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Extremely low birth weight

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https://www.readbyqxmd.com/read/28632972/non-randomised-interventional-study-showed-that-early-aggressive-nutrition-was-effective-in-reducing-postnatal-growth-restriction-in-preterm-infants
#1
Giulia Genoni, Marco Binotti, Alice Monzani, Elena Bernascone, Ilaria Stasi, Gianni Bona, Federica Ferrero
AIM: This study evaluated whether an early aggressive nutrition (EAN) strategy could limit extrauterine growth restriction (EUGR) in a cohort of preterm infants. METHODS: This prospective non-randomised interventional study was carried out in the neonatal intensive care unit of an Italian hospital from January 2013 to December 2015. The prevalence of EUGR was assessed in 100 infants with a gestational age of ≤34 weeks, 50 after the introduction of an EAN regimen in October 2014 and 50 before...
June 20, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28627946/-the-connection-between-maltreatment-and-preterm-birth-in-the-light-of-psychomotor-development-at-2-years-old
#2
Anna Szabina Szele, Beáta Erika Nagy
INTRODUCTION: Preterm children' development and harmful affecting factors to development are important aspects of public health, because in our country the number of preterm birth is very high. AIM: Description of psychomotor development of preterm children (Brunet-Lézine; Bayley-III) and connection between psychomotor development and maternal abuse history (own questionnaire). METHOD: Extremely (<1000 g) and very low (1000-1500 g) birth weight preterm children at 23-30 months (n = 35) and their mothers' abuse history were measured...
June 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/28627444/associative-role-of-tyms6bpdel-polymorphism-and-resulting-hyperhomocysteinemia-in-the-pathogenesis-of-preterm-delivery-and-associated-complications-a-study-from-northeast-india
#3
Diptika Tiwari, Chandana Ray Das, Purabi Deka Bose, Sujoy Bose
Aberrations including genetic alterations in folate pathway are detrimental in multiple disease pathogenesis, including pregnancy. The present study is based on the screening of the associative role of TYMS 14946bp deletion(del) polymorphism and associated hyperhomocysteinemia in susceptibility to preterm delivery (PTD), which is strongly associated with neonatal mortality and morbidity. METHODS: A total of 209 PTD cases {extremely preterm (n=22), very preterm (n=43) and moderately preterm (n=144)} and 194 term delivery cases were evaluated for TYMS 14946bp deletion and its association with preterm delivery, pregnancy outcome, baby birth weight and homocysteine estimation...
June 13, 2017: Gene
https://www.readbyqxmd.com/read/28622483/human-milk-fortifiers-do-not-meet-the-current-recommendation-for-nutrients-in-very-low-birth-weight-infants
#4
Winston Koo, Hilary Tice
BACKGROUND: Use of multinutrient fortifiers is standard of care for small preterm infants fed exclusively human milk. However, adequacy of human milk fortifiers (HMFs) to meet the recommended intake for macronutrients and micronutrients is now known. MATERIALS AND METHODS: Nutrient content of human milk fortified according to manufacturer's recommendations was compared at isocaloric levels for 1 human milk-based (HMF-A), 2 bovine milk protein-based (HMF-B, HMF-C), and 2 preterm infant formulas (PTF-B, PTF-C)...
June 1, 2017: JPEN. Journal of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28616708/comparison-of-different-definitions-of-acute-kidney-injury-in-extremely-low-birth-weight-infants
#5
Vikas Chowdhary, Ramya Vajpeyajula, Mohit Jain, Syeda Maqsood, Rupesh Raina, Deepak Kumar, Maroun J Mhanna
BACKGROUND: The definition of acute kidney injury (AKI) has evolved over the years, and three definitions have been adapted including pediatric risk injury failure, loss of kidney function (pRIFLE), Acute Kidney Injury Network (AKIN), and Neonatal Modified Kidney Disease Improving Global Outcomes (KDIGO). We sought to report the prevalence and outcome of (AKI) according to the three existing definitions in extremely low birth weight (ELBW) infants. METHODS: In a retrospective cohort study, medical records of all ELBW infants (<1000 g) admitted to our neonatal intensive care unit (NICU) between Jan 2002 and Dec 2011 were reviewed...
June 14, 2017: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/28615304/ibuprofen-exposure-in-early-neonatal-life-does-not-affect-renal-function-in-young-adolescence
#6
Anke Raaijmakers, Zhen-Yu Zhang, Elena Levtchenko, Sinno Hp Simons, Nicholas Cauwenberghs, Lambertus P van den Heuvel, Lotte Jacobs, Jan A Staessen, Karel Allegaert
INTRODUCTION: Ibuprofen exposure results in acute transient renal dysfunction in preterm neonates, but we are unaware of data on long-term renal safety. METHODS: In a previously studied cohort of extreme low birth weight (ELBW, <1000 g) cases, the PREMATurity as predictor of children's Cardiovascular-renal Health study generated data on renal function (renal length, estimated glomerular filtration rate based on cystatin C (eGFRcysC) at the age of 11 years. This data set in 93 ELBW cases may also generate data on long-term drug safety on ibuprofen...
June 14, 2017: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/28614987/role-of-amino-acid-supplementation-in-prevention-of-necrotizing-enterocolitis-in-preterm-neonates-a-review-of-current-evidences
#7
Bhawan Deep Garg, Nandkishor S Kabra
BACKGROUND: Necrotizing enterocolitis (NEC) is one of the most common acute and fatal gastrointestinal emergency in very low birth weight (VLBW) preterm neonates with mortality range from 15-30%. NEC is likely due to multifactorial process such as oxidative injury, ischemic necrosis and over reactive inflammatory response to intestinal microbes. AIMS: To evaluate the role of amino acid supplementation for reduction of neonatal NEC in preterm neonates. METHOD: The literature search was done for various randomized control trial (RCT) by searching the Cochrane Central Register of Controlled Trials (CENTRAL), PubMed, EMBASE, Web of Science, Scopus, Index Copernicus, African Index Medicus (AIM), Thomson Reuters (ESCI), Chemical Abstracts Service (CAS) and other data base...
June 14, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28609432/protective-effects-of-amniotic-fluid-in-the-setting-of-necrotizing-enterocolitis
#8
REVIEW
Soham Dasgupta, Sunil Kumar Jain
Necrotizing Enterocolitis (NEC) is the most common life threatening condition affecting preterm infants. NEC occurs in 1-5% of all neonatal intensive care admissions and 5-10% of very low birth weight infants. The protective role of human breast milk (BM) has been well established. It has also been shown that amniotic fluid (AF) and breast milk have many similarities in terms of presence of growth and other immune-modulatory factors. This finding led to the initial hypothesis that AF may exert similar protective effects against the development of NEC as does BM...
June 13, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28585081/mental-health-assessed-by-the-strengths-and-difficulties-questionnaire-for-children-born-extremely-preterm-without-severe-disabilities-at-11%C3%A2-years-of-age-a-norwegian-national-population-based-study
#9
Silje Katrine Elgen Fevang, Mari Hysing, Kristian Sommerfelt, Irene Elgen
The aims were to investigate mental health problems with the Strength and Difficulties Questionnaire (SDQ) in children born extremely preterm/extremely low birth weight (EP/ELBW) without severe disabilities compared to controls, and to identify peri-, or neonatal factors possibly predicting later mental health problems. A national Norwegian cohort of 11-year-old EP/ELBW children, excluding those with intellectual disabilities, non-ambulatory cerebral palsy, blindness and/or deafness, was assessed. Parents and teachers completed the SDQ...
June 5, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/28583924/congenital-hypofibrinogenaemia-a-presymptomatic-detection-of-an-extremely-rare-bleeding-disorder-in-preterm-twins
#10
Catherine Mary Breen, Muhammad I Riazat, Naomi McCallion, Michael A Boyle
Twenty-eight-week-old preterm monochorionic-diamniotic twins were admitted to the neonatal intensive care unit secondary to low birth weight and mild respiratory distress syndrome. A low fibrinogen level of less than 0.5 g/L was detected following an abnormal full blood count. They required fibrinogen transfusions until 32 weeks corrected gestation to maintain adequate fibrinogen levels. Parental screening revealed that their mother had a previously undiagnosed hypofibrinogenaemia. Of note, her only symptom was menorrhagia...
June 5, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28571223/neonatal-hyperthyroidism-with-fulminant-liver-failure-a-case-report
#11
Mohammed Hasosah, Khalid Alsaleem, Mansour Qurashi, Abdullah Alzaben
Neonatal hyperthyroidism is a rare disease that is seen in infants born to mothers with Graves' disease. Hepatic manifestation of neonatal hyperthyroidism is extremely rare. We describe a neonate with fulminant liver failure secondary to neonatal hyperthyroidism caused by maternal Graves's disease. The baby was admitted with low birth weight and hepatosplenomegaly. At day 2 of life, the baby was irritable and he developed respiratory distress and fulminant hepatic failure which required mechanical ventilation...
April 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28563973/phototherapy-for-neonatal-hyperbilirubinemia
#12
REVIEW
Susumu Itoh, Hitoshi Okada, Toru Kuboi, Takashi Kusaka
About 60 years ago in England, phototherapy for neonatal hyperbilirubinemia was actually used in clinical practice. It was introduced in Japan about 50 years ago. However, the mechanism of how the serum bilirubin concentration was decreased by the phototherapy was still unknown. The mechanism was identified by chemists, biochemists, and pediatricians. Clarification started with the report that unconjugated bilirubin was excreted into bile after the photoirradiation of Gunn rats. After the molecular conformation of bilirubin by X-ray analysis, the mechanism for bile excretion of unconjugated bilirubin was verified based on geometric configurational photoisomers in the Gunn rat...
May 31, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/28554817/outcome-of-primary-repair-in-extremely-and-very-low-birth-weight-infants-with-esophageal-atresia-distal-tracheoesophageal-fistula
#13
Andreas Schmidt, Florian Obermayr, Justus Lieber, Christian Gille, Frank Fideler, Joerg Fuchs
PURPOSE: The optimal surgical management of extremely (ELBW) and very low-birth-weight (VLBW) neonates with esophageal atresia and distal tracheoesophageal fistula (EA/TEF) (Gross type C) is still debated. The aim of this study was to evaluate the surgical outcome of primary repair in these patients and compare it to ≥1500g neonates. METHODS: Medical records of neonates with repaired EA from 2002 to 2016 were reviewed. RESULTS: 4 ELBW, 7 VLBW, and 24 ≥1500g infants had type C EA/TEF and underwent primary repair...
May 17, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28527815/neuroimaging-and-neuropathological-characteristics-of-cerebellar-injury-in-extremely-low-birth-weight-infants
#14
Mayumi Matsufuji, Nozomi Sano, Hisashi Tsuru, Sachio Takashima
OBJECTIVE: To determine the morphological characteristics and pathogenic factors of cerebellar injury in extremely low birth weight infants (ELBWI). SUBJECTS AND METHODS: Neuroimaging examination was performed on 17 eligible surviving ELBWI. Their MR images were assessed and classified its pattern of cerebellar injuries. Brain pathology was examined on 15 patients, who isolated this neuroimaging subjects. The trend of brain pathologies was revealed. RESULTS: Four types of morphological pattern were recognized: (i) the absence of major portions in the cerebellum (6/17 cases); (ii) focal cerebellar tissue loss (2/17); (iii) unilateral cerebellar atrophy/hypoplasia (3/17); (iv) small cerebellum with entrapped fourth ventricle (6/17)...
May 17, 2017: Brain & Development
https://www.readbyqxmd.com/read/28526224/neurocognitive-outcomes-at-10-years-of-age-in-extremely-preterm-newborns-with-late-onset-bacteremia
#15
H Reeve Bright, Kikelomo Babata, Elizabeth N Allred, Carmina Erdei, Karl C K Kuban, Robert M Joseph, T Michael O'Shea, Alan Leviton, Olaf Dammann
OBJECTIVE: To evaluate the difference in 10-year neurocognitive outcomes between extremely low gestational age newborns without bacteremia and those with suspected or confirmed late-onset bacteremia. STUDY DESIGN: Neurocognitive function was evaluated at 10 years of age in 889 children born at <28 weeks of gestation and followed from birth. Definite (culture-positive) late-onset bacteremia during postnatal weeks 2-4 was identified in 223 children, and 129 children had suspected bacteremia...
May 16, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28498341/replication-of-high-fetal-alcohol-spectrum-disorders-prevalence-rates-child-characteristics-and-maternal-risk-factors-in-a-second-sample-of-rural-communities-in-south-africa
#16
Philip A May, Marlene M De Vries, Anna-Susan Marais, Wendy O Kalberg, David Buckley, Colleen M Adnams, Julie M Hasken, Barbara Tabachnick, Luther K Robinson, Melanie A Manning, Heidre Bezuidenhout, Margaret P Adam, Kenneth L Jones, Soraya Seedat, Charles D H Parry, H Eugene Hoyme
Background: Prevalence and characteristics of fetal alcohol syndrome (FAS) and total fetal alcohol spectrum disorders (FASD) were studied in a second sample of three South African rural communities to assess change. Methods: Active case ascertainment focused on children with height, weight and/or head circumference ≤25th centile and randomly-selected children. Final diagnoses were based on dysmorphology, neurobehavioral scores, and maternal risk interviews. Results: Cardinal facial features, head circumference, and total dysmorphology scores differentiated specific FASD diagnostic categories in a somewhat linear fashion but all FASD traits were significantly worse than those of randomly-selected controls...
May 12, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28491922/epidemiology-of-invasive-fungal-infections-at-two-tertiary-care-neonatal-intensive-care-units-over-a-12-year-period-2000-2011
#17
Roshani R Agarwal, Rajkumar L Agarwal, Xinguang Chen, Jorge L Lua, Jocelyn Y Ang
We conducted a retrospective review of 168 patients with invasive fungal infections from January 2000 to December 2011 in 2 neonatal intensive care units. Patients with Candida bloodstream infection (BSI, n = 152) were further analyzed. C albicans was the most common species overall (47%); however, there was an increase in non-albicans sp from 2006 to 2011. Candida BSI clearance rates were lower in extremely low birth weight infants (77% vs 93%, P = .01) and in patients with C albicans infections (77% vs 91%, P = ...
2017: Global Pediatric Health
https://www.readbyqxmd.com/read/28475228/developmental-programming-of-happiness
#18
Louis A Schmidt, Paz Fortier, Ayelet Lahat, Alva Tang, Karen J Mathewson, Saroj Saigal, Michael H Boyle, Ryan J Van Lieshout
Being born at an extremely low birth weight (ELBW; <1,000 grams) is presumed to reflect a suboptimal intrauterine environment and thus presents an opportunity for examining developmental programming hypotheses. Interfacing prenatal programming and differential susceptibility hypotheses, we tested whether individuals with ELBW in different childhood rearing environments showed different attention biases to positive and negative facial emotions in adulthood. Using the oldest known, prospectively followed cohort of ELBW survivors, we found that relative to normal birth weight controls (NBW; >2,500 grams), ELBW survivors displayed the highest and lowest attention bias to happy faces at age 30-35, depending on whether their total family income at age 8 was relatively low (environmental match) or high (environmental mismatch), respectively...
May 5, 2017: Developmental Psychobiology
https://www.readbyqxmd.com/read/28457611/pros-and-cons-of-red-blood-cell-transfusion-in%C3%A2-extremely-low-birth-weight-infants
#19
EDITORIAL
San-Nan Yang
No abstract text is available yet for this article.
June 2017: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/28435991/polycythemia-capillary-rarefaction-and-focal-glomerulosclerosis-in-two-adolescents-born-extremely-low-birth-weight-and-premature
#20
Nariaki Asada, Takanori Tsukahara, Megumi Furuhata, Daisuke Matsuoka, Shunsuke Noda, Kuniaki Naganuma, Akinori Hashiguchi, Midori Awazu
BACKGROUND: Low birthweight infants have a reduced number of nephrons and are at high risk of chronic kidney disease. Preterm birth and/or intrauterine growth restriction (IUGR) may also affect peritubular capillary development, as has been shown in other organs. CASE-DIAGNOSIS/TREATMENT: We report two patients with a history of preterm birth and extremely low birthweight who showed polycythemia and renal capillary rarefaction. Patient 1 and 2, born at 25 weeks of gestation with a birthweight of 728 and 466 g, showed mild proteinuria at age 8 and 6 years, respectively...
April 24, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
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