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https://www.readbyqxmd.com/read/28730843/clinical-value-of-st-segment-change-after-return-of-spontaneous-cardiac-arrest-and-emergent-coronary-angiography-in-patients-with-out-of-hospital-cardiac-arrest-diagnostic-and-therapeutic-importance-of-vasospastic-angina
#1
Kazuya Tateishi, Daisuke Abe, Tooru Iwama, Yuichi Hamabe, Kazutaka Aonuma, Akira Sato
BACKGROUND: We investigated the association between initial ST-segment change after return of spontaneous circulation (ROSC) and the incidence of acute coronary lesions in patients with out-of-hospital cardiac arrest (OHCA), and clinical outcomes of patients with OHCA caused by vasospastic angina pectoris (VSA). METHODS: Among 2779 OHCA patients in our institution, all patients with ROSC underwent emergent coronary angiography (CAG) except for those with an obvious extra-cardiac cause of OHCA...
July 1, 2017: European Heart Journal. Acute Cardiovascular Care
https://www.readbyqxmd.com/read/28715070/evaluation-of-the-relationship-between-renal-resistive-index-and-extensivity-and-complexity-of-coronary-artery-disease-in-patients-with-acute-coronary-syndrome
#2
Alaa Quisi, Ibrahim Halil Kurt, Durmuş Yıldıray Şahin, Onur Kaypaklı, Gökhan Söker, Ömer Kaya, Samir Allahverdiyev, Ömer Genç, Gökhan Alıcı, Mevlüt Koç
BACKGROUND: Despite the advances in cardiovascular medicine, acute coronary syndrome (ACS) is still a major cause of morbidity and mortality worldwide. Synergy between PCI ™ with TAXUS and Cardiac Surgery (SYNTAX) score is used to determine the extensivity and complexity of coronary artery disease (CAD). Renal resistive index (RRI), a renal Doppler ultrasound parameter, is used to detect renal hemodynamics. Although some risk factors for CAD, including hypertension and diabetes mellitus were demonstrated to have an association with RRI, direct relationship between the presence...
July 17, 2017: Kardiologia Polska
https://www.readbyqxmd.com/read/28714978/%C3%AE-ketoglutarate-orchestrates-macrophage-activation-through-metabolic-and-epigenetic-reprogramming
#3
Pu-Ste Liu, Haiping Wang, Xiaoyun Li, Tung Chao, Tony Teav, Stefan Christen, Giusy Di Conza, Wan-Chen Cheng, Chih-Hung Chou, Magdalena Vavakova, Charlotte Muret, Koen Debackere, Massimiliano Mazzone, Hsien-Da Huang, Sarah-Maria Fendt, Julijana Ivanisevic, Ping-Chih Ho
Glutamine metabolism provides synergistic support for macrophage activation and elicitation of desirable immune responses; however, the underlying mechanisms regulated by glutamine metabolism to orchestrate macrophage activation remain unclear. Here we show that the production of α-ketoglutarate (αKG) via glutaminolysis is important for alternative (M2) activation of macrophages, including engagement of fatty acid oxidation (FAO) and Jmjd3-dependent epigenetic reprogramming of M2 genes. This M2-promoting mechanism is further modulated by a high αKG/succinate ratio, whereas a low ratio strengthens the proinflammatory phenotype in classically activated (M1) macrophages...
July 17, 2017: Nature Immunology
https://www.readbyqxmd.com/read/28708502/temporal-effect-of-maternal-heat-stress-during-gestation-on-the-fertility-and-anti-m%C3%A3-llerian-hormone-concentration-of-offspring-in-bovine
#4
V Akbarinejad, F Gharagozlou, M Vojgani
Ovarian reserve has been suggested as an important contributing factor of reproductive success in bovine. Size of ovarian reserve is determined during fetal period and it could be altered by environmental factors, with which the dam is exposed. Maternal heat stress could impair placental function and fetal development; however, there is limited information on the impact of prenatal heat stress on fertility and ovarian reserve in the offspring. Therefore, a retrospective study was conducted, in which fertility parameters and AMH concentration, as a reliable marker of ovarian reserve in bovine, were studied in the offspring of dams that had been exposed to heat stress during the first (FTE), second (STE) or third (TTE) trimester of gestation and the offspring of dams unexposed to heat stress (US)...
May 28, 2017: Theriogenology
https://www.readbyqxmd.com/read/28708037/greater-sensitivity-of-oral-fibroblasts-to-smoked-vs-smokeless-tobacco
#5
Thomas E Lallier, John T Moylan, Erin Maturin
OBJECTIVE: Smokers have an increased incidence and severity of periodontal disease. While cigarette smoke contains over 4,000 chemical components that could affect periodontal tissues, less is understood about the effect of smokeless tobacco. Therefore, this study compared the effects of cigarette smoke extract (CSE) to smokeless tobacco extract (STE) on cell survival and motility of periodontal ligament (PDL) and gingival fibroblasts in vitro. METHODS: PDL and gingival fibroblasts were exposed to varying concentrations of CSE, STE or nicotine alone...
July 14, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28686116/clinical-radiological-and-histological-features-and-treatment-outcomes-of-supratentorial-extraventricular-ependymoma-14-cases-from-a-single-center
#6
Shoujia Sun, Junwen Wang, Mingxin Zhu, Rajluxmee Beejadhursing, Pan Gao, Xiaojing Zhang, Liwu Jiao, Wei Jiang, Changshu Ke, Kai Shu
OBJECTIVE Reports on supratentorial extraventricular ependymoma (STE) are relatively rare. The object of this study was to analyze the clinical, radiological, and histological features and treatment outcomes of 14 patients with STE. METHODS Overall, 227 patients with ependymoma underwent surgical treatment in the authors' department between January 2010 and June 2015; 14 of these patients had STE. Data on clinical presentation, radiological studies, histopathological findings, surgical strategies, and treatment outcomes in these 14 cases were retrospectively analyzed...
July 7, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28685315/clinical-feasibility-and-validation-of-3d-principal-strain-analysis-from-cine-mri-comparison-to-2d-strain-by-mri-and-3d-speckle-tracking-echocardiography
#7
Alessandro Satriano, Bobak Heydari, Mariam Narous, Derek V Exner, Yoko Mikami, Monica M Attwood, John V Tyberg, Carmen P Lydell, Andrew G Howarth, Nowell M Fine, James A White
Two-dimensional (2D) strain analysis is constrained by geometry-dependent reference directions of deformation (i.e. radial, circumferential, and longitudinal) following the assumption of cylindrical chamber architecture. Three-dimensional (3D) principal strain analysis may overcome such limitations by referencing intrinsic (i.e. principal) directions of deformation. This study aimed to demonstrate clinical feasibility of 3D principal strain analysis from routine 2D cine MRI with validation to strain from 2D tagged cine analysis and 3D speckle tracking echocardiography...
July 6, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28678927/global-longitudinal-strain-or-left-ventricular-twist-and-torsion-which-correlates-best-with-ejection-fraction
#8
Marcio Silva Miguel Lima, Hector R Villarraga, Maria Cristina Donadio Abduch, Marta Fernandes Lima, Cecilia Beatriz Bittencourt Viana Cruz, João Cesar Nunes Sbano, Mariana Callil Voos, Wilson Mathias, Jeane Mike Tsutsui
Background: Estimative of left ventricular ejection fraction (LVEF) is a major indication for echocardiography. Speckle tracking echocardiography (STE) allows analysis of LV contraction mechanics which includes global longitudinal strain (GLS) and twist/torsion, both the most widely used. Direct comparison of correlations between these novel parameters and LVEF has never been done before. Objective: This study aims to check which one has the highest correlation with LVEF...
June 29, 2017: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/28673476/prediction-for-improvement-and-remodeling-in-first-onset-myocardial-infarction-by-speckle-tracking-echocardiography-is-global-or-regional-selection-better
#9
Bo Hu, Qing Zhou, Jinling Chen, Tuantuan Tan, Xue Yao, Hongning Song, Ruiqiang Guo
Cardiac function improvement and chamber remodeling after the onset of acute myocardial infarction (AMI) is crucial as it is closely related to the outcomes of patients. We sought to investigate the predictive value of left ventricular (LV) global and region of interest (ROI) assessment for prognosis of AMI patients by speckle tracking echocardiography (STE). We prospectively enrolled 81 first-onset AMI patients for baseline and 6-mo follow-up analysis. The echocardiography-derived parameters were compared in receiver operator characteristics (ROC) analysis for prediction of LV remodeling (LVR) (a minimum 20% increase of LV end-diastolic volume) and cardiac function improvement (a minimum 5% increase of LV ejection fraction)...
June 30, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28670832/association-between-left-ventricular-perfusion-defects-and-myocardial-deformation-indexes-in-heart-transplantation-recipients
#10
Antonello D'Andrea, Maria Luisa De Rimini, Raffaella America, Chiara Cirillo, Lucia Riegler, Giuseppe Limongelli, Michele D'Alto, Gemma Salerno, Ciro Maiello, Pietro Muto, Maria Giovanna Russo, Raffaele Calabrò, Eduardo Bossone, Giuseppe Pacileo
The aim of the study was to analyze possible correlations between strain echocardiography (STE) and PET myocardial perfusion in a population of heart transplantation (HTx) recipients showing preserved left ventricular (LV) ejection fraction. By STE, LV global longitudinal strain (LV GLS) was lower in HTx. PET showed no transient or chronic ischemia in 83 of 115 HTx (73%). Fixed perfusion defects were observed in 17% of HTx and reversible ischemia in 10%. Significant coronary stenosis was observed only in 10 cases...
July 3, 2017: Echocardiography
https://www.readbyqxmd.com/read/28668142/left-atrial-phasic-function-and-its-association-with-atrial-fibrillation-in-patients-after-transcatheter-aortic-valve-implantation
#11
Frédéric Poulin, Paaladinesh Thavendiranathan, Shemy Carasso, Harry Rakowski, Eric M Horlick, Mark D Osten, Robert J Cusimano, Anna Woo
BACKGROUND: Left atrial (LA) size is a marker of prognosis in severe aortic stenosis (AS). The aims of this retrospective study were to assess the impact of transcatheter aortic valve implantation (TAVI) on the recovery of LA phasic function and to assess the relationship between LA function and new-onset atrial fibrillation (NAF) after TAVI. METHODS: In this retrospective cohort study, LA function was measured using biplane volumes and 2-dimensional (2D) speckle tracking echocardiography (STE) in 52 patients (median age, 81 years) with severe AS before TAVI and at midterm follow-up...
July 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28664601/left-atrial-strain-predicts-hemodynamic-parameters-in-cardiovascular-patients
#12
Bernd Hewing, Lena Theres, Sebastian Spethmann, Karl Stangl, Henryk Dreger, Fabian Knebel
BACKGROUND: We aimed to evaluate the predictive value of left atrial (LA) reservoir, conduit, and contractile function parameters as assessed by speckle tracking echocardiography (STE) for invasively measured hemodynamic parameters in a patient cohort with myocardial and valvular diseases. METHODS: Sixty-nine patients undergoing invasive hemodynamic assessment were enrolled into the study. Invasive hemodynamic parameters were obtained by left and right heart catheterization...
June 29, 2017: Echocardiography
https://www.readbyqxmd.com/read/28663062/community-pharmacist-training-and-communication-network-and-drug-related-problems-in-patients-with-ckd-a-multicenter-cluster-randomized-controlled-trial
#13
Lyne Lalonde, Patricia Quintana-Bárcena, Anne Lord, Robert Bell, Valérie Clément, Anne-Marie Daigneault, Marie-Ève Legris, Sara Letendre, Marie Mouchbahani, Ghaya Jouini, Joëlle Azar, Élisabeth Martin, Djamal Berbiche, Stephanie Beaulieu, Sébastien Beaunoyer, Émilie Bertin, Marianne Bouvrette, Noémie Charbonneau-Séguin, Jean-François Desrochers, Katherine Desforges, Ariane Dumoulin-Charette, Sébastien Dupuis, Maryame El Bouchikhi, Roxanne Forget, Marianne Guay, Jean-Phillippe Lemieux, Claudia Morin-Bélanger, Isabelle Noël, Stephanie Ricard, Patricia Sauvé, François Ste-Marie Paradis
BACKGROUND: Appropriate training for community pharmacists may improve the quality of medication use. Few studies have reported the impact of such programs on medication management for patients with chronic kidney disease (CKD). STUDY DESIGN: Multicenter, cluster-randomized, controlled trial. SETTING & PARTICIPANTS: Patients with CKD stage 3a, 3b, or 4 from 6 CKD clinics (Quebec, Canada) and their community pharmacies. INTERVENTION: Each cluster (a pharmacy and its patients) was randomly assigned to either ProFiL, a training-and-communication network program, or the control group...
June 26, 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/28660792/left-ventricular-torsion-in-patients-with-obstructive-sleep-apnoea-before-and-after-continuous-positive-airway-pressure-therapy-assessment-by-two-dimensional-speckle-tracking-echocardiography
#14
Mustafa Gökhan Vural, Süha Çetin, Nurgül Keser, Hikmet Firat, Ramazan Akdemir, Huseyin Gunduz
BACKGROUND: The purpose of the present study was to evaluate how obstructive sleep apnoea (OSA) influences left ventricular (LV) torsion and whether nasal continuous positive airway pressure (CPAP) therapy has any impact on LV torsion in OSA patients with established cardiovascular risk factors. METHODS: LV torsion was assessed by two-dimensional speckle tracking echocardiography (STE) in 162 participants without overt cardiovascular disease. The participants were categorized according to the apnoea-hypopnea index (AHI) as controls and mild, moderate and severe OSA patients...
June 29, 2017: Acta Cardiologica
https://www.readbyqxmd.com/read/28658071/a-review-of-field-based-assessments-of-neuromuscular-control-and-their-utility-in-male-youth-soccer-players
#15
Paul J Read, Jon L Oliver, Mark B A De Ste Croix, Gregory D Myer, Rhodri S Lloyd
Lower extremity injuries in male youth soccer are common and equate to a substantial time-loss from training and competitions during the course of a season. Extended periods of absence will impact player involvement in skill and physical development activities, as well as participation in competitive match play. Neuromuscular risk factors for lower extremity injury in male youth soccer players can be categorized into quadriceps dominance; leg dominance; ligament dominance; trunk dominance and reduced dynamic stability...
June 22, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28652808/persistent-cauda-equina-syndrome-after-caudal-epidural-injection-under-severe-spinal-stenosis-a-case-report
#16
Young Tak Seo, Hyun Ho Kong, Goo Joo Lee, Heui Je Bang
Caudal epidural injection (CEI) is one of the most common treatments for low-back pain with sciatica. CEI rarely leads to neurologic complications. We report a case of persistent cauda equina syndrome after CEI. A 44-year-old male patient with severe L4 and L5 spinal ste-nosis underwent CEI for low-back pain and sciatica. The CEI solution consisted of bupivacaine, hyaluronidase, triamcinolone acetonide, and normal saline. He experienced motor weakness and sensory loss in both lower extremities and neurogenic bladder for more than 1 year after the procedure...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28648418/longitudinal-ventricular-systolic-dysfunction-in-patients-with-very-severe-obstructive-sleep-apnea-a-case-control-study-using-speckle-tracking-imaging
#17
Mithun Jacob Varghese, Gautam Sharma, Garima Shukla, Sandeep Seth, Sundeep Mishra, Anupama Gupta, Vinay Kumar Bahl
OBJECTIVE: Obstructive sleep apnea (OSA) is a prevalent condition that is increasingly recognized to be associated with cardiovascular disease. We aimed to investigate the subclinical systolic ventricular dysfunction of patients with OSA using novel speckle tracking echocardiographic (STE) techniques. METHODS: This study included 31 patients of polysomnography proven very severe OSA [Apnea Hypopnea Index(AHI) >40] and an equal number of matched population with no OSA as controls...
May 2017: Indian Heart Journal
https://www.readbyqxmd.com/read/28639243/right-atrial-myocardial-deformation-by-two-dimensional-speckle-tracking-echocardiography-predicts-recurrence-in-paroxysmal-atrial-fibrillation
#18
Malini Govindan, Anatoli Kiotsekoglou, Samir K Saha, A John Camm
BACKGROUND: Atrial fibrillation (AF) is a bi-atrial disease yet little attention has been given to right heart function in AF. We propose that the assessment of right atrial (RA) and right ventricular function (RV) using two-dimensional speckle tracking echocardiography (2D-STE) could be valuable in predicting AF recurrence in patients with paroxysmal AF (PAF). METHODS: Thirty patients with PAF were prospectively recruited from a dedicated AF clinic. Right atrial size, volume, and area and RV dimensions were analyzed along with RA and RV strain derived from 2D-STE at baseline and at 3 and 12 months...
June 21, 2017: Journal of Echocardiography
https://www.readbyqxmd.com/read/28638961/evaluation-of-systolic-and-diastolic-properties-of-hypertensive-heart-failure-using-speckle-tracking-echocardiography-with-high-volume-rates
#19
Shingo Minatoguchi, Masanori Kawasaki, Ryuhei Tanaka, Takashi Yoshizane, Koji Ono, Maki Saeki, Maki Nagaya, Hidemaro Sato, Kazuhiko Nishigaki, Toshiyuki Noda, Michael R Zile, Shinya Minatoguchi
Left ventricular (LV) properties in hypertension (HTN) could be deteriorated by pressure overload, especially in endocardium, resulting in hypertensive heart failure (HHF). We sought to noninvasively examine LV systolic and diastolic functions at three myocardial layers in HTN and elucidate features of HHF by speckle-tracking echocardiography (STE) with high volume rates. We examined normotensive controls (n = 54), HTN patients without LV hypertrophy (LVH) (n = 50), and HTN patients with LVH (n = 40) and HHF patients (n = 45)...
June 21, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/28629855/con4ei-development-of-serious-eye-damage-and-eye-irritation-testing-strategies-with-respect-to-the-requirements-of-the-un-ghs-eu-clp-hazard-categories
#20
Sandra Verstraelen, An R Van Rompay
The main objective of the CON4EI (CONsortium for in vitro Eye Irritation testing strategy) project (2015-2016) was to develop tiered, non-animal testing strategies for serious eye damage and eye irritation assessment in relation to the most important drivers of classification. The serious eye damage and eye irritation potential of a set of 80 chemicals was identified based on existing in vivo Draize eye test data and testing was conducted using the following eight alternative test methods: BCOP (Bovine Corneal Opacity and Permeability)+histopathology, BCOP-LLBO (BCOP Laser Light-Based Opacitometer), ICE (Isolated Chicken Eye)+histopathology, STE (Short Term Exposure), EpiOcular™ EIT (EpiOcular Eye Irritation Test), EpiOcular™ ET-50 (EpiOcular™ Time-to-toxicity), SkinEthic™ HCE EIT (SkinEthic™ Human Corneal Epithelial Eye Irritation Test), and SMI (Slug Mucosal Irritation)...
June 16, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
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