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https://www.readbyqxmd.com/read/28100482/mitomycin-c-augmented-trabeculectomy-subtenon-injection-versus-soaked-sponges-a-randomised-clinical-trial
#1
Mohammad Pakravan, Hamed Esfandiari, Shahin Yazdani, Azadeh Douzandeh, Nassim Amouhashemi, Mehdi Yaseri, Parto Pakravan
BACKGROUND/AIMS: To compare the efficacy and safety of subtenon injection of mitomycin C (MMC) with that of conventional application of MMC-soaked sponges in trabeculectomy. METHODS: In this multicentre randomised clinical trial, 80 consecutive open-angle glaucoma cases were randomised into two groups; group 1 received a subtenon injection of 0.1 mL of 0.01% MMC, while group 2 received 0.02% MMC-soaked sponges. Primary outcome measure was intraocular pressure (IOP), and secondary outcome measures were endothelial cell count (ECC) changes and bleb morphology according to the Indiana Bleb Appearance Grading Scale...
January 18, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28087548/early-lens-extraction-with-intraocular-lens-implantation-for-the-treatment-of-primary-angle-closure-glaucoma-an-economic-evaluation-based-on-data-from-the-eagle-trial
#2
Mehdi Javanbakht, Augusto Azuara-Blanco, Jennifer M Burr, Craig Ramsay, David Cooper, Claire Cochran, John Norrie, Graham Scotland
OBJECTIVE: To investigate the cost-effectiveness of early lens extraction with intraocular lens implantation for the treatment of primary angle closure glaucoma (PACG) compared to standard care. DESIGN: Cost-effectiveness analysis alongside a multicentre pragmatic two-arm randomised controlled trial. Patients were followed-up for 36 months, and data on health service usage and health state utility were collected and analysed within the trial time horizon. A Markov model was developed to extrapolate the results over a 5-year and 10-year time horizon...
January 13, 2017: BMJ Open
https://www.readbyqxmd.com/read/28068950/corneal-hysteresis-in-patients-with-glaucoma-like-optic-discs-ocular-hypertension-and-glaucoma
#3
Melissa L Murphy, Olya Pokrovskaya, Marie Galligan, Colm O'Brien
BACKGROUND: To compare corneal hysteresis (CH) measurements between patients with glaucoma, ocular hypertension (OHT) and glaucoma-like optic discs (GLD)- defined as a cup to disc ratio greater than or equal to 0.6 with normal intraocular pressure (IOP) and visual fields. The secondary aim was to investigate whether corneal resistance factor (CRF) and central corneal thickness (CCT) differ between patient groups. METHODS: In this cross sectional study a total of 123 patients (one eye each) were recruited from a glaucoma outpatient department to undergo ocular response analyser (ORA) testing and ultrasound pachymetry as well as clinical examination...
January 10, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28062196/radiotherapeutic-and-surgical-management-of-iris-melanoma-a-review
#4
REVIEW
Marko Popovic, Iqbal Ike K Ahmed, Julia DiGiovanni, Carol L Shields
We compare outcomes following radiotherapeutic and surgical management of iris melanoma. Endpoints included local tumor recurrence, metastases, and common complications. From an initial search that yielded 231 articles, we found 17 relevant studies with 761 eyes. The gender distribution was balanced with a mean age of 52 years. Most studies focused on either proton beam (49.4%) or plaque (31.4%) radiotherapy. Rates of local recurrence (range: 0-8%) and metastatic development (0-5%) were favorable following radiotherapy; however, common complications included cataract (36-73%), glaucoma (3-92%) and corneal conditions (0-33%)...
January 3, 2017: Survey of Ophthalmology
https://www.readbyqxmd.com/read/28056057/flat-anterior-chamber-after-trabeculectomy-in-secondary-angle-closure-glaucoma-with-best1-gene-mutation-case-series
#5
Yimin Zhong, Xinxing Guo, Hui Xiao, Jingyi Luo, Chengguo Zuo, Xiaobo Huang, Jingjing Huang, Lan Mi, Qingjiong Zhang, Xing Liu
PURPOSE: Trabeculectomy has been regarded as a mainstay of initial treatment in eyes of angle closure glaucoma (ACG) with peripheral anterior synechia > 180° in the Chinese population while its efficacy in secondary ACG with BEST1 gene mutation remains unclear. We set out to investigate the treatment outcome of trabeculectomy for secondary ACG in a group of patients with autosomal recessive bestrophinopathy (ARB). METHODS: In this retrospective case series study, 8 secondary ACG patients with ARB and their 4 recruited family members underwent a thorough ophthalmic examination including best-corrected visual acuity, Goldmann applanation tonometry, gonioscopy, and fundus examinations...
2017: PloS One
https://www.readbyqxmd.com/read/28030545/longitudinal-analysis-of-serum-autoantibody-reactivities-in-patients-with-primary-open-angle-glaucoma-and-optic-disc-hemorrhage
#6
Katrin Lorenz, Sabine Beck, Munir M Keilani, Joanna Wasielica-Poslednik, Norbert Pfeiffer, Franz H Grus
BACKGROUND: The aim of our current investigation was to analyze the autoantibody-reactivities of primary open angle glaucoma patients with optic disc hemorrhage as possibly correlated to disease progression by means of a protein microarray approach. METHODS: Sera of patients with primary open angle glaucoma and optic disc hemorrhage (n = 16) were collected directly after study inclusion (0 weeks) and after 2 weeks, 4 weeks and 12 weeks. As a control group patients with primary open angle glaucoma (n = 18) were used (0 weeks and 12 weeks)...
2016: PloS One
https://www.readbyqxmd.com/read/28017486/outcomes-and-complications-after-phacoemulsification-in-retinoblastoma-patients-with-cataract-after-radiation-treatment
#7
M Velásquez-Aguilar, H Matiz-Moreno, M Amato-Almanza, C Y Chen-López, G Márquez-García, M A Ramírez-Ortiz
PURPOSE: To describe the visual outcome and complications associated with phacoemulsification in patients with bilateral retinoblastoma (Rb), with lens opacification secondary to external beam radiotherapy. METHODS: A descriptive study was performed on patients with Rb, treated in Federico Gomez Children's Hospital, Mexico, from January 1997 to August 2015, with external beam radiotherapy eye salvaging. Statistical analysis was performed using Stata 10. RESULTS: A total of 15 patients were included...
December 22, 2016: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/28012873/posner-schlossman-syndrome
#8
REVIEW
Roly Megaw, Pankaj Kumar Agarwal
Posner-Schlossman syndrome (PSS), or glaucomatocyclitic crisis, is a unilateral ocular condition characterized by recurrent attacks of non-granulomatous anterior uveitis and raised intraocular pressure that can result in chronic secondary glaucoma. This relatively rare disease is most likely the result of recurrent cytomegalovirus infection and affects predominantly middle-aged males . Diagnosis is largely clinical, with aqueous and blood sampling aiding the identification of any underlying infectious cause...
December 21, 2016: Survey of Ophthalmology
https://www.readbyqxmd.com/read/28005810/a-rare-patient-with-orbital-apex-syndrome-anterior-uveitis-and-necrotizing-scleritis-due-to-herpes-zoster-ophthalmicus
#9
Erdinc Aydin, Melike Balikoglu-Yilmaz, Seher Saritepe Imre, Feray Koc, Levent Kazanci, Arif Taylan Ozturk
The purpose of this study was to describe a patient of orbital apex syndrome, anterior uveitis, secondary glaucoma, corneal dellen, and necrotizing scleritis following an attack of herpes zoster ophthalmicus, and the placement of a pericardial patch graft. A 64-year-old male patient with blepharoptosis of his right eye and multiple vesicles on the forehead, nose and cheeks, limitation on all gazes, blepharoptosis, and exophthalmia was eventually diagnosed with ophthalmic zona with orbital apex syndrome. After the treatment with systemic antiviral and steroid, there was complete recovery of the unilateral vesicular eruption, ophthalmoplegia, and ptosis at the third month follow-up...
November 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28002286/macular-microcysts-in-schwartz-matsuo-syndrome
#10
Xuejing Chen, Grace M Richter, Joseph Caprioli, Tara A McCannel
PURPOSE: To describe a case of macular microcysts associated with advanced secondary glaucoma from Schwartz-Matsuo syndrome. METHODS: Clinical presentation, color fundus photography, optic disk photography, visual fields, and optical coherence tomography are presented. RESULTS: A 32-year-old woman presented with advanced, unilateral secondary glaucoma associated with a macula-on rhegmatogenous retinal detachment. She was diagnosed with Schwartz-Matsuo syndrome...
December 20, 2016: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/28002194/spontaneous-dislocation-of-trabeculectomy-scleral-flap-in-the-anterior-chamber-in-a-patient-with-pseudoxanthoma-elasticum
#11
Lina Danieliute, Myrto Tsagkataki, Eleni Nikita
We report a case of a 54-year-old man, known to have pseudoxanthoma elasticum (PXE), who had a trabeculectomy in his left eye for secondary glaucoma following blunt trauma. Ten years after augmented trabeculectomy, the patient presented to casualty clinic with an inferiorly dislocated, anterior chamber (AC), scleral trabeculectomy flap. Corrected vision was hand movement with an intraocular pressure of 17 mm Hg. There was significant AC inflammation (cells 2+). Gonioscopy revealed a residual mobile scleral flap...
December 20, 2016: Journal of Glaucoma
https://www.readbyqxmd.com/read/27990116/combined-acute-haemolytic-and-secondary-angle-closure-glaucoma-following-spontaneous-intraocular-haemorrhages-in-a-patient-on-warfarin
#12
Walter Andreatta, Stavroula Boukouvala, Atul Bansal
BACKGROUND: To report the first described case of combined haemolytic and acute angle closure glaucoma secondary to spontaneous intraocular haemorrhages in a patient on excessive anticoagulation. To the best of our knowledge, this is the first case reported in the literature presenting with raised intraocular pressure due to both mechanisms. CASE DESCRIPTION: A 90-year-old woman presented with acute pain and reduction in vision in the left eye. Her intraocular pressure (IOP) was 55 mm Hg...
September 2016: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/27979014/inhaled-corticosteroids-ocular-safety-and-the-hypothalamic-pituitary-adrenal-axis
#13
Warner W Carr, Stanley J Szefler
BACKGROUND: Inhaled corticosteroids (ICSs) effectively deliver corticosteroids to target sites in the lungs and reduce systemic effects compared with oral corticosteroids, but long-term systemic exposure from inhaled corticosteroids remains a concern. OBJECTIVE: To discuss ICS systemic effects on the eye and the hypothalamic-pituitary-adrenal (HPA) axis. METHODS: Relevant publications were used to augment discussion. RESULTS: The most common adverse effects of exogenous corticosteroids on the eye are secondary open-angle glaucoma and posterior subcapsular cataracts...
December 2016: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/27978460/clinical-characteristics-of-headache-or-facial-pain-prior-to-the-development-of-acute-herpes-zoster-of-the-head
#14
Hye Lim Lee, Minju Yeo, Gi Hwa Choi, Ji Yeoun Lee, Ji Seon Kim, Dong-Ick Shin, Sang-Soo Lee, Sung-Hyun Lee
OBJECTIVES: When physicians encounter patients with headache or facial pain (preeruptive pain) associated with acute herpes zoster of the head, especially before the appearance of characteristic skin eruptions (preeruptive phase), they typically find it difficult to make clinical impressions and apply appropriate diagnostic or therapeutic procedures. The objectives of this study were to describe the clinical characteristics of headache or facial pain associated with acute herpes zoster of the head and to elucidate the association between the manifestation of these symptoms in the preeruptive phase and incoming herpes zoster...
January 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/27977576/outcome-of-primary-trabeculotomy-ab-interno-trabectome-surgery-in-patients-with-steroid-induced-glaucoma
#15
Philip Ngai, Grace Kim, Garrick Chak, Ken Lin, Masahiro Maeda, Sameh Mosaed
To determine the efficacy and safety of Trabectome surgery on patients with steroid response, ranging from ocular hypertension refractory to maximal medical therapy to the development of steroid-induced glaucoma.A nonrandomized, nonblinded, retrospective study of 20 subjects with steroid response was conducted. All 20 eyes underwent Trabectome surgery alone. Nine subjects had steroid response with unremarkable visual field, 3 had mild steroid-induced glaucoma, and 8 had advanced steroid-induced glaucoma. Outcome measures included intraocular pressure (IOP), number of glaucoma medications, need for secondary glaucoma surgery, and steroid regimen...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27968868/timing-and-approaches-in-congenital-cataract-surgery-a-randomised-controlled-trial
#16
Weirong Chen, Erping Long, Jingjing Chen, Zhenzhen Liu, Zhuoling Lin, Qianzhong Cao, Xiaohang Wu, Qiwei Wang, Duoru Lin, Xiaoyan Li, Lixia Luo, Bo Qu, Haotian Lin, Yizhi Liu
BACKGROUND: The optimum timing of surgery and the approach that should be used during congenital cataract surgery are controversial and present challenges for paediatric cataract surgeons in China. The aim of this study was to compare visual prognoses and postoperative adverse effects of paediatric cataract surgery done at different times and using different surgical approaches. METHODS: In this prospective, randomised controlled trial, we recruited Chinese patients aged 3 months or younger who were diagnosed with bilateral diffuse or total cataracts, but who did not have coexisting ocular, systemic or neurological diseases...
October 2016: Lancet
https://www.readbyqxmd.com/read/27941047/cataract-surgery-in-children-with-retinopathy-of-prematurity-rop-surgical-outcomes
#17
Chinyelu Nkemdilim Ezisi, Ramesh Kekunnaya, Subhadra Jalali, Divya Balakrishnan, Padmaja Kumari Rani, Ashik Mohamed, Preeti Patil Chhablani
PURPOSE: To report the outcomes of cataract surgery in children with retinopathy of prematurity (ROP). METHODS: A retrospective case review of all children diagnosed with ROP from January 2001 to December 2014 was done and those who underwent cataract surgery were included in the study. Details of ROP and cataract treatment, postoperative complications and outcomes were analysed. RESULTS: Of the 2258 children diagnosed to have ROP, 28 eyes of 22 children were included, 14 boys and 8 girls...
December 9, 2016: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/27921133/-evaluation-of-correction-formulas-for-tonometry-the-goldmann-applanation-tonometry-in-approximation-to-dynamic-contour-tonometry
#18
J Wachtl, M Töteberg-Harms, S Frimmel, C Kniestedt
BACKGROUND: Accurate determination of intraocular pressure (IOP) is essential for correct management of glaucoma. Goldmann applanation tonometry (GAT) is the gold standard for measuring IOP despite its limitations due to its dependence on corneal properties. With the aim of improving the accuracy of GAT readings, several correction formulas have been developed. OBJECTIVE: The aim of this study was to investigate the accuracy and clinical relevance of five correction equations for GAT...
December 5, 2016: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/27907042/role-of-platelet-parameters-on-neovascular-glaucoma-a-retrospective-case-control-study-in-china
#19
Shengjie Li, Wenjun Cao, Xinghuai Sun
PURPOSE: Retinal vein occlusion (RVO) and diabetic retinopathy (DR) are two major sight-threatening diseases which may lead to neovascular glaucoma (NVG). The aim of this study was to explore the association between platelet parameters and NVG. METHODS: A total of 185 subjects were enrolled for the study from January, 2012 to December, 2015 at the Eye-ENT Hospital of Fudan University. Patients include those with NVG secondary to RVO (RVO group, n = 38), patients with NVG secondary to DR (DR group, n = 47), diabetics mellitus without retinopathy (DM group, n = 52), and healthy individuals (control group, n = 48)...
2016: PloS One
https://www.readbyqxmd.com/read/27906814/prevalence-and-visual-outcome-of-glaucoma-with-uveitis-in-a-thai-population
#20
Kessara Pathanapitoon, Sarunya Smitharuck, Paradee Kunavisarut, Aniki Rothova
OBJECTIVE: The aim of this study was to report on the prevalence of uveitic secondary glaucoma (USG) and ocular hypertension in patients with uveitis in Thailand, and to identify factors associated with the development of USG and its visual outcome. DESIGN: This is a retrospective cohort study. METHODS: We included 174 consecutive uveitis patients (237 affected eyes) visiting the Ophthalmology Department of Chiang Mai University Hospital, Thailand, from January 2013 to March 2013...
November 30, 2016: Journal of Glaucoma
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