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Narayan Balaji, Suresh P Sulochana, Neeraj Kumar Saini, Siva Kumar A, Ramesh Mullangi
A simple, selective and reliable LC-MS/MS method was developed and validated for the simultaneous quantitation of darolutamide diastereomers (diastereomer-1 and diastereomer-2) and its active metabolite i. e. ORM-15341 in mice plasma using warfarin as an internal standard (IS) as per the regulatory guidelines. Plasma samples were extracted by liquid-liquid extraction and the chromatographic separation was achieved on a Chiralpak IA column with an isocratic mobile phase 5 mM ammonium acetate:absolute alcohol (20:80, v/v) at a flow rate of 1...
March 20, 2018: Drug Research
Sorina Suarasan, Emilia Licarete, Simion Astilean, Ana-Maria Craciun
Nowadays, the non-linear optical effect of two-photon excited (TPE) fluorescence has recently grown in interest in recent years over other optical imaging method, due to improved 3D spatial resolution, deep penetrability and less photodamage of living organism owing to the excitation in near-infrared region (NIR). In parallel, gold nanoparticles (AuNPs) have gain considerable attention for NIR TPE bio-imaging applications due to their appealing ability to generate strong intrinsic photoluminescence (PL). Here, we demonstrate the capability of differently shaped gelatin-coated AuNPs to perform as reliable label-free contrast agents for the non-invasive NIR imaging of NIH:OVCAR-3 ovary cancer cells via TPE Fluorescence Lifetime Imaging Microscopy (FLIM)...
March 14, 2018: Colloids and Surfaces. B, Biointerfaces
Jarunya Samsuwan, Tachapol Muangsub, Pattamawadee Yanatatsaneejit, Apiwat Mutirangura, Nakarin Kitkumthorn
According to the tissue-specific methylation database (doi: 10.1016/j.gene.2014.09.060), methylation at CpG locus cg03096975 in EML2 has been preliminarily proven to be specific to brain tissue. In this study, we enlarged sample size and developed a technique for identifying brain tissue in aged samples. Combined Bisulfite Restriction Analysis-for EML2 (COBRA-EML2) technique was established and validated in various organ samples obtained from 108 autopsies. In addition, this technique was also tested for its reliability, minimal DNA concentration detected, and use in aged samples and in samples obtained from specific brain compartments and spinal cord...
March 9, 2018: Forensic Science International
Kimberly S Chiew, Jordan Hashemi, Lee K Gans, Laura Lerebours, Nathaniel J Clement, Mai-Anh T Vu, Guillermo Sapiro, Nicole E Heller, R Alison Adcock
Volitional exploration and learning are key to adaptive behavior, yet their characterization remains a complex problem for cognitive science. Exploration has been posited as a mechanism by which motivation promotes memory, but this relationship is not well-understood, in part because novel stimuli that motivate exploration also reliably elicit changes in neuromodulatory brain systems that directly alter memory formation, via effects on neural plasticity. To deconfound interrelationships between motivation, exploration, and memory formation we manipulated motivational state prior to entering a spatial context, measured exploratory responses to the context and novel stimuli within it, and then examined motivation and exploration as predictors of memory outcomes...
2018: PloS One
Cornelia Wiegand, Andrea Völpel, Andrea Ewald, Markko Remesch, Jan Kuever, Janine Bauer, Stefanie Griesheim, Carolin Hauser, Julian Thielmann, Silke Tonndorf-Martini, Bernd W Sigusch, Jürgen Weisser, Ralf Wyrwa, Peter Elsner, Uta-Christina Hipler, Martin Roth, Carolin Dewald, Claudia Lüdecke-Beyer, Jörg Bossert
Bactericidal materials gained interest in the health care sector as they are capable of preventing material surfaces from microbial colonization and subsequent spread of infections. However, commercialization of antimicrobial materials requires proof of their efficacy, which is usually done using in vitro methods. The ISO 22196 standard (Japanese test method JIS Z 2801) is a method for measuring the antibacterial activity of daily goods. As it was found reliable for testing the biocidal activity of antimicrobially active materials and surface coatings most of the laboratories participating in this study used this protocol...
2018: PloS One
David Perez-Diaz-de-Cerio, Ángela Hernández-Solana, Antonio Valdovinos, Jose Luis Valenzuela
Timing points used in running races and other competition events are generally based on radio-frequency identification (RFID) technology. Athletes' times are calculated via passive RFID tags and reader kits. Specifically, the reader infrastructure needed is complex and requires the deployment of a mat or ramps which hide the receiver antennae under them. Moreover, with the employed tags, it is not possible to transmit additional and dynamic information such as pulse or oximetry monitoring, alarms, etc. In this paper we present a system based on two low complex schemes allowed in Bluetooth Low Energy (BLE): the non-connectable undirected advertisement process and a modified version of scannable undirected advertisement process using the new capabilities present in Bluetooth 5...
March 20, 2018: Sensors
Caitlin R Woolcott, Stephanie Torrey, Patricia V Turner, Lilia Serpa, Karen Schwean-Lardner, Tina M Widowski
On-farm euthanasia is a critical welfare issue in the poultry industry and can be particularly difficult to perform on mature turkeys due to their size. We evaluated the efficacy of two commercially available non-penetrating captive bolt devices, the Zephyr-EXL and the Turkey Euthanasia Device (TED), on 253 turkeys at three stages of production: 4-5, 10, and 15-20 weeks of age. Effectiveness of each device was measured using both ante- and post-mortem measures. Application of the Zephyr-EXL resulted in a greater success rate (immediate abolishment of brainstem reflexes) compared to the TED (97...
March 20, 2018: Animals: An Open Access Journal From MDPI
Heekyeong Park, Sungho Lee, Seok Hwan Jeong, Ui Hyun Jung, Kidong Park, Min Goo Lee, Sunkook Kim, Joonhyung Lee
Flexible sensors connected to cell phones are a promising technology that can aid in continuously monitoring signals in our daily lives, such as an individual's health status and information from buildings, farms, and industry. Among such signals, real-time humidity monitoring is crucial to a comfortable life, as human bodies, plants, and industrial environments require appropriate humidity to be maintained. We propose a hydrophilic polytetrafluoroethylene (H-PTFE)-based flexible humidity sensor integrated with readout circuitry, wireless communication, and a mobile battery...
March 20, 2018: Sensors
Ali Al-Naji, Javaan Chahl
Monitoring of cardiopulmonary activity is a challenge when attempted under adverse conditions, including different sleeping postures, environmental settings, and an unclear region of interest (ROI). This study proposes an efficient remote imaging system based on a Microsoft Kinect v2 sensor for the observation of cardiopulmonary-signal-and-detection-related abnormal cardiopulmonary events (e.g., tachycardia, bradycardia, tachypnea, bradypnea, and central apnoea) in many possible sleeping postures within varying environmental settings including in total darkness and whether the subject is covered by a blanket or not...
March 20, 2018: Sensors
Dominik Kowal, Waclaw Urbanczyk, Pawel Mergo
In this paper we present an all-fiber interferometric sensor for the simultaneous measurement of strain and temperature. It is composed of a specially fabricated twin-core fiber spliced between two pieces of a single-mode fiber. Due to the refractive index difference between the two cores in a twin-core fiber, a differential interference pattern is produced at the sensor output. The phase response of the interferometer to strain and temperature is measured in the 850-1250 nm spectral range, showing zero sensitivity to strain at 1000 nm...
March 20, 2018: Sensors
Yu-Chuan Chiu, Shen-Ing Liu, Chen-Ju Lin, Yu-Shin Huang, Chun-Kai Fang, Fang-Ju Sun, Kai-Liang Kao, Yo-Ping Huang, Shu-I Wu
This study examines the reliability, factor structure, convergent, and construct validities of the Mandarin Chinese version of the Reasons For Living Inventory (RFL) among Taiwanese psychiatric patients. Demographical characteristics of patients who hold these adaptive cognitions and differences on the level of endorsement between suicidal and non-suicidal individuals were also investigated. All adult patients that had visited the psychiatric ambulatory clinic or had been admitted to the psychiatric ward in a general hospital in Taiwan over a 3-month period were consecutively invited to complete an inventory that included background information, the Mandarin Chinese versions of the RFL, the Suicidal Behaviors Questionnaire- Revised (SBQ-R), and the Beck Hopeless Scale (BHS)...
March 20, 2018: Behavioral Medicine
Michael James Eastwood, And Ajith Paulose George
Intraoperative identification of the spinal accessory nerve (SAN) is key in reducing nerve injury. This study aims to explore the surgical anatomy of the SAN and 2 landmarks for its identification-the sternocleidomastoid branch of the occipital artery (SBOA) and superior sternocleidomastoid tendon (SST)-to propose a novel method of identifying the SAN during surgical neck dissections. Twelve cadavers underwent bilateral level II-V neck dissection identifying the SAN, SBOA, and SST. Variation was documented and distance between landmarks and the SAN measured...
March 1, 2018: Otolaryngology—Head and Neck Surgery
Sean P Riley, Vincent Tafuto, Mark Cote, Jean-Michel Brismée, Alexis Wright, Chad Cook
PURPOSE: The purpose of this study was to determine: 1) the test-retest reliability of Fear-Avoidance Beliefs Questionnaire (FABQ) Work (FABQW) subscale, FABQ Physical Activity (FABQPA) subscale, Shoulder Pain and Disability Index (SPADI) Pain subscale, SPADI Disability subscale, and Numeric Pain Rating scale (NPRS); and 2) the relationship between the FABQPA, FABQW, SPADI pain, SPADI disability, and NPRS after 4 weeks of pragmatically applied physical therapy (PT) in patients with shoulder pain...
March 20, 2018: Physiotherapy Theory and Practice
Grant Waterer, James Chalmers
No abstract text is available yet for this article.
March 20, 2018: American Journal of Respiratory and Critical Care Medicine
Suji Gim, Hyung-Kyu Lim, Hyungjun Kim
The solid-liquid interface is of great interest because of its highly heterogeneous character and its ubiquity in various applications. The most fundamental physical variable determining the strength of the solid-liquid interface is the solid-liquid interfacial tension, which is usually measured according to the contact angle. However, an accurate experimental measurement and a reliable theoretical prediction of the contact angle remain lacking because of many practical issues. Here, we propose a first principles-based simulation approach to quantitatively predict the contact angle of an ideally clean surface using our recently developed multiscale simulation method of density functional theory in classical explicit solvents (DFT-CES)...
March 20, 2018: Journal of Physical Chemistry Letters
Marcin Frączek, Marcin Masalski, Maciej Guziński
BACKGROUND: Paranasal computed tomography (CT) has become the investigation method of choice to confirm or exclude the diagnosis of chronic rhinosinusitis (CRS) on the basis of its ability to deliver objective data regarding the presence of inflamed mucosa or polyps. OBJECTIVES: The aim of the study was to assess the reliability of CT scan findings among untreated CRS patients without the presence of polyps in a nasal endoscopy. MATERIAL AND METHODS: Among patients with clinically demonstrated CRS considered for surgery, 93 subjects who had had 2 CT scans performed at different time points in the diagnostic process were enrolled into the study...
March 19, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
Pablo Santos-Iglesias, Bijan Mohamed, Angela Danko, Lauren M Walker
This manuscript is the first to examine the psychometric properties of the Female Sexual Distress Scale in samples of sexually functional and dysfunctional men, herein called the Sexual Distress Scale (SDS). A sample of 127 sexually dysfunctional men and 267 sexually functional men completed an online survey that included a sociodemographic questionnaire, a health questionnaire, the SDS, as well as measures of sexual bother and concerns, sexual function, sexual attitudes, and mood states. We also used a sample of 188 sexually dysfunctional and 155 sexually functional women from previous studies...
March 20, 2018: Archives of Sexual Behavior
Lelia Barks, Cynthia Garvan, Barbara Crane, Matthew Peterson, Lisa M Brown, Gail Powell-Cope
PURPOSE: Earlier, we reported development and initial testing of a rapid, low burden measure of wheelchair seated posture (the Seated Posture Scale [SPS]) for research and clinical use. The purpose of this study was to test the intrarater reliability, interrater reliability, and criterion related validity of the SPS. DESIGN: We used a descriptive design to test and develop the instrument. METHODS: We used the method described by Walter, Donner, and Eliasziw to determine 46 participants were needed, from two Veterans Administration nursing homes or CLCs (community living centers)...
March 19, 2018: Rehabilitation Nursing: the Official Journal of the Association of Rehabilitation Nurses
Sam Denys, Michael Hofmann, Heleen Luts, Cécile Guérin, Ann Keymeulen, Katelijne Van Hoeck, Astrid van Wieringen, Karel Hoppenbrouwers, Jan Wouters
OBJECTIVES: This study aims to investigate the large-scale applicability of the Digit Triplet test (DTT) for school-age hearing screening in fifth grade elementary (5E) (9 to 12 years old) and third grade secondary (3S) (13 to 16 years old) school children. The reliability of the test is investigated as well as whether pass/fail criteria need to be corrected for training and/or age, and whether these criteria have to be refined with respect to referral rates and pure-tone audiometry results...
March 19, 2018: Ear and Hearing
Marek E Schmidt, Ahmed M M Hammam, Takuya Iwasaki, Teruhisa Kanzaki, Manoharan Muruganathan, Shinichi Ogawa, Hiroshi Mizuta
Carbon nanoscrolls (CNS) with their open ended morphology have recently attracted interest due to the potential application in gas capture, biosensors and interconnects. However, CNS currently suffer from the same issue that have hindered widespread integration of CNTs in sensors and devices: Formation is done ex-situ, and the tubes have to be placed with precision and reliability - a difficult task with low yield. Here, we demonstrate controlled in-situ formation of electrically contacted CNS from suspended graphene nanoribbons (GNRs) with slight tensile stress...
March 20, 2018: Nanotechnology
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