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https://www.readbyqxmd.com/read/29684911/high-throughput-simultaneous-quantitation-of-hemoglobin-adducts-of-acrylamide-glycidamide-and-ethylene-oxide-using-uhplc-ms-ms
#1
Min Yang, Tunde Frame, Chui Tse, Hubert W Vesper
Ethylene oxide (EO), acrylamide (AA) and glycidamide (GA) exposures are associated with mammary tumors in animals. Currently available information about human exposure to these chemicals is limited creating the need for analytical methods to assess their exposure. We developed a sensitive ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) method to simultaneously quantitate hemoglobin (Hb) N-terminal valine adducts of AA (HbAA), GA (HbGA), and EO (HbEO) using modified Edman reaction...
April 3, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29684909/hyphenation-of-size-exclusion-chromatography-to-native-ion-mobility-mass-spectrometry-for-the-analytical-characterization-of-therapeutic-antibodies-and-related-products
#2
Anthony Ehkirch, Oscar Hernandez-Alba, Olivier Colas, Alain Beck, Davy Guillarme, Sarah Cianférani
Mass spectrometry performed in non-denaturing conditions (native MS), and its hyphenation to ion mobility spectrometry (IM-MS), have gained interest for the qualitative and quantitative characterization of intact monoclonal antibody-related (mAb) products. However, one main drawback is the manual sample preparation, which hampers its routine use in high throughput automated environments. Size exclusion chromatography (SEC) appears as an interesting technique to perform online buffer exchange in an automated way...
April 12, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29684895/design-synthesis-and-biological-evaluation-of-novel-xanthine-oxidase-inhibitors-bearing-a-2-arylbenzo-b-furan-scaffold
#3
Hong-Jin Tang, Wei Li, Mei Zhou, Li-Ying Peng, Jin-Xin Wang, Jia-Huang Li, Jun Chen
Xanthine oxidase, which catalyzes the oxidative reaction of hypoxanthine and xanthine into uric acid, is a key enzyme to the pathogenesis of hyperuricemia and gout. In this study, for the purpose of discovering novel xanthine oxidase (XO) inhibitors, a series of 2-arylbenzo[b]furan derivatives (3a-3d, 4a-4o and 6a-6d) were designed and synthesized. All these compounds were evaluated their xanthine oxidase inhibitory and antioxidant activities by using in vitro enzymatic assay and cellular model. The results showed that a majority of the designed compounds exhibited potent xanthine oxidase inhibitory effects and antioxidant activities, and compound 4a emerged as the most potent xanthine oxidase inhibitor (IC50  = 4...
February 2, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29684842/shear-force-analysis-by-core-location-in-longissimus-steaks-from-nellore-cattle-using-hyperspectral-images-a-feasibility-study
#4
Juliana Monteiro Balage, José Manuel Amigo, Daniel Silva Antonelo, Madeline Rezende Mazon, Saulo da Luz E Silva
Industry requires non-destructive real-time methods for quality control of meat in order to improve production efficiency and meet consumer expectations. Near Infrared Hyperspectral Images were used for tenderness evaluation of Nellore beef and the construction of tenderness distribution maps. To investigate whether the selection of the region of interest (ROI) in the image at the exact location where the shear force core was collected improves tenderness prediction and classification models, 50 samples from Longissimus muscle were imaged (1000-2500 nm) and shear force were measured (Warner-Bratzler)...
April 12, 2018: Meat Science
https://www.readbyqxmd.com/read/29684790/is-there-evidence-to-use-kinematic-kinetic-measures-clinically-in-low-back-pain-patients-a-systematic-review
#5
REVIEW
Enrica Papi, Anthony M J Bull, Alison H McGregor
BACKGROUND: Currently, there is a widespread reliance on self-reported questionnaires to assess low back pain patients. However, it has been suggested that objective measures of low back pain patients' functional status should be used to aid clinical assessment. The aim of this study is to systematically review which kinematic /kinetic parameters have been used to assess low back pain patients against healthy controls and to propose clinical kinematic/kinetic measures. METHODS: PubMed, Embase and Scopus databases were searched for relevant studies...
April 11, 2018: Clinical Biomechanics
https://www.readbyqxmd.com/read/29684789/bipedal-hopping-timed-to-a-metronome-to-detect-impairments-in-anticipatory-motor-control-in-people-with-mild-multiple-sclerosis
#6
Megan C Kirkland, Alice Chen, Matthew B Downer, Brett J Holloway, Elizabeth M Wallack, Evan J Lockyer, Natasha C M Buckle, Courtney L Abbott, Michelle Ploughman
BACKGROUND: People with mild multiple sclerosis (MS) often report subtle deficits in balance and cognition but display no measurable impairment on clinical assessments. We examined whether hopping to a metronome beat had the potential to detect anticipatory motor control deficits among people with mild MS (Expanded Disability Status Scale ≤ 3.5). METHODS: Participants with MS (n = 13), matched controls (n = 9), and elderly subjects (n = 13) completed tests of cognition (Montreal Cognitive Assessment (MoCA)) and motor performance (Timed 25 Foot Walk Test (T25FWT))...
April 13, 2018: Clinical Biomechanics
https://www.readbyqxmd.com/read/29684768/aberrant-parasympathetic-reactivity-to-acute-psychosocial-stress-in-male-patients-with-schizophrenia-spectrum-disorders
#7
Elizabeth H Andersen, Gregory F Lewis, Aysenil Belger
Autonomic dysfunction represents a core domain of the pathophysiology of schizophrenia spectrum disorders (SCZ), with aberrant physiologic arousal underlying maladaptive social and cognitive behaviors. Antagonistic parasympathetic and sympathetic systems support autonomic flexibility to appropriately regulate arousal and respond to environmental challenges, which can be modeled using physiologic measures. SCZ patients consistently show heightened basal stress, however, their parasympathetic reactivity to an acute psychosocial stressor is poorly understood...
April 6, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29684662/release-of-endothelial-microparticles-in-patients-with-arterial-hypertension-hypertensive-emergencies-and-catheter-related-injury
#8
Roberto Sansone, Maximilian Baaken, Patrick Horn, Dominik Schuler, Ralf Westenfeld, Nicolas Amabile, Malte Kelm, Christian Heiss
BACKGROUND AND AIMS: Circulating endothelial microparticles (EMPs) are increased in arterial hypertension. The role of physicomechanical factors that may induce EMP release in vivo is still unknown. We studied the relationship of EMPs and physicomechanical factors in stable arterial hypertension and hypertensive emergencies, and investigated the pattern of EMP release after mechanical endothelial injury. METHODS: In a pilot study, 41 subjects (50% hypertensives) were recruited...
April 12, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29684658/caught-in-between-system-for-in-flow-inactivation-of-enzymes-as-an-intermediary-step-in-plug-and-play-microfluidic-platforms
#9
Ana C Fernandes, Benjamin Petersen, Lars Møller, Krist V Gernaey, Ulrich Krühne
The need for fast and comprehensive characterization of biocatalysts has pushed the development of new screening platforms based on microfluidics, capable of monitoring several parameters simultaneously, with new configurations of liquid handling, sample treatment and sensing. Modular microfluidics allows the integration of these newly developed approaches in a more flexible way towards increasing applicability of the microfluidic chips to different types of biocatalysts and reactions. A highly relevant operation in such a system is biocatalyst inactivation, which can enable the precise control of reaction time by avoiding the continuation of the reaction in another module or connecting tubes...
April 20, 2018: New Biotechnology
https://www.readbyqxmd.com/read/29684649/china-s-capacity-of-hospitals-to-deal-with-infectious-diseases-in-the-context-of-climate-change
#10
Michael Xiaoliang Tong, Alana Hansen, Scott Hanson-Easey, Jianjun Xiang, Scott Cameron, Qiyong Liu, Xiaobo Liu, Yehuan Sun, Philip Weinstein, Gil-Soo Han, Peng Bi
OBJECTIVES: Infectious diseases are a major cause of morbidity and mortality in China. The capacity of hospitals to deal with the challenge from emerging and re-emerging infectious diseases due to climate change is of great importance to population health. This study aimed to explore the capacity of hospitals in China to deal with such challenges. METHODS: A cross-sectional questionnaire survey was utilized to gauge information regarding capacity of hospitals to deal with infectious diseases in the context of climate change among 611 clinical professionals whose roles pertained to infectious disease diagnosis, treatment and management in Anhui Province of China...
April 16, 2018: Social Science & Medicine
https://www.readbyqxmd.com/read/29684646/granger-geweke-causality-estimation-and-interpretation
#11
Mukesh Dhamala, Hualou Liang, Steven L Bressler, Mingzhou Ding
In a recent PNAS article1 , Stokes and Purdon performed numerical simulations to argue that Granger-Geweke causality (GGC) estimation is severely biased, or of high variance, and GGC application to neuroscience is problematic because the GGC measure is independent of 'receiver' dynamics. Here, we use the same simulation examples to show that GGC measures, when properly estimated either via the spectral factorization-enabled nonparametric approach or the VAR-model based parametric approach, do not have the claimed bias and high variance problems...
April 20, 2018: NeuroImage
https://www.readbyqxmd.com/read/29684604/effect-of-antiaggregants-on-the-in-vitro-viability-cell-count-and-stability-of-abalone-haliotis-iris-haemocytes
#12
Roffi Grandiosa, Mai-Louise Bouwman, Tim Young, Fabrice Mérien, Andrea C Alfaro
The ability to successfully prepare and preserve haemocyte cells for microscopy and flow cytometry is critical for the investigation of animal immune systems. In this study, we observed the total cell count, in vitro viability and stability of New Zealand black-footed abalone (Haliotis iris) haemocytes with different antiaggregants and handling protocols. Haemocyte stability was evaluated by direct observation of haemocytes under the microscope and calculating the aggregation index. Haemocyte counts and viability were measured via flow cytometry and tested for the effect of different antiaggregants (Alsever's solution at three concentrations, and specialised blood collection tubes containing lithium heparin and K2 EDTA) at different temperatures and storage times...
April 20, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29684536/gender-related-functional-connectivity-and-craving-during-gaming-and-immediate-abstinence-during-a-mandatory-break-implications-for-development-and-progression-of-internet-gaming-disorder
#13
Guangheng Dong, Ziliang Wang, Yifan Wang, Xiaoxia Du, Marc N Potenza
BACKGROUND: Although males more frequently develop Internet gaming disorder (IGD) as compared with females, few studies have examined gender-related neurocognitive differences in IGD. TASK AND DESIGN: fMRI and subjective data were collected from 119 subjects (IGD, male 29, female 25; recreational game use (RGU), male 34, female 31) when they were actively playing games and during a forced mandatory break. Analyses investigating effects of group (IGD, RGU) and gender (male, female) on the functional connectivity (FC) of executive control and reward systems linked to the dorsolateral prefrontal cortex (DLPFC) and striatum, respectively, were performed...
April 20, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29684387/duodenoscope-reprocessing-practice-patterns-in-u-s-endoscopy-centers-a-survey-study
#14
Adarsh M Thaker, V Raman Muthusamy, Alireza Sedarat, Rabindra R Watson, Michael L Kochman, Andrew S Ross, Stephen Kim
BACKGROUND AND AIMS: After recent outbreaks of duodenoscope-related infections from multidrug-resistant organisms (MDRO), the United States Food and Drug Administration (FDA) recommended implementing one or more of four enhanced reprocessing measures in addition to updated manual cleaning methods and high-level disinfection (HLD). The implementation of these techniques in endoscopy facilities and provider opinions regarding reprocessing priorities remain unknown. METHODS: Physicians, nurse managers, nurses, and infection control staff at endoscopy units performing ERCP in the United States were surveyed to assess current institutional practices and individual opinions regarding future reprocessing solutions...
April 20, 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29684370/analytical-validation-and-investigation-on-reference-intervals-of-aldosterone-and-renin-in-chinese-han-population-by-using-fully-automated-chemiluminescence-immunoassays
#15
Lingyan Deng, Zhigang Xiong, Huijun Li, Xiaomei Lei, Liming Cheng
BACKGROUND: The aldosterone/renin ratio (ARR) is recommended to screen for primary aldosteronism (PA) in hypertension. We estimated fully automated chemiluminescence immunoassays (CLIA) for plasma aldosterone concentrations (PAC) and plasma direct renin concentrations (PRC) and investigated their reference intervals in Chinese Han population. METHODS: PAC and PRC were measured on a fully automated analyzer (LIAISON XL, DiaSorin, Italy). Performance characteristics were estimated according to CLSI proved guidelines...
April 20, 2018: Clinical Biochemistry
https://www.readbyqxmd.com/read/29684350/down-regulation-of-traf4-targeting-rsk4-inhibits-proliferation-invasion-and-metastasis-in-breast-cancer-xenografts
#16
Lingyu Zhu, Suisui Zhang, Xuejie Huan, Yan Mei, Huawei Yang
Ribosomal S6 protein kinase 4 (RSK4) was known as a novel tumor suppressor gene, and the tumor necrosis factor receptor-associated factor 4 (TRAF4) was linked to carcinogenesis. The purpose of this study is to further investigate the effect of the TRAF4 gene on cell proliferation, invasion and metastasis in vivo and explore whether there is an interaction between TRAF4 and RSK4 in breast cancer. MDA-MB-231 cells were transfected with lentivirus TRAF4-shRNA to specifically block the expression of TRAF4, or transfected with lentivirus negative-shRNA as a negative control...
April 20, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29684257/reliability-of-neurometabolite-detection-with-two-dimensional-localized-correlation-spectroscopy-at-3t
#17
Jameen Arm, Oun Al-Iedani, Scott Quadrelli, Karen Ribbons, Rod Lea, Jeannette Lechner-Scott, Saadallah Ramadan
BACKGROUND: Two-dimensional localized correlational spectroscopy (2D L-COSY) has been applied in vivo to investigate metabolic profiles in many disorders due to its ability to detect several metabolites simultaneously. Successful application of this technique depends on the reliability of the detection and understanding of the variability result from test-retest measurements. PURPOSE: To evaluate the test-retest repeatability/reliability of 2D L-COSY in detecting brain metabolites in a phantom and healthy subjects in a 3T scanner...
April 23, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29684249/standard-head-down-tilt-versus-modified-without-head-down-tilt-postural-drainage-in-infants-and-young-children-with-cystic-fibrosis
#18
REVIEW
Diana A Freitas, Gabriela Ss Chaves, Thayla A Santino, Cibele Td Ribeiro, Fernando Al Dias, Ricardo O Guerra, Karla Mpp Mendonça
BACKGROUND: Postural drainage is used primarily in infants with cystic fibrosis from diagnosis up to the moment when they are mature enough to actively participate in self-administered treatments. However, there is a risk of gastroesophageal reflux associated with this technique.This is an update of a review published in 2015. OBJECTIVES: To compare the effects of standard postural drainage (15º to 45º head-down tilt) with modified postural drainage (15º to 30º head-up tilt) with regard to gastroesophageal reflux in infants and young children up to six years old with cystic fibrosis in terms of safety and efficacy...
March 9, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29684224/mismatch-negativity-and-cortical-thickness-in-patients-with-schizophrenia-and-bipolar-disorder
#19
Sungkean Kim, Hyeonjin Jeon, Kuk-In Jang, Yong-Wook Kim, Chang-Hwan Im, Seung-Hwan Lee
Introduction: Mismatch negativity (MMN) is a measure of automatic neurophysiological brain processes for detecting unexpected sensory stimuli. This study investigated MMN reduction in patients with schizophrenia and bipolar disorder and examined whether cortical thickness is associated with MMN, for exploratory purposes. Methods: Electroencephalograms were recorded in 38 patients with schizophrenia, 37 patients with bipolar disorder, and 32 healthy controls (HCs) performing a passive auditory oddball paradigm...
April 19, 2018: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/29684197/impact-of-sow-energy-status-during-farrowing-on-farrowing-kinetics-frequency-of-stillborn-piglets-and-farrowing-assistance
#20
T Feyera, T F Pedersen, U Krogh, L Foldager, P K Theil
Farrowing duration is rather long in sows most likely due to selection for large litters, and we hypothesized that prolonged farrowings would compromise sow energy status during farrowing and in turn the farrowing process. Two studies were performed 1) to evaluate whether sow energy status during farrowing compromise the farrowing kinetics (FK, i.e. farrowing duration and birth intervals) and 2) to study the underlying mechanisms potentially affecting stillbirth rate and farrowing assistance. In study-1, parameters affecting FK were characterized based on data from a total of 166 farrowings from 7 feeding trials focused on sow colostrum production...
April 19, 2018: Journal of Animal Science
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