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https://www.readbyqxmd.com/read/28619621/immunohistochemical-evaluation-of-two-antibodies-against-pd-l1-and-prognostic-significance-of-pd-l1-expression-in-epithelioid-peritoneal-malignant-mesothelioma-a%C3%A2-renape-study
#1
S Valmary-Degano, P Colpart, L Villeneuve, F Monnien, L M'Hamdi, G Lang Averous, M Capovilla, F Bibeau, M-H Laverriere, V Verriele-Beurrier, H Ben Rejeb, P Dartigues, J Hommell-Fontaine, F-N Gilly, S Isaac, E Mery
BACKGROUND: Epithelioid peritoneal malignant mesothelioma (EPMM) is the most common subtype of this aggressive tumor. We compared two antibodies against PD-L1, a recent theranostic biomarker, and evaluated the prognostic value of PD-L1 expression by mesothelial and immune cells in EPMM. METHODS: Immunohistochemistry was performed on 45 EPMM. Clinical and pathological data were extracted from the RENAPE database. Using E1L3N and SP142 clones, inter-observer agreement, PD-L1 expression by mesothelial and immune cells and inter-antibody agreement were evaluated...
May 18, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28614593/inconsistencies-of-interannual-variability-and-trends-in-long-term-satellite-leaf-area-index-products
#2
Chongya Jiang, Youngryel Ryu, Hongliang Fang, Ranga Myneni, Martin Claverie, Zaichun Zhu
Understanding the long-term performance of global satellite leaf area index (LAI) products is important for global change research. However, few effort has been devoted to evaluating the long-term time series consistencies of LAI products. This study compared four long-term LAI products (GLASS, GLOBMAP, LAI3g, and TCDR) in terms of trends, interannual variabilities and uncertainty variations from 1982 through 2011. This study also used four ancillary LAI products (GEOV1, MERIS, MODIS C5, and MODIS C6) from 2003 through 2011 to help clarify the performances of the four long-term LAI products...
June 14, 2017: Global Change Biology
https://www.readbyqxmd.com/read/28611769/analysis-of-complement-c3-gene-reveals-susceptibility-to-severe-preeclampsia
#3
A Inkeri Lokki, Tea Kaartokallio, Ville Holmberg, Päivi Onkamo, Lotta L E Koskinen, Päivi Saavalainen, Seppo Heinonen, Eero Kajantie, Juha Kere, Katja Kivinen, Anneli Pouta, Pia M Villa, Leena Hiltunen, Hannele Laivuori, Seppo Meri
Preeclampsia (PE) is a common vascular disease of pregnancy with genetic predisposition. Dysregulation of the complement system has been implicated, but molecular mechanisms are incompletely understood. In this study, we determined the potential linkage of severe PE to the most central complement gene, C3. Three cohorts of Finnish patients and controls were recruited for a genetic case-control study. Participants were genotyped using Sequenom genotyping and Sanger sequencing. Initially, we studied 259 Finnish patients with severe PE and 426 controls from the Southern Finland PE and the Finnish population-based PE cohorts...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28609937/generic-reclassification-of-species-formerly-included-in-i-rhantus-i-dejean-coleoptera-dytiscidae-colymbetinae
#4
Michael Balke, Jiří Hájek, Lars Hendrich
A reclassification of several species traditionally included in Rhantus Dejean, 1833 is given: Nartus Zaitzev, 1907 is re-instated as genus with one species in the Nearctic and one in the Palaearctic region; two new genera are erected: Meri-diorhantus n. gen., with M. antarcticus (Germain, 1854) n. comb., M. calidus (Fabricius, 1792) n. comb., M. limbatus (Aubé, 1838) n. comb., M. orbignyi (Balke, 1992) n. comb., M. validus (Sharp, 1882) n. comb. in the Neotropical region (M. calidus also in the southern USA and along the eastern coast as far north as New York City), and the monotypic Caperhantus n...
April 26, 2017: Zootaxa
https://www.readbyqxmd.com/read/28602249/ten-year-survey-of-cyanobacterial-blooms-in-ohio-s-waterbodies-using-satellite-remote-sensing
#5
Tyler Gorham, Yuanyuan Jia, C K Shum, Jiyoung Lee
Cyanobacterial blooms are on the rise globally and are capable of adversely impacting human, animal, and ecosystem health. Blooms dominated by cyanobacteria species capable of toxin-production are commonly observed in eutrophic freshwater. The presence of cyanobacterial blooms in selected Ohio lakes, such as Lake Erie and Grand Lake St. Marys, has been well studied, but much less is known about the geographic distribution of these blooms across all of Ohio's waterbodies. We examined the geographic distribution of cyanobacterial blooms in Ohio's waterbodies from 2002 to 2011, using a nested semi-empirical algorithm and remotely sensed data from the Medium Resolution Imaging Spectrometer (MERIS) onboard the European Space Agency's Envisat...
June 2017: Harmful Algae
https://www.readbyqxmd.com/read/28599362/determination-of-phytoplankton-abundances-chlorophyll-a-in-the-optically-complex-inland-water-the-baltic-sea
#6
Daoxi Zhang, Samantha Lavender, Jan-Peter Muller, David Walton, Bengt Karlson, Johan Kronsell
A novel approach, termed Summed Positive Peaks (SPP), is proposed for determining phytoplankton abundances (Chlorophyll-a or Chl-a) and surface phytoplankton bloom extent in the optically complex Baltic Sea. The SPP approach is established on the basis of a baseline subtraction method using Rayleigh corrected top-of-atmosphere data from the Medium Resolution Imaging Spectrometer (MERIS) measurements. It calculates the reflectance differences between phytoplankton related signals observed in the MERIS red and near infrared (NIR) bands, such as sun-induced chlorophyll fluorescence (SICF) and the backscattering at 709nm, and considers the summation of the positive line heights for estimating Chl-a concentrations...
June 4, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28598033/decision-making-in-anomalous-aortic-origin-of-a-coronary-artery
#7
Carlos M Mery
Anomalous aortic origin of a coronary artery (AAOCA) is the second most common cause of sudden cardiac death (SCD) in young athletes in United States. The exact pathophysiological mechanisms of SCD are unknown. There is lack of long-term outcome data on repaired and unrepaired AAOCA and our current risk stratification scheme for these patients is suboptimal. These patients are evaluated in a nonuniform manner across institutions in United States, and even by different providers residing in the same institution...
June 9, 2017: Congenital Heart Disease
https://www.readbyqxmd.com/read/28593897/factors-that-influence-the-virological-response-in-patients-with-chronic-hepatitis-c-treated-with-pegylated-interferon-and-ribavirin
#8
Beti Todorovska, Nenad Joksimovic, Viktorija Caloska-Ivanova, Magdalena Dimitrova-Genadieva, Meri Trajkovska, Elena Curakova, Sanja Kiprijanovska, Beti Zafirova-Ivanovska, Vladimir Serafimoski
INTRODUCTION: The success of the antiviral treatment in patients with chronic hepatitis C depends on the factors related to the virus and the host. The aim of the study is the analysis of the antiviral therapy which is a combination of pegylated interferon and ribavirin, considering various factors that will identify the predictors of the sustained virological response. MATERIAL AND METHODS: This retrospective study included 226 patients, divided in two groups. Patients with sustained virological response and patients without sustained virological response were compared in terms of the following factors: genotype, viral load, gender, age, inflammatory and fibrotic changes in the liver, metabolic abnormalities, obesity and fatty liver...
March 1, 2017: Prilozi (Makedonska Akademija Na Naukite i Umetnostite. Oddelenie za Medicinski Nauki)
https://www.readbyqxmd.com/read/28593885/prognostic-factors-on-the-positivity-for-metastases-of-the-axillary-lymph-nodes-from-primary-breast-cancer
#9
Borislav Kondov, Goran Kondov, Zoran Spirovski, Zvonko Milenkovikj, Risto Colanceski, Gordana Petrusevska, Meri Pesevska
AIM: The aim of the study was to identify the impact of T stage, the presence of estrogen, progesterone, HER2neu receptors and the values of the Ki67 on the positivity for metastases of the axillary lymph nodes, from primary breast cancer. MATERIAL AND METHODS: 290 surgically treated patients for breast cancer were included in the study. All cases have been analyzed by standard histological analysis including microscopic analysis on standard H&E staining. For determining the molecular receptors - HER2neu, ER, PR, p53 and Ki67, immunostaining by PT LINK immunoperoxidase has been done...
March 1, 2017: Prilozi (Makedonska Akademija Na Naukite i Umetnostite. Oddelenie za Medicinski Nauki)
https://www.readbyqxmd.com/read/28592604/a-methodologic-framework-for-modeling-and-assessing-biomarkers-of-environmental-enteropathy-as-predictors-of-growth-in-infants-an-example-from-a-peruvian-birth-cohort
#10
Josh M Colston, Pablo Peñataro Yori, Elizabeth Colantuoni, Lawrence H Moulton, Ramya Ambikapathi, Gwenyth Lee, Dixner Rengifo Trigoso, Mery Siguas Salas, Margaret N Kosek
Background: Environmental enteropathy (EE) impairs the gut's absorptive capacity and immune function and causes decelerations in statural growth that manifest gradually over time.Objective: To illustrate an approach for assessing emerging biomarkers of EE, we separately assessed the associations between 3 such markers and subsequent nutritional status.Design: Stool samples were routinely collected between January 2010 and November 2014 from a cohort of 303 Peruvian infants and analyzed for concentrations of the biomarkers α-1-antitrypsin (AAT), myeloperoxidase, and neopterin...
June 7, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28591358/factor-associated-with-self-reported-work-related-musculoskeletal-disorders-in-brazilian-adults
#11
Ada Ávila Assunção, Mery Natali Silva Abreu
OBJECTIVE: To describe the prevalence of work-related musculoskeletal disorder (WMSD) and analyze the factors associated with this outcome in the Brazilian population. METHODS: In this cross-sectional, population-based study, we use data from the National Survey on Health (PNS) of 2013. The sample was composed of 60,202 Brazilians aged 18 years or older. The outcome variable was the occurrence of self-reported WMSD. Sociodemographic and occupational characteristics, personal resources, and health conditions were investigated as explanatory variables...
June 1, 2017: Revista de Saúde Pública
https://www.readbyqxmd.com/read/28584784/could-salivary-cyclosporine-dosage-replace-the-whole-blood-cyclosporine-measurements-in-renal-transplant-patients
#12
Samia Aboujaoude, Marwan Masri, Sylvana Rizk, Souleima Chamat, Jad Farha, Zeina Majzoub
BACKGROUND: Cyclosporin (CsA) has been extensively used as the immunosuppressant of choice in renal transplantation. Currently available approaches to assess CsA levels, both in serum and blood, fail to accurately reflect the concentration of the pharmacologically active drug fraction. Free CsA levels in biological fluids (blood or saliva) have been advocated to play an important role. Traditional salivary CsA monitoring tests are based on available archaic salivary techniques that are nonspecific and require large amounts of saliva...
May 2017: Journal of International Society of Preventive & Community Dentistry
https://www.readbyqxmd.com/read/28572165/long-term-impact-of-joint-bleeds-in-von-willebrand-disease-a-nested-case-control-study
#13
Karin P M van Galen, Piet de Kleijn, Wouter Foppen, Jeroen Eikenboom, Karina Meijer, Roger E G Schutgens, Kathelijn Fischer, Marjon H Cnossen, Joke de Meris, Karin Fijnvandraat, Johanna G van der Bom, Britta A P Laros-van Gorkom, Frank W G Leebeek, Evelien P Mauser-Bunschoten
Patients with severe von Willebrand Disease may develop arthropathy after joint bleeds. Limited information is available on its prevalence and severity. We aimed to assess the occurrence and severity of arthropathy in VWD and its impact on daily life. Von Willebrand Disease patients with and without verified joint bleeds were matched for age, gender and Factor VIII level or Von Willebrand Factor activity in a nested case-control study within the Willebrand in the Netherlands study. Assessments included the Hemophilia Joint Health Score (0-124), Pettersson score (0-13 per joint X-ray), Hemophilia Activity List score (0-100), joint pain (Visual Analog Scale 0-10) and Impact on Participation and Autonomy questionnaire (0-20)...
June 1, 2017: Haematologica
https://www.readbyqxmd.com/read/28559893/upregulation-of-early-and-downregulation-of-terminal-pathway-complement-genes-in-subcutaneous-adipose-tissue-and-adipocytes-in-acquired-obesity
#14
Sanna Kaye, A Inkeri Lokki, Anna Hanttu, Eija Nissilä, Sini Heinonen, Antti Hakkarainen, Jesper Lundbom, Nina Lundbom, Lilli Saarinen, Olli Tynninen, Maheswary Muniandy, Aila Rissanen, Jaakko Kaprio, Seppo Meri, Kirsi H Pietiläinen
Inflammation is an important mediator of obesity-related complications such as the metabolic syndrome but its causes and mechanisms are unknown. As the complement system is a key mediator of inflammation, we studied whether it is activated in acquired obesity in subcutaneous adipose tissue (AT) and isolated adipocytes. We used a special study design of genetically matched controls of lean and heavy groups, rare monozygotic twin pairs discordant for body mass index (BMI) [n = 26, within-pair difference (Δ) in body mass index, BMI >3 kg/m(2)] with as much as 18 kg mean Δweight...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28551026/dead-or-alive-the-elusive-quest-for-long-term-follow-up
#15
EDITORIAL
Carlos M Mery
No abstract text is available yet for this article.
April 28, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28549170/are-multidimensional-pain-inventory-coping-strategy-profiles-associated-with-long-term-spinal-cord-stimulation-effectiveness
#16
Mery Paroli, Olivia Bernini, Giuliano De Carolis, Lara Tollapi, Franca Bondi, Antonella Martini, Alessandro Dario, Adriana Paolicchi
Introduction.:  It is acknowledged that the way patients cope with pain may influence treatment outcome. In particular, psychological factors are deemed important when considering patients for suitability for spinal cord stimulation (SCS). Objective.:  The aim of the study is to observe how pre-implantation psychological characteristics impact the effectiveness of SCS for chronic pain. Methods.:  The analysis comprised data from 137 patients who underwent an SCS implant...
May 26, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28535555/paresthesia-independence-an-assessment-of-technical-factors-related-to-10-khz-paresthesia-free-spinal-cord-stimulation
#17
Giuliano De Carolis, Mery Paroli, Lara Tollapi, Matthew W Doust, Abram H Burgher, Cong Yu, Thomas Yang, Donna M Morgan, Kasra Amirdelfan, Leonardo Kapural, B Todd Sitzman, Richard Bundschu, Ricardo Vallejo, Ramsin M Benyamin, Thomas L Yearwood, Bradford E Gliner, Ashley A Powell, Kerry Bradley
BACKGROUND: Spinal cord stimulation (SCS) has been successfully used to treat chronic intractable pain for over 40 years. Successful clinical application of SCS is presumed to be generally dependent on maximizing paresthesia-pain overlap; critical to achieving this is positioning of the stimulation field at the physiologic midline. Recently, the necessity of paresthesia for achieving effective relief in SCS has been challenged by the introduction of 10 kHz paresthesia-free stimulation...
May 2017: Pain Physician
https://www.readbyqxmd.com/read/28526380/comparison-between-two-assessment-tools-for-fruit-and-vegetable-intake-relative-to-the-24-h-recall
#18
Mariana Souza Lopes, Luana Caroline Dos Santos, Aline Cristine Souza Lopes, Mery Natali Silva Abreu
OBJECTIVE: The aim of this study was to evaluate the validity of methods assessing fruit and vegetable (FV) intake among Brazilian users of the Primary Attention Health Care Program. METHODS: The present study included 299 participants (age ≥20 y) from a representative sample from a randomized controlled community trial performed as part of a health promotion program in a Brazilian metropolis. All participants completed three methods for the assessment of FV consumption: brief questionnaire of FV (QBrief-FV), food frequency questionnaire of FV, and a 24-h dietary recall...
June 2017: Nutrition
https://www.readbyqxmd.com/read/28509365/the-degree-of-satisfaction-of-in-hospital-medical-patients-with-nursing-care-and-predictors-of-dissatisfaction-findings-from-a-secondary-analysis
#19
Alvisa Palese, Silvia Gonella, Anna Fontanive, Annamaria Guarnier, Paolo Barelli, Paola Zambiasi, Elisabetta Allegrini, Letizia Bazoli, Paola Casson, Meri Marin, Marisa Padovan, Michele Picogna, Patrizia Taddia, Daniele Salmaso, Paolo Chiari, Tiziana Frison, Oliva Marognolli, Federica Canzan, Elisa Ambrosi, Luisa Saiani
BACKGROUND: Patient satisfaction with nursing care (NC) is an important predictor of overall satisfaction with the hospital experience. However, the concept of patient satisfaction has been criticised both at the theoretical and at the methodological levels, and more attention on patient dissatisfaction has been called for with the aim of identifying strategies to improve the quality of care. AIMS: To describe dissatisfaction with NC as perceived by acute medical patients and identify predictors...
May 16, 2017: Scandinavian Journal of Caring Sciences
https://www.readbyqxmd.com/read/28508034/laminar-localization-and-projection-specific-properties-of-presubicular-neurons-targeting-the-lateral-mammillary-nucleus-thalamus-or-medial-entorhinal-cortex
#20
Li-Wen Huang, Jean Simonnet, Mérie Nassar, Louis Richevaux, Roxanne Lofredi, Desdemona Fricker
The presubiculum (PrS) is part of an interconnected network of distributed brain regions where individual neurons signal the animals heading direction. PrS sends axons to medial entorhinal cortex (MEC), it is reciprocally connected with anterior thalamic nuclei (ATNs), and it sends feedback projections to the lateral mammillary nucleus (LMN), involved in generating the head direction signal. The intrinsic properties of projecting neurons will influence the pathway-specific transmission of activity. Here, we used projection-specific labeling of presubicular neurons to identify MEC-, LMN-, and ATN-projecting neurons in mice...
March 2017: ENeuro
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