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https://www.readbyqxmd.com/read/29765422/the-effect-of-pulsatile-flow-on-bmsc-derived-endothelial-like-cells-in-a-small-sized-artificial-vessel-made-by-3-dimensional-bioprinting
#1
Kang Woog Lee, Dae-Hyun Kim, Jun Hee Lee, Young-Nam Youn
Replacement of small-sized vessels is still challenging. This study is aimed at investigating the possibility of small-sized artificial vessels made by 3-dimensional bioprinting and the effect of pulsatile flow on bMSC-derived endothelial-like cells. Cells were harvested from rabbit bone marrow and primary cultured with or without growth factors. Endothelial differentiation was confirmed by the Matrigel tube formation assay, Western blot, and qRT-PCR. In addition, embedment of endothelial-like cells in an artificial vessel was made by 3-dimensional bioprinting, and the pulsatile flow was performed...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29758129/twenty-four-hour-normothermic-perfusion-of-discarded-human-kidneys-with-urine-recirculation
#2
Annemarie Weissenbacher, Letizia Lo Faro, Olga Boubriak, Maria F Soares, Ian S Roberts, James P Hunter, Daniel Voyce, Nikolay Mikov, Andrew Cook, Rutger J Ploeg, Constantin C Coussios, Peter J Friend
Transportable normothermic kidney perfusion for 24 hours or longer could enable viability assessment of marginal grafts, increased organ utilization and improved transplantation logistics. Eleven clinically-declined kidneys were perfused normothermically, six from donors after brain stem death (DBD, median cold ischemia time 33±36.9 hours) and five from donors after circulatory death (DCD, 36.2±38.3 hours): n=3 kidneys were perfused using Ringer's lactate to replace excreted urine volume, and n=8 using urine recirculation to maintain perfusate volume without fluid replenishment...
May 14, 2018: American Journal of Transplantation
https://www.readbyqxmd.com/read/29757447/humic-acid-and-enzymes-inclusion-in-canola-based-diets-generate-different-responses-in-growth-performance-protein-utilization-dynamics-and-hemato-biochemical-parameters-in-broiler-chickens
#3
A R P Disetlhe, U Marume, V Mlambo
The current study was conducted to investigate the effect of a humic acid and enzymes on growth performance, protein utilization, and blood parameters in broilers fed canola-based diets. Canola meal (CM) is characterized as low protein compared to soybean meal. Two-hundred-twenty broiler chickens were randomly allotted to the following 5 dietary treatments: 1. Control (commercial broiler diet); 2. CM (17.5% canola meal inclusion); 3. CMEnz (CM + 0.3 g/kg enzymes [Axtra XAP]); 4. CMPh (CM + 1.5% potassium humate, PH) and 5...
May 10, 2018: Poultry Science
https://www.readbyqxmd.com/read/29729039/effects-of-calcium-and-sodium-on-atp-induced-vasopressin-release-from-rat-isolated-neurohypophysial-terminals
#4
E E Custer, T K Knott, S Ortiz-Miranda, J R Lemos
ATP-receptors (P2X2, P2X3, P2X4 & P2X7) are found in neurohypophysial terminals (NHT). These purinergic receptor subtypes are known to be cation selective. Here we confirm that both sodium (Na+ ) and calcium (Ca2+ ) are permeable through these NHT purinergic receptors, but to varying degrees (91% vs. 9%, respectively). Furthermore, extracellular calcium inhibits the ATP-current magnitude. Thus, the objective of this study was to determine the effects of extracellular Na+ vs. Ca2+ on ATP-induced vasopressin (AVP) release from populations of rat isolated NHT...
May 4, 2018: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/29727896/prednisolone-dosages-in-addisonian-dogs-after-integration-of-acth-measurement-into-treatment-surveillance
#5
Florian K Zeugswetter, Tanja Haninger
OBJECTIVE: To examine the prednisolone and fludrocortisone dosages in dogs with primary hypoadrenocorticism after integrating endogenous ACTH (eACTH) determination into the surveillance regimen. MATERIALS AND METHODS: The local electronic medical records database was searched for dogs with primary hypoadrenocorticism and a complete follow-up including routine eACTH measurements until stabilisation. Dogs were considered stable if they showed no signs of glucocorticoid deficiency or excess, sodium and potassium were within the laboratory reference limits and no change of prednisolone and/or fludrocortisone dosage was recommended by the clinician...
April 2018: Tierärztliche Praxis. Ausgabe K, Kleintiere/Heimtiere
https://www.readbyqxmd.com/read/29725222/effects-of-jerusalem-artichoke-powder-and-sodium-carbonate-as-phosphate-replacers-on-the-quality-characteristics-of-emulsified-chicken-meatballs
#6
Burcu Öztürk, Meltem Serdaroğlu
Today incorporation of natural ingredients as inorganic phosphate replacers has come into prominence as a novel research topic due to health concerns about phosphates. In this study, we aimed to investigate the quality of emulsified chicken meatballs produced with Jerusalem artichoke powder (JAP), either alone or in combination with sodium carbonate (SC) as sodium tripolyphosphate (STPP) replacers. The results showed that naturally dried JAP showed favorable technological properties in terms of water-oil binding and gelling...
February 2018: Korean Journal for Food Science of Animal Resources
https://www.readbyqxmd.com/read/29722966/sodium-hyaluronate-chitosan-composite-microneedles-as-a-single-dose-intradermal-immunization-system
#7
Yu-Hsiu Chiu, Mei-Chin Chen, Shu-Wen Wan
Enhancing the immune response to vaccines and minimizing the need for repeated inoculations remain a challenge in clinical vaccination. This study developed a composite microneedle (MN), composed of a sodium hyaluronate (HA) tip and a chitosan base, for biphasic antigen release and evaluated the potential of using this MN formulation as an intradermal delivery system for single-dose vaccination. Upon skin insertion, the dissolvable HA tip dissolved within the skin for rapid release of the encapsulated antigens, thus priming the immune system, while the biodegradable chitosan base remained in the dermis for prolonged antigen release for 4 weeks, thus further boosting the stimulated immunity...
May 3, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29717417/hydrogen-sulfide-ameliorates-aging-associated-changes-in-the-kidney
#8
Hak Joo Lee, Denis Feliers, Jeffrey L Barnes, Sae Oh, Goutam Ghosh Choudhury, Vivian Diaz, Veronica Galvan, Randy Strong, James Nelson, Adam Salmon, Christopher G Kevil, Balakuntalam S Kasinath
Aging is associated with replacement of normal kidney parenchyma by fibrosis. Because hydrogen sulfide (H2 S) ameliorates kidney fibrosis in disease models, we examined its status in the aging kidney. In the first study, we examined kidney cortical H2 S metabolism and signaling pathways related to synthesis of proteins including matrix proteins in young and old male C57BL/6 mice. In old mice, increase in renal cortical content of matrix protein involved in fibrosis was associated with decreased H2 S generation and AMPK activity, and activation of insulin receptor (IR)/IRS-2-Akt-mTORC1-mRNA translation signaling axis that can lead to increase in protein synthesis...
May 1, 2018: GeroScience
https://www.readbyqxmd.com/read/29712956/parallel-evolution-of-vgsc-mutations-at-domains-is6-iis6-and-iiis6-in-pyrethroid-resistant-aedes-aegypti-from-mexico
#9
Karla Saavedra-Rodriguez, Farah Vera Maloof, Corey L Campbell, Julian Garcia-Rejon, Audrey Lenhart, Patricia Penilla, Americo Rodriguez, Arturo Acero Sandoval, Adriana E Flores, Gustavo Ponce, Saul Lozano, William C Black
Aedes aegypti is the primary urban mosquito vector of viruses causing dengue, Zika and chikungunya fevers -for which vaccines and effective pharmaceuticals are still lacking. Current strategies to suppress arbovirus outbreaks include removal of larval-breeding sites and insecticide treatment of larval and adult populations. Insecticidal control of Ae. aegypti is challenging, due to a recent rapid global increase in knockdown-resistance (kdr) to pyrethroid insecticides. Widespread, heavy use of pyrethroid space-sprays has created an immense selection pressure for kdr, which is primarily under the control of the voltage-gated sodium channel gene (vgsc)...
April 30, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29702046/are-excipients-inert-phenytoin-pharmaceutical-investigations-with-new-incompatibility-insights
#10
Daniela Amaral Silva, Raimar Löbenberg, Neal Davies
PURPOSE: The U.S. Pharmacopeia defines excipients as substances other than the active pharmaceutic ingredient (API) that are added in a drug delivery system in order to aid in the manufacturing process and enhance stability, bioavailability, safety, effectiveness and delivery of the drug. The 1968 phenytoin intoxication outbreak in Brisbane, Australia, is a classic example of an API-excipient interaction. When administered with CaSO4 the absorption of phenytoin was reduced due to an interaction between the API and the excipient...
2018: Journal of Pharmacy & Pharmaceutical Sciences: a Publication of the Canadian Society for Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29701454/comparative-analysis-of-aqueous-binders-for-high-energy-li-rich-nmc-as-lithium-ion-cathode-and-the-impact-of-adding-phosphoric-acid
#11
Arefeh Kazzazi, Dominic Bresser, Agnese Birrozzi, Jan von Zamory, Maral Hekmatfar, Stefano Passerini
Even though electrochemically inactive, the binding agent in lithium-ion electrodes contributes substantially to performance metrics like the achievable capacity, rate capability, and cycling stability. Herein, we present an in-depth comparative analysis of three different aqueous binding agents, allowing for the replacement of the toxic N-methyl-2-pyrrolidone (NMP) as processing solvent, for high-energy Li1.2Ni0.16Mn0.56Co0.08O2 (Li-rich NMC or LR-NMC) as potential next generation cathode material. The impact of the binding agents, sodium carboxymethyl cellulose (CMC), sodium alginate (ALG), and commercial TRD202A (TRD), and the related chemical reactions occurring during the electrode coating process on the electrode morphology and cycling performance is investigated...
April 27, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29700220/intensive-care-management-of-severe-hypernatraemia-in-the-context-of-group-a-streptococcal-septicaemia
#12
Bethan Davies, Robert Jesty, Shahana Uddin, Victoria Metaxa
This case describes a 54-year-old woman with exudative eczema, who was admitted to the intensive care unit with a serum sodium concentration of 191 mmol/L, secondary to profound dehydration in the context of group A streptococcal septicaemia. Successful rehydration and electrolyte normalisation was achieved with continuous venovenous haemodiafiltration (CVVHDF), the replacement fluid of which was infused with hypertonic saline to limit the rate of sodium reduction. This case report comments on three areas of interest...
April 26, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29691065/clinical-assessment-and-treatment-of-diabetes-in-patients-with-chronic-kidney-disease
#13
J Carretero Gómez, J C Arévalo Lorido
Diabetes mellitus type 2 is the main cause of chronic kidney disease. Patients with this disease have higher morbidity and mortality and risk of hypoglycaemia than those without this disease. In 2010, type 2 diabetes was the reason for starting renal replacement therapy in 24.7% of patients. The prevalence of microalbuminuria, proteinuria and a reduced glomerular filtration rate is 36%, 8% and 22%, respectively. The presence of albuminuria is a predictor of chronic kidney disease. Diabetic kidney disease, previously known as diabetic nephropathy, refers to kidney disease caused by diabetes...
April 21, 2018: Revista Clínica Española
https://www.readbyqxmd.com/read/29686617/a-chimeric-nav1-8-channel-expression-system-based-on-hek293t-cell-line
#14
Xi Zhou, Yunxiao Zhang, Dongfang Tang, Songping Liang, Ping Chen, Cheng Tang, Zhonghua Liu
Among the nine voltage-gated sodium channel (NaV) subtypes, NaV1.8 is an attractive therapeutic target for pain. The heterologous expression of recombinant NaV1.8 currents is of particular importance for its electrophysiological and pharmacological studies. However, NaV1.8 expresses no or low-level functional currents when transiently transfected into non-neuronal cell lines. The present study aims to explore the molecular determinants limiting its functional expression and accordingly establish a functional NaV1...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29677537/the-rescue-effect-of-mesenchymal-stem-cell-on-sodium-iodate-induced-retinal-pigment-epithelial-cell-death-through-deactivation-of-nf-%C3%AE%C2%BAb-mediated-nlrp3-inflammasome
#15
Xiying Mao, Ting Pan, Han Shen, Huiyu Xi, Songtao Yuan, Qinghuai Liu
Age-related macular degeneration (AMD) is a multifactorial disease resulting in the gradual loss of retinal pigment epithelium (RPE) and the permanent visual damage. Various risk factors, including oxidative stress, form a complex network at the confluence of inflammation. Mesenchymal stem cell (MSC) is a well-studied population of adult stem cell with strong neuroprotective and immunoregulatory properties. Here, we reported the protective effect of MSC on sodium iodate (NaIO3)-triggered RPE degeneration. Sodium iodate (NaIO3)-induced RPE cell death was remarkably reduced when cocultured with MSC...
April 17, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29670350/colloidal-plasmonic-gold-nanoparticles-and-gold-nanorings-shape-dependent-generation-of-singlet-oxygen-and-their-performance-in-enhanced-photodynamic-cancer-therapy
#16
Yamin Yang, Yue Hu, Henry Du, Lei Ren, Hongjun Wang
Introduction: In recognition of the potentials of gold nanoparticles (Au NPs) in enhanced photodynamic therapy (PDT) for cancer, it is desirable to further understand the shape-dependent surface plasmonic resonance (SPR) properties of various gold nanostructures and evaluate their performances in PDT. Materials and methods: Monodispersed colloidal spherical solid Au NPs were synthesized by UV-assisted reduction using chloroauric acid and sodium citrate, and hollow gold nanorings (Au NRs) with similar outer diameter were synthesized based on sacrificial galvanic replacement method...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29668358/impact-of-sodium-ion-on-multivalent-metal-ion-content-in-extracellular-polymeric-substances-of-granular-sludge-from-an-expanded-granular-sludge-bed
#17
Peixiang Fang, Xinlin He, Junfeng Li, Guang Yang, Zhaoyang Wang, Zhihua Sun, Xuan Zhang, Chun Zhao
The long-term and short-term effects of salinity on the multivalent metal ions within extracellular polymeric substance (EPS) were investigated in this study. The results indicated that the Na+ content within the EPS increased significantly from 19.53% to 60.86% under high salinity, and this content in the saline system was 2.2 times higher than that of the control system at the end of the operation. The K+ , Ca2+ and Mg2+ contents within the EPS decreased from 33.85%, 39.19% and 5.54% to 7.07%, 25.64% and 3...
April 18, 2018: Environmental Technology
https://www.readbyqxmd.com/read/29667165/ion-mobility-measurements-of-multianionic-metalloporphyrin-dimers-structural-changes-induced-by-countercation-exchange
#18
Erik Schneider, Katrina Brendle, Patrick Jäger, Patrick Weis, Manfred M Kappes
We present gas-phase structures of dimers of MnIII and FeIII meso-tetra(4-sulfonatophenyl)porphyrin multianions with various amounts of sodium and hydrogen counterions. The structural assignments are achieved by combining mass spectrometry, ion mobility measurements, quantum chemical calculations, and trajectory method collision cross section calculations. For a common charge state, we observe significant topological variations in the dimer structures of [(MTPPS)2 +nX](6-n)- (M=MnIII , FeIII ; X=H, Na; n = 1-3) induced by replacing hydrogen counterions by sodium...
April 17, 2018: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/29666549/reinforced-cassava-starch-based-edible-film-incorporated-with-essential-oil-and-sodium-bentonite-nanoclay-as-food-packaging-material
#19
Butsadee Iamareerat, Manisha Singh, Muhammad Bilal Sadiq, Anil Kumar Anal
Biodegradable packaging in food materials is a green technology based novel approach to replace the synthetic and conventional packaging systems. This study is aimed to formulate the biodegradable cassava starch based films incorporated with cinnamon essential oil and sodium bentonite clay nanoparticles. The films were characterized for their application as a packaging material for meatballs. The cassava starch films incorporated with sodium bentonite and cinnamon oil showed significant antibacterial potential against all test bacteria; Escherichia coli , Salmonella typhimurium and Staphylococcus aureus...
May 2018: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/29662049/acute-lymphoblastic-leukemia-presenting-with-liver-infiltration-and-severe-lactic-acidosis
#20
Ayman Hassan Sayyed, Aamer Aleem, Mohammad Sami Al-Katari, Fatma Algahtani, Khaldoon Aljerian, Talha A Aleem, Khalid Alsaleh
BACKGROUND Type-B lactic acidosis is a rare complication of solid tumors and hematological malignancies. It occurs secondary to Warburg effect, when glucose metabolism in cancer cells switches from the oxidative pathway to the glycolytic pathway. Malignant lactic acidosis is a life-threatening condition if not promptly diagnosed and treated urgently. CASE REPORT We report the case of a 58-year-old male patient who presented with severe chest pain, dyspnea, systemic symptoms, leukopenia, normocytic anemia, and severe lactic acidosis...
April 17, 2018: American Journal of Case Reports
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