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Interleukin 36

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https://www.readbyqxmd.com/read/29235214/the-effect-of-administration-of-copper-nanoparticles-to-chickens-in-their-drinking-water-on-the-immune-and-antioxidant-status-of-the-blood
#1
Katarzyna Ognik, Iwona Sembratowicz, Ewelina Cholewińska, Jan Jankowski, Krzysztof Kozłowski, Jerzy Juśkiewicz, Zenon Zduńczyk
The aim of this experiment was to determine what dosage of copper (Cu) nanoparticles, added to a standard dietary supplementation with copper sulfate, would improve antioxidant and immune defense in chickens. The experiment was conducted with 126 broiler chickens assigned to seven treatments with three pens per treatment and six broiler chickens per pen. The basal-diet treatment did not receive Cu nanoparticles (nano-Cu) and as shown by analyses it was Cu-deficient (-29% vs. National Research Council (NRC) recommendations; 5...
December 12, 2017: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/29209598/inflammatory-mediators-in-tracheal-aspirates-of-preterm-infants-participating-in-a-randomized-trial-of-permissive-hypercapnia
#2
Sarah Gentner, Mandy Laube, Ulrike Uhlig, Yang Yang, Hans W Fuchs, Jens Dreyhaupt, Helmut D Hummler, Stefan Uhlig, Ulrich H Thome
Background: Ventilator-induced lung injury is considered to be a main factor in the pathogenesis of bronchopulmonary dysplasia (BPD). Optimizing ventilator strategies may reduce respiratory morbidities in preterm infants. Permissive hypercapnia has been suggested to attenuate lung injury. We aimed to determine if a higher PCO2 target range results in less lung injury compared to the control target range and possibly reduces pro-inflammatory cytokines and acid sphingomyelinase (ASM) in tracheal aspirates (TA), which has not been addressed before...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29204094/the-significance-of-il-1%C3%AE-3953c-t-il-6-174g-c-and-596g-a-tnf-%C3%AE-308g-a-gene-polymorphisms-and-86-bp-variable-number-tandem-repeat-polymorphism-of-il-1rn-in-bronchopulmonary-dysplasia-in-infants-born-before-32-weeks-of-gestation
#3
Dawid Szpecht, Janusz Gadzinowski, Irmina Nowak, Dorothy Cygan, Agnieszka Seremak-Mrozikiewicz, Grażyna Kurzawińska, Dariusz Madajczak, Krzysztof Drews, Marta Szymankiewicz
Introduction: Bronchopulmonary dysplasia (BPD) is a chronic lung disease that affects primarily preterm infants. Genetic factors are also taken into consideration in the pathogenesis of BPD. Genetic predispositions to higher production of inflammation mediators seem to be crucial. Material and methods: The aim of this study was to evaluate the possible relationship between polymorphisms: interleukin-1β +3953 C>T, interleukin-6 -174 G>C and -596 G>A, tumour necrosis factor -308 G>A and interleukin-1RN VNTR 86bp and the occurrence of BPD in a population of 100 preterm infants born from singleton pregnancy, before 32+0 weeks of gestation, exposed to antenatal steroids therapy, and without congenital abnormalities...
2017: Central-European Journal of Immunology
https://www.readbyqxmd.com/read/29204057/novel-d-galactosamine-induced-cynomolgus-monkey-model-of-acute-liver-failure
#4
Lei Feng, Lei Cai, Guo-Lin He, Jun Weng, Yang Li, Ming-Xin Pan, Ze-Sheng Jiang, Qing Peng, Yi Gao
AIM: To establish a simplified, reproducible D-galactosamine-induced cynomolgus monkey model of acute liver failure having an appropriate treatment window. METHODS: Sixteen cynomolgus monkeys were randomly divided into four groups (A, B, C and D) after intracranial pressure (ICP) sensor implantation. D-galactosamine at 0.3, 0.25, 0.20 + 0.05 (24 h interval), and 0.20 g/kg body weight, respectively, was injected via the small saphenous vein. Vital signs, ICP, biochemical indices, and inflammatory factors were recorded at 0, 12, 24, 36, 48, 72, 96, and 120 h after D-galactosamine administration...
November 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29198612/il-1-family-cytokines-in-cardiovascular-disease
#5
Susanne Pfeiler, Holger Winkels, Malte Kelm, Norbert Gerdes
The interleukin (IL)-1 family is a group of cytokines crucially involved in regulating immune responses to infectious challenges and sterile insults. The family consists of the eponymous pair IL-1α and IL-1β, IL-18, IL-33, IL-37, IL-38, and several isoforms of IL-36. In addition, two endogenous inhibitors of functional receptor binding, IL-1R antagonist (IL-1Ra) and IL-36Ra complete the family. To gain biological activity IL-1β and IL-18 require processing by the protease caspase-1 which is associated with the multi-protein complex inflammasome...
November 30, 2017: Cytokine
https://www.readbyqxmd.com/read/29195025/lack-of-additional-effects-of-long-term-low-dose-clarithromycin-combined-treatment-compared-with-topical-steroids-alone-for-chronic-rhinosinusitis-in-china-a-randomized-controlled-trial
#6
Jie Deng, Fenghong Chen, YinYan Lai, Qing Luo, Rui Xu, Chunquan Ou, Qingling Fu, Jianbo Shi
BACKGROUND: In China, clarithromycin is considered an effective treatment option for chronic rhinosinusitis (CRS) due to its unique immunopathologic characteristics. Our study's aim was to determine whether a topical steroid and clarithromycin combination is better than a single topical steroid for Chinese patients with CRS. METHODS: Patients with CRS with/without nasal polyps were included in this study and randomly assigned to a clarithromycin plus budesonide aqua nasal spray group (CLM + BUD, clarithromycin 0...
November 30, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29193575/ethanol-mediated-suppression-of-il-37-licenses-alcoholic-liver-disease
#7
Felix Grabherr, Christoph Grander, Timon E Adolph, Verena Wieser, Lisa Mayr, Barbara Enrich, Sophie Macheiner, Moris Sangineto, Andreas Reiter, Andre Viveiros, Heinz Zoller, Philip Bufler, Alexander R Moschen, Charles A Dinarello, Herbert Tilg
BACKGROUND & AIMS: Chronic alcohol consumption and alcoholic liver disease (ALD) afflicts individuals with substantial morbidity and mortality with limited treatment options available. Hepatic inflammation, triggered by activated Kupffer cells, is a driving force in alcoholic liver disease. Interleukin 37 (IL-37) exerts anti-inflammatory effects in hepatic diseases, however the impact of Interleukin 37 on alcoholic liver disease is unknown. In this study, we addressed the role of Interleukin 37 in alcoholic liver disease...
November 29, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29191921/selective-egfr-epidermal-growth-factor-receptor-deletion-in-myeloid-cells-limits-atherosclerosis
#8
Lynda Zeboudj, Andréas Giraud, Lea Guyonnet, Yujiao Zhang, Ludivine Laurans, Bruno Esposito, Jose Vilar, Anna Chipont, Nikolina Papac-Milicevic, Christoph J Binder, Alain Tedgui, Ziad Mallat, Pierre-Louis Tharaux, Hafid Ait-Oufella
OBJECTIVE: To determine the consequences of specific inhibition of EGFR (epidermal growth factor receptor) in myeloid cells in atherosclerosis development. APPROACH AND RESULTS: Atherosclerotic lesion size was significantly reduced in irradiated Ldlr-/- mice reconstituted with LysMCre+Egfrlox/lox bone marrow, compared with chimeric Ldlr-/- mice reconstituted with LysMCre-Egfrlox/lox bone marrow, after 4 (-43%; P<0.05), 7 (-34%; P<0.05), and 12 weeks (-54%; P<0...
November 30, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29186830/the-genetic-basis-of-psoriasis
#9
REVIEW
Francesca Capon
Psoriasis is widely regarded as a multifactorial condition which is caused by the interaction between inherited susceptibility alleles and environmental triggers. In the last decade, technological advances have enabled substantial progress in the understanding of disease genetics. Genome-wide association studies have identified more than 60 disease susceptibility regions, highlighting the pathogenic involvement of genes related to Th17 cell activation. This pathway has now been targeted by a new generation of biologics that have shown great efficacy in clinical trials...
November 25, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29180446/quantitative-ligand-and-receptor-binding-studies-reveal-the-mechanism-of-interleukin-36-il-36-pathway-activation
#10
Li Zhou, Viktor Todorovic, Steve Kakavas, Bernhard Sielaff, Limary Medina, Leyu Wang, Ramkrishna Sadhukhan, Henning Stockmann, Paul L Richardson, Enrico DiGiammarino, Chaohong Sun, Victoria Scott
IL-36 cytokines signal through the IL-36 re-ceptor (IL-36R) and a shared subunit, IL-1 receptor accessory protein (IL-1RAcP). The activation mechanism for the IL-36 pathway is proposed to be similar to that of IL-1 in that an IL-36R agonist (IL-36α, IL-36β, or IL-36γ) forms a binary complex with IL-36R, which then recruits IL-1RAcP. Recent studies have shown that IL-36R interacts with IL-1RAcP even in the absence of an agonist. To elucidate the IL-36 activation mechanism, we considered all possible binding events for IL-36 ligands/receptors and examined these events in direct binding assays...
November 27, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29180005/leisure-time-physical-activity-across-adulthood-and-biomarkers-of-cardiovascular-disease-at-age-60-64-a-prospective-cohort-study
#11
Ahmed Elhakeem, Emily T Murray, Rachel Cooper, Diana Kuh, Peter Whincup, Rebecca Hardy
BACKGROUND AND AIMS: This study examined associations between leisure-time physical activity (LTPA) across adulthood (from age 36) and cardiovascular disease (CVD) biomarkers at age 60-64. METHODS: LTPA was reported by study participants from the MRC National Survey of Health and Development at ages 36, 43, 53 and 60-64 (n = 1754) and categorised as inactive, moderately active (1-4/month) or most active (5+/month) at each age. Linear regression was used to examine associations between a cumulative adulthood LTPA score (range = 0-8), and change in LTPA between ages 36 and 60-64 (i...
November 20, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29176319/e3-ubiquitin-ligase-rnf125-activates-interleukin-36-receptor-signaling-and-contributes-to-its-turnover
#12
Siddhartha S Saha, Gary Caviness, Guanghui Yi, Ernest L Raymond, M Lamine Mbow, C Cheng Kao
Signaling by the interleukin-36 receptor (IL-36R) is linked to inflammatory diseases such as psoriasis. However, the regulation of IL-36R signaling is poorly understood. Activation of IL-36R signaling in cultured cells results in an increased polyubiquitination of the receptor subunit, IL-1Rrp2. Treatment with deubiquitinases shows that the receptor subunit of IL-36R, IL-1Rrp2, is primarily polyubiquitinated at the K63 position, which is associated with endocytic trafficking and signal transduction. A minor amount of ubiquitination is at the K48 position that is associated with protein degradation...
November 25, 2017: Journal of Innate Immunity
https://www.readbyqxmd.com/read/29171983/growth-differentiation-factor-gdf-15-concentration-combined-with-ca125-levels-in-serum-is-superior-to-commonly-used-cancer-biomarkers-in-differentiation-of-pancreatic-mass
#13
Piotr Hogendorf, Adam Durczyński, Aleksander Skulimowski, Anna Kumor, Grażyna Poznańska, Janusz Strzelczyk
BACKGROUND: Pancreatic cancer (PDAC) will have been the second leading cancer-related death in the United States by 2020, according to current estimation. Its late manifestation and the lack of good early detection methods are the cause of extremely low survival rates. Therefore, there is an urgent need to develop highly sensitive and specific marker. GDF-15, a member of TGFbeta family, has recently emerged as a protein playing an important role in carcinogenesis of various neoplasms...
November 17, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/29168863/structure-characterization-of-a-novel-polysaccharide-from-hericium-erinaceus-fruiting-bodies-and-its-immunomodulatory-activities
#14
Fangfang Wu, Chunhui Zhou, Dandan Zhou, Shiyi Ou, Xiaoai Zhang, Huihua Huang
A novel polysaccharide fraction (HEP-S) was extracted and isolated from the fruiting bodies of Hericium erinaceus. Structural characterization revealed that HEP-S had an average molecular weight of 1.83 × 104 Da and consisted of rhamnose, fucose, mannose, glucose and galactose at a molar ratio of 1.47 : 0.93 : 1.36 : 8.68 : 4.08. Periodate oxidation-Smith degradation and NMR analysis showed that the main linkage types of HEP-S were composed of (1→)-α-d-Glc, (1→3,4)-α-d-Glc, (1→6)-α-d-Gal, (1→3,4)-β-d-Man, (1→3,6)-α-Rha and (1→2)-β-l-Fuc...
November 23, 2017: Food & Function
https://www.readbyqxmd.com/read/29168186/adipokines-and-inflammation-markers-and-risk-of-differentiated-thyroid-carcinoma-the-epic-study
#15
Laure Dossus, Silvia Franceschi, Carine Biessy, Anne-Sophie Navionis, Ruth C Travis, Elisabete Weiderpass, Augustin Scalbert, Isabelle Romieu, Anne Tjønneland, Anja Olsen, Kim Overvad, Marie-Christine Boutron-Ruault, Fabrice Bonnet, Agnès Fournier, Renee T Fortner, Rudolf Kaaks, Krasimira Aleksandrova, Antonia Trichopoulou, Carlo La Vecchia, Eleni Peppa, Rosario Tumino, Salvatore Panico, Domenico Palli, Claudia Agnoli, Paolo Vineis, Bas Bueno-de-Mesquita, Petra H Peeters, Guri Skeie, Raul Zamora-Ros, María-Dolores Chirlaque, Eva Ardanaz, Maria-Jose Sánchez, Jose Ramón Quirós, Miren Dorronsoro, Maria Sandström, Lena Maria Nilsson, Julie A Schmidt, Kay-Tee Khaw, Konstantinos K Tsilidis, Dagfinn Aune, Elio Riboli, Sabina Rinaldi
Other than the influence of ionizing radiation and benign thyroid disease, little is known about the risk factors for differentiated thyroid cancer (TC) which is an increasing common cancer worldwide. Consistent evidence shows that body mass is positively associated with TC risk. As excess weight is a state of chronic inflammation, we investigated the relationship between concentrations of leptin, adiponectin, C-reactive protein, interleukin(IL)-6, IL-10 and TNF-α and the risk of TC. A case-control study was nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) study and included 475 first primary incident TC cases (399 women and 76 men) and 1,016 matched cancer-free cohort participants...
November 23, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29166668/interleukin-36%C3%AE-and-il-36-receptor-signaling-mediate-impaired-host-immunity-and-lung-injury-in-cytotoxic-pseudomonas-aeruginosa-pulmonary-infection-role-of-prostaglandin-e2
#16
Tetsuji Aoyagi, Michael W Newstead, Xianying Zeng, Yuta Nanjo, Marc Peters-Golden, Mitsuo Kaku, Theodore J Standiford
Pseudomonas aeruginosa is a Gram-negative pathogen that can lead to severe infection associated with lung injury and high mortality. The interleukin (IL)-36 cytokines (IL-36α, IL-36β and IL-36γ) are newly described IL-1 like family cytokines that promote inflammatory response via binding to the IL-36 receptor (IL-36R). Here we investigated the functional role of IL-36 cytokines in the modulating of innate immune response against P. aeruginosa pulmonary infection. The intratracheal administration of flagellated cytotoxic P...
November 22, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/29163429/relationship-between-gingival-crevicular-fluid-microbiota-and-cytokine-profile-in-periodontal-host-homeostasis
#17
Jianye Zhou, Yiqing Yao, Kangli Jiao, Jumei Zhang, Xin Zheng, Fang Wu, Xiaopan Hu, Junping Li, Zhanhai Yu, Gaosen Zhang, Nan Jiang, Zhiqiang Li
As potential biomarkers in periodontitis, microbiome, and cytokines have recently been extensively investigated, but combined analyses of the variations between the microbial structure and cytokine composition are rare. The present study aimed to investigate whether there are differences in the combined profile of microbiome and cytokines in individuals with or without periodontitis. The microbiome and cytokine composition in gingival crevicular fluid (GCF) from 16 patients and 15 controls from Jishi Shan (Gansu, China) were analyzed using 454 pyrosequencing and RayBio Quantibody Arrays...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29142375/the-effects-of-atorvastatin-on-inflammatory-responses-and-mortality-in-septic-shock-a-single-center-randomized-controlled-trial
#18
Ratender Kumar Singh, Vikas Agarwal, Arvind Kumar Baronia, Sudeep Kumar, Banani Poddar, Afzal Azim
Aim of the Study: Pleiotropic effect of statins can modulate inflammation in septic shock. We tested the hypothesis whether statins can reduce mortality in septic shock. Patients and Methods: We conducted a randomized double-blinded trial with treatment (40 mg dose of atorvastatin for 7 days) and control (placebo) arm in adult septic shock patients admitted to the Intensive Care Unit. Primary (28-day mortality) and secondary (vasopressor-, ventilation-, and renal replacement therapy-free days) outcomes, with lipid profile and adverse effects, were documented...
October 2017: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/29141125/elevated-proinflammatory-markers-in-22q11-2-deletion-syndrome-are-associated-with-psychosis-and-cognitive-deficits
#19
Ehud Mekori-Domachevsky, Michal Taler, Yehuda Shoenfeld, Michael Gurevich, Polina Sonis, Omri Weisman, Abraham Weizman, Doron Gothelf
OBJECTIVE: 22q11.2 deletion syndrome (22q11.2DS) is a neurogenetic disorder whose phenotype includes high rates of a schizophrenia-like psychotic disorder and immune system abnormalities. Thus, 22q11.2DS is an ideal model for studying the relationship between psychosis and inflammation. The aim of the present study was to identify inflammatory markers that may play a role in the pathophysiologic pathways associated with psychosis and cognitive deficits in 22q11.2DS. METHODS: Forty-nine individuals with 22q11...
November 14, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29138816/protective-effects-of-fucoidan-against-hyperoxic-lung-injury-via-the-erk-signaling-pathway
#20
Minghao Nie, Yan Wang, Yanhong Lu, Ying Yuan, Yingying Liu, Xiurong Li
High oxygen mechanical ventilation is widely used to treat various lung diseases; however, it may result in hyperoxia, which induces inflammation and lung injury. Fucoidan is an extract of the seaweed Fucus vesiculosus, which has previously been reported to exert effects against diabetic nephropathy. The present study is the first, to the best of our knowledge, to investigate the protective effects of fucoidan against hyperoxic lung injury. Balb/c mice were ventilated with 100% oxygen, with or without the atomization inhalation of fucoidan, for 36 h...
November 10, 2017: Molecular Medicine Reports
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