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https://www.readbyqxmd.com/read/29471565/fibrolamellar-carcinoma-recent-advances-and-unresolved-questions-on-the-molecular-mechanisms
#1
Gadi Lalazar, Sanford M Simon
Fibrolamellar hepatocellular carcinoma (FLC) is a rare form of primary liver cancer that affects adolescents and young adults without underlying liver disease. Surgery remains the mainstay of therapy; however, most patients are either not surgical candidates or suffer from recurrence. There is no approved systemic therapy and the overall survival remains poor. Historically classified as a subtype of hepatocellular carcinoma (HCC), FLC has a unique clinical, histological, and molecular presentation. At the genomic level, FLC contains a single 400kB deletion in chromosome 19, leading to a functional DNAJB1-PRKACA fusion protein...
February 2018: Seminars in Liver Disease
https://www.readbyqxmd.com/read/29471453/modified-minimally-invasive-transforaminal-lumbar-interbody-fusion-technique-can-potentially-improve-safety-of-interbody-graft-placement
#2
Khalid H Kurtom, Wendy S Towers
BACKGROUND: Minimally invasive transforaminal lumbar interbody fusion (MITLIF) is a well-described procedure with excellent reported outcomes. A modification of interbody graft placement can potentially improve the ease and safety of this procedure. OBJECTIVE: To describe a modification of the MITLIF graft placement and retrospectively review our experience including intraoperative and postoperative complications. METHODS: Single surgeon, single institution, retrospective analysis of consecutive patients who underwent a modified MITLIF technique between November 2011 and December 2013...
February 16, 2018: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29470715/issls-prize-in-bioengineering-science-2018-dynamic-imaging-of-degenerative-spondylolisthesis-reveals-mid-range-dynamic-lumbar-instability-not-evident-on-static-clinical-radiographs
#3
Malcolm E Dombrowski, Bryan Rynearson, Clarissa LeVasseur, Zach Adgate, William F Donaldson, Joon Y Lee, Ameet Aiyangar, William J Anderst
PURPOSE: Degenerative spondylolisthesis (DS) in the setting of symptomatic lumbar spinal stenosis is commonly treated with spinal fusion in addition to decompression with laminectomy. However, recent studies have shown similar clinical outcomes after decompression alone, suggesting that a subset of DS patients may not require spinal fusion. Identification of dynamic instability could prove useful for predicting which patients are at higher risk of post-laminectomy destabilization necessitating fusion...
February 22, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29466734/pharmacological-inhibition-of-necroptosis-protects-from-dopaminergic-neuronal-cell-death-in-parkinson-s-disease-models
#4
Angelo Iannielli, Simone Bido, Lucrezia Folladori, Alice Segnali, Cinzia Cancellieri, Alessandra Maresca, Luca Massimino, Alicia Rubio, Giuseppe Morabito, Leonardo Caporali, Francesca Tagliavini, Olimpia Musumeci, Giuliana Gregato, Erwan Bezard, Valerio Carelli, Valeria Tiranti, Vania Broccoli
Dysfunctions in mitochondrial dynamics and metabolism are common pathological processes associated with Parkinson's disease (PD). It was recently shown that an inherited form of PD and dementia is caused by mutations in the OPA1 gene, which encodes for a key player in mitochondrial fusion and structure. iPSC-derived neural cells from these patients exhibited severe mitochondrial fragmentation, respiration impairment, ATP deficits, and heightened oxidative stress. Reconstitution of normal levels of OPA1 in PD-derived neural cells normalized mitochondria morphology and function...
February 20, 2018: Cell Reports
https://www.readbyqxmd.com/read/29465352/immune-response-against-the-coiled-coil-domain-of-sj%C3%A3-gren-s-syndrome-associated-autoantigen-ro52-induces-salivary-gland-dysfunction
#5
Magdalena Sroka, Harini Bagavant, Indranil Biswas, Abigail Ballard, Umesh S Deshmukh
OBJECTIVES: The structural domains of Ro52, termed the RING, B-box, coiled coil (CC) and B30.2/SPRY are targets of anti-Ro52 in multiple autoimmune disorders. In Sjögren's syndrome patients, the presence of anti-Ro52 is associated with higher disease severity, and in mice, they induce salivary gland hypofunction. This study was undertaken to investigate whether immune responses against different domains of Ro52, influences salivary gland disease in mice. METHODS: Female NZM2758 mice were immunised with Ro52 domains expressed as recombinant fusion proteins with maltose binding protein (MBP) [MBP-RING-B-box, MBP-CC, MBP-CC(ΔC19), MBP-B30...
January 31, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29464364/fatty-acids-promote-bovine-skeletal-muscle-satellite-cell-differentiation-by-regulating-elovl3-expression
#6
Jiahui Xu, Dan Liu, Hongyan Yin, Huili Tong, Shufeng Li, Yunqin Yan
Fatty acids (FAs) play essential roles in regulating differentiation and proliferation by affecting gene expression in various cell types. However, their potential functions in bovine cells remain unclear. Herein, we examine the differentiation and proliferation of bovine skeletal muscle-derived satellite cells (MDSCs) after incubation with three types of representative FAs (palmitic acid, oleic acid and docosahexaenoic acid) by western blotting, immunofluorescence assays, flow cytometry analysis and EdU incorporation assays...
February 20, 2018: Cell and Tissue Research
https://www.readbyqxmd.com/read/29462968/feature-level-fusion-of-surface-electromyography-for-activity-monitoring
#7
Xugang Xi, Minyan Tang, Zhizeng Luo
Surface electromyography (sEMG) signals are commonly used in activity monitoring and rehabilitation applications as they reflect effectively the motor intentions of users. However, real-time sEMG signals are non-stationary and vary to a large extent within the time frame of signals. Although previous studies have focused on the issues, their results have not been satisfactory. Therefore, we present a new method of conducting feature-level fusion to obtain a new feature space for sEMG signals. Eight activities of daily life (ADLs), including falls, were performed to obtain raw data from EMG signals from the lower limb...
February 17, 2018: Sensors
https://www.readbyqxmd.com/read/29462728/treatment-of-lumbar-discitis-using-silicon-nitride-spinal-spacers-a-case-series-and-literature-review
#8
William M Rambo
INTRODUCTION: Septic infection of a lumbar intervertebral disc is a serious disorder which is often difficult to diagnose and appropriately treat because of the rarity of the disease, the varied presentation of symptoms, and the frequency of low-back pain within the overall population. Its etiology can be pyogenic, granulomatous, fungal, or parasitic; its incidence is rising due to increased patient susceptibility and improved diagnostic tools. Conservative treatments involve antibiotics, physical therapy, and/or immobilization...
February 10, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29462060/iliac-crest-bone-graft-for-minimally-invasive-transforaminal-lumbar-interbody-fusion-a-prospective-analysis-of-inpatient-pain-narcotics-consumption-and-costs
#9
Brittany E Haws, Benjamin Khechen, Ankur S Narain, Fady Y Hijji, Kaitlyn L Cardinal, Jordan A Guntin, Kern Singh
STUDY DESIGN: Retrospective Analysis OBJECTIVE.: The aim of this study was to determine whether an association between increased acute pain, postoperative time, and direct hospital costs exists between the use of iliac crest bone grafting (ICBG) and bone morphogenic protein (BMP)-2 following a primary, single-level minimally invasive transforaminal lumbar interbody fusion (MIS TLIF). SUMMARY OF BACKGROUND DATA: ICBG has been associated with enhanced fusion rates...
February 16, 2018: Spine
https://www.readbyqxmd.com/read/29462040/in-patients-with-one-level-lumbar-degenerative-spondylolisthesis-a-posterior-approach-with-transforaminal-lateral-interbody-fusion-improved-radiographic-but-not-clinical-outcomes
#10
R Douglas Orr
No abstract text is available yet for this article.
February 21, 2018: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/29462037/the-free-hand-technique-for-s2-alar-iliac-screw-placement-a-safe-and-effective-method-for-sacropelvic-fixation-in-adult-spinal-deformity
#11
Jamal N Shillingford, Joseph L Laratta, Lee A Tan, Nana O Sarpong, James D Lin, Charla R Fischer, Ronald A Lehman, Yongjung J Kim, Lawrence G Lenke
BACKGROUND: Spinopelvic fixation is an integral part of achieving solid fusion across the lumbosacral junction, especially in deformity procedures requiring substantial correction or long-segment constructs. Traditional S2-alar-iliac (S2AI) screw-placement techniques utilize fluoroscopy, increasing operative time and radiation exposure to the patient and surgeon. We describe a novel free-hand technique for S2AI screw placement in patients with adult spinal deformity. METHODS: We reviewed the records of 45 consecutive patients who underwent spinopelvic fixation performed with use of S2AI screws by the senior surgeon and various fellows or residents over a 12-month period (2015 to 2016)...
February 21, 2018: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/29461635/clinical-and-mutational-spectrum-of-highly-differentiated-paired-box-3-forkhead-box-protein-o1-fusion-negative-rhabdomyosarcoma-a-report-from-the-children-s-oncology-group
#12
Lisa A Teot, Michaela Schneider, Aaron R Thorner, Jing Tian, Yueh-Yun Chi, Matthew Ducar, Ling Lin, Marcin Wlodarski, Holcombe E Grier, Christopher D M Fletcher, Paul van Hummelen, Stephen X Skapek, Douglas S Hawkins, Amy J Wagers, Carlos Rodriguez-Galindo, Simone Hettmer
BACKGROUND: Pediatric paired box 3:forkhead box protein O1 fusion-negative (PF-) rhabdomyosarcoma (RMS) represents a diverse spectrum of tumors with marked differences in histology, myogenic differentiation, and clinical behavior. METHODS: This study sought to evaluate the clinical and mutational spectrum of 24 pediatric PF- human RMS tumors with high levels of myogenic differentiation. Tumors were sequenced with OncoPanel v.2, a panel consisting of the coding regions of 504 genes previously linked to human cancer...
February 20, 2018: Cancer
https://www.readbyqxmd.com/read/29459657/very-long-and-long-chain-3-hydroxy-acyl-coa-dehydrogenase-deficiency-correlates-with-deregulation-of-the-mitochondrial-fusion-fission-machinery
#13
Judith Hagenbuchner, Sabine Scholl-Buergi, Daniela Karall, Michael J Ausserlechner
Children diagnosed with Long-Chain-3-Hydroxy-Acyl-CoA-Dehydrogenase-Deficiency (LCHADD) or Very-Long-Chain-3-Hydroxy-Acyl-CoA-Dehydrogenase-Deficiency (VLCADD) frequently present with hypertrophic cardiomyopathy or muscle weakness which is caused by the accumulation of fatty acid metabolites due to inactivating mutations in the mitochondrial trifunctional protein. By analyzing mitochondrial morphology we uncovered that mutations within the HADHA or the ACADVL gene not only affect fatty acid oxidation, but also cause significant changes in the DNM1L/MFN2 ratio leading to the significant accumulation of truncated and punctate mitochondria in contrast to network-like mitochondrial morphology in controls...
February 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29459424/the-role-of-adherens-junction-proteins-in-the-regulation-of-insulin-secretion
#14
Waruni C Dissanayake, Brie Sorrenson, Peter R Shepherd
In healthy individuals any rise in blood glucose levels is rapidly countered by the release of insulin from the β-cells of the pancreas which in turn promotes the uptake and storage of the glucose in peripheral tissues. The β-cells possess exquisite mechansims regulating the secretion of insulin to ensure that the correct amount of insulin is released. These mechanisms involve tight control of the movement of insulin containing secretory vesicles within the β-cells, initially preventing most vesicles being able to move to the plasma membrane...
February 19, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29458996/quantitative-comparisons-of-three-automated-methods-for-estimating-intracranial-volume-a-study-of-270-longitudinal-magnetic-resonance-images
#15
Xiaoyan Shang, Michelle C Carlson, Xiaoying Tang
Total intracranial volume (TIV) is often used as a measure of brain size to correct for individual variability in magnetic resonance imaging (MRI) based morphometric studies. An adjustment of TIV can greatly increase the statistical power of brain morphometry methods. As such, an accurate and precise TIV estimation is of great importance in MRI studies. In this paper, we compared three automated TIV estimation methods (multi-atlas likelihood fusion (MALF), Statistical Parametric Mapping 8 (SPM8) and FreeSurfer (FS)) using longitudinal T1-weighted MR images in a cohort of 70 older participants at elevated sociodemographic risk for Alzheimer's disease...
February 11, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29458539/immunogenicity-in-chickens-with-orally-administered-recombinant-chicken-borne-lactobacillus-saerimneri-expressing-fima-and-ompc-antigen-of-o78-avian-pathogenic-escherichia-coli
#16
Sun-Ting Ma, Guo-Jie Ding, Xue-Wei Huang, Zi-Wei Wang, Li Wang, Mei-Ling Yu, Wen Shi, Yan-Ping Jiang, Li-Jie Tang, Yi-Gang Xu, Yi-Jing Li
PURPOSE: Avian colibacillosis is responsible for economic losses to poultry producers worldwide. To combat this, we aimed to develop an effective oral vaccine for chicken against O78 avian pathogenic Escherichia coli (APEC) infection through a Lactobacillus delivery system. METHODOLOGY: Eight Lactobacillus strains isolated from the intestines of broiler chickens were evaluated based on their in vitro adherence ability to assess their potential as a delivery vector...
January 19, 2018: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29458048/4-phenylbutyric-acid-protects-against-lipopolysaccharide-induced-bone-loss-by-modulating-autophagy-in-osteoclasts
#17
Hyun-Jung Park, Ho-Jung Son, Ok-Joo Sul, Jae-Hee Suh, Hye-Seon Choi
4-Phenylbutyric acid (4-PBA) has been used clinically to treat urea cycle disorders and is known to be an inhibitor of endoplasmic reticulum (ER) stress. We hypothesized that 4-PBA attenuates inflammatory bone loss by inducing autophagy, a process that is frequently accompanied by ER stress. Micro computerized tomography analysis showed that 4-PBA attenuated LPS-induced bone loss in mice. The increased area of TRAP-positive osteoclasts (OCs) and serum level of collagen type I fragments in lipopolysaccharide (LPS)-treated mice were also decreased when 4-PBA was administered, suggesting a protective role of 4-PBA in OCs...
February 16, 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29456920/evidence-based-analysis-of-adjacent-segment-degeneration-and-disease-after-lif-a-narrative-review
#18
Nikunj N Trivedi, Sean M Wilson, Luis A Puchi, Darren R Lebl
Study Design: Narrative review. Objectives: The etiology of adjacent segment degeneration (ASDeg) and adjacent segment disease (ASDz) after lumbar interbody fusion (LIF) remains controversial. The aim of this narrative review was to provide an evidence-based analysis of the peer-reviewed literature on clinical studies of ASDeg and ASDz after LIF. Methods: A review was performed utilizing Medline, Embase, and Cochrane databases. Two reviewers independently extracted relevant data from each included study...
February 2018: Global Spine Journal
https://www.readbyqxmd.com/read/29456918/cervical-disc-arthroplasty-a-comprehensive-review-of-single-level-multilevel-and-hybrid-procedures
#19
REVIEW
Joseph L Laratta, Jamal N Shillingford, Comron Saifi, K Daniel Riew
Study Design: Systematic review. Objectives: Degenerative disc disease and spondylosis resulting in radiculopathy and retrodiscal myelopathy are among the most frequently encountered cervical spinal disorders. Traditionally, anterior cervical discectomy and fusion (ACDF) has successfully achieved neural decompression and restored intradiscal height in these conditions. Unfortunately, nonunion and iatrogenic adjacent segment pathology associated with fusion procedures in the cervical spine has led to an interest in motion-preserving procedures...
February 2018: Global Spine Journal
https://www.readbyqxmd.com/read/29456914/is-cervical-bracing-necessary-after-one-and-two-level-instrumented-anterior-cervical-discectomy-and-fusion-a-prospective-randomized-study
#20
Samuel C Overley, Robert K Merrill, Evan O Baird, Joshua J Meaike, Samuel K Cho, Andrew C Hecht, Sheeraz A Qureshi
Study Design: Prospective randomized control trial. Objective: To investigate the role of cervical collars in postoperative care following 1- and 2-level instrumented anterior cervical discectomy and fusion (ACDF). Methods: The Cervical Spine Research Society Resident Fellow Grant funded this project. Fifty consecutive patients undergoing 1- or 2-level ACDF surgery were randomized into groups receiving either no brace or a cervical brace for 6 weeks postoperatively...
February 2018: Global Spine Journal
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