a treatment that could allow a less aggressive surgery by killing infiltrated tumour cells in the surrounding healthy tissues...
August 15, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28758407/radiation-for-skull-base-meningiomas-review-of-the-literature-on-the-approach-to-radiotherapy
#8
Fabio Y Moraes, Caroline Chung
Skull base meningiomas (SBM) pose unique challenges for radiotherapy as these tumors are often in close proximity to a number of critical structures and may not be surgically addressed in many cases, leaving the question about the tumor grade and expected biological behaviour. External beam radiotherapy and radiosurgery are longstanding treatments for meningioma that are typically used as upfront primary therapy, for recurrent tumors and as adjuvant therapy following surgical resection. There is controversy regarding the optimal timing and approach for radiation therapy in various clinical settings such as the role of adjuvant radiotherapy for completely resected grade 2 tumours...
July 2017: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/28735379/multidisciplinary-management-of-clival-chordomas-long-term-clinical-outcome-in-a-single-institution-consecutive-series
#9
Petter Förander, Jiri Bartek, Michael Fagerlund, Hamza Benmaklouf, Ernest Dodoo, Alia Shamikh, Pär Stjärne, Tiit Mathiesen
OBJECTIVE: Chordomas of the skull base have high recurrence rates even after radical resection and adjuvant radiotherapy. We evaluate the long-term clinical outcome using multidisciplinary management in the treatment of clival chordomas. METHODS: Between 1984 and 2015, 22 patients diagnosed with an intracranial chordoma were treated at the Karolinska University Hospital, Stockholm, Sweden. Sixteen of 22 were treated with Gamma Knife radiosurgery (GKRS) for tumour residual or progression during the disease course...
October 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28716213/imaging-of-endoscopic-approaches-to-the-anterior-and-central-skull-base
#10
REVIEW
I M Schmalfuss
Sinonasal endoscopy for treatment of benign sinonasal diseases is a well-established procedure. Recent advances in endoscope technology have substantially expanded its application with many institutions now offering resection of skull base lesions and sinonasal malignancies via the endoscopic approach. Its minimally invasive nature leads to faster recovery time, better cosmetic results, and fewer complications. Unfortunately, not all lesions involving the sinonasal region and skull base are accessible to sinonasal endoscopy...
July 14, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/28713744/access-osteotomy-in-the-maxillofacial-skeleton
#11
REVIEW
K Kamalpathey, Maj Gen N K Sahoo, Col P K Chattopadhyay, Maj Yuvraj Issar
Surgical accesses for the facial skeleton are based on the concept of modular osteotomies. Various techniques and combination of osteotomies facilitate access to the most inaccessible tumors of craniomaxillofacial region. Most appropriate surgical access is determined by considering size, location, extension of the tumor, and experience of the surgical team. These are primarily used for tumors in the nasopharynx or the skull base. The aim of this paper is to review surgical accesses that aid in removal of inaccessible tumors of craniomaxillofacial region with series of cases operated in the Department of Oral and Maxillofacial Surgery, Armed Forces Medical College, Pune, India, between July 2008 and June 2010...
January 2017: Annals of Maxillofacial Surgery
https://www.readbyqxmd.com/read/28687916/amide-proton-transfer-imaging-for-differentiation-of-benign-and-atypical-meningiomas
#12
Bio Joo, Kyunghwa Han, Yoon Seong Choi, Seung-Koo Lee, Sung Soo Ahn, Jong Hee Chang, Seok-Gu Kang, Se Hoon Kim, Jinyuan Zhou
PURPOSE: To investigate the difference in amide proton transfer (APT)-weighted signals between benign and atypical meningiomas and determine the value of APT imaging for differentiating the two. METHODS: Fifty-seven patients with pathologically diagnosed meningiomas (benign, 44; atypical, 13), who underwent preoperative MRI with APT imaging between December 2014 and August 2016 were included. We compared normalised magnetisation transfer ratio asymmetry (nMTR asym ) values between benign and atypical meningiomas on APT-weighted images...
July 7, 2017: European Radiology
https://www.readbyqxmd.com/read/28669443/i-125-brachytherapy-guided-by-individual-three-dimensional-printed-plates-for-recurrent-ameloblastoma-of-the-skull-base
#13
J-Y Liu, Q-W Man, Y-Q Ma, B Liu
Ameloblastoma is one of the most common benign odontogenic tumours of the mandible and the maxilla. Wide excision of the tumour is the first choice for treatment (except for unicystic ones). Patients with invaded margins or unresectable lesions may require radiotherapy. Today, permanent implantation of I(125) seeds is widely used in the treatment of cancer of the head and neck. We report a case of recurrent ameloblastoma of the base of the skull that was treated with I(125) brachytherapy. The outcome has been encouraging, with total disappearance of the tumour on positron emission tomography 18 months later...
June 29, 2017: British Journal of Oral & Maxillofacial Surgery
https://www.readbyqxmd.com/read/28667597/stereotactic-radiotherapy-as-primary-definitive-or-postoperative-treatment-of-intracranial-meningioma-of-who-grade-ii-and-iii-leads-to-better-disease-control-than-stereotactic-radiotherapy-of-recurrent-meningioma
#14
Dorota Lubgan, Sandra Rutzner, Ulrike Lambrecht, Karl Rössler, Michael Buchfelder, Ilker Eyüpoglu, Rainer Fietkau, Sabine Semrau
The aim of this study was to evaluate long-term clinical outcome, prognostic factors and quality of life after adjuvant or definitive fractionated stereotactic radiotherapy (SRT) of meningioma WHO grade II and III or at recurrence. 131 patients with 138 meningioma (64 WHO grade II, 16 WHO grade III, 58 without histology) of the skull base, falx and convexity were treated between 01/2002 and 01/2015 at the Erlangen University Hospital by fractionated stereotactic radiotherapy (SRT) as primary treatment (adjuvant or definitive) and at recurrence...
June 30, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28666652/osteosarcoma-of-the-skull-base-an-analysis-of-19-cases-and-literature-review
#15
Zhifei Guo, Ke Hu, Bing Zhao, Erbao Bian, Song Ni, Jinghai Wan
BACKGROUND: Osteosarcoma of the skull base is rarely observed; most published studies comprise case reports. The clinical features and optimal treatments have not been clearly established. The purpose of this article is to present 19 cases of skull base osteosarcoma and review the literature to analyse the clinical features and treatment of skull base osteosarcoma. METHODS: The clinical data of 19 patients with skull base osteosarcoma from January 2005 to December 2016 were retrospectively analysed; pertinent English literature from 1976 to 2016 was reviewed...
October 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28655484/-anterior-skull-base-schwannoma
#16
Miguel Esquivel-Miranda, Elier De la O Ríos, Emmanuelle Vargas-Valenciano, Eva Moreno-Medina
Schwannomas are nerve sheath tumours that originate in Schwann cells. They are usually solitary and sporadic and manifest on peripheral, spinal or cranial nerves. Intracranial schwannomas tend to manifest on the eighth cranial nerve, particularly in patients with neurofibromatosis type2. Anterior skull-base schwannomas represent less than 1% of all intracranial schwannomas. They are more frequent in young people and are typically benign. These tumours represent a diagnostic challenge due to their rarity and difficult differential diagnosis, and numerous theories have been postulated concerning their origin and development...
November 2017: Neurocirugía
https://www.readbyqxmd.com/read/28631685/-the-transperygoid-approach-to-the-removal-of-a-recurrent-juvenile-angiofibroma-at-the-base-of-the-skull-without-preoperative-embolization
#17
N S Grachev, I N Vorozhtsov
The authors report a clinical case of successful elimination of a recurrent juvenile angiofibroma at the base of the skull (JAFBS) with the application of the optical navigation system and a cold plasma scalpel in the absence of preoperative embolization. It has been demonstrated using the proposed transperygoid approach to the extirpation of the tumour that a recurrent juvenile angiofibroma at the base of the skull can be efficiently removed by means of a modern minimally invasive and at the same time radical surgical method...
2017: Vestnik Otorinolaringologii
https://www.readbyqxmd.com/read/28623412/long-term-follow-up-after-endoscopic-trans-sphenoidal-surgery-or-initial-observation-in-clivus-chordomas
#18
Jon Ramm-Pettersen, Radek Frič, Jon Berg-Johnsen
BACKGROUND: Resection of clivus chordomas through extensive skull base approaches is associated with high mortality and morbidity even in experienced hands. We report our experience with endoscopic trans-sphenoidal surgery, or a "wait-and-scan" strategy in selected patients. METHOD: Ten patients were diagnosed with clivus chordomas during an 8-year period. Six patients underwent primary treatment with endoscopic trans-sphenoidal surgery, followed by adjuvant proton-beam therapy in three of these patients...
October 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28556486/endoscopic-video-assisted-transoral-resection-of-lateral-oropharyngeal-tumors
#19
Nilantha De Zoysa, Neeraj Sethi, Jemy Jose
Endoscopic, video-assisted transoral resection of oropharyngeal tumors is a novel technique carried out using common instruments present in most otolaryngology departments. The technique facilitates oropharyngeal resection akin to transoral robotic surgery (TORS) without the need for a robot. A dual surgeon approach, analogous to that of endoscopic skull base surgery is used. Each surgeon can actively participate in the resection with several key advantages over current techniques. The technique is applicable to departments internationally especially where the use of a robot is prohibited by cost or availability...
May 26, 2017: Head & Neck
https://www.readbyqxmd.com/read/28506520/the-evolving-role-of-proton-beam-therapy-for-sarcomas
#20
S Frisch, B Timmermann
As an alternative to conventional photon-based radiotherapy, radiation with protons is recognised to offer considerable advantages. Today, central nervous system tumours, various sarcomatous tumours, childhood cancer and head and neck tumours are commonly treated with proton therapy. This review evaluates current data from clinical and dosimetric trials on the treatment of selected sarcomatous tumours like rhabdomyosarcoma, osteosarcoma, chordoma, chondrosarcoma and Ewing sarcoma. Special considerations for paediatric tumours and future prospects of proton therapy are outlined...
August 2017: Clinical Oncology: a Journal of the Royal College of Radiologists
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