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https://www.readbyqxmd.com/read/28821554/developing-standards-for-the-development-of-glaucoma-virtual-clinics-using-a-modified-delphi-approach
#1
Aachal Kotecha, Simon Longstaff, Augusto Azuara-Blanco, James F Kirwan, James Edwards Morgan, Anne Fiona Spencer, Paul J Foster
PURPOSE: To obtain consensus opinion for the development of a standards framework for the development and implementation of virtual clinics for glaucoma monitoring in the UK using a modified Delphi methodology. METHODS: A modified Delphi technique was used that involved sampling members of the UK Glaucoma and Eire Society (UKEGS). The first round scored the strength of agreement to a series of standards statements using a 9-point Likert scale. The revised standards were subjected to a second round of scoring and free-text comment...
August 18, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28820164/cyclophotocoagulation-induced-sympathetic-ophthalmia-in-a-coats-disease-patient-supported-by-histopathology-and-immunohistochemistry
#2
Pritam Bawankar, Dipankar Das, Shahinur Tayab, Ganesh Chandra Kuri, Jnanankar Medhi, Manabjyoti Barman, Ronel Soibam, Harsha Bhattacharjee, Panna Deka, Diva Kant Misra, Shriya Dhar
We describe a case of a 13-year-old male patient of Coats' disease who developed sympathetic ophthalmia (SO) following contact diode laser cyclophotocoagulation. There was no history of invasive surgery or any perforating injuries preceding cyclodestructive therapy. The eye had neovascular glaucoma secondary to Coats' disease, which was treated once with contact cyclophotocoagulation. Subsequently, the intraocular pressure slowly decreased, and the eye became phthisical. Intraocular inflammation developed in the fellow eye and SO was suspected, which was confirmed by characteristic findings seen on fluorescein angiography...
August 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28816820/factors-that-influence-of-trabectome-surgery-for-glaucoma-patients
#3
Naoki Tojo, Shinya Abe, Atsushi Hayashi
BACKGROUND: The aim of this study was to investigate the factors that influence the outcome of trabectome surgery. METHODS: This was a retrospective nonrandomized study. Seventy-eight glaucoma patients (86 eyes) who underwent trabectome surgeries and were followed up for more than 12 months were included. We classified the subtypes of glaucoma as: primary open-angle glaucoma (23 eyes), pseudo-exfoliation glaucoma (58 eyes), and secondary glaucoma (5 eyes). Forty-seven eyes underwent cataract and trabectome surgeries simultaneously, and 39 underwent only trabectome surgery...
August 14, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28814824/cataract-surgery-in-patients-with-pseudoex-foliation-syndrome-current-updates
#4
REVIEW
Luigi Fontana, Marco Coassin, Alfonso Iovieno, Antonio Moramarco, Luca Cimino
Pseudoexfoliation is a ubiquitous syndrome of multifactorial origin affecting elderly people by increasing the risk of cataract and secondary glaucoma development. Despite modern techniques and technologies for cataract surgery, pseudoexfoliation syndrome represents a challenge for surgeons because of the increased weakness of the zonular apparatus and limited pupil dilation. Due to the inherent difficulties during surgery, the risk of vitreous loss in these patients is several times higher than in cataract patients without pseudoexfoliation...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28814200/all-atom-molecular-dynamics-comparison-of-disease-associated-zinc-fingers
#5
Ryan C Godwin, William H Gmeiner, Freddie R Salsbury
An important regulatory domain of NEMO is a ubiquitin-binding zinc finger, with a tetrahedral CYS3HIS1 zinc-coordinating binding site. Two variations of NEMO's zinc finger are implicated in various disease states including ectodermal dysplasia and adult-onset glaucoma. To discern structural and dynamical differences between these disease states, we present results of 48-$\mu s$ of molecular dynamics simulations for three zinc finger systems each in two states, with and without zinc-bound and correspondingly appropriate cysteine thiol/thiolate configurations...
August 17, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/28807635/sustained-benefits-of-ranibizumab-with-or-without-laser-in-branch-retinal-vein-occlusion-24-month-results-of-the-brighter-study
#6
Ramin Tadayoni, Sebastian M Waldstein, Francesco Boscia, Heinrich Gerding, Margarita Gekkieva, Elizabeth Barnes, Ayan Das Gupta, Andreas Wenzel, Ian Pearce
PURPOSE: To evaluate the long-term (24-month) efficacy and safety of ranibizumab 0.5 mg administered pro re nata (PRN) with or without laser using an individualized visual acuity (VA) stabilization criteria in patients with visual impairment due to macular edema secondary to branch retinal vein occlusion (BRVO). DESIGN: Phase IIIb, open-label, randomized, active-controlled, 3-arm, multicenter study. PARTICIPANTS: A total of 455 patients. METHODS: Patients were randomized (2:2:1) to ranibizumab 0...
August 11, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28797085/comparison-of-cytokine-profiles-in-the-aqueous-humor-of-eyes-with-pseudoexfoliation-syndrome-and-glaucoma
#7
Justus G Garweg, Souska Zandi, Isabel B Pfister, Magdalena Skowronska, Christin Gerhardt
PURPOSE: To compare the cyto- and chemokine profiles in the aqueous humor of PEXS eyes in the absence or presence of secondary glaucoma with or without luxation of the intraocular lens (IOL). METHODS: Samples of aqueous humor were collected intraoperatively from 20 healthy controls and from 73 eyes with PEX-syndrome, which was manifested in the absence of any other local or systemic desease. The latter group was sub-devided into eyes with an early form of PEX-syndrome in the absence of complications (PEX, n = 33), those with a late form of PEX-syndrome and glaucoma (PEXG, n = 30), and those with a late form of PEX-syndrome with luxation of the IOL that required surgery (PEXL, n = 10)...
2017: PloS One
https://www.readbyqxmd.com/read/28796875/optical-coherence-tomography-analysis-based-prediction-of-humphrey-24-2-visual-field-thresholds-in-patients-with-glaucoma
#8
Zhihui Guo, Young H Kwon, Kyungmoo Lee, Kai Wang, Andreas Wahle, Wallace L M Alward, John H Fingert, Daniel I Bettis, Chris A Johnson, Mona K Garvin, Milan Sonka, Michael D Abràmoff
Purpose: A pilot study showed that prediction of individual Humphrey 24-2 visual field (HVF 24-2) sensitivity thresholds from optical coherence tomography (OCT) image analysis is possible. We evaluate performance of an improved approach as well as 3 other predictive algorithms on a new, fully independent set of glaucoma subjects. Methods: Subjects underwent HVF 24-2 and 9-field OCT (Heidelberg Spectralis) testing. Nerve fiber (NFL), and ganglion cell and inner plexiform (GCL+IPL) layers were cosegmented and partitioned into 52 sectors matching HVF 24-2 test locations...
August 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28777225/the-relation-between-endothelial-nitric-oxide-synthase-polymorphisms-and-normal-tension-glaucoma
#9
Jin Wook Jeoung, Dong Myung Kim, Sohee Oh, Jee-Soo Lee, Sung Sup Park, Ji Yeon Kim
PURPOSE: We investigated whether polymorphisms of the endothelial NO synthase (eNOS) gene are associated with normal tension glaucoma (NTG). We also investigated whether the eNOS polymorphisms are associated with NTG subgroups (NTG with and without optic disc hemorrhage (DH)). METHODS: A total of 251 patients with NTG and 245 healthy volunteers were enrolled in this study. DNA from peripheral blood leukocytes was extracted, and the genotypes of four polymorphisms (rs2070744, rs1549758, rs1799983, and rs2566514) in the eNOS gene were determined using restriction fragment length polymorphism and the SNaPshot method...
August 2, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28764212/congenital-ectropion-uveae-with-glaucoma-a-case-report
#10
Rashmi Kumari, Bhawesh Chandra Saha, Bibhuti Prasanna Sinha
Congenital Ectropion Uveae (CEU) is a rare anomaly characterised by ectropion uveae, iris hypoplasia, iridotrabecular dysgenesis and glaucoma. Hyperplasia of the iris pigment epithelium and its apparent spread over the anterior surface of the iris is supposed to cause the classic ectropion uveae in CEU. Almost all patients develop open angle glaucoma due to angle dysgenesis, so they should be carefully examined periodically for its early detection. We hereby report a case of isolated unilateral CEU without any systemic association which is quite uncommon...
June 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28764211/a-rare-case-of-topiramate-induced-secondary-acute-angle-closure-glaucoma
#11
Ajit Kamalakar Joshi, Amit Hemant Pathak, Saurabh Dilip Patwardhan, Anil Narayan Kulkarni
Secondary Acute Angle Closure Glaucoma (AACG) is a known side effect of Topiramate (TPM). Here, we present a case report of a 47-year-old male who was started on TPM 25 mg/day for migraine. He presented to the ophthalmology department of our hospital with sudden blurring of vision and colored halos after one day of starting TPM. A high index of suspicion, followed by appropriate investigations and prompt management that helped to manage TPM induced bilateral AACG with quick and complete visual recovery.
June 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28753216/strabismus-after-ocular-surgery
#12
Ethan K Sobol, Jamie B Rosenberg
Many types of ocular surgery can cause diplopia, including eyelid, conjunctival, cataract, refractive, glaucoma, retinal, and orbital surgery. Mechanisms include direct injury to the extraocular muscles from surgery or anesthesia, scarring of the muscle complex and/or conjunctiva, alteration of the muscle pulley system, mass effects from implants, and muscle displacement. Diplopia can also result from a loss of fusion secondary to long-standing poor vision in one eye or from a decompensation of preexisting strabismus that was not recognized preoperatively...
July 28, 2017: Journal of Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/28750481/aqueous-shunts-for-glaucoma
#13
REVIEW
Victoria L Tseng, Anne L Coleman, Melinda Y Chang, Joseph Caprioli
BACKGROUND: Aqueous shunts are employed to control intraocular pressure (IOP) for people with primary or secondary glaucomas who fail or are not candidates for standard surgery. OBJECTIVES: To assess the effectiveness and safety of aqueous shunts for reducing IOP in glaucoma compared with standard surgery, another type of aqueous shunt, or modification to the aqueous shunt procedure. SEARCH METHODS: We searched CENTRAL (which contains the Cochrane Eyes and Vision Trials Register) (2016, Issue 8), MEDLINE Ovid (1946 to August 2016), Embase...
July 28, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28750434/-26-years-of-the-erlangen-glaucoma-registry-demographic-and-perimetric-characteristics-of-patients-through-the-ages
#14
Bettina Hohberger, Edith Monczak, Christian Yahya Mardin
Background The history of the Erlangen Glaucoma Registry goes back 26 years. In this study, we present retrospective demographic and perimetric data on the initial visit of patients with ocular hypertension (OHT), pre-perimetric (prePOAG) and perimetric primary open-angle glaucoma (POAG), normal tension glaucoma (NTG) and secondary open-angle glaucoma (SOAG) and correlate these results with the latest perimetric data. Material and Methods 1406 (754 patients) of the Erlangen Glaucoma Registry (EGR; NTC00494923) were investigated retrospectively between 1991 and 2016 covering: demographic data (age, visual acuity, intraocular pressure [IOP]), diagnosis and perimetric characteristics (mean defect [MD], loss variance [LV]) at the initial visit and the latest perimetric data...
July 27, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28745006/nevus-of-ota-oculodermal-melanocytosis-in-a-dog
#15
Pedro Malho, Anita Shea, David Donaldson
A 5-year-old, female, spayed Rhodesian Ridgeback presented with ocular melanocytosis and skin hyperpigmentation involving the distribution of the first and second divisions of the trigeminal nerve on the right side of the face. The dermatomal pattern of the hyperpigmentation was similar to nevus of Ota or oculodermal melanocytosis reported in humans. This condition has been associated with increased risk of developing secondary glaucoma and melanoma transformation in skin, ocular, orbital tissues, and the central nervous system...
July 25, 2017: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/28733929/outcomes-of-ahmed-glaucoma-valve-implantation-for-steroid-induced-elevated-intraocular-pressure-in-patients-with-retinitis-pigmentosa
#16
Umit Eksioglu, Caglar Oktem, Gulten Sungur, Mehmet Yakin, Gulizar Demirok, Firdevs Ornek
PURPOSE: To evaluate the outcomes of Ahmed glaucoma valve (AGV) in the management of elevated intraocular pressure (IOP) secondary to steroid use for macular edema in patients with retinitis pigmentosa (RP). METHODS: A total of nine eyes of five patients were evaluated retrospectively. Complete success was defined as IOP ≤ 21 mmHg without glaucoma medications, while qualified success was defined as IOP ≤ 21 mmHg with glaucoma medications. RESULTS: Mean age at surgery was 25...
July 21, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28729832/the-role-of-microglia-in-retinal-neurodegeneration-alzheimer-s-disease-parkinson-and-glaucoma
#17
REVIEW
Ana I Ramirez, Rosa de Hoz, Elena Salobrar-Garcia, Juan J Salazar, Blanca Rojas, Daniel Ajoy, Inés López-Cuenca, Pilar Rojas, Alberto Triviño, José M Ramírez
Microglia, the immunocompetent cells of the central nervous system (CNS), act as neuropathology sensors and are neuroprotective under physiological conditions. Microglia react to injury and degeneration with immune-phenotypic and morphological changes, proliferation, migration, and inflammatory cytokine production. An uncontrolled microglial response secondary to sustained CNS damage can put neuronal survival at risk due to excessive inflammation. A neuroinflammatory response is considered among the etiological factors of the major aged-related neurodegenerative diseases of the CNS, and microglial cells are key players in these neurodegenerative lesions...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28728861/-vitiligo-occurring-on-dermal-melanocytosis-nevus-of-ota-in-a-dark-skinned-patient
#18
K-C Ahogo, I-P Gbery, B Vagamon, O-A Ouattara, K-A Kouassi, H-S Kourouma, Y-I Kouassi
BACKGROUND: Nevus of Ota is a rare disease most frequently found in Asians. It presents clinically as a bluish gray hyperpigmentation of one side of the face. Transformation into melanoma and glaucoma are the main risks. The appearance of vitiligo lesions with poliosis within a nevus of Ota is exceptional. PATIENTS AND METHODS: A 22-year-old female patient with a nevus of Ota consulted for depigmentation of the eyelashes. Physical examination revealed hyperpigmentation in the right orbitofrontal part of her face, achromic macules and eyelash poliosis...
July 17, 2017: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/28724812/use-of-glycerol-preserved-corneas-for-corneal-transplants
#19
Neeti Gupta, Prerna Upadhyay
PURPOSE: This study was carried out to see the results of glycerol-preserved cornea (GPC) in emergency situation when fresh corneal tissue was not available. The aim was to study the outcome of corneal transplantation using GPC. METHODS: This was a retrospective study. The medical records of all the patients were reviewed, who underwent keratoplasty using "GPC" during the period from October 2011 to December 2015. The indication of keratoplasty, duration of preservation of the GPC, and its outcome were analyzed...
July 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28721823/genetic-risk-factors-for-glaucoma-and-exfoliation-syndrome-identified-by-genome-wide-association-studies
#20
Yoichi Sakurada, Fumihiko Mabuchi
Glaucoma is a neurodegenerative disease characterized by the progressive loss of retinal ganglion cells and optic nerve axons. According to its anatomical features, glaucoma is mainly subdivided into primary open-angle glaucoma (POAG) and primary angle-closure glaucoma (PACG). Exfoliation syndrome (XFS) and glaucoma (XFG) are characterized by the accumulation of extracellular materials in ocular tissues, particularly the lens surface and pupillary border. In addition to the two major forms of glaucoma, XFG is the most common cause of secondary open-angle glaucoma...
July 18, 2017: Current Neuropharmacology
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