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https://www.readbyqxmd.com/read/29908271/twofold-enhanced-dispersin-b-activity-by-n-terminal-fusion-to-silver-binding-peptide-for-biofilm-eradication
#1
Kuan-Jung Chen, Cheng-Kang Lee
Dispersin B (DspB) has shown a great potential for the hydrolysis of polymeric β-1,6-N-acetyl-d-glucosamine (PNAG) to disperse the biofilms formed by various bacteria but with no killing activity. Here we have investigated whether a silver-binding peptide (AgBP) fused to DspB can induce the in situ formation of silver nanoparticles (AgNP) and conjugated to the structure of DspB so that the bacteria cells released from the dispersed biofilm will be killed by the conjugated AgNP. However, the desired conjugate could be obtained because of the silver ions itself was found to precipitate DspB...
June 13, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29907598/clinical-response-of-the-novel-activating-alk-i1171t-mutation-in-neuroblastoma-to-the-alk-inhibitor-ceritinib
#2
Jikui Guan, Susanne Fransson, Joachim Tetteh T Siaw, Diana Treis, Jimmy Van den Eynden, Damini Chand, Ganesh Umapathy, Petter Svenberg, Kristina Ruuth, Sandra Wessman, Alia Shamikh, Hans Jacobsson, Lena Gordon, Jakob Stenman, Erik Larsson, Par-Johan Svensson, Magnus Hansson, Tommy Martinsson, Per Kogner, Ruth H Palmer, Bengt Hallberg
Tumors with Anaplastic Lymphoma Kinase (ALK) fusion rearrangements, including non-small cell lung cancer and anaplastic large cell lymphoma, are highly sensitive to ALK tyrosine kinase inhibitors (TKIs), underscoring the notion that such cancers are addicted to ALK activity. While mutations in ALK are heavily implicated in childhood neuroblastoma, response to the ALK TKI crizotinib has been disappointing. Embryonal tumors in patients with DNA repair defects such as Fanconi anemia (FA) often have a poor prognosis, due to lack of therapeutic options...
June 15, 2018: Cold Spring Harbor Molecular Case Studies
https://www.readbyqxmd.com/read/29907388/assessment-of-the-corticospinal-fiber-integrity-in-mirror-movement-disorder
#3
Bilgehan Solmaz, Mustafa Görkem Özyurt, Demir Berk Ata, Fulya Akçimen, Mohammed Shabsog, Kemal Sıtkı Türker, Hakkı Dalçik, Oktay Algin, Ayşe Nazlı Başak, Merve Özgür, Safiye Çavdar
Mirror movements are unintended movements occurring on one side of the body that mirror the contralateral voluntary ones. It has been proposed that mirror movements occur due to abnormal decussation of the corticospinal pathways. Using detailed multidisciplinary approach, we aimed to enlighten the detailed mechanism underlying the mirror movements in a case subject who is diagnosed with mirror movements of the hands and we compared the findings with the unaffected control subjects. To evaluate the characteristics of mirror movements, we used several techniques including whole exome sequencing, computed tomography, diffusion tensor imaging and transcranial magnetic stimulation...
June 12, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29906580/posterior-lumbar-interbody-fusion-vs-dynamic-hybrid-instrumentation-a-prospective-randomised-clinical-trial
#4
C Herren, M Simons, J Bredow, S Oikonomidis, L Westermann, R Sobottke, M J Scheyerer, M Pishnamaz, P Eysel, K Zarghooni, J Franklin, J Siewe
PURPOSE: The purpose of this study was to assess the radiological and clinical outcomes following lumbar fusion intervention and to compare both, the established posterior lumbar interbody fusion (PLIF)-technique and the dynamic hybrid instrumentation ('topping off'). METHODS: In this prospective randomised trial all patients presented with degenerative changes to the lumbar spine (L2-S1) were included and randomised in two groups: patients who underwent the 360°-fusion procedure in PLIF-technique (1, control group) and those patients who underwent fusion surgery with additional hybrid instrumentation (DTO, Zimmer, Inc...
June 12, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29905624/a-modified-posterior-c1-c2-fusion-technique-for-the-management-of-traumatic-odontoid-type-ii-fractures-by-using-intraoperative-spinal-navigation-mid-term-results
#5
Basem Ishak, Till Schneider, Valerie Gimmy, Andreas W Unterberg, Karl L Kiening
OBJECTIVES: To assess mid-term safety and efficacy of a modified Goel-Harms technique for the treatment of odontoid instabilities. DESIGN: Longitudinal prospective cohort study. SETTING: Urban Level 1 Trauma Center in Southwest Germany. PATIENTS/PARTICIPANTS: Orthopaedic and neurosurgical trauma patients older than 18 years admitted for ≤ 24 hours. MAIN OUTCOME MEASUREMENTS: The outcome was evaluated with respect to neurological outcome, radiological outcome and surgical complications...
June 4, 2018: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/29905520/coflex-interspinous-implant-placement-leading-to-synovial-cyst-development-case-report
#6
Seba Ramhmdani, Marc Comair, Camilo A Molina, Daniel M Sciubba, Ali Bydon
Interspinous process devices (IPDs) have been developed as less-invasive alternatives to spinal fusion with the goal of decompressing the spinal canal and preserving segmental motion. IPD implantation is proposed to treat symptoms of lumbar spinal stenosis that improve during flexion. Recent indications of IPD include lumbar facet joint syndrome, which is seen in patients with mainly low-back pain. Long-term outcomes in this subset of patients are largely unknown. The authors present a previously unreported complication of coflex (IPD) placement: the development of a large compressive lumbar synovial cyst...
June 15, 2018: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/29902946/silver-nanoparticles-inhibit-neural-induction-in-human-induced-pluripotent-stem-cells
#7
Shigeru Yamada, Daiju Yamazaki, Yasunari Kanda
Silver nanoparticles (AgNPs) have been widely used as consumer products due to their antibacterial activities. Despite their extensive use, AgNPs have been reported to cause various types of cytotoxicity, including neurotoxicity. However, the potential action of AgNPs on early fetal development has not been elucidated. This study determined the effects of AgNPs on neural induction in human induced pluripotent stem cells (iPSCs), used as a model for human fetal stage development. It was observed that exposure to AgNPs reduced the expression of several neural differentiation marker genes, including OTX2, an early biomarker for neurogenesis in iPSCs...
June 14, 2018: Nanotoxicology
https://www.readbyqxmd.com/read/29902826/anterior-cervical-fusion-with-stand-alone-trabecular-metal-cages-to-treat-cervical-myelopathy-caused-by-degenerative-disk-disease-observations-in-88-cases-with-minimum-12-month-follow-up
#8
Luciano Mastronardi, Raffaelino Roperto, Guglielmo Cacciotti, Francesco Calvosa
BACKGROUND:  Anterior cervical fusion (ACF) with autologous bone was reported > 50 years ago. The continuous development of materials with elastic properties close to that of the cortical bone improves induction of osteogenesis and simplifies the technique of interbody fusion. To determine the safety and efficiency of stand-alone trabecular metal (TM) (or porous tantalum) cages for ACF, we performed a retrospective analysis of 88 consecutive patients with one-level or two-level degenerative disk disease (DDD) causing cervical myelopathy treated by interbody fusion with stand-alone TM cages...
June 14, 2018: Journal of Neurological Surgery. Part A, Central European Neurosurgery
https://www.readbyqxmd.com/read/29902639/outpatient-anterior-cervical-discectomy-a-french-study-and-literature-review
#9
Antoine Gennari, Simon Mazas, Pierre Coudert, Olivier Gille, Jean-Marc Vital
INTRODUCTION: In France, surgery for lumbar disc herniation is now being done in the outpatient ambulatory setting at select facilities. However, surgery for the cervical spine in this setting is controversial because of the dangers of neck hematoma. We wanted to share our experience with performing ambulatory anterior cervical discectomy in 30 patients at our facility. RESULTS: Since 2014, 30 patients (16 men, 14 women; mean age of 47.2 years) with cervical radiculopathy due to single-level cervical disc disease (19 at C5-C6 and 11 at C6-C7) were operated at our ambulatory surgery center...
June 11, 2018: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/29902569/resolvin-e1-and-its-precursor-18r-hepe-restore-mitochondrial-function-in-inflammation
#10
Matthias Hecker, Natascha Sommer, Sebastian Foch, Andreas Hecker, Holger Hackstein, Martin Witzenrath, Norbert Weissmann, Werner Seeger, Konstantin Mayer
Inflammatory disorders such as sepsis are a major cause of morbidity and mortality. Mitochondrial dysfunction is considered a key factor in the pathogenesis of severe inflammation. In the present study, we aimed to investigate the impact of arachidonic acid, omega-3 (n-3) fatty acids, and n-3-derived lipid mediators 18R-HEPE and resolvin (Rv) E1 on mitochondrial function in experimental inflammation. The results revealed that, in contrast to n-6 and n-3 fatty acids, both 18R-HEPE and RvE1 possess anti-inflammatory and anti-apoptotic properties...
June 11, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29901833/the-energy-maintenance-theory-of-aging-maintaining-energy-metabolism-to-allow-longevity
#11
REVIEW
Snehal N Chaudhari, Edward T Kipreos
Fused, elongated mitochondria are more efficient in generating ATP than fragmented mitochondria. In diverse C. elegans longevity pathways, increased levels of fused mitochondria are associated with lifespan extension. Blocking mitochondrial fusion in these animals abolishes their extended longevity. The long-lived C. elegans vhl-1 mutant is an exception that does not have increased fused mitochondria, and is not dependent on fusion for longevity. Loss of mammalian VHL upregulates alternate energy generating pathways...
June 14, 2018: BioEssays: News and Reviews in Molecular, Cellular and Developmental Biology
https://www.readbyqxmd.com/read/29901538/concurrent-and-overlapping-surgery-perspectives-from-parents-of-adolescents-undergoing-spinal-posterior-instrumented-fusion-for-idiopathic-scoliosis
#12
Jessica Bryant, Alexander Markes, Tiana Woolridge, Dede Cerruti, Elizabeth Dzeng, Barbara Koenig, Mohammad Diab
STUDY DESIGN: Prospective cross-sectional survey. OBJECTIVE: To determine the perspectives of parents of patients undergoing posterior instrumented fusion for adolescent idiopathic scoliosis (AIS) regarding simultaneous surgery and trainee participation. SUMMARY OF BACKGROUND DATA: Simultaneous ("at the same time") surgery is under scrutiny by the public, government, payers and the medical community. The objective of this study is to determine the perspectives of parents of patients undergoing posterior instrumented fusion for adolescent idiopathic scoliosis...
June 12, 2018: Spine
https://www.readbyqxmd.com/read/29901537/an-evidence-based-approach-to-the-management-of-children-with-morquio-a-syndrome-presenting-with-craniocervical-pathology
#13
Nicole Williams, Alessandro Narducci, Deborah M Eastwood, Maureen Cleary, Dominic Thompson
STUDY DESIGN: Retrospective case series OBJECTIVE.: To review clinical and radiological outcomes of craniovertebral surgery in children with Morquio A syndrome (Mucopolysaccharidosis type IVA) and develop an evidence-based management algorithm. SUMMARY OF BACKGROUND DATA: Myelopathy secondary to craniovertebral pathology is a common cause of neurological disability in Morquio A syndrome. Previously unresolved surgical controversies include the value of surveillance, surgical indications and operative technique...
June 12, 2018: Spine
https://www.readbyqxmd.com/read/29900333/biometric-authentication-data-with-three-traits-using-compression-technique-hog-gmm-and-fusion-technique
#14
Balaka Ramesh Naidu, Maddali Surendra Prasad Babu
This paper presents a three trait identification model called multimodal recognition system developed by using different traits like face, finger and voice (Babu and Naidu, 2014, 2016; Balaka and Surendra, 2017) [1-3]. This system provides more security when compare to existing works. Initially, all the traits are followed by pre-processed, extract features using Histogram of oriented gradients (HOG), then apply Gaussian mixture model (GMM) for finding probability density function (PDF) values and then combining these features by using Score level fusion...
June 2018: Data in Brief
https://www.readbyqxmd.com/read/29899875/characterization-and-diagnostic-application-of-genomic-npm-alk-fusion-sequences-in-anaplastic-large-cell-lymphoma
#15
Manuela Krumbholz, Wilhelm Woessmann, Jakob Zierk, David Seniuk, Paolo Ceppi, Martin Zimmermann, Vijay Kumar Singh, Markus Metzler, Christine Damm-Welk
Nucleophosmin-anaplastic lymphoma kinase ( NPM-ALK) fusion genes resulting from the translocation t(2;5)(p23;q35) are present in almost 90% of childhood ALK-positive anaplastic large-cell lymphomas (ALCL). Detection and quantification of minimal disseminated disease (MDD) by measuring NPM-ALK fusion transcript levels in the blood provide independent prognostic parameters. Characterization of the genomic breakpoints provides insights into the pathogenesis of the translocation and allows for DNA-based minimal disease monitoring...
May 29, 2018: Oncotarget
https://www.readbyqxmd.com/read/29899761/precision-diagnostics-of-ewing-s-sarcoma-by-liquid-biopsy-circulating-ews-fli1-fusion-transcripts
#16
Matteo Allegretti, Beatrice Casini, Chiara Mandoj, Stefania Benini, Laurent Alberti, Mariangela Novello, Elisa Melucci, Laura Conti, Renato Covello, Edoardo Pescarmona, Giuseppe Maria Milano, Alessio Annovazzi, Vincenzo Anelli, Virginia Ferraresi, Roberto Biagini, Patrizio Giacomini
Background: Limited information is available on the applicative value of liquid biopsy (LB) in rare tumors, including Ewing's sarcoma (ES). The accepted precision diagnostics standards would greatly benefit from a non-invasive LB test monitoring pathognomonic gene rearrangements in the bloodstream. Methods: Tissue and blood samples were collected from six and four ES patients, respectively. Plasma was cleared by two successive rounds of centrifugation and stored frozen until RNA extraction by the QIAmp CNA kit...
2018: Therapeutic Advances in Medical Oncology
https://www.readbyqxmd.com/read/29899103/design-of-novel-hiv-1-2-fusion-inhibitors-with-efficient-therapeutic-efficacy-in-rhesus-monkey-models
#17
Huihui Chong, Jing Xue, Yuanmei Zhu, Zhe Cong, Ting Chen, Yan Guo, Qiang Wei, Yusen Zhou, Chuan Qin, Yuxian He
T-20 (enfuvirtide) is the only approved viral fusion inhibitor, which is used for treatment of HIV-1 infection; however, it has relatively low antiviral activity and easily induces drug resistance. We recently reported a T-20-based lipopeptide fusion inhibitor (LP-40) showing improved anti-HIV activity (Ding et al J Virol, 2017). In this study, we designed LP-50 and LP-51 by refining the structure and function of LP-40. Two new lipopeptides showed dramatically enhanced secondary structures and binding stability and were exceptionally potent inhibitors of HIV-1, HIV-2, simian immunodeficiency virus (SIV), and simian-human chimeric virus (SHIV), with mean IC50 values at very low picomolar concentrations...
June 13, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29898995/ews-ets-driven-ewing-sarcoma-requires-bet-bromodomain-proteins
#18
Paradesi Naidu Gollavilli, Aishwarya Pawar, Kari Wilder-Romans, Natesan Ramakrishnan, Carl G Engelke, Vijaya L Dommeti, Pranathi M Krishnamurthy, Archana Nallasivam, Ingrid J Apel, Tianlei Xu, Zhaohui Qin, Felix Y Feng, Irfan A Asangani
The EWS/ETS fusion transcription factors drive Ewing sarcoma (EWS) by orchestrating an oncogenic transcription program. Therapeutic targeting of EWS/ETS has been unsuccessful; however, identifying mediators of the EWS/ETS function could offer new therapeutic options. Here we describe the dependency of EWS/ETS-driven transcription upon chromatin reader BET bromdomain proteins and investigate the potential of BET inhibitors in treating EWS. EWS/FLI1 and EWS/ERG were found in a transcriptional complex with BRD4, and knockdown of BRD2/3/4 significantly impaired the oncogenic phenotype of EWS cells...
June 13, 2018: Cancer Research
https://www.readbyqxmd.com/read/29898965/b7-h4-modulates-regulatory-cd4-t-cell-induction-and-function-via-ligation-of-a-semaphorin-3a-plexin-a4-neuropilin-1-complex
#19
Joseph R Podojil, Ming-Yi Chiang, Igal Ifergan, Ronald Copeland, Linda N Liu, Sebastien Maloveste, Solomon Langermann, David Liebenson, Roumen Balabanov, Hongbo Chi, Lieping Chen, Dario A A Vignali, Stephen D Miller
The potent immune regulatory function of an agonistic B7-H4-Ig fusion protein (B7-H4Ig) has been demonstrated in multiple experimental autoimmune models; however, the identity of a functional B7-H4 receptor remained unknown. The biological activity of B7-H4 is associated with decreased inflammatory CD4+ T cell responses as supported by a correlation between B7-H4-expressing tumor-associated macrophages and Foxp3+ T cells within the tumor microenvironment. Recent data indicate that members of the semaphorin (Sema)/plexin/neuropilin (Nrp) family of proteins both positively and negatively modulate immune cell function...
June 13, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29897786/newcastle-disease-virus-is-an-updated-attenuated-vaccine-needed
#20
Ehud Shahar, Ruth Haddas, Dana Goldenberg, Avishai Lublin, Itai Bloch, Noa Bachner Hinenzon, Jacob Pitcovski
Newcastle disease virus (NDV) is a major cause of infectious mortality and morbidity in poultry worldwide. It is an enveloped virus with two outer-membrane proteins-hemagglutinin-neuraminidase (HN) and fusion protein (F)-that induce neutralizing antibodies. All NDV strains belong to one serotype. Yet, NDV vaccines, derived from genotype II, do not fully prevent infection or shedding of viruses from other genotypes. The aim of this study was to test if an updated vaccine is required. For this purpose, NDVs isolated from infected, albeit heavily vaccinated flocks, were genetically and immunologically characterized...
June 13, 2018: Avian Pathology: Journal of the W.V.P.A
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