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https://www.readbyqxmd.com/read/28527407/mechanisms-of-resistance-to-systemic-therapy-in-metastatic-castration-resistant-prostate-cancer
#1
REVIEW
Giuseppe Galletti, Benjamin I Leach, Linda Lam, Scott T Tagawa
Patients with metastatic castration-resistant prostate cancer (mCPRC) now have an unprecedented number of approved treatment options, including chemotherapies (docetaxel, cabazitaxel), androgen receptor (AR)-targeted therapies (enzalutamide, abiraterone), a radioisotope (radium-223) and a cancer vaccine (sipuleucel-T). However, the optimal treatment sequencing pathway is unknown, and this problem is exacerbated by the issues of primary and acquired resistance. This review focuses on mechanisms of resistance to AR-targeted therapies and taxane-based chemotherapy...
May 8, 2017: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/28527396/breast-oedema-following-free-flap-breast-reconstruction
#2
Jennifer Greenhowe, Christopher Stephen, Liusaidh McClymont, D Alex Munnoch
OBJECTIVES: Breast oedema causes significant morbidity and is historically difficult to quantify. The aim of this study was to identify changes in breast tissue water content from pre-operative levels in the native breast to post-operative levels in mastectomy skin flaps and free flaps in the reconstructed breast. MATERIALS AND METHODS: One hundred patients undergoing unilateral mastectomy and immediate free flap breast reconstruction were examined pre-operatively and at three post-operative appointments...
May 17, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28527393/a-combination-of-platelet-features-allows-detection-of-early-stage-cancer
#3
Siamack Sabrkhany, Marijke J E Kuijpers, Sander M J van Kuijk, Linda Sanders, Sharo Pineda, Steven W M Olde Damink, Anne-Marie C Dingemans, Arjan W Griffioen, Mirjam G A Oude Egbrink
BACKGROUND: Detection of early-stage cancer significantly improves patient survival. As platelets play an important role in cancer progression, we aimed to investigate whether platelets can be used for the discovery of early-stage cancer. METHODS: Patients with lung (n = 86) or head of pancreas (n = 42) cancer were included, as were healthy sex- and age-matched controls (n = 92). Blood was collected before initiation of treatment. Platelet count, volume and activation status were quantified in whole blood...
May 17, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28527352/a-cbr-framework-with-gradient-boosting-based-feature-selection-for-lung-cancer-subtype-classification
#4
Juan Ramos-González, Daniel López-Sánchez, Jose A Castellanos-Garzón, Juan F de Paz, Juan M Corchado
Molecular subtype classification represents a challenging field in lung cancer diagnosis. Although different methods have been proposed for biomarker selection, efficient discrimination between adenocarcinoma and squamous cell carcinoma in clinical practice presents several difficulties, especially when the latter is poorly differentiated. This is an area of growing importance, since certain treatments and other medical decisions are based on molecular and histological features. An urgent need exists for a system and a set of biomarkers that provide an accurate diagnosis...
May 13, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28527319/camera-to-subject-distance-affects-face-configuration-and-perceived-identity
#5
Eilidh Noyes, Rob Jenkins
Face identification is reliable for viewers who are familiar with the face, and unreliable for viewers who are not. One account of this contrast is that people become good at recognising a face by learning its configuration-the specific pattern of feature-to-feature measurements. In practice, these measurements differ across photos of the same face because objects appear more flat or convex depending on their distance from the camera. Here we connect this optical understanding to face configuration and identification accuracy...
May 17, 2017: Cognition
https://www.readbyqxmd.com/read/28527291/haplotypes-in-ccr5-ccr2-ccl3-and-ccl5-are-associated-with-natural-resistance-to-hiv-1-infection-in-a-colombian-cohort
#6
Jorge A Vega, Simón Villegas-Ospina, Wbeimar Aguilar-Jiménez, María T Rugeles, Gabriel Bedoya, Wildeman Zapata
INTRODUCTION: Variants in genes encoding for HIV-1 co-receptors and their natural ligands have been individually associated to natural resistance to HIV-1 infection. However, the simultaneous presence of these variants has been poorly studied. OBJECTIVE: To evaluate the association of single and multilocus haplotypes in genes coding for the viral co-receptors CCR5 and CCR2, and their ligands CCL3 and CCL5, with resistance or susceptibility to HIV-1 infection. MATERIALS AND METHODS: Nine variants in CCR5-CCR2, two SNPs in CCL3 and two in CCL5 were genotyped by PCR-RFLP in 35 seropositive (cases) and 49 HIV-1-exposed seronegative Colombian individuals (controls)...
June 1, 2017: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/28527283/-frequency-of-helicobacter-pylori-nitroreductase-rdxa-mutations-for-metronidazole-activation-in-a-population-in-the-cauca-department-colombia
#7
Claudia Patricia Acosta, Andrés Javier Quiroga, Carlos H Sierra, Alba Alicia Trespalacios
INTRODUCTION: Resistance to metronidazole is a key factor associated with Helicobacter pylori treatment failure. Even though resistance is mostly associated with RdxA nitroreductase mutations, studies of this H. pylori protein in Popayán (Colombia) are still incipient. OBJECTIVE: To evaluate the frequency of mutations in the RdxA nitroreductase in a population of patients with H. pylori-positive gastrointestinal disease. MATERIALS AND METHODS: We amplified the DNA of 170 gastric biopsies by PCR to detect mutations in the RdxA nitroreductase...
June 1, 2017: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/28527273/-reliability-and-dimensionality-of-phq-9-in-screening-depression-symptoms-among-health-science-students-in-cartagena-2014
#8
Carlos Arturo Cassiani-Miranda, María Camila Vargas-Hernández, Eduard Pérez-Anibal, Mariana Isabel Herazo-Bustos, Mauricio Hernández-Carrillo
INTRODUCTION: Depression among university students must be screened with valid instruments. The Patient Health Questionnaire (PHQ-9) is reliable and valid for screening depression in a university context; however, its psychometric performance in Colombia is unknown. OBJECTIVE: To estimate the reliability and dimensionality of PHQ-9 as a screening instrument for depressive symptoms among health sciences students of a university in Cartagena, Colombia.Materials y methods: We analyzed the factorial structure and reliability of the PHQ-9 in a sample of 550 students for expected prevalence of clinically-meaningful depressive symptoms (CMDS) of 25% with a confidence level of 95% and an error level of 3%...
April 1, 2017: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/28527271/self-rated-health-multimorbidity-and-depression-in-mexican-older-adults-proposal-and-evaluation-of-a-simple-conceptual-model
#9
Eduardo Bustos-Vázquez, Julián Alfredo Fernández-Niño, Claudia Iveth Astudillo-Garcia
INTRODUCTION: Self-rated health is an individual and subjective conceptualization involving the intersection of biological, social and psychological factors. It provides an invaluable and unique evaluation of a person's general health status. OBJECTIVE: To propose and evaluate a simple conceptual model to understand self-rated health and its relationship to multimorbidity, disability and depressive symptoms in Mexican older adults. MATERIALS AND METHODS: We conducted a cross-sectional study based on a national representative sample of 8,874 adults of 60 years of age and older...
April 1, 2017: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/28527232/three-dimensional-evaluation-of%C3%A2-postural%C3%A2-stability-in-parkinson-s-disease-with-mobile-technology
#10
Sarah J Ozinga, Mandy Miller Koop, Susan M Linder, Andre G Machado, Tanujit Dey, Jay L Alberts
BACKGROUND: Postural instability is a hallmark of Parkinson's disease. Objective metrics to characterize postural stability are necessary for the development of treatment algorithms to aid in the clinical setting. OBJECTIVE: The aim of this project was to validate a mobile device platform and resultant three-dimensional balance metric that characterizes postural stability. METHODS: A mobile Application was developed, in which biomechanical data from inertial sensors within a mobile device were processed to characterize movement of center of mass in the medial-lateral, anterior-posterior and trunk rotation directions...
May 13, 2017: NeuroRehabilitation
https://www.readbyqxmd.com/read/28527210/cerebrospinal-fluid-biomarkers-and-clinical-progression-in-patients-with-subjective-cognitive-decline-and-mild-cognitive-impairment
#11
Steffen Wolfsgruber, Alexandra Polcher, Alexander Koppara, Luca Kleineidam, Lutz Frölich, Oliver Peters, Michael Hüll, Eckart Rüther, Jens Wiltfang, Wolfgang Maier, Johannes Kornhuber, Piotr Lewczuk, Frank Jessen, Michael Wagner
BACKGROUND: There is very limited data on the prevalence of abnormal cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease (AD) and their predictive value for clinical progression in memory clinic patients with subjective cognitive decline (SCD). OBJECTIVE: To assess the frequency of abnormal CSF biomarkers of AD and their predictive value for clinical progression in memory clinic patients with SCD in comparison to patients with mild cognitive impairment (MCI) from the same cohort...
May 13, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28527162/evaluation-of-the-association-between-cd4-cd8-and-cd25-cell-counts-and-sle-in-active-disease-and-in-remission
#12
Archana Sonawale, Vinay Bohara, L S Bichile
AIM: To evaluate the correlation between the levels of CD4, CD8 and CD25 cells and SLE disease in active phase and in remission. METHODS: A total of 25 SLE patients, aged between 18-60 years, and fulfilling the ACR criteria with preferential Renal and CNS involvement were included in this study. Baseline CD4/CD8 and CD25 counts, lab parameters etc were conducted. Approximately at the end of 6 months with the settlement of the disease activity blood sample was drawn for the CD4, CD8 and CD25 counts and other lab parameters...
April 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/28527138/application-of-hyper-branched-rolling-circle-amplification-hrca-and-hrca-based-strip-test-for-the-detection-of-chattonella-marina
#13
Xiaoli Nie, Chunyun Zhang, Yuanyuan Wang, Changlu Guo, Jin Zhou, Guofu Chen
Harmful algal blooms (HABs) are global threats to marine ecosystems, fisheries, and human health. Therefore, developing effective and accurate methods for identifying causative algae and monitoring seawater quality is urgent. However, traditional, microscopy-based methods are complex, inaccurate, and time-consuming. Here, we present a novel method for effective and sensitive detection of Chattonella marina using hyper-branched rolling circle amplification (HRCA) and HRCA-based strip test (HBST). The large subunit (LSU) ribosomal DNA (rDNA) D1-D2 region of C...
May 19, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28527137/genome-based-identification-of-heterotic-patterns-in-rice
#14
Ulrike Beukert, Zuo Li, Guozheng Liu, Yusheng Zhao, Nadhigade Ramachandra, Vilson Mirdita, Fabiano Pita, Klaus Pillen, Jochen Christoph Reif
BACKGROUND: Hybrid rice breeding facilitates to increase grain yield and yield stability. Long-term success of hybrid breeding depends on the recognition of high-yielding complementary heterotic patterns, which is lacking in crops like rice. RESULT: The main goal of this study was to evaluate the potential and limits to use genomics for establishing heterotic patterns in rice. For this purpose, data of a commercial hybrid rice breeding program targeted to India was analyzed, including 1,960 phenotyped hybrids from three market segments and 262 genotyped parental lines...
December 2017: Rice
https://www.readbyqxmd.com/read/28527134/comparison-of-nurses-and-general-caregivers-knowledge-attitude-and-practice-on-medication-administration-process-and-their-distress-level-in-long-term-care-facilities-across-penang-kuala-lumpur-and-selangor-of-malaysia
#15
Balamurugan Tangiisuran, Sok Cin Tye, May Yen Leow, Rahmat Awang
AIM: Comparing nurses and general caregivers' knowledge, attitude, and practices (KAP) on medication administration process in long-term care (LTC) setting and an assessment of their stress, anxiety, and depression (SAD) level. METHODS: A cross-sectional survey was conducted among nurses and general caregivers working in LTC using a validated questionnaire. Consisting of demographic characteristics (Section 1); 40 questions on KAP (Section 2); and assessment of Depression, Anxiety, and Stress Scale (DASS-21) (Section 3)...
May 19, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28527121/brief-biofeedback-intervention-on-anxious-freshman-university-students
#16
Paulo Chaló, Anabela Pereira, Patrícia Batista, Luis Sancho
The increasing number of mental health disorders on university students represents a growing problem with negative impact on this population. Stress and anxiety issues are two of most predominant problems in this population and most campus health services have limited resources to face them. Research has provided evidence about biofeedback effectiveness. This study aims to verify the impact of a short duration biofeedback programme on freshmen university students with high levels of anxiety. A sample of 50 first-year students, with scores above percentile of 75 on STAI Y-2 were randomly selected and divided into two groups...
May 19, 2017: Applied Psychophysiology and Biofeedback
https://www.readbyqxmd.com/read/28527107/an-immune-related-six-lncrna-signature-to-improve-prognosis-prediction-of-glioblastoma-multiforme
#17
Meng Zhou, Zhaoyue Zhang, Hengqiang Zhao, Siqi Bao, Liang Cheng, Jie Sun
Recent studies have demonstrated the utility and superiority of long non-coding RNAs (lncRNAs) as novel biomarkers for cancer diagnosis, prognosis, and therapy. In the present study, the prognostic value of lncRNAs in glioblastoma multiforme was systematically investigated by performing a genome-wide analysis of lncRNA expression profiles in 419 glioblastoma patients from The Cancer Genome Atlas (TCGA) project. Using survival analysis and Cox regression model, we identified a set of six lncRNAs (AC005013.5, UBE2R2-AS1, ENTPD1-AS1, RP11-89C21...
May 19, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28527100/parents-expectations-of-high-schools-in-firearm-violence-prevention
#18
Erica Payton, Jagdish Khubchandani, Amy Thompson, James H Price
Firearm violence remains a significant problem in the US (with 2787 adolescents killed in 2015). However, the research on school firearm violence prevention practices and policies is scant. Parents are major stakeholders in relation to firearm violence by youths and school safety in general. The purpose of this study was to examine what parents thought schools should be doing to reduce the risk of firearm violence in schools. A valid and reliable questionnaire was mailed to a national random sample of 600 parents who had at least one child enrolled in a public secondary school (response rate = 47%)...
May 19, 2017: Journal of Community Health
https://www.readbyqxmd.com/read/28527097/the-flexibility-scale-development-and-preliminary-validation-of-a-cognitive-flexibility-measure-in-children-with-autism-spectrum-disorders
#19
John F Strang, Laura G Anthony, Benjamin E Yerys, Kristina K Hardy, Gregory L Wallace, Anna C Armour, Katerina Dudley, Lauren Kenworthy
Flexibility is a key component of executive function, and is related to everyday functioning and adult outcomes. However, existing informant reports do not densely sample cognitive aspects of flexibility; the Flexibility Scale (FS) was developed to address this gap. This study investigates the validity of the FS in 221 youth with ASD and 57 typically developing children. Exploratory factor analysis indicates a five-factor scale: Routines/rituals, transitions/change, special interests, social flexibility, and generativity...
May 19, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28527063/the-role-of-anti-cgrp-antibodies-in-the-pathophysiology-of-primary-headaches
#20
Piero Barbanti, Cinzia Aurilia, Luisa Fofi, Gabriella Egeo, Patrizia Ferroni
Calcitonin gene-related peptide (CGRP), a potent vasodilator and pain-signaling neuropeptide, is a validated therapeutic target for migraine and cluster headache. Four anti-CGRP monoclonal antibodies (mAbs) have been developed, representing the first specific, mechanism-based, migraine prophylactic treatment. CGRP mAbs demonstrated good efficacy coupled to excellent tolerability and safety in 5 phase II clinical trials. Notably, CGRP mAbs induced complete migraine remission in a patients' subset. To date, more than 20 phase III trials using CGRP mAbs for of episodic and chronic migraine and cluster headache prevention are ongoing...
May 2017: Neurological Sciences
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