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https://www.readbyqxmd.com/read/30007341/quantification-of-torque-teno-virus-viremia-as-a-prospective-biomarker-for-infectious-disease-in-kidney-allograft-recipients
#1
Robert Strassl, Martin Schiemann, Konstantin Doberer, Irene Görzer, Elisabeth Puchhammer-Stöckl, Farsad Eskandary, Željko Kikic, Guido A Gualdoni, Mathias G Vossen, Susanne Rasoul-Rockenschaub, Harald Herkner, Georg A Böhmig, Gregor Bond
Background: Drug-induced immunosuppression following kidney transplantation is crucial to prevent allograft rejection, but increases risk for infectious disease. Tailoring of drug dosing to prevent both rejection and infection is greatly desirable. The apathogenic and ubiquitous torque teno virus (TTV) reflects immunocompetence of the host and might be a potential candidate for immunologic monitoring. Methods: To assess TTV as an infection biomarker, virus load was prospectively quantified in peripheral blood of 169 consecutive renal allograft recipients at the Medical University Vienna...
July 11, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/30007314/effects-of-erythropoietin-on-fibroblast-growth-factor-23-in-mice-and-humans
#2
Mark R Hanudel, Michele F Eisenga, Maxime Rappaport, Kristine Chua, Bo Qiao, Grace Jung, Victoria Gabayan, Barbara Gales, Georgina Ramos, Maarten A de Jong, Jelmer J van Zanden, Martin H de Borst, Stephan J L Bakker, Elizabeta Nemeth, Isidro B Salusky, Carlo A J M Gaillard, Tomas Ganz
Background: Erythropoietin (EPO) has been reported as a novel determinant of fibroblast growth factor 23 (FGF23) production; however, it is unknown whether FGF23 is stimulated by chronic exposure to EPO or by EPO administration in nonpolycystic chronic kidney disease (CKD) models. Methods: We analyzed the effects of chronic EPO on FGF23 in murine models with chronically high EPO levels and normal kidney function. We studied the effects of exogenous EPO on FGF23 in wild-type mice, with and without CKD, injected with EPO...
July 10, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/30007296/risk-of-progressive-chronic-kidney-disease-in-individuals-with-early-onset-type-2-diabetes-a-prospective-cohort-study
#3
Jian-Jun Liu, Sylvia Liu, Resham L Gurung, Keven Ang, Wern Ee Tang, Chee Fang Sum, Subramaniam Tavintharan, Su Chi Lim
Background: The progression trajectory of renal filtration function has not been well characterized in patients with early-onset type 2 diabetes mellitus (T2DM) although albuminuria is often reported in this population. We aim to study the risk of progressive chronic kidney disease (CKD) in individuals with early-onset T2DM. Methods: In total, 1189 T2DM participants were followed for 3.9 (interquartile range 3.2-4.7) years. Progressive CKD was defined as estimated glomerular filtration rate (eGFR) decline of ≥5 mL/min/1...
July 10, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/30007295/prevalence-and-control-of-hypertension-by-48-h-ambulatory-blood-pressure-monitoring-in-haemodialysis-patients-a-study-by-the-european-cardiovascular-and-renal-medicine-eureca-m-working-group-of-the-era-edta
#4
Pantelis A Sarafidis, Francesca Mallamaci, Charalampos Loutradis, Robert Ekart, Claudia Torino, Antonios Karpetas, Vasileios Raptis, Athanasios Bikos, Aikaterini Papagianni, Olga Balafa, Konstantinos Siamopoulos, Giovanni Pisani, Massimo Morosetti, Antonio Del Giudice, Fillipo Aucella, Luca Di Lullo, Rocco Tripepi, Giovanni Tripepi, Kitty Jager, Friedo Dekker, Gerard London, Carmine Zoccali
Background: Population-specific consensus documents recommend that the diagnosis of hypertension in haemodialysis patients be based on 48-h ambulatory blood pressure (ABP) monitoring. However, until now there is just one study in the USA on the prevalence of hypertension in haemodialysis patients by 44-h recordings. Since there is a knowledge gap on the problem in European countries, we reassessed the problem in the European Cardiovascular and Renal Medicine working group Registry of the European Renal Association-European Dialysis and Transplant Association...
July 10, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/30007245/therapeutic-effects-of-5-2-dibromo-2-4-5-trihydroxydiphenylmethanone-lm49-in-an-experimental-rat-model-of-acute-pyelonephritis-by-immunomodulation-and-anti-inflammation
#5
Yuan Lin Zhang, Xiu E Feng, Rong Rong Chang, Le Hua Zhang, Bao Guo Xiao, Qing Shan Li, Xu Liang Hao
Antibiotics are still the primary therapy for acute pyelonephritis (APN); rarely, natural polyphenols are also used. LM49 is a novel marine bromophenol derivative displaying strong anti-inflammatory effects. We investigated the therapeutic efficacy of LM49 in an experimental rat model of APN. The model was established by injecting 0.5 mL Escherichia coli (ATCC 25922, 108  CFU/mL) into the urinary bladders of Sprague Dawley rats. This model showed increased kidney viscera indices and renal bacterial growth scores, as well as pathological changes in kidneys...
July 11, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/30007232/erythropoietin-alleviates-hyperglycaemia-associated-inflammation-by-regulating-macrophage-polarization-via-the-jak2-stat3-signalling-pathway
#6
Jinjin Cui, Fengyun Zhang, Wei Cao, Yongshun Wang, Jingjin Liu, Xinxin Liu, Tao Chen, Ling Li, Jinwei Tian, Bo Yu
BACKGROUND: Erythropoietin (EPO), which is clinically used for renal anaemia, reportedly exerts beneficial pleiotropic effects in atherosclerosis. This aim of this study was to investigate the effects of EPO on macrophage inflammation and polarization under hyperglycaemic conditions and to identify the effects of EPO-treated macrophage supernatants (SNs) on endothelial cell (EC) function. METHODS: Peritoneal macrophages (pMΦs) were isolated from normal, diabetic or EPO-injected mice...
July 11, 2018: Molecular Immunology
https://www.readbyqxmd.com/read/30007152/temporal-variations-in-kidney-metal-concentrations-and-their-implications-for-retinoid-metabolism-and-oxidative-stress-response-in-wild-yellow-perch-perca-flavescens
#7
Michel A Defo, Louis Bernatchez, Peter G C Campbell, Patrice Couture
The objective of this study was to determine if temporal variations in tissue metal concentrations are related to biomarkers of retinoid metabolism and oxidative stress responses in juvenile yellow perch (Perca flavescens). To this end, kidney metal (Cd, Cu and Zn) concentrations were measured in fish sampled in spring and fall 2012 in four lakes representing a wide range of water and sediment metal contamination in the Rouyn-Noranda (Quebec) region. Lakes Opasatica and Hélène were considered as reference lakes while lakes Dufault and Marlon were metal-contaminated...
June 9, 2018: Aquatic Toxicology
https://www.readbyqxmd.com/read/30007072/early-allograft-inflammation-and-scarring-associate-with-graft-dysfunction-and-poor-outcomes-in-renal-transplant-recipients-with-delayed-graft-function
#8
Aravind Cherukuri, Rajil Mehta, Puneet Sood, Sundaram Hariharan
Early histological progression that associates with Delayed Graft Function (DGF) and its relationship to graft outcomes is less well understood. We systematically evaluated early acute and chronic histological changes associated with DGF through serial biopsies (protocol: 3 and 12mos; for-cause) and related them to graft outcomes. 56/294 (19.04%) of our patients had DGF. DGF was associated with a progressive increase in both Banff 't' and 'i' scores from 2 weeks to 3 and 12 months with a resultant increase in T cell mediated Rejection (TCMR) that was significantly greater than those with primary graft function (PGF)...
July 14, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/30007044/conditional-survival-of-patients-with-small-renal-masses-undergoing-active-surveillance
#9
Firas G Petros, Aradhana M Venkatesan, Diana Kaya, Chaan S Ng, Bryan M Fellman, Jose A Karam, Christopher G Wood, Surena F Matin
OBJECTIVES: To determine conditional survival for patients with small renal masses (SRM) undergoing active surveillance (AS). MATERIALS AND METHODS: Patients were enrolled in a prospective AS protocol at our institution between May 2005 and January 2016. Patients with SRM ≤4cm with serial cross-sectional imaging available in-house for review were included. Overall survival (OS) was estimated using Kaplan-Meier method and modeled via Cox proportional hazards models...
July 14, 2018: BJU International
https://www.readbyqxmd.com/read/30006919/prevalence-of-overlap-of-antineutrophil-cytoplasmic-antibody-associated-vasculitis-with-systemic-autoimmune-diseases-an-unrecognized-example-of-poliautoimmunity
#10
Eduardo Martín-Nares, Diego Zuñiga-Tamayo, Andrea Hinojosa-Azaola
We aimed to estimate the frequency of overlap of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) with systemic autoimmune diseases. Retrospective single-center study to identify patients with AAV diagnosis and concomitant autoimmune systemic diseases, simultaneously, before or after the diagnosis of AAV. Sociodemographic characteristics, such as comorbidities; follow-up time; type of AAV; disease duration; relapses; treatment and response; clinical, serological, and histological characteristics; disease activity and damage; prognosis; dialysis requirements, and death were assessed...
July 14, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/30006918/serum-soluble-cxcl16-in-juvenile-systemic-lupus-erythematosus-a-promising-predictor-of-disease-severity-and-lupus-nephritis
#11
Arwa Mohammad Hassan, Nessma Mohamed Ahmed Farghal, Doaa Salah Hegab, Wesam Salah Mohamed, Hend Hassan Abd-Elnabi
Juvenile systemic lupus erythematosus (jSLE) is a multisystem autoimmune disease of unpredicted course and prognosis. Rates of organ involvement in SLE are higher in children, and overt lupus nephropathy is more often a presenting manifestation of SLE in children than adults. Inflammatory soluble chemokine CXC motif-ligand 16 (sCXCL16) is an important pathogenic mediator in inflammatory diseases as SLE. Herein, we aimed to evaluate serum level of sCXCL16 in jSLE patients in comparison to healthy controls and to correlate it with disease activity and extent of cutaneous and renal affection, to detect its possible role in disease pathogenesis...
July 13, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/30006819/gadobutrol-a-review-in-contrast-enhanced-mri-and-mra
#12
Lesley J Scott
Intravenous gadobutrol [Gadovist™ (EU); Gadavist® (USA)] is a second-generation, extracellular non-ionic macrocyclic gadolinium-based contrast agent (GBCA) that is approved for use in paediatric (including term neonates) and adult patients undergoing diagnostic contrast-enhanced (CE) MRI for visualization of pathological lesions in all body regions or for CE MRA to evaluate perfusion and flow-related abnormalities. Its unique physicochemical profile, including its high thermostability and proton relaxation times, means that gadobutrol is formulated at twice the gadolinium ion concentration of other GBCAs, resulting in a narrower bolus and consequently, improved dynamic image enhancement...
July 13, 2018: Clinical Drug Investigation
https://www.readbyqxmd.com/read/30006787/the-biocompatibility-and-bioactivity-of-hemodialysis-membranes-their-impact-in-end-stage-renal-disease
#13
REVIEW
Michaela Kohlová, Célia Gomes Amorim, Alberto Araújo, Alice Santos-Silva, Petr Solich, Maria Conceição B S M Montenegro
End-stage renal disease is a growing health problem with increasing prevalence and high health care costs. Patients suffering from end-stage renal disease exhibit higher morbidity and mortality rates compared to the general population. These patients, who are treated using hemodialysis, typically suffer from anemia, inflammation, and oxidative stress. Inadequate dialyzer membrane biocompatibility exacerbates these negative side effects. Modifications of the composition of hemodialysis membranes have improved their biocompatibility and improve the patients' quality of life...
July 14, 2018: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
https://www.readbyqxmd.com/read/30006786/the-diagnostic-value-of-human-epididymis-protein-4-as-a-novel-biomarker-in-patients-with-renal-dysfunction
#14
Lunshan Wang, Yuhuai Sun, Xinan Cai, Guifeng Fu
PURPOSE: In this study, we investigated the diagnostic value of human epididymis protein 4 (HE4) in acute and chronic renal dysfunction and analyzed the correlation between HE4 levels and the results of routine renal function tests. We aimed to provide evidence to establish HE4 as a novel biomarker of renal injury and its appropriate application as a marker of ovarian cancer. METHODS: We collected 259 serum samples from hospitalized patients with different causes of renal damage...
July 13, 2018: International Urology and Nephrology
https://www.readbyqxmd.com/read/30006764/guropa-survey-genito-urinary-radiation-oncology-prescription-attitudes
#15
Sergio Fersino, Stefano Arcangeli, Barbara Alicja Jereczek-Fossa, Rolando D'Angelillo, Filippi Bertoni, Giuseppe Roberto D'Agostino, Luca Triggiani, Renzo Corvò, Stefano Maria Magrini, Filippo Alongi
AIMS: To investigate the role of Radiation Oncology in the management of genito-urinary (GU) cancer excluding prostate and penile cancer. METHODS: The questionnaire was focused on the evaluation of the degree of involvement of radiation oncologists in the work-up of bladder, renal cell carcinoma and testicular cancer (TC). RESULTS: Eighty-eight radiation oncologists completed the survey. The majority (85.4%) of participating radiation oncologists were senior consultants (> 5 years of experience)...
July 13, 2018: La Radiologia Medica
https://www.readbyqxmd.com/read/30006646/renal-output-efficiency-and-normalized-residual-activity-examined-by-technetium-99m-dtpa-renography-have-by-far-greater-specificity-to-diagnose-obstructive-disease-as-compared-to-other-conventional-parameters-of-the-renogram-first-such-study-of-output-efficiency
#16
Slobodanka Lj Beatović, Marija Radulović, Milica M Janković, Vera M Artiko, Boris Ajdinović, Dragana P Šobić-Šaranović
OBJECTIVE: The aim of this study was to assess the diagnostic ability of renal output efficiency (OE), normalized residual activity (NORA) and conventional interpretation of the diethylene triamine pentaacetic acid (99m Tc-DTPA) diuretic renogram (CIR) in diagnosing urine flow obstruction. SUBJECTS AND METHODS: Group A consisted of 73 obstructed kidneys and Group B of 80 kidneys with dilated upper urinary tract. Forty eight kidneys were examined as the control Group C...
July 12, 2018: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/30006641/intravascular-imaging-histopathological-analysis-and-catecholamine-quantification-following-catheter-based-renal-denervation-in-a-swine-model-the-impact-of-prebifurcation-energy-delivery
#17
Joana Delgado-Silva, Raquel Fernandes, Inês R Pita, Frederico C Pereira, Milosz Jaguszewski, Juan Luis Gutiérrez-Chico, Teresa Ribeiro-Rodrigues, Henrique Girão, Adam Ioannou, Lino Gonçalves
The purpose of this study was to evaluate the impact of prebifurcation renal denervation in a swine model and assess its safety through optical coherence tomography (OCT). Prebifurcation renal denervation with a multi-electrode catheter was performed in one renal artery of 12 healthy pigs, with the contralateral artery and kidney being used as controls. Angiograms and OCT pullbacks were obtained peri-procedurally and 1 month post procedure. Renal tissue catecholamines were quantified, and the arterial wall and peri-adventitial tissue were analyzed histologically...
July 13, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/30006640/selective-ablation-of-trpv1-by-intrathecal-injection-of-resiniferatoxin-in-rats-increases-renal-sympathoexcitatory-responses-and-salt-sensitivity
#18
Shuang-Quan Yu, Shuangtao Ma, Donna H Wang
This study tested the hypothesis that selective ablation of transient receptor potential vanilloid type 1 (TRPV1)-positive nerve fibers by intrathecal injection of resiniferatoxin (RTX) enhances renal sympathoexcitatory responses and salt sensitivity. Intrathecal injection of RTX (1.8 μg/kg) to the levels of lower thoracic and upper lumbar spinal cord (T8-L3) increased mean arterial pressure (MAP) in rats fed a normal (NS, 1% NaCl) or high-sodium (HS, 8% NaCl) diet for 4 weeks compared to vehicle-treated rats (NS: 121 ± 2 vs...
July 13, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/30006603/hippo-pathway-affects-survival-of-cancer-patients-extensive-analysis-of-tcga-data-and-review-of-literature
#19
Anello Marcello Poma, Liborio Torregrossa, Rossella Bruno, Fulvio Basolo, Gabriella Fontanini
The disruption of the Hippo pathway occurs in many cancer types and is associated with cancer progression. Herein, we investigated the impact of 32 Hippo genes on overall survival (OS) of cancer patients, by both analysing data from The Cancer Genome Atlas (TCGA) and reviewing the related literature. mRNA and protein expression data of all solid tumors except pure sarcomas were downloaded from TCGA database. Thirty-two Hippo genes were considered; for each gene, patients were dichotomized based on median expression value...
July 13, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30006578/metabolically-healthy-and-unhealthy-obesity-phenotypes-and-risk-of-renal-stone-a-cohort-study
#20
Seolhye Kim, Yoosoo Chang, Kyung Eun Yun, Hyun-Suk Jung, Inah Kim, Young Youl Hyun, Kyu-Beck Lee, Kwan Joong Joo, Heung Jae Park, Hocheol Shin, Seungho Ryu
BACKGROUND/OBJECTIVES: Although obesity is considered an independent risk factor of nephrolithiasis, little is known about the effect of obesity on nephrolithiasis according to metabolic health status. We investigated the association between body mass index (BMI) category and the incidence of nephrolithiasis in metabolically healthy and unhealthy individuals. SUBJECTS/METHODS: The cohort consisted of 270,190 Korean adults free of nephrolithiasis at baseline, who were followed-up annually or biennially for a median of 4...
July 13, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
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