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https://www.readbyqxmd.com/read/29141396/proposal-of-a-pretreatment-nomogram-for-predicting-local-recurrence-after-intensity-modulated-radiation-therapy-in-t4-nasopharyngeal-carcinoma-a-retrospective-review-of-415-chinese-patients
#1
Lu-Lu Zhang, Yi-Yang Li, Jiang Hu, Guan-Qun Zhou, Lei Chen, Wen-Fei Li, Ai-Hua Lin, Jun Ma, Zhen-Yu Qi, Ying Sun
Purpose: Local relapse-free survival (LRFS) differs widely among patients with T4 category nasopharyngeal carcinoma (NPC). We aimed to build a nomogram incorporating clinicopathological information to predict LRFS in T4 NPC after definitive intensity-modulated radiation therapy (IMRT). Methods and Materials: Retrospective study of 415 Chinese patients with non-metastatic T4 NPC treated with definitive IMRT with or without chemotherapy at our cancer center between October 2009 and September 2013...
November 15, 2017: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/29141332/-reliability-and-validity-of-driving-anger-scale-in-professional-drivers-in-china
#2
Z Li, Y M Yang, C Zhang, Y Li, J Hu, L W Gao, Y X Zhou, X J Zhang
Objective: To assess the reliability and validity of the Chinese version of Driving Anger Scale (DAS) in professional drivers in China and provide a scientific basis for the application of the scale in drivers in China. Methods: Professional drivers, including taxi drivers, bus drivers, truck drivers and school bus drivers, were selected to complete the questionnaire. Cronbach's α and split-half reliability were calculated to evaluate the reliability of DAS, and content, contract, discriminant and convergent validity were performed to measure the validity of the scale...
November 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/29141230/sub-minute-phosphoregulation-of-cell-cycle-systems-during-plasmodium-gamete-formation
#3
Brandon M Invergo, Mathieu Brochet, Lu Yu, Jyoti Choudhary, Pedro Beltrao, Oliver Billker
The transmission of malaria parasites to mosquitoes relies on the rapid induction of sexual reproduction upon their ingestion into a blood meal. Haploid female and male gametocytes become activated and emerge from their host cells, and the males enter the cell cycle to produce eight microgametes. The synchronized nature of gametogenesis allowed us to investigate phosphorylation signaling during its first minute in Plasmodium berghei via a high-resolution time course of the phosphoproteome. This revealed an unexpectedly broad response, with proteins related to distinct cell cycle events undergoing simultaneous phosphoregulation...
November 14, 2017: Cell Reports
https://www.readbyqxmd.com/read/29141195/determination-of-the-effect-of-pinellia-ternata-thunb-breit-on-nervous-system-development-by-proteomics
#4
Jian-Ya Xu, Chen Dai, Jin-Jun Shan, Tong Xie, Hui-Hui Xie, Ming-Ming Wang, Guang Yang
ETHNOPHARMACOLOGICAL RELEVANCE: Banxia (BX) is the dried tuber of Pinellia ternata (Thunb.) Breit., a commonly prescribed Chinese medicinal herb for the treatment of cough, phlegm, and vomiting in pregnant women. However, raw BX has been demonstrated to exert toxic effects on reproduction and the precise and comprehensive mechanisms remain elusive. AIM OF THE STUDY: We applied an iTRAQ (isobaric tags for relative and absolute quantitation, iTRAQ)-based proteomic method to explore the mechanisms of raw BX-induced fetal toxicity in mice...
November 12, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29141153/using-observational-data-to-calibrate-simulation-models
#5
Eleanor J Murray, James M Robins, George R Seage, Sara Lodi, Emily P Hyle, Krishna P Reddy, Kenneth A Freedberg, Miguel A Hernán
BACKGROUND: Individual-level simulation models are valuable tools for comparing the impact of clinical or public health interventions on population health and cost outcomes over time. However, a key challenge is ensuring that outcome estimates correctly reflect real-world impacts. Calibration to targets obtained from randomized trials may be insufficient if trials do not exist for populations, time periods, or interventions of interest. Observational data can provide a wider range of calibration targets but requires methods to adjust for treatment-confounder feedback...
November 1, 2017: Medical Decision Making: An International Journal of the Society for Medical Decision Making
https://www.readbyqxmd.com/read/29141096/quantifying-publication-bias-in-meta-analysis
#6
Lifeng Lin, Haitao Chu
Publication bias is a serious problem in systematic reviews and meta-analyses, which can affect the validity and generalization of conclusions. Currently, approaches to dealing with publication bias can be distinguished into two classes: selection models and funnel-plot-based methods. Selection models use weight functions to adjust the overall effect size estimate and are usually employed as sensitivity analyses to assess the potential impact of publication bias. Funnel-plot-based methods include visual examination of a funnel plot, regression and rank tests, and the nonparametric trim and fill method...
November 15, 2017: Biometrics
https://www.readbyqxmd.com/read/29141084/association-of-obsessive-compulsive-disorder-with-objective-indicators-of-educational-attainment-a-nationwide-register-based-sibling-control-study
#7
Ana Pérez-Vigil, Lorena Fernández de la Cruz, Gustaf Brander, Kayoko Isomura, Andreas Jangmo, Inna Feldman, Eva Hesselmark, Eva Serlachius, Luisa Lázaro, Christian Rück, Ralf Kuja-Halkola, Brian M D'Onofrio, Henrik Larsson, David Mataix-Cols
Importance: To our knowledge, the association of obsessive-compulsive disorder (OCD) and academic performance has not been objectively quantified. Objective: To investigate the association of OCD with objectively measured educational outcomes in a nationwide cohort, adjusting for covariates and unmeasured factors shared between siblings. Design, Setting, And Participants: This population-based birth cohort study included 2 115 554 individuals who were born in Sweden between January 1, 1976, and December 31, 1998, and followed up through December 31, 2013...
November 15, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/29141043/lateral-migration-of-electrospun-hydrogel-nanofilaments-in-an-oscillatory-flow
#8
Sylwia Pawłowska, Paweł Nakielski, Filippo Pierini, Izabela K Piechocka, Krzysztof Zembrzycki, Tomasz A Kowalewski
The recent progress in bioengineering has created great interest in the dynamics and manipulation of long, deformable macromolecules interacting with fluid flow. We report experimental data on the cross-flow migration, bending, and buckling of extremely deformable hydrogel nanofilaments conveyed by an oscillatory flow into a microchannel. The changes in migration velocity and filament orientation are related to the flow velocity and the filament's initial position, deformation, and length. The observed migration dynamics of hydrogel filaments qualitatively confirms the validity of the previously developed worm-like bead-chain hydrodynamic model...
2017: PloS One
https://www.readbyqxmd.com/read/29141042/a-tissue-microrna-signature-that-predicts-the-prognosis-of-breast-cancer-in-young-women
#9
Ai Hironaka-Mitsuhashi, Juntaro Matsuzaki, Ryou-U Takahashi, Masayuki Yoshida, Yutaka Nezu, Yusuke Yamamoto, Sho Shiino, Takayuki Kinoshita, Toshikazu Ushijima, Nobuyoshi Hiraoka, Chikako Shimizu, Kenji Tamura, Takahiro Ochiya
Since breast cancers in young women are generally aggressive, young patients tend to be intensively treated with anti-cancer drugs. To optimize the strategy for treatment, particularly in young women, prognostic biomarkers are urgently required. The objective of this study was to identify a tissue microRNA (miRNA) signature that predicts prognosis in young breast cancer patients. Total RNA from 45 breast cancer patients aged <35 years was extracted from formalin-fixed paraffin-embedded (FFPE) tissues and analyzed using miRNA microarrays...
2017: PloS One
https://www.readbyqxmd.com/read/29141033/transcriptome-profiling-of-claw-muscle-of-the-mud-crab-scylla-paramamosain-at-different-fattening-stages
#10
Qingling Jiang, Chenchang Bao, Ya'nan Yang, An Liu, Fang Liu, Huiyang Huang, Haihui Ye
In crustaceans, muscle growth and development is complicated, and to date substantial knowledge gaps exist. In this study, the claw muscle, hepatopancreas and nervous tissue of the mud crab (Scylla paramamosain) were collected at three fattening stages for sequence by the Illumina sequencing. A total of 127.87 Gb clean data with no less than 3.94 Gb generated for each sample and the cycleQ30 percentages were more than 86.13% for all samples. De Bruijn assembly of these clean data produced 94,853 unigenes, thereinto, 50,059 unigenes were found in claw muscle...
2017: PloS One
https://www.readbyqxmd.com/read/29141028/developing-methods-for-assessing-abundance-and-distribution-of-european-oysters-ostrea-edulis-using-towed-video
#11
Linnea Thorngren, Thomas Dunér Holthuis, Susanne Lindegarth, Mats Lindegarth
Due to large-scale habitat losses and increasing pressures, benthic habitats in general, and perhaps oyster beds in particular, are commonly in decline and severely threatened on regional and global scales. Appropriate and cost-efficient methods for mapping and monitoring of the distribution, abundance and quality of remaining oyster populations are fundamental for sustainable management and conservation of these habitats and their associated values. Towed video has emerged as a promising method for surveying benthic communities in a both non-destructive and cost-efficient way...
2017: PloS One
https://www.readbyqxmd.com/read/29141004/lack-of-mitochondrial-muts-homolog-1-in-toxoplasma-gondii-disrupts-maintenance-and-fidelity-of-mitochondrial-dna-and-reveals-metabolic-plasticity
#12
Tamila Garbuz, Gustavo Arrizabalaga
The importance of maintaining the fidelity of the mitochondrial genome is underscored by the presence of various repair pathways within this organelle. Presumably, the repair of mitochondrial DNA would be of particular importance in organisms that possess only a single mitochondrion, like the human pathogens Plasmodium falciparum and Toxoplasma gondii. Understanding the machinery that maintains mitochondrial DNA in these parasites is of particular relevance, as mitochondrial function is a validated and effective target for anti-parasitic drugs...
2017: PloS One
https://www.readbyqxmd.com/read/29140996/childhood-tuberculosis-is-associated-with-decreased-abundance-of-t-cell-gene-transcripts-and-impaired-t-cell-function
#13
Cheryl Hemingway, Maurice Berk, Suzanne T Anderson, Victoria J Wright, Shea Hamilton, Hariklia Eleftherohorinou, Myrsini Kaforou, Greg M Goldgof, Katy Hickman, Beate Kampmann, Johan Schoeman, Brian Eley, David Beatty, Sandra Pienaar, Mark P Nicol, Michael J Griffiths, Simon J Waddell, Sandra M Newton, Lachlan J Coin, David A Relman, Giovanni Montana, Michael Levin
The WHO estimates around a million children contract tuberculosis (TB) annually with over 80 000 deaths from dissemination of infection outside of the lungs. The insidious onset and association with skin test anergy suggests failure of the immune system to both recognise and respond to infection. To understand the immune mechanisms, we studied genome-wide whole blood RNA expression in children with TB meningitis (TBM). Findings were validated in a second cohort of children with TBM and pulmonary TB (PTB), and functional T-cell responses studied in a third cohort of children with TBM, other extrapulmonary TB (EPTB) and PTB...
2017: PloS One
https://www.readbyqxmd.com/read/29140994/copy-number-gains-at-chr3p25-and-chr11p11-are-associated-with-lymph-node-involvement-and-survival-in-muscle-invasive-bladder-tumors
#14
Karla J Lindquist, Thomas Sanford, Terence W Friedlander, Pamela L Paris, Sima P Porten
Patients with muscle-invasive bladder cancer (MIBC) have poorer prognoses if cancer has metastasized to the lymph nodes. Genomic markers of lymph node involvement (LNI) would be useful for treatment planning, especially if measured at the biopsy stage, but large-scale studies of tumor tissue at any stage are needed to discover robust markers of LNI. We performed a genome-wide query of copy number alterations (CNA) in 237 MIBC surgical tumor specimens from patients in The Cancer Genome Atlas who had radical cystectomy and lymphadenectomy without neoadjuvant treatment...
2017: PloS One
https://www.readbyqxmd.com/read/29140989/joint-approach-based-on-clinical-and-imaging-features-to-distinguish-non-neoplastic-from-neoplastic-pituitary-stalk-lesions
#15
Ji Ye Lee, Ji Eun Park, Woo Hyun Shim, Seung Chai Jung, Choong Gon Choi, Sang Joon Kim, Jeong Hoon Kim, Ho Sung Kim
PURPOSE: Distinguishing non-neoplastic pituitary stalk lesions (non-NPSLs) from neoplastic pituitary stalk lesions (NPSLs) is a major concern in guiding treatment for a thickened pituitary stalk. Our study aimed to aid provide preoperative diagnostic assistance by combining clinical and magnetic resonance imaging (MRI) findings to distinguish non-NPSLs from NPSLs. MATERIALS AND METHODS: We recruited 158 patients with thickened pituitary stalk lesions visible on MRI...
2017: PloS One
https://www.readbyqxmd.com/read/29140972/long-noncoding-rna-profiling-revealed-differentially-expressed-lncrnas-associated-with-disease-activity-in-pbmcs-from-patients-with-rheumatoid-arthritis
#16
Min Yuan, Shujun Wang, Lijie Yu, Bo Qu, Liming Xu, Lining Liu, Huanxia Sun, Chunxian Li, Yanjun Shi, Huaxiang Liu
Long noncoding RNAs (lncRNAs) have recently emerged as important biological regulators, and the aberrant expression of lncRNAs has been reported in numerous diseases. However, the expression of lncRNAs in peripheral blood mononuclear cells (PBMCs) in rheumatoid arthritis (RA) has not been well documented. We applied a microarray analysis to profile the lncRNA and mRNA expression in 3 pairs of samples. Each sample was mixed with equivalent PBMCs from 9 female RA patients and 9 corresponding healthy controls, and the data were validated via qPCR using another cohort that comprised 36 RA patients and 24 healthy controls...
2017: PloS One
https://www.readbyqxmd.com/read/29140949/predictive-ability-and-interobserver-reliability-of-computed-tomography-findings-for-angioembolization-in-patients-with-pelvic-fracture
#17
Shunsuke Yoshikawa, Atsushi Shiraishi, Mitsuhiro Kishino, Makiko Honda, Nao Urushibata, Kosuke Sekiya, Tomohisa Shoko, Yasuhiro Otomo
BACKGROUND: The purpose of this study was to identify computed tomography (CT) findings that predict the need for angioembolization in patients with pelvic fracture. METHODS: This retrospective cross-sectional study was performed between April 2006 and October 2015 at two urban emergency medical centers in Japan. The study included patients who underwent CT within 3 hours of arrival and were diagnosed with a pelvic fracture. The study outcome was undergoing angioembolization within 24 hours of arrival...
November 14, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29140943/antibodies-toward-vedolizumab-appear-from-the-first-infusion-onward-and-disappear-over-time
#18
Sumin Bian, Erwin Dreesen, Ho Tsun Tang, Griet Compernolle, Miet Peeters, Gert Van Assche, Marc Ferrante, Séverine Vermeire, Ann Gils
BACKGROUND: Vedolizumab (VDZ) has been approved for the treatment of patients with moderate-to-severe Crohn's disease and ulcerative colitis. The GEMINI trials reported a low prevalence of anti-VDZ antibodies (AVA). However, the AVA assays used in GEMINI were drug sensitive, resulting in a possible underestimation of the rate of AVA formation. This study aimed to monitor immunogenicity of VDZ in a real-life cohort using a drug-resistant AVA assay. METHODS: Using a combination of VDZ/AVA complex precipitation and acid dissociation, a drug-resistant assay for AVA detection in the presence of high VDZ concentrations has been developed and analytically validated...
December 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29140898/a-construct-validation-study-of-playfun
#19
John Cairney, Scott Veldhuizen, Jeffrey D Graham, Christine Rodriguez, Chloe Bedard, Emily Bremer, Dean Kriellaars
INTRODUCTION: PLAYfun is a measure of motor competence, comprehension and confidence which is part of a suite of scales used to assess physical literacy in children and youth. However, its measurement properties have not been reported in the published literature. The purpose of this study is to examine the factor structure of PLAYfun, in addition to variations in PLAYfun subscale results by age and sex. METHOD: In this study, we use a sample of children and youth aged 7 to 14 years (n=215) to test a proposed factor structure for the motor competence component of PLAYfun and to examine age and sex differences in subscale and total scores...
November 15, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29140887/inconsistencies-between-two-cross-cultural-adaptations-of-the-hospital-survey-on-patient-safety-culture-into-french
#20
Bastien Boussat, Patrice François, Gérald Gandon, Joris Giai, Arnaud Seigneurin, Thomas Perneger, José Labarère
OBJECTIVES: Two cross-cultural adaptations of the 12-dimension Hospital Survey on Patient Safety Culture (HSOPSC) into French coexist: the Occelli and Vlayen versions. The objective of this study was to assess the psychometric properties of the Occelli version in comparison with those reported for the Vlayen and the original US versions of this instrument. METHODS: Using the original data from a cross-sectional study of 5,064 employees at a single university hospital in France, we examined the acceptability, internal consistency, factorial structure, and construct validity of the Occelli version of the HSOPSC...
November 15, 2017: Journal of Patient Safety
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