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https://www.readbyqxmd.com/read/27910996/speckle-tracking-echocardiography-predicts-early-subclinical-anthracycline-cardiotoxicity-in-patients-with-breast-cancer
#1
Qi Tang, Yan Jiang, Yali Xu, Hongmei Xia
PURPOSE: This study aimed to assess the early changes of left ventricular (LV) and right ventricular (RV) mechanics associated with anthracycline treatment for breast cancer and to determine whether two-dimensional speckle tracking echocardiography (2D-STE) analysis could predict chemotherapy-induced cardiotoxicity. BACKGROUND: Anthracycline generates progressive LV dysfunction associated with a poor prognosis. Early detection of minor change of myocardial mechanics is thus important...
December 2, 2016: Journal of Clinical Ultrasound: JCU
https://www.readbyqxmd.com/read/27904028/prognostic-value-of-eosinophil-to-leukocyte-ratio-in-patients-with-st-elevation-myocardial-infarction-undergoing-primary-percutaneous-coronary-intervention
#2
Takao Konishi, Naohiro Funayama, Tadashi Yamamoto, Toru Morita, Daisuke Hotta, Hiroshi Nishihara, Shinya Tanaka
AIM: Leukocyte profile has been related to clinical outcome in patients with ST-segment elevation (STE) myocardial infarction (MI). However, whether eosinophil to leukocyte ratio (ELR) predicts clinical outcome in patients who have undergone primary percutaneous coronary intervention (PCI) remains unclear. Therefore, we examined the prognostic value of ELR in this patient population. METHODS: We retrospectively analyzed the data of 331 consecutive patients who underwent primary PCI for STEMI between January 2009 and March 2015...
December 1, 2016: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/27903438/neurite-density-imaging-versus-imaging-of-microscopic-anisotropy-in-diffusion-mri-a-model-comparison-using-spherical-tensor-encoding
#3
Björn Lampinen, Filip Szczepankiewicz, Johan Mårtensson, Danielle van Westen, Pia C Sundgren, Markus Nilsson
In diffusion MRI (dMRI), microscopic diffusion anisotropy can be obscured by orientation dispersion. Separation of these properties is of high importance, since it could allow dMRI to non-invasively probe elongated structures such as neurites (axons and dendrites). However, conventional dMRI, based on single diffusion encoding (SDE), entangles microscopic anisotropy and orientation dispersion with intra-voxel variance in isotropic diffusivity. SDE-based methods for estimating microscopic anisotropy, such as the neurite orientation dispersion and density imaging (NODDI) method, must thus rely on model assumptions to disentangle these features...
November 26, 2016: NeuroImage
https://www.readbyqxmd.com/read/27893475/leg-stiffness-in-female-soccer-players-inter-session-reliability-and-the-fatiguing-effects-of-soccer-specific-exercise
#4
Mark De Ste Croix, Jonathan Hughes, Rhodri S Lloyd, Jon L Oliver, Paul Read
Low levels of leg stiffness and reduced leg stiffness when fatigue is present compromise physical performance and increase injury risk. The purpose of this study was to (a) determine the reliability of leg stiffness measures obtained from contact mat data and (b) explore age-related differences in leg stiffness following exposure to a soccer-specific fatigue protocol in young female soccer players. 37 uninjured female youth soccer players divided into 3 sub-groups based on chronological age (U13, U15 and U17 year olds) volunteered to participate in the study...
November 16, 2016: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/27885496/descending-aortic-mechanics-and-atrial-fibrillation-a-two-dimensional-speckle-tracking-transesophageal-echocardiography-study
#5
Rogério Teixeira, Ricardo Monteiro, Paulo Dinis, Maria José Santos, Ana Botelho, Nuno Quintal, Nuno Cardim, Lino Gonçalves
Vascular mechanics assessed with two-dimensional speckle tracking echocardiography (2D-STE) could be used as a new imaging surrogate of vascular stiffening. The CHA2DS2-VASc score is considered accurate as an estimate of stroke risk in non-valvular AF, although many potential stroke risk factors have not been included in this scoring method. The purpose of this research is to study the feasibility of evaluating vascular mechanics at the descending aorta in non-valvular AF patients using transesophageal 2D-STE and to analyze the association between descending aortic mechanics and stroke...
November 24, 2016: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/27878628/global-deformation-parameters-response-to-exercise-in-adolescents-with-repaired-tetralogy-of-fallot
#6
Timur Mese, Baris Guven, Murat Muhtar Yilmazer, Mustafa Demirol, Şenay Çoban, Cem Karadeniz
Exercise stress echocardiography is rarely used in the follow-up of children with congenital heart disease following surgical repair. There are no data on global longitudinal strain (GLS) and global circumferential strain (GCS) during exercise in adolescents with repaired tetralogy of Fallot (TOF). The purpose of this prospective study was to investigate GLS and GCS using speckle tracking two-dimensional echocardiography (2D-STE) at rest and during exercise in adolescents with repaired TOF. Twenty patients with repaired TOF and 20 controls were included...
November 23, 2016: Pediatric Cardiology
https://www.readbyqxmd.com/read/27874244/coarctation-repair-normalizes-left-ventricular-function-and-aorto-septal-angle-in-neonates
#7
Haki Jashari, Katarina Lannering, Mats Mellander, Pranvera Ibrahimi, Annika Rydberg, Michael Y Henein
BACKGROUND AND AIMS: Patients with coarctation of the aorta (CoA) have increased left ventricular (LV) afterload that has been shown to impact the LV and ascending aortic function. We aimed to examine the effect of coarctation on LV function and aorto-septal angle (AoSA) before and after surgical repair. METHODS: We retrospectively studied 21 patients with surgically repaired CoA at a median age of 9 (2-53) days at three time points: (1) just before intervention, (2) at short-term follow-up, and (3) at medium-term follow-up after intervention...
November 22, 2016: Congenital Heart Disease
https://www.readbyqxmd.com/read/27873135/left-atrium-the-last-bulwark-before-overt-heart-failure
#8
Matteo Cameli, Giulia Elena Mandoli, Sergio Mondillo
Heart failure (HF) with preserved ejection fraction (HFpEF) has emerged as an important public health issue in recent years. It represents the most common type of HF in ambulatory setting, and it has been recognized as a different entity from the reduced ejection fraction (EF) form. In HFpEF, continuous growing attention has been focused on the role of the left atrium (LA) in preserving good ventricular function and asymptomatic condition of the patient since the very first stages of diastolic dysfunction (DD)...
November 22, 2016: Heart Failure Reviews
https://www.readbyqxmd.com/read/27873127/radiotherapy-induced-global-and-regional-differences-in-early-stage-left-sided-versus-right-sided-breast-cancer-patients-speckle-tracking-echocardiography-study
#9
Suvi Sirkku Tuohinen, Tanja Skyttä, Tuija Poutanen, Heini Huhtala, Vesa Virtanen, Pirkko-Liisa Kellokumpu-Lehtinen, Pekka Raatikainen
Radiotherapy (RT) to the thoracic region increases late cardiovascular morbidity and mortality. The impact of breast cancer laterality on cardiac function is largely unknown. The aim of this prospective study was to compare RT-induced changes in left-sided and right-sided breast cancer patients using speckle tracking echocardiography (STE). Sixty eligible patients with left-sided breast cancer and 20 with right-sided breast cancer without chemotherapy were evaluated prospectively before and early after RT. A comprehensive echocardiographic examination included three dimensional measurements and STE of the left ventricle (LV)...
November 21, 2016: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/27851876/modeling-diffusion-of-intracellular-metabolites-in-the-mouse-brain-up-to-very-high-diffusion-weighting-diffusion-in-long-fibers-almost-accounts-for-non-monoexponential-attenuation
#10
Marco Palombo, Clemence Ligneul, Julien Valette
PURPOSE: To investigate how intracellular metabolites diffusion measured in vivo up to very high q/b in the mouse brain can be explained in terms of simple geometries. METHODS: 10 mice were scanned using our new STE-LASER sequence, at 11.7 Tesla (T), up to qmax = 1 μm(-1) at diffusion time td = 63.2 ms, corresponding to bmax = 60 ms/µm². We model cell fibers as randomly oriented cylinders, with radius a and intracellular diffusivity Dintracyl, and fit experimental data as a function of q to estimate Dintracyl and a...
November 7, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/27832782/quantitative-evaluation-of-longitudinal-strain-in-layer-specific-myocardium-during-normal-pregnancy-in-china
#11
Juan Cong, Zhibin Wang, Hong Jin, Wugang Wang, Kun Gong, Yuanyuan Meng, Yong Lee
BACKGROUND: The myocardial wall of the left ventricle is a complex, multilayered structure and is not homogenous. The aim of this study was to determine longitudinal strain (LS) in the three myocardial layers in normal pregnant women according to gestation proceedings. METHODS: The advanced two-dimensional speckle tracking echocardiography (2D STE) was performed on 62 women during each pregnancy trimester and 6 to 9 weeks after delivery, while 30 age-matched, healthy, nonpregnant women served as controls...
November 10, 2016: Cardiovascular Ultrasound
https://www.readbyqxmd.com/read/27829525/characteristics-of-early-repolarization-parameters-and-prognostic-implications-in-the-general-ambulatory-korean-population
#12
Min Soo Cho, Chang Hee Kwon, Gi-Byoung Nam, Woo Seok Lee, Ki Won Hwang, Yong Giun Kim, Hyung Oh Choi, Sung-Hwan Kim, Jeongsoon Kim, Hyo-Jung Nam, Sun-Yang Min, Minsu Kim, Ji Hyun Lee, You Mi Hwang, Uk Jo, Jun Kim, Kee-Joon Choi, You-Ho Kim
BACKGROUND: We tested a hypothesis that the 2 fundamental components of early repolarization (ER), J wave and ST elevation (STE) might have different prevalence and prognostic implications. METHODS: The study population comprised 26,345 general ambulatory Korean subjects (mean 48.0±10.2years old, 53.2% male) who underwent medical checkups from January 2002 to December 2002. ER was found in 2950 subjects (11.2%), who were divided into 3 groups (J [J wave only, n=1874, 7...
November 1, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27829458/retrospective-epidemiological-study-of-canine-epilepsy-in-japan-using-the-international-veterinary-epilepsy-task-force-classification-2015-2003-2013-etiological-distribution-risk-factors-survival-time-and-lifespan
#13
Yuji Hamamoto, Daisuke Hasegawa, Shunta Mizoguchi, Yoshihiko Yu, Masae Wada, Takayuki Kuwabara, Aki Fujiwara-Igarashi, Michio Fujita
BACKGROUND: Epilepsy is the most common neurological disease in veterinary practice. However, contrary to human medicine, epilepsy classification in veterinary medicine had not been clearly defined until recently. A number of reports on canine epilepsy have been published, reflecting in part updated proposals from the human epilepsy organization, the International League Against Epilepsy. In 2015, the International Veterinary Epilepsy Task Force (IVETF) published a consensus report on the classification and definition of canine epilepsy...
November 9, 2016: BMC Veterinary Research
https://www.readbyqxmd.com/read/27816536/biotransformation-of-the-fungal-neurotoxin-thomitrem-a-by-primary-rat-hepatocytes
#14
Christiane K Fæste, Angel Moldes-Anaya
The tremorgenic mycotoxin Thomitrem A is a secondary metabolite produced mainly by the fungus Penicillium crustosum that is frequently found on spoiled stored food and feed. Typical signs of intoxication observed in dogs after the consumption of food waste are emesis, tremors, seizures progressing to ataxia and lack of coordinated movements. How uptake of Thomitrem A relates to exposure is unknown so far since data on biotransformation and toxicokinetics are missing. In this study the toxin was therefore metabolised in an exploratory in vitro experiment by rat hepatocytes, and substrate depletion as well as the formation of hepatic metabolites were investigated...
December 15, 2016: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/27805591/transthoracic-speckle-tracking-echocardiography-for-the-quantitative-assessment-of-left-ventricular-myocardial-deformation
#15
Kai O Hensel, Lucia Wilke, Andreas Heusch
The value of conventional echocardiography is limited by differences in inter-individual image interpretation and therefore largely dependent on the examiners' expertise. Speckle tracking Echocardiography (STE) is a promising but technically challenging method that can be used to quantitatively assess regional and global systolic and diastolic myocardial performance. Myocardial strain and strain rate can be measured in all three dimensions - radial, circumferential, longitudinal - of myocardial deformation...
October 20, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27805405/tributyl-phosphate-aggregation-in-the-presence-of-metals-an-assessment-using-diffusion-nmr-spectroscopy
#16
Anna G Baldwin, Yuan Yang, Nicholas J Bridges, Jenifer Claire Braley
Diffusion nuclear magnetic resonance (NMR) spectroscopy was used to find the inter-aggregate interactions and sizes of tributyl phosphate (TBP) aggregates containing varying concentrations of uranium or zirconium and HNO3 in an n-dodecane diluent. The average diffusion coefficients of TBP species were measured using a pulsed-field gradient stimulated echo experiment with a longitudinal eddy-current delay (STE-LED). Inter-aggregate interactions were determined by measuring the diffusion coefficient of TBP in a sample after a series of dilutions with n-dodecane...
November 2, 2016: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/27803347/dr-fitzcharles-et-al-reply
#17
Mary-Ann Fitzcharles, Peter A Ste-Marie, Emmanouil Rampakakis, John S Sampalis, Yoram Shir
No abstract text is available yet for this article.
November 2016: Journal of Rheumatology
https://www.readbyqxmd.com/read/27798456/future-considerations-based-on-the-information-from-barrter-s-and-gitelman-s-syndromes
#18
Hadas Alfandary, Daniel Landau
PURPOSE OF REVIEW: Bartter and Gitelman syndromes are typical normotensive salt losing hypokalaemic tubulopathies. Their pathogenesis was gradually deciphered in the past 5 decades, first by typical salt balance studies and histopathology, followed by genetic characterization and discovery of the affected different ion channels. Although the different genotypic subtypes were originally thought to show a similar phenotype, important clinical and biochemical differences can now be found...
January 2017: Current Opinion in Nephrology and Hypertension
https://www.readbyqxmd.com/read/27793208/myocardial-function-at-the-early-phase-of-traumatic-brain-injury-a-prospective-controlled-study
#19
Adrien Cuisinier, Claire Maufrais, Jean-François Payen, Stephane Nottin, Guillaume Walther, Pierre Bouzat
BACKGROUND: The concept of brain-heart interaction has been described in several brain injuries. Traumatic brain injury (TBI) may also lead to cardiac dysfunction but evidences are mainly based upon experimental and clinical retrospective studies. METHODS: We conducted a prospective case-control study in a level I trauma center. Twenty consecutive adult patients with severe TBI were matched according to age and gender with 20 control patients. The control group included adult patients undergoing a general anesthesia for a peripheral trauma surgery...
October 28, 2016: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://www.readbyqxmd.com/read/27792652/incremental-value-of-speckle-tracking-echocardiography-to-predict-cardiac-resynchronization-therapy-crt-responders
#20
Yoshihiro Seo, Tomoko Ishizu, Tomoko Machino-Ohtsuka, Masayoshi Yamamoto, Takeshi Machino, Kenji Kuroki, Hiro Yamasaki, Yukio Sekiguchi, Akihiko Nogami, Kazutaka Aonuma
BACKGROUND: Speckle tracking echocardiography (STE) is reported as a useful method to predict cardiac resynchronization therapy (CRT) responders. This study aimed to identify the incremental value of a STE parameter to predict CRT responders. METHODS AND RESULTS: We enrolled 171 patients from the Speckle Tracking imaging for the Assessment of cardiac Resynchronization Therapy (START) study. CRT responders were defined as patients with ≥15% reduction of left ventricular (LV) end-systolic volume at 6 months post-CRT...
October 19, 2016: Journal of the American Heart Association
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