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adolescent idiopathic scoliosis

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https://www.readbyqxmd.com/read/27933320/genetics-and-pathogenesis-of-idiopathic-scoliosis
#1
REVIEW
A Grauers, E Einarsdottir, P Gerdhem
Idiopathic scoliosis (IS), the most common spinal deformity, affects otherwise healthy children and adolescents during growth. The aetiology is still unknown, although genetic factors are believed to be important. The present review corroborates the understanding of IS as a complex disease with a polygenic background. Presumably IS can be due to a spectrum of genetic risk variants, ranging from very rare or even private to very common. The most promising candidate genes are highlighted.
2016: Scoliosis and Spinal Disorders
https://www.readbyqxmd.com/read/27927574/untreated-thoracic-curve-in-adult-idiopathic-scoliosis-what-are-patients-concerns
#2
Javier Pizones, Mar Pérez Martin-Buitrago, Francisco Javier Sánchez Perez-Grueso, Ferran Pellisé, Ahmet Alanay, Ibrahim Obeid, Frank Kleinstück, Emre R Acaroglu
STUDY DESIGN: Retrospective two-cohort comparative analysis of data collected prospectively. OBJECTIVES: To analyze a cohort of patients with untreated thoracic curves of an adult multicenter deformity database [European spine study group (ESSG)], describe patient characteristics and concerns, and establish the rate and motivations for surgical intervention. SUMMARY OF BACKGROUND DATA: Idiopathic thoracic curves have a significant clinical and socioeconomic impact during adolescence...
November 2016: Spine Deformity
https://www.readbyqxmd.com/read/27927573/effect-of-surgical-fusion-on-volitional-weight-shifting-in-individuals-with-adolescent-idiopathic-scoliosis
#3
Nikhil T Kurapati, Joseph J Krzak, Adam Graf, Sahar Hassani, Sergey Tarima, Peter F Sturm, Kim Hammerberg, Purnendu Gupta, Gerald F Harris
STUDY DESIGN: Prospective. OBJECTIVES: The goals of this study were to (1) evaluate the differences in weightbearing symmetry between individuals with adolescent idiopathic scoliosis (AIS) and typically developing controls; (2) observe the effect of posterior spinal fusion and instrumentation (PSFI) on volitional weight-shifting at 1 and 2 years postoperatively; and (3) evaluate whether lowest instrumented fusion level (ie, lowest instrumented vertebra [LIV]) in PSFI has an effect on volitional weight-shifting...
November 2016: Spine Deformity
https://www.readbyqxmd.com/read/27927572/the-spinopelvic-geometry-in-different-lenke-curve-types-of-adolescent-idiopathic-scoliosis
#4
M Farshad, S Catanzaro, S L Schmid
BACKGROUND: The Lenke classification is well established in differentiation of curve types in adolescent idiopathic scoliosis (AIS) and guides selection of fusion levels. However, to date, it has neglected the spinopelvic parameters that have been associated with compensatory mechanisms in balancing the human erect posture and adjacent segment problems after spinal fusion. The aim of this study was to investigate spinopelvic parameters in different types of AIS curves. MATERIAL AND METHODS: Preoperative whole-spine radiographs from 100 patients with AIS were reviewed and the curves were classified according to Lenke...
November 2016: Spine Deformity
https://www.readbyqxmd.com/read/27927571/a-comparative-analysis-among-the-srs-m-m-nis-and-kid-databases-for-the-adolescent-idiopathic-scoliosis
#5
Nathan J Lee, Javier Z Guzman, Jun Kim, Branko Skovrlj, Christopher T Martin, Andrew J Pugely, Yubo Gao, John M Caridi, Sergio Mendoza-Lattes, Samuel K Cho
STUDY DESIGN: Retrospective cohort analysis. OBJECTIVES: A growing number of publications have utilized the Scoliosis Research Society (SRS) Morbidity and Mortality (M&M) database, but none have compared it to other large databases. The objective of this study was to compare SRS complications with those in administrative databases. SUMMARY OF BACKGROUND DATA: The Nationwide Inpatient Sample (NIS) and Kid's Inpatient Database (KID) captured a greater number of overall complications while the SRS M&M data provided a greater incidence of spine-related complications following adolescent idiopathic scoliosis (AIS) surgery...
November 2016: Spine Deformity
https://www.readbyqxmd.com/read/27927566/the-development-of-thoracic-vertebral-sagittal-morphology-during-childhood
#6
Ozgur Dede, Kadir Büyükdogan, Halil Gökhan Demirkıran, Erhan Akpınar, Muharrem Yazıcı
STUDY DESIGN: This is a cross-sectional descriptive study objectives to describe normal development of thoracic vertebrae during childhood and document contribution of individual vertebral shape to the sagittal alignment. SUMMARY OF BACKGROUND DATA: Sagittal spinal alignment changes during growth. The changes in sagittal alignment during adolescent growth spurt as well as the individual shapes of thoracic vertebrae have been implicated as factors for the development of adolescent idiopathic scoliosis (AIS)...
November 2016: Spine Deformity
https://www.readbyqxmd.com/read/27927551/reliability-and-validity-testing-of-a-danish-translated-version-of%C3%A2-spinal%C3%A2-appearance-questionnaire-saq-v-1-1
#7
Ane Simony, Leah Y Carreon, Karen Hoejmark Hansen, Mikkel O Andersen
STUDY DESIGN: Cross-sectional. OBJECTIVE: To develop a psychometrically reliable and valid Danish version of the Spinal Appearance Questionnaire (SAQ). SUMMARY OF BACKGROUND DATA: The SAQ was developed as a disease-specific measure of quality of life in patients with adolescent idiopathic scoliosis (AIS), specifically for younger patients, as it has more visual cues than verbal questions. A reliable and valid Danish Version is not available...
March 2016: Spine Deformity
https://www.readbyqxmd.com/read/27927549/deep-spine-infection-after-acupuncture-in-the-setting-of-spinal-instrumentation
#8
Alexandra K Callan, Jennifer M Bauer, Jeffrey E Martus
BACKGROUND: Acupuncture can be used to manage chronic pain. The most common complications related to acupuncture include pain, bruising, bleeding, or symptom exacerbation. Rarely, more serious adverse events occur, including infection, pneumothorax, septic arthritis, and peripheral nerve injury. To our knowledge, there are no reports of complications associated with acupuncture following spinal instrumentation. PURPOSE: To report a case of deep infection as a rare complication of acupuncture following posterior spinal fusion for adolescent idiopathic scoliosis...
March 2016: Spine Deformity
https://www.readbyqxmd.com/read/27927546/new-eos-imaging-protocol-allows-a-substantial-reduction-in-radiation-exposure-for-scoliosis-patients
#9
Peter O Newton, Yash Khandwala, Carrie E Bartley, Fredrick G Reighard, Tracey P Bastrom, Burt Yaszay
STUDY DESIGN: Prospective. OBJECTIVE: To evaluate the reliability of three-dimensional (3D) spinal models from Micro Dose EOS x-rays compared to standard, Low Dose EOS x-rays utilized for evaluating patients with adolescent idiopathic scoliosis (AIS). SUMMARY OF BACKGROUND DATA: There is a strong suggestion that radiation exposure to scoliosis patients can be further reduced. METHODS: Sixty AIS patients who received biplanar, posteroanterior, and lateral standard Low Dose spine x-rays in our EOS imaging unit (∼0...
March 2016: Spine Deformity
https://www.readbyqxmd.com/read/27927544/assessment-of-lowest-instrumented-vertebra-tilt-on-radiographic-measurements-in-lenke-c-modifier-curves-undergoing-selective-thoracic-fusion-in-adolescent-idiopathic-scoliosis
#10
David L Skaggs, Derek A Seehausen, Kent T Yamaguchi, Raymond J Hah, Margaret L Wright, David B Bumpass, Han J Kim, Lindsay M Andras, Michael G Vitale, Lawrence G Lenke
STUDY DESIGN: Multicenter, retrospective cohort study. OBJECTIVES: The purpose of this study is to determine how the amount of residual lowest instrumented vertebra (LIV) tilt correlates with radiographic measurements. SUMMARY OF BACKGROUND DATA: When performing a selective thoracic posterior spinal fusion for adolescent idiopathic scoliosis (AIS), the LIV may be tilted into the lumbar curve or made horizontal. METHODS: This is a multicenter retrospective study of 33 consecutive patients with AIS, Lenke types 1 to 4, lumbar modifier C, and a minimum follow-up of 2 years, who underwent selective thoracic posterior spinal fusions...
March 2016: Spine Deformity
https://www.readbyqxmd.com/read/27927543/curve-magnitude-in-patients-referred-for-evaluation-of-adolescent-idiopathic-scoliosis-five-years-experience-from-a-system-without-school-screening
#11
Søren Ohrt-Nissen, Dennis W Hallager, Jeppe L Henriksen, Martin Gehrchen, Benny Dahl
STUDY DESIGN: Retrospective cross-sectional study. OBJECTIVES: To analyze the referral pattern of patients with adolescent idiopathic scoliosis (AIS) in a tertiary hospital in a nationalized health care system without school screening and to compare curve magnitude on referral with results reported in the literature. SUMMARY OF BACKGROUND DATA: In Denmark, school screening for AIS has not been in effect for more than two decades, and there is limited knowledge of curve magnitude and pattern of referral to specialized treatment in our country...
March 2016: Spine Deformity
https://www.readbyqxmd.com/read/27927521/reoperation-rates-after-long-posterior-spinal-fusion-use-of-recombinant-bone-morphogenetic-protein-in-idiopathic-and-non-idiopathic-scoliosis
#12
Justin C Paul, Baron S Lonner, Shaleen Vira, Ian David Kaye, Thomas J Errico
INTRODUCTION: Bone morphogenetic protein (BMP) can increase the likelihood of solid arthrodesis in spinal surgery. This would imply fewer reoperations for pseudarthrosis, but small cohort sizes are inadequate to monitor these events. We sought to examine adolescent idiopathic (AIS) and non-idiopathic scoliosis (NIS) for reoperation events with and without the use of BMP using a large statewide database. METHODS: The 2008-2011 New York State Inpatient Database was queried using International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) codes...
July 2016: Spine Deformity
https://www.readbyqxmd.com/read/27927519/a-rapid-recovery-pathway-for-adolescent-idiopathic-scoliosis-that-improves-pain-control-and-reduces-time-to-inpatient-recovery-after-posterior-spinal-fusion
#13
Alex L Gornitzky, John M Flynn, Wallis T Muhly, Wudbhav N Sankar
STUDY DESIGN: Retrospective comparative cohort. OBJECTIVES: To determine if a standardized multimodal analgesic and rehabilitation protocol (rapid recovery pathway [RRP]) in adolescent idiopathic scoliosis (AIS) patients undergoing posterior spinal fusion (PSF) could improve pain control, reduce opioid-related complications, and expedite early mobilization. BACKGROUND: Several reports have described postoperative recovery pathways for AIS patients undergoing PSF that shorten length of stay (LOS) without reporting the impact such pathways might have on patients' pain or quality of recovery...
July 2016: Spine Deformity
https://www.readbyqxmd.com/read/27927516/preoperative-mrsa-screening-in-pediatric-spine-surgery-a-helpful-tool-or-a-waste-of-time-and-money
#14
Scott J Luhmann, June C Smith
OBJECTIVES: To review the use of preoperative screening for Staphylococcus aureus for all pediatric spine procedures that was instituted at our facility in a multimodal approach to decrease the frequency of postoperative wound infections. SUMMARY OF BACKGROUND DATA: Four years ago at our facility, a multimodal approach to decrease the frequency of postoperative infections after pediatric spine surgery was instituted. METHODS: A single-center, single-surgeon pediatric spine surgery database was queried to identify all patients who had preoperative S...
July 2016: Spine Deformity
https://www.readbyqxmd.com/read/27927513/biomechanical-assessment-of-providence-nighttime-brace-for-the-treatment-of-adolescent-idiopathic-scoliosis
#15
Amjad Sattout, Julien Clin, Nikita Cobetto, Hubert Labelle, Carl-Eric Aubin
STUDY DESIGN: Biomechanical study of the Providence brace for the treatment of adolescent idiopathic scoliosis (AIS). OBJECTIVES: To model and assess the effectiveness of Providence nighttime brace. SUMMARY OF BACKGROUND DATA: Providence nighttime brace is an alternative to traditional daytime thoracolumbosacral orthosis for the treatment of moderate scoliotic deformities. It applies three-point pressure to reduce scoliotic curves. The biomechanics of the supine position and Providence brace is still poorly understood...
July 2016: Spine Deformity
https://www.readbyqxmd.com/read/27927503/curve-progression-in-adolescent-idiopathic-scoliosis-with-a-minimum-of%C3%A2-2-years-follow-up-after-completed-brace-weaning-with-reference-to%C3%A2-the-srs-standardized-criteria
#16
Benlong Shi, Jing Guo, Saihu Mao, Zhiwei Wang, Fiona W P Yu, Kwong Man Lee, Bobby K W Ng, Zezhang Zhu, Yong Qiu, Jack C Y Cheng, Tsz Ping Lam
STUDY DESIGN: A retrospective study. OBJECTIVES: To investigate curve evolution after brace weaning in adolescent idiopathic scoliosis (AIS) with reference to the Scoliosis Research Society (SRS) criteria. SUMMARY OF BACKGROUND DATA: Previous studies mainly focused on curve evolution during bracing in AIS. However, curve progression after brace weaning was not well addressed. METHODS: Braced AIS girls followed up for at least 2 years after brace weaning were reviewed...
May 2016: Spine Deformity
https://www.readbyqxmd.com/read/27927501/morphometric-analysis-of-the-thoracic-intervertebral-foramen-osseous-anatomy-in-adolescent-idiopathic-scoliosis-using-low-dose-computed-tomography
#17
Thorbjorn J Loch-Wilkinson, Maree T Izatt, Robert D Labrom, Geoffrey N Askin, Mark J Pearcy, Clayton J Adam
PURPOSE: The dimensions of the thoracic intervertebral foramen in adolescent idiopathic scoliosis (AIS) have not previously been quantified. Better understanding of the dimensions of the foramen may be useful in surgical planning. This study describes a reproducible method for measurement of the thoracic foramen in AIS using computed tomography (CT). METHODS: In 23 preoperative female patients with Lenke 1 type AIS with right-side convexity major curves confined to the thoracic spine the foraminal height (FH), foraminal width (FW), pedicle to superior articular process distance (P-SAP), and cross-sectional foraminal area (FA) were measured using multiplanar reconstructed CT...
May 2016: Spine Deformity
https://www.readbyqxmd.com/read/27922579/srs-22r-scores-in-non-operated-adolescent-idiopathic-scoliosis-patients-with-curves-greater-than-forty-degrees
#18
W Timothy Ward, Nicole A Friel, Tanya S Kenkre, Maria M Brooks, Joanne A Londino, James W Roach
STUDY DESIGN: Case control comparative series OBJECTIVE.: Describe surgical range adolescent idiopathic scoliosis (AIS) patients electing to forgo surgery and compare health related quality of life outcomes to a similar cohort of operated AIS patients by the same single surgeon. SUMMARY OF BACKGROUND DATA: No data have been published either documenting SRS-22r scores of non-operated patients with curves ≥ 40° or comparing these scores to a demographically similar operated cohort...
December 2, 2016: Spine
https://www.readbyqxmd.com/read/27919651/computer-assisted-skip-pedicle-screw-fixation-for-adolescent-idiopathic-scoliosis
#19
Masashi Uehara, Jun Takahashi, Shugo Kuraishi, Masayuki Shimizu, Shota Ikegami, Toshimasa Futatsugi, Hiroki Oba, Hiroyuki Kato
STUDY DESIGN: A retrospective single-center and single-surgeon study. OBJECTIVES: This study investigated the clinical and radiological results of skip pedicle screw fixation for adolescent idiopathic scoliosis (AIS). SUMMARY OF BACKGROUND DATA: At present, the generally used technique for pedicle screw fixation for the surgical correction of AIS entails inserting a pedicle screw into every segment on the corrective side and into every or every other segment on the supportive side...
December 2, 2016: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/27911281/polymorphisms-in-promoter-regions-of-mmp-3-and-il-6-genes-are-not-associated-to-adolescent-idiopathic-scoliosis-ais-gender-bias
#20
Wenyuan Sui, Junlin Yang, Zifang Huang, Qifei Wang, Hengwei Fan, Yaolong Deng
STUDY DESIGN: A retrospective study in Chinese Han people. PURPOSE: To explore whether promoter polymorphisms of matrix metalloproteinases-3 (MMP-3) (rs3025058) and interleukin-6(IL-6) (rs1800795) genes are associated to AIS gender bias. METHODS: A total of 200 patients (100 boys and 100 girls) with AIS and 200 healthy age-matched adolescents were recruited from July 2008 to August 2013 in our scoliosis center. All AIS patients had Cobb angles larger than 20°, average 43 ± 3...
November 25, 2016: Journal of Back and Musculoskeletal Rehabilitation
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