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https://www.readbyqxmd.com/read/28510644/temporal-trends-in-acute-myocardial-infarction-presentation-and-association-with-use-of-cardioprotective-drugs-a-nationwide-registry-based-study
#1
Laerke Smedegaard, Mette Gitz Charlot, Gunnar Hilmar Gislason, Peter Riis Hansen
AIM: The present study aimed to investigate temporal trends in myocardial infarction (MI) presentation with or without ST-segment elevation (STE) and the association with use of cardioprotective drugs prior to admission. METHODS AND RESULTS: Using individual-level linkage of data from Danish nationwide registries, we identified all patients 30 years or older admitted with a first-time MI in the period 2003-2012, and their use of cardioprotective drugs 6 months prior to admission...
May 16, 2017: European Heart Journal. Cardiovascular Pharmacotherapy
https://www.readbyqxmd.com/read/28500377/reliability-of-echocardiographic-speckle-tracking-derived-bi-atrial-strain-assessment-under-different-hemodynamic-conditions
#2
Mahdi Sareban, Tabea Perz, Franziska Macholz, Bernhard Reich, Peter Schmidt, Sebastian Fried, Heimo Mairbäurl, Marc M Berger, Josef Niebauer
The aim of this study was to assess intra- and inter-observer variability of left (LA) and right atrial (RA) strain indices obtained by two-dimensional speckle-tracking echocardiography (2D-STE) in a healthy group of individuals at low-altitude and after rapid ascent to high-altitude in order to provoke altered systemic and pulmonary hemodynamics otherwise seen in various cardiac diseases. Twenty healthy subjects underwent transthoracic echocardiography during a baseline examination at low-altitude (424 m) as well as 7, 20 and 44 h after arrival at high-altitude (4559 m)...
May 12, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28497899/replacing-warfarin-with-a-novel-oral-anticoagulant-risk-of-recurrent-bleeding-and-stroke-in-patients-with-warfarin-ineligible-or-failure-in-patients-with-atrial-fibrillation-the-roar-study
#3
Mohit K Turagam, Valay Parikh, Muhammad R Afzal, Rakesh Gopinnathanair, Madhav Lavu, Arun Kanmanthareddy, Jayasree Pillarisetti, Madhu Reddy, Donita Atkins, Sudharani Bommana, Melissa Jaeger, Courtney Jeffery, Sanghamitra Mohanty, Pasquale Santangeli, Jie Cheng, Luigi Dibiase, Calambur Narasimhan, Andrea Natale, Dhanunjaya Lakkireddy
BACKGROUND: A significant proportion of patients treated with warfarin for atrial fibrillation (AF) become warfarin ineligible (WI) due to major bleeding events (MBE) or systemic thromboembolism (STE). We report a large multicenter real-world experience of the use of DOACs in these WI patients. METHODS: We report the outcomes of 263 WI patients treated with DOACs. The primary objective was to evaluate clinical outcomes of STE and MBE with DOACs. Secondary objective was to assess clinical predictors of repeat MBE and STE on DOACs...
May 12, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28497844/echocardiographic-evaluation-of-right-ventricular-systolic-function-the-traditional-and-innovative-approach
#4
Dorota Smolarek, Marcin Gruchała, Wojciech Sobiczewski
Estimation of right ventricular (RV) performance still remains technically challenging due to its anatomical and functional distinctiveness. The current guidelines for the echocardiographic quantification of RV function recommend using multiple indices to describe the RV in a thorough and comprehensive manner, such as RV index of myocardial performance, tricuspid annular plane systolic excursion, fractional area change, Doppler tissue imaging-derived tricuspid lateral annular systolic velocity (S'-wave), three-dimensional RV ejection fraction (3D RVEF), longitudinal strain (RVLS)/strain rate by speckle-tracking echocardiography (STE)...
May 12, 2017: Cardiology Journal
https://www.readbyqxmd.com/read/28497431/effect-of-catheter-based-renal-denervation-on-left-ventricular-function-mass-and-un-twist-with-two-dimensional-speckle-tracking-echocardiography
#5
Lida Feyz, Bas M van Dalen, Marcel L Geleijnse, Nicolas M Van Mieghem, Ron T van Domburg, Joost Daemen
BACKGROUND: Speckle tracking echocardiography (STE) is an echocardiography modality that is able to measure left ventricular (LV) characteristics, including rotation, strain and strain rate. Strain measures myocardial fibre contraction and relaxation. This study aims to assess the effect of renal sympathetic denervation (RDN) on functional myocardial parameters, including STE, and to identify potential differences between responders and non-responders. METHODS: The study population consisted of 31 consecutive patients undergoing RDN in the context of treatment for resistant hypertension...
May 11, 2017: Journal of Echocardiography
https://www.readbyqxmd.com/read/28492566/-speckle-tracking-echocardiography-a-practical-guide
#6
Matteo Cameli, Sergio Mondillo, Maurizio Galderisi, Giulia Elena Mandoli, Piercarlo Ballo, Stefano Nistri, Verdiana Capo, Flavio D'Ascenzi, Antonello D'Andrea, Roberta Esposito, Sabina Gallina, Roberta Montisci, Giuseppina Novo, Andrea Rossi, Donato Mele, Eustachio Agricola
Speckle tracking echocardiography (STE) has recently emerged as a quantitative technique to accurately estimate myocardial function. By the analysis of the motion of speckles in the two-dimensional ultrasonic image, this technique allows a non-Doppler angle-independent objective analysis of myocardial deformation, with the possibility to quantify thickening, shortening and rotation dynamics of cardiac function. Since this technique does not require Doppler imaging, the analysis is relatively angle-independent and is marginally affected by cardiac in-plane motion artifacts...
April 2017: Giornale Italiano di Cardiologia
https://www.readbyqxmd.com/read/28490455/speckle-tracking-echocardiography-in-acute-lupus-myocarditis-comparison-to-conventional-echocardiography
#7
Riëtte du Toit, Phillip G Herbst, Annari van Rensburg, Hendrik W Snyman, Helmuth Reuter, Anton F Doubell
AIMS: Lupus myocarditis occurs in 5-10% of patients with systemic lupus erythematosus (SLE). No single feature is diagnostic of lupus myocarditis. Speckle tracking echocardiography (STE) can detect sub-clinical left ventricular dysfunction in SLE patients, with limited research on its utility in clinical lupus myocarditis. We report on STE in comparison to conventional echocardiography in patients with clinical lupus myocarditis. METHODS AND RESULTS: A retrospective study was done at a tertiary referral hospital in South Africa...
May 10, 2017: Echo Research and Practice
https://www.readbyqxmd.com/read/28490257/tissue-distribution-and-elimination-of-deoxynivalenol-and-ochratoxin-a-in-dietary-exposed-atlantic-salmon-salmo-salar
#8
Aksel Bernhoft, Helga R Høgåsen, Grethe Rosenlund, Lada Ivanova, Marc H G Berntssen, Jan Alexander, Gunnar Sundstøl Eriksen, Christiane Kruse Fæste
Post-smolt Atlantic salmon, were fed standard feed with added 2 or 6 mg/kg pure deoxynivalenol (DON), 0.8 or 2.4 mg/kg pure ochratoxin A (OTA), or no added toxins, for up to eight weeks. The experiments were performed in duplicate tanks with 25 fish each per diet group, and the feed was given for three two-hour periods per day. After three, six and eight weeks ten fish from each diet group were sampled. In the following hours after the last feeding at eight weeks, toxin elimination was studied by sampling three fish per diet group at five time points...
May 11, 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/28480564/distribution-of-strain-patterns-in-children-with-dilated-cardiomyopathy
#9
Susanna L den Boer, Gideon J du Marchie Sarvaas, Liselotte M Klitsie, Gabriëlle G van Iperen, Ronald B Tanke, Willem A Helbing, Ad P C M Backx, Lukas A J Rammeloo, Michiel Dalinghaus, Arend D J Ten Harkel
OBJECTIVES: This study aimed to evaluate the predicting value of quantitative and qualitative dyssynchrony parameters as assessed by two-dimensional speckle tracking echocardiography (STE) on outcome in children with dilated cardiomyopathy (DCM). Furthermore, the reproducibility of these parameters was investigated. BACKGROUND: In previous studies in adults with heart failure, several dyssynchrony parameters have been shown to be a valuable predictor of clinical outcome...
May 7, 2017: Echocardiography
https://www.readbyqxmd.com/read/28472816/wocn-2016-guideline-for-prevention-and-management-of-pressure-injuries-ulcers-an-executive-summary
#10
(no author information available yet)
This article provides an executive summary of recommendations from the 2016 Guideline for Prevention and Management of Pressure Ulcers (Injuries) published by the Wound, Ostomy and Continence Nurses Society (WOCN). It presents an overview of the process used to update and develop the guideline, and lists the specific recommendations from the guideline for assessment, prevention, and treatment of pressure injuries. The guideline is a resource for physicians, nurses, therapists, and other healthcare professionals who work with adults who have/or are at risk for pressure injuries...
May 2017: Journal of Wound, Ostomy, and Continence Nursing
https://www.readbyqxmd.com/read/28472676/biotransformation-of-the-mycotoxin-enniatin-b1-in-pigs-a-comparative-in-vitro-and-in-vivo-approach
#11
Lada Ivanova, Silvio Uhlig, Mathias Devreese, Siska Croubels, Christiane Kruse Fæste
Enniatins (ENNs) are hexadepsipeptidic mycotoxins produced by Fusarium species. They occur in mg/kg levels in grain from Northern climate areas. Major ENNs such as ENN B and B1 have shown considerable cytotoxicity in different in vitro test systems. To adequately assess exposure and in vivo toxicity the toxicokinetic properties need to be investigated. The present study describes the metabolism of ENN B1 both in vitro and in vivo in pigs, comparing metabolites found in vitro in experiments with liver microsomes from different pig strains to those found in the plasma of pigs after single oral or intravenous application of ENN B1...
May 1, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28471536/assessment-of-subtle-cardiac-dysfunction-in-patients-with-frequent-premature-ventricular-complexes-by-real-time-three-dimensional-speckle-tracking-echocardiography
#12
Yunlong Ling, Quan Wan, Qingxing Chen, Wenqing Zhu
BACKGROUND: To evaluate subtle and early premature ventricular complex (PVC)-induced ventricular impairment in patients with frequent PVCs and without structural heart disease by real-time 3-dimensional (3D) speckle tracking echocardiography (RT3D-STE). HYPOTHESIS: Patients with frequent premature ventricular complexes with normal left ventricular ejection fraction have subtle left ventricular dysfunction. METHODS: Forty patients (22 male) with a single source of frequent PVCs and 40 healthy controls (24 male) underwent assessment by conventional 2-dimensional (2D) echocardiography and RT3D-STE...
May 4, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28467356/akr1c1-as-a-biomarker-for-differentiating-the-biological-effects-of-combustible-from-non-combustible-tobacco-products
#13
Sangsoon Woo, Hong Gao, David Henderson, Wolfgang Zacharias, Gang Liu, Quynh T Tran, G L Prasad
Smoking has been established as a major risk factor for developing oral squamous cell carcinoma (OSCC), but less attention has been paid to the effects of smokeless tobacco products. Our objective is to identify potential biomarkers to distinguish the biological effects of combustible tobacco products from those of non-combustible ones using oral cell lines. Normal human gingival epithelial cells (HGEC), non-metastatic (101A) and metastatic (101B) OSCC cell lines were exposed to different tobacco product preparations (TPPs) including cigarette smoke total particulate matter (TPM), whole-smoke conditioned media (WS-CM), smokeless tobacco extract in complete artificial saliva (STE), or nicotine (NIC) alone...
May 3, 2017: Genes
https://www.readbyqxmd.com/read/28460689/a-new-4-variable-formula-to-differentiate-normal-variant-st-segment-elevation-in-v2-v4-early-repolarization-from-subtle-left-anterior-descending-coronary-occlusion-adding-qrs-amplitude-of-v2-improves-the-model
#14
Brian E Driver, Ayesha Khalil, Timothy Henry, Faraz Kazmi, Amina Adil, Stephen W Smith
INTRODUCTION: Precordial normal variant ST elevation (NV-STE), previously often called "early repolarization," may be difficult to differentiate from subtle ischemic STE due to left anterior descending (LAD) occlusion. We previously derived and validated a logistic regression formula that was far superior to STE alone for differentiating the two entities on the ECG. The tool uses R-wave amplitude in lead V4 (RAV4), ST elevation at 60 ms after the J-point in lead V3 (STE60V3) and the computerized Bazett-corrected QT interval (QTc-B)...
April 19, 2017: Journal of Electrocardiology
https://www.readbyqxmd.com/read/28455877/assessment-of-left-atrial-deformation-and-function-by-2-dimensional-speckle-tracking-echocardiography-in-healthy-dogs-and-dogs-with-myxomatous-mitral-valve-disease
#15
M Baron Toaldo, G Romito, C Guglielmini, A Diana, N G Pelle, B Contiero, M Cipone
BACKGROUND: The assessment of left atrial (LA) function by 2-dimensional speckle tracking echocardiography (STE) holds important clinical implications in human medicine. Few similar data are available in dogs. OBJECTIVES: To assess LA function by STE in dogs with and without myxomatous mitral valve disease (MMVD), analyzing LA areas, systolic function, and strain. ANIMALS: One hundred and fifty dogs were divided according to the American College of Veterinary Internal Medicine classification of heart failure: 23 dogs in class A, 52 in class B1, 36 in class B2, and 39 in class C + D...
May 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28455633/evaluation-of-left-ventricular-myocardial-mechanics-by-three-dimensional-speckle-tracking-echocardiography-in-the-patients-with-different-graded-coronary-artery-stenosis
#16
Lin Li, Ping-Yang Zhang, Hong Ran, Jing Dong, Ling-Ling Fang, Qian-Shan Ding
To investigate the relationship between left ventricular (LV) myocardial mechanics evaluated by three-dimensional speckle tracking echocardiography (3D-STE) and degree of coronary artery stenosis in patients with coronary artery disease (CAD). Ninety-seven suspected CAD patients without LV regional wall motion abnormality (RWMA) observed visually form traditional echocardiography were divided into four groups according to coronary artery angiography (CAG): 23 patients in slight stenosis group [stenosis rate (SR) ≤25%], 26 patients in mild stenosis group (25< SR ≤50%), 28 patients in moderate stenosis group (50< SR ≤75%), and 20 patients in severe stenosis group (SR >75%)...
April 28, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28451088/the-association-of-right-coronary-artery-conus-branch-size-and-course-with-st-segment-elevation-of-right-precordial-leads-and-clinical-outcome-of-acute-anterior-myocardial-infarction
#17
Samad Ghaffari, Mohammadreza Taban Sadeghi, Mohammad Hossein Sayyadi
Introduction: Coronary artery disease is the leading cause of death worldwide and electrocardiogram (ECG) is a reliable diagnostic tool to determine a myocardial infarction. The present study tried to compare the relationship between the ECG findings and angiographic findings in patients with acute anterior myocardial infarction. Methods: Seventy-four patients with acute anterior ST elevation myocardial infarction (Ant- STEMI) presenting to the emergency room in the first 12 hours after the onset of symptoms were studied...
2017: Journal of Cardiovascular and Thoracic Research
https://www.readbyqxmd.com/read/28431690/elevated-hemi-diaphragms-as-a-cause-of-st-segment-elevation-a-case-report-and-review-of-literature
#18
Manmohan Singh, Aditya Sood, Mobeen Ur Rehman, Mahmoud Othman, Luis Afonso
While ST-segment elevation (STE) on ECG is widely recognized as representing myocardial infarction or injury such as coronary occlusion or pericarditis, STE may occasionally ensue from non-cardiac etiologies. Indeed, gastrointestinal disorders causing STE are not well documented in the literature. We present a case wherein extreme abdominal distension and hemi-diaphragm elevation resulted in extrinsic cardiac and epicardial coronary compression manifesting as STE. Subsequent relief of the abdominal distension resulted in resolution of STE representing a noncoronary cause of STE...
April 6, 2017: Journal of Electrocardiology
https://www.readbyqxmd.com/read/28428548/antiviral-activities-of-schizonepeta-tenuifolia-briq-against-enterovirus-71-in-vitro-and-in-vivo
#19
Sin-Guang Chen, Mei-Ling Cheng, Kuan-Hsing Chen, Jim-Tong Horng, Ching-Chuan Liu, Shih-Min Wang, Hiroaki Sakurai, Yann-Lii Leu, Shulhn-Der Wang, Hung-Yao Ho
No effective drug is currently available for treatment of enterovirus 71 (EV71) infection. Schizonepeta tenuifolia Briq. (ST) has been used as a herbal constituent of traditional Chinese medicine. We studied whether the aqueous extract of Schizonepeta tenuifolia Briq (STE) has antiviral activity. STE inhibited replication of EV71, as evident by its ability to diminish plaque formation and cytopathic effect induced by EV71, and to inhibit the synthesis of viral RNA and protein. Moreover, daily single-dose STE treatment significantly improved the survival of EV71-infected mice, and ameliorated the symptoms...
April 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28424890/left-atrial-electromechanical-conduction-time-predicts-atrial-fibrillation-in-patients-with-mitral-stenosis-a-5-year-follow-up-speckle-tracking-echocardiography-study
#20
Ozkan Candan, Cetin Gecmen, Arzu Kalayci, Cem Dogan, Emrah Bayam, Mehmet Ozkan
Prolonged left atrial electromechanical conduction time is related with atrial electrical remodeling, and is predictive of the development of atrial fibrillation. The aim of our study was to examine whether left atrial electromechanical conduction time (EMT) and left atrial strain as measured by speckle tracking echocardiography (STE) are predictors for the development of atrial fibrillation (AF) in patients with mitral stenosis (MS) at 5-year follow-up. A total of 81 patients (61% females; mean age 38.1 ± 12...
April 19, 2017: International Journal of Cardiovascular Imaging
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