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https://www.readbyqxmd.com/read/29783254/-legal-bases-of-vaccination-in-ukraine
#1
Olena O Terzi
OBJECTIVE: Introduction: Despite the extraordinary progress made in the field of vaccination, a large number of children in the last decade, 24 million children, or nearly 20% of children born every year, do not receive a full plan for vaccination during their first year of life. The aim: The purpose of the article is to analyze the legal framework of vaccination in Ukraine, comparing the approach of the domestic legislator to the vaccination with foreign experience. PATIENTS AND METHODS: Materials and methods: Methods of research are selected based on the goal of the study...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29783253/planning-of-effective-evaluation-of-the-activities-of-hospital-district-at-the-example-of-poltava-region
#2
Vyacheslav M Zhdan, Valentyn M Dvornyk, Viktor P Lysak, Igor M Skrypnyk, Valeriy I Pokhylko, Iryna A Holovanova, Inna V Bielikova, Maxim V Khorosh, Ludmila M Shylkina, Mariya M Tovstiak
OBJECTIVE: Introduction: Increasing of the availability and quality of health care in rural areas is one of the priority directions of public health and regional development policy. The need for reforming of the network of secondary health care facilities is due to the fact, that they are unable to meet the needs of the population in this specialized type of medical care in the conditions of the existing structure and funding system. The aim: to analyze the existing legislation regulating the establishment and operation of hospital districts; to determine the methodology for monitoring and evaluating of the activity of the hospital district on the example of the Poltava region...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29783237/-evaluation-on-changes-in-risk-of-spasm-of-accommodation-in-pupils-due-to-implementation-of-prevention-program
#3
Maryna O Starynets, Oleksandr M Ocheredko
OBJECTIVE: Introduction: Number of children with myopia increased 3-fold while those with spasm of accommodation followed a suit by 5-fold increase over last decade to some extend due to computerization. These tidings necessitate the development and implementation of primordial prevention programs. The aim was to evaluate the changes in risk of spasm of accommodation in pupils due to implementation of prevention program. PATIENTS AND METHODS: Materials and methods: Data collection was based on dynamic panel of pupils padding by first-formers over 2012-2015 and tracing up to 2017, sample size is 1115...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29783230/comprehensive-patterns-of-comorbidity-copd-and-depression-aspects-of-treatment
#4
Natalia V Moisieieva, Liliya V Burya, Anna A Kapustianskaya, Iryna A Kolenko, Maria A Rumyantseva, Oleksii H Shumeiko
OBJECTIVE: Introduction: Data on the prevalence of psychopathological disorders in the exacerbation of chronic obstructive pulmonary disease (COPD) are very heterogeneous. COPD and depression have common predisposing factors. The aim: The aim of the research is to conduct a comprehensive assessment of the effect of paroxetine on the level of depressive disorders in the exacerbation of severe degree COPD in women. PATIENTS AND METHODS: Materials and methods: The study included patients with severe degree COPD and depressive disorder...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29783216/-complex-of-psycho-hygienic-correction-measures-of-personality-features-of-hiv-infected-men-and-evaluation-of-their-efficiency
#5
Ihor V Serheta, Oksana B Dudarenko, Olha P Mostova, Tetiana V Lobastova, Vitalii M Andriichuk, Larysa M Vakolyuk, Olha M Yakubovska
OBJECTIVE: Introduction: In addition to adequate diagnosis and treatment of HIV-infected individuals, development, scientific substantiation and implementation of psycho-hygienic measures aimed at correcting the processes of forming personality traits and improving the psycho-emotional state of HIV-infected individuals are of particular importance. The aim: The purpose of the scientific research was to determine the most significant changes of situational and personal anxiety indicators, the degree of gravity of the asthenic state and depressive manifestations that were recorded in the context of the introduction of a number of measures for psycho-hygienic correction...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29783197/quantification-of-21-antihypertensive-drugs-in-serum-using-uhplc-ms-ms
#6
Per Ole M Gundersen, Arne Helland, Olav Spigset, Solfrid Hegstad
BACKGROUND: Poor drug adherence in hypertensive patients can lead to treatment failure and increased cardiovascular morbidity, as well as increased costs to society. An analytical method based on ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MSMS) was developed and validated for use in routine therapeutic drug monitoring (TDM). The method includes 21 antihypertensive drugs or active metabolites from the groups beta blockers (n=5), calcium antagonists (n=5), angiotensin II receptor antagonists (n=4), angiotensin converting enzyme (ACE) inhibitors (n=3) and diuretics (n = 3), in addition to one α1-selective alpha blocker...
April 28, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29783186/-1-h-nmr-and-uplc-ms-metabolomics-functional-tools-for-exploring-chemotypic-variation-in-sceletium-tortuosum-from-two-provinces-in-south-africa
#7
Jianping Zhao, Ikhlas A Khan, Sandra Combrinck, Maxleene Sandasi, Weiyang Chen, Alvaro M Viljoen
Sceletium tortuosum (Aizoaceae) is widely recognised for the treatment of stress, anxiety and depression, as well as for obsessive compulsive disorders. A comprehensive intraspecies chemotypic variation study, using samples harvested from two distinct regions of South Africa, was done using both proton nuclear magnetic resonance (1 H-NMR) spectroscopy of methanol extracts (N = 145) and ultra performance liquid chromatography-mass spectrometry (UPLC-MS) of acid/base extracts (N = 289). Chemometric analysis of the 1 H-NMR data indicated two main clusters that were region-specific (Northern Cape and Western Cape provinces)...
May 17, 2018: Phytochemistry
https://www.readbyqxmd.com/read/29783181/autistic-traits-in-epilepsy-models-why-when-and-how
#8
REVIEW
Jana Velíšková, Jill L Silverman, Melissa Benson, Pierre-Pascal Lenck-Santini
Autism spectrum disorder (ASD) is a common comorbidity of epilepsy and seizures and/or epileptiform activity are observed in a significant proportion of ASD patients. Current research also implies that autistic traits can be observed to a various degree in mice and rats with seizures. This suggests that there are shared mechanisms in both ASD and epilepsy syndromes. Here, we first review the standard, validated methods used to assess autistic traits in animal models as well as their limitations with regards to epilepsy models...
May 18, 2018: Epilepsy Research
https://www.readbyqxmd.com/read/29783173/development-and-validation-of-an-analytical-method-for-regorafenib-and-its-metabolites-in-mouse-plasma
#9
Qiang Fu, Mingqing Chen, Shuiying Hu, Craig A McElroy, Ron H Mathijssen, Alex Sparreboom, Sharyn D Baker
An analytical method was developed for measuring the effect of OATP1B2 deficiency on plasma levels of the kinase inhibitor regorafenib and its metabolites regorafenib-N-oxide, N-desmethyl-regorafenib-N-oxide, and regorafenib-N-β-glucuronide (RG) in mice. Compounds were separated by liquid chromatography and monitored by a triple quadrupole mass spectrometer in the selected reaction monitoring mode after positive electrospray ionization. All calibration curves were linear in the selected concentration range (R2  ≥ 0...
May 5, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29783171/ghep-isfg-collaborative-exercise-on-mixture-profiles-ghep-mix06-reporting-conclusions-results-and-evaluation
#10
P A Barrio, M Crespillo, J A Luque, M Aler, C Baeza-Richer, L Baldassarri, E Carnevali, P Coufalova, I Flores, O García, M A García, R González, A Hernández, V Inglés, G M Luque, A Mosquera-Miguel, S Pedrosa, M L Pontes, M J Porto, Y Posada, M I Ramella, T Ribeiro, E Riego, A Sala, V G Saragoni, A Serrano, S Vannelli
One of the main goals of the Spanish and Portuguese-Speaking Group of the International Society for Forensic Genetics (GHEP-ISFG) is to promote and contribute to the development and dissemination of scientific knowledge in the field of forensic genetics. Due to this fact, GHEP-ISFG holds different working commissions that are set up to develop activities in scientific aspects of general interest. One of them, the Mixture Commission of GHEP-ISFG, has organized annually, since 2009, a collaborative exercise on analysis and interpretation of autosomal short tandem repeat (STR) mixture profiles...
May 18, 2018: Forensic Science International. Genetics
https://www.readbyqxmd.com/read/29783149/potential-of-near-infrared-spectroscopy-for-quality-evaluation-of-cattle-leather
#11
Carlos Eduardo M Braz, Manuel Antonio C Jacinto, Edenir R Pereira-Filho, Gilberto B Souza, Ana Rita A Nogueira
Models using near-infrared spectroscopy (NIRS) were constructed based on physical-mechanical tests to determine the quality of cattle leather. The following official parameters were used, considering the industry requirements: tensile strength (TS), percentage elongation (%E), tear strength (TT), and double hole tear strength (DHS). Classification models were constructed with the use of k-nearest neighbor (kNN), soft independent modeling of class analogy (SIMCA), and partial least squares-discriminant analysis (PLS-DA)...
May 9, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29783148/comparative-study-of-six-sequential-spectrophotometric-methods-for-quantification-and-separation-of-ribavirin-sofosbuvir-and-daclatasvir-an-application-on-laboratory-prepared-mixture-pharmaceutical-preparations-spiked-human-urine-spiked-human-plasma-and-dissolution
#12
Wafaa S Hassan, Manal S Elmasry, Heba M Elsayed, Dalia W Zidan
In accordance with International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH) guidelines, six novel, simple and precise sequential spectrophotometric methods were developed and validated for the simultaneous analysis of Ribavirin (RIB), Sofosbuvir (SOF), and Daclatasvir (DAC) in their mixture without prior separation steps. These drugs are described as co-administered for treatment of Hepatitis C virus (HCV). HCV is the cause of hepatitis C and some cancers such as liver cancer (hepatocellular carcinoma) and lymphomas in humans...
May 18, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29783144/analogous-modified-dna-probe-and-immune-competition-method-based-electrochemical-biosensor-for-rna-modification
#13
Tao Dai, Qinli Pu, Yongcan Guo, Chen Zuo, Shulian Bai, Yujun Yang, Dan Yin, Yi Li, Shangchun Sheng, Yiyi Tao, Jie Fang, Wen Yu, Guoming Xie
N6-methyladenosine (m6A), one of the most abundant RNA methylation which is ubiquitous in eukaryotic RNA, plays vital roles in many biological progresses. Therefore, the rapid and accurate quantitative detection of m6A is particularly important for its functional research. Herein, a label-free and highly selective electrochemical immunosensor was developed for the detection of m6A. The method is established on that the anti-m6A-Ab can recognize both m6A-RNA and m6A-DNA. An analogous modified DNA probe (L1) serves as a signal molecule, by competing with m6A-RNA for binding to Abs to broaden the linear range...
May 18, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29783139/inspection-of-baked-carbon-anodes-using-a-combination-of-multi-spectral-acousto-ultrasonic-techniques-and-principal-component-analysis
#14
Moez Ben Boubaker, Donald Picard, Carl Duchesne, Jayson Tessier, Houshang Alamdari, Mario Fafard
This paper reports on the application of an acousto-ultrasonic (AU) scheme for the inspection of industrial-size carbon anode blocks used in the production of primary aluminium by the Hall-Héroult process. A frequency-modulated wave is used to excite the anode blocks at multiple points. The collected attenuated AU signals are decomposed using the Discrete Wavelet Transform (DTW) after which vectors of features are calculated. Principal Component Analysis (PCA) is utilized to cluster the AU responses of the anodes...
May 17, 2018: Ultrasonics
https://www.readbyqxmd.com/read/29783116/modelling-environment-contamination-with-heavy-metals-in-flathead-grey-mullet-mugil-cephalus-and-upper-sediments-from-north-african-coasts-of-the-mediterranean-sea
#15
Naouel Ouali, Bourhane-Eddine Belabed, Haroun Chenchouni
Heavy metals are a serious hazard for aquatic ecosystems and human health. They negatively affect aquatic life functioning through accumulation resulting physiological/growth disturbances in aquatic lifeforms. This survey focused on the assessment of heavy metal pollution in the Gulf of Annaba (northeastern Algeria), the largest and most diversified industrial hub in Africa, using a multi-compartment approach (water-sediment-biota). The study aims to characterize the spatiotemporal variation of trace metal (TM) contamination and its effects on the growth of the Flathead grey mullet (Mugil cephalus)...
May 18, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29783058/memory-retrieval-of-everyday-information-under-stress
#16
Lisa-Marie Stock, Christian J Merz
Psychosocial stress is known to crucially influence learning and memory processes. Several studies have already shown an impairing effect of elevated cortisol concentrations on memory retrieval. These studies mainly used learning material consisting of stimuli with a limited ecological validity. When using material with a social contextual component or with educational relevant material both impairing and enhancing stress effects on memory retrieval could be observed. In line with these latter studies, the present experiment also used material with a higher ecological validity (a coherent text consisting of daily relevant numeric, figural and verbal information)...
May 18, 2018: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/29783021/a-hyper-diverse-genus-of-acanthocephalans-revealed-by-tree-based-and-non-tree-based-species-delimitation-methods-ten-cryptic-species-of-neoechinorhynchus-in-middle-american-freshwater-fishes
#17
Carlos Daniel Pinacho-Pinacho, Martín García-Varela, Ana L Sereno-Uribe, Gerardo Pérez-Ponce de León
The genus Neoechinorhynchus represents a hyper-diverse group of acanthocephalans, parasites of fresh and brackish water fish and freshwater turtles, with approximately 116 species described worldwide. Forty-nine species have been recorded in the Americas, nine of them in Middle America. Even though species delimitation methods using DNA sequences have been rarely used for parasitic helminths, the genetic library for species of Neoechinorhynchus has grown in the past few years, enhancing the possibility of using these methods for inferring evolutionary relationships and for establishing more robust species boundaries...
May 18, 2018: Molecular Phylogenetics and Evolution
https://www.readbyqxmd.com/read/29783012/decisional-conflict-among-patients-considering-treatment-options-for-lumbar-herniated-disc
#18
Hwang Richard, Lambrechts Sylvia, Liu Hui, Christopher S Saigal, Kwan Lorna, Cisneros Crystal, Langston T Holly, Duru O Kenrik
BACKGROUND: Lumbar herniated disc is a "preference-sensitive" condition, in which the optimal treatment choice is crucially dependent on an informed patient's goals and values. Little is known about decisional conflict, defined as an individual's level of uncertainty regarding a decision, in patients considering treatment for lumbar herniated discs. Our work aims to identify factors associated with decisional conflict and areas for improved shared decision-making. METHODS: We prospectively surveyed patients seeking treatment for a lumbar herniated disc at L4-L5 and/or L5-S1 with a physician at the UCLA Spine Center...
May 18, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29782997/measurement-error-and-timing-of-predictor-values-for-multivariable-risk-prediction-models-are-poorly-reported
#19
REVIEW
Rebecca Whittle, George Peat, John Belcher, Gary S Collins, Richard D Riley
OBJECTIVE: Measurement error in predictor variables may threaten the validity of clinical prediction models. We sought to evaluate the possible extent of the problem. A secondary objective was to examine whether predictors are measured at the intended moment of model use. METHODS: A systematic search of Medline was used to identify a sample of articles reporting the development of a clinical prediction model published in 2015. After screening according to a predefined inclusion criteria, information on predictors, strategies to control for measurement error and intended moment of model use were extracted...
May 18, 2018: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/29782993/generalized-recurrent-neural-network-accommodating-dynamic-causal-modeling-for-functional-mri-analysis
#20
Yuan Wang, Yao Wang, Yvonne W Lui
Dynamic Causal Modeling (DCM) is an advanced biophysical model which explicitly describes the entire process from experimental stimuli to functional magnetic resonance imaging (fMRI) signals via neural activity and cerebral hemodynamics. To conduct a DCM study, one needs to represent the experimental stimuli as a compact vector-valued function of time, which is hard in complex tasks such as book reading and natural movie watching. Deep learning provides the state-of-the-art signal representation solution, encoding complex signals into compact dense vectors while preserving the essence of the original signals...
May 18, 2018: NeuroImage
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