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Transposition of the great vessels

Krzysztof W Michalak, Konrad Szymczyk, Jadwiga A Moll, Jacek J Moll
No abstract text is available yet for this article.
December 2016: Annals of Thoracic Surgery
Maulin U Vora, Megan J Christensen, Nicholas W Markin
No abstract text is available yet for this article.
July 12, 2016: Journal of Cardiothoracic and Vascular Anesthesia
Kelly Jarvis, Marleen Vonder, Alex J Barker, Susanne Schnell, Michael Rose, James Carr, Joshua D Robinson, Michael Markl, Cynthia K Rigsby
BACKGROUND: Peak velocity measurements are used to evaluate the significance of stenosis in patients with transposition of the great arteries after the arterial switch operation (TGA after ASO). 4D flow cardiovascular magnetic resonance (CMR) provides 3-directional velocity encoding and full volumetric coverage of the great arteries and may thus improve the hemodynamic evaluation in these patients. The aim of this study was to compare peak velocities measured by 4D flow CMR with 2D phase contrast (PC) CMR and the gold standard Doppler echocardiography (echo) in patients with TGA after ASO...
September 22, 2016: Journal of Cardiovascular Magnetic Resonance
Amudhan Jyothidasan, Susan Noe, Joe B Calkins
No abstract text is available yet for this article.
November 15, 2016: International Journal of Cardiology
Ralf Gold, Dusan Stefoski, Krzysztof Selmaj, Eva Havrdova, Christopher Hurst, Joan Holman, Belen Tornesi, Surekha Akella, Peter McCroskery
INTRODUCTION: Multiple sclerosis (MS) is more common in women and can occur during childbearing years; thus, information on outcomes following exposure to MS therapy during pregnancy is important. No formal studies of daclizumab have been conducted in pregnant women. Here, we report available nonclinical and clinical data on pregnancy outcomes from the daclizumab clinical study program. METHODS: Reproductive and developmental toxicity studies were conducted in cynomolgus monkeys...
December 2016: Neurology and Therapy
Josta de Jong, Ester Garne, Lolkje T W de Jong-van den Berg, Hao Wang
BACKGROUND: More information is needed about possible associations between the newer anti-epileptic drugs (AEDs) in the first trimester of pregnancy and specific congenital anomalies of the fetus. OBJECTIVES: We performed a literature review to find signals for potential associations between newer AEDs (lamotrigine, topiramate, levetiracetam, gabapentin, oxcarbazepine, eslicarbazepine, felbamate, lacosamide, pregabalin, retigabine, rufinamide, stiripentol, tiagabine, vigabatrin, and zonisamide) and specific congenital anomalies...
June 2016: Drugs—Real World Outcomes
Massimiliano Cantinotti, Raffaele Giordano, Alberto Clemente, Bruno Murzi, Nadia Assanta, Alessia Lunardini, Isabella Spadoni
We describe a case of transposition of the great arteries (TGA) with significant aortopulmonary collateral vessels causing management difficulties before and after an arterial switch operation. Preoperatively, the presence of collaterals exacerbated aortic diastolic runoff and led to myocardial ischemia. Postoperatively, despite uneventful extubation, the infant developed clinical heart failure characterized by pericardial and pleural effusions and feeding difficulties, which promptly resolved with percutaneous embolization of collaterals...
July 2016: Annals of Thoracic Surgery
Zhandong Zeng, Hongwei Zhang, Fengli Liu, Ning Zhang
Congenital heart defects (CHD) affect approximately 7% of infants, and account for 3% of all infant deaths. CHD is most often caused by the defects associated with ductus arteriosus, which is a vessel that usually closes shortly after birth. The types of CHD include tetralogy of fallot, hypoplastic left heart syndrome, pulmonary atresia, total anomalous pulmonary venous return, transposition of great arteries, tricuspid atresia and truncus arteriosus. There are some risk factors that can increase the chance of a fetus developing CHD such as prematurity, an existing CHD in a first-degree relative, genetic syndromes, infections in utero, maternal drug consumptions and disorders...
May 2016: Experimental and Therapeutic Medicine
Jeremy Zimmermann, J Ryan Altman, D Scott Gantt
Congenital cardiac abnormalities diagnosed at the time of acute coronary syndrome are rare. A 43-year-old man presented to the emergency department complaining of recurring, severe chest pain. Subsequent emergent coronary angiography demonstrated unusual coronary anatomy: 1) one small caliber bifurcating vessel originating from the right sinus of Valsalva; 2) one very large vessel arising from the posterior sinus; and 3) no coronary artery from the normal left sinus of Valsalva. The large vessel from the posterior sinus was totally occluded in its midportion and was treated with intravascular ultrasound-guided percutaneous coronary intervention...
April 2016: Proceedings of the Baylor University Medical Center
S T Koo, N L LeBlanc, K F Scollan, D D Sisson
A 2-year old intact male Collie dog presented to the cardiology service at Oregon State University for evaluation of cyanosis and suspected congenital cardiac disease. Echocardiography revealed a constellation of cardiac abnormalities including a single large vessel exiting the right ventricle with a diminutive left ventricular outflow tract, a ventricular septal defect, and marked concentric right ventricular hypertrophy with moderate right atrial dilation. Cardiac-gated computed tomography confirmed the previous anomalies in addition to supporting a diagnosis of complete transposition of the great arteries, double outlet right ventricle, and pulmonic hypoplasia with a single coronary ostium...
June 2016: Journal of Veterinary Cardiology: the Official Journal of the European Society of Veterinary Cardiology
Narcís Masoller, Magda Sanz-Cortés, Fàtima Crispi, Olga Gómez, Mar Bennasar, Gabriela Egaña-Ugrinovic, Núria Bargalló, Josep María Martínez, Eduard Gratacós
OBJECTIVES: We evaluated the hypothesis that in fetuses with congenital heart disease (CHD) there is a correlation between the expected pattern of in utero brain blood supply and the severity of neurodevelopmental impairment. METHODS: A total of 58 fetuses with CHD and 58 controls underwent a Doppler ultrasound and fetal MRI at 36-38 weeks. Fetuses with CHD were divided into two functional classes: class A with an expected severe reduction in oxygenated brain blood supply (left outflow tract obstruction and transposition of great vessels) and class B with theoretically near-normal or mildly impaired oxygenated brain blood supply (other CHD)...
2016: Fetal Diagnosis and Therapy
Rolf Alexander Jánosi, Riccardo Gorla, Konstantinos Tsagakis, Philipp Kahlert, Michael Horacek, Florian Bruckschen, Daniel-Sebastian Dohle, Heinz Jakob, Thomas Schlosser, Holger Eggebrecht, Eduardo Bossone, Raimund Erbel
PURPOSE: To analyze an 11-year single-center experience of treating complicated penetrating aortic ulcer (PAU) using thoracic endovascular aortic repair (TEVAR). METHODS: This study included 63 consecutive patients (mean age 69.1±11.5 years; 40 men) with complicated PAU (42 symptomatic, 22 with rupture) who underwent TEVAR between 2002 and 2013. The PAUs were located in the aortic arch (n=11), the descending thoracic aorta (n=43), and the thoracoabdominal aorta (n=9)...
February 2016: Journal of Endovascular Therapy
Ricardo A Weis, Patrick A Devaleria, Sarang Koushik, Harish Ramakrishna
INTRODUCTION: Advances in medical and surgical care have made it possible for an increasing number of patients with Congenital Heart disease (CHD) to live into adulthood. Transposition of the great vessels (TGV) is the most common cyanotic congenital cardiac disease where the right ventricle serves as systemic ventricle. It is not uncommon for these patients to have systemic ventricular failure requiring transplantation. STUDY DESIGN: Hemodynamic decompensation in these patients can be swift and difficult to manage...
October 2015: Annals of Cardiac Anaesthesia
Daniela Laux, Lucile Houyel, Fanny Bajolle, Francesca Raimondi, Younes Boudjemline, Damien Bonnet
BACKGROUND: Discordant atrioventricular with concordant ventriculo-arterial connections is a rare cardiac defect. When isolated, the haemodynamics resemble transposition of the great arteries. In complex heart defects such as heterotaxy, haemodynamics guide the surgical approach. OBJECTIVE: To report a series of eight patients with discordant atrioventricular and concordant ventriculo-arterial connections focussing on anatomical and diagnostic difficulties, surgical management, and follow-up...
January 2016: Cardiology in the Young
Francesco Nappi, Cristiano Spadaccio, Massimiliano Fraldi, Cristophe Acar
BACKGROUND: Supravalvular pulmonary stenosis (SPS) remains a worrisome complication in the long term of simple transposition of the great arteries. Issues of scar formation and inability to grow are considered at the base of this phenomenon. We pioneered the use of a tissue engineering approach to guide the maturation and the growth of pulmonary autograft in the Ross procedure with encouraging results. We therefore sought to investigate the use of a similar approach in the reconstruction of neopulmonary trunk (NPT) with the aim to recreate a vascular conduit that retains the structural architecture and the same biological potential of native pulmonary artery and prevents long-term SPS...
December 15, 2015: International Journal of Cardiology
Takeshi Tsuda, Abdul M Bhat, Bradley W Robinson, Jeanne M Baffa, Wolfgang Radtke
BACKGROUND: The incidence of late coronary artery abnormalities after arterial switch operation (ASO) for d-loop transposition of the great arteries may be underestimated. METHODS AND RESULTS: We retrospectively reviewed coronary artery morphology in 40 of 97 patients who survived the first year after ASO. Seven asymptomatic patients developed significant late coronary artery abnormalities. One patient died suddenly at home with severe left coronary artery (LCA) ostial stenosis at age 3...
2015: Circulation Journal: Official Journal of the Japanese Circulation Society
Justin S Brandt, Eileen Wang, Jack Rychik, Debbra Soffer, Margaret L McCann, Nadav Schwartz
OBJECTIVES: Prenatal diagnosis of congenital heart disease can improve neonatal outcomes. The purpose of this study was to evaluate the utility of an isolated 3-vessel view image in evaluating the ventricular outflow tracts. METHODS: Three-vessel view images were prospectively collected from consecutive patients referred to a regional fetal heart center for fetal echocardiography between gestational ages of 18 weeks and 23 weeks 6 days. Cardiac malformations were categorized as anomalies of the outflow tracts, the 4-chamber view, or combined lesions...
August 2015: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
Takeshi Konuma, Hideto Shimpo
Transposition of the great artery is one of common congenital cardiac disease resulting cyanosis. Death occurs easily in untreated patients with transposition and intact ventricular septal defect (VSD) in infancy at a few days of age when posterior descending coronary artery (PDA) closed. Since there are 2 parallel circulations, flow from pulmonary to systemic circulation is necessary for systemic oxygenation, and Balloon atrial septostomy or prostaglandin infusion should be performed especially if patient do not have VSD...
July 2015: Kyobu Geka. the Japanese Journal of Thoracic Surgery
James S Tweddell
No abstract text is available yet for this article.
August 25, 2015: Circulation
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