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https://www.readbyqxmd.com/read/28212543/metabotropic-glutamate-receptors-as-a-new-therapeutic-target-for-malignant-gliomas
#1
REVIEW
Mery Stefani Leivas Pereira, Fábio Klamt, Chairini Cássia Thomé, Paulo Valdeci Worm, Diogo Losch de Oliveira
Metabotropic glutamate receptors (mGluR) are predominantly involved in maintenance of cellular homeostasis of central nervous system. However, evidences have suggested other roles of mGluR in human tumors. Aberrant mGluR signaling has been shown to participate in transformation and maintenance of various cancer types, including malignant brain tumors. This review intends to summarize recent findings regarding the involvement of mGluR-mediated intracellular signaling pathways in progression, aggressiveness, and recurrence of malignant gliomas, mainly glioblastomas (GBM), highlighting the potential therapeutic applications of mGluR ligands...
February 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/28212476/-cartilage-island-versus-temporalis-fascia-in-high-risk-tympanic-perforation
#2
Carmen Lucía Durán-Padilla, Jaime Martínez-Chávez, Norma Amador-Licona, Texar Alfonso Pereyra-Nobara
BACKGROUND: The tympanoplasty for high-risk tympanic membrane perforation is a challenge. It is necessary to compare the most useful and feasible surgical technics in our environment for these patients. The objective was to compare the cartilage island tympanoplasty for the treatment of high-risk tympanic membrane perforations versus the use of temporalis fascia. METHODS: Randomized controlled clinical trial in 69 patients of ten years or older, diagnosed with high-risk tympanic membrane perforation in a third level hospital...
2017: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/28192433/review-of-21-cases-of-mycetoma-from-1991-to-2014-in-rio-de-janeiro-brazil
#3
Felipe Maurício Soeiro Sampaio, Bodo Wanke, Dayvison Francis Saraiva Freitas, Janice Mery Chicarino de Oliveira Coelho, Maria Clara Gutierrez Galhardo, Marcelo Rosandiski Lyra, Maria Cristina da Silva Lourenço, Rodrigo de Almeida Paes, Antonio Carlos Francesconi do Valle
Mycetoma is caused by the subcutaneous inoculation of filamentous fungi or aerobic filamentous bacteria that form grains in the tissue. The purpose of this study is to describe the epidemiologic, clinic, laboratory, and therapeutic characteristics of patients with mycetoma at the Oswaldo Cruz Foundation in Rio de Janeiro, Brazil, between 1991 and 2014. Twenty-one cases of mycetoma were included in the study. There was a predominance of male patients (1.3:1) and the average patient age was 46 years. The majority of the cases were from the Southeast region of Brazil and the feet were the most affected anatomical region (80...
February 13, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28187873/-erratum-to-traumatic-optic-neuropathy-report-of-8%C3%A2-cases-and-review-of-the-literature-j-fr-ophtalmol-39-7-2016-603-8
#4
A Le Guern, C Marks-Delesalle, L Borry, J Chekroun, C Ciocanea, C Gruchala, L Gogneaux, A Lossouarn, J-G Mery, L Nielloud, V Vasseur, S Defoort-Dhelemmes
No abstract text is available yet for this article.
February 7, 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/28187631/rediscovery-and-redescription-of-the-abyssal-squat-lobster-i-munidopsis%C3%A2-petalorhyncha-i-baba-2005-crustacea-decapoda-munidopsidae-from-the-northwest-pacific
#5
Tomoyuki Komai, Ivan Marin, Keiichi Kakui
A poorly known abyssal squat lobster, Munidopsis petalorhyncha Baba, 2005 [= Munidopsis subsquamosa latimana Birstein & Zarenkov, 1970], is redescribed on the basis of the holotype from the Kuril Trench at depths of 5060-5130 m and two recently collected specimens from off Japan at depths of 5353-5382 m. Examination of those specimens enabled us to reassess diagnostic characters of the species. Munidopsis petalorhyncha appears closest to M. thieli Türkay, 1975, known from abyssal plain of the eastern Atlantic, but the spinulose lateral margins of the rostrum, the presence of a distinct lateral eye spine, the presence of a distomesial spine on article 3 of the antennal peduncle and spinose ventral (flexor) margins of meri of pereopods 2-4 distinguish M...
January 25, 2017: Zootaxa
https://www.readbyqxmd.com/read/28167324/re-organizing-inpatient-care-saves-legs-in-patients-with-diabetic-foot-infections
#6
Miska Laakso, Mikael Honkasalo, Juha Kiiski, Meri Ala-Houhala, Heidi Haapasalo, Heikki-Jussi Laine, Tiina Luukkaala, Jorma Lahtela, Ilkka Kaartinen
AIMS: In this study, we evaluated the effects of the re-organization of inpatient care for patients with a diabetic foot infection, and the implementation of a specialized multi-disciplinary wound department at an academic tertiary hospital. METHODS: This was a retrospective cohort study, comprising 272 patients treated for diabetic foot infections in 2006-2007 (Group 1, n=124) and 2013-2014 (Group 2, n=148). In 2012, inpatient care of all chronic wounds was centralized at a single wound department with a multi-disciplinary team...
January 22, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28154548/editorial-social-interaction-in-animals-linking-experimental-approach-and-social-network-analysis
#7
EDITORIAL
Cédric Sueur, Frédéric Mery
No abstract text is available yet for this article.
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28130721/response-of-spontaneous-plants-from-an-ex-mining-site-of-elba-island-tuscany-italy-to-metal-loid-contamination
#8
Laura Pistelli, Francesca D'Angiolillo, Elisabetta Morelli, Barbara Basso, Irene Rosellini, Mauro Posarelli, Meri Barbafieri
The release of large amounts of toxic metals in the neighboring sites of abandoned mine areas represents an important environmental risk for the ecosystem, because it adversely affects soil, water, and plant growth. The aim of the present study was to investigate the metal(loid) (As, Cr, Cu, Ni, Pb, and Zn) contents of native Mediterranean plants grown on the ex-mining area of Elba island (Italy), with the prospective of its recovery by further phytoremediation technology. Soil samples were collected and characterized for metal(loid) content in total and potentially available (EDTA-extractable) fractions...
January 27, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28130646/the-effect-of-mirtazapine-on-dopaminergic-psychosis-and-dyskinesia-in-the-parkinsonian-marmoset
#9
Adjia Hamadjida, Stephen G Nuara, Nicolas Veyres, Imane Frouni, Cynthia Kwan, Lamia Sid-Otmane, Mery-Jane Harraka, Jim C Gourdon, Philippe Huot
BACKGROUND: Parkinson's disease (PD) psychosis is encountered in as many as 50% of patients with advanced disease. Treatment options for PD psychosis are few. In fact, only clozapine and pimavanserin have shown efficacy in randomised controlled trials. Clinicians are often reluctant to prescribe the former, due to the risk of agranulocytosis, while the latter is not widely available yet. Because it is already clinically available and exhibits high affinity for serotonin 2A receptors, a target with which both clozapine and pimavanserin interact, we hypothesised that the anti-depressant mirtazapine might be effective to alleviate PD psychosis...
January 27, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28127620/socioeconomic-inequalities-and-severity-of-plaque-psoriasis-at-a-first-consultation-in-dermatology-centers
#10
Emmanuel Mahé, Alain Beauchet, Ziad Reguiai, François Maccari, Mireille Ruer-Mulard, Guillaume Chaby, Thierry Le Guyadec, Eric Estève, Catherine Goujon-Henry, Josiane Parier, Hugues Barthelemy, Edouard Bégon, Henri-Georges Steiner, Nathalie Bénéton, Thierry Boyé, Laure Mery-Bossard, Jean-Luc Schmutz, Pierre Bravard, Michèle-Léa Sigal Resopso
Psoriasis has major physical, psychological, and social impacts: its management should not be restricted by individual financial considerations in Western countries as these have well-structured health systems and social/insurance coverage. We investigated if the socioeconomic characteristics of patients were associated with severity of psoriasis and access to healthcare. In a cross-sectional study, we included 903 patients with psoriasis that were consulting for the first time. We showed that low educational level was associated with severity of disease in multivariate analyses...
January 27, 2017: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/28115215/damaging-heterozygous-mutations-in-nfkb1-lead-to-diverse-immunological-phenotypes
#11
Meri Kaustio, Emma Haapaniemi, Helka Göös, Timo Hautala, Giljun Park, Jaana Syrjänen, Elisabet Einarsdottir, Biswajyoti Sahu, Sanna Kilpinen, Samuli Rounioja, Christopher L Fogarty, Virpi Glumoff, Petri Kulmala, Shintaro Katayama, Fitsum Tamene, Luca Trotta, Ekaterina Morgunova, Kaarel Krjutškov, Katariina Nurmi, Kari Eklund, Anssi Lagerstedt, Merja Helminen, Timi Martelius, Satu Mustjoki, Jussi Taipale, Janna Saarela, Juha Kere, Markku Varjosalo, Mikko Seppänen
BACKGROUND: The NF-κB signaling pathway is a key regulator of immune responses. Accordingly, mutations in several NF-κB pathway genes cause immunodeficiency. OBJECTIVE: We sought to identify the cause of disease in three unrelated Finnish kindreds with variable symptoms of immunodeficiency and autoinflammation. METHODS: We applied genetic linkage analysis and next generation sequencing, and functional analyses of NFKB1 and its mutated alleles...
January 20, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28109468/preclinical-models-in-hnscc-a-comprehensive-review
#12
REVIEW
Benoite Méry, Chloé Rancoule, Jean-Baptiste Guy, Sophie Espenel, Anne-Sophie Wozny, Priscilla Battiston-Montagne, Dominique Ardail, Michael Beuve, Gersende Alphonse, Claire Rodriguez-Lafrasse, Nicolas Magné
Head and neck cancer remains a significant public health concern. About 60% of patients die within 5years due to local recurrence. Head and neck squamous cell carcinoma (HNSCC) cell lines are important preclinical models in the search for new therapies against this disease. Furthermore, there is a need to test novel drugs before introduction into clinical practice. A preclinical model that closely resembles the in vivo situation would be highly valuable. In the last few decades, a multicellular spheroid model has gained attention as its behavior was comparable to in vivo tumors...
February 2017: Oral Oncology
https://www.readbyqxmd.com/read/28099552/association-between-the-concentration-of-fine-particles-in-the-atmosphere-and-acute-respiratory-diseases-in-children
#13
Antônio Paula Nascimento, Jane Meri Santos, José Geraldo Mill, Juliana Bottoni de Souza, Neyval Costa Reis, Valdério Anselmo Reisen
OBJECTIVE: To analyze the association between fine particulate matter concentration in the atmosphere and hospital care by acute respiratory diseases in children. METHODS: Ecological study, carried out in the region of Grande Vitória, Espírito Santo, in the winter (June 21 to September 21, 2013) and summer (December 21, 2013 to March 19, 2014). We assessed data of daily count for outpatient care and hospitalization by respiratory diseases (ICD-10) in children from zero to 12 years in three hospitals in the Region of Grande Vitória...
January 12, 2017: Revista de Saúde Pública
https://www.readbyqxmd.com/read/28088601/mid-term-outcomes-in-patients-with-congenitally-corrected-transposition-of-the-great-arteries-a-single-center-experience
#14
Luis E De León, Carlos M Mery, Raymond A Verm, Daniel Trujillo-Díaz, Ankita Patro, Francisco A Guzmán-Pruneda, Iki Adachi, Jeffrey S Heinle, Lauren C Kane, E Dean McKenzie, Charles D Fraser
INTRO: The optimal management of patients with congenitally-corrected transposition of the great arteries (ccTGA) is unclear. The goal of this study was to compare the outcomes in patients with ccTGA undergoing different management strategies. METHODS: Patients with ccTGA believed suitable for biventricular circulation treated in 1995-2016 were included. The cohort was divided into four groups: systemic right ventricle (RV) (patients without surgical intervention or with a classic repair), anatomic repair, Fontan palliation, and patients only receiving a pulmonary artery band (PAB) or a shunt...
January 11, 2017: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/28070290/cancer-brings-forward-oviposition-in-the-fly-drosophila-melanogaster
#15
Audrey Arnal, Camille Jacqueline, Beata Ujvari, Lucas Leger, Céline Moreno, Dominique Faugere, Aurélie Tasiemski, Céline Boidin-Wichlacz, Dorothée Misse, François Renaud, Jacques Montagne, Andreu Casali, Benjamin Roche, Frédéric Mery, Frédéric Thomas
Hosts often accelerate their reproductive effort in response to a parasitic infection, especially when their chances of future reproduction decrease with time from the onset of the infection. Because malignancies usually reduce survival, and hence potentially the fitness, it is expected that hosts with early cancer could have evolved to adjust their life-history traits to maximize their immediate reproductive effort. Despite the potential importance of these plastic responses, little attention has been devoted to explore how cancers influence animal reproduction...
January 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28064517/experiences-of-patients-undergoing-repeated-intravitreal-anti-vascular-endothelial-growth-factor-injections-for-neovascular-age-related-macular-degeneration
#16
Jessica Boyle, Meri Vukicevic, Konstandina Koklanis, Catherine Itsiopoulos, Gwyneth Rees
Current therapy to slow disease progression in patients with neovascular age-related macular degeneration (AMD) entails regular intravitreal anti-vascular endothelial growth factor (VEGF) injections, often indefinitely. Little is known about the burden imposed on patients by this repetitive treatment schedule and how this can be best managed. The aim of this study was to explore the psychosocial impact of repeated intravitreal injections on patients with neovascular AMD. Forty patients (16 males, 24 females) with neovascular AMD undergoing anti-VEGF treatment were recruited using purposive sampling from a private ophthalmology practice and public hospital in Melbourne...
January 9, 2017: Psychology, Health & Medicine
https://www.readbyqxmd.com/read/28051966/operational-perspective-of-lessons-learned-from-the-ebola-crisis
#17
Zygmunt F Dembek, Jerry L Mothershead, Tesema Chekol, David B Myers, Ronald G Meris, Dana Meranus, Aiguo Wu
Given its potential to quickly spread internationally and initially uncontrollable nature, the 2014 to 2015 Ebola outbreak has implications for global biosecurity. The Defense Threat Reduction Agency's Technical Reachback provided near real-time analysis and recommendations as outbreak-relevant events unfolded. Our review of often-conflicting or incomplete information was required to answer policy decision makers about the expanding Ebola epidemic, and enable the formulation of best-possible U.S. Department of Defense and Government response...
January 2017: Military Medicine
https://www.readbyqxmd.com/read/28007069/the-acgme-fellowship-in-congenital-cardiac-surgery-the-graduates-perspective
#18
REVIEW
Carlos M Mery, Lauren C Kane
The creation of structured fellowship programs in congenital heart surgery (CHS) in the United States appears to have improved the training of congenital heart surgeons. However, the transition process between fellowship and clinical practice and the lack of senior mentorship continue to be major problems. We report the results of a survey of all graduates of accredited programs in CHS. A total of 35/51 (69%) graduates responded to the survey. Of 34 that are in practice, 31 (91%) did not feel ready to engage in solo CHS after completion of training...
January 2017: Seminars in Thoracic and Cardiovascular Surgery. Pediatric Cardiac Surgery Annual
https://www.readbyqxmd.com/read/28002965/in-vitro-and-in-vivo-anti-trypanosoma-cruzi-activity-of-new-arylamine-mannich-base-type-derivatives
#19
Elsa Moreno-Viguri, Carmen Jiménez-Montes, Rubén Martín-Escolano, Mery Santivañez-Veliz, Alvaro Martin-Montes, Amaya Azqueta, Marina Jimenez-Lopez, Salvador Zamora Ledesma, Nuria Cirauqui, Adela López de Ceráin, Clotilde Marín, Manuel Sánchez-Moreno, Silvia Pérez-Silanes
Chagas disease is a neglected tropical disease with 6-7 million people infected worldwide, and there is no effective treatment. Therefore, there is an urgent need to continue researching in order to discover novel therapeutic alternatives. We present a series of arylaminoketone derivatives as means of identifying new drugs to treat Chagas disease in the acute phase with greater activity, less toxicity, and a larger spectrum of action than that corresponding to the reference drug benznidazole. Indexes of high selectivity found in vitro formed the basis for later in vivo assays in BALB/c mice...
December 22, 2016: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27979266/anodic-stripping-voltammetry-with-gold-electrodes-as-an-alternative-method-for-the-routine-determination-of-mercury-in-fish-comparison-with-spectroscopic-approaches
#20
COMPARATIVE STUDY
Agnese Giacomino, Andrea Ruo Redda, Stefania Squadrone, Marco Rizzi, Maria Cesarina Abete, Carmela La Gioia, Rosanna Toniolo, Ornella Abollino, Mery Malandrino
The applicability to the determination of mercury in tuna of square wave anodic stripping voltammetry (SW-ASV) conducted at both solid gold electrode (SGE) and a gold nanoparticle-modified glassy carbon electrode (AuNPs-GCE) was demonstrated. Mercury content in two certified materials and in ten samples of canned tuna was measured. The performances of the electrodes were compared with one another as well as with two spectroscopic techniques, namely cold vapour atomic absorption spectroscopy (CV-AAS) and a direct mercury analyser (DMA)...
April 15, 2017: Food Chemistry
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