Guofang Zhou, Fei Lu, Songmin Shang, Dahua Shou, Wenyi Wang, Kun Yu, Ruiqi Xie, Guangqian Lan, Enling Hu
Since hemostats are likely to be flushed off a wound by a massive gushing of blood, achieving rapid and effective hemostasis in complex bleeding wounds with powder hemostats continues to be a significant therapeutic challenge. In order to counter the flushing effect of gushing blood, a gas-jet propelled powder hemostat ((COL/PS)4 @CaCO3 -T-TXA+ ) has been developed. (COL/PS)4 @CaCO3 -T-TXA+ dives into the deep bleeding sites of complex wounds for targeted hemostasis. In preparation, protamine sulfate and collagen are first electrostatically deposited on CaCO3 , which is then loaded with thrombin, and finally doped with protonated tranexamic acid (TXA-NH3 + ) to produce the final therapeutic medicine (COL/PS)4 @CaCO3 -T-TXA+ ...
May 3, 2023: Journal of Materials Chemistry. B, Materials for Biology and Medicine