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https://www.readbyqxmd.com/read/29054118/efficacy-of-laryngectomy-alone-for-treatment-of-locally-advanced-laryngeal-cancer-a-stage-and-subsite-specific-survival-analysis
#1
Brian P Cervenka, Shyam Rao, D Gregory Farwell, Arnaud F Bewley
OBJECTIVE: Total laryngectomy is a well-established treatment for locally advanced laryngeal cancer. Evidence for the benefit of post-operative radiotherapy after laryngectomy in patients with locally advanced primaries and N0 or N1 nodal disease is limited. This study aims to determine whether total laryngectomy alone is adequate therapy for certain patient subgroups with locally advanced laryngeal cancer. DESIGN: We performed a retrospective survival analysis of patients in the surveillance epidemiology and end results (SEER) database with locally advanced laryngeal cancer between 2004-2012...
October 20, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29054111/dipeptidyl-peptidase-4-inhibitors-attenuates-the-decline-of-skeletal-muscle-mass-in-patients-with-type-2-diabetes
#2
Ryotaro Bouchi, Tatsuya Fukuda, Takato Takeuchi, Yujiro Nakano, Masanori Murakami, Isao Minami, Hajime Izumiyama, Koshi Hashimoto, Takanobu Yoshimoto, Yoshihiro Ogawa
BACKGROUND: Activation of dipeptidyl peptidase 4 (DPP4) has been reported to be associated with impairment of insulin signaling in skeletal muscle mass, presumably leading to loss of muscle function. This study was aimed to investigate whether the use of DPP4 inhibitors (DPP4i) could attenuate the progressive loss of muscle mass in patients with type 2 diabetes. METHODS: A total 105 patients with type 2 diabetes (mean age 62 ± 12 years; 39% female) were studied in this retrospective observational study...
October 20, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/29054109/influence-of-backside-loading-on-the-floating-mass-transducer-an-in-vitro-experimental-study
#3
Antoniu-Oreste Gostian, Martin Sylvester Otte, David Pazen, Magdalene Ortmann, David Schwarz, Karl Bernd Hüttenbrink, Dirk Beutner
HYPOTHESIS: The vibration of the floating mass transducer (FMT) of a single active middle-ear implant (AMEI) is distinctly influenced by the properties of the material coupled to its back side. BACKGROUND: In round window vibroplasty, the FMT needs to be padded against the surrounding bone opposite from the round window membrane. This represents one factor influencing its performance as a round window driver. Therefore, we examined the effects of different materials linked to the back side of an FMT on its vibration range...
October 20, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29054050/thermal-neutron-radiative-capture-on-cadmium-as-a-counting-technique-at-the-ines-beam-line-at-isis-a-preliminary-investigation-of-detector-cross-talk
#4
G Festa, F Grazzi, A Pietropaolo, A Scherillo, E M Schooneveld
Experimental tests are presented that assess the cross-talk level among three scintillation detectors used as neutron counters exploiting the thermal neutron radiative capture on Cd. The measurements were done at the INES diffractometer operating at the ISIS spallation neutron source (Rutherford Appleton Laboratory, UK). These tests follow a preliminary set of measurements performed on the same instrument to study the effectiveness of this thermal neutron counting strategy in neutron diffraction measurements, typically performed on INES using squashed (3)He filled gas tubes...
October 13, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/29054002/low-temperature-preparation-of-oxygen-deficient-tin-dioxide-nanocrystals-and-a-role-of-oxygen-vacancy-in-photocatalytic-activity-improvement
#5
Supanan Anuchai, Sukon Phanichphant, Doldet Tantraviwat, Prayoonsak Pluengphon, Thiti Bovornratanaraks, Burapat Inceesungvorn
The introduction of oxygen vacancies (Vos) into tin dioxide crystal structure has been found as an effective method to improve its photocatalytic performance. Herein, oxygen-deficient tin dioxide (SnO2-x) nanocrystals were successfully prepared via a facile, one-step hydrothermal method at the temperature lower than those reported previously. The effect of hydrothermal temperature on phase composition and Vos content was also firstly investigated. Due to its high oxygen vacancy concentration, the SnO2-x prepared at 80 °C provides the best photocatalytic degradation of methyl orange under UV-visible light...
October 13, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29053995/effects-of-a-whey-protein-supplementation-on-oxidative-stress-body-composition-and-glucose-metabolism-among-overweight-people-affected-by-diabetes-mellitus-or-impaired-fasting-glucose-a-pilot-study
#6
Chiara Flaim, Michael Kob, Angela M Di Pierro, Markus Herrmann, Lucio Lucchin
Obesity and diabetes mellitus type 2 (DM2) are characterized by chronic inflammation and oxidative stress [Donath et al. 2013] and this leads to cardiovascular diseases [Hulsmans & Holvoet 2010]. Whey proteins (WP) have antioxidant [Chitapanarux et al. 2009], anti-inflammatory [Sugawara et al. 2012] and hypoglycemic activities [Mignone et al. 2015], while data on weight, body composition [Frestedt et al. 2008; Aldrich et al. 2011] and blood pressure are conflicting [Kawase et al. 2000; Lee et al. 2007]. WP have unpleasant taste and smell [Patel 2015], but a new WP isolate (ProLYOtin®) seems to be more palatable...
May 20, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29053933/chronic-administration-of-ellagic-acid-improved-the-cognition-in-male-middle-aged-overweight
#7
Ying Liu, Shuyi Yu, Fen Wang, Haitao Yu, Xueli Li, Wanru Dong, Ruichao Lin, Qingshan Liu
This study aims to investigate whether ellagic acid has beneficial effects on cognitive deficits in middle-aged overweight individuals and the possible mechanism. A total of 150 middle-aged male participants, including 76 normal weight and 74 overweight, aged between 45 to 55 years were recruited for this study. Both normal weight and overweight participants were administered either 50 mg ellagic acid or placebo cellulose daily for 12 weeks. Blood lipids, peripheral brain-derived neurotrophic factor (BDNF) and saliva cortisol were assessed on the last day of the procedure to investigate the effects induced by ellagic acid...
October 20, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29053907/motor-performance-deterioration-accelerates-after-50-years-of-age-in-charcot-marie-tooth-type-1a-patients
#8
Stefano Tozza, Dario Bruzzese, Chiara Pisciotta, Rosa Iodice, Marcello Esposito, Raffaele Dubbioso, Lucia Ruggiero, Antonietta Topa, Emanuele Spina, Lucio Santoro, Fiore Manganelli
OBJECTIVE: The aim of our study was to describe, by a case-control and cross-sectional design, the correlation between clinical impairment and age in CMT1A patients. METHODS: We enrolled seventy CMT1A patients and seventy sex- and age-matched healthy controls. Motor performance was assessed through 10-Meter Walk Test, 6-Minute Walk Test and 9-Hole Peg Test (9HPT) of dominant and non-dominant side, and muscle strength was measured by using the Medical Research Council Score...
October 20, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29053884/looking-into-cognitive-impairment-in-primary-progressive-multiple-sclerosis
#9
Maria Petracca, James Sumowski, Michelle Fabian, Aaron Miller, Fred Lublin, Matilde Inglese
BACKGROUND: Cognitive impairment in primary-progressive multiple sclerosis (PP-MS) is correlated with global brain atrophy. Unfortunately, brain volumes computation requires processing resources not widely available in clinical practice. Therefore we decided to test the predictive role of retinal atrophy metrics on cognitive decline, applying them as proxy of grey matter (GM) atrophy in PP-MS. METHODS: Twenty-five PP-MS patients completed the Brief International Cognitive Assessment for MS (BICAMS) and underwent spectral-domain OCT and 3...
October 20, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29053883/pharmacokinetics-of-inorganic-cobalt-and-a-vitamin-b12-supplement-in-the-thoroughbred-horse-differentiating-cobalt-abuse-from-supplementation
#10
L L Hillyer, Z Ridd, S Fenwick, P Hincks, S W Paine
BACKGROUND: Whilst cobalt is an essential micronutrient for vitamin B12 synthesis in the horse, at supra-physiological concentrations it has been shown to enhance performance in humans and rats and there is evidence that its administration in high doses to horses poses a welfare threat. Animal sport regulators currently control cobalt abuse via international race day thresholds, but since cobalt may be present in physiological concentrations this work was initiated to explore means of potentially adding to application of those thresholds...
October 20, 2017: Equine Veterinary Journal
https://www.readbyqxmd.com/read/29053874/tau-pathology-and-neurodegeneration-contribute-to-cognitive-impairment-in-alzheimer-s-disease
#11
Alexandre Bejanin, Daniel R Schonhaut, Renaud La Joie, Joel H Kramer, Suzanne L Baker, Natasha Sosa, Nagehan Ayakta, Averill Cantwell, Mustafa Janabi, Mariella Lauriola, James P O'Neil, Maria L Gorno-Tempini, Zachary A Miller, Howard J Rosen, Bruce L Miller, William J Jagust, Gil D Rabinovici
Neuropathological and in vivo studies have revealed a tight relationship between tau pathology and cognitive impairment across the Alzheimer's disease spectrum. However, tau pathology is also intimately associated with neurodegeneration and amyloid pathology. The aim of the present study was therefore to assess whether grey matter atrophy and amyloid pathology contribute to the relationship between tau pathology, as measured with 18F-AV-1451-PET imaging, and cognitive deficits in Alzheimer's disease. We included 40 amyloid-positive patients meeting criteria for mild cognitive impairment due to Alzheimer's disease (n = 5) or probable Alzheimer's disease dementia (n = 35)...
October 7, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29053840/evaluation-of-neutron-scattering-correction-using-the-semi-empirical-method-and-the-shadow-cone-method-for-the-neutron-field-of-the-korea-atomic-energy-research-institute
#12
Seung Kyu Lee, Sang I Kim, Jungil Lee, Insu Chang, Jang-Lyul Kim, Hyoungtaek Kim, Min Chae Kim, Bong-Hwan Kim
When neutron survey metres are calibrated in neutron fields, the results for room- and air-scattered neutrons vary according to the distance from the source and the size, shape and construction of the neutron calibration room. ISO 8529-2 recommends four approaches for correcting these effects: the shadow-cone method, semi-empirical method, generalised fit method and reduced-fitting method. In this study, neutron scattering effects are evaluated and compared using the shadow-cone and semi-empirical methods for the neutron field of the Korea Atomic Energy Research Institute (KAERI)...
October 19, 2017: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/29053836/long-term-disability-progression-in-primary-progressive-multiple-sclerosis-a-15-year-study
#13
Maria A Rocca, Maria Pia Sormani, Marco Rovaris, Domenico Caputo, Angelo Ghezzi, Enrico Montanari, Antonio Bertolotto, Alice Laroni, Roberto Bergamaschi, Vittorio Martinelli, Giancarlo Comi, Massimo Filippi
Prognostic markers of primary progressive multiple sclerosis evolution are needed. We investigated the added value of magnetic resonance imaging measures of brain and cervical cord damage in predicting long-term clinical worsening of primary progressive multiple sclerosis compared to simple clinical assessment. In 54 patients, conventional and diffusion tensor brain scans and cervical cord T1-weighted scans were acquired at baseline and after 15 months. Clinical evaluation was performed after 5 and 15 years in 49 patients...
September 27, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29053808/the-impact-of-supplemental-antioxidants-on-visual-function-in-nonadvanced-age-related-macular-degeneration-a-head-to-head-randomized-clinical-trial
#14
Kwadwo Owusu Akuffo, Stephen Beatty, Tunde Peto, Jim Stack, Jim Stringham, David Kelly, Irene Leung, Laura Corcoran, John M Nolan
Purpose: The purpose of this study was to evaluate the impact of supplemental macular carotenoids (including versus not including meso-zeaxanthin) in combination with coantioxidants on visual function in patients with nonadvanced age-related macular degeneration. Methods: In this study, 121 participants were randomly assigned to group 1 (Age-Related Eye Disease Study 2 formulation with a low dose [25 mg] of zinc and an addition of 10 mg meso-zeaxanthin; n = 60) or group 2 (Age-Related Eye Disease Study 2 formulation with a low dose [25 mg] of zinc; n = 61)...
October 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29053806/independent-association-of-plasma-hydroxysphingomyelins-with-physical-function-in-the-atherosclerosis-risk-in-communities-aric-study
#15
Danni Li, Jeffrey R Misialek, Fangying Huang, B Gwen Windham, Fang Yu, Alvaro Alonso
Background: Plasma metabolites such as phosphatidylcholines (PCs) and sphingomyelins (SMs) are associated with in age-related cognitive decline. However, their relations to age-related physical function decline remain largely unknown. Methods: We examined the cross-sectional relations of 12 plasma metabolites (including 4 PCs and 4 SMs) with physical function in 383 older adults in the Atherosclerosis Risk in Communities study at the fifth exam (2011-13, mean age [standard deviation (SD)]: 78...
October 19, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29053805/longitudinal-measures-of-deformation-are-associated-with-a-composite-measure-of-contractility-derived-from-pressure-volume-loop-analysis-in-children
#16
Shahryar M Chowdhury, Ryan J Butts, Carolyn L Taylor, Varsha M Bandisode, Karen S Chessa, Anthony M Hlavacek, Arni Nutting, Girish S Shirali, G Hamilton Baker
Aims: The relationship between echocardiographic measures of left ventricular (LV) systolic function and reference-standard measures have not been assessed in children. The objective of this study was to assess the validity of echocardiographic indices of LV systolic function via direct comparison to a novel composite measure of contractility derived from pressure-volume loop (PVL) analysis. Methods and results: Children with normal loading conditions undergoing routine left heart catheterization were prospectively enrolled...
June 29, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/29053775/neuroinflammation-and-its-relationship-to-changes-in-brain-volume-and-white-matter-lesions-in-multiple-sclerosis
#17
Gourab Datta, Alessandro Colasanti, Eugenii A Rabiner, Roger N Gunn, Omar Malik, Olga Ciccarelli, Richard Nicholas, Eline Van Vlierberghe, Wim Van Hecke, Graham Searle, Andre Santos-Ribeiro, Paul M Matthews
Brain magnetic resonance imaging is an important tool in the diagnosis and monitoring of multiple sclerosis patients. However, magnetic resonance imaging alone provides limited information for predicting an individual patient's disability progression. In part, this is because magnetic resonance imaging lacks sensitivity and specificity for detecting chronic diffuse and multi-focal inflammation mediated by activated microglia/macrophages. The aim of this study was to test for an association between 18 kDa translocator protein brain positron emission tomography signal, which arises largely from microglial activation, and measures of subsequent disease progression in multiple sclerosis patients...
September 23, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29053774/plasma-klotho-and-frailty-in-older-adults-findings-from-the-inchianti-study
#18
Michelle Shardell, Richard D Semba, Rita R Kalyani, Stefania Bandinelli, Aric A Prather, Chee W Chia, Luigi Ferrucci
Background: The hormone klotho, encoded by the gene klotho, is primarily expressed in the kidney and choroid plexus of the brain. Higher klotho concentrations have been linked to better physical performance; however, it is unknown whether klotho relates to frailty status in older adults. Methods: Plasma klotho was measured in 774 participants aged ≥ 65 years enrolled in InCHIANTI, a prospective cohort study comprising Italian adults. Frailty status was assessed at three and six years after enrollment...
October 19, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29053750/middle-aged-individuals-with-thalidomide-embryopathy-have-undergone-few-surgical-limb-procedures-and-demonstrate-a-high-degree-of-physical-independence
#19
Shadi A Ghassemi Jahani, Aina Danielsson, Jon Karlsson, Helena Brisby
BACKGROUND: Thalidomide is known to have induced thalidomide embryopathy (TE) in more than 10,000 live-born children worldwide between 1957-1962. AIM: The aim of this study was to investigate the need for orthopaedic surgery and limb orthosis in relation to function and physical independence in middle-aged individuals with TE. METHODS: 13 women/18 men with a mean age of 45.8 (SD 1.1) years were included. Information about limb surgery, the use of orthotic devices, jobs, accommodation, disability adjustments and personal assistants was collected...
2017: PloS One
https://www.readbyqxmd.com/read/29053749/phylogeography-and-genetic-effects-of-habitat-fragmentation-on-endemic-urophysa-ranunculaceae-in-yungui-plateau-and-adjacent-regions
#20
Deng-Feng Xie, Min-Jie Li, Jin-Bo Tan, Megan Price, Qun-Ying Xiao, Song-Dong Zhou, Yan Yu, Xing-Jin He
Urophysa is a Chinese endemic genus with only two species (U. rockii and U. henryi) distributed in Yungui Plateau (Guizhou Province) and adjacent regions (i.e., Provinces of Hunan, Hubei, Chongqing and Sichuan). The aim of this study was to determine the genetic diversity and population differentiation within Urophysa and investigate the effect of the Yungui Plateau uplift and climate oscillations on evolution of Urophysa. In this study, micro-morphological characteristics, nine microsatellite loci (SSR), two nuclear loci (ITS and ETS) and two chloroplast fragments (psbA-trnH and trnL-trnF) were used to analyze the phylogenetic relationships and assess genetic and phylogeographical structure of Urophysa...
2017: PloS One
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