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https://www.readbyqxmd.com/read/28803155/assisted-phytoremediation-of-a-multi-contaminated-soil-investigation-on-arsenic-and-lead-combined-mobilization-and-removal
#1
Meri Barbafieri, Francesca Pedron, Gianniantonio Petruzzelli, Irene Rosellini, Elisabetta Franchi, Roberto Bagatin, Marco Vocciante
The removal of contaminants from an earthy matrix by phytoremediation requires the selection of appropriate plant species and a suitable strategy to be effective. In order to set up an assisted phytoremediation intervention related to a disused industrial site affected by an arsenic and lead complex contamination, an extensive experimental investigation on micro and mesocosm scale has been conducted. Particular attention was given to the choice of plant species: using crop plants (Lupinus albus, Helianthus annuus and Brassica juncea) a series of parallel test campaigns have been realized to investigate different scenarios for the reclamation...
August 10, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28789716/in-vitro-antileishmanial-activity-and-iron-superoxide-dismutase-inhibition-of-arylamine-mannich-base-derivatives
#2
Alvaro Martin-Montes, Mery Santivañez-Veliz, Elsa Moreno-Viguri, Rubén Martín-Escolano, Carmen Jiménez-Montes, Catalina Lopez-Gonzalez, Clotilde Marín, Carmen Sanmartín, Ramón Gutiérrez Sánchez, Manuel Sánchez-Moreno, Silvia Pérez-Silanes
Leishmaniasis is one of the world's most neglected diseases, and it has a worldwide prevalence of 12 million. There are no effective human vaccines for its prevention, and treatment is hampered by outdated drugs. Therefore, research aiming at the development of new therapeutic tools to fight leishmaniasis remains a crucial goal today. With this purpose in mind, we present 20 arylaminoketone derivatives with a very interesting in vitro and in vivo efficacy against Trypanosoma cruzi that have now been studied against promastigote and amastigote forms of Leishmania infantum, Leishmania donovani and Leishmania braziliensis strains...
August 9, 2017: Parasitology
https://www.readbyqxmd.com/read/28777221/characterization-of-resolution-sensitivity-and-shielding-of-a-gamma-probe-for-sentinel-lymph-node-localization-an-experimental-study
#3
Emerson N Itikawa, Leonardo A Santos, Ana C Trevisan, Felipe A Pitella, Mery Kato, Eder R Moraes, Lauro Wichert-Ana
OBJECTIVE: The aim of this study was to evaluate angular, spatial, and energy resolution, sensitivity, and shielding of a gamma-probe. MATERIALS AND METHODS: The EUROPROBE II gamma-probe (EuroRad) with sources of technetium-99m was assessed according to NEMA NU-3-2004. Resolution tests were evaluated considering the full width at half maximum (FWHM). The following parameters were evaluated: angular resolution in air, spatial resolution with a scattering medium and in air, energy resolution, and sensitivity and shielding...
August 3, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28775335/nubbedb-an-updated-database-to-uncover-chemical-and-biological-information-from-brazilian-biodiversity
#4
Alan C Pilon, Marilia Valli, Alessandra C Dametto, Meri Emili F Pinto, Rafael T Freire, Ian Castro-Gamboa, Adriano D Andricopulo, Vanderlan S Bolzani
The intrinsic value of biodiversity extends beyond species diversity, genetic heritage, ecosystem variability and ecological services, such as climate regulation, water quality, nutrient cycling and the provision of reproductive habitats it is also an inexhaustible source of molecules and products beneficial to human well-being. To uncover the chemistry of Brazilian natural products, the Nuclei of Bioassays, Ecophysiology and Biosynthesis of Natural Products Database (NuBBEDB) was created as the first natural product library from Brazilian biodiversity...
August 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28755717/a-method-for-examining-temporal-changes-in-cyanobacterial-harmful-algal-bloom-spatial-extent-using-satellite-remote-sensing
#5
Erin A Urquhart, Blake A Schaeffer, Richard P Stumpf, Keith A Loftin, P Jeremy Werdell
Cyanobacterial harmful algal blooms (CyanoHAB) are thought to be increasing globally over the past few decades, but relatively little quantitative information is available about the spatial extent of blooms. Satellite remote sensing provides a potential technology for identifying cyanoHABs in multiple water bodies and across geo-political boundaries. An assessment method was developed using MEdium Resolution Imaging Spectrometer (MERIS) imagery to quantify cyanoHAB surface area extent, transferable to different spatial areas, in Florida, Ohio, and California for the test period of 2008 to 2012...
July 2017: Harmful Algae
https://www.readbyqxmd.com/read/28750236/development-validation-and-application-of-a-gc-ms-method-for-the-simultaneous-detection-and-quantification-of-neutral-lipid-species-in-trypanosoma-cruzi
#6
Mery Santivañez-Veliz, Elsa Moreno-Viguri, Silvia Pérez-Silanes, Javier Varela, Hugo Cerecetto, Mercedes González, Elena Lizarraga
The development and validation of an analytical method for the simultaneous analysis of five neutral lipids in Trypanosoma cruzi epimastigotes by GC-MS is presented in this study. The validated method meets all validation parameters for all components and the chromatographic conditions have been optimized during its development. This analytical method has demonstrated good selectivity, accuracy, within-day precision, recovery and linearity in each of the established ranges. In addition, detection and quantification limits for squalene, cholesterol, ergosterol and lanosterol have been improved and it is worth highlighting the fact that this is the first time that squalene-2,3-epoxide validation data have been reported...
July 19, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28737022/anatomic-types-of-anomalous-aortic-origin-of-a-coronary-artery-a-pictorial-summary
#7
Hitesh Agrawal, Carlos M Mery, Rajesh Krishnamurthy, Silvana Molossi
Anomalous aortic origin of a coronary artery is a congenital abnormality of the origin or course of a coronary artery that arises from the aorta. As commonly seen in congenital heart disease, a wide spectrum of anatomic variability is seen and hence, it is important for clinicians to document the precise anatomy and course of the anomalous vessel. This article describes coronary artery nomenclature using computerized tomography angiography and virtual angioscopy. These details are important for decision making, useful for surgical planning, and may have prognostic implications...
July 24, 2017: Congenital Heart Disease
https://www.readbyqxmd.com/read/28726769/activity-dependent-feedback-inhibition-may-maintain-head-direction-signals-in-mouse-presubiculum
#8
Jean Simonnet, Mérie Nassar, Federico Stella, Ivan Cohen, Bertrand Mathon, Charlotte N Boccara, Richard Miles, Desdemona Fricker
Orientation in space is represented in specialized brain circuits. Persistent head direction signals are transmitted from anterior thalamus to the presubiculum, but the identity of the presubicular target neurons, their connectivity and function in local microcircuits are unknown. Here, we examine how thalamic afferents recruit presubicular principal neurons and Martinotti interneurons, and the ensuing synaptic interactions between these cells. Pyramidal neuron activation of Martinotti cells in superficial layers is strongly facilitating such that high-frequency head directional stimulation efficiently unmutes synaptic excitation...
July 20, 2017: Nature Communications
https://www.readbyqxmd.com/read/28717385/changes-in-diet-associated-with-cancer-an-evolutionary-perspective
#9
Frédéric Thomas, Sophie Rome, Frédéric Mery, Erika Dawson, Jacques Montagne, Peter A Biro, Christa Beckmann, François Renaud, Robert Poulin, Michel Raymond, Beata Ujvari
Changes in diet are frequently correlated with the occurrence and progression of malignant tumors (i.e., cancer) in both humans and other animals, but an integrated conceptual framework to interpret these changes still needs to be developed. Our aim is to provide a new perspective on dietary changes in tumor-bearing individuals by adapting concepts from parasitology. Dietary changes may occur alongside tumor progression for several reasons: (i) as a pathological side effect with no adaptive value, (ii) as the result of self-medication by the host to eradicate the tumor and/or to slow down its progression, (iii) as a result of host manipulation by the tumor that benefits its progression, and finally (iv) as a host tolerance strategy, to alleviate and repair damages caused by tumor progression...
August 2017: Evolutionary Applications
https://www.readbyqxmd.com/read/28709660/effect-of-gastrointestinal-malformations-on-the-outcomes-of-patients-with-congenital-heart-disease
#10
Carlos M Mery, Luis E De León, J Rubén Rodriguez, R Michael Nieto, Wei Zhang, Iki Adachi, Jeffrey S Heinle, Lauren C Kane, E Dean McKenzie, Charles D Fraser
BACKGROUND: The goal of this study was to assess the effect of associated gastrointestinal malformations (GI) on the outcomes of patients undergoing congenital heart operations. METHODS: Neonates and infants with thoracic (esophageal atresia, tracheoesophageal fistula) and abdominal (duodenal stenosis/atresia, imperforate anus, Hirschsprung disease) GI malformations undergoing congenital heart operations between 1995 and 2015 were included. Two control groups were created, one for each group...
July 11, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28700750/correction-genotypic-and-phenotypic-diversity-of-lactobacillus-rhamnosus-clinical-isolates-their-comparison-with-strain-gg-and-their-recognition-by-complement-system
#11
Eija Nissilä, François P Douillard, Jarmo Ritari, Lars Paulin, Hanna M Järvinen, Pia Rasinkangas, Karita Haapasalo, Seppo Meri, Hanna Jarva, Willem M de Vos
[This corrects the article DOI: 10.1371/journal.pone.0176739.].
2017: PloS One
https://www.readbyqxmd.com/read/28670826/current-practices-are-variable-in-the-evaluation-and-management-of-patients-with-anomalous-aortic-origin-of-a-coronary-artery-results-of-a-survey
#12
Hitesh Agrawal, Carlos M Mery, Patrick E Day, S Kristen Sexson Tejtel, E Dean McKenzie, Charles D Fraser, Athar M Qureshi, Silvana Molossi
BACKGROUND: Anomalous aortic origin of a coronary artery (AAOCA) is the second leading cause of sudden cardiac death in young athletes in the USA. Long-term outcome data for these patients are lacking to date. There is insufficient knowledge on the best approach to these patients and they are managed in a nonuniform manner. METHODS: An online survey of 15 questions regarding management of AAOCA was sent out to 198 cardiac healthcare providers. The goal was to define gaps in knowledge to justify a dedicated scientific forum for discussion of AAOCA...
July 2, 2017: Congenital Heart Disease
https://www.readbyqxmd.com/read/28668353/salsa-a-dance-on-a-slippery-floor-with-changing-partners
#13
M P Reichhardt, U Holmskov, S Meri
It is becoming increasingly clear that the connections between our immune system and the microbiota colonizing us have a tremendous impact on human health. A number of innate molecular defence mechanisms cooperate to selectively target unwanted microorganisms at the mucosal surfaces. Amongst others these include the complement system, IgA and the SALSA molecule. The salivary scavenger and agglutinin (SALSA), also known as deleted in malignant brain tumors 1 (DMBT1), salivary agglutinin (SAG) or gp340 is a multifunctional molecule with important functions in innate immunity, inflammation and epithelial homeostasis...
June 28, 2017: Molecular Immunology
https://www.readbyqxmd.com/read/28658260/spatiotemporal-variability-and-environmental-factors-of-harmful-algal-blooms-habs-over-western-lake-erie
#14
Di Tian, Gengxin Xie, Jing Tian, Kuo-Hsin Tseng, C K Shum, Jiyoung Lee, Song Liang
Over the past decades, numerous studies have been carried out in understanding causes of Harmful Algal Blooms (HABs) and their dynamics, yielding great knowledge in this field. Lake Erie, the fourth-largest lake of the five Great Lake, is among those highly vulnerable to the impacts of HABs and has received substantial attention from the public, water management sectors, and academic field. Building upon previous work, this study aims to characterize spatiotemporal variability of Chlorophyll a (Chl-a), which is an important indicator of HABs, and to explore relative importance of environmental factors associated with HABs in the west Lake Erie...
2017: PloS One
https://www.readbyqxmd.com/read/28655446/cerebral-autoregulation-making-sense-of-the-nonsensical
#15
EDITORIAL
Ken M Brady, Carlos M Mery
No abstract text is available yet for this article.
May 31, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28652462/protective-low-frequency-variants-for-preeclampsia-in-the-fms-related-tyrosine-kinase-1-gene-in-the-finnish-population
#16
A Inkeri Lokki, Emma Daly, Michael Triebwasser, Mitja I Kurki, Elisha D O Roberson, Paavo Häppölä, Kirsi Auro, Markus Perola, Seppo Heinonen, Eero Kajantie, Juha Kere, Katja Kivinen, Anneli Pouta, Jane E Salmon, Seppo Meri, Mark Daly, John P Atkinson, Hannele Laivuori
Preeclampsia is a common pregnancy-specific vascular disorder characterized by new-onset hypertension and proteinuria during the second half of pregnancy. Predisposition to preeclampsia is in part heritable. It is associated with an increased risk of cardiovascular disease later in life. We have sequenced 124 candidate genes implicated in preeclampsia to pinpoint genetic variants contributing to predisposition to or protection from preeclampsia. First, targeted exomic sequencing was performed in 500 preeclamptic women and 190 controls from the FINNPEC cohort (Finnish Genetics of Preeclampsia Consortium)...
August 2017: Hypertension
https://www.readbyqxmd.com/read/28644649/role-of-a-neighbor-ion-in-the-fragmentation-dynamics-of-covalent-molecules
#17
A Méry, A N Agnihotri, J Douady, X Fléchard, B Gervais, S Guillous, W Iskandar, E Jacquet, J Matsumoto, J Rangama, F Ropars, C P Safvan, H Shiromaru, D Zanuttini, A Cassimi
Fragmentation of molecular nitrogen dimers (N_{2})_{2} induced by collision with low energy 90 keV Ar^{9+} ions is studied to evidence the influence of a molecular environment on the fragmentation dynamics of N_{2} cations. Following the capture of three or four electrons from the dimer, the three-body N_{2}^{+}+N^{m+}+N^{n+} [with (m,n)=(1,1) or (1, 2)] fragmentation channels provide clean experimental cases where molecular fragmentation may occur in the presence of a neighbor molecular cation. The effect of the environment on the fragmentation dynamics within the dimer is investigated through the comparison of the kinetic energy release (KER) spectra for these three-body channels and for isolated N_{2}^{(m+n)+} monomer cations...
June 9, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28619621/immunohistochemical-evaluation-of-two-antibodies-against-pd-l1-and-prognostic-significance-of-pd-l1-expression-in-epithelioid-peritoneal-malignant-mesothelioma-a%C3%A2-renape-study
#18
S Valmary-Degano, P Colpart, L Villeneuve, F Monnien, L M'Hamdi, G Lang Averous, M Capovilla, F Bibeau, M-H Laverriere, V Verriele-Beurrier, H Ben Rejeb, P Dartigues, J Hommell-Fontaine, F-N Gilly, S Isaac, E Mery
BACKGROUND: Epithelioid peritoneal malignant mesothelioma (EPMM) is the most common subtype of this aggressive tumor. We compared two antibodies against PD-L1, a recent theranostic biomarker, and evaluated the prognostic value of PD-L1 expression by mesothelial and immune cells in EPMM. METHODS: Immunohistochemistry was performed on 45 EPMM. Clinical and pathological data were extracted from the RENAPE database. Using E1L3N and SP142 clones, inter-observer agreement, PD-L1 expression by mesothelial and immune cells and inter-antibody agreement were evaluated...
May 18, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28614593/inconsistencies-of-interannual-variability-and-trends-in-long-term-satellite-leaf-area-index-products
#19
Chongya Jiang, Youngryel Ryu, Hongliang Fang, Ranga Myneni, Martin Claverie, Zaichun Zhu
Understanding the long-term performance of global satellite leaf area index (LAI) products is important for global change research. However, few effort has been devoted to evaluating the long-term time series consistencies of LAI products. This study compared four long-term LAI products (GLASS, GLOBMAP, LAI3g, and TCDR) in terms of trends, interannual variabilities and uncertainty variations from 1982 through 2011. This study also used four ancillary LAI products (GEOV1, MERIS, MODIS C5, and MODIS C6) from 2003 through 2011 to help clarify the performances of the four long-term LAI products...
June 14, 2017: Global Change Biology
https://www.readbyqxmd.com/read/28611769/analysis-of-complement-c3-gene-reveals-susceptibility-to-severe-preeclampsia
#20
A Inkeri Lokki, Tea Kaartokallio, Ville Holmberg, Päivi Onkamo, Lotta L E Koskinen, Päivi Saavalainen, Seppo Heinonen, Eero Kajantie, Juha Kere, Katja Kivinen, Anneli Pouta, Pia M Villa, Leena Hiltunen, Hannele Laivuori, Seppo Meri
Preeclampsia (PE) is a common vascular disease of pregnancy with genetic predisposition. Dysregulation of the complement system has been implicated, but molecular mechanisms are incompletely understood. In this study, we determined the potential linkage of severe PE to the most central complement gene, C3. Three cohorts of Finnish patients and controls were recruited for a genetic case-control study. Participants were genotyped using Sequenom genotyping and Sanger sequencing. Initially, we studied 259 Finnish patients with severe PE and 426 controls from the Southern Finland PE and the Finnish population-based PE cohorts...
2017: Frontiers in Immunology
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