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https://www.readbyqxmd.com/read/28648012/-validation-of-the-caprini-risk-assessment-model-for-venous-thromboembolism-in-chinese-hospitalized-patients-in-a-general-hospital
#1
X Y Luo, F X Zhang
Objective: To assess the validity of Caprini risk assessment model in prediction of venous thromboembolism in Chinese hospitalized patients in a general hospital. Methods: Medical record review was performed in Beijing Shijitan Hosital for all eligible hospitalized patients who underwent screening for venous thromboembolism between January and December 2015. The Caprini score of patients with or without venous thromboemboilism and incidence of venous thromboembolism in patients with various Caprini risk levels, surgery and medical patients was compared...
June 27, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28647934/colorectal-and-endometrial-cancer-risk-and-age-at-diagnosis-in-blmash-mutation-carriers
#2
Hagit Schayek, Yael Laitman, Lior H Katz, Elon Pras, Liat Ries-Levavi, Frida Barak, Eitan Friedman
BACKGROUND: Biallelic BLM gene mutation carriers are at an increased risk for cancer, including colorectal cancer (CRC). Whether heterozygous BLM gene mutations confer an increased cancer risk remains controversial. OBJECTIVES: To evaluate CRC and endometrial cancer risk in BLM heterozygous mutation carriers. METHODS: Jewish Ashkenazim at high risk for colon or endometrial cancer and endometrial cancer cases unselected for family history were genotyped for the BLMAsh predominant mutation...
June 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28647909/organic-matter-export-to-the-seafloor-in-the-baltic-sea-drivers-of-change-and-future-projections
#3
Tobias Tamelander, Kristian Spilling, Monica Winder
The impact of environmental change and anthropogenic stressors on coastal marine systems will strongly depend on changes in the magnitude and composition of organic matter exported from the water column to the seafloor. Knowledge of vertical export in the Baltic Sea is synthesised to illustrate how organic matter deposition will respond to climate warming, climate-related changes in freshwater runoff, and ocean acidification. Pelagic heterotrophic processes are suggested to become more important in a future warmer climate, with negative feedbacks to organic matter deposition to the seafloor...
June 24, 2017: Ambio
https://www.readbyqxmd.com/read/28647889/viability-of-the-world-health-organization-quality-of-life-measure-to-assess-changes-in-quality-of-life-following-treatment-for-alcohol-use-disorder
#4
Megan Kirouac, Elizabeth R Stein, Matthew R Pearson, Katie Witkiewitz
PURPOSE: Quality of life is an outcome often examined in treatment research contexts such as biomedical trials, but has been studied less often in alcohol use disorder (AUD) treatment. The importance of considering QoL in substance use treatment research has recently been voiced, and measures of QoL have been administered in large AUD treatment trials. Yet, the viability of popular QoL measures has never been evaluated in AUD treatment samples. Accordingly, the present manuscript describes a psychometric examination of and prospective changes in the World Health Organization Quality of Life measure (WHOQOL-BREF) in a large sample (N = 1383) of patients with AUD recruited for the COMBINE Study...
June 24, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28647861/qualitative-spatial-logic-descriptors-from-3d-indoor-scenes-to-generate-explanations-in-natural-language
#5
Zoe Falomir, Thomas Kluth
The challenge of describing 3D real scenes is tackled in this paper using qualitative spatial descriptors. A key point to study is which qualitative descriptors to use and how these qualitative descriptors must be organized to produce a suitable cognitive explanation. In order to find answers, a survey test was carried out with human participants which openly described a scene containing some pieces of furniture. The data obtained in this survey are analysed, and taking this into account, the QSn3D computational approach was developed which uses a XBox 360 Kinect to obtain 3D data from a real indoor scene...
June 24, 2017: Cognitive Processing
https://www.readbyqxmd.com/read/28647846/attentional-processing-of-itch
#6
A I M van Laarhoven, S van Damme, A P M Lavrijsen, D M van Ryckeghem, G Crombez, A W M Evers
Itch is a prevalent somatosensory symptom that can be highly disabling, because it is likely to draw attention and, as a result, may interfere with the performance of daily activities. Yet, research experimentally investigating attention to itch is lacking. In this study we aimed to investigate attentional processing of itch using multiple behavioral attention tasks. Forty-one healthy participants performed (1) a modified Stroop task with itch-related words, (2) a dot-probe task with itch-related pictures, and (3) a recently developed somatosensory attention task in which the effect of experimentally induced itch on the localization of visual targets was examined...
June 24, 2017: Psychological Research
https://www.readbyqxmd.com/read/28647832/genetic-dissection-of-adventitious-shoot-regeneration-in-roses-by-employing-genome-wide-association-studies
#7
Thi Hong Nhung Nguyen, Dietmar Schulz, Traud Winkelmann, Thomas Debener
We analysed the capacity to regenerate adventitious shoots in 96 rose genotypes and found 88 SNP markers associated with QTLs, some of which are derived from candidate genes for shoot regeneration. In an association panel of 96 rose genotypes previously analysed for petal colour, we conducted a genome-wide association study on the capacity of leaf petioles for direct shoot regeneration. Shoot regeneration rate and shoot ratio (number of shoots/total number of explants) were used as phenotypic descriptors for regeneration capacity...
June 24, 2017: Plant Cell Reports
https://www.readbyqxmd.com/read/28647819/the-italian-version-of-the-opening-minds-stigma-scale-for-healthcare-providers-validation-and-study-on-a-sample-of-bachelor-students
#8
Anne Destrebecq, Paolo Ferrara, Luca Frattini, Francesco Pittella, Gemma Rossano, Giuseppe Striano, Stefano Terzoni, Orsola Gambini
Prejudices on psychiatric disorders frequently turn into stigmatizating attitudes, also among health care providers. The Opening Minds Stigma Scale for Health Care Providers (OMS-HC) was introduced in 2012 to measure stigma. No Italian versions of this tool exist so far. We wanted to investigate stigma among healthcare students in Italy, and to prepare an Italian version of the scale. A multicentric, cross-sectional study was conducted on a sample of Nursing, Physiotherapy, Occupational therapy, and Dietistics students...
June 24, 2017: Community Mental Health Journal
https://www.readbyqxmd.com/read/28647743/predictive-accuracy-of-calf-circumference-measurements-to-detect-decreased-skeletal-muscle-mass-and-european-society-for-clinical-nutrition-and-metabolism-defined-malnutrition-in-hospitalized-older-patients
#9
Keisuke Maeda, Takayuki Koga, Tomomi Nasu, Miki Takaki, Junji Akagi
BACKGROUND/AIMS: The ability to readily diagnose sarcopenia and malnutrition in a clinical setting is essential. This study is aimed at clarifying the calf circumference (CC) cut-off values for decreased skeletal muscle mass (SMM), according to the Asian Work Group for Sarcopenia's criteria definition of sarcopenia, and those for European Society for Clinical Nutrition and Metabolism-defined malnutrition, in hospitalized Japanese patients. METHODS: The study involved 1,164 patients aged ≥65 years...
June 24, 2017: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/28647719/a-cross-sectional-study-on-the-prevalence-and-associated-risk-factors-for-workplace-violence-against-chinese-nurses
#10
Lei Shi, Danyang Zhang, Chenyu Zhou, Libin Yang, Tao Sun, Tianjun Hao, Xiangwen Peng, Lei Gao, Wenhui Liu, Yi Mu, Yuzhen Han, Lihua Fan
OBJECTIVES: The purpose of the present study was to explore the characteristics of workplace violence that Chinese nurses at tertiary and county-level hospitals encountered in the 12 months from December 2014 to January 2016, to identify and analyse risk factors for workplace violence, and to establish the basis for future preventive strategies. DESIGN: A cross-sectional study. SETTING: A total of 44 tertiary hospitals and 90 county-level hospitals in 16 provinces (municipalities or autonomous regions) in China...
June 24, 2017: BMJ Open
https://www.readbyqxmd.com/read/28647700/molecular-proteomic-characterization-of-a-pediatric-medulloblastoma-xenograft
#11
George T Tsangaris, Konstantinos Dimas, Angeliki Malamou, Angeliki Katsafadou, Chrissa Papathanasiou, Dimitrios J Stravopodis, Constantinos E Vorgias, Maria Gazouli, Athanasios K Anagnostopoulos
BACKGROUND/AIM: Medulloblastoma (MBL), an archetypal primitive neuroectodermal tumor of the cerebellum, is the most common pediatric central nervous system malignancy representing approximately 20% of all childhood brain tumors. Herein, we report on a new xenotransplantable tumor cell line, derived from a 6-year-old female patient with cerebellar medulloblastoma, and the completele proteome molecular characterization of subsequent tumors from MBL xenotrasplanted mice. MATERIALS AND METHODS: Tumors were grown in nude mice as subcutaneous xenografts (MBLX) composed of small round cells with hyperchromatic nuclei and scant cytoplasm...
July 2017: Cancer Genomics & Proteomics
https://www.readbyqxmd.com/read/28647699/proteomic-analysis-of-normal-and-cancer-cervical-cell-lines-reveals-deregulation-of-cytoskeleton-associated-proteins
#12
Kalliopi I Pappa, Vasiliki Lygirou, Georgia Kontostathi, Jerome Zoidakis, Manousos Makridakis, Konstantinos Vougas, George Daskalakis, Alexander Polyzos, Nicholas P Anagnou
BACKGROUND: Both HPV-positive and -negative cervical cancers are primarily associated with features of cell cycle and cytoskeletal disruption; however, the actual biological processes affected remain elusive. To this end, we systematically characterized the intracellular proteomic profiles of four distinct and informative cervical cell lines. MATERIALS AND METHODS: Cell extracts from a normal cervical (HCK1T) and three cervical cancer cell lines, one HPV-negative (C33A), and two HPV-positive, SiHa (HPV16+) and HeLa (HPV18+), were analyzed by 2-dimensional electrophoresis and differentially expressed proteins were identified by MALDI-TOF mass spectrometry, while differential expression was confirmed by western blot analysis...
July 2017: Cancer Genomics & Proteomics
https://www.readbyqxmd.com/read/28647661/can-we-make-still-easier-simple-in-situ-decompression-of-the-ulnar-nerve-at-the-elbow
#13
Vicente Vanaclocha, Trinidad Blanco, Pedro Ortiz, Javier López-Trigo, Vicente Bordes, Pau Capilla, Leyre Vanaclocha
BACKGROUND: in situ decompression and transposition are equally effective in cubital tunnel syndrome treatment. Both are traditionally performed in the supine position. AIM: to validate our surgical to present our technique for in situ decompression in lateral decubitus position, comparing results with other techniques used in our Institutions. METHODS: Retrospective study. Period January 2009-February 2016. 188 cubital tunnel syndrome patients, 115 males, 73 females, age mean 53...
June 21, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28647655/face-content-and-construct-validity-of-an-aneurysm-clipping-model-using-human-placenta
#14
Evgenii Belykh, Eric J Miller, Ting Lei, Kristina Chapple, Vadim A Byvaltsev, Robert F Spetzler, Peter Nakaji, Mark C Preul
OBJECTIVE: Proficient open surgical treatment of cerebral aneurysms requires extensive training and practice. The goal of this study was to test the validity of a human placenta aneurysm model for surgical simulation training of aneurysm clipping. METHODS: Thirty participants were divided into 3 groups (n=10 per group) according to their neurosurgical experience: low experience, intermediate experience, and attending. Subjective measures were collected using the Aneurysm Clipping Participant Survey (n=27)...
June 21, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28647652/kinase-activity-in-recurring-primary-skull-base-chordomas-and-chondrosarcomas-identification-of-novel-pathways-of-oncogenesis-and-potential-drug-targets
#15
Philip Tatman, Joshua Osbun, Youssef Yakkioui, Sumanpret Kaur, Carolina Parada, Tina Busald, Donald Born, Owais Ahmad, Jing Zhang, Manuel Ferreira
OBJECTIVE: Chordomas and chondrosarcomas are tumors that can occur in the skull base. Currently, 45% of chordomas and 56% of chondrosarcomas recur within five years of surgery. The role of adjuvant therapy is highly debated. No pharmacotherapies have been approved by the FDA for chordomas or chondrosarcomas. The high propensity for recurrence and lack of definitive adjuvant therapy necessitates additional basic science research to identify molecular anomalies associated with recurrent disease...
June 21, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28647650/quick-sequential-organ-failure-assessment-compared-to-systemic-inflammatory-response-syndrome-for-predicting-sepsis-in-emergency-department
#16
Hyun Kyung Park, Won Young Kim, Myung Chun Kim, Woong Jung, Byuk Sung Ko
PURPOSE: It is unclear whether quick sequential (sepsis-related) organ failure assessment (qSOFA) also has prognostic value for organ failure in patients with a suspected infection. The aim of this study was to determine whether qSOFA has prognostic value when compared to systemic inflammatory response syndrome (SIRS) in predicting organ failure in patients with a suspected infection in an emergency department (ED). METHODS: A retrospective observational study was conducted in an ED during a 9-year period...
June 19, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28647647/itraq-based-quantitative-analysis-of-alveolar-bone-resorption-in-rats-with-experimental-periodontitis
#17
Weidong Yang, Yafan Gao, Yajie Qian, Jingjing Li, Qingang Hu
OBJECTIVE: Periapical periodontitis results in alveolar bone resorption around the root apex. During the progression of inflammation, host cells release various inflammatory mediators and pro-inflammatory cytokines through immune responses. However, the pathological mechanisms associated with periapical bone destruction remain unclear. This study was objected to identify differentially regulated proteins in periapical periodontitis via a quantitative proteomics approach using isobaric tags for relative and absolute quantification (iTRAQ) labelling of peptides...
June 13, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28647613/validating-a-two-dimensional-bipolar-spectrum-model-integrating-dsm-5-s-mixed-features-specifier-for-major-depressive-disorder
#18
Panagiotis Ferentinos, Konstantinos N Fountoulakis, Cathryn M Lewis, Evgenia Porichi, Dimitris Dikeos, Charalambos Papageorgiou, Athanassios Douzenis
INTRODUCTION: The literature on DSM-5's 'Major Depressive Disorder with lifetime mixed features' (MDD-MF) is limited. This study investigated MDD-MF's potential inclusion into a bipolar spectrum. METHODS: We recruited 287 patients with Bipolar I disorder (BD-I), BD-II, MDD-MF or 'MDD without lifetime mixed features' (MDD-noMF); most (N=280) were stabilized for at least one year on medication. Sixteen validators (clinical features, psychiatric family history, temperament, stabilizing treatment) were compared across groups and subjected to trend analyses...
June 16, 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/28647567/stearoyl-coa-desaturase-regulates-sorafenib-resistance-via-modulation-of-er-stress-induced-differentiation
#19
Mark Kin Fai Ma, Eunice Yuen Ting Lau, Doris Hoi Wing Leung, Jessica Lo, Nicole Pui Yu Ho, Lily Kwan Wai Cheng, Stephanie Ma, Chi Ho Lin, John A Copland, Jin Ding, Regina Cheuk Lam Lo, Irene Oi Lin Ng, Terence Kin Wah Lee
We investigated the functional role and clinical significance of Stearoyl CoA desaturase-1 (SCD1) mediated endoplasmic reticulum (ER) stress in regulation of liver tumor-initiating cells (T-ICs) and sorafenib resistance, aiming to develop a novel therapeutic strategy against hepatocellular carcinomas (HCCs) METHODS We evaluated the clinic-pathological relevance of SCD1 and its correlation with sorafenib resistance in large cohorts of HCC clinical samples by qPCR and immunohistochemical analyses. Lentiviral-based overexpression and knockdown approaches were performed to characterize functional roles of SCD1 in regulation of liver T-ICs and sorafenib resistance...
June 21, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28647565/review-of-the-cytology-and-connections-of-the-lateral-habenula-an-avatar-of-adaptive-behaving
#20
REVIEW
Daniel S Zahm, David H Root
The cytology and connections of the lateral habenula (LHb) are reviewed. The habenula is first introduced, after which the cytology of the LHb is discussed mainly with reference to cell types, general topography and descriptions of subnuclei. An overview of LHb afferent connections is given followed by some details about the projections to LHb from a number of structures. An overview of lateral habenula efferent connections is given followed by some details about the projections from LHb to a number of structures...
June 21, 2017: Pharmacology, Biochemistry, and Behavior
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