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Interleukin 36

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https://www.readbyqxmd.com/read/29036979/-role-of-ash2-absent-small-or-homeotic-like-and-jumonji-domain-containing-protein-3-on-histone-methylation-of-interferon-gamma-gene-and-their-associations-with-vascular-damage-of-kawasaki-disease
#1
J H Mei, G Tang, Q Wang, P Q Wen, M G Xu, D Cui, D L Ma, C Liu, G B Wang
Objective: To investigate the impacts of ash2 (absent, small, or homeotic)-like (Ash2L) and Jumonji domain-containing protein 3 (Jmjd3) on histone methylation of interferon-gamma(IFN-γ) gene and association with vascular damage of Kawasaki disease (KD) in acute phase. Methods: This study was performed among 36 children with KD in acute phase (KD group) and 28 age-matched health children (control group), who were treated or underwent physical examination in our hospital between February 2015 and June 2016. Patients were further divided into KD groups with or without coronary artery lesions (KD-CAL(+) , 16 cases; KD-CAL(-), 20 cases)...
September 24, 2017: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/29036956/-the-diagnostic-value-of-neuron-specific-enolase-central-nervous-system-specific-protein-and-interleukin-6-in-sepsis-associated-encephalopathy
#2
Q Feng, L Wu, Y H Ai, S Y Deng, M L Ai, L Huang, Z Y Liu, L N Zhang
Objective: To investigate the diagnostic value of neuron-specific enolase(NSE), central nervous system specific protein(S100β), interleukin-6(IL-6) in sepsis-associated encephalopathy(SAE). Methods: Clinical data of patients admitted to ICU and diagnosed with sepsis were collected from January 2015 to June 2016 in Xiangya Hospital, Central South University. SAE was defined as cerebral dysfunction in the presence of sepsis that also fulfilled the exclusion criteria. The acute physiology and chronic health score (APACHE Ⅱ), sequential organ failure assessment (SOFA), NSE, S100β, IL-6, ICU stay time and 28-day mortality were compared between the two groups...
October 1, 2017: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/29033107/soluble-urokinase-type-plasminogen-activator-receptor-supar-and-interleukin-6-levels-in-hyperemesis-gravidarum
#3
Raziye Desdicioglu, Melahat Yildirim, Gulcan Kocaoglu, Busra Demir Cendek, Gamze Avcioglu, Emre Erdem Tas, Ozlem Sengul, Ozcan Erel, Ayse Filiz Yavuz
BACKGROUND: The aim was to compare serum soluble urokinase-type plasminogen activator receptor (suPAR) levels as well as interleukin-6 levels (IL-6) in pregnant women with hyperemesis gravidarum (HG) and asymptomatic pregnant women. METHODS: Our study population consists of voluntary first trimester-pregnant women who applied to the outpatient clinic of the department of obstetrics and gynecology of Ankara Ataturk Training and Research Hospital. Between February and May 2016, 60 pregnant women were included in our prospective study...
October 9, 2017: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/29029524/comparative-efficacy-and-safety-of-antibody-induction-therapy-for-the-treatment-of-kidney-a-network-meta-analysis
#4
Mingjie Shao, Tingting Tian, Xinyan Zhu, Yingzi Ming, Yasuko Iwakiri, Shaojun Ye, Qifa Ye
To evaluate the efficacy and safety of antibody induction therapies in kidney transplantation. Systematic literature searches were undertaken using MEDLINE, Embase, and Cochrane Library database from 1980 to 2016. Randomized controlled trials (RCTs) comparing three antibody induction therapies (alemtuzumab, interleukin-2 receptor antibodies and antithymocyte globulin) between each other were identified. Bayesian network meta-analysis was used to combine both the direct and indirect evidence on treatment efficacy and its safety...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29026717/addition-of-interleukin-6-to-mouse-embryo-culture-increases-blastocyst-cell-number-and-influences-the-inner-cell-mass-to-trophectoderm-ratio
#5
Rebecca L Kelley, David K Gardner
OBJECTIVE: In vitro culture of preimplantation embryos is improved by grouping embryos together in a drop of media. Individually cultured embryos are deprived of paracrine factors; with this in mind, we investigated whether the addition of a single embryo-secreted factor, interleukin-6 (IL-6), could improve the development of individually cultured embryos. METHODS: Mouse embryos were cultured individually in 2 µL of G1/G2 media in 5% oxygen and supplemented with a range of doses of recombinant mouse or human IL-6...
September 2017: Clinical and Experimental Reproductive Medicine
https://www.readbyqxmd.com/read/29021408/repeat-syphilis-has-a-different-immune-response-compared-with-initial-syphilis-an-analysis-of-biomarker-kinetics-in-two-cohorts
#6
Chris Kenyon, Achilleas Tsoumanis, Kara Osbak, Marjan Van Esbroeck, Eric Florence, Tania Crucitti, Luc Kesten
OBJECTIVE: We aimed to asses if there are differences in the clinical presentation and immune response of repeat as compared with initial syphilis. METHODS: Prospective study: we prospectively recruited all patients with a new diagnosis of syphilis and tested their plasma for a range of cytochemokines and rapid plasma reagin (RPR) at baseline pretreatment and 6 months following therapy. Retrospective study: we compared RPR assay response kinetics between initial and repeat syphilis in persons attending our HIV/STI clinic from 1993 to 2016...
October 11, 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/29021166/an-analysis-of-il-36-signature-genes-and-individuals-with-il1rl2-knockout-mutations-validates-il-36-as-a-psoriasis-therapeutic-target
#7
Satveer K Mahil, Marika Catapano, Paola Di Meglio, Nick Dand, Helena Ahlfors, Ian M Carr, Catherine H Smith, Richard C Trembath, Mark Peakman, John Wright, Francesca D Ciccarelli, Jonathan N Barker, Francesca Capon
Interleukin (IL)-36α, IL-36β, and IL-36γ are innate mediators of acute epithelial inflammation. We sought to demonstrate that these cytokines are also required for the pathogenesis of plaque psoriasis, a common and chronic skin disorder, caused by abnormal T helper 17 (TH17) cell activation. To investigate this possibility, we first defined the genes that are induced by IL-36 cytokines in primary human keratinocytes. This enabled us to demonstrate a significant IL-36 signature among the transcripts that are up-regulated in plaque psoriasis and the susceptibility loci associated with the disease in genome-wide studies...
October 11, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/29017654/-therapeutic-effect-of-hesperidin-on-severe-acute-pancreatitis-in-rats-and-its-mechanism
#8
Min Li, Zhisong Guo, Huanzhang Shao, Bingyu Qin
OBJECTIVE: To investigate the protective effect of hesperidin on severe acute pancreatitis (SAP) in rats and its related mechanism. METHODS: Sixty male Sprague-Dawley (SD) rats were randomly divided into five groups (n = 12 in each group): sham group, SAP model group, dexamethasone group (5 mg/kg), low and high dose of hesperidin groups (10 mg/kg and 20 mg/kg). SAP rats were administered a retrograde infusion of 3.5% sodium taurocholate solution into the biliopancreatic duct after laparotomy...
October 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/28992387/a-nationwide-experience-with-the-off-label-use-of-interleukin-1-targeting-treatment-in-familial-mediterranean-fever-patients
#9
Servet Akar, Pınar Cetin, Umut Kalyoncu, Omer Karadag, Ismail Sari, Muhammed Cınar, Sedat Yilmaz, Ahmet Mesut Onat, Bunyamin Kisacik, Abdulsamet Erten, Ayse Balkarli, Orhan Kucuksahin, Sibel Yilmaz Oner, Soner Senel, Abdurrahman Tufan, Haner Direskeneli, Ferhat Oksuz, Yavuz Pehlivan, Ozun Bayindir, Gokhan Keser, Kenan Aksu, Ahmet Omma, Timucin Kasifoglu, Ali Ugur Unal, Fatih Yildiz, Mehmet Ali Balci, Sule Yavuz, Sukran Erten, Metin Ozgen, Mehmet Sayarlıoglu, Atalay Dogru, Gozde Yildirim, Fatma Alibaz Oner, Mehmet Engin Tezcan, Omer Nuri Pamuk, Fatos Onen
OBJECTIVE: Around 30-45% of patients with familial Mediterranean fever (FMF) have been reported to have attacks despite colchicine treatment. Currently, data on the treatment of colchicine-unresponsive or colchicine-intolerant FMF patients are limited; the most promising alternatives seem to be anti-interleukin-1 (anit-IL1) agents. Herein we report our experience with the off-label use of anti-IL1 agents in a large group of FMF patients. METHODS: In all, 21 centers from different geographical regions of Turkey were included in the current study...
October 9, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28992341/a-prospective-study-of-inflammatory-markers-and-risk-of-endometriosis
#10
Fan Mu, Holly R Harris, Janet W Rich-Edwards, Susan E Hankinson, Eric B Rimm, Donna Spiegelman, Stacey A Missmer
A body of evidence suggests a role for inflammation in the pathogenesis of endometriosis. Numerous case-control studies have found that inflammatory markers were elevated in endometriosis cases compared to controls. However, results are not consistent and no prior prospective study exists. We conducted a case-control study study nested within the Nurses' Health Study II examining the associations between plasma levels of interleukin-1 beta (IL-1ß), IL-6, soluble tumor necrosis factor α receptor-1 (sTNFR-1), sTNFR-2, and high-sensitivity C-reactive protein and laparoscopically-confirmed endometriosis risk...
July 13, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28990414/biomarkers-of-endothelial-renal-and-platelet-dysfunction-in-stage-5-chronic-kidney-disease-hemodialysis-patients-with-heart-failure
#11
Ryan McMillan, Leonidas Skiadopoulos, Debra Hoppensteadt, Nil Guler, Vinod Bansal, Ravipresenna Parasuraman, Jawed Fareed
The aim of this study was to determine the role of endothelial, renal, and inflammatory biomarkers in the pathogenesis of heart failure (HF) in patients with stage 5 chronic kidney disease (CKD5) undergoing maintenance hemodialysis (HD). Plasma levels of biomarkers-kidney injury molecule 1 (KIM-1), N-terminal pro brain natriuretic peptide (NT-proBNP), glycated hemoglobin, neutrophil gelatinase-associated lipocalin, interleukin-18,platelet-derived growth factor, platelet factor 4 (PF4), 25-OH vitamin D, parathyroid hormone (PTH), endothelin, and endocan-were measured in CKD5-HD patients at the Loyola University Ambulatory Dialysis facility...
January 1, 2017: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/28988898/elevated-aqueous-cytokine-levels-in-eyes-with-ocular-surface-diseases
#12
Naohiko Aketa, Takefumi Yamaguchi, Teru Asato, Yukari Yagi-Yaguchi, Terumasa Suzuki, Kazunari Higa, Toshihide Kurihara, Yoshiyuki Satake, Kazuo Tsubota, Jun Shimazaki
PURPOSE: To evaluate cytokine and protein levels in the aqueous humor (AqH) of eyes with ocular surface diseases. DESIGN: Prospective consecutive case series. METHODS: This study includes 14 patients (62.4±13.7 years old) with chronic-phase ocular surface diseases (4 with ocular cicatricial pemphigoid, 5 with chemical burns, 2 with a thermal burn, 2 with Stevens-Johnson syndrome, and 1 with exposure keratitis), 14 matched patients without ocular surface disease (controls with corneal scar) and 30 patients who underwent cataract surgery (healthy controls)...
October 5, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28987470/potential-therapeutic-impact-of-omega-3-long-chain-polyunsaturated-fatty-acids-on-inflammation-markers-in-duchenne-muscular-dystrophy-a-double-blind-controlled-randomized-trial
#13
Maricela Rodríguez-Cruz, Oriana Del Rocío Cruz-Guzmán, Tomás Almeida-Becerril, Alan Donovan Solís-Serna, Salvador Atilano-Miguel, Juan Raúl Sánchez-González, Lourdes Barbosa-Cortés, Eugenia Dolores Ruíz-Cruz, Juan Carlos Huicochea, Alan Cárdenas-Conejo, Rosa Elena Escobar-Cedillo, Carlos Alberto Yam-Ontiveros, Edgar F Ricárdez-Marcial
BACKGROUND & AIMS: Duchenne Muscular Dystrophy (DMD) is the most frequent dystrophy in childhood generated by a deficiency in dystrophin. DMD is a neuromuscular disease and its clinical course comprises chronic inflammation and gradual muscle weakness. Supplementation of omega-3 long chain-Polyunsaturated Fatty Acids (ω-3 long chain-PUFA) reduces inflammatory markers in various disorders. The goal of this research was to analyze the influence of ω-3 long chain-PUFA intake on gene expression and blood inflammatory markers in boys with DMD...
September 23, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28985770/systemic-inflammation-mediates-the-detrimental-effects-of-obesity-on-asthma-control
#14
X Zhang, J Zheng, L Zhang, Y Liu, G P Chen, H P Zhang, L Wang, D Y Kang, L G Wood, G Wang
BACKGROUND: Obesity negatively impacts asthma control, but the inflammatory mechanisms are poorly understood. OBJECTIVE: To explore which systemic inflammatory mediators mediate the effects of obesity on asthma control. METHODS: The subjects with stable asthma (n = 108) underwent assessment of clinical characteristics, which included usingThe Asthma Control Questionnaire (ACQ)-6. Obesity was defined as a body mass index (BMI) of more than or equal to 30 kg/m2, overweight was defined as BMI between 25 to 29...
October 2, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28978347/clinical-features-of-igg4-related-periaortitis-periarteritis-based-on-the-analysis-of-179-patients-with-igg4-related-disease-a-case-control-study
#15
Makiko Ozawa, Yasunari Fujinaga, Junpei Asano, Akira Nakamura, Takayuki Watanabe, Tetsuya Ito, Takashi Muraki, Hideaki Hamano, Shigeyuki Kawa
BACKGROUND: Immunoglobulin G4-related disease (IgG4-RD) is a newly recognized systemic condition characterized by high serum immunoglobulin G4 (IgG4) concentration and IgG4-bearing plasma cell infiltration in affected organs. Although it has become evident that IgG4-RD also involves the systemic aortic/arterial system, the precise details of this condition remain unclear. The present study sought to clarify the clinical features of IgG4-related periaortitis/periarteritis. METHODS: Among 223 patients with IgG4-RD, 179 (131 male, median onset age 67 years) were recruited for this study...
October 4, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28975821/normokalemic-nondepolarizing-long-acting-blood-cardioplegia
#16
Amber Malhotra, Vivek Wadhawa, Jaydip Ramani, Pankaj Garg, Pranav Sharma, Himani Pandya, Dayesh Rodricks, Reema Tavar
Objective Blood cardioplegia, the gold-standard cardioprotective strategy, requires frequent dosing, resulting in hyperkalemia-induced myocardial edema. The aim of our study was to compare the efficacy and safety of a long-acting blood-based cardioplegia with physiological potassium levels versus the well-established cold blood St. Thomas' Hospital no. 1 cardioplegia solution in multivalve surgeries. Methods One hundred patients undergoing simultaneous elective aortic and mitral valve replacement ± tricuspid valve repair were randomized in two groups...
January 1, 2017: Asian Cardiovascular & Thoracic Annals
https://www.readbyqxmd.com/read/28975626/il-36-in-hidradenitis-suppurativa-evidence-for-a-distinctive-pro-inflammatory-role-and-a-key-factor-in-the-development-of-an-inflammatory-loop
#17
S Hessam, M Sand, T Gambichler, M Skrygan, I Rüddel, F G Bechara
BACKGROUND: A possible regulatory involvement of the interleukin (IL)-36 family in inflammatory diseases has been suggested. OBJECTIVES: To analyze the expression of IL-36α, β, γ, and the antagonistic cytokines IL-36Ra, IL-37, and IL38 in the skin of hidradenitis suppurativa (HS) patients. METHODS: Skin samples from lesional and corresponding perilesional HS skin, and from healthy controls were included in this study and analyzed by quantitative real-time RT-PCR...
October 4, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28967976/highlighting-interleukin-36-signalling-in-plaque-psoriasis-and-pustular-psoriasis
#18
Kazuhisa Furue, Kazuhiko Yamamura, Gaku Tsuji, Chikage Mitoma, Hiroshi Uchi, Takeshi Nakahara, Makiko Kido-Nakahara, Takafumi Kadono, Masutaka Furue
Plaque psoriasis and pustular psoriasis are overlapping, but distinct, disorders. The therapeutic response to biologics supports the pivotal role of the tumour necrosis alpha (TNF-α)/ interleukin (IL)-23/IL-17/IL-22 axis in the pathogenesis of these disorders. Recently, functional activation of the IL-36 receptor (IL-36R) was discovered to be another driving force in the pathogenesis of psoriasis. This was first highlighted by the discovery that a loss-of-function mutation of the IL-36R antagonist (IL-36Ra) causes pustular psoriasis...
October 2, 2017: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/28964890/safety-tolerability-and-pharmacodynamics-of-an-anti-interleukin-1%C3%AE-%C3%AE-dual-variable-domain-immunoglobulin-in-patients-with-osteoarthritis-of-the-knee-a-randomized-phase-1-study
#19
S X Wang, S B Abramson, M Attur, M A Karsdal, R A Preston, C J Lozada, M P Kosloski, F Hong, P Jiang, M J Saltarelli, B A Hendrickson, J K Medema
OBJECTIVE: To investigate the safety, tolerability, pharmacokinetics, and pharmacodynamics of ABT-981, a human dual variable domain immunoglobulin simultaneously targeting interleukin (IL)-1α and IL-1β, in patients with knee osteoarthritis (OA). METHOD: This was a randomized, double-blind, placebo-controlled, single-center study of multiple subcutaneous (SC) injections of ABT-981 in patients with mild-to-moderate OA of the knee (NCT01668511). Three cohorts received ABT-981 (0...
September 28, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28960399/role-of-intracystic-cytokines-and-nitric-oxide-in-ovarian-neoplasms
#20
Agrimaldo Martins Filho, Millena Prata Jammal, Douglas Côbo Micheli, Beatriz Martins Tavares-Murta, Renata Margarida Etchebehere, Eddie Fernando Candido Murta, Rosekeila Simões Nomelini
The development of new biomarkers for the diagnosis and prognosis of ovarian cancer may provide an opportunity for new therapies. In this study, we aimed to compare cytokines (interleukin [IL]-2, IL-5, IL-6, IL-8, IL-10, and tumor necrosis factor [TNF]-α) and nitric oxide (NO) metabolite levels in non-neoplastic tumors, benign primary ovarian tumors, and malignant primary ovarian neoplasms. The secondary aim was to relate cytokine and intracystic NO metabolite levels to clinical, laboratory, and pathologic characteristics for patients with primary ovarian malignancies...
September 28, 2017: Scandinavian Journal of Immunology
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