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https://www.readbyqxmd.com/read/27878778/elevated-serum-levels-of-ghrelin-and-tnf-%C3%AE-in-patients-with-cyanotic-and-acyanotic-congenital-heart-disease
#1
Sai Zhang, Gong-Liang Guo, Li-Li Yang, Li-Qun Sun
BACKGROUND: The levels of ghrelin and tumor necrosis factor alpha (TNF-α) are considered biological markers of congenital heart diseases (CHD). The present meta-analysis was conducted to investigate the clinical significance of serum levels of ghrelin and TNF-α in children with (CHD). METHODS: Chinese and English scientific literature databases were searched to retrieve published studies relevant to ghrelin, TNF-α and CHD. Manual search was additionally employed to identify other relevant studies from cross-references...
November 23, 2016: World Journal of Pediatrics: WJP
https://www.readbyqxmd.com/read/27836946/heart-transplantation-in-adult-congenital-heart-disease
#2
REVIEW
Luke J Burchill
Heart failure (HF) in adult congenital heart disease (ACHD) is vastly different to that observed in acquired heart disease. Unlike acquired HF in which pharmacological strategies are the cornerstone for protecting and improving ventricular function, ACHD-related HF relies heavily upon structural and other interventions to achieve these aims. patients with ACHD constitute a small percentage of the total adult heart transplant population (∼3%), although the number of ACHD heart transplant recipients is growing rapidly with a 40% increase over the last two decades...
December 1, 2016: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/27834768/design-and-implementation-of-a-prospective-adult-congenital-heart-disease-biobank
#3
Alexander R Opotowsky, Brittani Loukas, Christina Ellervik, Lilamarie E Moko, Michael N Singh, Elizabeth I Landzberg, Eric B Rimm, Michael J Landzberg
BACKGROUND: Adults with congenital heart disease (ACHD) comprise a growing, increasingly complex population. The Boston Adult Congenital Heart Disease Biobank is a program for the collection and storage of biospecimens to provide a sustainable resource for scientific biomarker investigation in ACHD. METHODS: We describe a protocol to collect, process, and store biospecimens for ACHD or associated diagnoses developed based on existing literature and consultation with cardiovascular biomarker epidemiologists...
November 2016: World Journal for Pediatric & Congenital Heart Surgery
https://www.readbyqxmd.com/read/27832613/prognostic-value-of-n-terminal-pro-b-type-natriuretic-peptide-troponin-t-and-growth-differentiation-factor-15-in-adult-congenital-heart-disease
#4
Vivan J Baggen, Annemien van den Bosch, Jannet A Eindhoven, Anne-Rose Schut, Judith A A E Cuypers, Maarten Witsenburg, Monique de Waart, Ron H van Schaik, Felix Zijlstra, Eric Boersma, Jolien W Roos-Hesselink
BACKGROUND: -The number of patients with adult congenital heart disease (ACHD) is rapidly increasing. In order to optimize patient management, there is a great need to accurately identify high-risk patients. Still, no biomarker has been firmly established as a clinically useful prognostic tool in this group. We studied the association of N-terminal pro-B-type natriuretic peptide (NT-proBNP), high-sensitive troponin-T (hs-TnT) and growth-differentiation factor 15 (GDF-15) with cardiovascular events in ACHD...
November 3, 2016: Circulation
https://www.readbyqxmd.com/read/27738072/surgery-for-supraventricular-tachycardia-and-congenital-heart-defects-long-term-efficacy-of-the-combined-approach-in-adult-patients
#5
Alessandro Giamberti, Francesca R Pluchinotta, Massimo Chessa, Alessandro Varrica, Raffaele Vitale, Alessandro Frigiola, Carlo Pappone, Marco Ranucci
AIMS: Supraventricular arrhythmias are a major cause of morbidity and mortality in adult patients with congenital heart disease (CHD). Intraoperative ablation offers an alternative for patients who failed ablation procedures or are requiring concomitant surgical intervention. We present our long-term results with the surgical treatment of arrhythmias in adults with CHD (ACHD) undergoing elective cardiac surgery and the clinical predictors for arrhythmia recurrence. METHODS AND RESULTS: Between 2002 and 2013, 80 consecutive patients with CHD, mean age of 39 years, underwent intraoperative ablation with monopolar irrigated radiofrequency during cardiac surgery procedures...
October 12, 2016: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/27642135/pulmonary-arterial-hypertension-in-congenital-heart-disease-current-perspectives-and-future-challenges
#6
George Giannakoulas, Michael A Gatzoulis
Medical and scientific research in the field of pulmonary arterial hypertension (PAH) in adults with congenital heart disease (ACHD) has gradually become globalized, inclusive and collaborative over the past few years. The education of physicians, health administrators and patients on congenital heart disease (CHD), specifically in the field of PAH, is of paramount importance. It is also crucial for ACHD patients with PAH to be followed in tertiary centers and to benefit from a multidisciplinary approach. Shared care models dictate a closer collaboration between tertiary expert centers and local non-specialist services, as well as networking between expert physicians in CHD and PAH and geneticists/epidemiologists, with the inclusion of PAH-CHD patients in national and international registries with a detailed genotypic/phenotypic characterization...
August 20, 2016: Hellenic Journal of Cardiology: HJC, Hellēnikē Kardiologikē Epitheōrēsē
https://www.readbyqxmd.com/read/27634029/short-term-costs-and-hospitalization-rates-in-patients-with-adult-congenital-heart-disease-after-pulmonic-valve-replacement
#7
Deana Mikhalkova, Eric Novak, Ari Cedars
In the adult congenital heart disease (ACHD) population, pulmonary valve replacement (PVR) is a common intervention, its benefit, however, has been incompletely investigated. This study investigates short- and intermediate-term outcomes after PVR in ACHD. Using State Inpatient Databases from the Healthcare Cost and Utilization Project, we investigated both hospitalization rate and financial burden accrued over the 12-month period after PVR compared with the 12 months before. Among 202 patients who underwent PVR, per patient-year hospitalization rates doubled in the year after PVR compared with the year before (0...
August 22, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/27620913/nt-probnp-and-exercise-capacity-in-adult-patients-with-congenital-heart-disease-and-a%C3%A2-prosthetic-valve-a%C3%A2-multicentre-prostava-study
#8
R C Schoonbeek, P G Pieper, Y J van Slooten, H G Freling, G T Sieswerda, A P J van Dijk, M R M Jongbloed, M C Post, B J Bouma, R M F Berger, T Ebels, J P van Melle
OBJECTIVES: N-terminal B‑type natriuretic peptide (NT-proBNP) is an important biomarker for the detection of heart failure. Adults with congenital heart disease (ACHD) and a prosthetic heart valve are at risk for heart failure. This study aimed to determine the value of NT-proBNP in ACHD patients with a prosthetic valve and investigate its relationship with cardiac function and exercise capacity. METHODS: In this multi-centre cross-sectional observational study, data regarding medical history, echocardiography, exercise testing (VO2peak) and laboratory blood evaluation (including NT-proBNP) were collected in ACHD patients with a single prosthetic valve (either homografts, heterografts or mechanical valves)...
November 2016: Netherlands Heart Journal
https://www.readbyqxmd.com/read/27561764/wait-list-outcomes-for-adults-with-congenital-heart-disease-listed-for-heart%C3%A2-transplantation-in-the-u-s
#9
Laith I Alshawabkeh, Nan Hu, Knute D Carter, Alexander R Opotowsky, KellyAnn Light-McGroary, Joseph E Cavanaugh, Heather L Bartlett
BACKGROUND: Heart failure represents a common end-stage syndrome for many adults with congenital heart disease (ACHD). These patients, however, have been excluded from most heart transplantation research. It is not known how current criteria, derived from non-ACHD populations, used to determine priority at the time of transplant listing, impact the outcomes for ACHD patients listed for heart transplantation. OBJECTIVES: The goal of this study was to investigate outcomes of ACHD in comparison to non-ACHD patients while listed for heart transplantation...
August 30, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27485737/burden-of-heart-failure-in-adults-with-congenital-heart-disease
#10
Laith I Alshawabkeh, Alexander R Opotowsky
Patients born with congenital heart disease (CHD) have benefited from remarkable advances in surgical and catheter-based interventions. As a result, the majority of children born with even the most complex forms of CHD live into adulthood. The specialized field of adult CHD (ACHD) was born out of the necessity to care for this new population of survivors of childhood CHD and their distinctive features. In this review, relevant aspects of ACHD that lead to, and are affected by, heart failure will be examined along with the increasing prevalence of HF in the burgeoning population of ACHD...
October 2016: Current Heart Failure Reports
https://www.readbyqxmd.com/read/27476099/health-care-costs-for-adults-with-congenital-heart-disease-in-the-united-states-2002-to-2012
#11
David A Briston, Elisa A Bradley, Aarthi Sabanayagam, Ali N Zaidi
More adults than children with congenital heart disease (CHD) are alive today. Few studies have evaluated adult congenital heart disease (ACHD) health care utilization in the United States. Data from the National Inpatient Sample from 2002 to 2012, using International Classification of Diseases, Ninth Revision, codes for moderate and complex CHD were analyzed. Hospital discharges, total billed and reimbursed amounts, length of stay, and gender/age disparities were evaluated. There was an increase in CHD discharges (moderate CHD: 4,742 vs 6,545; severe CHD: 807 vs 1,115) and total billed and reimbursed dollar amounts across all CHD (billed: $2...
August 15, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/27436116/postcardiotomy-ecmo-support-after-high-risk-operations-in-adult-congenital-heart-disease
#12
Benjamin Acheampong, Jonathan N Johnson, John M Stulak, Joseph A Dearani, Sudhir S Kushwaha, Richard C Daly, Dawit T Haile, Gregory J Schears
BACKGROUND: Cardiac operations in high-risk adult congenital heart disease (ACHD) patients may require mechanical circulatory support (MCS), such as extracorporeal membrane oxygenation (ECMO) or intraaortic balloon pump (IABP), to allow the cardiopulmonary system to recover. METHODS: We reviewed records for all ACHD patients who required MCS following cardiotomy at our institution from 1/2001 to 12/2013. RESULTS: During the study period, 2264 (mean age 39...
December 2016: Congenital Heart Disease
https://www.readbyqxmd.com/read/27435587/use-of-dofetilide-in-adult-patients-with-atrial-arrhythmias-and-congenital-heart-disease-a-paces-collaborative-study
#13
Iqbal El-Assaad, Sadeer G Al-Kindi, JoEllyn Abraham, Shubhayan Sanatani, David J Bradley, Colby Halsey, Ian H Law, Seshadri Balaji, Ira Shetty, Peter F Aziz
BACKGROUND: Arrhythmia management has become the major treatment challenge in adult patients with congenital heart disease (ACHD). OBJECTIVE: We sought to investigate the utility and safety profile of dofetilide for atrial arrhythmias in ACHD. METHODS: A retrospective chart review was performed. We included patients (age ≥18 years) with congenital heart disease who had atrial fibrillation (AF) or intra-atrial reentrant tachycardia treated with dofetilide...
October 2016: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/27423083/a-time-for-greater-investment-into-care-for-pregnancy-and-heart-disease
#14
EDITORIAL
Matthew Cauldwell, Roshni Patel, Philip Steer, Michael Gatzoulis
Adult Congenital Heart Disease (ACHD) complicating pregnancy remains a relatively new and evolving field. An acceptance by paediatric cardiologists of the importance of working alongside their colleagues dealing with adult care as their patients get older is vital to ensure that these patients are provided with seamless continuity of care. One might have expected that as ACHD cardiologists increasingly forge ties with obstetricians who manage high risk pregnancy so that together they provide care for their mutual patients, we would see the mortality and morbidity of pregnancy in women with heart disease decline...
October 15, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27382106/congenital-heart-disease-epidemiology-in-the-united-states-blindly-feeling-for-the-charging-elephant
#15
EDITORIAL
Richard A Krasuski, Thomas M Bashore
No abstract text is available yet for this article.
July 12, 2016: Circulation
https://www.readbyqxmd.com/read/27367306/mental-disorders-in-adults-with-congenital-heart-disease-unmet-needs-and-impact-on-quality-of-life
#16
Mechthild Westhoff-Bleck, Juliane Briest, Daniela Fraccarollo, Denise Hilfiker-Kleiner, Lotta Winter, Ulrike Maske, Markus A Busch, Stefan Bleich, Johann Bauersachs, Kai G Kahl
OBJECTIVE: In adult congenital heart disease (ACHD), mental health status and quality of life become important issues due to improved life expectancy. Current literature provides conflicting data regarding mental health status in ACHD. Furthermore, none of the studies so far compared prevalence rates with a matched control group. METHODS: The prevalence of mental disorders was assessed in 150 ACHD using a structured interview, and compared to 12-months estimates of the general German population...
November 1, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27312002/management-of-supraventricular-arrhythmias-in-adults-with-congenital-heart-disease
#17
REVIEW
Kristina Wasmer, Lars Eckardt
Supraventricular arrhythmias are a frequent complication in adults with congenital heart disease (ACHD). The prevalence increases with time since surgery, complexity of the underlying defect, type of repair and older age at surgery. Arrhythmias are the most frequent reason for hospital admission and along with heart failure the leading cause of death. The arrhythmia-associated increase in morbidity and mortality makes their management a key task in patients with ACHD. Intra-atrial re-entry is the most frequent arrhythmia mechanism...
October 15, 2016: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/27266868/a-cluster-randomized-trial-of-a-transition-intervention-for-adolescents-with-congenital-heart-disease-rationale-and-design-of-the-chapter-2-study
#18
Andrew S Mackie, Gwen R Rempel, Adrienne H Kovacs, Miriam Kaufman, Kathryn N Rankin, Ahlexxi Jelen, Cedric Manlhiot, Samantha J Anthony, Joyce Magill-Evans, David Nicholas, Renee Sananes, Erwin Oechslin, Dimi Dragieva, Sonila Mustafa, Elina Williams, Michelle Schuh, Brian W McCrindle
BACKGROUND: The population of adolescents and young adults with congenital heart disease (CHD) is growing exponentially. These survivors are at risk of late cardiac complications and require lifelong cardiology care. However, there is a paucity of data on how to prepare adolescents to assume responsibility for their health and function within the adult health care system. Evidence-based transition strategies are required. METHODS: The Congenital Heart Adolescents Participating in Transition Evaluation Research (CHAPTER 2) Study is a two-site cluster randomized clinical trial designed to evaluate the efficacy of a nurse-led transition intervention for 16-17 year olds with moderate or complex CHD...
2016: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/27234868/long-term-follow-up-of-implantable-cardioverter-defibrillators-in-adult-congenital-heart-disease-patients-indications-and-outcomes
#19
Sandhya Santharam, Lucy Hudsmith, Sara Thorne, Paul Clift, Howard Marshall, Joseph De Bono
AIMS: Ventricular arrhythmias are a major cause of mortality in adult congenital heart disease (ACHD) patients. The European Society of Cardiology guidelines state that implantable cardioverter-defibrillators (ICD) should be considered in patients with congenital heart disease following spontaneous sustained ventricular tachycardia (VT) or cardiac arrest and in patients at presumed high risk. This study sought to analyse the circumstances in which ACHD patients received ICD and to assess outcomes of ICD implantation, including therapies delivered and the rate of complications...
May 26, 2016: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/27234354/extra-cardiac-manifestations-of-adult-congenital-heart-disease
#20
REVIEW
Stephen A Gaeta, Cary Ward, Richard A Krasuski
Advancement in correction or palliation of congenital cardiac lesions has greatly improved the lifespan of congenital heart disease patients, resulting in a rapidly growing adult congenital heart disease (ACHD) population. As this group has increased in number and age, emerging science has highlighted the systemic nature of ACHD. Providers caring for these patients are tasked with long-term management of multiple neurologic, pulmonary, hepatic, renal, and endocrine manifestations that arise as syndromic associations with congenital heart defects or as sequelae of primary structural or hemodynamic abnormalities...
October 2016: Trends in Cardiovascular Medicine
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