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https://www.readbyqxmd.com/read/28436646/filaments-with-affinity-binding-and-wet-strength-can-be-achieved-by-spinning-bifunctional-cellulose-nanofibrils
#1
Maija Vuoriluoto, Hannes Orelma, Meri Johanna Lundahl, Maryam Borghei, Orlando J Rojas
We demonstrate benzophenone (BP) conjugation via amine-reactive esters onto oxidized cellulosic fibers that were used as precursors, after microfluidization, of photo-active cellulose nanofibrils (CNF). From these fibrils, cellulose I filaments were synthesized by hydrogel spinning in an anti-solvent followed by fast bi-radical UV crosslinking. As a result, the BP-CNF filaments developed a wet tensile strength of up to ~105 MPa (a remarkable retention of ~80% of the dry strength). Thus, the principal limitation of these emerging materials was resolved (< 0...
April 24, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28431553/long-working-hours-in-the-healthcare-system-of-the-belo-horizonte-municipality-brazil-a-population-based-cross-sectional-survey
#2
Juliana M Andrade, Ada A Assunção, Mery N S Abreu
BACKGROUND: Health personnel are key players in developing and improving healthcare systems, caring for individuals and their communities, and helping improve quality of life. However, these professionals are often exposed to long working hours because of the pressing need for their services at potentially any time of day. The long working hours they endure are a major risk factor for both acute and chronic health problems. The present study aimed to analyze occurrences of long working hours and their association with individual characteristics and employment factors among workers in the municipal healthcare system in Belo Horizonte, Brazil...
April 21, 2017: Human Resources for Health
https://www.readbyqxmd.com/read/28427233/assessment-of-the-interlaboratory-variability-and-robustness-of-jak2v617f-mutation-assays-a-study-involving-a-consortium-of-19-italian-laboratories
#3
Margherita Perricone, Francesca Palandri, Emanuela Ottaviani, Mario Angelini, Laura Bagli, Enrica Bellesia, Meris Donati, Donato Gemmati, Patrizia Zucchini, Stefania Mancini, Valentina Marchica, Serena Trubini, Giovanna De Matteis, Silvia Di Zacomo, Mosè Favarato, Annamaria Fioroni, Caterina Bolzonella, Giorgia Maccari, Filippo Navaglia, Daniela Gatti, Luisa Toffolatti, Linda Orlandi, Vèronique Laloux, Marco Manfrini, Piero Galieni, Barbara Giannini, Alessia Tieghi, Sara Barulli, Maria Luisa Serino, Monica Maccaferri, Anna Rita Scortechini, Nicola Giuliani, Daniele Vallisa, Massimiliano Bonifacio, Patrizia Accorsi, Cristina Salbe, Vinicio Fazio, Milena Gusella, Eleonora Toffoletti, Marzia Salvucci, Mirija Svaldi, Filippo Gherlinzoni, Francesca Cassavia, Francesco Orsini, Giovanni Martinelli
To date, a plenty of techniques for the detection of JAK2V617F is used over different laboratories, with substantial differences in specificity and sensitivity. Therefore, to provide reliable and comparable results, the standardization of molecular techniques is mandatory.A network of 19 centers was established to 1) evaluate the inter- and intra-laboratory variability in JAK2V617F quantification, 2) identify the most robust assay for the standardization of the molecular test and 3) allow consistent interpretation of individual patient analysis results...
March 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/28420540/what-do-we-mean-when-we-talk-about-the-triple-aim-a-systematic-review-of-evolving-definitions-and-adaptations-of-the-framework-at-the-health-system-level
#4
REVIEW
Gustavo Mery, Shilpi Majumder, Adalsteinn Brown, Mark J Dobrow
Notwithstanding important contributions of the Triple Aim, uncritical enthusiasm regarding the implications of the framework may be leading to inconsistent use, particularly when applied at the health system level, which goes beyond the original positioning of the framework as a strategic organizing principle to guide improvement initiatives at the organizational or local community level. We systematically identified uses of the Triple Aim that extended beyond its original intention to focus on uses at the whole health system level, to assess convergence and divergence with the original definition...
April 1, 2017: Health Policy
https://www.readbyqxmd.com/read/28412492/element-variability-in-lacustrine-systems-of-terra-nova-bay-antarctica-and-concentration-evolution-in-surface-waters
#5
Isabella Zelano, Mery Malandrino, Agnese Giacomino, Sandro Buoso, Eleonora Conca, Yann Sivry, Marc Benedetti, Ornella Abollino
Major, minor and trace elements were determined in freshwater of lacustrine systems in Terra Nova Bay, along Victoria Land coast, Antarctica, as well as in algae and mosses. The samples were collected during some of the sampling campaigns between 2007 and 2011 (and the one of 2002) within the framework of the Italian National Program of Research in Antarctica (PNRA). Data were processed with chemometric techniques. Results showed that elements typically considered as potential anthropogenic pollutants (e.g...
April 4, 2017: Chemosphere
https://www.readbyqxmd.com/read/28398524/networking-for-ovarian-rare-tumors-a-significant-breakthrough-improving-disease-management
#6
N Chiannilkulchai, P Pautier, C Genestie, A S Bats, M C Vacher-Lavenu, M Devouassoux-Shisheboran, I Treilleux, A Floquet, S Croce, G Ferron, E Mery, C Pomel, F Penault-Llorca, C Lefeuvre-Plesse, S Henno, E Leblanc, A S Lemaire, G Averous, J E Kurtz, I Ray-Coquard
Background: Rare ovarian tumors represent >20% of all ovarian cancers. Given the rarity of these tumors, natural history, prognostic factors are not clearly identified. The extreme variability of patients (age, histological subtypes, stage) induces multiple and complex therapeutic strategies. Methods: Since 2011, a national network with a dedicated system for referral, up to 22 regional and three national reference centers (RC) has been supported by the French National Cancer Institute (INCa)...
April 7, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28398346/chemical-microenvironments-and-single-cell-carbon-and-nitrogen-uptake-in-field-collected-colonies-of-trichodesmium-under-different-pco2
#7
Meri J Eichner, Isabell Klawonn, Samuel T Wilson, Sten Littmann, Martin J Whitehouse, Matthew J Church, Marcel Mm Kuypers, David M Karl, Helle Ploug
Gradients of oxygen (O2) and pH, as well as small-scale fluxes of carbon (C), nitrogen (N) and O2 were investigated under different partial pressures of carbon dioxide (pCO2) in field-collected colonies of the marine dinitrogen (N2)-fixing cyanobacterium Trichodesmium. Microsensor measurements indicated that cells within colonies experienced large fluctuations in O2, pH and CO2 concentrations over a day-night cycle. O2 concentrations varied with light intensity and time of day, yet colonies exposed to light were supersaturated with O2 (up to ~200%) throughout the light period and anoxia was not detected...
April 11, 2017: ISME Journal
https://www.readbyqxmd.com/read/28390744/atrial-fibrillation-in-cancer-patients-hindsight-insight-and-foresight
#8
Benoîte Mery, Jean-Baptiste Guichard, Jean-Baptiste Guy, Alexis Vallard, Jean-Claude Barthelemy, Antoine Da Costa, Nicolas Magné, Laurent Bertoletti
An increase of atrial fibrillation (AF) incidence in cancer patients has recently been pointed out, with complex interrelationships between these two entities on top of surgery factors. Most of present knowledge comes from retrospective studies or data from registries but the underlying mechanisms of the association between atrial fibrillation and cancer are still unclear. An increased risk of AF in cancer patients could represent a major public health problem although scarce information is available for the challenging management of such patients with distinctive features, especially in terms of antithrombotic therapy...
April 5, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28365206/prevalence-and-incidence-density-of-unavoidable-pressure-ulcers-in-elderly-patients-admitted-to-medical-units
#9
Alvisa Palese, Barbara Trevisani, Annamaria Guarnier, Paolo Barelli, Paola Zambiasi, Elisabetta Allegrini, Letizia Bazoli, Paola Casson, Meri Marin, Marisa Padovan, Michele Picogna, Patrizia Taddia, Daniele Salmaso, Paolo Chiari, Oliva Marognolli, Canzan Federica, Luisa Saiani, Elisa Ambrosi
To describe the prevalence and incidence density of hospital-acquired unavoidable pressure sores among patients aged ≥65 years admitted to acute medical units. A secondary analysis of longitudinal study data collected in 2012 and 2013 from 12 acute medical units located in 12 Italian hospitals was performed. Unavoidable pressure ulcers were defined as those that occurred in haemodynamically unstable patients, suffering from cachexia and/or terminally ill and were acquired after hospital admission. Data at patient and at pressure ulcer levels were collected on a daily basis at the bedside by trained researchers...
March 23, 2017: Journal of Tissue Viability
https://www.readbyqxmd.com/read/28359576/teaching-congenital-heart-disease-a-new-era
#10
EDITORIAL
Ziv Beckerman, Carlos M Mery
No abstract text is available yet for this article.
March 9, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28353265/derivation-of-human-embryonic-stem-cells
#11
Jeremy M Crook, Lucy Kravets, Teija Peura, Meri T Firpo
Embryonic stem cells (ESCs) represent a mainstay for pluripotent stem cell research and development (R&D) and provide tangible opportunities for clinical translation including cell therapies and drug discovery. Moreover, in spite of the discovery of induced pluripotent stem cells (iPSCs), ESCs are an essential reference point, against which other pluripotent cells are compared. Hence, there is an ongoing need to derive and bank quality-controlled research-grade and clinical-grade ESC lines using established and standardized methods...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28340725/biomonitored-uhplc-esi-qtof-ms-2-and-hplc-uv-thermostability-study-of-the-aerial-parts-of-sphagneticola-trilobata-l-pruski-asteraceae
#12
Keline Lang, Jessica Corrêa, Fellippe Wolff, Gislaine Franciele da Silva, Angela Malheiros, Valdir Cechinel Filho, Ruth Meri Lucinda Silva, Nara Lins Meira Quintão, Louis P Sandjo, Tiago J Bonomini, Tania Mari Bellé Bresolin
As the temperature of extraction and processing could impact the biological effects of herbal extracts, which have wide chemical diversity, the aim of this work were to investigate the thermostability of herbal derivatives of the aerial parts of Sphagneticola trilobata, a reputed medicinal plant; to biomonitor its oral anti-hyperalgesic effect; and to elucidate the degradation pathways of the major components by UHPLC-ESI-QTOF-MS. The lipophilic markers (kaurenoic acid-KA) and hydrophilic markers [chlorogenic acids; measured as total phenolic compounds (PC), expressed in caffeic acid] were also monitored through a validated HPLC-UV methodology, suitable for quality control and stability studies...
May 15, 2017: Talanta
https://www.readbyqxmd.com/read/28326678/rational-engineering-of-bodipy-bridged-trisindole-derivatives-for-solar-cell-applications
#13
Nicolas Leclerc, Ibrahim Bulut, Quentin Huaulmé, Antoine Mirloup, Patricia Chávez, Sadiara Fall, Anne Hébraud, Stéphane Méry, Benoit Heinrich, Thomas Heiser, Patrick Lévêque
Boron dipyrromethene (Bodipy) are known to be efficient photon harvesting chromophores. However, their study as active materials in bulk heterojunction (BHJ) solar cells is still scarce. In this paper, we developed new synthetic ways to design original Bodipy-based dumbbell-shape molecules, including a first 2,3,5,6-tetravinyl aromatic Bodipy molecule. We demonstrated that high fill factors can be obtained in BHJ solar cells when blended with a fullerene derivative, leading to a new Bodipy-based record power conversion efficiency of 5...
March 21, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28326488/is-lmwh-sufficient-for-anticoagulant-prophylaxis-in-bariatric-surgery-prospective-study
#14
Farraj Moaad, Bramnik Zakhar, Kvasha Anton, Merie Moner, Sbeit Wisam, Farraj Safy, Waksman Igor
BACKGROUND: The objective of this study was to evaluate the coagulation profile by thromboelastography in morbidly obese patients who undergo bariatric surgery. Morbid obesity entails increased risk for thromboembolic events. There is no clear protocol for thromboembolic prophylaxis, regarding timing and length of treatment, in bariatric surgery. Thromboelastography provides data on a coagulation process from creation of the clot until the fibrinolysis. METHODS: Ninety-three morbidly obese patients were prospectively recruited within a 2-year period...
March 22, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28325258/quality-of-reporting-in-oncology-studies-a-systematic-analysis-of-literature-reviews-and-prospects
#15
REVIEW
Romain Rivoirard, Aurélie Bourmaud, Mathieu Oriol, Fabien Tinquaut, Benoîte Méry, Julien Langrand-Escure, Alexis Vallard, Pierre Fournel, Nicolas Magné, Franck Chauvin
The present review gives an overview of systematic reviews published in peer reviewed Journals analysing quality of reporting in oncology studies. PUBMED and Cochrane library were searched to identify systematic reviews assessing quality of reporting for randomized controlled trials (RCTs) and observational studies (OBS). Recommendations and primary endpoints used to assess the quality of reporting were described. Intrinsic quality of reporting was analyzed using an Overall Quality Score for literature Reviews (OQSR)...
April 2017: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/28322525/-la-percezione-del-rapporto-ambiente-salute-secondo-i-dati-della-sorveglianza-progressi-delle-aziende-sanitarie-per-la-salute-in-italia-passi
#16
Letizia Sampaolo, Giulia Tommaso, Bianca Gherardi, Giuliano Carrozzi, Anna Freni Sterrantino, Marta Ottone, Carlo Alberto Goldoni, Nicoletta Bertozzi, Meri Scaringi, Lara Bolognesi, Maria Masocco, Stefania Salmaso, Paolo Lauriola
"OBJECTIVES: to identify groups of people in relation to the perception of environmental risk and to assess the main characteristics using data collected in the environmental module of the surveillance network Italian Behavioral Risk Factor Surveillance System (PASSI). METHODS: perceptive profiles were identified using a latent class analysis; later they were included as outcome in multinomial logistic regression models to assess the association between environmental risk perception and demographic, health, socio-economic and behavioural variables...
January 2017: Epidemiologia e Prevenzione
https://www.readbyqxmd.com/read/28322200/complement-component-c3-and-complement-factor-b-promote-growth-of-cutaneous-squamous-cell-carcinoma
#17
Pilvi Riihilä, Liisa Nissinen, Mehdi Farshchian, Markku Kallajoki, Atte Kivisaari, Seppo Meri, Reidar Grénman, Sirkku Peltonen, Juha Peltonen, Taina Pihlajaniemi, Ritva Heljasvaara, Veli-Matti Kähäri
Cutaneous squamous cell carcinoma (cSCC) is one of the most common metastatic skin cancers with increasing incidence. We examined the roles of complement component C3 and complement factor B (CFB) in the growth of cSCC. Analysis of cSCC cell lines (n = 8) and normal human epidermal keratinocytes (n = 11) with real-time quantitative PCR and Western blotting revealed up-regulation of C3 and CFB expression in cSCC cells. Immunohistochemical staining revealed stronger tumor cell-specific labeling for C3 and CFB in invasive cSCCs (n = 71) and recessive dystrophic epidermolysis bullosa-associated cSCCs (n = 11) than in cSCC in situ (n = 69), actinic keratoses (n = 63), and normal skin (n = 5)...
March 16, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/28306198/plasma-levels-of-plasminogen-activator-inhibitor-1-and-bleeding-phenotype-in-patients-with-von-willebrand-disease
#18
S Abdul, J Boender, J J M C Malfliet, J Eikenboom, K Fijn van Draat, E P Mauser-Bunschoten, K Meijer, J de Meris, B A P Laros-van Gorkom, J G van der Bom, F W G Leebeek, D C Rijken, S Uitte de Willige
INTRODUCTION: von Willebrand disease (VWD) is the most common inherited bleeding disorder. In VWD patients, large variations in bleeding tendency are observed, which cannot be completely explained by the variation in von Willebrand factor levels or activities. Thus, there must be additional factors, for instance, changes in fibrinolysis that have an effect on the variation in bleeding tendency in VWD patients. AIM: To investigate whether plasminogen activator inhibitor-1 (PAI-1) level influences the variation in bleeding tendency in VWD patients...
March 17, 2017: Haemophilia: the Official Journal of the World Federation of Hemophilia
https://www.readbyqxmd.com/read/28288297/early-rehabilitation-of-incisors-with-dentinogenesis-imperfecta-type-ii-case-report
#19
Ana Paula Ca Beltrame, Maíra Mery Rosa, Ricardo At Noschang, Izabel Cs Almeida
Dentinogenesis imperfecta is an phenotypic alteration in the formation of the organic matrix. It causes the rapid and progressive wear of tooth structure, which may compromise tooth function and aesthetics. This is a case of a 1y, 8m-old child with dentinogenesis imperfecta. All teeth presented with an opalescent appearance and grayish color hue. Compromised structural integrity was noted as excessive wear and fracturing of the enamel from the dentin layer. With low doses of midazolam (oral) and chloral hydrate (rectal) administration, in a hospital environment, sedation was used to aid full mouth rehabilitation...
2017: Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/28287899/retinal-vascular-caliber-and-kidney-function-in-children-and-adolescents-with-type-1-diabetes
#20
Stuart Keel, Catherine Itsiopoulos, Konstandina Koklanis, Meri Vukicevic, Fergus Cameron, Laima Brazionis
PURPOSE: To evaluate the relationship between retinal vascular caliber and kidney function in a cohort of Australian children and adolescents with type 1 diabetes. METHODS: This was a cross-sectional study of 483 children and adolescents with type 1 diabetes, aged 7-18 years. An audit of medical files of participants who attended the Royal Children's Hospital, Melbourne, between January 2009 and March 2014 was performed. Albumin to creatinine ratio (ACR) was acquired through spot urine samples and microalbuminuria was classified as ACR >3...
March 13, 2017: Ophthalmic Epidemiology
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