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Interleukin 36

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https://www.readbyqxmd.com/read/27926540/the-novel-interleukin-1-cytokine-family-members-in-inflammatory-diseases
#1
Madelaine Hahn, Silke Frey, Axel J Hueber
PURPOSE OF REVIEW: This review provides an update on the new interleukin-1 (IL-1) cytokine family members in inflammatory diseases with focus on recent findings concerning the family members IL-36, IL-37, and IL-38 and their different expression patterns. RECENT FINDINGS: The IL-1 cytokines are known to be involved in many different inflammatory and autoimmune diseases. The latest IL-1 family members, IL-36, IL-37, and IL-38 have been shown to be differently regulated during course of disease...
December 6, 2016: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/27918832/the-effect-of-ambient-titanium-dioxide-microparticle-exposure-to-the-ocular-surface-on-the-expression-of-inflammatory-cytokines-in-the-eye-and-cervical-lymph-nodes
#2
Youngsub Eom, Jong Suk Song, Hyun Kyu Lee, Boram Kang, Hyeon Chang Kim, Hyung Keun Lee, Hyo Myung Kim
Purpose: To investigate the ocular immune response following exposure to airborne titanium dioxide (TiO2) microparticles. Methods: Rats in the TiO2-exposed group (n = 10) were exposed to TiO2 particles for 2 hours twice daily for 5 days, while the controls (n = 10) were not. Corneal staining score and tear lactic dehydrogenase (LDH) activity were measured to evaluate ocular surface damage, serum immunoglobulin (Ig) G and E were assayed by using enzyme-linked immunosorbent assay, and the size of cervical lymph nodes was measured...
December 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27918732/relationship-between-889-c-t-polymorphism-in-interleukin-1a-gene-and-risk-of-chronic-periodontitis-evidence-from-a-meta-analysis-with-new-published-findings
#3
F-R-P da Silva, A-C-C Guimarães-Vasconcelos, L-F de-Carvalho-França, D di-Lenardo, L-S Rodrigues, M-L-L Barreto-do-Nascimento, D-F-P Vasconcelos
BACKGROUND: Periodontitis results from an inflammatory response caused by accumulative microorganisms in periodontal sites. Several factors are involved in pathogenesis of periodontitis, for example the -889 C/T polymorphism in interleukin-1A gene. This study aimed to evaluate the relationship between this polymorphism and risk of development of chronic periodontitis by a meta-analysis based in new published findings. MATERIAL AND METHODS: Thereunto a review in literature was performed in the electronic biomedical and education databases (Cochrane Library, Google Scholar, MEDLINE and PubMed) to studies published before August 2, 2015, the abstracts were evaluated and the data extraction performed by two calibrated examiners...
December 6, 2016: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/27916079/-role-and-mechanism-of-th17-treg-in-obstructive-sleep-apnea-hypopnea-syndrome
#4
Y Liu, Y C Gu, Y Tang, X L Lü, H Chen, Q Z Wu
Objective: To explore the role and the mechanism of Th17/Treg in obstructive sleep apnea hypopnea syndrome (OSAHS). Methods: A total of 100 patients who completed polysomnography (PSG) in the sleep lab of Affiliated Wujiang Hospital of Nantong University from Mar. 2015 to Apr. 2016 were enrolled and divided into four groups (primary snoring as the control group, mild OSAHS, moderate OSAHS and severe OSAHS) according apnea hypopnea index (AHI). The proportion of Th17, Treg (of CD4(+) T cells) and the expression of interleukin (IL)-17A, IL-6 were detected and the relevant data were analyzed by the correlation analysis and the multiple stepwise regression analysis...
November 29, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/27904530/blockade-of-il-23-ameliorates-allergic-lung-inflammation-via-decreasing-the-infiltration-of-tc17-cells
#5
Sheng Cheng, Huilong Chen, Aili Wang, Hansvin Bunjhoo, Yong Cao, Jungang Xie, Yongjian Xu, Weining Xiong
INTRODUCTION: Tc17 cells are interleukin (IL)-17-producing CD8(+) T cells and have been found to participate in the development of allergic asthma. Interleukin-23 is a cytokine that may be involved in modulating the IL-17 response via Th17 cells. This study aimed to investigate whether IL-23 also has immunomodulatory effects on Tc17 cells. MATERIAL AND METHODS: An allergic asthmatic mouse model was induced by sensitizing and challenging with ovalbumin (OVA). Anti-IL-23 antibody was administered intratracheally before challenge to the OVA-induced asthmatic mouse model...
December 1, 2016: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/27896585/effect-of-an-herbal-mixture-of-cinnamon-cortex-persicae-semen-and-natril-sulfas-on-collagen-induced-arthritis-and-lipopolysaccharides-induced-nuclear-factor-%C3%AE%C2%BA-b-signaling
#6
Ji-Won Lee, Jae-Hwan Lew, Tae-Woo Kim, Hee Kang
OBJECTIVE: To investigate the anti-arthritic and anti-inflammatory effects of the mixture of three herbal agents, Cinnamon Cortex, Persica Semen, and Natril Sulfas (CPN), the major ingredients of Taoren Chengqi Decoction (). METHODS: Collagen-induced arthritis (CIA) was induced by immunization with bovine type II collagen on day 1 and 21. DBA/1J mice were orally administered the water extract of CPN (100 and 500 mg/kg) and indomethacin (1 mg/kg) or vehicle (water) 3 times per week for 6 weeks...
November 17, 2016: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/27876639/behavioral-changes-in-male-mice-fed-a-high-fat-diet-are-associated-with-il-1%C3%AE-expression-in-specific-brain-regions
#7
Camila P Almeida-Suhett, Alice Graham, Yifan Chen, Patricia Deuster
High-fat diet (HFD)-induced obesity is associated with not only increased risk of metabolic and cardiovascular diseases, but cognitive deficit, depression and anxiety disorders. Obesity also leads to low-grade peripheral inflammation, which plays a major role in the development of metabolic alterations. Previous studies suggest that obesity-associated central inflammation may underlie the development of neuropsychiatric deficits, but further research is needed to clarify this relationship. We used 36 male C57BL/6J mice to investigate whether chronic consumption of a high-fat diet leads to increased expression of interleukin-1β (IL-1β) in the hippocampus, amygdala and frontal cortex...
November 19, 2016: Physiology & Behavior
https://www.readbyqxmd.com/read/27876112/antioxidant-defense-of-nrf2-vs-pro-inflammatory-system-of-nf-%C3%AE%C2%BAb-during-the-amoebic-liver-infection-in-hamster
#8
Liseth R Aldaba-Muruato, Martin H Muñoz-Ortega, María Del R Campos-Esparza, José R Macías-Pérez, Nayeli A Márquez-Muñoz, Ana G Villalobos-Santos, Javier Ventura-Juárez
Entamoeba histolytica is the causative agent of amoebic liver abscess (ALA), which course with an uncontrolled inflammation and nitro-oxidative stresses, although it is well known that amoeba has an effective defence mechanisms against this toxic environment, the underlying molecular factors responsible for progression of tissue damage remain largely unknown. The purpose of the present study was to determine during the acute stage of ALA in hamsters, the involvement of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) and nuclear factor-kappa B (NF-κB), which are activated in response to oxidative stress...
November 23, 2016: Parasitology
https://www.readbyqxmd.com/read/27869741/isoliquiritigenin-attenuates-atherogenesis-in-apolipoprotein-e-deficient-mice
#9
Fen Du, Quzhen Gesang, Jia Cao, Mei Qian, Li Ma, Dongfang Wu, Hong Yu
Isoliquiritigenin (ISL) exhibits antioxidation and anti-inflammation activity. We sought to investigate the effects and mechanism of ISL on the development of atherosclerotic lesions in apolipoprotein E-deficient (apoE(-/-)) mice. Firstly, we determined that ISL reduced the mRNA levels of inflammatory factors interleukin 6 (IL-6), tumor necrosis factor α (TNF-α), and monocyte chemotactic protein-1 (MCP-1), while it increased the expression of several lipoprotein-related genes in peritoneal macrophages treated with lipopolysaccharide (LPS)...
November 18, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27869736/circulating-il-27-is-elevated-in-rheumatoid-arthritis-patients
#10
Xiaofei Lai, Hongxu Wang, Ju Cao, Ying Li, Yubing Dai, Yu Xiang, Liping Zhang
Cytokines are key immunoregulatory molecules that regulate T lymphocyte-mediated immune responses and inflammatory reactions. We determined whether there is aberrant expression of interleukin-27 (IL-27) in rheumatoid arthritis (RA) patients and investigated the clinical significance of these changes. IL-27 is a key cellular factor that regulates the differentiation of CD4+ T cells, which can secrete interleukin-10 (IL-10) and interleukin-17 (IL-17) in vivo. Concentrations of serum IL-27 in 67 RA patients, and 36 sex- and age-matched control subjects were measured by enzyme-linked immunosorbent assay (ELISA)...
November 18, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27866993/micrornas-223-3p-and-93-5p-in-patients-with-chronic-kidney-disease-before-and-after-renal-transplantation
#11
M Ulbing, A H Kirsch, B Leber, S Lemesch, J Münzker, N Schweighofer, D Hofer, O Trummer, A R Rosenkranz, H Müller, K Eller, V Stadlbauer, B Obermayer-Pietsch
Chronic kidney disease (CKD) is associated with a multifactorial dysregulation of bone and vascular calcification and closely linked to increased cardiovascular mortality and concomitant bone disease. We aimed to investigate specific microRNA (miRNA) signatures in CKD patients to find indicators for vascular calcification and/or bone mineralization changes during CKD and after kidney transplantation (KT). A miRNA array was used to investigate serum miRNA profiles in CKD patients, then selected miRNAs were quantified in a validation cohort comprising 73 patients in CKD stages 3 to 5, 67 CKD patients after KT, and 36 healthy controls...
November 17, 2016: Bone
https://www.readbyqxmd.com/read/27862977/low-dose-il-2-increase-regulatory-t-cells-and-elevate-platelets-in-a-patient-with-immune-thrombocytopenia
#12
Jiakui Zhang, Yanjie Ruan, Yuanyuan Shen, Qianshan Tao, Huiping Wang, Lili Tao, Yin Pan, Huizi Fang, Yiping Wang, Zhimin Zhai
Immune thrombocytopenia (ITP) is an autoimmune disorder in which its immune system destroy platelets and lead to haemorrhage symptom. Recent studies have found that regulatory T cells (Tregs) in peripheral blood, bone marrow, and spleen were reduced in ITP patients and recovered after effective ITP therapy. Low-dose Interleukin-2 (IL-2) has been reported recently to increase Tregs and used to treat autoimmune disease including graft-versus-host disease (GVHD) after organ transplantation and HCV-related autoimmune vasculitis...
November 9, 2016: Cytometry. Part B, Clinical Cytometry
https://www.readbyqxmd.com/read/27858863/is-adjunctive-treatment-with-medication-of-liver-soothing-oriented-method-beneficial-for-depression-after-cerebrovascular-accident-a-prisma-compliant-meta-analysis
#13
Ling-Feng Zeng, Wei-Xiong Liang, Jia-Ci Liu, Xiao-Yan Chen, Wen-Yi Du, Zi-Ping Li, Qi Wang, Ye Cao, Lu Wang, Chang-Rong Meng, Ke-Zhu Wang, Ning-Sheng Wang
BACKGROUND: Adjunctive treatment with medication of liver-soothing-oriented method (MLSM) is one of the most commonly used approaches for subjects with depression after cerebrovascular accident (DCVA) in China. The purpose of this meta-analysis was to evaluate the outcome of MLSM treatment in subjects with DCVA using relevant published literature. METHODS: The PubMed, Cochrane Library, Embase, Chinese databases of China National Knowledge Infrastructure, WanFang, Sinomed, and VIP were used to collect all publications until March 2016...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27855589/twice-daily-telaprevir-for-posttransplant-genotype-1-hepatitis-c-virus-a-prospective-safety-efficacy-and-pharmacokinetics-study
#14
Raymond A Rubin, Mark W Russo, Kimberly A Brown, Robert J Fontana, Josh Levitsky, Hugo Vargas, Eric M Yoshida, Robert S Brown
OBJECTIVES: Our objective was to determine the safety, efficacy, and pharmacokinetics of telaprevir plus pegylated interferon alfa 2a and ribavirin for chronic, posttransplant genotype 1 hepatitis C virus infection. MATERIALS AND METHODS: A prospective, single-arm, multicenter, open-label, phase 2b study was conducted at 22 North American sites to assess the safety, efficacy, and pharmacokinetics of pegylated interferon alfa 2a, ribavirin, and twice daily telaprevir in liver transplant recipients with recurrent, chronic hepatitis C without cirrhosis...
November 18, 2016: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/27845395/slow-reduction-of-ip-10-levels-predicts-hbeag-seroconversion-in-chronic-hepatitis-b-patients-with-5-years-of-entecavir-treatment
#15
Renyong Guo, Hejun Mao, Xiao Hu, Nengneng Zheng, Dong Yan, Jianqin He, Jiezuan Yang
The aim of this study was to determine the correlation between dynamic changes in serum cytokine/chemokine expression levels in response to entecavir (ETV) treatment and HBV e antigen (HBeAg) seroconversion in patients with chronic hepatitis B (CHB). Four cytokines (interleukin [IL]-4, IL-6, IL-8, and interferon-γ) and five chemokines (macro-phage inflammatory protein [MIP]-1α, MIP-1β, platelet derived growth factor-BB, and interferon-inducible protein 10 [IP-10]) before ETV therapy and at 3, 6, 12, 24, 36 and 60 months during therapy in 105 CHB patients were analyzed...
November 15, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27836181/circadian-preferences-oxidative-stress-and-inflammatory-cytokines-in-bipolar-disorder-a-community-study
#16
Thaise Campos Mondin, Taiane de Azevedo Cardoso, Fernada Pedrotti Moreira, Carolina Wiener, Jean Pierre Oses, Luciano Dias de Mattos Souza, Karen Jansen, Pedro Vieira da Silva Magalhães, Flávio Kapczinski, Ricardo Azevedo da Silva
OBJECTIVE: To assess circadian preference among a community sample of people with bipolar disorder, major depression and without any mood disorders. Secondly, we investigated the association of circadian preference with cytokines interleukin-6 (IL-6), interleukin-10 (IL-10) and, tumor necrosis factor alpha (TNF-α) and oxidative stress assessed by thiobarbituric acid reactive substances (TBARS), uric acid and Protein Carbonyl Content (PCC). METHOD: A cross-sectional study nested in a population-based sample...
November 4, 2016: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/27833481/cardiac-and-renal-protective-effects-of-dexmedetomidine-in-cardiac-surgeries-a-randomized-controlled-trial
#17
A S Ammar, K M Mahmoud, Z A Kasemy, M A Helwa
BACKGROUND: Cardiac and renal injuries are common insults after cardiac surgeries that contribute to perioperative morbidity and mortality. Dexmedetomidine has been shown to protect several organs against ischemia/reperfusion-(I/R) induced injury. We performed a randomized controlled trial to assess the effect of dexmedetomidine on cardiac and renal I/R injury in patients undergoing cardiac surgeries. MATERIALS AND METHODS: Fifty patients scheduled for elective cardiac surgeries were randomized to dexmedetomidine group that received a continuous infusion of dexmedetomidine initiated 5 min before cardiopulmonary bypass (1 μg/kg over 15 min, followed by 0...
October 2016: Saudi Journal of Anaesthesia
https://www.readbyqxmd.com/read/27832827/human-brain-chemokine-and-cytokine-expression-in-sepsis-a-report-of-three-cases
#18
Jordan Warford, Anna-Claire Lamport, Barry Kennedy, Alexander S Easton
BACKGROUND: Sepsis is a systemic response to infection that can affect brain function by inducing resident cells (including astrocytes and microglia) to generate brain chemokines and cytokines. However, there are few studies on the human brain. Since this information may shed further light on pathogenesis, our study objective was to measure the expression of 36 chemokines and cytokines in autopsied brain from 3 cases of sepsis and 10 controls, and to relate this to astrocyte and microglial activation...
November 11, 2016: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://www.readbyqxmd.com/read/27832441/comparative-effect-of-the-i3-1-probiotic-formula-in-two-animal-models-of-colitis
#19
Violeta Lorén, Josep Manyé, Mari C Fuentes, Eduard Cabré, Isabel Ojanguren, Jordi Espadaler
Use of probiotic therapy is an active area of investigation to treat intestinal disorders. The clinical benefits of the I3.1 probiotic formula (Lactobacillus plantarum (CECT7484, CECT7485) and P. acidilactici (CECT7483)) were demonstrated in irritable bowel syndrome (IBS) patients in a randomized, double-blind, placebo-controlled clinical trial. The aim of this study was to evaluate the therapeutic effects of I3.1 in two experimental models of colitis, a dextran sulfate sodium (DSS)-induced colitis model and an interleukin (IL)-10-deficient mice model...
November 10, 2016: Probiotics and Antimicrobial Proteins
https://www.readbyqxmd.com/read/27831647/the-clinical-significance-of-level-changes-of-hs-crp-il-10-and-tnf-for-patients-with-ms-during-active-and-relieving-period
#20
A-L Ji, Z-H Liu, W-W Chen, W-J Huang
OBJECTIVE: To investigate the clinical significance of the change of the level of hs-CRP, interleukin-10 (IL-10) and tumor necrosis factors (TNF-α) for patients with multiple sclerosis (MS) during the active and the relieving period. PATIENTS AND METHODS: 36 patients with MS during the active stage and the relieving stage after therapy (experimental group) were compared with 10 healthy people at the relieving period, considered as control group. Immunoturbidimetry was used to examine levels of hs-CRP while the level of IL-10 and TNF-a were tested by enzyme-linked immunosorbent assay (ELISA)...
October 2016: European Review for Medical and Pharmacological Sciences
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