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https://www.readbyqxmd.com/read/29245184/evaluation-of-the-use-of-novel-biomarkers-to-augment-antimicrobial-stewardship-program-activities
#1
Kayla R Stover, Rachel M Kenney, Travis S King, Alan E Gross
As antimicrobial stewardship increasingly receives worldwide attention for improving patient care by optimizing antimicrobial therapy, programs are evaluating new tools that may augment antimicrobial stewardship activities. Biomarkers are objective, accurate, and reproducible measures that provide information about medical conditions. A systematic literature search using PubMed/MEDLINE databases was performed to evaluate the use of novel biomarkers as additions to the antimicrobial stewardship armamentarium...
December 15, 2017: Pharmacotherapy
https://www.readbyqxmd.com/read/29245124/bisphenol-and-phthalate-concentrations-and-its-determinants-among-pregnant-women-in-a-population-based-cohort-in-the-netherlands-2004-5
#2
Elise M Philips, Vincent W V Jaddoe, Alexandros G Asimakopoulos, Kurunthachalam Kannan, Eric A P Steegers, Susana Santos, Leonardo Trasande
BACKGROUND: Exposure to bisphenols and phthalates in pregnancy may lead to adverse health effects in women themselves and their offspring. OBJECTIVE: To describe first trimester bisphenol and phthalate urine concentrations, including bisphenol and phthalate replacements, and determine nutritional, socio-demographic and lifestyle related determinants. METHODS: In a population-based prospective cohort of 1396 mothers, we measured first trimester bisphenol, phthalate and creatinine urine concentrations (samples collected in 2004-2005, median gestational age 12...
December 12, 2017: Environmental Research
https://www.readbyqxmd.com/read/29245113/the-temporal-relationship-between-activity-of-the-pelvic-floor-muscles-and-motion-of-selected-urogenital-landmarks-in-healthy-nulliparous-women
#3
Stéphanie Thibault-Gagnon, Cindy Auchincloss, Ryan Graham, Linda McLean
AIMS: The purpose of this study was to investigate the relationship between pelvic floor muscle (PFM) electromyographic (EMG) activation and urogenital landmark motion measured using 2D transperineal ultrasound (US) imaging. METHODS: Eight healthy, nulliparous women performed maximum voluntary PFM contractions while EMG and transperineal US images were acquired simultaneously. Changes in the levator plate length (LPL), bladder neck (BN) position and urethral position were determined by visual inspection...
December 6, 2017: Journal of Electromyography and Kinesiology
https://www.readbyqxmd.com/read/29245107/impacts-on-the-seagrass-zostera-nigricaulis-from-the-herbicide-fusilade-forte%C3%A2-used-in-the-management-of-spartina-anglica-infestations
#4
Megan Carve, Timothy L Coggan, Jackie H Myers, Bradley Clarke, Dayanthi Nugegoda, Jeff Shimeta
The herbicide Fusilade Forte® (FF) is widely applied in agricultural weed management and in the management of the invasive saltmarsh grass, Spartina anglica (ricegrass or cordgrass). FF (active ingredient fluazifop-P acid, FPA) is selective for poaceous grasses. Its primary mode of action is inhibition of the acetyl coenzyme-A carboxylase (ACCase) specific to this taxonomic group, and its secondary mode is by promotion of oxidative stress. FF is applied to S. anglica infestations in the intertidal zone, in proximity to seagrass meadows...
December 1, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/29245096/pre-and-post-operative-evaluation-of-pincer-type-femoroacetabular-impingement-during-squat-using-image-matching-techniques-a-case-report
#5
Kensei Yoshimoto, Satoshi Hamai, Hidehiko Higaki, Hirotaka Gondo, Satoru Ikebe, Yasuharu Nakashima
INTRODUCTION: Although combined evaluation of hip joint kinematics and bone morphology is necessary for accurate assessment of femoroacetabular impingement (FAI), there are no report which evaluated hip kinematics of pincer-type FAI. PRESENTATION OF CASE: The pre- and postoperative hip kinematics of a 46-year-old man, with a pincer-type FAI during squat were evaluated using image-matching techniques and the rim-neck distance was measured. Preoperative simulation of squatting was also performed using patient's bone models and healthy subject's kinematics data to detect the overlapping lesion between the acetabulum and the femur...
December 8, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29245093/neurocognitive-functioning-in-first-episode-bipolar-disorder-relationship-with-functional-status
#6
Alejandro G Szmulewicz, Marina P Valerio, Julieta Lomastro, José M Smith, Virginia Chiappe, Diego J Martino, Ana Igoa
BACKGROUND: The aim of this study was to assess if an association between neurocognitive deficits and psychosocial functioning exists in first-episode BD patients. METHODS: Twenty-five euthymic first-episode BD patients and thirty-seven healthy controls were recruited. History of suicide attempts, psychiatric comorbidities, pharmacological exposure, and previous depressive episodes were investigated. Performances on neurocognitive domains (verbal memory, attention, processing speed, and executive functions) as well as a measure of psychosocial functioning were used as outcomes...
December 8, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29245062/comparative-studies-on-dna-binding-and-in-vitro-antitumor-activity-of-enantiomeric-ruthenium-ii-complexes
#7
Wen-Xu Hong, Fengwen Huang, Tianwen Huan, Xu Xu, Qingguo Han, Gaofeng Wang, Hong Xu, Shan Duan, Yongheng Duan, Xun Long, Ying Liu, Zhangli Hu
A pair of ruthenium(II) complex enantiomers, Δ- and Λ-[Ru(bpy)2PBIP]2+ {bpy=2,2'-bipyridine, PBIP=2-(4-bromophenyl)imidazo[4,5-f]1,10-phenanthroline} have been synthesized and characterized. The systematic comparative studies between two enantiomers on their DNA binding-behaviors with calf thymus DNA (CT DNA) were carried out by viscosity measurements, spectrophotometric methods and molecular simulation technology. Additional assays were performed to explore the cytotoxicity of the ruthenium(II) enantiomers against tumor cell lines...
November 29, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/29245028/on-site-evaluation-of-wagyu-beef-carcasses-based-on-the-monounsaturated-oleic-and-saturated-fatty-acid-composition-using-a-handheld-fiber-optic-near-infrared-spectrometer
#8
S Piao, T Okura, M Irie
The fat quality is an important aspect, especially for Wagyu beef. A handheld fiber-optic near-infrared spectrometer for on-site evaluation of beef fat quality was developed, and the interactance spectra of the intermuscular fat from 833 Wagyu carcasses at 12 markets were measured. The calibration model was transferred to five slave instruments using twenty-six block samples. The performance of one slave instrument was verified at five meat markets (n=360). The coefficients of determination of the slave instrument for monounsaturated, oleic, and saturated fatty acid compositions determined by gas chromatography and near-infrared measurements were 0...
November 27, 2017: Meat Science
https://www.readbyqxmd.com/read/29244994/do-perceived-needs-affect-willingness-to-use-traditional-chinese-medicine-for-survivorship-care-among-chinese-cancer-survivors-a-cross-sectional-survey
#9
Lingyun Sun, Yufei Yang, Emily Vertosick, SungHwa Jo, Guilan Sun, Jun J Mao
Purpose We aimed to quantify Chinese cancer survivors' perceived needs for survivorship care and to evaluate whether these needs could impact their willingness to use traditional Chinese medicine (TCM). Methods We conducted a cross-sectional survey with members of the Beijing Anti-Cancer Association in China. We measured perceived needs with the seven-item Brief Chinese Cancer Survivorship Needs Scale that assesses psychological, functional, nutritional, social, body image, pain, and symptom needs. The outcome variable was willingness to use TCM for survivorship care...
December 2017: Journal of Global Oncology
https://www.readbyqxmd.com/read/29244947/a-new-strategy-for-in-vitro-determination-of-carbonic-anhydrase-activity-from-analysis-of-oxygen-18-isotopes-of-co2
#10
Chiranjit Ghosh, Santanu Mandal, Mithun Pal, Manik Pradhan
The oxygen-18 isotopic (18O) composition in CO2 provides important insight into the variation of rate in isotopic fractionation reaction regulated by carbonic anydrase (CA) metalloenzyme. This work aims to employ 18O-isotope ratio-based analytical method for quantitative estimation of CA activity in erythrocytes for clinical testing purposes. Here, a new method has been developed that contains the measurements of 18O/16Oisotope ratios during oxygen-18 isotopic exchange between 12C16O16O and H218O of in-vitro biochemical reaction controlled by erythrocytes CA and estimation of enzymatic activity of CA from the isotopic composition of CO2...
December 15, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29244894/the-concealed-information-test-is-susceptible-to-misleading-information
#11
Katja Volz, Lisa-Marie Bahr, Markus Heinrichs, Dieter Vaitl, Wolfgang Ambach
An approach toward detecting hidden knowledge is the Concealed Information Test (CIT). It relies on the memory of crime-relevant information. This study investigated whether its validity is susceptible to memory distortion by misleading information. A misleading information paradigm was employed to distort memory prior to an interrogation with a CIT. Forty-one participants watched a video with specific crime-related information. After a 1-week retention interval, misleading information was introduced. Afterward, a CIT was performed, followed by a threefold memory test...
December 15, 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/29244891/the-effects-of-experimental-temporalis-muscle-pain-on-jaw-muscle-electromyographic-activity-during-jaw-movements-and-relationships-with-some-psychological-variables
#12
Tantry Maulina, Magda Amhamed, Terry Whittle, John Gal, Rahena Akhter, Greg M Murray
AIMS: To determine if the effects of experimental temporalis muscle pain on jaw muscle activity vary with the jaw task performed, jaw displacement magnitude, participant being studied, and with psychological measures. METHODS: Jaw movement was tracked, and electromyographic (EMG) activity was recorded from the masseter and anterior temporalis and digastric muscles in 14 asymptomatic participants during standardized opening/closing jaw movement, free chewing, and standardized chewing tasks...
December 15, 2017: Journal of Oral & Facial Pain and Headache
https://www.readbyqxmd.com/read/29244874/maximum-walking-speed-in-multiple-sclerosis-assessed-with-visual-perceptive-computing
#13
Anuschka Grobelny, Janina R Behrens, Sebastian Mertens, Karen Otte, Sebastian Mansow-Model, Theresa Krüger, Elona Gusho, Judith Bellmann-Strobl, Friedemann Paul, Alexander U Brandt, Tanja Schmitz-Hübsch
BACKGROUND: Gait is often impaired in people with multiple sclerosis (PwMS), but detailed assessment of gait impairment in research and care remains challenging. In a previous pilot study we reported the feasibility of visual perceptive computing (VPC) for gait assessment in PwMS using the Short Maximum Speed Walk (SMSW), which assesses gait on recording distances confined to less than 4 meters. OBJECTIVE: To investigate the equivalence of SMSW to rater-based timed 25ft...
2017: PloS One
https://www.readbyqxmd.com/read/29244861/reliability-of-the-parameters-of-the-power-duration-relationship-using-maximal-effort-time-trials-under-laboratory-conditions
#14
Christoph Triska, Bettina Karsten, Bernd Heidegger, Bernhard Koller-Zeisler, Bernhard Prinz, Alfred Nimmerichter, Harald Tschan
The purpose of this study was to assess the reliability of critical power (CP) and the total amount of work accomplished above CP (W´) across repeated tests using ecologically valid maximal effort time-trials (TT) under laboratory conditions. After an initial incremental exercise test, ten well-trained male triathletes (age: 28.5 ± 4.7 years; body mass: 73.3 ± 7.9 kg; height: 1.80 ± 0.07 m; maximal aerobic power [MAP]: 329 ± 41 W) performed three testing sessions (Familiarization, Test I and Test II) each comprising three TT (12, 7, and 3 min with a passive recovery of 60 min between trials)...
2017: PloS One
https://www.readbyqxmd.com/read/29244828/involvement-of-phenoloxidase-in-browning-during-grinding-of-tenebrio-molitor-larvae
#15
Renske H Janssen, Catriona M M Lakemond, Vincenzo Fogliano, Giovanni Renzone, Andrea Scaloni, Jean-Paul Vincken
Insects are investigated as alternative protein source to meet the increasing demand for proteins in the future. Enzymatic browning occurring during grinding of insect and subsequent extraction of proteins can influence the proteins' properties, but it is unclear which enzymes are responsible for this phenomenon. This study was performed on larvae of three commonly used insect species, namely Tenebrio molitor, Alphitobius diaperinus and Hermetia illucens. Oxygen consumption measurements on protein extracts showed activity on L-tyrosine, L-3,4-di-hydroxy-phenylalanine (L-DOPA) and L-dopamine, indicating phenoloxidase as a key player in browning...
2017: PloS One
https://www.readbyqxmd.com/read/29244809/hiv-1-viraemia-and-drug-resistance-amongst-female-sex-workers-in-soweto-south-africa-a-cross-sectional-study
#16
Jenny Coetzee, Gillian Hunt, Maya Jaffer, Kennedy Otwombe, Lesley Scott, Asiashu Bongwe, Johanna Ledwaba, Sephonono Molema, Rachel Jewkes, Glenda E Gray
BACKGROUND: HIV drug resistance (HIVDR) poses a threat to future antiretroviral therapy success. Monitoring HIVDR patterns is of particular importance in populations such as sex workers (SWs), where documented HIV prevalence is between 34-89%, and in countries with limited therapeutic options. Currently in South Africa, there is a dearth in evidence and no ongoing surveillance of HIVDR amongst sex work populations. This study aims to describe the prevalence of HIVDR amongst a sample of female sex workers (FSWs) from Soweto, South Africa...
2017: PloS One
https://www.readbyqxmd.com/read/29244769/effects-of-uv-ozone-treatment-on-sensing-behaviours-of-egfets-with-al%C3%A2-o%C3%A2-sensing-film
#17
Cuiling Sun, Ruixue Zeng, Junkai Zhang, Zhi-Jun Qiu, Dongping Wu
The effects of UV-ozone (UVO) treatment on the sensing behaviours of extended-gate field-effect transistors (EGFETs) that use Al₂O₃ as the sensing film have been investigated. The Al₂O₃ sensing films are UVO-treated with various duration times and the corresponding EGFET sensing behaviours, such as sensitivity, hysteresis, and long-term stability, are electrically evaluated under various measurement conditions. Physical analysis is also performed to characterize the surface conditions of the UVO-treated sensing films using X-ray photoelectron spectroscopy and atomic force microscopy...
December 15, 2017: Materials
https://www.readbyqxmd.com/read/29244753/identification-of-a-multicomponent-traditional-herbal-medicine-by-hplc-ms-and-electron-and-light-microscopy
#18
Ju-Han Liu, Yung-Yi Cheng, Chen-Hsi Hsieh, Tung-Hu Tsai
BACKGROUND: Commercial pharmaceutical herbal products have enabled people to take traditional Chinese medicine (TCM) in a convenient and accessible form. However, the quantity and quality should be additionally inspected. To address the issue, a combination of chemical and physical inspection methods were developed to evaluate the amount of an herbal formula, Xiang-Sha-Liu-Jun-Zi-Tang (XSLJZT), in clinical TCM practice. METHODS: A high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS) method with electrospray ionization was developed to measure the herbal biomarkers of guanosine, atractylenolide III, glycyrrhizic acid, dehydrocostus lactone, hesperidin, and oleanolic acid from XSLJZT...
December 15, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29244749/serum-levels-of-s100b-and-nse-proteins-in-patients-with-non-transfusion-dependent-thalassemia-as-biomarkers-of-brain-ischemia-and-cerebral-vasculopathy
#19
Aikaterini Kanavaki, Konstantinos Spengos, Maria Moraki, Polyxeni Delaporta, Catherine Kariyannis, Ioannis Papassotiriou, Antonis Kattamis
Patients with non-transfusion-dependent thalassemia (NTDT) are at risk of developing brain ischemia. Transcranial Doppler (TCD) has been established as a useful screening tool of cerebrovascular disease in patients with sickle cell disease. Proteins neuron specific enolase (NSE) and S100B are biomarkers that reflect CNS injury. The purpose of this study is to evaluate cerebral vessel vasculopathy and brain damage in NTDT patients using non-invasive methods as TCD and measurement serum levels of NSE and S100B...
December 15, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29244743/hematological-and-hemodynamic-responses-to-acute-and-short-term-creatine-nitrate-supplementation
#20
Ryan L Dalton, Ryan J Sowinski, Tyler J Grubic, Patrick B Collins, Adriana M Coletta, Aimee G Reyes, Brittany Sanchez, Majid Koozehchian, Yanghoon P Jung, Christopher Rasmussen, Mike Greenwood, Peter S Murano, Conrad P Earnest, Richard B Kreider
In a double-blind, crossover, randomized and placebo-controlled trial; 28 men and women ingested a placebo (PLA), 3 g of creatine nitrate (CNL), and 6 g of creatine nitrate (CNH) for 6 days. Participants repeated the experiment with the alternate supplements after a 7-day washout. Hemodynamic responses to a postural challenge, fasting blood samples, and bench press, leg press, and cycling time trial performance and recovery were assessed. Data were analyzed by univariate, multivariate, and repeated measures general linear models (GLM)...
December 15, 2017: Nutrients
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