keyword
https://read.qxmd.com/read/38454851/phosphoproteomics-revealed-differentially-expressed-sites-and-function-of-the-bovine-milk-fat-globule-membrane-in-colostrum-and-mature-milk
#21
JOURNAL ARTICLE
Xue Bai, Jingwen Shang, Chunshuang Wu, Hong Yu, Xinping Chen, Xiqing Yue, Mei Yang
One type of large and intricate post-translational modification of milk proteins that has significant biological implications is phosphorylation. The characterization of phosphoproteins found in the bovine milk fat globule membrane (MFGM) is still mostly unknown. Here, label-free phosphoproteomics was used to identify 94 phosphorylation sites from 54 MFGM phosphoproteins in bovine colostrum (BC) and 136 phosphorylation sites from 91 MFGM phosphoproteins in bovine mature milk (BM). αs1-Casein and β-casein were the most phosphorylated proteins in bovine colostrum...
March 8, 2024: Journal of Agricultural and Food Chemistry
https://read.qxmd.com/read/38454404/cyclin-a1-ccna1-inhibits-osteoporosis-by-suppressing-transforming-growth-factor-beta-tgf-beta-pathway-in-osteoblasts
#22
JOURNAL ARTICLE
Xiao Du, Chuanyi Zang, Qinglei Wang
BACKGROUND: Osteoporosis is a genetic disease caused by the imbalance between osteoblast-led bone formation and osteoclast-induced bone resorption. However, further gene-related pathogenesis remains to be elucidated. METHODS: The aberrant expressed genes in osteoporosis was identified by analyzing the microarray profile GSE100609. Serum samples of patients with osteoporosis and normal group were collected, and the mRNA expression of candidate genes was detected by quantitative real-time polymerase chain reaction (qRT-PCR)...
March 7, 2024: BMC Musculoskeletal Disorders
https://read.qxmd.com/read/38451263/changes-in-biomarkers-levels-from-gingival-crevicular-fluid-in-pre-and-postmenopausal-women-undergoing-orthodontic-treatment-a%C3%A2-systematic-review
#23
JOURNAL ARTICLE
Deborah Ribeiro Frazão, Yago Gecy de Souza Né, Maria Karolina Martins Ferreira, Nathália Carolina Fernandes Fagundes, Guido Marañón-Vásquez, Lucianne Cople Maia, Matheus Melo Pithon, Rafael Rodrigues Lima
PURPOSE: This study aimed to verify whether there is a difference in biomarker levels in the gingival crevicular fluid between premenopausal and postmenopausal women undergoing orthodontic treatment. METHODS: As eligibility criteria, prospective or retrospective observational studies evaluating women undergoing orthodontic treatment (P), comparing postmenopausal (E) and premenopausal (C) women, and analyzing differences in gingival crevicular fluid biomarkers (O) were included...
March 7, 2024: Journal of Orofacial Orthopedics
https://read.qxmd.com/read/38448282/corrigendum-to-osteopontin-modulates-microglial-activation-states-and-attenuates-inflammatory-responses-after-subarachnoid-hemorrhage-in-rats-experimental-neurology-371-2024-114585
#24
Chengmei Sun, Muhammad Saif Ur Rahman, Budbazar Enkhjargal, Jianhua Peng, Keren Zhou, Zhiyi Xie, Lingyun Wu, Tongyu Zhang, Qiquan Zhu, Jiping Tang, Yujia Zeng, John H Zhang, Shanshan Xu
No abstract text is available yet for this article.
March 6, 2024: Experimental Neurology
https://read.qxmd.com/read/38443978/mechanism-of-kdm5a-mediated-h3k4me3-modification-in-the-osteogenic-differentiation-of-mesenchymal-stem-cells-in-steroid-induced-osteonecrosis-of-the-femoral-head
#25
JOURNAL ARTICLE
Yi Yan, Hao Yan, Zhilong Qiu, Liang Long
OBJECTIVES: Steroid-induced osteonecrosis of the femoral head (SONFH) is characterized by impaired osteogenesis in bone marrow mesenchymal stem cells (BMSCs). This study investigates the role of lysine-specific demethylase 5A (KDM5A) in SONFH to identify potential therapeutic targets. METHODS: Human BMSCs were isolated and characterized for cell surface markers and differentiation capacity. A SONFH cell model was established using dexamethasone treatment. BMSCs were transfected with KDM5A overexpression vectors or si-KDM5A, and the expression of KDM5A, miR-107, runt-related transcription factor 2 (RUNX2), osteocalcin (OCN), and osteopontin (OPN) was assessed...
March 2024: International Journal of Rheumatic Diseases
https://read.qxmd.com/read/38443806/osteopontin-osteoprotegerin-and-musculoskeletal-ultrasound-findings-in-first-degree-relatives-of-rheumatoid-arthritis-potential-markers-of-preclinical-disease
#26
JOURNAL ARTICLE
Eiman Soliman, Sarah Ohrndorf, Magdy Zehairy, Khaled Matrawy, Abeer Alhadidy, Abeer Abdelati
BACKGROUND: First-degree relatives (FDRs) of rheumatoid arthritis (RA) patients are known to have increased risk of developing the disease. The detection of altered bone metabolism in FDRs could be a predictor of the disease. Musculoskeletal ultrasound (MSUS) is known for its ability to detect subclinical joint inflammation in RA, but changes in FDRs are not yet described. We aimed to study serum Osteopontin (OPN) and Osteoprotegerin (OPG) levels in FDRs of RA patients as markers of altered bone metabolism in relation to clinical, laboratory and musculoskeletal ultrasound (MSUS) findings...
March 5, 2024: BMC Musculoskeletal Disorders
https://read.qxmd.com/read/38431384/epidemiological-and-biological-associations-between-cardiovascular-disease-and-kidney-stone-formation-a-systematic-review-and-meta-analysis
#27
JOURNAL ARTICLE
Luke Muschialli, Ankith Mannath, Shabbir H Moochhala, Rukshana Shroff, Pietro Manuel Ferraro
AIMS: Previous studies find kidney stone formers (KSF) are at greater risk of developing cardiovascular disease (CVD). The underlying mechanisms are poorly understood, and many clinicians are unaware of this connection. We will: DATA SYNTHESIS: Our systematic review is registered with PROSPERO (ID CRD42021251477). We searched epidemiological and biological data. The epidemiological search generated 669 papers, narrowed down to 15. There were 4,259,869 participants (230,720 KSFs). KSF was associated with 25% higher risk of coronary artery disease (CAD) (95% confidence interval (CI): 15, 35%), 17% higher risk of stroke/transient ischemic attacks (TIA) (CI:10, 25%) and 39% higher risk of arterial disease (AD) (CI: 17 65%)...
March 2024: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://read.qxmd.com/read/38427280/a-phase-ii-study-of-folfiri-plus-ziv-aflibercept-after-trifluridine-tipiracil-plus-bevacizumab-in-patients-with-metastatic-colorectal-cancer-wjog-11018g
#28
JOURNAL ARTICLE
Toshihiko Matsumoto, Yoshiyuki Yamamoto, Masahito Kotaka, Toshiki Masuishi, Yasushi Tsuji, Hirokazu Shoji, Kenro Hirata, Takao Tsuduki, Akitaka Makiyama, Naoki Izawa, Naoki Takahashi, Masahiro Tsuda, Hisateru Yasui, Takashi Ohta, Yosuke Kito, Satoshi Otsu, Shuichi Hironaka, Kentaro Yamazaki, Narikazu Boku, Ichinosuke Hyodo, Kenichi Yoshimura, Kei Muro
BACKGROUND: Non-inferiority of trifluridine/tipiracil (FTD/TPI) plus bevacizumab (BEV) to irinotecan/fluoropyrimidine plus BEV in metastatic colorectal cancer was investigated in the phase III TRUSTY study, and we conducted a phase II study of FOLFIRI (5-FU+leucovorin+irinotecan) plus zib-aflibercept (AFL) after FTD/TPI plus BEV. However, the TRUSTY study failed during the recruitment of our patients. OBJECTIVE: We present the findings of a phase II study on the efficacy of FOLFIRI plus zib-aflibercept (AFL) after FTD/TPI plus BEV, including clinical results with plasma biomarker analyses...
March 1, 2024: Targeted Oncology
https://read.qxmd.com/read/38426347/mineralocorticoid-receptors-in-vascular-smooth-muscle-blood-pressure-and-beyond
#29
REVIEW
Nicholas D Camarda, Jaime Ibarrola, Lauren A Biwer, Iris Z Jaffe
After half a century of evidence suggesting the existence of mineralocorticoid receptors (MR) in the vasculature, the advent of technology to specifically knockout the MR from smooth muscle cells (SMCs) in mice has elucidated contributions of SMC-MR to cardiovascular function and disease, independent of the kidney. This review summarizes the latest understanding of the molecular mechanisms by which SMC-MR contributes to (1) regulation of vasomotor function and blood pressure to contribute to systemic and pulmonary hypertension; (2) vascular remodeling in response to hypertension, vascular injury, obesity, and aging, and the impact on vascular calcification; and (3) cardiovascular pathologies including aortic aneurysm, heart valve dysfunction, and heart failure...
March 1, 2024: Hypertension
https://read.qxmd.com/read/38426086/enhancing-immune-regulation-in-vitro-the-synergistic-impact-of-3-sialyllactose-and-osteopontin-in-a-nutrient-blend-following-influenza-virus-infection
#30
JOURNAL ARTICLE
Zhengtao Guo, Qinggang Xie, Qiqi Ren, Yang Liu, Kaifeng Li, Bailiang Li, Jufang Li
Natural components of breast milk, human milk oligosaccharides (HMOs) and osteopontin (OPN) have been shown to have a variety of functional activities and are widely used in infant formulas. However, the preventive and therapeutic effects of both on influenza viruses are not known. In this study, antiviral assays using a human laryngeal carcinoma cell line (HEP-2) showed that 3'-sialyllactose (3'-SL) and OPN had the best antiviral ability with IC50 values of 33.46 μM and 1.65 μM, respectively. 3'-SL (10 μM) and OPN (4 μM) were used in combination to achieve 75% inhibition...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38424446/denervation-alters-the-secretome-of-myofibers-and-thereby-affects-muscle-stem-cell-lineage-progression-and-functionality
#31
JOURNAL ARTICLE
Henriette Henze, Sören S Hüttner, Philipp Koch, Svenja C Schüler, Marco Groth, Björn von Eyss, Julia von Maltzahn
Skeletal muscle function crucially depends on innervation while repair of skeletal muscle relies on resident muscle stem cells (MuSCs). However, it is poorly understood how innervation affects MuSC properties and thereby regeneration of skeletal muscle. Here, we report that loss of innervation causes precocious activation of MuSCs concomitant with the expression of markers of myogenic differentiation. This aberrant activation of MuSCs after loss of innervation is accompanied by profound alterations on the mRNA and protein level...
March 1, 2024: NPJ Regenerative Medicine
https://read.qxmd.com/read/38417707/impact-of-humanized-vancomycin-infusion-on-kidney-function-and-kidney-injury-in-a-translational-rat-model
#32
JOURNAL ARTICLE
Jack Chang, Gwendolyn M Pais, Raymond Jubrail, Patti L Engel, Marc H Scheetz
Allometric dose scaling aims to create isometric exposures between animals and humans and is often employed in preclinical pharmacokinetic/pharmacodynamic models. Bolus dose allometric scaling is the most simple and commonly used strategy in kidney injury studies; however, it is possible to humanize drug exposures. Currently, it is unknown if dose-matched bolus allometric scaling results in similar outcomes to humanized infusions in the vancomycin induced kidney injury model. We utilized a preclinical Sprague-Dawley rat model to compare traditional allometrically scaled dose-matched bolus administration of vancomycin to a computer-controlled and humanized infusion scheme to assess for differences in iohexol-measured kidney function and urinary kidney injury biomarkers...
February 26, 2024: International Journal of Antimicrobial Agents
https://read.qxmd.com/read/38416830/an-immunosuppressive-vascular-niche-drives-macrophage-polarization-and-immunotherapy-resistance-in-glioblastoma
#33
JOURNAL ARTICLE
Fan Yang, Md Naushad Akhtar, Duo Zhang, Rakan El-Mayta, Junyoung Shin, Jay F Dorsey, Lin Zhang, Xiaowei Xu, Wei Guo, Stephen J Bagley, Serge Y Fuchs, Constantinos Koumenis, Justin D Lathia, Michael J Mitchell, Yanqing Gong, Yi Fan
Cancer immunity is subjected to spatiotemporal regulation by leukocyte interaction with neoplastic and stromal cells, contributing to immune evasion and immunotherapy resistance. Here, we identify a distinct mesenchymal-like population of endothelial cells (ECs) that form an immunosuppressive vascular niche in glioblastoma (GBM). We reveal a spatially restricted, Twist1/SATB1-mediated sequential transcriptional activation mechanism, through which tumor ECs produce osteopontin to promote immunosuppressive macrophage (Mφ) phenotypes...
March 2024: Science Advances
https://read.qxmd.com/read/38416687/spatial-growth-factor-delivery-for-3d-bioprinting-of-vascularized-bone-with-adipose-derived-stem-stromal-cells-as-a-single-cell-source
#34
JOURNAL ARTICLE
Meric Goker, Utku Serhat Derici, Seyda Gokyer, Mehmet Goktug Parmaksiz, Burak Kaya, Alp Can, Pinar Yilgor
Encapsulating multiple growth factors within a scaffold enhances the regenerative capacity of engineered bone grafts through their localization and controls the spatiotemporal release profile. In this study, we bioprinted hybrid bone grafts with an inherent built-in controlled growth factor delivery system, which would contribute to vascularized bone formation using a single stem cell source, human adipose-derived stem/stromal cells (ASCs) in vitro. The strategy was to provide precise control over the ASC-derived osteogenesis and angiogenesis at certain regions of the graft through the activity of spatially positioned microencapsulated BMP-2 and VEGF within the osteogenic and angiogenic bioink during bioprinting...
February 28, 2024: ACS Biomaterials Science & Engineering
https://read.qxmd.com/read/38407428/correlation-of-osteopontin-hormone-with-timi-score-and-cardiac-markers-in-patients-with-acute-coronary-syndrome-presenting-with-chest-pain
#35
JOURNAL ARTICLE
Ayşe Şule Akan, Ibrahim Özlü
AIM: Rapid evaluation of patients with acute coronary syndrome (ACS) attending the emergency service under emergency room conditions and using appropriate risk scoring would improve treatment success. Calcium levels accumulate in the tissue in people with coronary artery disease and this has been found to correlate with osteopontin levels in some studies. It is predicted that osteopontin level could be used as a biomarker to detect coronary artery calcification. In this study, we aimed to evaluate the use of osteopontin levels in the differential diagnosis of ACS in conjunction with cardiac troponin I (cTnI) levels, and HEART (history, ECG, age, risk factors, troponin) and thrombolysis in myocardial infarction (TIMI) scores in patients with chest pain who attended the emergency service...
February 16, 2024: Cardiovascular Journal of Africa
https://read.qxmd.com/read/38404586/csf-levels-of-chitinase3like1-correlate-with-early-response-to-cladribine-in-multiple-sclerosis
#36
JOURNAL ARTICLE
Damiano Marastoni, Matteo Foschi, Chiara Eccher, Francesco Crescenzo, Valentina Mazziotti, Agnese Tamanti, Albulena Bajrami, Valentina Camera, Stefano Ziccardi, Maddalena Guandalini, Francesca Bosello, Daniela Anni, Federica Virla, Ermanna Turano, Michele Romoli, Raffaella Mariotti, Francesca Benedetta Pizzini, Bruno Bonetti, Massimiliano Calabrese
BACKGROUND: Cladribine has been introduced as a high-efficacy drug for treating relapsing-remitting multiple sclerosis (RRMS). Initial cohort studies showed early disease activity in the first year after drug initiation. Biomarkers that can predict early disease activity are needed. AIM: To estimate cerebrospinal fluid (CSF) markers of clinical and radiological responses after initiation of cladribine. METHODS: Forty-two RRMS patients (30F/12M) treated with cladribine were included in a longitudinal prospective study...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38400081/rosuvastatin-as-a-supplemental-treatment-for-the-clinical-symptoms-of-nephropathia-epidemica-a-pilot-clinical-study
#37
JOURNAL ARTICLE
Venera Shakirova, Maria Markelova, Yuriy Davidyuk, Robert J Stott-Marshall, Toshana L Foster, Svetlana Khaiboullina, Albert Rizvanov, Ekaterina Martynova
Nephropathis epidemica (NE), a mild form of hemorrhagic fever with renal syndrome (HFRS), is an acute zoonotic disease endemic in the Republic of Tatarstan. This study aimed to assess the impact of rosuvastatin on the clinical and laboratory results of NE. A total of 61 NE patients and 30 controls were included in this study; 22 NE patients and 7 controls received a daily dose of rosuvastatin (10 mg) for ten consecutive days. Serum samples were collected on days 1, 5, and 10 after admission to the hospital...
February 17, 2024: Viruses
https://read.qxmd.com/read/38395453/new-blood-biomarkers-and-imaging-for-disease-stratification-and-monitoring-of-giant-cell-arteritis
#38
JOURNAL ARTICLE
Alessandro Tomelleri, Christian Dejaco
Relapses and late complications remain a concern in giant cell arteritis (GCA). Monitoring strategies are required to effectively tailor treatment and improve patients' outcomes. Current monitoring of GCA is based on clinical assessment and evaluation of traditional inflammatory markers such as C reactive protein and erythrocyte sedimentation rate; however, this approach has limited value in patients receiving interleukin (IL)-6 blocking agents. New blood biomarkers that are less dependent on the IL-6 axis such as IL-23, B cell activating factor, osteopontin and calprotectin have been explored, but none of them has yet accumulated sufficient evidence to qualify as a routine follow-up parameter...
February 23, 2024: RMD Open
https://read.qxmd.com/read/38377607/role-of-cardiac-biomarkers-in-hepatic-disorders-a-literature-review
#39
JOURNAL ARTICLE
Saira Rafaqat, Irena Radoman Vujacic, Amir Hossein Behnoush, Saima Sharif, Aleksandra Klisic
Various studies have reported the association between cardiac markers and hepatic disorders. The main objective of this review article was to elucidate the significance of important cardiac indicators such as ischemia-modified albumin, cardiac troponin, cardiac natriuretic peptides, creatine kinase, creatine kinase-MB, lactate dehydrogenase, heart-type fatty acid-binding protein, osteopontin, soluble suppression of tumorigenicity 2, C-reactive protein, and lipoprotein(a) in the development of hepatic disorders...
February 20, 2024: Metabolic Syndrome and related Disorders
https://read.qxmd.com/read/38376506/prognostic-and-clinicopathological-value-of-osteopontin-expression-in-non-small-cell-lung-cancer-a-meta-analysis-and-systematic-review
#40
REVIEW
Yu Song, Haibo Li, Qing Jiang, Lianghong Wu
BACKGROUND: Although Osteopontin (OPN) has been reported to be associated with many different human cancers, the data on non-small cell lung cancer (NSCLC) are not definitive. This study aimed to explore the prognostic effect of OPN expression and clinicopathological characteristics in patients with NSCLC. METHODS: This study followed all aspects of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) report. PubMed, Embase and the Cochrane Library were searched to identify the relative studies...
February 20, 2024: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
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