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Extremely low birth weight

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https://www.readbyqxmd.com/read/29350662/high-protein-intake-in-human-maternal-milk-fortification-for-%C3%A2-1250-gr-infants-intrahospital-growth-and-neurodevelopmental-outcome-at-two-years
#1
Augusto Biasini, Fiorella Monti, Maria Chiara Laguardia, Marcello Stella, Lucia Marvulli, Erica Neri
BACKGROUND AND AIM OF THE STUDY: Extrauterine growth restriction and failure to thrive remain a major problem in Extremely Low Birth Weight infants. Nutritional support in preterm babies has the objective to improve the achieve rate of growth similar to those of the fetus in utero at the equivalent gestational age. The aim of the study was to evaluate feeding tolerance, intrahospital growth, neurological outcome and anthropometric data until 24 months of corrected age (mca) from different protein intake assumed by preterm babies <1250 g during their stay in NICU...
January 16, 2018: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/29345159/weighing-in-on-the-risks-and-benefits-of-probiotic-use-in-hiv-infected-and-immunocompromised-populations
#2
A U Happel, S L Barnabas, R Froissart, J S Passmore
Probiotics are used in the prophylaxis and treatment of several conditions, including irritable bowel syndrome, diarrhoea, necrotising enterocolitis (NEC) and colic in infants. Despite the long history of probiotic use in humans, there is still significant debate about their efficacy and safety, particularly in HIV-infected and immunocompromised individuals. Here, we reviewed the safety and adverse event (AE) reporting from clinical trials that have tested probiotics in at risk populations, including HIV-infected individuals, the terminally ill and elderly, and neonates...
January 18, 2018: Beneficial Microbes
https://www.readbyqxmd.com/read/29313560/surgical-closure-of-patent-ductus-arteriosus-in-extremely-low-birth-weight-infants-less-than-750-grams
#3
Tomasz Stankowski, Sleiman Sebastian Aboulhassan, Dirk Fritzsche, Marcin Misterski, Jakub Marczak, Anna Szymańska, Lukasz Szarpak, Cyprian Augustyn, Romuald Cichoń, Bartłomiej Perek
BACKGROUND: Patent ductus arteriosus (PDA) occurs more frequently in premature infants. Depending on the degree of prematurity, these children often have other serious comorbidities that could significantly impact on surgical outcome. AIM: This study aimed to evaluate clinical results of the surgical ligation of PDA in extremely low body weight preterm infants with birth weight below 750 grams and to identify risk factors of mortality. METHODS: A total of 31 preterm infants with birth weight below 750 grams and significant PDA were operated between 2006 and 2016 through posterolateral thoracotomy (n=16) or with the use of video-assisted thoracoscopic (VATS) method (n = 15)...
January 9, 2018: Kardiologia Polska
https://www.readbyqxmd.com/read/29300196/mesenteric-oxygenation-changes-associated-with-necrotizing-enterocolitis-and-pneumoperitoneum-after-multiple-blood-transfusions-a-case-report
#4
Terri Marin, James E Moore
BACKGROUND: The multifactorial pathology and broad clinical presentation of necrotizing enterocolitis (NEC) development in premature infants make prediction of disease onset extremely challenging. Over the past decade, packed red blood cell (PRBC) transfusions have been temporally linked to the development of NEC in severely anemic preterm infants, although this issue is highly controversial. PURPOSE: In this case study, we describe events of an extremely low birth-weight infant who developed NEC complicated by pneumoperitoneum after receiving multiple PRBC transfusions...
January 3, 2018: Advances in Neonatal Care: Official Journal of the National Association of Neonatal Nurses
https://www.readbyqxmd.com/read/29298438/influence-of-pco2-control-on-clinical-and-neurodevelopmental-outcomes-of-extremely-low-birth-weight-infants
#5
Ulrich H Thome, Jens Dreyhaupt, Orsolya Genzel-Boroviczeny, Bettina Bohnhorst, Manuel Schmid, Hans Fuchs, Oliver Rohde, Stefan Avenarius, Hans-Georg Topf, Andrea Zimmermann, Dirk Faas, Katharina Timme, Barbara Kleinlein, Horst Buxmann, Wilfried Schenk, Hugo Segerer, Norbert Teig, Benjamin Ackermann, Roland Hentschel, Matthias Heckmann, Rolf Schlösser, Jochen Peters, Rainer Rossi, Wolfgang Rascher, Ralf Böttger, Jürgen Seidenberg, Gesine Hansen, Harald Bode, Maria Zernickel, Rainer Muche, Helmut D Hummler
BACKGROUND: Levels or fluctuations in the partial pressure of CO2 (PCO2) may affect outcomes for extremely low birth weight infants. OBJECTIVES: In an exploratory analysis of a randomized trial, we hypothesized that the PCO2 values achieved could be related to significant outcomes. METHODS: On each treatment day, infants were divided into 4 groups: relative hypocapnia, normocapnia, hypercapnia, or fluctuating PCO2. Ultimate assignment to a group for the purpose of this analysis was made according to the group in which an infant spent the most days...
January 4, 2018: Neonatology
https://www.readbyqxmd.com/read/29290747/acetaminophen-for-patent-ductus-arteriosus-in-extremely-low-birth-weight-neonates
#6
Caitlyn M Luecke, Caren J Liviskie, Brandy N Zeller, Zachary A Vesoulis, Christopher McPherson
OBJECTIVE: Although non-steroidal anti-inflammatory drugs (NSAIDs) are the current standard therapy for the treatment of patent ductus arteriosus (PDA), many neonates have contraindications to receiving or may fail NSAID therapy. To avoid surgical ligation, these patients may benefit from an alternative therapy. The objective of this research is to report the efficacy and safety of acetaminophen for the treatment of PDA in a cohort of premature neonates. METHODS: Demographics and clinical course were retrospectively evaluated for all neonates admitted during the study period who received acetaminophen for the treatment of PDA...
November 2017: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/29282354/using-polyethylene-plastic-bag-to-prevent-moderate-hypothermia-during-transport-in-very-low-birth-weight-infants-a-randomized-trial
#7
Xiao-Jing Hu, Li Wang, Ru-Yi Zheng, Tian-Chan Lv, Yu-Xia Zhang, Yun Cao, Guo-Ying Huang
OBJECTIVE: Hypothermia remains a significant problem among very low birth weight (VLBW) infants. The use of occlusive polyethylene plastic bags immediately after birth has been proven to be effective for preterm infants to reduce hypothermia. This study aims to determine whether placing VLBW infants in plastic bags during transport reduces hypothermia. STUDY DESIGN: Study infants were randomly assigned to a standard thermoregulation protocol or to a standard thermoregulation protocol with placement of the torso and lower extremities inside a polyethylene plastic bag during transport...
December 27, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29275926/variation-in-positive-end-expiratory-pressure-levels-for-mechanically-ventilated-extremely-low-birth-weight-infants
#8
Nicolas A Bamat, James P Guevara, Matthew Bryan, Robin S Roberts, Bradley A Yoder, Brigitte Lemyre, Aaron Chiu, David Millar, Haresh Kirpalani
OBJECTIVE: To test the hypothesis that significant positive end-expiratory pressure (PEEP) level variation exists between neonatal centers. STUDY DESIGN: We performed a secondary analysis cohort study of the Nasal Intermittent Positive-Pressure Ventilation trial. Our study population was extremely low birth weight infants requiring mechanical ventilation within 28 days of life. The exposure was neonatal center; 34 international centers participated in the trial...
December 22, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/29274180/association-of-intralipid-intake-in-extremely-low-birth-weight-infants-with-neurodevelopmental-outcomes
#9
William Oh, Lynn Przystac, Leslie McKinley, Richard Tucker, Elisabeth C McGowan, Betty R Vohr
AIM: To determine if high intake of Intralipid, (IL) in extremely low birthweight (ELBW) neonates is associated with higher rates of neuroimpairment and Bayley III scores at 2 years corrected age. METHODS: Quartiles of IL received by 389 ELBW infants were linked to neurodevelopmental outcomes. Logistic regression analyses, adjusted for confounders, were done to determine the association between IL dose and neuroimpairment. Linear regression analyses were done to predict Bayley III scores...
December 23, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/29258174/co-enzyme-q10-and-n-3-polyunsaturated-fatty-acid-supplementation-reverse-intermittent-hypoxia-induced-growth-restriction-and-improved-antioxidant-profiles-in-neonatal-rats
#10
Kay D Beharry, Charles L Cai, Michael M Henry, Sara Chowdhury, Gloria B Valencia, Jacob V Aranda
Neonatal intermittent hypoxia (IH) increases the risk for many morbidities in extremely low birth weight/gestational age (ELBW/ELGA) neonates with compromised antioxidant systems and poor growth. We hypothesized that supplementation with coenzyme Q10 (CoQ10, ubiquinol) or n-3 polyunsaturated fatty acids (PUFAs) during neonatal IH improves antioxidant profiles and somatic growth in neonatal rats. Newborn rats were exposed to two IH paradigms at birth (P0): (1) 50% O₂ with brief hypoxic episodes (12% O₂); or (2) room air (RA) with brief hypoxia, until P14 during which they received daily oral CoQ10 in olive oil, n-3 PUFAs in fish oil, or olive oil only from P0 to P14...
December 16, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/29247118/the-missing-siblings-of-infants-born-preterm
#11
Suvi Alenius, Eero Kajantie, Reijo Sund, Pieta Näsänen-Gilmore, Marja Vääräsmäki, Mika Gissler, Petteri Hovi
BACKGROUND: Parents of very or extremely low birth weight infants have fewer subsequent children after preterm birth. Whether this applies to parents of less preterm infants is unknown. METHODS: In this nationwide cohort study, we identified all 230 308 traceable (>99%) singletons (9983 preterm, 4.3%) live born in Finland between January 1, 1987, and September 30, 1990, and their parents. Quantitative contribution of gestational age of child to the birth of parental subsequent children was assessed by multivariate Cox regression models, stratifying by the number of previous children...
January 2018: Pediatrics
https://www.readbyqxmd.com/read/29246130/enteral-vitamin-a-for-reducing-severity-of-bronchopulmonary-dysplasia-in-extremely-preterm-infants-a-randomised-controlled-trial
#12
Abhijeet Rakshasbhuvankar, Sanjay Patole, Karen Simmer, J Jane Pillow
BACKGROUND: Intramuscular vitamin A supplementation decreases the risk of bronchopulmonary dysplasia (BPD) in very-low-birth-weight preterm infants without significant adverse effects. However, intramuscular vitamin A supplementation is not widely accepted because of the discomfort and risk of trauma associated with repeated injections. Enteral vitamin A supplementation has not been studied adequately in the clinical trials. Enterally administered water-soluble vitamin A is absorbed better than the fat-soluble form...
December 16, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/29229093/bronchopulmonary-dysplasia-a-review-of-pathogenesis-and-pathophysiology
#13
REVIEW
Renjithkumar Kalikkot Thekkeveedu, Milenka Cuevas Guaman, Binoy Shivanna
Bronchopulmonary dysplasia (BPD) is a chronic lung disease of primarily premature infants that results from an imbalance between lung injury and repair in the developing lung. BPD is the most common respiratory morbidity in preterm infants, which affects nearly 10, 000 neonates each year in the United States. Over the last two decades, the incidence of BPD has largely been unchanged; however, the pathophysiology has changed with the substantial improvement in the respiratory management of extremely low birth weight (ELBW) infants...
November 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/29224001/dental-caries-and-developmental-defects-of-enamel-in-the-primary-dentition-of-preterm-infants-case-control-observational-study
#14
Ina Manuela Schüler, Stefanie Haberstroh, Kristin Dawczynski, Thomas Lehmann, Roswitha Heinrich-Weltzien
AIM: Assessment of dental health in the primary dentition of preterm infants (PTI) including investigation of mother- and infant-related risk factors in a case-control study design. MATERIAL AND METHODS: One hundred twenty-eight infants aged 3-4 years were included. Sixty-four PTI (27 males) were randomly selected from the preterm registry of the Jena University Hospital. As a control group served 64 full-term infants (FTI) recruited from the Department of Paediatric Dentistry, matched for age and sex...
December 9, 2017: Caries Research
https://www.readbyqxmd.com/read/29203194/hepatoblastoma-in-an-extremely-low-birth-weight-infant-with-beckwith-wiedemann-syndrome
#15
Yukako Kawasaki, Masami Makimoto, Azusa Samejima, Noriko Yoneda, Ken Higashimoto, Hidenobu Soejima, Taketoshi Yoshida
No abstract text is available yet for this article.
November 21, 2017: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/29201824/assessment-of-preterm-infants-using-the-bayley-iii-scales-in-korea
#16
Sung Ho Ahn, Soo A Kim
Objective: To assess the well-being of preterm newborns using the Bayley-III scales in a Korean-based population, and to evaluate the perinatal risk factors influencing developmental outcome. Methods: Using the Bayley-III scales, we assessed 120 preterm infants who were referred for evaluation of neurodevelopmental performance. We subdivided them into an extremely preterm group (n=18) and a very/moderate to late preterm group (n=102). Bayley-III mean scores and the rate of infants showing a delay were compared for both groups...
October 2017: Annals of Rehabilitation Medicine
https://www.readbyqxmd.com/read/29197251/-the-next-generation-long-term-reproductive-outcome-of-adults-born-at-a-very-low-birth-weight
#17
Lior Drukker, Ziona Haklai, Mor Ben-Yair Schlesinger, Maayan Bas-Lando, Ethel Sherry Gordon, Arnon Samueloff, Michael S Schimmel, Sorina Grisaru-Granovsky
BACKGROUND: Preterm birth at very low birth weight (VLBW, <1500g) has a multitude of consequences that extend to various aspects of adult life. Little is known about the long-term reproductive outcome of VLBW that survive to adulthood. AIMS: To evaluate the reproductive outcome of VLBW infants who survive to adulthood (next-generation). STUDY DESIGN: Retrospective cohort. SUBJECTS: Infants born at a single tertiary center between the years 1982-1997 who survived to 18years of age (first-generation)...
November 29, 2017: Early Human Development
https://www.readbyqxmd.com/read/29196505/trends-in-executive-functioning-in-extremely-preterm-children-across-3-birth-eras
#18
Alice C Burnett, Peter J Anderson, Katherine J Lee, Gehan Roberts, Lex W Doyle, Jeanie L Y Cheong
BACKGROUND AND OBJECTIVES: To determine if executive functioning outcomes at school age are different for extremely preterm (EP; <28 weeks' gestation) or extremely low birth weight (ELBW; <1000 g birth weight) children born in 1991 to 1992, 1997, and 2005 relative to their term-born peers. METHODS: Population-based cohorts of all EP/ELBW survivors born in the state of Victoria, Australia, in 1991 to 1992, 1997, and 2005, and contemporaneous controls (matched for expected date of birth, sex, mother's country of birth [English speaking or not], and health insurance status) were recruited at birth...
December 1, 2017: Pediatrics
https://www.readbyqxmd.com/read/29193158/terlipressin-induced-modifications-of-doppler-ultrasound-signals-of-systemic-arteries-in-preterm-infants-with-vasoactive-resistant-patent-ductus-arteriosus-a-pilot-study
#19
M Radicioni, V Bini, G M Campus, P G Camerini
PURPOSE: To study the effects of terlipressin (TP) infusion on systemic perfusion, estimated with pulsed-wave Doppler ultrasonography of systemic arteries, in a population of extremely low birth-weight (ELBW) preterm infants with vasoactive-resistant ductus arteriosus. METHODS: This prospective, observational cohort included, during five years, 12 ELBW infants with hemodynamically significant patent ductus arteriosus and absent or reversed diastolic flow at Doppler ultrasonography of systemic arteries, despite treatment and high-dose vasoactive support...
November 28, 2017: Journal of Clinical Ultrasound: JCU
https://www.readbyqxmd.com/read/29172239/strictly-controlled-glucose-infusion-rates-are-associated-with-a-reduced-risk-of-hyperglycaemia-in-extremely-low-birth-weight-preterm-infants
#20
Hans Jorgen Stensvold, Astri M Lang, Kenneth Strommen, Tore G Abrahamsen, Bjorn Ogland, Are H Pripp, Arild E Ronnestad
AIM: We evaluated a strict strategy that aimed to avoid fluctuations in glucose infusion rates (GIRs) and assessed the independent effects of maximal daily GIRs on the hyperglycaemia risk among extremely low birth weight (ELBW) infants receiving early enhanced parenteral nutrition. METHODS: This study comprised all ELBW infants admitted to the neonatal intensive care unit of Oslo University Hospital Rikshospitalet, Norway before (2007-2009) and after (2012-2013) implementing a strict GIR strategy...
November 24, 2017: Acta Paediatrica
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