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https://www.readbyqxmd.com/read/28088601/mid-term-outcomes-in-patients-with-congenitally-corrected-transposition-of-the-great-arteries-a-single-center-experience
#1
Luis E De León, Carlos M Mery, Raymond A Verm, Daniel Trujillo-Díaz, Ankita Patro, Francisco A Guzmán-Pruneda, Iki Adachi, Jeffrey S Heinle, Lauren C Kane, E Dean McKenzie, Charles D Fraser
INTRO: The optimal management of patients with congenitally-corrected transposition of the great arteries (ccTGA) is unclear. The goal of this study was to compare the outcomes in patients with ccTGA undergoing different management strategies. METHODS: Patients with ccTGA believed suitable for biventricular circulation treated in 1995-2016 were included. The cohort was divided into four groups: systemic right ventricle (RV) (patients without surgical intervention or with a classic repair), anatomic repair, Fontan palliation, and patients only receiving a pulmonary artery band (PAB) or a shunt...
January 11, 2017: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/28070290/cancer-brings-forward-oviposition-in-the-fly-drosophila-melanogaster
#2
Audrey Arnal, Camille Jacqueline, Beata Ujvari, Lucas Leger, Céline Moreno, Dominique Faugere, Aurélie Tasiemski, Céline Boidin-Wichlacz, Dorothée Misse, François Renaud, Jacques Montagne, Andreu Casali, Benjamin Roche, Frédéric Mery, Frédéric Thomas
Hosts often accelerate their reproductive effort in response to a parasitic infection, especially when their chances of future reproduction decrease with time from the onset of the infection. Because malignancies usually reduce survival, and hence potentially the fitness, it is expected that hosts with early cancer could have evolved to adjust their life-history traits to maximize their immediate reproductive effort. Despite the potential importance of these plastic responses, little attention has been devoted to explore how cancers influence animal reproduction...
January 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28064517/experiences-of-patients-undergoing-repeated-intravitreal-anti-vascular-endothelial-growth-factor-injections-for-neovascular-age-related-macular-degeneration
#3
Jessica Boyle, Meri Vukicevic, Konstandina Koklanis, Catherine Itsiopoulos, Gwyneth Rees
Current therapy to slow disease progression in patients with neovascular age-related macular degeneration (AMD) entails regular intravitreal anti-vascular endothelial growth factor (VEGF) injections, often indefinitely. Little is known about the burden imposed on patients by this repetitive treatment schedule and how this can be best managed. The aim of this study was to explore the psychosocial impact of repeated intravitreal injections on patients with neovascular AMD. Forty patients (16 males, 24 females) with neovascular AMD undergoing anti-VEGF treatment were recruited using purposive sampling from a private ophthalmology practice and public hospital in Melbourne...
January 9, 2017: Psychology, Health & Medicine
https://www.readbyqxmd.com/read/28051966/operational-perspective-of-lessons-learned-from-the-ebola-crisis
#4
Zygmunt F Dembek, Jerry L Mothershead, Tesema Chekol, David B Myers, Ronald G Meris, Dana Meranus, Aiguo Wu
Given its potential to quickly spread internationally and initially uncontrollable nature, the 2014 to 2015 Ebola outbreak has implications for global biosecurity. The Defense Threat Reduction Agency's Technical Reachback provided near real-time analysis and recommendations as outbreak-relevant events unfolded. Our review of often-conflicting or incomplete information was required to answer policy decision makers about the expanding Ebola epidemic, and enable the formulation of best-possible U.S. Department of Defense and Government response...
January 2017: Military Medicine
https://www.readbyqxmd.com/read/28007069/the-acgme-fellowship-in-congenital-cardiac-surgery-the-graduates-perspective
#5
REVIEW
Carlos M Mery, Lauren C Kane
The creation of structured fellowship programs in congenital heart surgery (CHS) in the United States appears to have improved the training of congenital heart surgeons. However, the transition process between fellowship and clinical practice and the lack of senior mentorship continue to be major problems. We report the results of a survey of all graduates of accredited programs in CHS. A total of 35/51 (69%) graduates responded to the survey. Of 34 that are in practice, 31 (91%) did not feel ready to engage in solo CHS after completion of training...
January 2017: Seminars in Thoracic and Cardiovascular Surgery. Pediatric Cardiac Surgery Annual
https://www.readbyqxmd.com/read/28002965/in-vitro-and-in-vivo-anti-trypanosoma-cruzi-activity-of-new-arylamine-mannich-base-type-derivatives
#6
Elsa Moreno-Viguri, Carmen Jiménez-Montes, Rubén Martín-Escolano, Mery Santivañez-Veliz, Alvaro Martin-Montes, Amaya Azqueta, Marina Jimenez-Lopez, Salvador Zamora Ledesma, Nuria Cirauqui, Adela López de Ceráin, Clotilde Marín, Manuel Sánchez-Moreno, Silvia Pérez-Silanes
Chagas disease is a neglected tropical disease with 6-7 million people infected worldwide, and there is no effective treatment. Therefore, there is an urgent need to continue researching in order to discover novel therapeutic alternatives. We present a series of arylaminoketone derivatives as means of identifying new drugs to treat Chagas disease in the acute phase with greater activity, less toxicity, and a larger spectrum of action than that corresponding to the reference drug benznidazole. Indexes of high selectivity found in vitro formed the basis for later in vivo assays in BALB/c mice...
December 22, 2016: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27979266/anodic-stripping-voltammetry-with-gold-electrodes-as-an-alternative-method-for-the-routine-determination-of-mercury-in-fish-comparison-with-spectroscopic-approaches
#7
Agnese Giacomino, Andrea Ruo Redda, Stefania Squadrone, Marco Rizzi, Maria Cesarina Abete, Carmela La Gioia, Rosanna Toniolo, Ornella Abollino, Mery Malandrino
The applicability to the determination of mercury in tuna of square wave anodic stripping voltammetry (SW-ASV) conducted at both solid gold electrode (SGE) and a gold nanoparticle-modified glassy carbon electrode (AuNPs-GCE) was demonstrated. Mercury content in two certified materials and in ten samples of canned tuna was measured. The performances of the electrodes were compared with one another as well as with two spectroscopic techniques, namely cold vapour atomic absorption spectroscopy (CV-AAS) and a direct mercury analyser (DMA)...
April 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27977639/leading-causes-of-cancer-mortality-caribbean-region-2003-2013
#8
Hilda Razzaghi, Sarah Quesnel-Crooks, Recinda Sherman, Rachael Joseph, Betsy Kohler, Glennis Andall-Brereton, Marsha A Ivey, Brenda K Edwards, Les Mery, Vilma Gawryszewski, Mona Saraiya
Cancer is one of the leading causes of deaths worldwide (1); in 2012, an estimated 65% of all cancer deaths occurred in the less developed regions of the world (2). In the Caribbean region, cancer is the second leading cause of mortality, with an estimated 87,430 cancer-related deaths reported in 2012 (3). The Pan American Health Organization defines the Caribbean region as a group of 27 countries that vary in size, geography, resources, and surveillance systems.* CDC calculated site- and sex-specific proportions of cancer deaths and age-standardized mortality rates (ASMR) for 21 English- and Dutch-speaking Caribbean countries, the United States, and two U...
December 16, 2016: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/27955816/-reappraisal-role-of-locoregional-radiation-therapy-in-metastatic-cancers
#9
REVIEW
Chloé Rancoule, Cécile Pacaut-Vassal, Alexis Vallard, Benoite Mery, Jane-Chloé Trone, Anis El Meddeb Hamrouni, Nicolas Magné
Recent innovations in oncology area helped to improve the prognosis of certain cancers including metastatic ones with a decrease in mortality. Recommendations describe the treatment of metastatic cancer as systemic therapy or complementary care and the role of locoregional treatment in the treatment plan only occurs in a palliative context. Currently, in the clinical practice, out of "the evidence based medicine", an early locoregional therapy (surgery or radiation therapy) can be proposed in several cases of metastatic cancers...
December 9, 2016: Bulletin du Cancer
https://www.readbyqxmd.com/read/27939864/a-quick-reference-on-hypokalemia
#10
REVIEW
Márcia Mery Kogika, Helio Autran de Morais
Hypokalemia is more common than hyperkalemia and usually is caused by excessive losses of potassium from the kidneys or gastrointestinal tract. Serum potassium should be investigated in patients developing chronic or frequent vomiting or diarrhea, marked polyuria, muscle weakness, or unexpected cardiac arrhythmias, as well as in those undergoing therapy with insulin, diuretics, or total parenteral nutrition. Clinical signs develop when serum potassium deficit is moderate or severe.
December 8, 2016: Veterinary Clinics of North America. Small Animal Practice
https://www.readbyqxmd.com/read/27939860/a-quick-reference-on-hyperkalemia
#11
REVIEW
Márcia Mery Kogika, Helio Autran de Morais
The clinical signs of hyperkalemia usually are less evident than hypokalemia. Arrhythmia and bradycardia could be the first changes noticed. Most cases of persistent hyperkalemia are associated with renal retention of potassium. Common causes for hyperkalemia include hypoadrenocorticism, ruptured bladder, and urethral or bilateral ureteral obstruction. Drug such as angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, potassium-sparing diuretics, and nonsteroidal antiinflammatory drugs can also lead to hyperkalemia...
December 8, 2016: Veterinary Clinics of North America. Small Animal Practice
https://www.readbyqxmd.com/read/27916571/impact-and-seasonality-of-human-rhinovirus-infection-in-hospitalized-patients-for-two-consecutive-years
#12
Jaqueline Leotte, Hygor Trombetta, Heloisa Z Faggion, Bernardo M Almeida, Meri B Nogueira, Luine R Vidal, Sonia M Raboni
OBJECTIVES: To report epidemiological features, clinical characteristics, and outcomes of human rhinovirus (HRV) infections in comparison with other community acquired respiratory virus (CRV) infections in patients hospitalized for two consecutive years. METHODS: This was a cross-sectional study. Clinical, epidemiological, and laboratory data of patients hospitalized with acute respiratory syndrome in a tertiary care hospital from 2012 to 2013 were reviewed. RESULTS: HRV was the most common CRV observed (36%, 162/444) and was present in the majority of viral co-detections (69%, 88/128), mainly in association with human enterovirus (45%)...
December 2, 2016: Jornal de Pediatria
https://www.readbyqxmd.com/read/27910696/a-new-setup-for-localized-implantation-and-live-characterization-of-kev-energy-multiply-charged-ions-at-the-nanoscale
#13
S Guillous, C Bourin, B Ban D'Etat, A Benyagoub, A Cassimi, C Feierstein, E Gardés, E Giglio, S Girard, C Grygiel, A Houel, H Lebius, A Méry, I Monnet, J-M Ramillon, J Rangama, F Ropars, E Verzeroli, M Viteau, A Delobbe
An innovative experimental setup, PELIICAEN, allowing the modification of materials and the study of the effects induced by multiply charged ion beams at the nanoscale is presented. This ultra-high vacuum (below 5 × 10(-10) mbar) apparatus is equipped with a focused ion beam column using multiply charged ions and a scanning electron microscope developed by Orsay Physics, as well as a scanning probe microscope. The dual beam approach coupled to the scanning probe microscope achieves nanometer scale in situ topological analysis of the surface modifications induced by the ion beams...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27904883/interactions-of-respiratory-viruses-and-the-nasal-microbiota-during-the-first-year-of-life-in-healthy-infants
#14
Insa Korten, Moana Mika, Shkipe Klenja, Elisabeth Kieninger, Ines Mack, Maria Teresa Barbani, Meri Gorgievski, Urs Frey, Markus Hilty, Philipp Latzin
Traditional culture techniques have shown that increased bacterial colonization is associated with viral colonization; however, the influence of viral colonization on the whole microbiota composition is less clear. We thus aimed to understand the interaction of viral infections and the nasal microbiota in early life to appraise their roles in disease development. Thirty-two healthy, unselected infants were included in this prospective longitudinal cohort study within the first year of life. Biweekly nasal swabs (n = 559) were taken, and the microbiota was analyzed by 16S rRNA pyrosequencing, and 10 different viruses and 2 atypical bacteria were characterized by real-time PCR (combination of seven duplex samples)...
November 2016: MSphere
https://www.readbyqxmd.com/read/27895398/dysregulation-of-innate-immunity-in-ulcerative-colitis-patients-who-fail-anti-tumor-necrosis-factor-therapy
#15
Angela C Baird, Dominic Mallon, Graham Radford-Smith, Julien Boyer, Thierry Piche, Susan L Prescott, Ian C Lawrance, Meri K Tulic
AIM: To study the innate immune function in ulcerative colitis (UC) patients who fail to respond to anti-tumor necrosis factor (TNF) therapy. METHODS: Effects of anti-TNF therapy, inflammation and medications on innate immune function were assessed by measuring peripheral blood mononuclear cell (PBMC) cytokine expression from 18 inflammatory bowel disease patients pre- and 3 mo post-anti-TNF therapy. Toll-like receptor (TLR) expression and cytokine production post TLR stimulation was assessed in UC "responders" (n = 12) and "non-responders" (n = 12) and compared to healthy controls (n = 12)...
November 7, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27880982/safety-and-efficacy-of-ruxolitinib-in-splanchnic-vein-thrombosis-associated-with-myeloproliferative-neoplasms
#16
Lisa Pieri, Chiara Paoli, Umberto Arena, Fabio Marra, Fabio Mori, Mery Zucchini, Stefano Colagrande, Alessandro Castellani, Arianna Masciulli, Vittorio Rosti, Valerio De Stefano, Silvia Betti, Guido Finazzi, Maria Luisa Ferrari, Elisa Rumi, Marco Ruggeri, Ilaria Nichele, Paola Guglielmelli, Rajmonda Fjerza, Carmela Mannarelli, Tiziana Fanelli, Lucia Merli, Giuditta Corbizi Fattori, Margherita Massa, Giuseppe Cimino, Alessandro Rambaldi, Giovanni Barosi, Mario Cazzola, Tiziano Barbui, Alessandro M Vannucchi
Splanchnic vein thrombosis (SVT) is one of the vascular complications of myeloproliferative neoplasms (MPN). We designed a phase 2 clinical trial to evaluate safety and efficacy of ruxolitinib in reducing splenomegaly and improving disease-related symptoms in patients with MPN-associated SVT. Patients, diagnosed with myelofibrosis in 12 cases, polycythemia vera in 5 and essential thrombocythemia in 4, received ruxolitinib for 24 weeks in the core study period. Spleen volume was assessed by magnetic resonance imaging (MRI) and splanchnic vein circulation by echo-Doppler analysis...
November 23, 2016: American Journal of Hematology
https://www.readbyqxmd.com/read/27873065/decline-in-territory-size-and-fecundity-as-a-response-to-carrying-capacity-in-an-endangered-songbird
#17
Stefanie A Hartmann, Steffen Oppel, Gernot Segelbacher, Mery E Juiña, H Martin Schaefer
Density-dependent processes are fundamental mechanisms for the regulation of populations. Ecological theories differ in their predictions on whether increasing population density leads to individual adjustments of survival and reproductive output or to dominance and monopolization of resources. Here, we use a natural experiment to examine which factors limit population growth in the only remaining population of the endangered pale-headed brush finch (Atlapetes pallidiceps). For three distinct phases (a phase of population suppression, 2001-2002; expansion due to conservation management, 2003-2008; and equilibrium phase, 2009-2014), we estimated demographic parameters with an integrated population model using population size, the proportion of successfully breeding pairs and their productivity, territory size, and mark-recapture data of adult birds...
November 21, 2016: Oecologia
https://www.readbyqxmd.com/read/27859692/louse-borne-relapsing-fever-in-finland-in-two-asylum-seekers-from-somalia
#18
Jukka Hytönen, Tamim Khawaja, Juha O Grönroos, Anna Jalava, Seppo Meri, Jarmo Oksi
We report two cases of louse-borne relapsing fever (LBRF) in young Somali asylum seekers having recently arrived to Finland. They had sought medical attention for a febrile illness. Blood smears were examined for suspected malaria, but instead, spirochete shaped bacteria were observed. The bacteria were confirmed as Borrelia recurrentis by PCR and sequencing. The patients survived, but their treatment was complicated by Jarisch-Herxheimer reaction. We conclude that LBRF must be considered as a diagnostic option in febrile refugees also in the northernmost parts of Europe...
January 2017: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/27856057/mapping-the-birch-and-grass-pollen-seasons-in-the-uk-using-satellite-sensor-time-series
#19
Nabaz R Khwarahm, Jadunandan Dash, C A Skjøth, R M Newnham, B Adams-Groom, K Head, Eric Caulton, Peter M Atkinson
Grass and birch pollen are two major causes of seasonal allergic rhinitis (hay fever) in the UK and parts of Europe affecting around 15-20% of the population. Current prediction of these allergens in the UK is based on (i) measurements of pollen concentrations at a limited number of monitoring stations across the country and (ii) general information about the phenological status of the vegetation. Thus, the current prediction methodology provides information at a coarse spatial resolution only. Most station-based approaches take into account only local observations of flowering, while only a small number of approaches take into account remote observations of land surface phenology...
February 1, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/27851258/1623-common-hurdles-in-the-postoperative-management-of-a-patient-with-a-total-artificial-heart
#20
Marissa Mery, Siavosh Saatee, Sonia Nhieu
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
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