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https://www.readbyqxmd.com/read/28526380/comparison-between-two-assessment-tools-for-fruit-and-vegetable-intake-relative-to-the-24-h-recall
#1
Mariana Souza Lopes, Luana Caroline Dos Santos, Aline Cristine Souza Lopes, Mery Natali Silva Abreu
OBJECTIVE: The aim of this study was to evaluate the validity of methods assessing fruit and vegetable (FV) intake among Brazilian users of the Primary Attention Health Care Program. METHODS: The present study included 299 participants (age ≥20 y) from a representative sample from a randomized controlled community trial performed as part of a health promotion program in a Brazilian metropolis. All participants completed three methods for the assessment of FV consumption: brief questionnaire of FV (QBrief-FV), food frequency questionnaire of FV, and a 24-h dietary recall...
June 2017: Nutrition
https://www.readbyqxmd.com/read/28509365/the-degree-of-satisfaction-of-in-hospital-medical-patients-with-nursing-care-and-predictors-of-dissatisfaction-findings-from-a-secondary-analysis
#2
Alvisa Palese, Silvia Gonella, Anna Fontanive, Annamaria Guarnier, Paolo Barelli, Paola Zambiasi, Elisabetta Allegrini, Letizia Bazoli, Paola Casson, Meri Marin, Marisa Padovan, Michele Picogna, Patrizia Taddia, Daniele Salmaso, Paolo Chiari, Tiziana Frison, Oliva Marognolli, Federica Canzan, Elisa Ambrosi, Luisa Saiani
BACKGROUND: Patient satisfaction with nursing care (NC) is an important predictor of overall satisfaction with the hospital experience. However, the concept of patient satisfaction has been criticised both at the theoretical and at the methodological levels, and more attention on patient dissatisfaction has been called for with the aim of identifying strategies to improve the quality of care. AIMS: To describe dissatisfaction with NC as perceived by acute medical patients and identify predictors...
May 16, 2017: Scandinavian Journal of Caring Sciences
https://www.readbyqxmd.com/read/28508034/laminar-localization-and-projection-specific-properties-of-presubicular-neurons-targeting-the-lateral-mammillary-nucleus-thalamus-or-medial-entorhinal-cortex
#3
Li-Wen Huang, Jean Simonnet, Mérie Nassar, Louis Richevaux, Roxanne Lofredi, Desdemona Fricker
The presubiculum (PrS) is part of an interconnected network of distributed brain regions where individual neurons signal the animals heading direction. PrS sends axons to medial entorhinal cortex (MEC), it is reciprocally connected with anterior thalamic nuclei (ATNs), and it sends feedback projections to the lateral mammillary nucleus (LMN), involved in generating the head direction signal. The intrinsic properties of projecting neurons will influence the pathway-specific transmission of activity. Here, we used projection-specific labeling of presubicular neurons to identify MEC-, LMN-, and ATN-projecting neurons in mice...
March 2017: ENeuro
https://www.readbyqxmd.com/read/28493885/genotypic-and-phenotypic-diversity-of-lactobacillus-rhamnosus-clinical-isolates-their-comparison-with-strain-gg-and-their-recognition-by-complement-system
#4
Eija Nissilä, François P Douillard, Jarmo Ritari, Lars Paulin, Hanna M Järvinen, Pia Rasinkangas, Karita Haapasalo, Seppo Meri, Hanna Jarva, Willem M de Vos
Lactobacillus rhamnosus strains are ubiquitous in fermented foods, and in the human body where they are commensals naturally present in the normal microbiota composition of gut, vagina and skin. However, in some cases, Lactobacillus spp. have been implicated in bacteremia. The aim of the study was to examine the genomic and immunological properties of 16 clinical blood isolates of L. rhamnosus and to compare them to the well-studied L. rhamnosus probiotic strain GG. Blood cultures from bacteremic patients were collected at the Helsinki University Hospital laboratory in 2005-2011 and L...
2017: PloS One
https://www.readbyqxmd.com/read/28493698/4-methyl-6-7-dihydro-4h-triazolo-4-5-c-pyridine-based-p2x7-receptor-antagonists-optimization-of-pharmacokinetic-properties-leading-to-the-identification-of-a-clinical-candidate
#5
Michael A Letavic, Brad M Savall, Brett D Allison, Leah Aliusio, José-Ignacio Andrés, Meri De Angelis, Hong Ao, Derek A Beauchamp, Pascal Bonaventure, Stewart Bryant, Nicholas I Carruthers, Marc Ceusters, Kevin J Coe, Curt A Dvorak, Ian Fraser, Christine F Gelin, Tatiana Koudriakova, Jimmy Liang, Brian Lord, Timothy W Lovenberg, Monica Otieno, Freddy Schoetens, Devin Maun Swanson, Qi Wang, Alan D Wickenden, Anindya Bhattacharya
The synthesis and pre-clinical characterization of novel 4-(R)-methyl-6,7-dihydro-4H-triazolo[4,5-c]pyridines that are potent and selective brain penetrant P2X7 antagonists is described. Optimization efforts based on previously disclosed unsubstituted 6,7-dihydro-4H-triazolo[4,5-c]pyridines, methyl substituted 5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazines and several other series lead to the identification of a series of 4-(R)-methyl-6,7-dihydro-4H-triazolo[4,5-c]pyridines that are selective P2X7 antagonists with potency at the rodent and human P2X7 ion channels...
May 11, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28493446/family-perception-of-unmet-support-needs-following-a-diagnosis-of-congenital-coronary-anomaly-in-children-results-of-a-survey
#6
Hitesh Agrawal, Oriana K Wright, Kathleen E Carberry, S Kristen Sexson Tejtel, Carlos M Mery, Silvana Molossi
BACKGROUND: Long-term outcome data on patients with anomalous aortic origin of coronary arteries (AAOCA) is sparse and they are often managed in a nonuniform manner. There is subjective perception of anxiety and unmet needs in these patients and families. METHODS: An online survey of 13 questions was sent to 74 families of patients with AAOCA between May and October 2015. Descriptive statistics were performed. RESULTS: A total of 31 (47%) families responded...
May 11, 2017: Congenital Heart Disease
https://www.readbyqxmd.com/read/28482850/mutant-tdp-43-does-not-impair-mitochondrial-bioenergetics-in-vitro-and-in-vivo
#7
Hibiki Kawamata, Pablo Peixoto, Csaba Konrad, Gloria Palomo, Kirsten Bredvik, Meri Gerges, Federica Valsecchi, Leonard Petrucelli, John M Ravits, Anatoly Starkov, Giovanni Manfredi
BACKGROUND: Mitochondrial dysfunction has been linked to the pathogenesis of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). Functional studies of mitochondrial bioenergetics have focused mostly on superoxide dismutase 1 (SOD1) mutants, and showed that mutant human SOD1 impairs mitochondrial oxidative phosphorylation, calcium homeostasis, and dynamics. However, recent reports have indicated that alterations in transactivation response element DNA-binding protein 43 (TDP-43) can also lead to defects of mitochondrial morphology and dynamics...
May 8, 2017: Molecular Neurodegeneration
https://www.readbyqxmd.com/read/28479475/the-impact-of-meg-source-reconstruction-method-on-source-space-connectivity-estimation-a-comparison-between-minimum-norm-solution-and-beamforming
#8
Ana-Sofía Hincapié, Jan Kujala, Jérémie Mattout, Annalisa Pascarella, Sebastien Daligault, Claude Delpuech, Domingo Mery, Diego Cosmelli, Karim Jerbi
Despite numerous important contributions, the investigation of brain connectivity with magnetoencephalography (MEG) still faces multiple challenges. One critical aspect of source-level connectivity, largely overlooked in the literature, is the putative effect of the choice of the inverse method on the subsequent cortico-cortical coupling analysis. We set out to investigate the impact of three inverse methods on source coherence detection using simulated MEG data. To this end, thousands of randomly located pairs of sources were created...
May 4, 2017: NeuroImage
https://www.readbyqxmd.com/read/28472440/a-global-cancer-surveillance-framework-within-noncommunicable-disease-surveillance-making-the-case-for-population-based-cancer-registries
#9
Marion Piñeros, Ariana Znaor, Les Mery, Freddie Bray
The growing burden of cancer among several major noncommunicable diseases (NCDs) requires national implementation of tailored public health surveillance. For many emerging economies where emphasis has traditionally been placed on the surveillance of communicable diseases, it is critical to understand the specificities of NCD surveillance and, within it, of cancer surveillance. We propose a general framework for cancer surveillance that permits monitoring the core components of cancer control. We examine communalities in approaches to the surveillance of other major NCDs as well as communicable diseases, illustrating key differences in the function, coverage, and reporting in each system...
January 1, 2017: Epidemiologic Reviews
https://www.readbyqxmd.com/read/28469473/in-vitro-cell-death-determination-for-drug-discovery-a-landscape-review-of-real-issues
#10
REVIEW
Benoite Méry, Jean-Baptiste Guy, Alexis Vallard, Sophie Espenel, Dominique Ardail, Claire Rodriguez-Lafrasse, Chloé Rancoule, Nicolas Magné
Cell death plays a crucial role for a myriad of physiological processes, and several human diseases such as cancer are characterized by its deregulation. There are many methods available for both quantifying and qualifying the accurate process of cell death which occurs. Choosing the right assay tool is essential to generate meaningful data, provide sufficient information for clinical applications, and understand cell death processes. In vitro cell death assays are important steps in the search for new therapies against cancer as the ultimate goal remains the elaboration of drugs that interfere with specific cell death mechanisms...
2017: Journal of Cell Death
https://www.readbyqxmd.com/read/28452681/the-effect-of-vernal-solar-uv-radiation-on-serum-25-hydroxyvitamin-d-concentration-depends-on-the-baseline-level-observations-from-a-high-latitude-in-finland
#11
Toni Karppinen, Meri Ala-Houhala, Lasse Ylianttila, Hannu Kautiainen, Kaisa Lakkala, Henna-Reetta Hannula, Esa Turunen, Heli Viljakainen, Timo Reunala, Erna Snellman
Humans obtain vitamin D from conversion of 7-dehydrocholesterol in the skin by ultraviolet B (UVB) radiation or from dietary sources. As the radiation level is insufficient in winter, vitamin D deficiency is common at higher latitudes. We assessed whether vernal solar UVB radiation at latitudes 61°N and 67°N in Finland has an impact on serum 25-hydroxyvitamin D [S-25(OH)D] concentrations. Twenty-seven healthy volunteers participated in outdoor activities in snow-covered terrain for 4-10 days in March or April, with their face and hands sun-exposed...
2017: International Journal of Circumpolar Health
https://www.readbyqxmd.com/read/28436646/filaments-with-affinity-binding-and-wet-strength-can-be-achieved-by-spinning-bifunctional-cellulose-nanofibrils
#12
Maija Vuoriluoto, Hannes Orelma, Meri Lundahl, Maryam Borghei, Orlando J Rojas
We demonstrate benzophenone (BP) conjugation via amine-reactive esters onto oxidized cellulosic fibers that were used as precursors, after microfluidization, of photoactive cellulose nanofibrils (CNF). From these fibrils, cellulose I filaments were synthesized by hydrogel spinning in an antisolvent followed by fast biradical UV cross-linking. As a result, the wet BP-CNF filaments retained extensively the original dry strength (a remarkable ∼80% retention). Thus, the principal limitation of these emerging materials was overcome (the wet tensile strength is typically <0...
May 3, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28431553/long-working-hours-in-the-healthcare-system-of-the-belo-horizonte-municipality-brazil-a-population-based-cross-sectional-survey
#13
Juliana M Andrade, Ada A Assunção, Mery N S Abreu
BACKGROUND: Health personnel are key players in developing and improving healthcare systems, caring for individuals and their communities, and helping improve quality of life. However, these professionals are often exposed to long working hours because of the pressing need for their services at potentially any time of day. The long working hours they endure are a major risk factor for both acute and chronic health problems. The present study aimed to analyze occurrences of long working hours and their association with individual characteristics and employment factors among workers in the municipal healthcare system in Belo Horizonte, Brazil...
April 21, 2017: Human Resources for Health
https://www.readbyqxmd.com/read/28427233/assessment-of-the-interlaboratory-variability-and-robustness-of-jak2v617f-mutation-assays-a-study-involving-a-consortium-of-19-italian-laboratories
#14
Margherita Perricone, Francesca Palandri, Emanuela Ottaviani, Mario Angelini, Laura Bagli, Enrica Bellesia, Meris Donati, Donato Gemmati, Patrizia Zucchini, Stefania Mancini, Valentina Marchica, Serena Trubini, Giovanna De Matteis, Silvia Di Zacomo, Mosè Favarato, Annamaria Fioroni, Caterina Bolzonella, Giorgia Maccari, Filippo Navaglia, Daniela Gatti, Luisa Toffolatti, Linda Orlandi, Vèronique Laloux, Marco Manfrini, Piero Galieni, Barbara Giannini, Alessia Tieghi, Sara Barulli, Maria Luisa Serino, Monica Maccaferri, Anna Rita Scortechini, Nicola Giuliani, Daniele Vallisa, Massimiliano Bonifacio, Patrizia Accorsi, Cristina Salbe, Vinicio Fazio, Milena Gusella, Eleonora Toffoletti, Marzia Salvucci, Mirija Svaldi, Filippo Gherlinzoni, Francesca Cassavia, Francesco Orsini, Giovanni Martinelli
To date, a plenty of techniques for the detection of JAK2V617F is used over different laboratories, with substantial differences in specificity and sensitivity. Therefore, to provide reliable and comparable results, the standardization of molecular techniques is mandatory.A network of 19 centers was established to 1) evaluate the inter- and intra-laboratory variability in JAK2V617F quantification, 2) identify the most robust assay for the standardization of the molecular test and 3) allow consistent interpretation of individual patient analysis results...
May 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28420540/what-do-we-mean-when-we-talk-about-the-triple-aim-a-systematic-review-of-evolving-definitions-and-adaptations-of-the-framework-at-the-health-system-level
#15
REVIEW
Gustavo Mery, Shilpi Majumder, Adalsteinn Brown, Mark J Dobrow
Notwithstanding important contributions of the Triple Aim, uncritical enthusiasm regarding the implications of the framework may be leading to inconsistent use, particularly when applied at the health system level, which goes beyond the original positioning of the framework as a strategic organizing principle to guide improvement initiatives at the organizational or local community level. We systematically identified uses of the Triple Aim that extended beyond its original intention to focus on uses at the whole health system level, to assess convergence and divergence with the original definition...
April 1, 2017: Health Policy
https://www.readbyqxmd.com/read/28412492/element-variability-in-lacustrine-systems-of-terra-nova-bay-antarctica-and-concentration-evolution-in-surface-waters
#16
Isabella Zelano, Mery Malandrino, Agnese Giacomino, Sandro Buoso, Eleonora Conca, Yann Sivry, Marc Benedetti, Ornella Abollino
Major, minor and trace elements were determined in freshwater of lacustrine systems in Terra Nova Bay, along Victoria Land coast, Antarctica, as well as in algae and mosses. The samples were collected during some of the sampling campaigns between 2007 and 2011 (and the one of 2002) within the framework of the Italian National Program of Research in Antarctica (PNRA). Data were processed with chemometric techniques. Results showed that elements typically considered as potential anthropogenic pollutants (e.g...
April 4, 2017: Chemosphere
https://www.readbyqxmd.com/read/28398524/networking-for-ovarian-rare-tumors-a-significant-breakthrough-improving-disease-management
#17
N Chiannilkulchai, P Pautier, C Genestie, A S Bats, M C Vacher-Lavenu, M Devouassoux-Shisheboran, I Treilleux, A Floquet, S Croce, G Ferron, E Mery, C Pomel, F Penault-Llorca, C Lefeuvre-Plesse, S Henno, E Leblanc, A S Lemaire, G Averous, J E Kurtz, I Ray-Coquard
Background: Rare ovarian tumors represent >20% of all ovarian cancers. Given the rarity of these tumors, natural history, prognostic factors are not clearly identified. The extreme variability of patients (age, histological subtypes, stage) induces multiple and complex therapeutic strategies. Methods: Since 2011, a national network with a dedicated system for referral, up to 22 regional and three national reference centers (RC) has been supported by the French National Cancer Institute (INCa)...
April 7, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28398346/chemical-microenvironments-and-single-cell-carbon-and-nitrogen-uptake-in-field-collected-colonies-of-trichodesmium-under-different-pco2
#18
Meri J Eichner, Isabell Klawonn, Samuel T Wilson, Sten Littmann, Martin J Whitehouse, Matthew J Church, Marcel Mm Kuypers, David M Karl, Helle Ploug
Gradients of oxygen (O2) and pH, as well as small-scale fluxes of carbon (C), nitrogen (N) and O2 were investigated under different partial pressures of carbon dioxide (pCO2) in field-collected colonies of the marine dinitrogen (N2)-fixing cyanobacterium Trichodesmium. Microsensor measurements indicated that cells within colonies experienced large fluctuations in O2, pH and CO2 concentrations over a day-night cycle. O2 concentrations varied with light intensity and time of day, yet colonies exposed to light were supersaturated with O2 (up to ~200%) throughout the light period and anoxia was not detected...
April 11, 2017: ISME Journal
https://www.readbyqxmd.com/read/28390744/atrial-fibrillation-in-cancer-patients-hindsight-insight-and-foresight
#19
Benoîte Mery, Jean-Baptiste Guichard, Jean-Baptiste Guy, Alexis Vallard, Jean-Claude Barthelemy, Antoine Da Costa, Nicolas Magné, Laurent Bertoletti
An increase of atrial fibrillation (AF) incidence in cancer patients has recently been pointed out, with complex interrelationships between these two entities on top of surgery factors. Most of present knowledge comes from retrospective studies or data from registries but the underlying mechanisms of the association between atrial fibrillation and cancer are still unclear. An increased risk of AF in cancer patients could represent a major public health problem although scarce information is available for the challenging management of such patients with distinctive features, especially in terms of antithrombotic therapy...
April 5, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28365206/prevalence-and-incidence-density-of-unavoidable-pressure-ulcers-in-elderly-patients-admitted-to-medical-units
#20
Alvisa Palese, Barbara Trevisani, Annamaria Guarnier, Paolo Barelli, Paola Zambiasi, Elisabetta Allegrini, Letizia Bazoli, Paola Casson, Meri Marin, Marisa Padovan, Michele Picogna, Patrizia Taddia, Daniele Salmaso, Paolo Chiari, Oliva Marognolli, Canzan Federica, Luisa Saiani, Elisa Ambrosi
To describe the prevalence and incidence density of hospital-acquired unavoidable pressure sores among patients aged ≥65 years admitted to acute medical units. A secondary analysis of longitudinal study data collected in 2012 and 2013 from 12 acute medical units located in 12 Italian hospitals was performed. Unavoidable pressure ulcers were defined as those that occurred in haemodynamically unstable patients, suffering from cachexia and/or terminally ill and were acquired after hospital admission. Data at patient and at pressure ulcer levels were collected on a daily basis at the bedside by trained researchers...
March 23, 2017: Journal of Tissue Viability
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